Digital Commons Network^™

Superior Preclinical Efficacy Of Co-Treatment With Brg1/Brm And Flt3 Inhibitor Against Aml Cells With Flt3 Mutations, Warren Fiskus, Christopher P Mill, Jessica Piel, Mike Collins, Murphy Hentemann, Branko Cuglievan, Christine E Birdwell, Kaberi Das, Hanxi Hou, John A Davis, Antrix Jain, Anna Malovannaya, Tapan M Kadia, Naval Daver, Koji Sasaki, Koichi Takahashi, Danielle Hammond, Patrick K Reville, Lauren B Flores, Sanam Loghavi, Xiaoping Su, Courtney D Dinardo, Kapil N Bhalla

Faculty, Staff and Student Publications

Although treatment with standard frontline therapies, including a FLT3 inhibitor (FLT3i) reduces AML burden and achieves clinical remissions, most patients with AML with FLT3 mutation relapse due to therapy-resistant stem/progenitor cells. The core ATPases, BRG1 (SMARCA4) and BRM (SMARCA2) of the canonical (c) BAF (BRG1/BRM-associated factor) complex is a dependency in AML cells, including those harboring FLT3 mutations. We have previously reported that treatment with FHD-286, a BRG1/BRM ATPases inhibitor, induces differentiation and loss of viability of AML stem/progenitor cells. Findings of present studies demonstrate that treatment with FHD-286 induces lethality in AML cells, regardless of sensitivity or resistance to …

Empowering Young Innovators Through School-Based Agricultural Education: Insights From A Nigerian Secondary School Teacher, Mary O. Olumide-Oyaniyi

National Collaborative for Research on Food, Energy, and Water Education (NC-FEW)

Nigeria faces challenges like food insecurity and economic instability, worsened by a growing youth population. School-Based Agricultural Education (SBAE) engages youth in agricultural innovations. This study implemented SBAE principles in a Nigerian school, combining poultry farming and aquaculture. Students managed a poultry farm, using chicken droppings to breed maggots as feed for catfish in rainwater-filled tanks. The project enhanced students' skills, improved local food production, and engaged the community. Despite funding and management challenges, the initiative demonstrated SBAE's potential to empower youth and advance agricultural practices, offering a model for similar projects in other regions.

The Few-Nexus: Using Soil To Grow Meaning And Relevance In Undergraduate General Education Earth Science Courses, Katherine Mccarville

National Collaborative for Research on Food, Energy, and Water Education (NC-FEW)

Soils are central to human survival, through their critical roles in regulating water supplies and providing the medium for most agricultural productivity. Even as fewer and fewer students know where their water and food come from, and where their wastes go, soils tend to be under-emphasized in Earth science general education courses. Combining a place-based focus on soils with the FEW-Nexus model provides an integrating context for concepts and information that students sometimes perceive as disconnected and irrelevant to them. This approach can transform the experiences and learning of undergraduate students in the Earth science general education curriculum.

Learning Food Supply Chains Through Generative Ai – Tips, Techniques, And Student Perceptions, Subbu Kumarappan, Urmila Pal Chaudhuri

National Collaborative for Research on Food, Energy, and Water Education (NC-FEW)

The classroom pedagogies are evolving significantly with Generative Artificial Intelligence (GenAI). The students in a Food Supply Chains class completed a project for various agricultural products describing 12 factors and 7 supply chain principles. They reflected on the use of GenAI and how it impacted their knowledge and critical thinking skills. The students scored GenAI high on ‘relevancy, diverse topics, significance, and sufficiency;' the repeated use of GenAI for food supply chains enabled them recognize the importance of sustainability and ESG factors in the management of natural resources. There were differences in students use and benefits with GenAI use.

Integrating The Few-Nexus Into An Agricultural Issues Course, Christopher M. Estepp, Hannah Scherer

National Collaborative for Research on Food, Energy, and Water Education (NC-FEW)

To address the global challenges facing the agricultural industry, graduates of agricultural degree programs must learn to utilize systems thinking skills, which can help them view the interconnectedness among issues and design holistic solutions. The Food-Energy-Water (FEW)-Nexus is an interdisciplinary framework that can support undergraduate student achievement of sustainability education competencies, including systems thinking. This project utilized the FEW-Nexus framework in an agricultural issues course to help students improve their systems thinking. Students were given lectures on various agricultural issues by experts in those areas. Two assignments, agricultural issue concept maps and critical reflections over each speaker’s session were completed …

Harriet Beecher Stowe: Saints And Sinners Analysis Of The Moral Suasion And Motivations Behind The Creation Of Uncle Tom's Cabin, Makendric James Bowman

Student Summer Scholars Manuscripts

This project examines the motivations behind Harriet Beecher Stowe’s Uncle Tom’s Cabin (UTC), focusing on how her desire for both financial gain and moral reform shaped her writing. Stowe’s use of religious themes to expose the moral and human costs of slavery positioned her novel at the center of national debate, forcing both defenders and opponents of slavery to confront uncomfortable truths. Her book ultimately made her the best-selling author of the 19th century, selling 300,000 copies mostly by door-to-door subscriptions. This is equivalent to about 4.4 million Americans today who do not have access to Amazon or bookstores. Even …

Rehydrating The Church: The Lifegiving Role Of The Holy Spirit In Christian Formation, Ministry, Leadership, And Community, Rand Burden

Doctor of Ministry

NPO Statement

Many small rural Global Methodist Church (GMC) congregations have limited access to pastors and, as such, are in critical need of alternative forms of spiritual leadership.

Key Insights

Life in the Spirit must precede spiritual leadership. The church desperately needs members and leaders living lives led by, walking after, and informed by the Spirit. It is my conviction that with an increased awareness of the Spirit, a desire for intimacy will arise, a drawing to wade into the Water of Life, to be more open to desire and experience a deeper encounter with and understanding of the Holy …

The Bison, March, 14, 2025

The Bison Newspapers

No abstract provided.

Ucc Minutes Mar 14, 2025, Undergraduate Curriculum Committee

Undergraduate Currirculum Committee Minutes

No abstract provided.

Doc 2025-02 Neuroscience Co-Major, Full Program Proposal, University Of Dayton. Department Of Biology, College Of Arts & Sciences

Senate Documents

The Department of Biology in the College of Arts & Sciences (CAS) proposes to establish an innovative Co-Major in Neuroscience program. This Co-Major will comprise a new program offering in the Department of Biology complementing the existing Minor in Neuroscience.

March 14, 2025, Csusb

Coyote Chronicle (1984-)

No abstract provided.

Physical And Biological Effects On Moths’ Navigation Performance, Yiftach Golov, Roi Gurka, Alexander Liberzon, Ally Harari

Physics and Engineering Science

In a chemosensing system, the local olfactory environment experienced by a foraging organism is defined as an odorscape. Using the nocturnal pink bollworm moth (Pectinophora gossypiella), we tested the combined effect of three biophysical aspects in its immediate odorscape to shed light on the coupling effects of biotic and abiotic factors on navigation performances of a nocturnal forager: i) the quality of the pheromone source, ii) the pheromone availability, and iii) the airflow characteristics. The navigation performance of the males was investigated using a wind tunnel assay equipped with 3D infrared high-speed cameras. The navigation performance of the males was …

2025-3-14 Minutes Of The Academic Senate, University Of Dayton. Academic Senate

Academic Senate Minutes

Approved minutes of a meeting of the Academic Senate of the University of Dayton.

Refugium Amidst Ruins: Unearthing The Lost Flora That Escaped The End-Permian Mass Extinction, Huiping Peng, Wan Yang, Mingli Wan, Jun Liu, Feng Liu

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Searching for land refugia becomes imperative for human survival during the hypothetical sixth mass extinction. Studying past comparable crises can offer insights, but there is no fossil evidence of diverse megafloral ecosystems surviving the largest Phanerozoic biodiversity crisis. Here, we investigated palynomorphs, plant, and tetrapod fossils from the Permian-Triassic South Taodonggou Section in Xinjiang, China. Our fossil records, calibrated by a high-resolution age model, reveal the presence of vibrant regional gymnospermous forests and fern fields, while marine organisms experienced mass extinction. This refugial vegetation was crucial for nourishing the substantial influx of surviving animals, thereby establishing a diverse terrestrial ecosystem …

Exploring The Mechanistic Interplay Between Chronic Inflammation And Gastrointestinal Cancer In The Gut Microbiome: A Review, Hanan Mohamed Abd Elmoneim

Saudi Toxicology Journal

There are complex and heterogeneous immunological milieus of the gastrointestinal system, so there is a high mortality rate from malignancies affecting the gastrointestinal system. The pathophysiology of cancer has long been thought to be significantly influenced by inflammation. However, several of the mechanisms underlying its tumor-promoting activities have only lately been discovered. Both beneficial and harmful microorganisms play a crucial role in controlling the host immune system and, eventually, inflammation. Furthermore, bacteria may also influence how a tumor develops through different mechanisms, including long-term inflammation activation, changes to the tumor microenvironment, and genotoxic response induction. A significant percentage of cancers …

“Smart Trap”: A Portable Device For Real-Time Mosquito Capturing And Classification Using Image-Based Analysis, Fahim Rahman

USF Tampa Graduate Theses and Dissertations

Capturing mosquitoes in real-time and taking high-quality images for classification with state-of-the-art methods is not only time-consuming but also expensive. Sometimes even carefully controlled environments and experimental setups fail to capture living mosquitoes. Catching live mosquitoes is necessary to be able to study aspects of their physiology and behavior that cannot be investigated by collections of resting mosquitoes and dead specimens, and to help estimate the local population numbers. My thesis introduces a “Smart Trap”, a small portable device that can attract mosquitoes in real-time, capture them, take high-quality images with dual cameras, and store those images in the cloud. …

Distributed Repeaters For Extending The Range Of Harmonic Rf Tags, Trevor Saunders

USF Tampa Graduate Theses and Dissertations

Passive harmonic Radio Frequency (RF) tags are highly advantageous compared to theiractive counterparts due to their ability to operate effectively in environments that are cluttered or where access to the tag for battery maintenance is challenging, dangerous and/or time consuming. They are also resistant to the local oscillator (LO) phase noise in radar applications where the doppler frequency from slow moving targets is buried beneath the noise. One of the major constraints of passive harmonic RF tags, however, lies in their operating range and the significant amount of power required to overcome the conversion loss and activate the nonlinear device …

The Sustainability Stones: Culturally Embedded Conservation Strategies And Their Vulnerability In Maupiti, French Polynesia, Russell Fielding, Fiona Gimenez

Honors College Faculty Publications

This paper explores culturally embedded conservation strategies through the lens of the traditional agroforestry and fisheries cycles in Maupiti, French Polynesia. By pairing certain breadfruit cultivars with specific fish species, the island’s community created a culinary system that regulates the seasonal consumption of marine resources, making the sustainable use of those resources more likely. While modern pressures such as reduced breadfruit diversity, competition with imported foods, and climate change have weakened these traditional practices, they remain an example of local ecological knowledge guiding conservation. The study highlights the threat of losing sustainable resource-use practices and biodiversity as both biodiversity and …

Mirrors For Pacific Islander Children: Teaching Resilience Through Culturally Adapted Bibliotherapy, Isabel Medina Hull, Elizabeth Cutrer, Paul H. Ricks, G. E. Kawika Allen, Kendra M. Hall-Kenyon, Lorena Seu, Kristopher J. Urbina, Melia Fonoimoana Garrett

Faculty Publications

Pacific Islander youth face disproportionately high rates of suicide and mental health challenges, yet culturally appropriate interventions remain scarce. This study investigated whether culturally adapted bibliotherapy could effectively promote resilience in American Samoan children by incorporating culturally relevant stories and coping strategies. Through collaboration with on-island Samoan cultural brokers, we developed and implemented culturally adapted stories and lessons designed to resonate with the experiences of children in American Samoa. The study employed a mixed-methods approach with 34 American Samoan children aged 5–13 years, using observations, adapted card sorts, and forced-choice procedures to measure responses to the intervention. The results demonstrated …

Glucagon-Like Peptide-1 Receptor Agonists: Exciting Avenues Beyond Weight Loss, Lalitha Sundararaman, Divakara Gouda, Anil Kumar, Sumithra Sundararaman, Basavana Goudra

Department of Anesthesiology Faculty Papers

The last two decades have proffered many remarkable choices in managing type 1 and type 2 diabetes mellitus. Leading the list are glucagon-like peptide-1 receptor agonists (GLP1RAs), the first of which, exenatide, was approved by the FDA in 2005. Two other major classes of drugs have also entered the market: dipeptidyl peptidase-4 (DPP-4) inhibitors, commonly known as gliptins and approved in 2006, and sodium-glucose cotransporter-2 (SGLT-2) inhibitors, with the first approval occurring in 2013. These drugs have revolutionized the treatment of diabetes. Additionally, on the horizon, the once-weekly basal insulin analog insulin icodec and the once-weekly combination of insulin icodec …

Juvenile And Adult Survival Estimates Of American Kestrels Throughout The Full Annual Cycle In Eastern North America, Mercy Melo, Joseph M. Kolowski, Rebecca A. Mccabe, John A. Smallwood, Allison Cornell, David King, Jean François Therrien

Department of Biology Faculty Scholarship and Creative Works

Measuring survival in a declining species provides the foundation for continued research, demographic modeling, and informed conservation strategies. Although American Kestrel (Falco sparverius) populations have continued to decline since the 1970s, little is known about their survival throughout the full annual cycle, making it difficult to identify factors responsible for these declines. We used radio telemetry to provide the first known-fate estimates of adult kestrel survival, and we present data across breeding stages, and between resident and migratory wintering individuals, in addition to separately modeling fledgling survival. Temporal and spatial stratification of study sites allowed for the investigation of different …

Co-Sleeping With A Pet: Exploring The Impact On Youth Sleep, Brittany D. Lancaster, Tristen Hefner, Jason Van Allen

Publications

Objective: Despite a rise in pet ownership and adult literature indicating pet co-sleeping may lead to disrupted sleep, limited research has evaluated the impact of youth co-sleeping with an animal. This study evaluated whether a pet in the bedroom affects youth sleep. Methods: 175 families completed measures of screen time, sleep problems, and parental sleep knowledge. Youth (M age = 9.51; 53.1% male) wore an ActiGraph and completed a sleep diary for 2 consecutive weeks. For youth who owned a pet dog, the dog wore an ActiGraph for the same 2 weeks. Youth were separated into 3 groups: those who …

Beloved Elder: The Spiritual Journey Of Aging, Elizabeth Nielsen

Doctor of Ministry

Aging has changed significantly in recent decades due to medical, economic, and social factors. The increasing length of American lives is both a blessing and a challenge for families and elders themselves, but our cultural and theological foundations are not sufficient to address this situation.

My NPO emerged from pastoral experience caring for elders: Aging Christians often struggle to know the presence and love of God finding their faith practices to be inadequate for the distinctive challenges of aging.

Key insights from my research include:

1. The most significant challenge of aging is surrender to childlikeness before God. In late life …

High-Throughput Repurposing Screen Reveals Compounds With Activity Against Toxoplasma Gondii Bradyzoites, Taher Uddin, Jing Xia, Yong Fu, Case W Mcnamara, Arnab K Chatterjee, L David Sibley

2020-Current year OA Pubs

No abstract provided.

‘Malaysia’ Resurveyed: From Representation And Separation To Alternative Tropical Futurities, Wai Liang Tham

Research Publications (2021 to 2025)

This essay, in the form of a literary survey,revisits the idea of “Malaysia” by examining how the interlinked practices of representation and separation have been fundamental to the reification of tropicalityin the region once known as the Malay Archipelago: contemporary maritime Southeast Asia. It suggests how the two contradictory facets of colonial-era tropicality as envisioned in British Malaya (i.e., a fecund wasteland and inescapable degradation) have become embedded in the logic of governance in postcolonial Malaysia and Singapore. The persistent effects of this discourse in the present are discussed in terms of the challenges facing mobilization over issues of climate …

Strategies To Improve Antibody-Mediated Protection Against Herpes Simplex Virus Infections, Matthew D. Slein

Dartmouth College Ph.D Dissertations

No efficacious vaccine exists for herpes simplex virus and the global burden of disease remains high. Antibodies can serve as potent therapeutics to protect high risk populations such as neonates. Although rare, neonatal HSV (nHSV) infections can result in significant mortality and lifelong neurological morbidity even with antiviral therapy. While HSV-specific maternally derived antibodies significantly reduce the risk of neonatal disease in humans, the mechanisms by which they mediate protection have yet to be described. Using a mouse model of neonatal HSV (nHSV) infections we aimed to determine the mechanisms of antibody-mediated protection using monoclonal antibodies (mAbs) targeting two of …

Protracting The Immediate: Time As Form In Contemporary Horror, Kennedy Kelley

USF Tampa Graduate Theses and Dissertations

This thesis examines the expression and experience of temporality in horror films of the last decade. Whereas early twenty-first century horror was characterized by high-octane jump scares, current horror is marked by contemplative slowness. I argue that the elongated duration of recent horror extends an experience of indeterminate anxiety that attunes us to an expansive relationality, offering a corrective not only to contemporary logics of immediacy, but also to the frequently constricting nature of embodiment as a theoretical concept. Recent horror scholarship tends to center sensuous propinquity in response to a long history of gaze theory’s disembodied passivity. While these …

Tunneling Nanotube-Like Structures Regulate Distant Cellular Interactions During Heart Formation, Lianjie Miao, Yangyang Lu, Anika Nusrat, Guizhen Fan, Shaohua Zhang, Luqi Zhao, Chia-Ling Wu, Hongyan Guo, Trang Le Nu Huyen, Yi Zheng, Zhen-Chuan Fan, Weinian Shou, Robert J Schwartz, Yu Liu, Ashok Kumar, Haixin Sui, Irina I Serysheva, Alan R Burns, Leo Q Wan, Bin Zhou, Sylvia M Evans, Mingfu Wu

Faculty, Staff and Student Publications

In the developing mammalian heart, the endocardium and the myocardium are separated by so-called cardiac jelly. Communication between the endocardium and the myocardium is essential for cardiac morphogenesis. How membrane-localized receptors and ligands achieve interaction across the cardiac jelly is not understood. Working in developing mouse cardiac morphogenesis models, we used a variety of cellular, imaging, and genetic approaches to elucidate this question. We found that myocardium and endocardium interacted directly through microstructures termed tunneling nanotube-like structures (TNTLs). TNTLs extended from cardiomyocytes (CMs) to contact endocardial cells (ECs) directly. TNTLs transported cytoplasmic proteins, transduced signals between CMs and ECs, and …

Expression Of A Single Inhibitory Member Of The Ly49 Receptor Family Is Sufficient To License Nk Cells For Effector Functions, Sytse J Piersma, Shasha Li, Pamela Wong, Michael D Bern, Jennifer Poursine-Laurent, Li-Ping Yang, Diana L Beckman, Bijal A Parikh, Wayne M Yokoyama

2020-Current year OA Pubs

Natural killer (NK) cells recognize target cells through germline-encoded activation and inhibitory receptors enabling effective immunity against viruses and cancer. The Ly49 receptor family in the mouse and killer immunoglobin-like receptor family in humans play a central role in NK cell immunity through recognition of major histocompatibility complex class I (MHC-I) and related molecules. Functionally, these receptor families are involved in the licensing and rejection of MHC-I-deficient cells through missing-self. The Ly49 family is highly polymorphic, making it challenging to detail the contributions of individual Ly49 receptors to NK cell function. Herein, we showed mice lacking expression of all Ly49s …

Sustainable Sediment Management In Jordanian Dams: Feasibility, Economic Viability, And Agricultural Reuse Potential, Ahmed Al-Taani, Nazem El Radaideh, Wesam Al Kateeb, Fares Howari, Yousef Nazzal, Jibran Iqbal, Abeer Al Bsoul

All Works

Jordan has long faced severe water scarcity, which has significant implications for agriculture, industry, and domestic consumption. This crisis is further exacerbated by climate change, population growth, regional conflicts, and unsustainable water use. In response, Jordan has focused heavily on dam construction to secure water supplies, despite the high financial and environmental costs. However, rapid sedimentation threatens dam storage capacity and operational efficiency, reducing their lifespan and long-term sustainability. This study evaluates the feasibility of sediment removal as an alternative to constructing new dams, considering environmental, technical, agricultural, and economic factors. The research is based on case studies from King …