Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 34441 - 34470 of 733284

Full-Text Articles in Entire DC Network

An Initial Report On The Search For The Missing Gamelan Heritage Of The Sumenep Palace, Madura, East Java-Indonesia, Aris Setiawan, Zulkarnain Mistortoify Jan 2025

An Initial Report On The Search For The Missing Gamelan Heritage Of The Sumenep Palace, Madura, East Java-Indonesia, Aris Setiawan, Zulkarnain Mistortoify

Journal of Urban Culture Research

This research endeavors to locate the long-lost heirloom gamelan from the Sumenep Palace. Since the abolition of aristocratic status in 1883, the Sumenep Palace has lost political and economic legitimacy. To maintain the luxurious lifestyle of the aristocratic court, valuable items, including gamelans, were sold. The heirloom gamelans in the Sumenep Palace are believed to have been gifts from the Mataram Palace, often exchanged during various events, such as marriages. Employing an investigative ethnographic approach, this study gathered data through in-depth interviews with cultural practitioners, palace descendants, and private collectors; direct observation of remaining artifacts; and analysis of historical documents …


Exploring National Identity Through Modern Monumental And Decorative Tapestry Of Kazakhstan, Baurzhan Doszhanov, Ainash Nauryzbayeva, Yerbol Kairanov, Mukhamejan Suleimenov, Malik Mukanov Jan 2025

Exploring National Identity Through Modern Monumental And Decorative Tapestry Of Kazakhstan, Baurzhan Doszhanov, Ainash Nauryzbayeva, Yerbol Kairanov, Mukhamejan Suleimenov, Malik Mukanov

Journal of Urban Culture Research

In the context of technical and global transformations, art persists in articulating national identity. The aim of this study is to analyze in depth the art of monumental decorative tapestry in Kazakhstan, with a focus on its contribution to the search for a new paradigm and national identity in contemporary visual arts. Methods of analyzing and comparing artistic works of tapestry artists of contemporary Kazakhstan were used. This research analyses chosen works and their impact on the cultural environment, demonstrating that current monumental and decorative tapestries in Kazakhstan serve not merely as aesthetic objects but also actively contribute to the …


The Battle Spirit : The Cultural Essence Of Buddhist Temple Murals In Northeast Thailand, Ya-Liang Chang Jan 2025

The Battle Spirit : The Cultural Essence Of Buddhist Temple Murals In Northeast Thailand, Ya-Liang Chang

Journal of Urban Culture Research

The murals found in Buddhist temples across Thailand play a significant role in the country's social fabric and are integral to the safeguarding efforts of Thailand's intangible cultural heritage. The research aims to explore the essence of murals in 24 Buddhist temples in Isan, delving into the principles guiding their creation. The author explores the intrinsic meanings embedded in these murals and deconstructs the cultural essence of Isan through a qualitative study. The investigation reveals the core essence of Isan's murals as the “battle spirit,” intricately woven across individual, societal, and national levels. Serving as conduits for Buddhist teachings on …


Nature Contained – A Practice-Led Art Project : Within The Principles Of Ikebana And On The Nature Of Harmony, Cherie Chai Tze Lo, Sone Simatrang, Eakachat Joneurairatana Jan 2025

Nature Contained – A Practice-Led Art Project : Within The Principles Of Ikebana And On The Nature Of Harmony, Cherie Chai Tze Lo, Sone Simatrang, Eakachat Joneurairatana

Journal of Urban Culture Research

This research redefines unity between art, design and urban architecture, and wellbeing as an active reconciliation and conscious construction. The findings resonate with contemporary creative practices prioritizing audience engagement. A practice-led and process driven design/art project, it explores the notion of harmony through the Japanese Zen of Ikebana (flower arrangement) and Chasitsu (Tea room). Situated in Bangkok, the process incorporates cross-cultural interactions between Thai business life and Japanese meditative traditions. The methodology re-traces Ikebana flowers into static lines of a steel sculpture. Placed within a furniture design showroom’s internal courtyard, the installation is activated dialogically through a survey that probes …


New Generation Of Sangkhalok Figurines, Chanakarn Semachai Jan 2025

New Generation Of Sangkhalok Figurines, Chanakarn Semachai

Journal of Urban Culture Research

This research on the New Generation of Sangkhalok Figurines aims to investigate the history and craftsmanship of Sangkhalok production, highlighting its distinctive features to guide future developments. It seeks to collect contemporary concepts that resonate with today's audience by engaging the younger generation to establish set guidelines for creating figurines of the new generation. The study employs participatory learning theory, involving a group of Generation Z participants aged 8-15 from three schools. These participants designed figurines based on their ideas, which were then evaluated by experts to determine the best design principles. The refined designs are being incorporated into the …


Ensemble Music For Social And Emotional Development : A Case Study Of Primary School Children In A Suburban Malaysian Chinese Community, Florence Kuek, Siew May Cheng, Anna Phang, Wen Fen Beh Jan 2025

Ensemble Music For Social And Emotional Development : A Case Study Of Primary School Children In A Suburban Malaysian Chinese Community, Florence Kuek, Siew May Cheng, Anna Phang, Wen Fen Beh

Journal of Urban Culture Research

Music forms part of the Malaysian national curriculum for primary education, but music education is often compromised by low community interest, resulting in children’s underexposure to musical training. This qualitative study examines the inclusivity, creativity, and sustainability of a community-initiated children’s choral-instrument ensemble established as an after-school, weekly activity in suburban Malaysia, where members were recruited from lower- to middle-income families, and had little means to pursue music otherwise. Data were collected from class observations, children’s “before-after” drawings, and semi-structured interviews with the stakeholders. The trustworthiness and validity were ensured through inter-rating, member checks, and data triangulation. The findings revealed …


Problems Of Contemporary Art In The Regions Of Great Altai, Yelena Lichman, Mikhail Popandopulo, Abdrashid Raimbergenov, Abdulkhamit Raimbergenov, Adilgali Sagimbayev Jan 2025

Problems Of Contemporary Art In The Regions Of Great Altai, Yelena Lichman, Mikhail Popandopulo, Abdrashid Raimbergenov, Abdulkhamit Raimbergenov, Adilgali Sagimbayev

Journal of Urban Culture Research

The relevance of the study is due to the fact that at present the topic of modern art is studied all over the world. The purpose of study is the complex study of factors that influence the activities of young artists in the art sector, their genre preference and the choice of unique forms to convey their own thoughts. To achieve this goal, theoretical and empirical methods such as statistical analysis, synthesis, induction and deduction were mainly used. The result of the research was a full analysis of the works of modern Kazakh, Mongolian, Chinese and Uzbek artists working in …


Ancient Service Systems In Historic Houses And Their Contribution To Sustainable Urban Development : The Case Of Architect Sinan’S House, Gülşen Dişli, Gül Gediri-Gökçen Jan 2025

Ancient Service Systems In Historic Houses And Their Contribution To Sustainable Urban Development : The Case Of Architect Sinan’S House, Gülşen Dişli, Gül Gediri-Gökçen

Journal of Urban Culture Research

The service systems of historic buildings, namely, heating, ventilation, cooling, lighting, and drainage play a critical role in the life cycle of buildings and sustainable urban development to preserve traditional knowledge systems. Therefore, a detailed investigation is required before, during, and after any preservation activity to ensure the historic integrity. Hence, this research aims to identify, investigate, and research the original service systems of a historic building, namely, the Architect Sinan's house in Ağırnas, Türkiye, to reveal and sustain these original passive survivability details to future generations and to learn from these details in present constructions. Main methods were site …


Dean's Report- Winter-Spring 2025, Marina K. Holz Jan 2025

Dean's Report- Winter-Spring 2025, Marina K. Holz

GSBMS Dean’s Report

No abstract provided.


Chronic Alcohol Consumption Induces Phenotypic And Functional Alterations Consistent With A Hyper-Inflammatory State In Peripheral Blood Mononuclear Cell-Derived Microglia In A Rhesus Macaque Model, Hami Hemati, Madison B. Blanton, Heather E. True, Jude Koura, Rupak Khadka, Kathleen A. Grant, Ilhem Messaoudi Jan 2025

Chronic Alcohol Consumption Induces Phenotypic And Functional Alterations Consistent With A Hyper-Inflammatory State In Peripheral Blood Mononuclear Cell-Derived Microglia In A Rhesus Macaque Model, Hami Hemati, Madison B. Blanton, Heather E. True, Jude Koura, Rupak Khadka, Kathleen A. Grant, Ilhem Messaoudi

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Alcohol-induced dysregulation of microglial activity is associated with neuroinflammation, cognitive decline, heightened risk for neurodegenerative diseases, alcohol dependence, and escalation of alcohol drinking. Given the challenge of longitudinally sampling primary microglia, we optimized an in vitro method to differentiate peripheral blood mononuclear cells (PBMC) from rhesus macaque (RM) into induced microglia-like cells (RM-iMGLs). The RM-iMGLs displayed transcriptional profiles distinct from monocyte progenitors and closely resembling primary microglia. Notably, morphological features showed that differentiated RM-iMGLs derived from subjects with chronic alcohol consumption (CAC), while bigger, exhibited a bipolar-like morphology. Additionally, dysregulation in key inflammatory and regulatory markers, along with increased baseline …


The Wild Dark Or, La Oscuridad Salvaje: Illuminating Identity Through Failure, Worley B. Gierhart Jan 2025

The Wild Dark Or, La Oscuridad Salvaje: Illuminating Identity Through Failure, Worley B. Gierhart

Undergraduate Theses

This thesis, "The Wild Dark or, La oscuridad salvaje: Illuminating Identity Through Failure," explores how the narrative power of darkness can serve as a catalyst for profound self-discovery, particularly in the aftermath of significant failure. Drawing upon literary analysis and the author's personal experience of shifting academic paths, the study examines how confronting metaphorical darkness allows for a critical rebuilding of identity and self-concept. The play referenced in the title, "The Wild Dark or, La oscuridad salvaje," serves as a central point of analysis, investigating the interplay of theme, setting, and scenario in depicting this transformative process. By engaging with …


Risk Factors For Unexplained Early Neurological Deterioration After Intravenous Thrombolysis: A Meta-Analysis, J. Li, C.L. Zhu, C.Y. Zhang, L.M. Li, R. Liu, S. Zhang, M.L. He Jan 2025

Risk Factors For Unexplained Early Neurological Deterioration After Intravenous Thrombolysis: A Meta-Analysis, J. Li, C.L. Zhu, C.Y. Zhang, L.M. Li, R. Liu, S. Zhang, M.L. He

Neurosciences

ABSTRACT Objectives: To explore the risk factors of unexplained early neurological dererioration (END) after IVT, and explore the underlying mechanisms by which these factors contribute to END onset and progression. Methods: We performed a systematic literature search in accordance with PRISMA guidelines, utilizing PubMed, WOS, and EMBASE databases to identify all relevant studies investigating END in AIS patients who received IVT within 4.5 hours of symptom onset. Results: Out of 2,613 reviewed records, 16 were included in this meta-analysis. The quantitative synthesis of data regarding the incidence of END in acute ischemic stroke (AIS) patients with IVT was 12% (95% …


Bailing Out Biometrics, Chinmayi Sharma, Elijah Gordon Jan 2025

Bailing Out Biometrics, Chinmayi Sharma, Elijah Gordon

Faculty Scholarship

In 2023, hackers breached 23andMe and extracted the biometric and genealogical data of nearly seven million people. By 2025, that data-originally offered up in the spirit of medical discovery and consumer empowerment-was being auctioned off in bankruptcy court as a corporate asset. The breach exposed more than technical lapses or governance failures. It revealed a structural gap in how the law understands, regulates, and protects biometric identity. Biometric data is intimate, immutable, and implicates human dignity and autonomy. And yet, the legal frameworks most often tasked with protecting it-tort, contract, and even modern privacy statutes-have consistently failed to impose meaningful …


Neutrosophic Twofold Superhyperalgebra And Anti Superhyperalgebra, Takaaki Fujita, Florentin Smarandache Jan 2025

Neutrosophic Twofold Superhyperalgebra And Anti Superhyperalgebra, Takaaki Fujita, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

Neutrosophic Sets are conceptual frameworks designed to address uncertainty. A Neutrosophic TwoFold Algebra is a hybrid algebraic structure defined over a neutrosophic set, combining classical algebraic operations with neutrosophic components. Concepts such as Hyperalgebra and Superhyperalgebra extend classical Algebra using Power Sets and 𝑛-th powersets. Additionally, structures such as NeutroAlgebra and AntiAlgebra have been defined in recent y ears. This paper explores several related concepts, including TwoFold SuperhyperAlgebra and Anti SuperhyperAlgebra.


Minimal Rationality And The Law Of Evidence, Ronald J. Allen, Michael S. Pardo, William J. Lawrence, Christopher K. Smiciklas Jan 2025

Minimal Rationality And The Law Of Evidence, Ronald J. Allen, Michael S. Pardo, William J. Lawrence, Christopher K. Smiciklas

Journal of Criminal Law and Criminology

For more than a century, one of the pillars upon which the law of evidence was thought to rest is that the primary (although by no means exclusive) objective of the law of evidence is to further accurate fact-finding by maximizing the rationality of the evidentiary process. The crux of this pillar is that the law of evidence increases rationality (and thereby increases accuracy) through admissibility rules that (1) require reliable evidence, and (2) behave paternalistically toward jurors and their cognitive abilities. This Article aims to supplant this pillar by showing that the law of evidence pursues minimal, not maximal, …


Determining The Content And Meaning Of Foreign Law: The Approach Of The New Third Restatement Of Conflict Of Laws, Christopher A. Whytock Jan 2025

Determining The Content And Meaning Of Foreign Law: The Approach Of The New Third Restatement Of Conflict Of Laws, Christopher A. Whytock

Emory International Law Review

No abstract provided.


Health Measures And Willingness To Pay For Internet Services, Maysam Rabbani, Cari A. Bogulski, Corey J. Hayes Jan 2025

Health Measures And Willingness To Pay For Internet Services, Maysam Rabbani, Cari A. Bogulski, Corey J. Hayes

Department of Economics Faculty Scholarship and Creative Works

Introduction: With the rapid adoption of telehealth services, health measures are increasingly tied to internet access. However, there is limited literature on how internet connectivity correlates to health measures and health care utilization. We examined the links between willingness to pay (WTP) for internet services and health measures, namely, health insurance type, general health, physical health, mental health, health literacy, and cost/transportation barriers to health care access. Methods: We designed a custom survey and collected 5, 200 responses in four U.S. states. We implemented a stratified conjoint analysis to estimate the WTP for internet speed and quality and its connections …


Digital Threads: Fashion Design With Clo3d, Maya Herring Jan 2025

Digital Threads: Fashion Design With Clo3d, Maya Herring

Theses

CLO3D (CLO) has emerged as a prominent software service within the fashion industry, molding the conceptualization and development of 3D fashion designs. By eliminating the constraints of customary manufacturing processes and real-life production costs, CLO equips designers with tools to bring their fashion garments and designs to life. This study aims to explore the capabilities of CLO software by developing five digital bridal dresses while also examining the learning curve, challenges, and benefits associated with its usage. The objective is to identify how CLO can provide aspiring fashion designers with the tools to produce high-quality designs without traditional training.

By …


Spirituality, Social Work Practice, And Sustainable Development, Chathapuram Ramanathan, Srilatha Juvva, Nathan Stephens, Anna M. Scheyett, Subhabrata Dutta Jan 2025

Spirituality, Social Work Practice, And Sustainable Development, Chathapuram Ramanathan, Srilatha Juvva, Nathan Stephens, Anna M. Scheyett, Subhabrata Dutta

Faculty Publications - Social Work

Based on human experience and history we know faith and culture are distinct and different. Cultural expression is a fundamental aspect of one’s identity and a human right that must be protected. Culture is a universal phenomenon, that is shaped primarily by one’s socialization. All people have a culture and may belong to a particular faith/spiritual tradition. They may also relate to others who belong to a cultural group or identify with a particular faith/spiritual tradition. To live peacefully we must strive to understand each other’s cultural, faith-based, spiritual realities as well as methods of conflict resolution and survival stories. …


The Advertising Pipeline: Priming Today’S Youth To Be Tomorrow’S Heavy Rollers, Alison Opdyke Jan 2025

The Advertising Pipeline: Priming Today’S Youth To Be Tomorrow’S Heavy Rollers, Alison Opdyke

Student Works

No abstract provided.


Bat Genomes Illuminate Adaptations To Viral Tolerance And Disease Resistance, Ariadna E. Morales, Yue Dong, Thomas Brown, Kaushal Baid, Dimitrios Georgios Kontopoulos, Victoria Gonzalez, Zixia Huang, Alexis Walid Ahmed, Arkadeb Bhuinya, Leon Hilgers, Sylke Winkler, Graham Hughes, Xiaomeng Li, Ping Lu, Yixin Yang, Bogdan M. Kirilenko, Paolo Devanna, Tanya M. Lama, Yomiran Nissan, Martin Pippel, Liliana M. Dávalos, Sonja C. Vernes, Sebastien J. Puechmaille, Stephen J. Rossiter, Yossi Yovel, Joseph B. Prescott, Andreas Kurth, David A. Ray, Burton K. Lim, Eugene Myers, Emma C. Teeling, Arinjay Banerjee Jan 2025

Bat Genomes Illuminate Adaptations To Viral Tolerance And Disease Resistance, Ariadna E. Morales, Yue Dong, Thomas Brown, Kaushal Baid, Dimitrios Georgios Kontopoulos, Victoria Gonzalez, Zixia Huang, Alexis Walid Ahmed, Arkadeb Bhuinya, Leon Hilgers, Sylke Winkler, Graham Hughes, Xiaomeng Li, Ping Lu, Yixin Yang, Bogdan M. Kirilenko, Paolo Devanna, Tanya M. Lama, Yomiran Nissan, Martin Pippel, Liliana M. Dávalos, Sonja C. Vernes, Sebastien J. Puechmaille, Stephen J. Rossiter, Yossi Yovel, Joseph B. Prescott, Andreas Kurth, David A. Ray, Burton K. Lim, Eugene Myers, Emma C. Teeling, Arinjay Banerjee

Biological Sciences: Faculty Publications

Zoonoses are infectious diseases transmitted from animals to humans. Bats have been suggested to harbour more zoonotic viruses than any other mammalian order1. Infections in bats are largely asymptomatic2,3, indicating limited tissue-damaging inflammation and immunopathology. To investigate the genomic basis of disease resistance, the Bat1K project generated reference-quality genomes of ten bat species, including potential viral reservoirs. Here we describe a systematic analysis covering 115 mammalian genomes that revealed that signatures of selection in immune genes are more prevalent in bats than in other mammalian orders. We found an excess of immune gene adaptations in the ancestral chiropteran branch and …


2025 Faculty Summer Seminar - The Living Word Of God: Still Alive Today?, Center For Catholic Studies, Seton Hall University Jan 2025

2025 Faculty Summer Seminar - The Living Word Of God: Still Alive Today?, Center For Catholic Studies, Seton Hall University

Center for Catholic Studies Faculty Seminars and Core Curriculum Seminars

About the 2025 Faculty Seminar - p.6

Josephine De Vito - p.10 Understanding the Blessed Virgin Mary in the Holy Scriptures

Elizabeth Brewer Redwine - p.13 Reading and Listening in Difficult Times: Classroom Strategies

Judith Stark - p.18 Beyond Genesis 1-3: The Many Ways to Conceptualize Nature

Gloria Thurmond - p.25 Study to Show Thyself Approved

John P. Wargacki - p.29 Jacob Marley as 'Intercessor" in Ebenezer Scrooge's Journey of Transformation in Charles Dickens's A Christmas Carol

Seton Hall University Statement: The Catholic Intellectual Tradition – p.32

About the Authors -p.35


The Effectiveness Of Vivistim On Ue Function Post Chronic Ischemic Stroke, Chelsea G. Tucker Jan 2025

The Effectiveness Of Vivistim On Ue Function Post Chronic Ischemic Stroke, Chelsea G. Tucker

Occupational Therapy Doctorate Capstone Posters

The purpose of this capstone project was to learn about a new technology, Vivistim, as it enhances upper extremity function post chronic ischemic stroke through vagus nerve stimulation paired with repetitive task-specific therapy. This project took place at UK Healthcare Outpatient Neurorehabilitation at Cardinal Hill Rehabilitation Hospital in Lexington, Kentucky. The AOTA/ACOTE focus areas for this project included education and clinical practice. Specific goals included to learn about the role of occupational therapy in the outpatient neurorehabilitation setting, research background information for case study including ischemic stroke, motor relearning, vagus nerve stimulation, and Vivistim technology, gather observations for case study, …


Using The Background Of Occupational Therapy To Argue Our Role In Stress Management: Proposed Lines Of Inquiry, Klaire M. Gowins Jan 2025

Using The Background Of Occupational Therapy To Argue Our Role In Stress Management: Proposed Lines Of Inquiry, Klaire M. Gowins

Occupational Therapy Doctorate Capstone Posters

The purpose of this ALE presentation is to present research in support of the development of the Student Stress Management Center (SSMC) at EKU. The researchers’ long-term proposition, beyond the scope of this poster, is to effectively communicate to various audiences the importance and occupation-based characteristics of a Student Stress Management Center for students within the higher education setting. In preparation for that goal, this poster reviews scholarly literature relevant to the field of occupational therapy and its philosophical roots to lay groundwork for clarifying whether and how a revised articulation of the philosophical base is needed, relative to the …


Promoting Inclusion: Creating A Sensory Space In A Local Church, Ashleigh N. Dotson Jan 2025

Promoting Inclusion: Creating A Sensory Space In A Local Church, Ashleigh N. Dotson

Occupational Therapy Doctorate Capstone Posters

This capstone project took place at a local church, The Creek, in London, KY. Specifically, this project took place within the Kid’s church area. The ACOTE focus areas for this project were program development, education, and advocacy. The goals of this Capstone/ALE project were to learn more about and better understand the sensory system and how it works; to create a sensory room for children with disabilities who may need to regulate their sensory system; to create resources and educational guides for adults and volunteers who may be in the sensory room to guide them on the appropriate ways to …


A Dog Tail: To Trust Or Not To Trust, Victoria A. Denishchich, Christa C. Christ Jan 2025

A Dog Tail: To Trust Or Not To Trust, Victoria A. Denishchich, Christa C. Christ

University of South Carolina Upstate Student Research Journal

Trust plays an important role in relationships and social functioning while also influencing communication, cooperation, and emotional well-being. Previous research has found that dogs enhance social relationships, approachability, and perceptions of safety and friendliness in everyday interactions. However, not much is known about how the effect dogs have on perceptions of trust applies when photographs are used. Such info is essential given the amount of online social interaction that occurs in society today. This current study examined whether the presence of a dog in a photo affects our trust levels in strangers. In Study 1, 74 participants viewed photos of …


Inquiries Into The Mycobacterial Caseinolytic Protease System, Felipe Badke D'Andrea Jan 2025

Inquiries Into The Mycobacterial Caseinolytic Protease System, Felipe Badke D'Andrea

Student Theses and Dissertations

Despite progress over the last century, Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains the leading cause of death from an infectious disease worldwide. The high global burden of Mtb, alongside its protracted treatment regimen and insidious rise of multi-drug resistance, underscores the need for non-canonical drug targets and pathways to improve antitubercular chemotherapy. Mtb's success as a pathogen is linked to its ability to infect and evade clearance by the human immune system despite a wide range of noxious host stressors. Along with transcriptional responses, the maintenance of protein homeostasis is critical to this adaptability and pathogenicity. …


Nurture Is Nature: The Molecular Basis Of Caregiver Genotype Effects On Larval Growth And Caste Development In The Clonal Raider Ant, Patrick Konrad Piekarski Jan 2025

Nurture Is Nature: The Molecular Basis Of Caregiver Genotype Effects On Larval Growth And Caste Development In The Clonal Raider Ant, Patrick Konrad Piekarski

Student Theses and Dissertations

The distinction between nature (genetics) and nurture (environment) is blurry, in part because the environment includes the genes of social partners. This is especially evident for parents and their offspring, where genes expressed in one partner profoundly influence the physiology and behavior of the other. Such indirect genetic effects (IGEs) are mediated through social interactions. Although parental care has evolved in many disparate lineages, in most systems it is challenging to delineate the effects of genetics and environment on the phenotypes of caregivers and offspring. This is because most animals with parental care reproduce sexually, meaning each genotype is represented …


Serine Metabolism Leverages The Integrated Stress Response To Direct Stem Cell Fate During Tissue Regeneration, Jesse Stephen Swyer Novak Jan 2025

Serine Metabolism Leverages The Integrated Stress Response To Direct Stem Cell Fate During Tissue Regeneration, Jesse Stephen Swyer Novak

Student Theses and Dissertations

Epidermal stem cells constantly rejuvenate the skin's barrier, which excludes harmful microbes and prevents dehydration. While hair follicle stem cells (HFSCs) normally regenerate hair, they must also reconstruct and thereafter maintain the overlying epidermis upon a barrier breach, such as a wound. How these fate choices are balanced to restore physiologic function to damaged tissue remains poorly understood. Here, I uncover the non-essential amino acid serine as a surprising regulator in this process. Utilizing dietary intervention and HFSC-specific loss-of-function studies, I demonstrate that under serine-depleted conditions HFSCs delay hair growth. Upon injury, serine-restricted HFSCs skew their fate towards epidermal re-epithelialization …


Molecular And Cellular Mechanisms Of Lim Protein Mechanotransduction, Donovan Yong Zhi Phua Jan 2025

Molecular And Cellular Mechanisms Of Lim Protein Mechanotransduction, Donovan Yong Zhi Phua

Student Theses and Dissertations

For tissues to develop and maintain mechanical homeostasis, cells must be able to perceive and respond to mechanical cues in their local environments (mechanosense). While there has been significant progress in understanding the physiological significance of mechanosensation, the mechanisms by which proteins convert mechanical stimuli into biochemical signals (mechanotransduction) are poorly understood. The actin cytoskeleton serves as a nexus for cellular mechanotransduction, generating and transducing forces into intracellular signals that coordinate cell migration, cellular contractility, organelle dynamics, and gene expression. However, our understanding of the molecular mechanisms by which cytoskeletal mechanotransduction is achieved is limited. LIM domain proteins are a …