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Computational Study Of Redox-Active Protein Residues And Biological Proton-Coupled Electron Transfer, Qiwen Zhu

Yale Graduate School of Arts and Sciences Dissertations

Proton-coupled electron transfer (PCET) reactions are essential processes in biological systems, fundamental to various enzymatic functions and redox biology. Key to these reactions are redox-active residues, such as tyrosine and tryptophan, which enhance the efficiency and specificity of electron transfer events. This thesis investigates the thermodynamics, kinetics, and conformational influences of PCET in proteins involving these residues through three projects, each offering significant insights into the mechanisms and broader implications for biological function. The studies have focused on two protein systems: a simple de novo protein system, α3X, and ribonucleotide reductase, an enzyme critical to DNA synthesis. Combining a wide …

Creating Socially Competent Mobile Robots: Rethinking How To Measure Success, Nathan Tsoi

Yale Graduate School of Arts and Sciences Dissertations

Motivated by the value alignment problem, which is concerned with ensuring that an autonomous system's behavior matches user values, this dissertation proposes that creating socially competent mobile robots requires rethinking how success is measured in order to align evaluation metrics with human values and to this end, proposes the use of context-aware simulation systems and subjective human feedback. Social robot navigation is concerned with an agent that must traverse the navigable space in an environment that is shared with people. Conducting such motion in dynamic and densely populated environments demands that a robot understands how humans perceive its behavior and …

A Bioluminescent Approach To Coxiella Burnetii Pathogenesis: Development And Utilization Of An In Vivo Imaging Model, Jenna Myr Andrews

Yale Graduate School of Arts and Sciences Dissertations

Coxiella burnetii is a Gram-negative, obligate intracellular bacterium that infects livestock and causes Q fever in humans, which can range from acute flu-like symptoms to severe, persistent infections. C. burnetii relies on a Dot/Icm type IVB secretion system to translocate effector proteins, manipulating host cell processes to support intracellular replication. While axenic media have facilitated in vitro pathogenesis research, in vivo studies remain limited due to the classification of the virulent Nine Mile phase I strain as a category B select agent. Although the avirulent phase II strain RSA493 is exempt from this classification, it is rapidly cleared in immunocompetent …

Dysregulation Of Transcription And Mrna Processing In Splicing Factor Mutant States: Mechanistic Insights And Implications, Prajwal Chaitanya Boddu

Yale Graduate School of Arts and Sciences Dissertations

Recurrent mutations in RNA splicing factor (SF) genes, such as SF3B1, U2AF1, SRSF2, and ZRSR2, are key drivers of oncogenesis in various cancers, particularly clonal myeloid disorders like Myelodysplastic syndromes (MDS) and Acute Myeloid Leukemia (AML). Over the past decade, significant insights have been gained into their molecular mechanisms and effects on RNA splicing. These mutations are typically heterozygous and non-synonymous (except ZRSR2, which involves single-allele loss-of-function mutations) and are largely mutually exclusive, suggesting shared downstream mechanisms that prevent co-occurrence. Given their pre-eminent roles in splicing, most studies to date have primarily focused on the effects of SF mutations on …

Targeted Deletion Of Cxcl1 In Mscs Regulates Osteogenesis And Suppresses Bone-Metastatic Prostate Cancer, Catherine S. Johnson, Diane L. Costanzo-Garvey, Julio C. Valencia, Sanjana Rajgopal, Theodore Reed, Emma R. Brannon, Jeremy S. Frieling, Deanna Mosley, Todd A. Wyatt, Elijah F. Edmondson, Kabhilan Mohan, Grinu Mathew, Leah M. Cook

Journal Articles: Environmental, Agricultural & Occupational Health

Bone metastasis continues to be the greatest challenge in treating patients with prostate cancer despite ongoing research. In bone, prostate cancer tumors hijack normal bone remodeling processes to drive cancer progression. However, it is unclear how these interactions drive bone-metastatic prostate cancer growth in the bone environment. To understand the mechanisms associated with bone-metastatic prostate cancer regulation of mesenchymal stem cells (MSC), we previously identified that bone-metastatic prostate cancer induces MSC expression of the pro-inflammatory chemokine CXCL8 and its mouse functional homologue Cxcl1. To date, there has been little to no information about the role of CXCL1/8 in MSC biology …

Makers Of Identity: Those That Hold It, Or Those That Create It?, Valentina K. Quintero

SPARK Symposium Presentations

Throughout the semester, the topic of AI potentially achieving personhood has been a deeply debated topic. Issues rise and fall depending on perspective, and there are still too many unknowns to be completely certain that AI has either managed to become a person or has not. One of the key details of personhood is the modern understanding of the word identity. This paper will go into the origins of the word and how it may have changed, and how it is important in regards to AI and its potential. Wittgenstein’s language games, personal opinion, and cultural influences will be explored …

Lawyers’ And Law Professors’ Experience With Worker Governance, Brett H. Mcdonnell

Articles

Part I surveys some of the leading arguments concerning the benefits and costs of worker governance. It also describes some of the ways in which those benefits and costs can evolve along with the growth, or lack thereof, of companies with worker governance. Part II looks at governance in law firms. It considers how the explanations for the adoption of worker governance fare with respect to law firms, notes the limited, elitist nature of worker governance within law firms, and considers the consequences of that real but elitist worker governance for the understanding of lawyers. Part III considers the same …

Corporate Governance For Platform Workers, Matthew T. Bodie, Grant M. Hayden Professor

Articles

Regardless of their status under employment law, we believe that corporate law holds untapped potential in reshaping the rights and working conditions of platform workers. While the law of corporate governance remains aligned with shareholder interests, the collapse of the law-and-economics underpinnings of shareholder primacy should prompt us to develop new approaches to corporate governance. In this Essay, we briefly set out three alternative models for determining whether stakeholders should participate in corporate governance: a democratic participation model, a theory of the firm model, and an information theory model. All are fully consistent with the precepts of standard economics that …

Presidential Control And Administrative Capacity, Nicholas Bednar

Articles

Presidential control is the power to direct administrative capacity toward the President’s own policy objectives. Accordingly, presidential power vis-à-vis administrative policymaking has two necessary components: control and capacity. First, the President must have the ability to set the agency’s policymaking agenda and direct the day-to-day activities of its leadership and career employees. Second, the agency needs a well-managed team of policymakers with expertise and experience in both the substantive policy area and the policymaking process. Yet scholars have long assumed—without much empirical testing—that the administrative state has sufficient capacity to implement the President’s agenda. Not so.

This Article argues that …

Economic History And The Remaking Of Family Law, June R. Carbone, Naomi Cahn

Articles

In looking at the history of family law, we locate family law – and the status of women and children within it – as a function of political economy. That is, family law is shaped by a societal system that allocates access to, and control of, sources of wealth, decision-making power, and responsibility for dependents. As the nature of family assets has changed from land to male wage labor to two incomes and a complex set of complementary employer and state-provided benefits, so too have family dynamics and, ultimately, family law. They have evolved into the contemporary system, with a …

In Memoriam: Robert D. Cooter, Francesco Parisi

Articles

The International Review of Law & Economics is publishing these notes in memory and celebration of Robert D. Cooter—its Editor from 1988 to 2004—offering brief reflections on him as teacher, scholar, and exemplar. A giant of law and economics, Robert D. Cooter combined breadth with creative insight: he helped build a systematic economic understanding of torts, contracts, and property, a novel approach to public law and Constitutional design, and opened new frontiers on the interaction between law and social norms and on the expressive power of law. His humanity and scholarly ethos—curiosity, humor, and intellectual honesty—left a lasting mark on …

Collegiate Nil Collectives: Context, Structure, And Future, Matthew T. Bodie, Esdras D. Camacho

Articles

Since its inception, the NCAA has championed the principle of amateurism in college sports-the idea that collegiate athletes may not receive monetary compensation for their athletic performance. In its 2021 decision in National Collegiate Athletic Association v. Alston, however, the Supreme Court found the NCAA had violated antitrust law with its restrictions on certain benefits provided to athletes. With the possibility of much greater liability to follow, the NCAA soon thereafter enacted a radical departure from past practice, enabling athletes to profit from their names, images, and likenesses ("NIL") while maintaining their amateur status. There were important limitations on this …

Free Speech And Incorporation: A Reassessment, Ilan Wurman

Articles

Many of the Supreme Court’s most controversial free speech decisions involve state laws. In Gitlow v. New York, the Court assumed that the First Amendment’s guarantee of freedom of speech applied directly against the states via the Fourteenth Amendment, a doctrine today referred to as incorporation. Yet there is reason to doubt incorporation is correct as a matter of the original meaning of the Fourteenth Amendment. Indeed, much of the historical evidence involves debates over the freedom of speech, but none of the historical actors seemed to think the First Amendment applied against the states. This short essay evaluates the …

Terror At Home: A 10 Minute Play Exploring History In An Intersectional Method, Starsong Brittain

IdeaFest 2025

This original 10 minute play was inspired by historical research on the early decades of the Soviet Union. Specifically, the "Great Terror" of the 1930s. The play tells experiences of real people but is portrayed as a nature documentary.

The Cycle Of Giving:, Sarai Brown

BYU Asian Studies Student Journal

On one hot summer day in the middle of a 3-month stint studying Mandarin Chinese at National Chung Hsing University (NCHU) in Taichung, Taiwan, my friends and I were desperate to sate our appetites after class, even in the atrociously hot and humid conditions. Most of our little group was drawn to a 牛肉麵 niúròu miàn (beef noodle) shop, but the thought of hot soup on a day like this drove me and a couple of others to continue our search. We stumbled upon another outdoor restaurant—though “restaurant” is perhaps a loose term for the holey-tent-covered food stand with mismatched …

Contributors, Eliana Elkhoury, Jako Olivier, Travis N. Thurston, Morgan Barker, Steven Clontz, Will Cross, Michael Tadeusz Dabrowski, Teresa Focarile, Hillary Fox, Angela George, Sharona Krinsky, Drew Lewis, Erin Mckenney, Lauren Mcmillan, Nalanda Roy, Zoë Soon, James Thibeault, David Tully, Lydia Watson, Sam Winemiller

Open Educational Resources For and As Assessment

No abstract provided.

2. Leveraging Open Pedagogy To Create An Authentic And Renewable Curriculum, Erin Mckenney, Sam Winemiller, Hillary Fox, David Tully, Will Cross

Open Educational Resources For and As Assessment

The high cost of course materials is a barrier for many students, and traditional assessments often fail to inspire engagement. To address these challenges, NC State University Libraries promotes open course materials and open-enabled practices. Since 2014, the Alt-Textbook Project has helped faculty incorporate Open Educational Resources (OER) into their syllabi, reducing textbook costs and supporting innovative educational approaches. This effort was enhanced with the Open Pedagogy Incubator, a multi- semester program bringing together librarians and interdisciplinary faculty to redesign courses around open- pedagogical practices. Dr. McKenney, an incubator participant, redesigned her advanced undergraduate course on Applied Ecology (AEC 400) …

Arcata Hs: Ffa Organization, Leslie Mendoza-Avila

IdeaFest 2025

With my College Corps worksite placement, I was placed in Arcata High School working with 2 AG teachers who are part of a national agricultural program called Future Farmers of America. They have heavy positive influences on the students in the chapter, where many pursue entrepreneurships or higher education opportunities to return home to contribute their knowledge in their former chapter or the Humboldt community. The chapter relies a lot on community support, as its resources are limited. The chapter continues to grow by giving back to the community whether it be helping with floral arrangements at events or even …

Edge Effects On Insects In Coastal Redwoods, Sebastian Mendoza

IdeaFest 2025

When it comes to coastal redwood forests, there aren’t many studies that focus on insect abundance being affected by edge effects. The focus of this study is to see what species of insects are being affected by the forest edge. I will assess this question using pitfalls and sticky traps to trap ground insects and flying insects, respectively. I hypothesize that the closer distance from the edge habitat will positively influence insect diversity. This study will allow future researchers to see if there’s a correlation between insect abundance and other species that use insects as a food source.

Effects Of Human Development On The Spatial And Temporal Behavior On The Neighborhood Mesocarnivore Guild, Amanda Kanaly

IdeaFest 2025

This study researches how urbanization affects the spatial and temporal behavior of mesocarnivore species in the small city of Arcata, California. Specifically, the study tests whether different levels of urban development influence spatio-temporal interactions and the co-occurrence (or lack thereof) of two or more mesocarnivore species, and how habitat characteristics mediate these effects. By analyzing the correlation between habitat features and co-detection events, this research aims to shed light on the dynamics of mesocarnivore coexistence in urban and rural environments, and inform strategies to mitigate the impacts of urbanization on wildlife.

The Gut Microbiome And The Influences On Emotional State, Sophia Hummel, Payton Tausig, Sophia Vanslambrouck, Nathan Aguilar, Angel Roca

IdeaFest 2025

We reviewed current research articles examining the complex relationship between gut microbiome and mood regulation in people. In order to collect our data, we completed a literature review on this topic. We found that there is a very strong relationship between the gut microbiome and mood in people. We observed mental health factors in relationship to mood such as stress, anxiety, and depression. As a result, worsened gut microbiome led to worsened mood factors. This topic has high importance due to how new the topic and research is, and how it affects human health, leading to future implications of treating …

Culvert And Viaduct Features Influencing Mammal Crossing Frequency, Patty Garrett

IdeaFest 2025

An analysis of the biotic and abiotic factors that influence mammal crossing rates through culverts and bridges on a Northern segment of California U.S. Route 101. This study analyzes mammal crossing rates in relation to structure openness, and proximate vegetation density across forty-six remote camera sites.

Reclaiming The Genius Of A Free State, Tennessee's Forgotten Anti-Monopolies Clause, Braden H. Boucek

Belmont Law Review

This article argues that Tennessee’s Anti-Monopolies Clause—enshrined in Article I, Section 22 of the Tennessee Constitution since 1796—has been systematically underenforced and misconstrued by Tennessee courts. Although the constitutional text unequivocally provides that “monopolies are contrary to the genius of a free State and shall not be allowed,” judicial interpretation has diluted this categorical prohibition by importing deferential federal rational basis review and engaging in “lockstepping” with federal substantive due process doctrine. The author contends that this approach is doctrinally unsound because the U.S. Constitution contains no analogous anti-monopoly provision, rendering federal precedent inapposite. Through historical analysis grounded in originalist …

More Than Money: Holistic Outcomes Of Catholic Higher Education, Jason King

Journal of Catholic Education

In an era dominated by financial metrics and return-on-investment rhetoric, this study offers a counternarrative by examining the holistic outcomes of Catholic higher education. Drawing on a nationally representative survey of 2,000 college graduates, it compares alumni of Catholic and secular institutions across three domains: life satisfaction and personal fulfillment; civic engagement and community involvement; and ethical development. The findings reveal that graduates of Catholic colleges report higher life satisfaction, greater civic participation, and a stronger ethical orientation than their secular peers—patterns that persist across demographic subgroups. While Catholic colleges perform well on traditional financial indicators, their distinctive value lies …

The Influence Of Japanese Art And Aesthetics On The Paintings Of Théodore Rousseau, Erinn Alexis Stuart

Graduate Research Theses & Dissertations

Landscape paintings of Barbizon painter Théodore Rousseau provide a unique perspective on the impact of Japanese artworks on nineteenth-century French painting. The examination of Eastern influences on Western art has been confined to Western urban popular culture, resulting in a narrative that restricts the understanding of modern art to the context of Western industrialization. This method of exploring cultural influences constructs a narrative of othering, confining the perception of its impact to the superficial and commercial, thus perpetuating an othering subnarrative, not only between the two nations but also between the different genres of Western art. Through an investigation into …

A Random Walk Simulation Of Positron Annihilation Depth As A Function Of Positron Beam Energy, Saniya Anjum Aqeel Ahmed Yadgeer

Physics Theses - Archive

Depth resolved defect and chemical characterization studies using positron annihilation spectroscopy depend on the ability to estimate the fraction of positrons annihilating at surface, in the bulk, at defects or as Positronium. The depth resolution is limited by the implantation profile of the energetic positrons and the diffusion of the thermalized positrons. Here we implement a random walk simulation as described in S. Eichler et al. [1] to track the monoenergetic positrons implanted into multilayer graphene on Cu. For our simulations the implantation depths were sampled from a Makhovian distribution that has been shown to accurately represent the implantation profile …

The Effects Of Speed, Grade And Footwear On Knee Adduction Moment And Tibial Shock, Alexis C. Gant

Kinesiology Dissertations - Archive

Knee osteoarthritis (OA) is a degenerative joint disease characterized by progressive cartilage deterioration, chronic pain, and reduced mobility. Alterations in gait mechanics, particularly increased knee adduction moment (KAM) and tibial shock, are strongly associated with OA onset and progression. These biomechanical markers reflect abnormal joint loading and provide valuable insights for developing non-invasive interventions. This dissertation investigates how modifiable external factors, specifically walking slope, footwear type, and walking speed, influence knee joint loading patterns. The goal is to inform rehabilitation strategies that can decrease joint stress, alleviate symptoms, and slow disease progression.

Study 1 examines the effects of walking slope …

The Role Of Sodium Butyrate As An Inflammatory Regulator And Its Effect On Long Noncoding Rnas In Neuroinflammation, Angel Covarrubias

Chemistry & Biochemistry Theses - Archive

Inflammation is a crucial homeostatic process that contributes to both the elimination of foreign invaders and tissue repair. Inflammation at sites of tissue injury or infection is initiated by the detection of a harmful stimulus, triggering vital inflammatory immune signaling pathways and a cascade of cytokines and inflammatory mediators. The dysregulation of this process, however, can result in inappropriate inflammatory responses manifesting in tissue damage and compromised cell function. Dysregulation of the inflammatory response is seen frequently in many human diseases such as Diabetes, Cancer, cardiovascular disease, and neurodegenerative diseases.

In the context of the Central Nervous system, inflammation is …

The Evolution Of The Stress Response In The Trinidadian Killifish: Ecological Drivers And Maternal Mediation, Mikaela E. Feder

Biology Dissertations - Archive

Ecological variables can induce the stress response in organisms. Yet, few studies have tested for evolutionary shifts in stress responses across ecological gradients. In these studies, we used Trinidadian killifish found in sites with predators (high predation, HP) and sites where they are the only fish present (killifish only, KO). HP and KO populations differ in a suite of behavioral and life-history traits, making the Trinidadian killifish an excellent model to examine evolutionary physiology. My dissertation addresses the knowledge gap by examining: (1) how baseline cortisol differs in wild-caught Trinidadian killifish found in HP and KO sites, (2) the influence …

Atorvastatin Alters Neuronal Morphology Data Set, Carolyn L. Pytte

Publications and Research

Statins are highly effective and widely prescribed cholesterol lowering drugs. However, statins cross the blood-brain barrier and decrease neural cholesterol in animal models, raising concern that long-term statin use may impact cholesterol-dependent structures and functions in the brain. Cholesterol is a fundamental component of cell membranes and experimentally decreasing membrane cholesterol has been shown to alter cell morphology in vitro. In addition, brain regions that undergo adult neurogenesis rely on local brain cholesterol for the manufacture of new neuronal membranes. Thus neurogenesis may be particularly vulnerable to long-term statin use. Here we asked whether oral statin treatment impacts neurogenesis …