Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 34351 - 34380 of 733319

Full-Text Articles in Entire DC Network

Performance Assemblages | Research, La Samuelson, Movement Lab Jan 2025

Performance Assemblages | Research, La Samuelson, Movement Lab

Course Materials & Research

No abstract provided.


Man With An Itchy Back, Katherine Schaffer, Nevin Adamski, Brittany Ambrose, Kathleen Anderson Jan 2025

Man With An Itchy Back, Katherine Schaffer, Nevin Adamski, Brittany Ambrose, Kathleen Anderson

Department of Emergency Medicine Faculty Publications

[First paragraph] A 61-year old man with no significant past medical history presented with painful bug bites on his lower back 1 day after a 1.5-week-long visit to Africa. He noticed bug bites on his lower back 3 days ago; since then, they have increased in size and become more painful. He was prescribed doxycycline at urgent care earlier that morning and had taken 1 dose. He is taking prophylactic medications for malaria and has had no fever at home. Vital signs, exquisitely tender papular lesions with a central punctum and surrounding erythema in the bilateral paralumbar regions.


Salinity Tolerance Of Bighead Carp And Its Implications For Dispersal In The Lake Pontchartrain Ecosystem, Alan Katzenmeyer Jan 2025

Salinity Tolerance Of Bighead Carp And Its Implications For Dispersal In The Lake Pontchartrain Ecosystem, Alan Katzenmeyer

Electronic Theses and Dissertations

The introduction of invasive bighead carp (Hypophthalmichthys nobilis) into the Pearl and Pascagoula River systems via the Bonnet Carré Spillway during flood control operations poses a significant threat to these unique ecosystems. This dissertation's experiments investigated the role of salinity in limiting bighead carp dispersal, demonstrating that brackish waters do not necessarily restrict their range as previously assumed. While bighead carp exhibited no significant impairment in swimming performance in salinities at or below 5 ppt, acute and chronic exposure to salinities at 15 ppt proved lethal within 50 hours, representing a critical salinity threshold. Despite mortality at elevated salinities, the …


Storytelling In Context: How Resources Enable And Constrain The Stories Entrepreneurs Tell, John J. Rogers Jan 2025

Storytelling In Context: How Resources Enable And Constrain The Stories Entrepreneurs Tell, John J. Rogers

Electronic Theses and Dissertations

This dissertation investigates how entrepreneurial storytelling is shaped by and shapes its material and cultural context, extending the Theory of Cultural Entrepreneurship (TOCE). While TOCE highlights storytelling as a mechanism through which entrepreneurs construct legitimacy and secure resources by drawing on culturally resonant narratives, prior research has largely overlooked the constraining and enabling role of material resources in this process. This dissertation addresses this gap by examining how context functions, not merely as a backdrop but as a constitutive force in entrepreneurial storytelling. Using ethnographic methods, two studies were conducted at a regenerative farm and processing facility in rural Mississippi. …


A 40-Week Phase 2b Randomized, Multicenter, Double-Blind, Placebo-Controlled Study Evaluating The Safety And Efficacy Of Memantine In Amyotrophic Lateral Sclerosis, Salman Bhai, Todd Levine, Dan Moore, Robert Bowser, Andrew J. Heim, Maureen Walsh, Aziz Shibani, Zachary Simmons, James Grogan, Namita A. Goyal, Raghav Govindarajan, Yessar Hussain, Tania Papsdorf, Tiffany Schwasinger-Schmidt, Nick Olney, Kim Goslin, Michael Pulley, Edward J. Kasarskis, Michael Weiss, Susan W. Katz, Suzan Moser, Duaa Jabari, Omar Jawdat, Jeffrey Statland, Mazen M. Dimachkie, Richard Barohn, Neuromuscular Study Group And Western Als Consortium Memantine Als Study Group Jan 2025

A 40-Week Phase 2b Randomized, Multicenter, Double-Blind, Placebo-Controlled Study Evaluating The Safety And Efficacy Of Memantine In Amyotrophic Lateral Sclerosis, Salman Bhai, Todd Levine, Dan Moore, Robert Bowser, Andrew J. Heim, Maureen Walsh, Aziz Shibani, Zachary Simmons, James Grogan, Namita A. Goyal, Raghav Govindarajan, Yessar Hussain, Tania Papsdorf, Tiffany Schwasinger-Schmidt, Nick Olney, Kim Goslin, Michael Pulley, Edward J. Kasarskis, Michael Weiss, Susan W. Katz, Suzan Moser, Duaa Jabari, Omar Jawdat, Jeffrey Statland, Mazen M. Dimachkie, Richard Barohn, Neuromuscular Study Group And Western Als Consortium Memantine Als Study Group

Neurology Faculty Publications

Introduction: Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease with no known cure, limited treatment options with minimal benefits, and significant unmet need for disease modifying therapies.

Aims: This study investigated memantine's impact on ALS progression, with an additional focus on the effects of memantine on cognitive and behavioral changes associated with the disease.

Methods: A randomized, double-blind, placebo-controlled clinical trial was conducted from December 2018 to September 2020. ALS patients were enrolled in-person and remotely across 13 sites in the United States. Participants were randomized to memantine (20 mg twice daily) or placebo in a 2:1 ratio …


The Supporting Of Teachers Of Experiential Learning, Natalia Noemi Jankowski Jan 2025

The Supporting Of Teachers Of Experiential Learning, Natalia Noemi Jankowski

All Electronic Theses and Dissertations

This literature review investigates best practices for supporting teachers in experiential learning, including project-based, inquiry-based, service, and problem-based approaches. Grounded in constructivist learning theory, the research explores how professional development, mentorship, and administrative structures influence teacher capacity to facilitate authentic, student-centered learning. Emphasis is placed on strategies that sustain experiential practices in traditional school settings. Findings indicate that ongoing coaching, collaborative planning time, and alignment with curriculum standards are critical to teacher success. While challenges remain in implementation, studies affirm that when teachers are well-supported, experiential learning significantly enhances student engagement and achievement. This thesis offers insights to guide schools …


More Than What You Say: Nonverbal Communication In The 21st Century, Stephanie Montgomery Jan 2025

More Than What You Say: Nonverbal Communication In The 21st Century, Stephanie Montgomery

Textbooks

Nonverbal communication is a distinct form of communication, transcending the spoken word. It is communication through our gestures, eye behavior, vocalics, and body language. Nonverbal communication is often misinterpreted, though, because accurate interpretation depends on a variety of skills. This is not an easy or natural ability. However, with education, awareness, and training, errors can be minimized.


Landscape And Environmental Characteristics That Shape Bat Assemblage Activity Across Varying Levels Of Development In North America, Kerrigan Larkin Jan 2025

Landscape And Environmental Characteristics That Shape Bat Assemblage Activity Across Varying Levels Of Development In North America, Kerrigan Larkin

Master's Theses

This study investigates how environmental and landscape characteristics influence bat activity across varying levels of development in South Carolina. Acoustic monitoring was used to passively survey at five sites: Brays Island, Nemours Plantation, Palmetto Bluff, Spring Island, and Sun City. For six months, twenty-four Wildlife Acoustics Song Meter Mini monitors recorded bat calls, which were then analyzed using Kaleidoscope Pro 5.6.8 and SPSS Statistics 29. There were four hypotheses that were tested regarding the relationship between bat activity and environmental factors: temperature, canopy cover, midstory, and artificial light at night (ALAN) to determine if they were correlated. It was found …


You’Re On Fire: Social Skills Training To Increase Sportsmanship For Teenagers With Disabilities, Madeline K. Wainwright Jan 2025

You’Re On Fire: Social Skills Training To Increase Sportsmanship For Teenagers With Disabilities, Madeline K. Wainwright

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

This study presents findings from a multiple probe design that evaluated the effects of social skills training as a method of teaching an increase of good sportsmanship, more particularly compliments of gameplay, for individuals with intellectual disabilities. The research included three U.S. high school students with intellectual disabilities and the data was analyzed across conditions. Following mastery criterion, generalization sessions across contexts were conducted. All participants acquired complimenting behavior through social skills training. However, none of the participants were able to generalize the skill to different contexts. Results and directions for future research regarding generalization in replication and use of …


Evaluating A Naturalistic Language Intervention With Students With Complex Communication Needs In An Elementary Classroom, Kristina M. Johnson Jan 2025

Evaluating A Naturalistic Language Intervention With Students With Complex Communication Needs In An Elementary Classroom, Kristina M. Johnson

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

Communication is an essential skill for all students, but specifically for students with moderate to severe disabilities. Through communication, our students with disabilities express their wants and need, make and maintain relationships, and participate in daily activities at home, school, and in the community. Play is a natural and motivating activity that encourages communication in all settings. Thus, I looked at using naturalistic language intervention (NLI) as an intervention strategy to increase expressive communication skills in my students with expressive language deficits. This project aimed to increase expressive communication skills in three elementary students with moderate to severe disabilities by …


Protective Effects Of Nigella Sativa Against Acrylamide-Induced Toxicity In Submandibular Salivary Glands Of Albino Rats: A Histological And Molecular Study, Salma Awad Taghyan, Elham Fathy Mahmoud, Rasha Mohamed Taha, Mohamed Shamel Jan 2025

Protective Effects Of Nigella Sativa Against Acrylamide-Induced Toxicity In Submandibular Salivary Glands Of Albino Rats: A Histological And Molecular Study, Salma Awad Taghyan, Elham Fathy Mahmoud, Rasha Mohamed Taha, Mohamed Shamel

Dentistry

No abstract provided.


Effects Of Dietary Energy Source And Stress On Equine Intestinal Permeability And Inflammation, Amanda R. Bauman Jan 2025

Effects Of Dietary Energy Source And Stress On Equine Intestinal Permeability And Inflammation, Amanda R. Bauman

Theses and Dissertations--Animal and Food Sciences

Dietary concentrate is often provided to exercising horses to meet energy requirements. However, both high-starch and high-fat diets may be associated with alterations in intestinal barrier function. To investigate this, 32 mature horses were fed one of four isocaloric dietary concentrate treatments (n = 8 per treatment): 1) a concentrate with cracked corn providing 4 g starch⋅kg BW-1⋅d-1 and 0.2 g fat⋅kg BW-1⋅d-1 (CC), 2) a concentrate with puffed corn providing 4 g starch⋅kg BW-1⋅d-1 and 0.2 g fat⋅kg BW-1⋅d-1 (PC), 3) a concentrate with puffed corn and …


Metabolic And Barrier Function In Response To Β-Caryophyllene In Intestinal Epithelial Cells, Hannah Scroggins Jan 2025

Metabolic And Barrier Function In Response To Β-Caryophyllene In Intestinal Epithelial Cells, Hannah Scroggins

Theses and Dissertations--Animal and Food Sciences

Butyrate, a short-chain fatty acid, regulates cellular metabolism and energy status in intestinal epithelial cells. β-caryophyllene (BCP) is a plant-derived compound that may provide advantageous effects on intestinal barrier function and nutrient utilization. The goal of this thesis was to investigate the effects of BCP on butyrate utilization and metabolism in intestinal epithelial cells. Throughout this thesis, Caco-2 cells in hanging inserts in multi-well plates were used as a model for the intestinal barrier. One study was conducted to investigate the effect of BCP on butyrate utilization and barrier function in intestinal epithelial cells. A second study aimed to elucidate …


Comparison Of Sheep And Cattle Rumen Microbiological And Physiological Responses To An Abrupt Transition From A High-Forage To A High-Concentrate Diet, Katherine Purvis Jan 2025

Comparison Of Sheep And Cattle Rumen Microbiological And Physiological Responses To An Abrupt Transition From A High-Forage To A High-Concentrate Diet, Katherine Purvis

Theses and Dissertations--Animal and Food Sciences

Sheep and cattle are often used interchangeably due to having the same gastrointestinal anatomy; however literature directly comparing the two species is minimal. Previous in vitro studies have pointed towards potential species differences in rumen carbohydrate utilization and acidosis susceptibility. The objective of this study was to evaluate in vivo microbiological and physiological responses of wethers and steers when abruptly transitioned from a high-forage to a high-concentrate diet. We hypothesized there are differences between species in response to abrupt dietary transition with respect to intake, rumen microbiology, and the rumen environment. Individually housed, rumen cannulated purebred Polypay wethers (n = …


Red Palm Oil Mitigates Vitamin A Deficiency In Parotid Salivary Glands An Animal Study, Sara Elbanna, Mohamed Mansy, Mohamed Shamel, Mahmoud Al Ankily, Caroline Maged Massieh Jan 2025

Red Palm Oil Mitigates Vitamin A Deficiency In Parotid Salivary Glands An Animal Study, Sara Elbanna, Mohamed Mansy, Mohamed Shamel, Mahmoud Al Ankily, Caroline Maged Massieh

Dentistry

No abstract provided.


An Exploratory Approach To Understanding Assessment Errors On Measures Of Executive Functioning, Gurjot Mondair Jan 2025

An Exploratory Approach To Understanding Assessment Errors On Measures Of Executive Functioning, Gurjot Mondair

PCOM Psychology Dissertations

The global risk of dementia due to longer lifespans and increased medical interventions necessitates accurate diagnosis of cognitive decline. Thus, the utilization of neuropsychological testing to diagnose disorders of cognitive decline should seek to ascertain multiple data, including success/failure of cognitive tasks and evaluation of error patterns. The purpose of this study was to examine the frequency of executive function (EF) errors across diagnoses of cognitive decline (age-related cognitive decline [ARCD], mild cognitive impairment [MCI], vascular dementia [VaD], frontotemporal dementia [FTD], Lewy body dementia [LBD], and Alzheimer’s disease [AD]) and to examine whether the specific types of EF errors (intrusion, …


Examining Factors Considered In Autism Specialization Among Early Career Psychologists, Tarie Taylor Jan 2025

Examining Factors Considered In Autism Specialization Among Early Career Psychologists, Tarie Taylor

PCOM Psychology Dissertations

Families in the United States often face significant delays in accessing autism-related healthcare services. Despite routine autism-specific screenings at 18- and 24-month pediatric visits, there is still, on average, a gap of over two years before families receive an autism diagnosis (Chen et al., 2023). Although the literature cites factors like limited access to specialized providers and a lack of autism-specific services contributing to this delay (Cantor et al., 2020), further research is needed to explore the underlying factors influencing providers' decisions to specialize in an autism-related healthcare service. Thus, the current study used a mixed-methods, internet-based survey to examine …


Examining Executive Functions And Semantic Organization Across Occupation Types, Emily Murtha Jan 2025

Examining Executive Functions And Semantic Organization Across Occupation Types, Emily Murtha

PCOM Psychology Dissertations

This study examined the relationship between executive functioning, semantic organization, and occupational classification, focusing on whether individuals in professional roles (as defined by the Career Occupational Preference System; COPS) demonstrated stronger executive functioning and semantic organization during memory recall than those in non-professional roles. Participants completed the Booklet Category Test (BCT) to assess executive functioning, the California Verbal Learning Test–Second Edition (CVLT-II) to evaluate semantic organization using short-delay free recall (SDFR), and the Wechsler Adult Intelligence Scale–Fourth Edition (WAIS-IV) to measure IQ. Results showed no significant associations among the main variables. While higher BCT performance was linked to greater use …


Rethinking Mandatory State Bars, Leslie C. Levin Jan 2025

Rethinking Mandatory State Bars, Leslie C. Levin

Faculty Articles and Papers

Mandatory state bars were originally established to better regulate lawyers, advance the profession's interests, and protect the public. Today, however, renewed uncertainty about their constitutionality and questions about what these bars can do and say has led to a spate of litigation against them. This is therefore a good time to rethink the wisdom of maintaining these bars. The Article first describes the unsettled state of the law. It then notes that due to the constraints courts have placed on mandatory bars, some cannot perform traditional bar functions, such as proposing improvements in the substantive law. These bars cannot defend …


New Observations Of Common Snook, Centropomus Undecimalis, In Mississippi Coastal Waters, With A Summary Of Local Records, Tiffany A. Weidner, William C. Tilley, Brooke Doucet, Angelos Apeitos, Eric A. Saillant, James S. Franks, Jeremy M. Higgs Jan 2025

New Observations Of Common Snook, Centropomus Undecimalis, In Mississippi Coastal Waters, With A Summary Of Local Records, Tiffany A. Weidner, William C. Tilley, Brooke Doucet, Angelos Apeitos, Eric A. Saillant, James S. Franks, Jeremy M. Higgs

Gulf and Caribbean Research

No abstract provided.


Early Season Tropical Cyclones Affect Birds Breeding On A Barrier Island, Theodore J. Zenzal Jr., Amanda N. Anderson, Brock Geary, Jessica Schulz, Robert C. Dobbs, Wylie C. Barrow Jr., James H. Waddle Jan 2025

Early Season Tropical Cyclones Affect Birds Breeding On A Barrier Island, Theodore J. Zenzal Jr., Amanda N. Anderson, Brock Geary, Jessica Schulz, Robert C. Dobbs, Wylie C. Barrow Jr., James H. Waddle

Gulf and Caribbean Research

Animal populations often experience acute natural disturbances, most of which are connected to short—term weather events. Occurrences of early—season tropical cyclones during the peak of the avian breeding season are likely to increase with climate change, which can substantially impact populations of coastal breeding birds at multiple scales. To understand the acute impacts of severe tropical cyclones, we investigated how abundances of breeding birds changed before and after 4 early season named tropical cyclones on a barrier island in the Gulf of Mexico. We detected a change in pre— versus post—storm numbers of breeding birds after 2 out of 4 …


Presence Of Potential Nursery Habitat For The Lemon Shark In Mississippi Coastal Waters, Lindsay K. Bomgardner, P. O. Grammer, Angie Hoover, Anna Millender, Jeremy Higgs, Jill M. Hendon, Michael J. Andres Jan 2025

Presence Of Potential Nursery Habitat For The Lemon Shark In Mississippi Coastal Waters, Lindsay K. Bomgardner, P. O. Grammer, Angie Hoover, Anna Millender, Jeremy Higgs, Jill M. Hendon, Michael J. Andres

Gulf and Caribbean Research

No abstract provided.


Ina Scuba: Mobilization Of French West Indies Scuba Diving Clubs To Rapidly Improve Knowledge On Threatened Marine Species. Case Of The White-Spotted Eagle Ray (Aetobatus Narinari)., Océane Beaufort, Rocio Prieto González Jan 2025

Ina Scuba: Mobilization Of French West Indies Scuba Diving Clubs To Rapidly Improve Knowledge On Threatened Marine Species. Case Of The White-Spotted Eagle Ray (Aetobatus Narinari)., Océane Beaufort, Rocio Prieto González

Gulf and Caribbean Research

The White—Spotted Eagle Ray (Aetobatus narinari), listed as Endangered on the IUCN Red List since 2021, is experiencing alarming population declines, underscoring the urgent need for targeted conservation efforts. This species, which plays a vital ecological role in marine food webs, has biological and ecological characteristics that make it particularly vulnerable to habitat degradation and anthropogenic pressures, particularly fishing, tourism, and maritime traffic. In the French West Indies (FWI), the paucity of data on the White—Spotted Eagle Ray remains a major obstacle to the development of effective, island—specific conservation strategies. To address this gap, the INA Scuba participatory …


Designing A Tpack-Based Mobile Learning Model For Biology Education Using Nominal Group Techniques, Cik Jamaliah Abd Manaf, Shakinaz Desa, Muhammad Ikhwan Mat Saad, Helen Crompton Jan 2025

Designing A Tpack-Based Mobile Learning Model For Biology Education Using Nominal Group Techniques, Cik Jamaliah Abd Manaf, Shakinaz Desa, Muhammad Ikhwan Mat Saad, Helen Crompton

STEMPS Faculty Publications

Mobile learning (m-learning) enhances STEM education, particularly in biology, by supporting visualization and interaction. However, a structured framework integrating technological, pedagogical, and content knowledge (TPACK) is essential. This study designs a TPACK-based mobile learning model for biology using the Nominal Group Technique (NGT). A workshop with 10 experts identified seven key components and 67 elements, with nine elements rejected due to low consensus. The validated framework will guide model development using Interpretive Structural Modelling (ISM) to enhance critical thinking, collaboration, and digital citizenship, ultimately fostering effective mobile learning environments for biology education.


Sex-Dependent Changes In Risk-Taking Predisposition Of Rats Following Space Radiation Exposure, Elliot Smits, Faith E. Reid, Ella N. Tamgue, Paola Alvarado Arriaga, Charles Nguyen, Richard A. Britten Jan 2025

Sex-Dependent Changes In Risk-Taking Predisposition Of Rats Following Space Radiation Exposure, Elliot Smits, Faith E. Reid, Ella N. Tamgue, Paola Alvarado Arriaga, Charles Nguyen, Richard A. Britten

Department Radiation Oncology & Biophysics Faculty Publications

The Artemis missions will establish a sustainable human presence on the Moon, serving as a crucial steppingstone for future Mars exploration. Astronauts on these ambitious missions will have to successfully complete complex tasks, which will frequently involve rapid and effective decision making under unfamiliar or high-pressure conditions. Exposure to low doses of space radiation (SR) can impair key executive functions critical to decision making. This study examined the effects of exposure to 10 cGy of Galactic Cosmic Ray simulated radiation (GCRsim) on decision-making performance in male and female rats with a naturally low predisposition for risk-taking (RTP) prior to exposure. …


A Two-Hit Model Of Executive Dysfunction: Simulated Galactic Cosmic Radiation Primes Latent Deficits Revealed By Sleep Fragmentation, Richard A. Britten, Ella N. Tamgue, Paola Arriaga Alvarado, Arriyam S. Fesshaye, Larry D. Sanford Jan 2025

A Two-Hit Model Of Executive Dysfunction: Simulated Galactic Cosmic Radiation Primes Latent Deficits Revealed By Sleep Fragmentation, Richard A. Britten, Ella N. Tamgue, Paola Arriaga Alvarado, Arriyam S. Fesshaye, Larry D. Sanford

Department Radiation Oncology & Biophysics Faculty Publications

Future Artemis-class missions to Mars will expose astronauts to prolonged space radiation (SR), sleep disruption, and operational demands requiring greater autonomy, placing decision making and executive function at heightened risk. Both SR and sleep fragmentation (SF) independently impair cognition, yet their combined effects remain poorly understood. Using the Associative Recognition Memory and Interference (ARMIT) task, we assessed cognitive performance in male rats exposed to 10 cGy of Galactic Cosmic Ray simulation (GCRsim), SF, or both. Under well-rested conditions, GCRsim-exposed rats exhibited overt deficits in the C.1.2 stage, performing at chance when reinforcement contingencies shifted, consistent with impaired cognitive flexibility. In …


Phytochemical And Nutritional Composition Of Vernonia Amygdalina: Antioxidant, Antidiabetic Efficacy, And Hematological Benefits, Hassan A. Adewuyi, Messiah Atapia, Emmanuel Ochonung, Sakariyau A. Waheed, Adebimpe H. Oluwatoyin, Chizoba V. Obunadike, Adeleye A. Edema, Samad Hussein, Usman A. Mohammed, Kevin L. Sebastine, Tolulope O. Jaiyeola Jan 2025

Phytochemical And Nutritional Composition Of Vernonia Amygdalina: Antioxidant, Antidiabetic Efficacy, And Hematological Benefits, Hassan A. Adewuyi, Messiah Atapia, Emmanuel Ochonung, Sakariyau A. Waheed, Adebimpe H. Oluwatoyin, Chizoba V. Obunadike, Adeleye A. Edema, Samad Hussein, Usman A. Mohammed, Kevin L. Sebastine, Tolulope O. Jaiyeola

Chemistry & Biochemistry Faculty Publications

Vernonia amygdalina, a traditionally used medicinal plant, has been purported to possess health-promoting properties. The aim of this study is to investigate the phytochemical and nutritional composition of V. amygdalina, evaluate its antioxidant and antidiabetic efficacy, and assess its hematological benefits. Phytochemical screening, proximate analysis, antioxidant assays (DPPH, ABTS), antidiabetic evaluations in treptozotocin induced diabetic rats, and hematological assessments were conducted according to standard protocol. V. amygdalina exhibited a rich phytochemical profile, comprising flavonoids, phenolic acids, and terpenoids, alongside significant antioxidant activity (IC50 = 12.5 μg/mL) and complete source of protein. Proximate analysis revealed high protein (21.1%) and …


Evaluating The Chemical Reactivity Of Wildfire-Derived Dissolved Organic Molecules: Glutathione Binding Through Kendrick Mass Defect Analysis, Hannah M. Hamontree, Patrick G. Hatcher Jan 2025

Evaluating The Chemical Reactivity Of Wildfire-Derived Dissolved Organic Molecules: Glutathione Binding Through Kendrick Mass Defect Analysis, Hannah M. Hamontree, Patrick G. Hatcher

Chemistry & Biochemistry Faculty Publications

The emerging risks to organisms of pyrogenic-derived dissolved organic matter (PyDOM) from forest fires are of concern due to its toxic and mutagenic potential (e.g., pro-oxidative responses in fauna through the depletion of glutathione, a nitrogen- and sulfur-containing tripeptide found in cells). This study simulates this phenomenon in a laboratory setting by identifying bonding between reduced l-glutathione and organic molecules in leachates from environmentally weathered biomass samples (charred and uncharred) using Kendrick Mass Defect (KMD) analysis from formula lists obtained from negative-mode electrospray ionization-Fourier transform-ion cyclotron resonance-mass spectrometry ((-)ESI-FT-ICR-MS). These formula lists reveal a 10-fold increase in nitrogen- and sulfur-containing …


Clostridioides Difficile Infection Study Models And Prospectives For Probing The Microbe-Host Interface, Tatiana Zvonareva, David S. Courson, Erin B. Purcell Jan 2025

Clostridioides Difficile Infection Study Models And Prospectives For Probing The Microbe-Host Interface, Tatiana Zvonareva, David S. Courson, Erin B. Purcell

Chemistry & Biochemistry Faculty Publications

Clostridioides difficile infection (CDI) is an urgent public health threat with a high rate of recurrence and limited treatment options. In vivo models have been indispensable in understanding CDI pathophysiology and establishing treatment protocols and continue to be essential in pre-clinal testing. More importantly, in vivo models offer the opportunity to probe the complex systemic host response to the microbe, which is impossible to recapitulate in vitro. Nonetheless, constraints related to the availability of animal models, cost, ethical considerations, and regulatory control limit their accessibility for basic research. Furthermore, physiological and habitual divergences between animal models and humans often result …


Antihypertensive Potential Of Euphorbia Hirta And Leptadenia Hastata In Adrenaline-Induced Wistar Rats, Fagbohun Oyenike Bushirat, Emmanuel Ogar Ochonung, Messiah Innocent Atapia, Hassan Abdulsalam Adewuyi, Sakariyau Aido Waheed, Adebimpe Oluwatoyin Hameedah, Chizoba Victory Obunadike, Adeleye Adegboyega Edema, Samad Hussein, Abiola Mohammed Usman, Tolulope Olukayode Jaiyeola Jan 2025

Antihypertensive Potential Of Euphorbia Hirta And Leptadenia Hastata In Adrenaline-Induced Wistar Rats, Fagbohun Oyenike Bushirat, Emmanuel Ogar Ochonung, Messiah Innocent Atapia, Hassan Abdulsalam Adewuyi, Sakariyau Aido Waheed, Adebimpe Oluwatoyin Hameedah, Chizoba Victory Obunadike, Adeleye Adegboyega Edema, Samad Hussein, Abiola Mohammed Usman, Tolulope Olukayode Jaiyeola

Chemistry & Biochemistry Faculty Publications

Background: Hypertension is a major public health concern worldwide, contributing to cardiovascular morbidity and mortality. The use of plant-based therapies, such as Euphorbia hirta and Leptadenia hastata, has gained attention for their potential antioxidant, anti-hyperlipidemic, and organ-protective effects.

Objectives: This study aimed to investigate the phytotherapeutic approach to hypertension using E. hirta and L. hastata extracts in adrenaline-induced hypertensive Wistar rats

Methods: Utilizing an adrenaline-induced hypertensive rat model, we assessed the effects of E. hirta and L. hastata leaf extracts (50, 100, and 200 mg/kg) on systolic blood pressure, renal function, lipid metabolism, and hematological parameters.

Results: Antioxidant activity: …