Digital Commons Network^™

Unh Research Team Finds Concentrated Pfas In Watershed Foams, Robbin Ray

Media Relations

No abstract provided.

The Lumberjack, February 19, 2025

Cal Poly Humboldt's Student Newspaper

The student newspaper of Humboldt State University.

Lindenwood Digest, February 19, 2025, Lindenwood University

Lindenwood Digest

The Lindenwood Digest has been a digital employee newsletter since 2009.

The Antelope, University Of Nebraska At Kearney

The Antelope

No abstract provided.

Therapy Combining Sorafenib And Natural Killer Cells For Hepatocellular Carcinoma: Insights From Magnetic Resonance Imaging And Histological Analyses, Zigeng Zhang, Guangbo Yu, Aydin Eresen, Qiaoming Hou, Sha Webster, Farideh Amirrad, Surya M. Nauli, Zhuoli Zhang

Pharmacy Faculty Articles and Research

Background/Objectives: Hepatocellular carcinoma (HCC) remains a significant global health issue due to its high mortality rate and resistance to standard treatments. Sorafenib, the first-line systemic therapy for unresectable HCC, shows limited effectiveness due to resistance and severe side effects. Recent studies suggest that combining sorafenib with immunotherapy, particularly natural killer (NK) cells, may improve treatment outcomes. Methods: This study examined the effectiveness of sorafenib combined with NK cells pretreated with interleukin-12 (IL-12) and interleukin-18 (IL-18) in a rat HCC model. Tumor progression and treatment outcomes were assessed using MRI and histological analysis. Results: The results show that …

Study To Understand The Effects Of Biofouling And Corrosion On Underwater Munitions: Implications For Risk Management And Resource Allocation, Center For International Stabilization And Recovery, Fenix Insight

Global CWD Repository

The project's primary objective is to understand the impacts of the underwater environment on munitions as a means to identify the residual risk these munitions pose, so people undertaking detection and clearance efforts can reliably assess operational risk and make informed decisions.

Chromosomal And Gonadal Sex Have Differing Effects On Social Motivation In Mice, Sneha M Chaturvedi, Simona Sarafinovska, Din Selmanovic, Katherine B Mccullough, Raylynn G Swift, Susan E Maloney, Joseph D Dougherty

2020-Current year OA Pubs

BACKGROUND: Sex differences in brain development are thought to lead to sex variation in social behavior. Sex differences are fundamentally driven by both gonadal hormones and sex chromosomes, yet little is known about the independent effects of each on social behavior. Further, mouse models of the genetic liability for the neurodevelopmental disorder MYT1L Syndrome have shown sex-specific deficits in social motivation. In this study, we aimed to determine if gonadal hormones or sex chromosomes primarily mediate the sex differences seen in mouse social behavior, both at baseline and in the context of Myt1l haploinsufficiency.

METHODS: Four-core genotypes (FCG) mice, which …

Trem2 Promotes Lung Fibrosis Via Controlling Alveolar Macrophage Survival And Pro-Fibrotic Activity, Huachun Cui, Sami Banerjee, Na Xie, Musaddique Hussain, Ashish Jaiswal, Hongli Liu, Tejaswini Kulkarni, Veena B Antony, Rui-Ming Liu, Marco Colonna, Gang Liu

2020-Current year OA Pubs

Lung macrophages play a pivotal role in pulmonary fibrosis, with monocyte-derived alveolar macrophages driving disease progression. However, the mechanisms regulating their pro-fibrotic behavior and survival remain unclear, and effective therapeutic strategies are lacking. Here we show that triggering receptors expressed on myeloid cells 2 are predominantly expressed on monocyte-derived alveolar macrophages in fibrotic mouse lungs and are significantly elevated in lung macrophages from patients with idiopathic pulmonary fibrosis. Deletion or knockdown of this receptor disrupts intracellular survival signaling, promotes macrophage apoptosis, and attenuates their pro-fibrotic phenotype. We further demonstrate that a lipid mediator and a high-avidity ligand of this receptor, …

Targeting Fatty Acid Synthase Reduces Aortic Atherosclerosis And Inflammation, Rodrigo Meade, Dina Ibrahim, Connor Engel, Larisa Belaygorod, Batool Arif, Fong-Fu Hsu, Sangeeta Adak, Ryan Catlett, Mingzhou Zhou, Ma Xenia G Ilagan, Clay F Semenkovich, Mohamed A Zayed

2020-Current year OA Pubs

Fatty acid synthase (FAS) is predominantly expressed in the liver and adipose tissue. It plays vital roles in de novo synthesis of saturated fatty acids and regulates insulin sensitivity. We previously demonstrated that serum circulating FAS (cFAS) is a clinical biomarker for advanced atherosclerosis, and that it is conjugated to low-density lipoproteins (LDL). However, it remains unknown whether cFAS can directly impact atheroprogression. To investigate this, we evaluate whether cFAS impacts macrophage foam cell formation - an important cellular process leading to atheroprogression. Macrophages exposed to human serum containing high levels of cFAS show increased foam cell formation as compared …

Phylogenetic Allometric Scaling Of Near Basal Breathing Frequency In Terrestrial, Semi-Aquatic And Aquatic Mammals, Andreas Fahlman, Elliot Stielstra, Ethan Wilstermann, Simon Rylaarsdam, Josefin Larsson, Guillermo J. Sanchez -Contreras, Suguru Higa, Gonçalo N. Marques, Malgosia Kaczmarska, Jason Somarelli, Stacy L. De Ruiter

University Faculty Publications and Creative Works

We measured the BASAL breathing frequency following an overnight fast in adult,non-pregnant/non-lactating, inactive mammals ranging in body mass from 15 to5520 kg. The data included results from 338 individual animals from 34 speciesthat were divided into terrestrial, semi-aquatic (Otariidae and Phocidae) and aquaticmammals. Following attempts to limit the collection of breathing frequency usinga basal definition and to correct the analysis phylogenetically, our results suggestthat there are differences in the allometric mass-exponent between terrestrial andaquatic/semi-aquatic mammals. An allometric regression model, whereby both bodymass and breathing frequency were transformed using log10 , suggested that theallometric mass exponent for terrestrial mammals (−0.303) was …

Purdue Stars Performance Analysis, Kayla Gurganus, Lynne Dahmen

Institute for a Sustainable Future Documents

This Sustainability Performance Analysis (SPA) report reviews Purdue’s past and present sustainability performance as captured through STARS reporting to understand sustainability actions and to clearly and objectively identify where Purdue excels and how it might improve performance through the next STARS 3.0 submission.

Office Of Research, Economic Engagement And Outreach Update, February 19, 2025, Office Of Research, Economic Engagement And Outreach

Office of Research, Economic Engagement and Outreach

No abstract provided.

The Role Of Non-Coding Rnas As An Innovative Therapeutic Tool For Hepatocellular Carcinoma, Nabila Mohamed Hosni El Kramani

Theses and Dissertations

Hepatocellular carcinoma (HCC) is the second lethal cancer worldwide, with over 60 million new patients added annually. Hepatitis B infection and toxins, e.g., aflatoxin, contribute to the incidence of HCC. Egypt and China show the highest prevalence of viral hepatitis and HCC in the world.

Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts larger than 200 nucleotides. These transcripts work at the transcriptional, post-transcriptional, and epigenetic levels to regulate gene expression by interacting with various biomolecules, such as RNA, DNA, and proteins. They serve essential functions in chromatin remodeling and cell survival, differentiation, and proliferation. The role and biological interactions of …

Integrating Planetary Health Into Public Health Education For Sustainable Healthcare Practices, Eman Aboualy

Theses and Dissertations

Introduction: Integrating planetary health in public health education became an urgent global call for action since the WHO announced that the climate change and environmental degradation are the most threat facing the humanity in the recent decades (1). According to that, many countries are developing strategies for counteracting and mitigating the impact of climate change and restore the planetary health. These strategies are including policy drafting and preparing their public health professionals to recognize and address the health effects of environmental change, promote practices for sustainable healthcare. Although Egypt is formulating different policies to cope with and respond to the …

Unh Research Team Finds Concentrated Pfas In Watershed Foams, Robbin Ray

UNH Today Archive

No abstract provided.

Consumer Acceptance Of Gene-Edited Food: The Role Of Knowledge, Trust, And Information, Anubrata Deka, Syed Imran Ali Meerza, Amalia Yiannaka

Cornhusker Economics

The research aims to assess consumer preferences and attitudes toward CRISPR applications in the food sector and estimate consumer willingness to pay for a food product developed using CRISPR technology to enhance food safety and confer health benefits. Additionally, the research assesses the impact of information provision on perceptions, attitudes and willingness to pay. Specifically, we consider the potential effect of both the nature of information provided (i.e., whether it emphasizes the differences between GM and CRISPR technology or not) and the delivery format (i.e., text versus video) used to present content-equivalent information. In this context, we also assess consumer …

Identification Of Novel Argonaute Proteins Using A Metagenomic Mining Approach, Lobna Abdallah Ghonaim

Theses and Dissertations

Gene editing is one of the most promising tools in science. It enables precise modifications of an organism's genetic material. Metagenomics is considered a powerful tool that unlocks the broad genetic potential found in uncultured microbial communities. Exploring the genetic diversity of uncultured microbial communities helps identify novel functional proteins with unique properties and make the best use of these diverse microbial ecosystems.

We developed and employed a metagenomic-based approach to mine more than 1000 metagenomes for prokaryotic argonaute proteins (pAgos), a potential gene editing machinery encoded in bacterial and archaeal genomes. Our workflow involved strict quality control, sequence assembly, …

Effect Of Multispecies Swards On The Fat Composition And Oxidative Stability Of Milk From Dairy Cows In Mid-Late Lactation, Samuel Rapisarda, Kate M. Mccarthy, Tommy M. Boland, Helen Sheridan, Frank J. Monahan, Finbar J. Mulligan, Graham O'Neill, Nissreen Abu-Ghannam

Articles

Multispecies swards have been recognized as more sustainable than traditional ryegrass systems, in addition to providing a range of phytochemicals to the ruminant diet. In this regard, polyphenols may be linked to higher levels of bioactive fatty acids in milk and enhanced nutraceutical properties in dairy products. This study compares the fat composition and oxidative stability of milk produced by cows fed on multispecies swards (MULTI) with milk from two conventional swards [a perennial ryegrass monoculture (PRG) and a mixture of perennial ryegrass and white clover (PRG + WC)] during the Irish summer. Milk from cows fed on MULTI had …

Development Of A Conditional Plasmid For Gene Deletion In Non-Model Fusobacterium Nucleatum Strains, Peng Zhou, Bibek G C, Chenggang Wu

Faculty, Staff and Student Publications

Fusobacterium nucleatum is an opportunistic pathogen with four subspecies: nucleatum (FNN), vincentii (FNV), polymorphum (FNP), and animalis (FNA), each with distinct disease potentials. Research on fusobacterial pathogenesis has mainly focused on the model strain ATCC 23726 from FNN. However, this narrow focus may overlook significant behaviors of other FNN strains and those from other subspecies, given the genetic and phenotypic diversity within F. nucleatum. While ATCC 23726 is highly transformable, most other Fusobacterium strains exhibit low transformation efficiency, complicating traditional gene deletion methods that rely on non-replicating plasmids. To address this, we developed a conditional plasmid system in which …

Benefits Of Equilibrium Between Microbiota- And Host-Derived Ligands Of The Aryl Hydrocarbon Receptor After Stroke In Aged Male Mice, Pedram Peesh, Maria P Blasco-Conesa, Ahmad El Hamamy, Romeesa Khan, Gary U Guzman, Parisa Honarpisheh, Eric C Mohan, Grant W Goodman, Justin N Nguyen, Anik Banerjee, Bryce E West, Kyung Ae Ko, Janelle M Korf, Chunfeng Tan, Huihui Fan, Gabriela D Colpo, Hilda Ahnstedt, Lucy Couture, Solji Roh, Julia K Kofler, Jose F Moruno-Manchon, Michael E Maniskas, Jaroslaw Aronowski, Rodney M Ritzel, Juneyoung Lee, Jun Li, Robert M Bryan, Anjali Chauhan, Venugopal Reddy Venna, Louise D Mccullough, Bhanu Priya Ganesh

Faculty, Staff and Student Publications

Recent studies have highlighted the crucial role of microglia (MG) and their interactions with the gut microbiome in post-stroke neuroinflammation. The activation of immunoregulatory pathways, including the aryl hydrocarbon receptor (AHR) pathway, is influenced by a dynamic balance of ligands derived from both the host and microbiota. This study aimed to investigate the association between stroke-induced dysbiosis and the resultant imbalance in AHR ligand sources (loss of microbiota-derived [indole-based] and increase of host-derived [kynurenine-based]) after stroke. Microbiota-derived AHR ligands decreased in human plasma and remained low for days following an ischemic stroke highlighting the translational significance. Transient-middle-cerebral-artery-occlusion was performed in …

Rural Entrepreneurship In Upper Egyptian Communities: Exploring The Intervention Of Agri-Tech Startups, Marwa Wael Abohamda Hulail

Theses and Dissertations

Climate change and economic disturbance have changed the state of the world and increased the dependence on digitization in running people's daily life. In Egypt, the economic instability and climate change have affected people’s standard of living, making it challenging to sustain their life, especially in the agriculture sector. Farmers have been affected by the risks of climate change, economic shocks, and trends of digitization, which have impacted their profit, employability, and livelihood.

Several Egyptian Agri-tech startups were launched to support the farmers in the digital revolution that came to agriculture, attempting to make a change in the Egyptian farming …

Mir-125a-3p And Its Targets: Promising Biomarkers For Ovarian, Liver, And Breast Cancers, Offering A Beacon Of Hope For More Effective Diagnosis And Treatment Strategies, Eman Kamaleldien Anwer

Theses and Dissertations

Cancer is a worldwide health problem with various genetic and epigenetic alterations, resulting in disease heterogeneity. Effective diagnostic, therapeutic, and monitoring markers have been determined recently; however, new diagnostic, prognostic, and therapeutic markers are needed. MicroRNAs (miRNA), short non-coding RNAs, have a highlighted role in cancer progression, migration, and programmed cell death. Our study aims to investigate the significance of miR-125a-3p and its downstream targets in breast (BRCA), hepatocellular (HCC), and ovarian (OVCA) malignancies and their possibility as diagnostic biomarkers and targets for therapeutic agents. Bioinformatics and online tools were used to determine the miRNA-predicted downstream targets, analyze GEO datasets, …

Commensality In The Eateries Of Roman Pompeii, Amaya Yolanda Eckersley

Dissertations and Theses

Despite a nearly 300-year excavation history at Pompeii and many identified eating and drinking establishments, social behavior in these public or semi-public spaces has eluded significant research. Elite Roman literature is the traditional guideline for understanding Roman mealtimes and what they meant for social behavior. This literature, however, fails to accurately represent its sub-elite inhabitants. These sub-elites of Rome largely had their meals prepared outside of their homes. Pompeii is no exception and provides a massive boon for researchers willing to consider archaeological evidence. The buildings and evidence buried at Pompeii have ultimately shown a wide array of tabernae related …

What Knowledge Resources Do General Chemistry Students Use To Agree Or Disagree With Atomic Level Acid–Base Animations?, Resa M. Kelly, John H. Kim, Adrian Villalta-Cerdas, Sarah J.R. Hansen, Sevil Akaygun

Faculty Research, Scholarly, and Creative Activity

Atomic-level visualizations serve as pivotal instructional tools in chemistry education, providing insights into the particulate level of matter, a dimension fundamental, yet typically invisible, in the study of chemistry. This research investigates how students’ engagement with these visualizations influences their conceptual understanding of atomic-level phenomena. Specifically, it examines the knowledge resources used by college chemistry students (n = 15), both current and former General Chemistry students, to agree with visual representations when confronted with conflicting animations depicting atomic level acid–base neutralization reactions. Employing an epistemological framework, the study analyzed video recordings of students constructing and articulating their models and subsequently …

Silencing Faf2 Mitigates Alcohol-Induced Hepatic Steatosis By Modulating Lipolysis And Pcsk9 Pathway, Nazmul Huda, Praveen Kusumanchi, Yanchao Jiang, Hui Gao, Themis Thoudam, Ge Zeng, Nicholas J. Skill, Zhaoli Sun, Suthat Liangpunsakul, Jing Ma, Zhihong Yang

School of Medicine Faculty Publications

BACKGROUND: Chronic alcohol consumption leads to lipid accumulation, oxidative stress, cellular damage, and inflammation in the liver, collectively referred to as alcohol-associated liver disease (ALD). FAF2/UBXD8/ETEA (Fas-associated factor 2) is a ubiquitin ligase adaptor protein that plays a crucial role in the ubiquitin-mediated degradation of misfolded proteins in the endoplasmic reticulum. A recent genome-wide association study indicated an association between FAF2 and ALD; however, the exact contribution of FAF2 to ALD pathogenesis remains unclear. METHODS: FAF2 was knocked down using AAV-delivered shRNA in C57/BL6 mice. Mice were subjected to a chronic-plus-single binge ethanol feeding (NIAAA) model. Nine hours after gavage, …

Shock Effects Including Maskelynite Formation In Three Shergottite Meteorites From Mars, George Ayeh Anim

Dissertations and Theses

Martian meteorites result from large impact events on the surface of Mars that cause intense shock metamorphism. This study examines the shock metamorphic features of three shergottite meteorites, Dho 019, NWA 12241, and NWA 15628, to better understand shock impact events. The research uses petrographic analysis, scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), and electron backscatter diffraction (EBSD) to analyze the meteorites. A key focus of this research is the formation of maskelynite, a glass with plagioclase composition, whose formation mechanism has been the substance of debate among researchers. This study proposes that maskelynite forms through a transient intermediary …

Investigating The Relationship Between The Circadian Clock, Age, And Lifestyle, Samuel Park, Amaka Eziakonwa, Amega Nguyen, Madison Payne, Erich Stahmer, Alexis Salinas, Payson Broome, Angel Oliver, Christian Mccormick, Jasmyn Brown, Julie A. Zacharias-Simpson, Jutta Ward, Deborah Bell-Pedersen

Annual Research Symposium

This poster presentation aims to understand how circadian clock strength and phase are affected by age and lifestyle. By analyzing changes in physiological rhythms, the study seeks to develop strategies for promoting healthy aging by optimizing circadian function.

Evaluation Of A Global Capacity Development Project To Educate, Empower And Advance Sustainable Food Production, Felicia J. Tuggle, Olubusola W. Afolayan Msw, Mollie Smith M.Aq., David J. Cline Phd, Onesimus Kiadii Bs

Journal of Social Work in the Global Community

This article presents evaluation findings from the Integrated Aquaculture for Food Production, Education, Empowerment, and Development (iFEED) project, a global capacity development project designed to educate, empower, and advance sustainable food production in Monrovia, Liberia. To develop K–12 teachers’ capacity to integrate STEM education into math and science curriculum for the purpose of preparing a future aquaculture workforce in Liberia, the iFEED project provided educational materials, teacher training, and technical support to 25 teachers in the greater Monrovia Consolidated School District (MCSS). Evaluation findings indicate positive outcomes in increasing instructional capabilities among participating math and science teachers and accelerating action …

The United States' Recycling Model Is In Desperate Need Of A Makeover, Lindsay A. Williamson

Widener Commonwealth Law Review

Most Americans do not hesitate to throw something away, but a lack of recycling is causing landfills to overflow with products that could be reused and repurposed. In 2017, it was estimated that the average American creates 4.51 pounds of garbage per day, nearly double the amount of the 2.68 pounds Americans produced on average in 1960. Recycling in the United States has become problematic as recycling companies turn away recyclables that have been contaminated with food and other nonrecyclables. The effect is that not nearly enough recyclable products are being repurposed, with many of them ending up in landfills. …

Yes, Your Broken Tailight Does Matter: Why Enforcement Of Minor Traffic Violations Is Integral For A Safe Society, Richard E. Berner

Widener Commonwealth Law Review

“At his best, man is the noblest of all animals; separated from law and justice he is the worst.” These words serve as a reminder that within the framework of law and order, human beings are the most spectacular creatures to walk the face of the Earth. Outside of this framework, we are no greater than the most savage of beasts. The United States has historically faced challenges with the presence of racial bias within the legal system. In particular, traffic laws have been subject to uneven enforcement across the country, with one study indicating that black drivers were approximately …