Digital Commons Network^™

Signal Analysis Of Calcium Dynamics In Pancreatic Cells, Abhidha Kunwar

2025 Fall Honors Capstones Projects - Archive

Calcium (Ca²⁺) signaling plays a critical role in insulin secretion from pancreatic βcells. Photo-biomodulation (PBM) of red or near-infrared wavelengths is applied to enhance cellular metabolism and Ca²⁺ activity in pancreatic cells. This study aims to rigorously analyze how PBM influences calcium dynamics in pancreatic cells by applying the Fast Fourier Transform (FFT), converting Ca²⁺ spiking patterns to the frequency domain to determine dominant oscillatory behaviors. Using a calcium-binding fluorophore, Ca²⁺ activity was acquired before and after PBM at 810 nm, processed with a machine learning algorithm, and further analyzed in MATLAB using FFT to assess changes in calcium signal …

Cdh-3/Cadherin, Yap-1/Yap And Egl-44/Tead Promote Syx-2/Syntaxin And Eff-1 Fusogen-Mediated Phagosome Closure, Alec Whited, Aladin Elkhalil, Ginger Clark, Piya Ghose

Biology Theses - Archive

Physical interactions between cells, such as cell-cell junctions, can profoundly impact cell fate. A vital cell fate for normal development and homeostasis is programmed cell death. Cells fated to die must be efficiently cleared away via phagocytosis, and defects are associated with a variety of diseased states. Whether cell-cell physical associations affect programmed cell elimination has not been well-explored. Here we describe, in vivo, a cell-cell adhesion-driven signaling pathway that ensures compartment-specific cell clearance during development. We previously described the specialized cell death program “Compartmentalized Cell Elimination” (CCE) in the C. elegans embryo. During CCE, the tail-spike cell (TSC), a …

The Impact Of Inter-Subunit Communication On F420h2:Nadp+ Oxidioreductase: A Kinetic Approach, Jamariya A. Howard

Chemistry & Biochemistry Dissertations - Archive

F₄₂₀H₂:NADP⁺ Oxidoreductase (Fno) catalyzes the reversible reduction of NADP⁺ to NADPH using reduced F₄₂₀ as the hydride donor. Both NADPH and the F₄₂₀ cofactor play significant roles in various metabolic pathways, including glycolysis and methanogenesis, particularly in methanogenic and sulfate-reducing archaea. These organisms play an essential role in global carbon cycling by converting carbon dioxide to methane through the methanogenic pathway, which is directly tied to energy production. This thesis investigates the hydride transfer mechanism of Fno from the extreme thermophile Archaeoglobus fulgidus, using fluorescence binding, steady-state and pre steady-state kinetics.

Chapter 1 outlines the structural and spectral characteristics …

The Alienated Self: A Solo Exhibtion, Kade Winterton

2025 Fall Honors Capstones Projects - Archive

Exhibiting works is an essential step for every artist; this capstone is a creative research project that explores feelings of alienation and otherness, as well as the multiple causes they stem from, resulting in a body of work ready for exhibition. First, research was conducted on exhibiting and curating works. Next, works by contemporary artists who also explored the same topic were examined. Completed works were curated, and an inventory of what was needed to create an exhibition-ready body of work was defined. After this was done, new works were uniquely created, each starting with an idea and a sketch. …

Impact Of Glufosinate On Soil Microbial Community Dynamics, Sarobi Das

Biology Dissertations - Archive

The increasing global regulations of glyphosate due to its possible carcinogenicity and environmental hazards have necessitated the search for alternative herbicides. Glufosinate-ammonium offers a sustainable attribute due to its low toxicity and limited reported herbicide resistance cases. Despite its increasing agricultural importance, very limited studies are done on its environmental impact, especially on the soil systems. This thesis examines the ecological behavior of glufosinate in soil, precisely focusing on its effect on the dynamics of soil microbiome and the potential use of Bradyrhizobium japonicum USDA110 for bioremediation by reversing the effect of microbial dysbiosis. A series of 30-day mesocosm studies …

How Individual Traits Predict Distribution Patterns And Community Convergence, Zachary K. Lange

Biology Dissertations - Archive

One of the fundamental questions in biology is whether natural conditions lead species and communities toward predictable outcomes. Answering this question requires understanding how traits of individual organisms are connected to species- and community-level patterns. In Chapter 2, I examined how thermal physiology and environmental temperatures interact to determine the distribution patterns of Anolis lizards on the Greater Antilles. I combined lab-measured thermal traits (critical thermal minimum: CT_min, critical thermal maximum: CT_max, thermal preference: T_pref) with occurrence and abundance data from 21 species of Anolis lizards collected from extensive mark-resight surveys of communities across …

Excitation And Polarization Of Isolated Neurons By High-Frequency Sine Waves For Temporal Interference Stimulation, Iurii Semenov, Vitalii Kim, Giedre Silkuniene, Andrei G. Pakhomov

Bioelectrics Publications

The capacity of temporal interference (TI) stimulation to target deep brain regions without affecting nearby surface electrodes remains uncertain. Using artifact-free optical recording, we compare excitation patterns and thresholds in hippocampal neurons stimulated by “pure” and amplitude-modulated sine waves, representing TI waveforms near electrodes and at the target, respectively. We show that pure 2- and 20-kHz sine waves induce repetitive firing at rates that increase up to 60–90 Hz with stronger electric fields. Beyond this limit, action potentials merge into sustained depolarization, resulting in an excitation block. Modulating the sine waves at 20 Hz aligns firing with amplitude “beats” and …

Comparative Life Cycle Assessment Of Conventional Open-Cut Pipeline Replacement With Trenchless Cured-In-Place Pipe Renewal Method For Wastewater Applications Using Midpoint Approach, Eesha Nilesh Karkhanis

Civil Engineering Theses - Archive

Underground infrastructure development has a significant impact on society, leading to continuous technological advancements. With the rising environmental concerns, novel technology is leaning towards adapting to sustainable practices for pipeline rehabilitation. Conducting a comparative study of environmental impacts produced by pipe renewal and replacement processes is a vital step towards sustainable development of underground infrastructure. Open-cut Pipeline Replacement (OCPR) is the conventional method used for pipeline rehabilitation, which involves the excavation of the ground surface to place a new pipe underground or replace an existing one. This process includes the trenching of ground, followed by surface reinstatement through backfill. The …

Assessing Stress, Anxiety, And Burnout In Undergraduate Veterinary Technology Students, Dean Ann Daughaday-Provine

Murray State Theses and Dissertations

Academic stress, anxiety, and burnout can negatively impact the mental health and well-being of students pursuing degrees in veterinary medicine. This quantitative study was designed to investigate the effects of academic stress, anxiety, and burnout on undergraduate students enrolled in Veterinary Technology programs. This study gained critical insight from current students transitioning through a rigorous curriculum of standards designed by the American Veterinary Medical Association (AVMA). The AVMA Committee on Veterinary Technician Education and Activities (CVTEA) has established standards, outlined in policies and procedures, to ensure the quality of assessments and enhancements in veterinary education within accredited Veterinary Technology programs.

Exploring A Collective Grief Experience In The U.S.: Qualitative Findings From Older Parents Whose Only Child Has Died, Yongqiang Zheng, Leslie Wuest, Jeongah Kim, Rebecca Rodriguez

Faculty Publications - College of Social Work

Despite its profound physical and mental health impacts, research on the loss of an only child in later life among older U.S. adults remains scarce. This phenomenological qualitative study explores the lived experiences and meanings older bereaved parents attribute to their loss. Data from 24 participants were collected through written narratives guided by structured questions, and online focus groups. Inductive thematic analysis revealed 6 themes: the enduring intensity of grief, significant secondary losses, feelings of isolation and alienation, the role of social support in coping, and spirituality and religion’s influence on their journey. By amplifying these parents’ voices, the study …

Denile On The Nile: Balancing Ethiopia's Equitable And Reasonable Utilization Of The Nile And Egypt's Desire To Maintain The Status Quo, Tyler Tipton

Case Western Reserve Journal of International Law

For nearly one hundred years, Egypt has maintained complete control and utilization of the Nile River under the 1929 Nile Agreement signed by Egypt and the United Kingdom. This agreement was amended in 1959, making Sudan a party but alienating the remaining Nile Basin States. Ethiopia has now posed the greatest challenge to the validity of these Agreements by constructing the Grand Ethiopian Renaissance Dam. This Note argues that the longstanding bilateral 1929 and 1959 Nile Agreements can no longer maintain their enforceability against the rest of the Nile Basin because they violate customary international water law and infringe on …

Abundance And Other Food Fixations, Margot J. Pollans

Elisabeth Haub School of Law Faculty Publications

Although most people in the United States no longer devote the majority of their time to food production, processing, and distribution, food remains a daily fixation. This Article explores three driving food fixations--abundance, thinness, and health--and situates each against an inverse fear--scarcity, fatness, and illness, respectively. Mapping these threats onto U.S. food policy, this Article examines, among other policy arenas, food waste policy, nutrition and health claim labeling law, and food additive regulations. Across food policy, these fixations feed what this Article calls the “politics of abundance.” This politics helps to insulate the food industry from deeper systemic reform aimed …

Vol. 28, No. 1: Full Issue, Water Law Review

Water Law Review

No abstract provided.

Regionality In Heart Failure Self-Care Behaviors Using The Medical Expenditure Panel Survey, Gretchen K. Wendt

Nursing Dissertations - Archive

Heart failure (HF) risks increase as patients age, with most of the HF patients having at least one chronic condition and 40% having two or more. Further confounding the HF morbidity and chronic medical conditions are psychiatric conditions like depression and anxiety. For most Americans with HF, managing the diagnosis and chronic conditions can be overwhelming. To formalize the definitions of HF disease management, the concepts of self-care from the situation-specific theory of HF self-care (SST-HFSC) were applied.

The medical complexity of HF self-care during the pandemic was shown to vary based on the US region where the individual resided. …

Field Trials Report 2024: Wa Farming Systems Project (Daw2204-003rtx), Department Of Primary Industries And Regional Development, Western Australia

Farm Systems and Economics research reports

Within the Western Australian Faming Systems Project, a program of 11 field trials were conducted in 2024 from Ogilvie in the north to Wittenoom Hills in the south.

The season was a challenging one with a late break to the season at all sites and varying conditions from decile 3 to decile 10 growing season rainfall across the sites.

Iactor: Integrating Flow Theory And Habit Principles To Combat Decision Fatigue In Audition Management, Colby L. Bell

Graduate Thesis and Dissertation post-2024

For many actors, the audition process can feel like a never-ending series of decisions—what to prepare, what to wear, what to bring, and how to keep track of it all. Each choice, though seemingly small, accumulates into a form of cognitive overload that can lead to burnout and disengagement. My fascination lies not only with how actors navigate this process but how we might reframe it. This thesis explores the question: How can I design a digital space that reduces decision fatigue and restores agency to actors preparing for auditions? Drawing from Mihaly Csikszentmihalyi’s Flow Theory, James Clear’s Atomic Habits …

Journeys Across Worlds, Carolina Guzman

Graduate Thesis and Dissertation post-2024

Journeys across Worlds is a collection of five short stories that transport readers into otherworldly landscapes. Each narrator embarks on a transformative journey, encountering adventure, wonder, and self-discovery. In “Through Borrowed Eyes,” a blind sorceress wields a powerful curse to see through the eyes of others, only to realize the cost of her magic may be too great. “A Gaze Across Dreams” follows a lonely Dreamweaver who, after an eternity of being unseen, is suddenly perceived by a lucid dreamer. The collection concludes with “Where the Skies Are Blue,” a tale of two sisters navigating a post-apocalyptic world, where the …

The Unindexed Marginalia Of Historical American Cookery Books Digital Public History Project: Domestic Technical Communication Labor Contributions, Alessandra Zinicola Lopez

Graduate Thesis and Dissertation post-2024

This dissertation includes a traditional written portion, and a non-traditional digital humanities public history online digital archive project created through Omeka which showcases examples of hand-written recipes found within commercial cookbooks, called marginalia. The understanding of modern technical communication is affected by the perceived history of the field and currently, that history is biased toward non-domestic pursuits. The project explores what collecting, digitizing, and archiving examples of historical hand-written marginalia found within commercially printed American receipt books indicate about the presence, participatory nature, value, and contributions of domestic technical communications and their user-authors in the 19th century. The examples collected …

Examination Of Users’ Privacy Issues In Live Streaming Information Disclosure, Yanlai Wu

Graduate Thesis and Dissertation post-2024

Live streaming has gained global popularity, raising significant privacy concerns due to its performance-driven, real-time, on-camera, and public nature. Increasing reports highlight privacy violations in live streaming, including streamers facing harassment from malicious viewers and bystanders being inadvertently exposed to audiences. Despite these challenges, research on privacy in live streaming remains limited. This dissertation addresses this gap by examining users' privacy concerns and strategies in information disclosure and exploring design solutions to enhance privacy management on live streaming platforms.

To achieve these objectives, I conducted three qualitative studies: two interview studies (Study 1: Chapter 4 and Study 2: Chapter 5) …

The Impact Of Visualization Styles On Movement Imitation Accuracy In Virtual Reality, Gabriela R. Shamblin

Graduate Thesis and Dissertation post-2024

Virtual reality (VR) has become a powerful tool for motor learning and skill acquisition, offering immersive environments for users to practice and refine movements. This thesis investigates how different visualization styles in VR affect movement imitation accuracy, specifically focusing on hand movements. While prior research has explored precise alignment and visualization individually, few studies have examined their combined impact. This study addresses that gap by evaluating the effectiveness of various visualization methods in relation to offset, animation, and manual type.

We developed an application to ensure all participants experienced each visualization factor as 12 combinations in varied sequences. The user …

Removal Of Long- And Short-Chain Per- And Polyfluoroalkyl Substances From Surface Water Using Green Sorption Media–Nanofiltration Hybrid Processes, Md Touhidul Islam

Graduate Thesis and Dissertation post-2024

Per- and polyfluoroalkyl substances (PFAS) are a class of persistent environmental contaminants that pose significant risks to human health and aquatic ecosystems. This dissertation addresses the removal of both long- and short-chain PFAS from surface water through an integrated approach that combines green sorption media (GSM) with nanofiltration (NF). The research comprises laboratory-scale and field-scale studies designed to evaluate the effectiveness of novel recycled-material-based GSM formulations—namely, CPS and ZIPGEM—as pretreatment options to mitigate membrane fouling and enhance PFAS removal during NF. The study also investigates the adsorption mechanisms under varying water chemistry conditions, including pH, ammonia, and divalent cation concentrations. …

Examining Information Flows Within Transformer Models Using Transfer Entropy, Clayton Barham

Graduate Thesis and Dissertation post-2024

The rapid growth of artificial intelligence, in terms of both power and prevalence, motivates the need for new ways to study explainability in deep neural networks. This is especially true for transformer architectures and large language models, which are the driving force behind the current surge in artificial intelligence. The complexity of transformer architecture foils many pre-existing methods for studying explainability in deep neural networks. To address this gap in knowledge, this dissertation proposes a new method of studying explainability in transformer architectures that leverages insights from neuroscience, employing transfer entropy to map information flows between components of the transformer …

Insights Into Iapodian Lifeways: Phytolith And Starch Grain Analysis Of Animal And Human Dental Calculus From Croatia, Angelinne Moreno

Graduate Thesis and Dissertation post-2024

The Piplica hillfort is located near the village of Lovinac within the Lika region of Croatia. The Bronze Age is a pivotal period in Europe that encompasses changes in landscapes, social structures, and famously includes vast production of metals. The Bronze Age in Lika is characterized by changes in social, political, and economic lifeways; denser populations; expanded trade networks; and advancements in agriculture, husbandry, and metal-working. However, little is known about the Iapodes people, who inhabited the Lika region during the Late Bronze Age, and how they interacted with their environment.

The Iapodes were only known from classical Greek written …

Enhancing Social Participation: The Role Of Communication Accommodations On Young Children With Ccn, Carli C. Brent

Graduate Thesis and Dissertation post-2024

BACKGROUND: Children with complex communication needs (CCN) have difficulty using and/or understanding speech to communicate, thus facing barriers for successful social participation in family-leisure activities due to limited access to communication supports in these environments. Social participation includes an individual’s active involvement in activities that consist of a social element to produce opportunities for meaningful interactions with others. Children with CCN benefit from communication supports, like Augmentative and Alternative Communication (AAC) devices. AAC supports children with CCN to effectively communicate with themselves, others, and their environment. While communication supports have been recently implemented into private and public spaces, the …

Boba Tea Shops And Identity: Exploration Of Boba Shops Among College Students In Greater Orlando, Naydelin Karime Trejo Vega

Graduate Thesis and Dissertation post-2024

This thesis explores the cultural and social significance of boba tea shops among college students aged 18 to 26 in Greater Orlando. Although many people view boba tea as a trendy drink, this study treats it as a meaningful part of some students’ daily lives, identity formation, and sense of belonging. Through a multi-method approach that includes participant observation, surveys, and semi-structured interviews, I examine what motivates college students to purchase boba tea and how boba shops impact their identity and sense of belonging. I conducted fieldwork at three different boba tea shops in Greater Orlando—two franchises and one locally …

Lowering The Barrier For Reading Primary Literature In Stem, Sebastian G. Alvarado, Maral Tajerian

Open Educational Resources

Building Bridges of Knowledge (BBK) is a cross‑CUNY initiative that integrates artificial intelligence (AI) and open educational resources to lower the barrier to primary literature and enhance research‑focused pedagogy. Recognizing that scientific papers are often dense and inaccessible to newcomers, we developed a suite of AI‑assisted instructional materials and activities to help students interpret complex data and methodology. A central component is the use of large language models (LLMs) and tools such as Scite.ai to provide citation‑context analytics and personalized research support. These tools allow students to filter literature by supportive, neutral, or contrasting citation statements and to troubleshoot laboratory …

Distribution And Morphology Of Spinal Afferent Innervation Of The Gastric Muscular And Submucosal Layers Of Rats: Anterograde Tracing, Andrew M. Kwiat

Graduate Thesis and Dissertation post-2024

Chronic pain afflicts over 25 million Americans, with approximately 2 million developing opioid addiction due to insufficient treatment options. Visceral chronic pain, particularly abdominal pain, poses a significant clinical challenge, yet its underlying neural mechanisms remain poorly defined. This thesis presents a comprehensive anatomical analysis of spinal afferent innervation in the muscularis externa and submucosal layers of the rat stomach—two tissue compartments implicated in visceral sensation and pain. Using anterograde tracing, dextran-biotin was injected into thoracic dorsal root ganglia (T7–T11) of male Sprague Dawley rats (3–5 months) to label spinal afferent axons in the stomach. Flat-mount preparations of muscular and …

Targeting Il-6 Signaling And Release Pathways Modulates Inflammation And Restores Intestinal Epithelial Integrity And Function During Mycobacterium Avium Paratuberculosis Infection, Ala' Mahmoud Saleem Alhendi

Graduate Thesis and Dissertation post-2024

Like TNFα, IL-6 is upregulated in Crohn’s disease (CD) associated with Mycobacterium avium paratuberculosis (MAP) infection. Limited therapeutic response to anti-IL-6 therapy may be related to the dual role of IL-6. In this study, we investigated the effects and the signaling mechanism of IL-6 in intestinal epithelial integrity and function during MAP infection using an in vitro model that consists of THP-1, HT-29 and Caco-2 cell lines. Clinically, we determined that plasma samples from MAP-infected CD patients have higher IL-6 levels compared to controls (P-value < 0.001). In CD-like macrophages, MAP infection has significantly upregulated the secretion of IL-6 and the shedding of IL-6 receptor (IL-6R). Moreover, it resulted in significant upregulation of intestinal damage markers including CLDN2, NOX-1 and SERPINE1. Blocking IL-6 signaling exacerbated that damage and enhanced the levels of the damage markers. In HT-29 cells, MAP infection upregulated MUC2 expression, a protective response that was reversed when IL-6R was neutralized. More importantly, blocking IL-6 signaling during MAP infection rescued damaged Caco-2 cells from MAP-induced apoptosis. We also examined the role of monocarboxylate transporter 4 (MCT4), a proton-coupled lactate symporter, that facilitates the inflammatory shift in macrophages, and its impact on intestinal epithelial homeostasis during MAP infection. MAP infection increased lactate export and upregulated the expression of MCT4, TNFα, and IL-6 via TLR2. Inhibition of MCT4 during MAP infection using α-cyano-4-hydroxycinnamic acid (CHCα) significantly reduced TNFα and IL-6 and led to restoring baseline oxidative status, mucin level, and SERPINE1. It also enhanced tight junction protein TJP1 (ZO-1) expression. These findings emphasize the role of IL-6 in MAP-associated CD pathogenesis and explain the ineffective response to IL-6 therapies in CD patients. Moreover, our findings revealed the role of MCT4 in CD pathophysiology during MAP infection and highlighted MCT4 as a potential therapeutic target for effective CD treatment.

You And Me: Imagination As A Coping Mechanism For Childhood Trauma, Rachel B. Sacks

Graduate Thesis and Dissertation post-2024

You and Me is a two-dimensional (2D) animated short film about a young girl who suffers from an unknown illness. As she tries to rest, two otherworldly monsters transform her room into an unsettling nightmare. These monsters stem from her own distorted perceptions of the doctor and nurse caring for her. You and Me focuses on the difficulties that children navigating medical challenges face in communicating their fears with their caretakers. It is a film rooted staunchly in the subjective world of its protagonist. The art style deliberately combines conventionally appealing character design with surrealist imagery and evocative, unsettling lighting …

Gothic Girlhood Horrors, Nina M. Lopez

Graduate Thesis and Dissertation post-2024

Gothic Girlhood Horrors is a collection of creative nonfiction examining the formative experiences of girlhood. Through experimental essays, short stories, and other forms of prose, it investigates how universal and personal a young woman’s experiences can be. Part I, “HOW TO BECOME A GIRL,” opens with a coming-of-age story. “GIRL CRAZY” takes inspiration from memoirist Elissa Washuta’s “Sexually Based Offenses,” with the narrator engaging in a hypothetical conversation. Some essays explore the narrator’s relationship with motherhood; others delve into the complex relationship with her own mother. Key moments of girlhood are highlighted, such as dying hair (“let down your hair”) …