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Evidence That Ultraviolet B Radiation Generates Systemic Responses Via Microvesicle Particle, Niharika Annapureddy

Browse all Theses and Dissertations

Ultraviolet B (UVB) radiation, ranging from 280–315 nm, has been identified as carcinogenic since 1928 and is known to cause skin cancer. Additionally, UVB exposure triggers inflammatory responses, systemic effects, and organ damage. Recent research has discovered that these adverse outcomes are facilitated by the release of microvesicle particles (MVP) via the inflammatory lipid mediator, Platelet-activating Factor (PAF). We have previously demonstrated that sunburn causes skin keratinocytes to release high levels of MVP by activating the PAF receptor (PAFR). These studies were designed to test if these microvesicles enter the bloodstream and travel to various organs, especially the gut, increasing …

Systemic Effects Of Varying Degrees Of Thermal Burn Injuries In Young Mice: Role Of Microvesicle Particles And Platelet-Activating Factor, Prince Wilfred

Browse all Theses and Dissertations

Thermal burn injuries (TBI) result in local and systemic effects, particularly when a large body surface area is exposed to TBI. This study investigates the systemic effects of varying degrees of TBI in the murine model, focusing on the role of microvesicle particles (MVP) and Platelet-activating Factor (PAF) in mediating bacterial translocation and systemic inflammation. Utilizing the murine model, we analyzed MVP levels in the skin and blood, bacterial translocation in the gut, and the expression of pro-inflammatory mediators in the major organs at the 2-hour post-burn time point. Our studies revealed that after the two hours’ time point TBI …

Ready, Set, Resistance: A Dual Continuum Approach To Organizational Change Acceptance, Alexandria Bohn

Browse all Theses and Dissertations

With organizations operating in increasingly dynamic and competitive landscapes, organizations need to be able to get their employees to adapt to system-wide changes that are needed. However, research has suggested a 70% failure rate for organizational change initiatives (Hughes, 2011). Prior research has produced mixed research results when examining resistance and readiness to organizational change on either a single dimension (e.g., Kaplan, 1972) or two dimensions (e.g., Repovs, Drnovsek, & Kase, 2019). I extended prior research by examining resistance versus readiness as residing on a single continuum and whether effects on outcomes were moderated by change orientations. Research has suggested …

Mobile Weather Satellite Receiver, Luke Datsko, Sam Watts, Jason Do, Adam Bechtler

Williams Honors College, Honors Research Projects

The "Mobile Weather Satellite Receiver" project aims to create a portable, user-friendly device that receives and displays weather information from geostationary satellites, addressing the limitations of traditional weather sources like the Internet and weather radio, particularly in remote areas. This device will collect and demodulate satellite data, including imagery and Emergency Managers Weather Information Network (EMWIN) forecasts, to provide users with detailed local forecasts and real-time alerts.

Designed with a user-centric approach, the system includes a satellite dish, Software Defined Radio (SDR), a Raspberry Pi, and a custom software interface for ease of use. Its portability and ability to function …

The Vital Role Of Interpreters In The Deaf Community: Navigating Accessibility Amidst Declining Deia Initiatives, Andrew Kovacs

Williams Honors College, Honors Research Projects

The catalyst for this research project stems from the rollback of Diversity, Equity, Inclusion, and Accessibility (DEIA) initiatives under the current presidential administration. Executive Orders from the presidential office have caused budget cuts and pauses in federal programs that affect all types of communities across the United States. For the Deaf community, funding for federal and state programs aimed at training ASL interpreters, helping Deaf individuals find jobs, and other communicative tools used by native signers has been paused. Despite the urgency of this issue, few studies have looked at the intersection of Deaf accessibility and the decline of DEIA …

Symposium: Defending Tomorrow’S Democracy—The Future Of Elections In The Era Of Advanced Technology - Introduction - Everything Old Is New Again—Advancing Technology And Enduring Problems In American Democracy, Atiba R. Ellis

Case Western Reserve Law Review

No abstract provided.

Algorithmic Lawmaking, Moral Judging, And Free Will, Jacob Eisler

Case Western Reserve Law Review

No abstract provided.

Novel Ai/Ml-Based Frameworks For Protein Conformation Selection In Drug Discovery Applications, Shivangi Gupta

Dissertations

Drug development is a lengthy, expensive process with a high failure rate. The urgency brought on by the COVID-19 pandemic has accelerated the integration of artificial intelligence (AI) and machine learning (ML) to enhance drug discovery by increasing target specificity, reducing toxicity, and optimizing formulation strategies. Building on this momentum, this dissertation introduces novel AI/ML-driven frameworks for protein conformation selection and classification, addressing critical challenges in modern drug discovery. However, designing such a novel AI/ML data-driven framework is a difficult task because most real-world biomedical datasets suffer from class imbalance issues, which can significantly skew AI/ML model training, resulting in …

In Vitro Characterization And Evolution Of Sylvatic And Endemic Dengue-4 Viruses, Andrew Peric

Yale Graduate School of Arts and Sciences Dissertations

Dengue virus is the world’s preeminent arthropod-borne virus that infects hundreds of millions of people each year, and circulates in four distinct serotypes named 1, 2, 3, and 4. Dengue virus cycles between mosquito and human hosts in a transmission cycle called the endemic cycle, which is responsible for the majority of recorded dengue infections worldwide. However, dengue also exists in a second transmission cycle called the sylvatic cycle, which mirrors the endemic cycle with wildlife, including non-human primates, replacing humans in this transmission cycle. Phylogenetic analyses support the hypothesis that spillover events from the sylvatic cycle into human populations …

Ready Or Not, The Deadline Is Coming! Getting Onboard With Accessible Course Content, Karen Edwards, Lena Pinkston

Faculty Publications

People with disabilities often have less engagement with and access to online resources (Lissitsa & Madar, 2018). Accordingly, the Department of Justice’s (DOJ) Final Rule (89 FR 31320, 2024) for Title II of the Americans with Disabilities Act of 1990 (ADA) requires many public educational institutions and others to comply with the Web Content Accessibility (WCAG) Guidelines Version 2.1 AA by April 24, 2026. Compliance officers and technology specialists across the country have been working to make sure institutional websites and apps meet the Guidelines. Despite spirited debate during the rulemaking process, the updated rule also requires instructional content within …

Globe Resources For 2025 Summer Reading Programming, Haley F. Wicklein, Globe U.S. Coordination Office

Teacher Resources

No abstract provided.

Globe And Natural Inquirer Crosswalk Upper Elementary: Exploring Seasons And Silvery Minnows With The Natural Inquirer And Elementary Globe, Caleigh Fleming, Ashley Kacmarski, Globe U.S. Coordination Office

Teacher Resources

No abstract provided.

Lecture Responsive Democracy And The Administrative State, Edward L. Rubin

Case Western Reserve Law Review

No abstract provided.

Soil Tent: Implementation Guide, Haley F. Wicklein, Alicia Carlson

Earth Around Us

No abstract provided.

Mitigating And Preparing For Disasters At The Organizational Level: A Global Systematic Literature Review, Abdul-Akeem Sadiq, Ratna B. Dougherty, Rebecca Entress, Bikash Adhikari, Katherine Wilson Mccoy, Emilie Rott, Grace L. Chikoto-Schultz, Shannon Maharajh

Faculty Scholarship and Creative Works

Organizations play significant roles in society by providing goods and services and contributing to the economies of communities, globally. Amid the predicted increase in the frequency and impact of disasters, which will invariably lead to higher disaster costs, there is an urgent need to ameliorate disaster impact on society and organizations. Disaster mitigation and preparedness are strategies for stemming disaster impact and losses within organizations. Cognizant of the importance of disaster mitigation and preparedness, researchers have conducted a myriad of studies on both concepts at the organizational level. To advance knowledge on this topic, this study conducted a comprehensive systematic …

Development And Application Of Gpu Based Monte Carlo Simulation Techniques In Radiation Medicine, Satzhan Sitmukhambetov

Physics Dissertations - Archive

Cancer remains a significant public health challenge, with treatments like radiation therapy forming a cornerstone of modern care. To address this challenge, advanced computer simulations can improve radiotherapy in two primary ways. From one hand, mechanistic simulations help elucidate the fundamental radiobiological working principles, which could contribute to the clinical advancements from a bottom-up framework. On the other hand, modality simulations could help design better clinical systems with better detection and therapeutic capabilities. This research enhances these critical simulation tools by introducing two significant developments.

First, this work introduces a metaphase DNA model into a microscopic Monte Carlo simulation framework …

West From West Point: The U.S. Military Academy And The Romantic Frontier, Ryan Shaw

Yale Graduate School of Arts and Sciences Dissertations

This dissertation examines the influence of Romanticism on the culture and curriculum of the United States Military Academy in the early nineteenth century, and demonstrates how it shaped the behavior of U.S. Army officers on the far western frontier. While historians have long associated Romanticism with the frontier experience, it has traditionally been framed as an output, rather than an input. This study identifies West Point as an unexpected but significant source of Romantic ideals.

The history of the Academy is presented uniquely here as a contest between three competing visions: A republican ideal of a modest military …

Breaking Ground On Self-Efficacy: A Qualitative Exploration Of Intimate Partner Violence Survivors’ Experiences With Therapeutic Horticulture, Rachel Marie Reeves

Theses and Dissertations--Sociology

This dissertation explores how participation in a Therapeutic Horticulture program may support the self-efficacy of survivors of Intimate Partner Violence. Through a thematic analysis of interviews with 45 women living at a domestic violence shelter in Lexington, Kentucky, this study investigates whether and how gardening activities contributed to participants’ belief in their abilities to shape outcomes in their lives.

Findings are organized around Bandura’s four sources of self-efficacy: enactive mastery experiences, vicarious experience, verbal persuasion, and physiological/affective states. These insights contribute to feminist criminology and trauma-informed care literature by illuminating the transformative potential of nature-assisted healing programs.

Dna Methylation Variation In Eastern Diamondback Rattlesnakes (Crotalus Adamanteus) On A Georgia Barrier Island, Megan Hoog

College of Graduate Studies: Theses & Dissertations

The Eastern Diamondback Rattlesnake (Crotalus adamanteus, EDB) is the largest rattlesnake in the world and is thought to be declining in many portions of its range. Genetic venom studies in the Southeast United States have shown evidence of fine-scale differences within two main geographic groups on Jekyll Island. My objective is to expand on this finding to determine if epigenetic mechanisms, specifically DNA methylation, varies among different populations of EDB in similar environments, age classes, and sexes. I collected EDB blood samples through a partnership with the Jekyll Island Authority and screened 44 individuals for epigenetic variation from …

The Diseased Extracellular Matrix In Chronic Obstructive Pulmonary Disease Modeling, Leigh-Ann M. Antczak

Theses and Dissertations

Chronic obstructive pulmonary disease (COPD) is currently the fourth leading cause of death in the world, with an increasing prevalence as the world’s population ages. In the distal regions of the lungs, COPD is characterized by progressive emphysema due to an imbalance of proteases that continuously degrade essential extracellular matrix (ECM) proteins within the alveolar walls, causing fatal tissue impairment. This dissertation examines the unique properties of this diseased lung ECM in two parts: (1) As a key constituent in inflammatory signaling that leads to increased inflammation and progression of COPD, and (2) as a tool in three-dimensional (3D) in …

Bs Clinical Laboratory Science, Biological Sciences

Program Revisions/Additions

No abstract provided.

Wiring Attachment, Alexander K. Bacon

Theses and Dissertations

This thesis began with a question: can diagrams create understanding, or only reflect it? Through paintings that layer automotive wiring schematics with family photographs, I explore how the human attachment system resists easy mapping. Using digital tools like Photoshop and scanning, alongside analog methods such as papier-collé and photo transfer, I examine how systems built for clarity—like wiring diagrams—contrast with the layered, often messy realities of human relationships. Drawing from attachment theory’s empirical foundation, rather than the metaphorical leanings of psychoanalysis, my work investigates how emotional bonds form, falter, and repair over time. Material loss and layering are not flaws, …

The Dance Of Human Affairs: Public Administration Leaders’ Perceptions Of Candor’S Impact On A Sense Of Belonging, Aaron Dimmock

Theses and Dissertations

This dissertation examines public administration leaders’ perceptions within the executive branch of the state government studied to determine if the components of radical candor, care personally and challenge directly, are associated with the sense of belonging in a public administration setting. Questions from surveys conducted by the state government studied were used to create the variables analyzed in this study. To the researcher’s knowledge, this is the first study to apply components from the Radical Candor® Framework to determine a relationship with sense of belonging in a public administration setting.

The significance of these components was tested through a quantitative, …

Identification Of Mechanisms Associated With Electronic Nicotine Delivery System Use For Weight Control In Young Adults, Gabrielle Maldonado

Theses and Dissertations

Electronic nicotine delivery system (ENDS) use continues to rise among young adults in the United States, raising public health concerns as the harmful effects of ENDS continue to rise while tailored cessation programs lag. Weight control motives may drive ENDS initiation and frequent use, particularly among sexual and gender minority (SGM) populations, who report higher ENDS use, body dissatisfaction, and disordered eating behaviors than those who identify as heterosexual and cisgender. Understanding these behaviors, their mechanisms, and at-risk populations is critical for improving public health. Seven hundred and eight young adults (ages 18–30; M = 26, SD = 3.3) reporting …

Ecological Interactions Of Large Mammals In Luangwa, Zambia, Jahzara Osborne, Amelia Villaseñor

2025 Research Poster Competition

"The connection between mammalian behavior in national parks and human-driven environmental change is tenuous. National parks are often considered the last vestiges of natural space, yet they are created and maintained by humans. South Luangwa National Park (SLNP) within the southern East African Rift is a microcosm of this global conundrum and is also a region where stable isotope data is sparce. Understanding the mammalian diets of mammals in the SLNP via carbon and oxygen stable isotopes in teeth will provide a means of understanding variation in one aspect of mammal behavior that may be affected by changing animal-human relationships. …

Unbridled Healing: Identifying The Barriers Of Equine-Assisted Therapy, Sally A. Hamm, Amanda Terrell

2025 Research Poster Competition

Despite the documented benefits of equine-assisted therapy (EAT) for mental health conditions, this complementary approach remains underutilized. This qualitative study investigated barriers preventing wider EAT implementation by examining challenges faced by clients, facilities, and volunteers. Data collected through open-ended surveys from 33 participants and the researcher's autoethnographic observations revealed eight common barriers: Accessibility (48 mentions), Money (43), Time (30), Awareness (23), Physical Factors (13), Relationships (13), Risk (13), and Weather (7). Clients identified financial constraints as their primary barrier, particularly insurance limitations. Facilitators struggled most with accessibility challenges, including lack of resources, trained staff, suitable horses, and appropriate facilities. Volunteers …

Effect Of Vibration Isolation During Transportation On Beef Sirloin Subprimal And Steak Quality, Kylie Nevada Krueger

Electronic Theses and Dissertations

The objective of this study was to determine the influence of vibration during transportation on beef sirloin water holding capacity, color, and tenderness. USDA Choice center-cut sirloin top butts (n = 45 cases) were collected at a commercial processing facility and randomly allocated to one of three treatments 1) regular pallet driven 241 km (Reg241), 2) regular pallet driven 644 km (Reg644), and 3) vibration isolation pallet driven 644 km (Iso644). All subprimals were transported at -2.2 °C (d0) and stored for 10 days to mimic industry practices for product aging. Following storage (d11), one subprimal per case was evaluated …

Adam As Imago Dei Statue In The Hebrew Bible, Andrei Orlov

Theology Faculty Research and Publications

In recent decades, there has been a significant shift in scholarly perspectives on ancient Near Eastern cultic images. This shift moves away from the traditional view that regarded cultic statues as merely idolatrous representations — an attitude often reflected in certain biblical narratives—toward a more nuanced understanding of these images as paradoxical channels for divine presence. Recent research on polemics against idolatry in the Hebrew Bible and other Jewish texts reveals efforts to recontextualize traditions of cultic statues within the lives of biblical patriarchs and prophets, portraying them as bearers of the sacred.

Polarimetric Capture And Differentiable Rendering, Katherine Anne Salesin

Dartmouth College Ph.D Dissertations

Many scientific fields rely on the capture and modeling of light to extract underlying information about the world. Often, more information can be extracted by capturing more about the nature of the light, such as its spectral shape or polarization state. While polarization is a relatively unexplored topic in computer graphics, when used in tandem with other recent advancements in the field it has enormous potential to improve both forward and inverse models in other scientific disciplines. We demonstrate this potential in two distinct settings in this thesis.

First, we apply the capture of polarized light to an inverse problem …

The Fearless Decision And The Future Of Race-Conscious Charities, Chenglin Liu

Faculty Articles

Historically, courts tended to differentiate between invidious discrimination against racial minorities and benign discrimination against whites in the context of affirmative action movements. With the social movements galvanized by the conservatives and the change of composition of the Supreme Courts and lower courts, the feasibility of race-conscious measures aimed at helping minorities is substantially reduced. The conservatives' win in Fearless, coupled with the Trump Administration's attacks on DEI, have produced a self-censoring effect on charitable organizations. Because of these threats, race-conscious charities will have to modify their practices to become more "inclusive" or face legal challenges from conservatives.