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Curriculum Subcommittee Agenda January 02, 2025, Utah State University

Educational Policies Committee

• Approval of Minutes
• Program Proposals
• Semester Course Approval Reviews
• Other Business
• Adjourn

Pivotal Roles Of Biglycan And Decorin In Regulating Bone Mass, Water Retention, And Bone Toughness, Rui Hua, Yan Han, Qingwen Ni, Roberto J. Fajardo, Renato V. Iozzo, Rafay Ahmed, Jeffry S. Nyman, Xiaodu Wang, Jean X. Jiang

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Proteoglycans, key components of non-collagenous proteins in the bone matrix, attract water through their negatively charged glycosaminoglycan chains. Among these proteoglycans, biglycan (Bgn) and decorin (Dcn) are major subtypes, yet their distinct roles in bone remain largely elusive. In this study, we utilized single knockout (KO) mouse models and successfully generated double KO (dKO) models despite challenges with low yield. Bgn deficiency, but not Dcn deficiency, decreased trabecular bone mass, with more pronounced bone loss in dKO mice. Low-field nuclear magnetic resonance measurements showed a marked decrease in bound water among all KO groups, especially in Bgn KO and dKO …

The Effects Of Active Substances Of Clinically Important Drugs On The Survival, Development, And Some Adult Traits Of Drosophila Melanogaster Meigen (Diptera: Drosophilidae), Gökçe Üstündağ, Kemal Büyükgüzel, Ender Büyükgüzel

Turkish Journal of Zoology

Drosophila melanogaster Meigen (Diptera: Drosophilidae) was used as a model organism and fed on an artificial diet with different clinically important drugs under laboratory conditions. The effects of fluconazole, acyclovir, and piperazine on the survivorship, development, adult longevity, fecundity, and hatching rate of the insect were investigated. The results showed that the highest concentration of fluconazole (1250 mg/L) significantly decreased both the rate of larvae reaching the 3rd instar and the rate of pupation from 93.00 ± 2.95% to 11.00 ± 2.59% (χ2 = 134.696; df = 1; p = 0.0001). The highest concentration of acyclovir (200 mg/L) significantly reduced …

Enhanced Motivated Behavior Mediated By Pharmacological Targeting Of The Fgf14/Nav16 Complex In Nucleus Accumbens Neurons, Nolan M Dvorak, Paul A Wadsworth, Guillermo Aquino-Miranda, Pingyuan Wang, Douglas S Engelke, Jingheng Zhou, Nghi Nguyen, Aditya K Singh, Giuseppe Aceto, Zahra Haghighijoo, Isabella I Smith, Nana Goode, Mingxiang Zhou, Yosef Avchalumov, Evan P Troendle, Cynthia M Tapia, Haiying Chen, Reid T Powell, Timothy J Baumgartner, Jully Singh, Leandra Koff, Jessica Di Re, Ann E Wadsworth, Mate Marosi, Marc R Azar, Kristina Elias, Paul Lehmann, Yorkiris M Mármol Contreras, Poonam Shah, Hector Gutierrez, Thomas A Green, Martin B Ulmschneider, Marcello D'Ascenzo, Clifford Stephan, Guohong Cui, Fabricio H Do Monte, Jia Zhou, Fernanda Laezza

Faculty, Staff and Student Publications

Protein/protein interactions (PPI) play crucial roles in neuronal functions. Yet, their potential as drug targets for brain disorders remains underexplored. The fibroblast growth factor 14 (FGF14)/voltage-gated Na+ channel 1.6 (Nav1.6) complex regulates excitability of medium spiny neurons (MSN) of the nucleus accumbens (NAc), a central hub of reward circuitry that controls motivated behaviors. Here, we identified compound 1028 (IUPAC: ethyl 3-(2-(3-(hydroxymethyl)-1H-indol-1-yl)acetamido)benzoate), a brain-permeable small molecule that targets FGF14R117, a critical residue located within a druggable pocket at the FGF14/Nav1.6 PPI interface. We found that 1028 modulates FGF14/Nav1.6 complex assembly and depolarizes the voltage-dependence of Nav1.6 channel inactivation with …

Nucleus-Translocated Gclm Promotes Chemoresistance In Colorectal Cancer Through A Moonlighting Function, Jin-Fei Lin, Ze-Xian Liu, Dong-Liang Chen, Ren-Ze Huang, Fen Cao, Kai Yu, Ting Li, Hai-Yu Mo, Hui Sheng, Zhi-Bing Liang, Kun Liao, Yi Han, Shan-Shan Li, Zhao-Lei Zeng, Song Gao, Huai-Qiang Ju, Rui-Hua Xu

Faculty, Staff and Student Publications

Metabolic enzymes perform moonlighting functions during tumor progression, including the modulation of chemoresistance. However, the underlying mechanisms of these functions remain elusive. Here, utilizing a metabolic clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 knockout library screen, we observe that the loss of glutamate-cysteine ligase modifier subunit (GCLM), a rate-limiting enzyme in glutathione biosynthesis, noticeably increases the sensitivity of colorectal cancer (CRC) cells to platinum-based chemotherapy. Mechanistically, we unveil a noncanonical mechanism through which nuclear GCLM competitively interacts with NF-kappa-B (NF-κB)-repressing factor (NKRF), to promote NF-κB activity and facilitate chemoresistance. In response to platinum drug treatment, GCLM is phosphorylated by P38 …

Differentiation Of Mullus Barbatus And Mullus Surmuletus (Perciformes, Mullidae) From Turkish Waters Of The Mediterranean Sea Using Otolith Shape Analyses, Semra Saygin

Turkish Journal of Zoology

Red mullet (Mullus barbatus) and surmullet (Mullus surmuletus) are valuable components of the commercial fishery industry in the Mediterranean Sea in Türkiye. To date, morphological and genetic characteristics have been used to distinguish these species. This study aimed to determine whether it was possible to distinguish between the two species using the morphometric features of their sagittal otoliths. Sagittal otoliths were subjected to elliptic Fourier analysis, wavelet analysis, and analysis of otolith shape indices for 117 specimens from the Mediterranean Sea coast of Türkiye (Mullus barbatus: 53 individuals; Mullus surmuletus: 64 individuals). Overall, canonical discriminant analysis (CDA) demonstrated strong discrimination …

Cover And Contents

Turkish Journal of Zoology

No abstract provided.

Atrx Silences Cartpt Expression In Osteoblastic Cells During Skeletal Development, Yi-Ting Chen, Ming-Ming Jiang, Carolina Leynes, Mary Adeyeye, Camilla F Majano, Barakat Ibrahim, Urszula Polak, George Hung, Zixue Jin, Denise G Lanza, Lan Liao, Brian Dawson, Yuqing Chen-Evenson, Oscar E Ruiz, Richard J Gibbons, Jason D Heaney, Yangjin Bae, Brendan Lee

Faculty, Staff and Students Publications

ATP-dependent chromatin remodeling protein ATRX is an essential regulator involved in maintenance of DNA structure and chromatin state and regulation of gene expression during development. ATRX was originally identified as the monogenic cause of X-linked α-thalassemia mental retardation (ATR-X) syndrome. Affected individuals display a variety of developmental abnormalities and skeletal deformities. Studies from others investigated the role of ATRX in skeletal development by tissue-specific Atrx knockout. However, the impact of ATRX during early skeletal development has not been examined. Using preosteoblast-specific Atrx conditional knockout mice, we observed increased trabecular bone mass and decreased osteoclast number in bone. In vitro coculture …

Differential Microbial Community Assembly Following Co-Housing Versus Microbiota Transplant, James S Weagley, Luis Alberto Chica Cárdenas, Ana Romani, Meagan E Sullender, Somya Aggarwal, Heyde Makimaa, Michael P Hogarty, Rachel Rodgers, Elizabeth A Kennedy, Lynne Foster, Lawrence A Schriefer, Megan T Baldridge

2020-Current year OA Pubs

Mouse models are vital tools for discerning the relative contributions of host and microbial genetics to disease, often requiring the transfer of microbiota between different mouse strains. Transfer methods include antibiotic treatment of recipients and colonization using either co-housing with donors or the transplantation of faecal or caecal donor material. However, the efficiency and dynamics of these methods in reconstituting recipients with donor microbes is not well understood. We thus directly compared co-housing, faecal transplantation, and caecal transplantation methods. Donor mice from Taconic Biosciences, possessing distinct microbial communities, served as the microbial source for recipient mice from Jackson Laboratories, which …

N-Linked Fucosylated Glycans Are Biomarkers For Prostate Cancer With A Neuroendocrine And Metastatic Phenotype, Joseph E Ippolito, Hani Nakhoul, Cody Weimholt, Elena Nunez, Nikolaos A Trikalinos, Et Al.

2020-Current year OA Pubs

Prostate cancer is a heterogeneous disease with a spectrum of pathology and outcomes ranging from indolent to lethal. Although there have been recent advancements in prognostic tissue biomarkers, limitations still exist. We leveraged matrix-assisted laser desorption/ionization imaging of formalin-fixed, paraffin embedded prostate cancer specimens to determine if N-linked glycans expressed in the extracellular matrix of lethal neuroendocrine prostate cancer were also expressed in conventional prostate adenocarcinomas that were associated with poor outcomes. We found that N-glycan fucosylation was abundant in neuroendocrine prostate cancer as well as adenocarcinomas at the time of prostatectomy that eventually developed recurrent metastatic disease. Analysis of …

Two-Hit Mouse Model Of Heart Failure With Preserved Ejection Fraction Combining Diet-Induced Obesity And Renin-Mediated Hypertension, Justin H Berger, Xian Chen, Attila Kovacs, Et Al.

2020-Current year OA Pubs

Heart failure with preserved ejection fraction (HFpEF) is increasingly common but its pathogenesis is poorly understood. The ability to assess genetic and pharmacologic interventions is hampered by the lack of robust preclinical mouse models of HFpEF. We developed a novel "two-hit" model, which combines obesity and insulin resistance with chronic pressure overload to recapitulate clinical features of HFpEF. C57Bl6/NJ mice fed a high-fat diet (HFD) for > 10 weeks were administered an AAV8-driven vector resulting in constitutive overexpression of mouse Renin1d. HFD-Renin (aka "HFpEF") mice demonstrated obesity and insulin resistance, moderate left ventricular hypertrophy, preserved systolic function, and diastolic dysfunction indicated …

T Helper 2 Cell-Directed Immunotherapy Eliminates Precancerous Skin Lesions, Tomonori Oka, Neel S. Raval, Mary Tabacchi, Lynn A. Cornelius, Et Al.

2020-Current year OA Pubs

The continuous rise in skin cancer incidence highlights an imperative for improved skin cancer prevention. Topical calcipotriol-plus-5-fluorouracil (calcipotriol-plus-5-FU) immunotherapy effectively eliminates precancerous skin lesions and prevents squamous cell carcinoma (SCC) in patients. However, its mechanism of action remains unclear. Herein, we demonstrate that calcipotriol-plus-5-FU immunotherapy induces T helper type 2 (Th2) immunity, eliminating premalignant keratinocytes in humans. CD4+ Th2 cells were required and were sufficient downstream of thymic stromal lymphopoietin cytokine induction by calcipotriol to suppress skin cancer development. Th2-associated cytokines induced IL-24 expression in cancer cells, resulting in toxic autophagy and anoikis followed by apoptosis. Calcipotriol-plus-5-FU immunotherapy was dependent …

Spatiotemporal Variation Of Vegetation Cover In Mining Areas Of Ysr Kadapa District, Andhra Pradesh Using Remote Sensing And Gis, Vinod Kumar Yarlanki, Prudhvi Raj Muppala, Prem Kumar Yasam, Balaji Gollapudi, Sumanth Moddu, Appanna Besta

Journal of Sustainable Mining

The spatiotemporal variation of vegetation cover in the mining areas of YSR Kadapa district, Andhra Pradesh, using Remote Sensing and GIS techniques. By focusing on the years 2014, 2018, and 2023, the analysis provides insights into changes observed in water bodies, bare soil, sparse vegetation, moderate vegetation, and dense vegetation. The results reveal dynamic trends in land cover categories, highlighting the environmental impact of mining activities in the region. A significant decline in water bodies is observed, with the area reducing from 3.48 km² in 2014 to 1.91km² in 2023. This decrease raises concerns about the potential degradation …

Ensnared By Custom: Mary Astell And The American Bar Association On Female Autonomy, Judy Cornett

Book Chapters

Rhetoric—the arts of practical discourse that we broadly define as the use of symbols to influence belief and action—has something to say about contemporary legal theory and practice. Law and rhetoric in the West were born together nearly 2500 years ago in the Mediterranean. American law has eschewed its rhetorical roots since the late nineteenth century. Denying law’s rhetorical nature helps to construct an impartial façade, shoring up law’s legitimacy. Admitting the rhetorical nature of law would be to admit its partiality, or the point of view inevitably inscribed with every textual choice. At the same time, rhetorical theorists have …

Lessons In Low-Tech: A Handbook For Sustainable Education, Ceri Almrott, Loann Astorino, Sébastien Bette, Benoit Delinchant, Philippe Fortemps, Ulysse Girard, Paul Hendrick, Sacha Hodencq, Fabian Lecron, Julie Lhuissier, Kévin Loesle, Luis Miguel Lopez Santiago, Santiago Perez Rodriguez, Gauthier Renard, Tatiana Reyes, Virginie Vandenbulcke, John Walsh

Other resources

LT4SUSTAIN, an Erasmus+ funded transnational project, is at the forefront of responding to the increasing awareness of environmental and climate challenges. This awareness, particularly among youth, has led to a demand for social justice. With the coordinated work among six institutions, ranging from higher education institutions to private companies and associations, LT4SUSTAIN aims to raise awareness of Lowtech across society.

LT4SUSTAIN is pioneering a unique approach to technology design. By developing “hackathons” and other “hands-on” events, we are engaging students and industry in a way that improves inclusiveness. Our objective is to equip individuals with the skills to embark on …

Lusaka's Colonial Legacy: Town Planning, Public Health, And The Making Of A Segregated City, 1913–1963. A Study Of Power, Inequality, And Urban Development, Wamburakwao J. Sapao

Zambia Social Science Journal

This paper explores the intersection of town planning and public health policy in Lusaka, Northern Rhodesia (now Zambia), during the colonial period (1913–1963), which was a time of significant urban growth and transformation. British colonial authorities adapted Ebenezer Howard's Garden City principles to design and manage Lusaka, but these measures perpetuated spatial control, segregation, and social engineering, thus exacerbating racial and socio-economic disparities. By analysing secondary and primary sources, including planning ordinances, zoning regulations, and public health policies, this study reveals how these measures shaped the city's development and reinforced inequalities. Despite colonial intentions for a white settler-city, Lusaka evolved …

How Assistance Dogs Impact The Academic And Social/Emotional Development Of Students With Disabilities, Elizabeth A. Bloom

All Electronic Theses and Dissertations

This literature review explores the impact of using assistance dogs in special education to address social-emotional development and academic success for students with various disabilities. The review evaluated dog-assisted interventions, a form of animal-assisted therapy, increasingly used in schools, libraries, hospitals, and higher education settings. The research findings reported positive outcomes when animals were used, such as increased motivation, reduced anxiety, and improved reading skills (Bassette and Taber- Doughty (2013), Goodmon et al. (2021), Herderson et al. (2020). More rigorous, long-term research across diverse student populations and disability categories is needed to address the long-term benefits of animal- assisted therapy. …

Impact Of Nature-Based Tourism On Bird Vocalization Rate In The Bajo Del Tigre Reserve, Monteverde, Costa Rica, Abby K. Bressette, Adriana Arias Aguilar

Environmental Studies Publications

Nature-based tourism benefits economies, communities, and conservation initiatives, but it can also have unintended negative effects on wildlife. For birds, vocal communication is essential, yet it can be disrupted by anthropogenic noise. In this study, I used passive recording to examine how human visitation impacts the rate of bird vocalizations in the Bajo del Tigre Reserve in Monteverde, Costa Rica. Overall, bird vocalization rate was not affected by visitation (p > 0.05), but species-specific differences were found. Vocalizations of the lesser greenlet showed no significant change with visitation (p > 0.05). In contrast, the orange-billed nightingale-thrush exhibited a decrease in vocalization rates …

Course Catalog 2025-2026, Csusb

CSUSB Course Catalog

No abstract provided.

Quiet As Maus - Are Obscenity Laws Directed At School Libraries Silencing Children's First Amendment Protections?, Gabrielle Mark-Bachoua

California Western Law Review

No abstract provided.

The Health Impact Of Clinical Training On Nursing Students In Cambodia, Felicia Kim Yee, Kimberly Aguilar Mondragon

Nursing | Senior Theses

Background: Clinical training presents significant challenges for nursing students worldwide, particularly evident in developing countries like Cambodia, where these difficulties are intensified by a lack of training, resources, and health issues like stress and fatigue. Many students struggle without adequate guidance, forcing them to navigate complex clinical environments independently. These factors not only impact students’ confidence and academic performance, but also their health and well-being. Through this study, we can gain insight into nursing in a developing country that hasn’t been widely studied, contributing to global nursing research. Purpose: The purpose of this study is to explore the health impact …

West Central Minnesota Regional Food Assessment, Ed Brands, Daniel Jahngurske, Allison Koos, Kat Kraemer, Argie Manolis, Mikayla Morris, Isabel Olson, Cristina Ortiz, Annabelle Scafe

Center for Small Towns

This project documents food access, barriers, production, and suggestions for improvement in the food system across a largely agricultural five-county (Douglas, Grant, Pope, Stevens, and Traverse) region in West-Central Minnesota. A variety of methods, including surveys, interviews, and focus groups, were used to gather data. Secondary (e.g., US Census, USDA Census of Agriculture) and historical (e.g., grocery store directories) data were also used in this project.

Approximately half of household food security survey respondents (N= 283) had in the last year at least worried about there not being enough money for food in their household. Respondents experiencing food insecurity were …

Cc Magazine Winter 2025, Connecticut College

Alumni News/Connecticut College Magazine

No abstract provided.

2025 Welcome To Soar, Morehead State University. Office Of Communications & Marketing.

Communications and Marketing Publications Archive

The 2025 Morehead State University SOAR Guide Pack.

On The Incarnation: The Good News Of Jesus For The Renewal Of The World, Athanasius Of Alexandria, Jeremy Treat

Sacred Roots Spiritual Classics

No abstract provided.

Pediatric Approaches For Magnetic Resonance Imaging, Ashley Riha

Student Research Poster Presentations 2025

Abstract

Pediatric magnetic resonance imaging is often challenging due to the lack of cooperation and the inability to fully understand the expectations required for the examination. Children are often restless and may have difficulty remaining still for a long period of time. This can lead to motion artifacts and compensate diagnostic value. Due to these reoccurring challenges, there are several strategies to help relax the nerves of pediatric patients. Sedatives can be administered to relax the patients and assist in cooperation during the long scanning times. However, sedation safety, dosage, and patient monitoring is essential when administering medication. Alternative approaches …

Town Of Greenville, New Hampshire 2024 Annual Report, Greenville Town Representatives

Greenville, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Laboratory Exercises For Biol 1011 (Biology For Non-Majors Laboratory), Larry Bowman Baranowski

Open Educational Resources

Laboratory Exercises for BIOL 1011 (Biology for Non-majors Laboratory) provides three laboratory exercises: Climate Change Lab, Species Extinction Lab, and Genetically Modified Organisms Lab.

Captive Collared-Doves ( Streptopelia Spp.) Like Millet, But Prefer Corn, Daniel Francois

IdeaFest 2025

The Eurasian collared-dove (Streptopelia decaocto) is an invasive columbiform that has spread across the continent of North America in under thirty years since its first introduction (Smith 1987, Romagosa and McEneaney 1999). Since then, it has competed with and dominated a variety of native passerines (Romagosa and McEneaney 1999, Romagosa and Labisky 2000). Our goal was to further discover its feeding habits and dietary preferences in order to gain a better understanding of its impact on native birds such as the mourning dove (Zenaida macroura). We hypothesized that collared-doves would prefer corn over millet seeds, and millet seeds over oats …

Evaluating Samsung Smarttags As A Low-Cost Wildlife Tracking Tool, Daniel Meng, Rick Brown, Ho Yi Wan

IdeaFest 2025

Samsung smart tags are used as a tool for tracking the location of mule deer and assessing their use in different environments with levels of urbanisation.