Digital Commons Network^™

Lis1 Depletion In Adult Mouse Projection Neurons Causes Neurodegeneration And Severe Neurological Phenotypes, Anne Ventrone

Theses and Dissertations

Proper LIS1 function is crucial for human brain development, as mutations in LIS1 lead to lissencephaly, a severe neurodevelopmental disorder caused by defective proliferation, differentiation and migration of neural precursors. Our understanding of LIS1's functions after brain development is limited. LIS1 regulates cytoplasmic dynein 1 (dynein), an essential microtubule motor protein in cell division and migration, but also a cellular transport motor. We previously showed that tamoxifen (TX)-induced global knockout of LIS1 using a Cre/Lox system (Act-Lis1iKO) in young adult mice results in severe neurological defects and rapid lethality. This strongly supports LIS1's critical post- developmental role, but the underlying …

The Effectivity Of The Combination Of Tricalcium Silicate Cement And Galam Leaf Extract (Melaleuca Cajuputi Subsp. Barlow) As Direct Pulp Capping Materials Reviewed From Vegf, Fgf-2, And Tgf-Β: A Systematic Review, Sherli Diana, Irene E. Rieuwpassa, Juni J. Nugroho, Rasmidar Samad, Risfah Yulianty, Nurhayaty Natsir

Journal of Dentomaxillofacial Science

No abstract provided.

Restoring Tranquility : Tackling Traffic Noise For Enhanced Comfort In Indonesia Kaya Park, Semarang City, Indonesia, David Suwarno Kusweanto, Natania Nysa Pertiwi N. S., Eldisya Martha Jebatu

NAKHARA (Journal of Environmental Design and Planning)

The comfort of a landscape can be seen from the microclimate and traffic noise in the landscape. Traffic noise, including tire and engine noise, is a common disturbance, particularly in cities, and can lead to diseases. Indonesia Kaya Park, located in Mugassari, Semarang City, is an urban park and public space managed by the Djarum Foundation. Despite numerous studies evaluating its accessibility and biophilic elements, the condition of traffic noise nor potential interventions have been considered. The research question aims to understand the traffic noise condition of Indonesia Kaya Park and identify necessary interventions. The study used a mixed methodology, …

A Framework For Ordinary Urban Heritage Mapmaking : The Case Of Trok In Rattanakosin, Bangkok’S Historic Center, Prin Jhearmaneechotechai

NAKHARA (Journal of Environmental Design and Planning)

This research offers an alternative mapmaking framework for Ordinary Urban Heritage (OUH), specifically applied to the Trok (local alleys) of Bangkok's Rattanakosin district. Departing from conventional approaches that might map Trok solely as pedestrian urban patterns, this framework uniquely explores Trok as dynamic urban spaces that enable the manifestation of diverse everyday heritages, including temporary commercial activities, people’s way of living, and sacred spaces, thereby revealing a richer understanding of OUH. The framework's development is grounded in the analysis of existing mapping practices, historical maps, and non-participatory surveys, incorporating five key OUH selection criteria sensitive to these dynamic manifestations: (1) …

Tradition And Modernity : The Adaptation Of Outdoor Spaces In Traditional Balinese Dwelling, Kristanti Paramita, Aswin Indraprastha, Agus Hariyadi, Yandi Andri Yatmo, Paramita Atmodiwirjo, Rini Suryantini

NAKHARA (Journal of Environmental Design and Planning)

This study investigates the dialectical relation between tradition and current everyday domestic practices in traditional Balinese dwellings that manifest through the spatial adaptation of their outdoor spaces. Traditional Balinese dwellings consist of a compound collection of partly open pavilions surrounded by open spaces, following the symbolic classification of Balinese cosmology, Sanga Mandala. Dwelling adaptation becomes necessary to enable the support of the changing household needs throughout time, aiming to capture a process that emerges in the current traditional dwellings bounded by a particular cultural order. This study focuses on the spatial adaptation strategies of the outdoor spaces as a …

Dwelling With The Fault : Cultural Landscape And Spatial Formation In Kampung Batu Lonceng, Indonesia, Widjaja Martokusumo, Rr. Diah Asih Purwaningrum, Medria Shekar Rani, M. Zaini Dahlan, Budi Faisal, Izazaya Binta, Irwan Meilano, Hirohide Kobayashi

NAKHARA (Journal of Environmental Design and Planning)

Since UNESCO formalized the concept of cultural landscapes in 1992, heritage discourse has shifted from monument-centric approaches toward values-based perspectives that foreground the dynamic interplay among people, place, and ecology. Within this framework, cultural landscapes offer a critical lens for understanding rural settlements not only as spatial configurations but also as embodiments of intangible knowledge and ecological adaptation.  This study investigates Kampung Batu Lonceng, a vernacular settlement situated along the active Lembang Fault in West Java, Indonesia. With historical traces dating back to the Neolithic period, the kampung exemplifies how spatial formation is shaped simultaneously by geomorphological vulnerabilities and long-standing …

Quantifying The Restorative Effects Of Green–Water–Hardscape Ratios : Evidence From A Simulated Landscape Experiment In Chiang Mai, Hay Thar Htar Ei

NAKHARA (Journal of Environmental Design and Planning)

Modern life presents significant stressors that negatively impact mental well-being. While the importance of mental health is increasingly recognized, effective stress management strategies are still crucial. This study explores the potential of landscape perception as a natural intervention to enhance proximal restorative outcomes. By investigating the physiological and psychological responses of individuals to diverse landscape stimuli, we aim to understand how specific combinations of landscape elements (e.g., green spaces, water features) can promote psychological restoration. The study design intended to collect psychological and physiological (heart rate and blood pressure) responses, measured before and after stress-inducing tests and landscape exposure. Scores …

Interchangeable Sensorial Encounters With Nature In Older Adults’ Domestic Space In Indonesia, Paramita Atmodiwirjo, Ruth Kartika Purnasasmita, Paramita Atmodiwirjo, Yandi Andri Yatmo, Demet Dincer

NAKHARA (Journal of Environmental Design and Planning)

This study investigates how older individuals encounter nature through sensorial contact in their domestic settings. It argues that nature should be integrated into the older adults’ domestic spaces to foster connections with nature that promote active living and improve their well-being. Such interactions with nature are captured by understanding the relationships between the degrees of connection with nature: viewing nature, being in nature, and doing in nature. This study was conducted through field observations and interviews with 24 older adults with varying physical capacities and levels of independence across 15 households in Jakarta and West Java. It further maps the …

Renewing Cells, Enduring Genes, And Metabolic Decline In Murine Liver Aging, John T. Gonzalez

Yale Graduate School of Arts and Sciences Dissertations

Aging is associated with physiological and molecular decline and a concurrent increase in dysfunction, chronic disease, and mortality. Despite the fact that aging is the greatest risk factor for many chronic diseases, fundamental aging research has historically lagged behind disease-specific research. This deterioration and it's repercussions has different manifestations in different organs. This dissertation focuses on dynamics of mouse aging with a focus on the liver. The liver's diverse functions are integral to many homeostatic processes, including maintaining metabolic balance, detoxifying harmful substances, supporting immune defense, and regulating blood and endocrine systems. Its impairment can lead to significant health issues. …

A.R.C.Hitecture For Mission: Prototyping Pathways To Renew The Heart Of The Church, David Sunde

Doctor of Ministry

Despite churches’ commitment to making disciples, many earnest Christians—active in church teaching, volunteering, and community life—feel ill-equipped to disciple others. While biblical instruction and resources abound, spiritual formation weighted toward cognitive learning relies on willpower and falls short in shaping identity and desires. The focus on personal salvation often reduces faith to sin management, leaving many underwhelmed and uncertain about how to live meaningfully as citizens of the kingdom. Without qualitative, relational, and reproductive disciple-making, faith lacks transformative power. A.R.C.hitecture for Mission: Prototyping Pathways to Renew the Heart of the Church is a pracademic manuscript that explores disciple-shaping movements from …

Canine-Assisted Spiritual Care Handbook: Integrating Facility Dogs Into Professional Chaplaincy Practice, Ann M. Snowberger

Doctor of Ministry

This project's researcher finds that Spiritual Care Facility Dog Teams (dog handlers and their dogs) lack resources and practical guides to advance Canine-Assisted Spiritual Care (CA-SC) in healthcare and facility settings. The Canine-Assisted Spiritual Care Handbook offers a comprehensive guide for establishing and sustaining CA-SC programs. It promotes standardized terminology, ethical practices, and interdisciplinary collaboration. By featuring practical tools, case studies, and training plans, the handbook supports the professional development of chaplains. Its holistic framework enhances spiritual, emotional, and physical wellness, while emphasizing the well-being of both handlers and their working dogs. The handbook’s focus on program sustainability and real-world …

Forming The Blessed Alliance: Spiritual Formation For Mutual Leadership In The Church, Erin Richer

Doctor of Ministry

This project is an on-ramp to a spiritual formation pipeline to address the unique formational needs of men and women for effective, cross-gender mutuality in church leadership. The most critical need which female stakeholders identified for leadership in these church spaces is male allies. Therefore, this project provides a practical and concrete formational on-ramp for male leaders to develop as allies for cross-gender mutuality in ministry leadership. This workshop—Forming the Blessed Alliance—will use evangelical language to frame allyship. The workshop launches by laying the biblical groundwork and by teaching 3-Way Listening with a focus on self and spiritual reflection. The …

Neurovascular Coupling Impairments In Acute Traumatic Brain Injury: An Eeg-Nirs Analysis, Zachary Armstrong

Bioengineering Theses - Archive

Traumatic brain injury (TBI) is a major cause of neurological impairment, often leading to variable recovery and uncertain prognosis in the neurocritical care setting. There is a pressing clinical need for robust, physiologically grounded biomarkers to inform prognosis and therapeutic decision-making in acute TBI. This thesis investigates neurovascular coupling (NVC), the physiological coordination between neuronal activity and cerebral blood flow, as a candidate biomarker for brain function and recovery after injury.

A prospective cohort study was performed using simultaneous electroencephalography (EEG) and near-infrared spectroscopy (NIRS) recordings in patients with moderate-to-severe TBI and healthy controls. Wavelet transform coherence (WTC) analysis was …

Factors Involved On The Attribution Of Consciousness To Generative Artificial Intelligence And Its Impact On Trust, Sophia Fernanda Sakakibara Olgini Capello

Honors Undergraduate Theses

This study investigates the cognitive factors influencing the perception of mind in generative artificial intelligence systems, focusing on the role of prior experiences with them, theory of mind (ToM), and the tendency to anthropomorphize. The research examined how these factors predict perceived consciousness in ChatGPT and impact users' trust in this system, specifically exploring: (1) how ToM and anthropomorphism contribute to AI consciousness perception, (2) how prior AI experiences influence consciousness attribution, (3) the relationship between consciousness attribution and trust in AI, and (4) how perceptions of AI consciousness relate to mind perception in other entities. Undergraduates (N= 220) completed …

Juvenile Record Expungement Policy In Illinois, Emma Kudelka

Res Publica - Journal of Undergraduate Research

This policy paper explores juvenile expungement policies and their broader social impact. Research suggests that lenient expungement laws help prevent discrimination in education, housing, and military service, aiding rehabilitation youth offenders' reintegration. The paper begins with a historical overview of Illinois juvenile law, highlighting its shift from punitive to rehabilitative approaches. It then examines key legislation, including the Juvenile Court Act, Juvenile Justice, and Delinquency Prevention Act, and Youth Opportunity and Fairness Act. Illinois's juvenile expungement laws are analyzed, covering eligibility, process, and timeline. A comparative analysis follows, contrasting Illinois' policies with those of California and Florida to emphasize differences …

Role Of Online Health Information Resources In Shaping Self Confidence Of Nursing And Midwifery Students In The Digital Era At Aga Khan University, Tanzania, Getrude Ngowi, Jackline Estomihi Kiwelu

Book Chapters / Conference Papers

Digital technologies have transformed the way people learn in the current age. Innovative multimedia online nursing and midwifery information resources have improved nursing education and brought about adaptive, interactive, and collaborative learning. This study aims to find out whether the online nursing information resources provided at Aga Khan University Tanzania are shaping the self-confidence of nurses and midwives in the digital era, to understand gaps and areas for improvement. This study used both quantitative and qualitative research approach were used. The researchers collecting data using online Google Forms, which were analysed thematically through Atlas ti. The results revealed that persistent …

Redwood National & State Parks Tales, Trails, & Auto Tours, Jerry Rohde, Gisela Rohde, Larry Eifert

Archives & Reprint Series (imprint)

California’s far North Coast and its four redwood parks come alive in this wide-ranging, profusely illustrated guidebook. TALES: from shipwrecks to logging camps to expired elephants, 50 amusing and informative historical accounts describe the region’s most fascinating people, places, and events. TRAILS: “25 favorite hikes” take you through ancient redwood forests, across flower-filled prairies, and along seldom seen sections of the coast. AUTO TOURS: a dozen intriguing drives explore the parks’ highways and byways. PLUS: more than 150 maps and drawings by renowned redwood artist Larry Eifert, extensive lists of plants and wildlife, and an easy-to-use “Quick Guide” that puts …

Ajwa Date Extract (Phoenix Dactylifera L.): Phytochemical Analysis, Antiviral Activity Against Herpes Simplex Virus-I And Coxsackie B4 Virus, And In Silico Study, Ahmad K. Aljohani, Nader A. Maghrabi, Osama M. Alrehili, Abdulaziz S. Alharbi, Rawad S. Alsihli, Abdulrahman M. Alharthe, Rayan S. Albladi, Khalid A. Alosaimi, Bader M. Albadrani, Samar F. Miski, Hossein M. Elbadawy, Bandar D. Alrehaili, Fahd A. Abdelkarem, Modather F. Hussein

Saudi Medical Journal

Objectives: To investigate the phytochemical composition of Ajwa date extract and evaluate its antiviral activity and mechanism of action. Methods: High perfomance liquid chromatography, gas chromatography-mass spectrometry, and liquid chromatography-mass spectrometry were used to analyze the phytochemical profile of Ajwa date extract. The antiviral activity was assessed using the MTT colorimetric assay against herpes simplex virus type I (HSV-I) and coxsackievirus B4 (CVB-4). Assessment of the mechanism of action against HSV-I was carried out using 3 protocols. Molecular docking and quantum chemical calculations were carried out to predict the binding affinities of the identified compounds to viral glycoprotein D. Results: …

Graduate Catalog, Georgia Southern University

Graduate Catalogs

No abstract provided.

Kathy Rutkowski '75-Larry Bazer '85, Kathy Rutkowski, Larry Bazer

Alumni Oral History Project

No abstract provided.

Sir Fig Newton And The Science Of Persistence (2023) By Sonja Thomas, Maughn Rollins Gregory

Middle Grades Books

When twelve-year-old Mira Williams’s companion and confidant, the cat Sir Fig Newton, contracts diabetes, her parents say she may have to give him to someone who can afford his treatment. The resources Mira will need to save Fig and keep him close include ingenuity, family ties, friendships, and the kind of faith she finds can be compatible with science. Thomas’ novel shows a teenager’s sophisticated engagement with complex questions of race, faith, science, and relationships.

Wildful (2024) By Kengo Kurimoto, Maughn Gregory

Middle Grades Books

Kengo Kurimoto’s graphic novel Wildful explores the transformative power of nature and deep attention. Poppy is struggling with her mother’s depression after her grandmother’s passing. Initially absorbed in digital distractions, Poppy is drawn into the wilderness when her dog, Pepper, chases a fox. She meets Rob, a boy who teaches her to observe nature with curiosity and respect—tracking animals, noticing patterns, and sitting in silence. Poppy learns that being in nature can assuage generational grief through a renewed sense of wonder and connection.

Donald Griffin, Cognitive Ethology, And Animal Life Histories, Walter Veit

Animal Sentience

Carolyn Ristau offers a stellar investigative biography of Donald Redfield Griffin and his influence on the science and philosophy of animal minds. This commentary focuses on his aim to study animal minds through an ethological lens—that is, by examining the evolved, adaptive functions of mental capacities and consciousness in natural environments, rather than confining research to controlled laboratory settings. I argue that, far from being romantic, this approach can be firmly grounded in modern life history theory.

Integrating Human And Animal Health In The Stop Spillover Outbreak Scenarios, Kathleen E. Angell, He Julia Bai, Katherine C. Prager, Janetrix H. Amuguni, Felicia B. Nutter, Jonathan D. Gass Jr, David Brett-Major

Journal Articles: Epidemiology

OBJECTIVES: To generate and employ scenarios of sentinel human and animal outbreak cases in local contexts that integrate human and animal health interests and practices and facilitate outbreak risk management readiness.

METHODS: We conducted a scoping review of past outbreaks and the strengths and weaknesses of response efforts in USAID STOP Spillover program countries. This information and iterative query-and-response with country teams and local stakeholders led to curated outbreak scenarios emphasizing One Health human:animal interfaces at sub-national levels.

RESULTS: Two core scenarios were generated adapted to each of 4 countries’ pathogen priorities and workflows in Africa and Asia, anchoring on …

International Society Of Sports Nutrition Position Stand: Β-Hydroxy-Β-Methylbutyrate (Hmb), John A. Rathmacher, Lisa M. Pitchford, Jeffrey R. Stout, Jeremy R. Townsend, Ralf Jäger, Richard B. Kreider, Bill I. Campbell, Chad M. Kerksick, Patrick S. Harty, Darren G. Candow, Brandon M. Roberts, Shawn M. Arent Ph.D., Cscs*D, Fissn, Facsm, Fnak, Douglas S. Kalman, Jose Antonio

Faculty Publications

Position Statement: The International Society of Sports Nutrition (ISSN) bases the following position stand on an analysis of the literature regarding the effects of β-Hydroxy-β-Methylbutyrate (HMB). The following 12 points have been approved by the Research Committee of the Society: 1. HMB is a metabolite of the amino acid leucine that is naturally produced in both humans and other animals. Two forms of HMB have been studied: Calcium HMB (HMB-Ca) and a free acid form of HMB (HMB-FA). HMB-FA appears to lead to increased appearance of HMB in the bloodstream when compared to HMB-Ca, though recent results are mixed. 2. …

Corporeal Property And The Limits Of Nagpra, M. Alexander Pearl

Faculty Articles

No abstract provided.

Subsurface Trespass In The Restatement (Fourth) Of Property: An Appraisal And Alternative Account, Joseph A. Schremmer

Faculty Articles

Building on the scholarly work of leading property theorists Henry Smith and Thomas Merrill, the recently approved Fourth Tentative Draft of the Restatement (Fourth) of Property prescribes treating all entries below ground as ordinary trespasses. That includes entries in the shallow subsurface by building foundations and utility lines, as well as invasions in the deep subsurface by mining shafts, oil and gas wells, and substances injected for disposal and storage. The Restatement comes at an important time in the development of subsurface trespass law, as developers, courts, and policymakers grapple with the growing use of subsurface technologies for horizontal drilling, …

Characterization Of Methylated Histone Modifications During Simian Virus 40 Early Transcription, Jacob Otto Haugen

Theses and Dissertations

Modifications of histone proteins play an important role in transcription. These modifications regulate how chromatin is compacted by the histone proteins and either made available for transcription or prevents transcription machinery from proceeding. The modifications can be added or removed by histone acetyltransferases and histone methyltransferases for the former, and histone deacetylates and demethylases for the latter. To explore the dynamicity of these modifications we used the simple but effective Simian Virus 40 (SV40) model. SV40 continues to be an important tool in understanding eukaryotic transcription. It experiences similar processes as cellular chromatin, utilizing host proteins to propagate its own …

The Chemical Nature Of Colors, Bryant Corbin, Bryant Corbin

Longwood Senior Thesis Proposal

No abstract provided.

2024 Rhode Island Public Laws

Roger Williams University Law Review

No abstract provided.