Digital Commons Network^™

The Placenta Regulates Intrauterine Fetal Growth Via Exosomal Pparγ, Xiaofang Luo, Biao Huang, Ping Xu, Hao Wang, Baozhen Zhang, Li Lin, Jiujiang Liao, Mingyu Hu, Xiyao Liu, Jiayu Huang, Yong Fu, Mark D Kilby, Rodney E Kellems, Xiujun Fan, Yang Xia, Philip N Baker, Hongbo Qi, Chao Tong

Faculty, Staff and Student Publications

Abnormal adipogenesis is a major contributor to fetal growth restriction (FGR) and its associated complications. However, the underlying etiology remains unclear. Here, it is reported that the placentas of women with pregnancies complicated with FGR exhibit peroxisome proliferator-activated receptor γ (PPARγ) inactivation. In mice, trophoblast-specific ablation of murine PPARγ reproduces the phenotype of human fetuses with FGR and defective adipogenesis. Coculture of trophoblasts with preadipocytes significantly improves preadipocyte commitment and differentiation and increases the transcription of a series of adipogenic genes via intercellular transfer of exosomal PPARγ proteins. Moreover, nanoparticle-mediated placenta-specific delivery of rosiglitazone (RGZ) significantly rescues adipogenesis defects in …

Calcium-Sensing Receptor As A Novel Target For The Treatment Of Idiopathic Pulmonary Fibrosis, Kasope Wolffs, Renjiao Li, Bethan Mansfield, Daniel A Pass, Richard T Bruce, Ping Huang, Rachel Paes De Araújo, Bahareh Sadat Haddadi, Luis A J Mur, Jordanna Dally, Ryan Moseley, Rupert Ecker, Harry Karmouty-Quintana, Keir E Lewis, A John Simpson, Jeremy P T Ward, Christopher J Corrigan, Renata Z Jurkowska, Benjamin D Hope-Gill, Daniela Riccardi, Polina L Yarova

Faculty, Staff and Student Publications

Idiopathic pulmonary fibrosis (IPF) is a disease with a poor prognosis and no curative therapies. Fibroblast activation by transforming growth factor β1 (TGFβ1) and disrupted metabolic pathways, including the arginine-polyamine pathway, play crucial roles in IPF development. Polyamines are agonists of the calcium/cation-sensing receptor (CaSR), activation of which is detrimental for asthma and pulmonary hypertension, but its role in IPF is unknown. To address this question, we evaluated polyamine abundance using metabolomic analysis of IPF patient saliva. Furthermore, we examined CaSR functional expression in human lung fibroblasts (HLFs), assessed the anti-fibrotic effects of a CaSR antagonist, NPS2143, in TGFβ1-activated normal …

The Interaction Between Antithrombin And Endothelial Heparan Sulfate Mitigates Pulmonary Thromboinflammation After Trauma And Hemorrhagic Shock, Maria Del Pilar Huby Vidaurre, Ava K Mokhtari, Baron K Osborn, Bryan A Cotton, Yao-Wei Wang, Yongmei Xu, Katelyn Arnold, Jian Liu, Jillian R Richter, Jessica C Cardenas

Faculty, Staff and Student Publications

Introduction:

Trauma and hemorrhagic shock (T/HS) are associated with multiple organ injury. Antithrombin (AT) has anti-inflammatory and organ protective activity through its interaction with endothelial heparan sulfate containing a 3-O-sulfate modification. Our objective was to examine the effects of T/HS on 3-O-sulfated (3-OS) heparan sulfate expression and determine whether AT-heparan sulfate interactions are necessary for its anti-inflammatory properties.

Methods:

Male Sprague Dawley rats underwent laparotomy, gut distension and fixed-pressure hemorrhagic shock (HS) and resuscitation. Liquid chromatography-coupled mass spectrometry analyses were performed to measure pulmonary and plasma heparan sulfate di/tetrasaccharides. Pulmonary mRNA levels were assessed by nCounter …

Il13rα2-Targeting Antibodies For Immuno-Pet In Solid Malignancies, Leah Gajecki, Irina V Lebedeva, Yu-Rou Liao, Daisy Ambriz, Lukas M Carter, Melina Kumpf, Samantha Lovibond, Justin S Hachey, Maya S Graham, Michael Postow, Jason S Lewis, David P Andrew, Manuel Baca, Heiko Schöder, Steven M Larson, Darren R Veach, Simone Krebs

Faculty, Staff and Student Publications

Interleukin-13 receptor α-2 (IL13Rα2) is a cell surface receptor frequently expressed in solid malignancies, such as glioblastoma and melanoma, with limited expression in healthy tissue, rendering it an ideal target for noninvasive and specific tumor delineation. In this study, we report the development of 5 novel IL13Rα2-targeted human monoclonal antibodies (mAbs) KLG-1-5; in subsequent in vitro and in vivo studies after radiolabeling with 89Zr, we evaluate their performance to identify a lead candidate.

Methods: Five novel human anti-IL13Rα2 mAbs KLG-1-5 were developed and in vitro binding properties and target specificity assessed. In vivo 89Zr-immuno-PET using KLG-1-5 was conducted in a …

Age-Associated Proteins Explain The Role Of Medial Temporal Lobe Networks In Alzheimer’S Disease, Adam Turnbull, Yejin Kim, Kai Zhang, Xiaoqian Jiang, Zihuai He, Victor W Henderson, F Vankee Lin

Faculty, Staff and Student Publications

The structural connectivity (SC) of the medial temporal lobe and its associated cortical anterior temporal and posterior medial networks (MTL-AT-PM) is linked to pathologies and memory decline in Alzheimer's disease (AD). However, neuroimaging analyses cannot tell us how SC changes occur in AD at the molecular level and do not provide a means of intervening to slow/prevent pathology-related changes in MTL-AT-PM SC. The current study aimed to understand how and where AD-related changes occur within MTL-AT-PM using proteomics. We used a 4-step approach in 101 older adults from a local sample, aiming to understand how proteins and SC in combination …

Graphic Design Is (Not) My Passion: How A Hypothetical Wedding Website Upended Lgbtq+ Public Accommodations Law And Where We Go From Here, Skylar Corby

Cardozo Journal of Equal Rights & Social Justice

The note examines the implications of the Supreme Court's decision in 303 Creative LLC v. Elenis, which upheld the First Amendment protection for a website designer refusing to create designs contrary to her beliefs, thereby invalidating part of Colorado's antidiscrimination law. This ruling undermines LGBTQ+ public accommodations protections, highlighting the need for federal legislation, such as the Equality Act, to safeguard these rights and address First Amendment concerns.

For The Birds, Charlotte L. Middleton

School of Art, Art History, and Design: Theses and Student Creative Work

For the Birds is a homogenous material exhibition of porcelain pottery that explores the relationships between, expectations of, and roles placed upon women and pottery. Using traditional craft processes, still life imagery, and the language and limits of porcelain, I create arrangements that expose the viewers assumptions of both subjects. Pottery- pitchers, cups, and vases—is a product of anthropocentrism and anthropomorphism and can be entirely taken for granted- their role is assumed and unquestionable—to serve. The language and expectations of these objects are the medium I build with.

The title of the show, For the Birds, is both a …

Aesop Under L'Oreal: Growth Vs. Brand Integrity, Gowrav Ghatamaneni, Spencer Godina, Reed Mchenry, Cole Miller, Shruti Pradeep

B-Corp Case Studies by UNL Raikes Seniors

Founded in Melbourne, Australia, in 1987, Aesop has emerged as a global luxury skincare brand known for its minimalist packaging, commitment to sustainability, and sensory in-store experience. In 2023, L'Oréal Groupe acquired Aesop from Natura & Co. in a deal valued at $2.5 billion, marking the largest acquisition in L'Oréal's history. The brand's dedication to aesthetics has set it apart in the competitive beauty industry. But how does a brand built on small-scale, curated retail experiences navigate the expansion driven by a multinational owner? Can Aesop maintain its core values while scaling up?

Nanosilica Supplementation In Tomato Increases Oviposition On Stems And Caterpillar Mortality In The Tomato Pinworm, Kokou R. Fiaboe, Fathiya M. Khamis, Xavier Cheseto, Abdullahi A. Yusuf, Baldwyn Torto

All Peer-Reviewed Publications

Silicon-induced responses play a key role in plant defense against herbivory, though the underlying mechanisms remain underexplored. In this study, we examined how mesoporous silica nanoparticles (MSNs) affect tomato (Solanum lycopersicum) defense against an invasive and highly destructive lepidopteran herbivore, the tomato pinworm (TPW), Phthorimaea absoluta. In tomato plants supplemented with MSN, prior exposure to TPW oviposition shifted subsequent egg-laying from a preference for leaves to an even distribution between stems and leaves. This shift was not observed in nonsilicon-supplemented plants. Prolonged oviposition triggered pigmentation in the basal cells of type I glandular trichomes on the stems of silicon-supplemented plants. …

Know Where You Go: Infestation Dynamics And Potential Distribution Of Two Bed Bug Species (Hemiptera: Cimicidae) In Africa, Dennis M. Mbuta, Bonoukpoè M. Sokame, Fathiya M. Khamis, Komivi S. Akutse

All Peer-Reviewed Publications

Bed bugs (Hemiptera: Cimicidae) are blood-feeding insects closely linked with humans and animals, causing discomfort, and posing potential threats as disease vectors. This study focuses on Cimex lectularius (common bed bug) and Cimex hemipterus (tropical bed bug), the two key species identified in Africa. Cimex lectularius infests human habitats, while C. hemipterus, more common in Africa, infests diverse habitats, including bat colonies. In our study, we investigated the infestation dynamics and distribution of bed bugs in Africa, when considering climate, habitat, and host availability using system dynamics and ecological niche modelling techniques. System dynamics modelling analyses in Kenya revealed varied …

Insulin-Like Growth Factor 2 As A Driving Force For Exponential Expansion And Differentiation Of The Neonatal Thymus, Seung Woo Kang, Bryan R Helm, Yu Wang, Shiyun Xiao, Wen Zhang, Anusha Vasudev, Ken S Lau, Qi Liu, Ellen R Richie, Laura P Hale, Nancy R Manley

Faculty, Staff and Student Publications

Like all organs, the thymus grows in size and function rapidly during development, but this growth comes to a halt after birth. However, the molecular mechanisms behind such a transition in the thymus remain obscure. Using single-cell RNA sequencing (scRNA-seq) of the murine thymic stroma, we identified that major transcriptomic changes occur in the endothelium and mesenchyme across the transition to homeostasis. Differentially expressed gene and intercellular network analyses of temporally resolved scRNA-seq data revealed fibroblast-derived insulin-like growth factor 2 (IGF2) as a candidate driving neonatal thymic expansion. We demonstrated that IGF2 activity promotes a cortical thymic epithelial cell-specific proliferation …

Characterization Of A Time-Resolved, Real-Time Scintillation Dosimetry System For Ultra-High Dose-Rate Radiation Therapy Applications, Alexander Baikalov, Daline Tho, Kevin Liu, Stefan Bartzsch, Sam Beddar, Emil Schüler

Faculty, Staff and Student Publications

Purpose: Scintillation dosimetry has promising qualities for ultra-high-dose-rate (UHDR) radiation therapy (RT), but no system has shown compatibility with mean dose rates (DR¯) above 100 Gy/s and doses per pulse (Dp) exceeding 1.5 Gy typical of UHDR (FLASH)-RT. The aim of this study was to characterize a novel scintillation dosimetry system with the potential of accommodating UHDRs.

Methods and materials: We undertook a thorough dosimetric characterization of the system on an UHDR electron beamline. The system's response as a function of dose, DR¯, Dp, and the pulse dose-rate (DRp) was investigated, as was the system's dose sensitivity (signal per unit …

Defining A 'Cells To Society' Research Framework For Appendiceal Tumours, Andreana N Holowatyj, Michael J Overman, Konstantinos I Votanopoulos, Andrew M Lowy, Patrick Wagner, Mary K Washington, Cathy Eng, Wai Chin Foo, Richard M Goldberg, Mojgan Hosseini, Kamran Idrees, Douglas B Johnson, Ardaman Shergill, Erin Ward, Nicholas C Zachos, Deborah Shelton

Faculty, Staff and Student Publications

Tumours of the appendix — a vestigial digestive organ attached to the colon — are rare. Although we estimate that around 3,000 new appendiceal cancer cases are diagnosed annually in the USA, the challenges of accurately diagnosing and identifying this tumour type suggest that this number may underestimate true population incidence. In the current absence of disease-specific screening and diagnostic imaging modalities, or well-established risk factors, the incidental discovery of appendix tumours is often prompted by acute presentations mimicking appendicitis or when the tumour has already spread into the abdominal cavity — wherein the potential misclassification of appendiceal tumours as …

Streamlining Field Note Analysis: Leveraging Gpt For Further Insights, Saríah López-Fierro, Umar Shehzad, Alireza (Sina) Zandi, Jody Clarke-Midura, Mimi Recker

Publications

As an integral part of qualitative research inquiry, field notes provide important data from researchers embedded in research sites. However, field notes can vary significantly, influenced by the researchers' immersion in the field, prior knowledge, beliefs, interests, and perspectives. As consequence, their interpretation presents significant challenges. This study offers a preliminary investigation into the potential of using large language models to assist researchers with the analysis and interpretation of field notes data. Our methodology consisted of two phases. First, a researcher deductively coded field notes of six classroom implementations of a novel elementary-level mathematics curriculum. In the second phase, we …

Mere Wudu Legend, Alexis L. Campos, Ixchel Mireles, Bryon Haynes, David Kamal, Zachariah Gonzalez

Team - Mere Wudu - Documents

A story written in Ietic that discusses climate change and how it has impacted our society and land. An English version, Ietic version and a version written in our own alphabet is provided

Mere Wudu Semantics And Pragmatics, Alexis L. Campos, Ixchel Mireles, Bryon Haynes, David Kamal, Zachariah Gonzalez

Team - Mere Wudu - Documents

The Semantics and Pragmatics of our language. Descriptions and explanations of our religious and cultural values and beliefs.

Theshrahk Thwath Semantics And Pragmatics, Mary Arnolds, Sofia Farias, Alexandra Renteria, Nicholas Denmark

Team - Theshrahk Thwath - Documents

This document contains some semantic fields and pragmatic conventions of the Theshalshe language, including apologies, story openings, and conversational turn-taking.

Theshrahk Thwath Swadesh List, Mary Arnolds, Sofia Farias, Alexandra Renteria, Nicholas Denmark

Team - Theshrahk Thwath - Documents

This document contains some the lexicon, verb conjugation patters, plural structures, and nominalization pattern of Theshalshe. The lexicon entries are presented in Theshalshe, romanized form, and a pronunciation guide using the IPA.

The Impact Of Ballet Techniques On Singing Performers, Julie H. Welch

Theses and Dissertations

Singing performers are tasked to being a multifaceted artist using their acting and even dance skills in a performance. Voice teachers have long incorporated physical activity into training, but traditional ballet techniques—such as core tension and neck elongation—can contradict healthy singing practices. Given ballet’s deep historical connection to opera and stage performance, this study aims to examine whether integrating ballet into vocal training enhances or hinders a singer’s technique and overall performance. This investigation surveyed forty subjects who identified as teachers, singing performers, or students earning a performance degree and interviewing select subjects for further information; results will be discussed.

Transcrite Par L'Auteur: Analyzing And Performing The Piano-Vocal Scores Of Maurice Ravel's Operas, Jordan Knapp

Theses and Dissertations

The two operas of Maurice Ravel, L’heure espagnole and L’enfant et les sortilèges, are, like most of the composer’s works, known for their innovative orchestrations and instrumental flourishes. However, the piano-vocal scores of the operas have their own unique qualities worthy of study. With the piano writing at times fiendishly difficult—standing toe-to-toe with Ravel’s solo piano music—the score demands simplification, particularly for less experienced performers serving as accompanist or rehearsal pianist for these works. Many sections of the music are impractical or even impossible for a single pianist to perform, but this study offers alternate solutions and simplifications for pianists …

Reclaiming The Body: Gender Politics And Embodied Meaning In Piano Performance And Pedagogy, Rachel Misheff

Theses and Dissertations

This study examines the impact of the mind-body duality and its gendered metaphor on the lived experiences of historical and contemporary female pianists. Specifically, it explores how the principles of mind-body dualism have constructed gendered practices in piano performance and pedagogy that have both marginalized female pianists and engendered distinct embodied relationships to music. The study draws upon research from other disciplines, such as phenomenology, theories of embodiment, feminist theory, psychoanalysis, and Embodied Music Cognition, to examine how these gendered musical norms resulting from mind-body dualism functioned as forces of social inscription. This research, therefore, suggests that the body’s lived …

Activation Of Basal Forebrain Afferents Following Systemic Inflammation, Alexis Morgan Blas

Theses and Dissertations

Sepsis is a large-scale immune response typically due to an imbalance of pro- and anti-inflammatory responses due to some type of infection or insult. Around 1.7 million adults in the United States will develop it each year, making it the leading cause of increased morbidity and mortality in hospitals. Sepsis can lead to many different symptoms, one of which is delirium. Delirium is a mental state of confusion and disorientation and involves delusions, hallucinations, memory issues, and most commonly inattention. Delirium is more prevalent in older individuals which leads to further complications and a higher likelihood of development of long-term …

A Novel Geometric Modeling Kernel For Automated Fiber Placement, Rowen Burney

Theses and Dissertations

Automated Fiber Placement (AFP) is a key manufacturing technique for producing high-performance composite structures, yet existing geometric modeling frameworks lack the specialized functionality required for efficient toolpath planning and laminate optimization. This work presents Knots, a Geometric Modeling Kernel (GMK) developed specifically to address these limitations by providing a unified geometric foundation tailored for AFP. Unlike general-purpose Computer Aided Design (CAD) libraries, Knots is optimized for AFP, offering specialized geometric operations that streamline the transition from design to manufacturing. It directly manages the loading and computation of geometric data, ensuring structured laminate generation while supporting automation and scripting for improved …

Estimation And Analysis Of The Cost Function Of The Food Industries In Iraq, Mustafa Qopeis Qasim, Salah Mahdi Abbas Al-Birmani

Journal of Economics and Administrative Sciences

The paper analyses the production costs of Iraq's food industry and tries to establish its optimum production level. Declining contribution to GDP resulting from high production costs, competition brought about by imported products, and economic instability has been showed by the study in focusing on the industry. The paper employs econometric analysis through EViews-10 to estimate cost functions across different industrial scales (Small, Medium, and Large) for the period between the years 2004 and 2022. Findings reveal that the optimal production efficiency has not been attained so far for the food industry of Iraq. It is suffering from a high …

Delirium And Derangement: Futurities Of Climatic And Islandic Relationality In Philippine Artistic Practice, Isa Lacuna

Akda: The Asian Journal of Literature, Culture, Performance

The Philippines as locus of both specific experience and shared sympathy with regard to climate change allows for an investigation of the complex factors that describe a realm of experience unique to this present age: catastrophic weather in both its scorching and diluvian iterations. In this paper, I argue that the atmospheric delusions in the artistic practices of Mark Orozco Justiniani’s Arkipelago and the Vargas Museum’s Fever Dream point to a more expansive relationality with climate that forces us to re-evaluate precisely what ecocritical scholars have called the derangements of everyday modern life. The experience of exceptional heat and rain, …

Preliminaries And Editor's Introduction, Dinah Tapia Roma

Akda: The Asian Journal of Literature, Culture, Performance

No abstract provided.

Redbird Scholar, Vol. 10, No. 2 (Spring 2025), Illinois State University, Office Of The Vice President For Research And Graduate Studies

Redbird Scholar

No abstract provided.

“Plenty Of Heart And Plenty Of Hope”: An Analysis Of Social And Historical Implications In Post-Wwii Western Musical Films, Katelyn N. Lister

Selected Honors Theses

World War II had a profound and significant impact on American life and culture. Hollywood and film production was one area that was notably different after the war with themes and settings that promoted patriotism and American values being seen more frequently. Film lends itself to analysis due to its recorded and preserved nature that allows audiences today to view the same thing that audiences in the early 1950s were seeing, albeit with a different worldview. Western movies made in the late 1940s and early 1950s perfectly encapsulate the feelings of most Americans during the postwar period. Additionally, a new …

Targeting Malaria Using Rts,S/As01 Liposome Based Therapy In Combination With Cryptolepis Sanguinolenta, Michelle Villacorta Del Castillo

Selected Honors Theses

Malaria has shown to be a threatening disease to half of the population of the world, with currently 241 million cases reported. Malaria treatments have yet to be completely effective due to their ability and resistance to antimalarial drugs Plasmodium falciparum has developed, making it challenging to help treat this disease. RTS, S/AS01 has been shown to act on the pre-erythrocytic stage of malaria, targeting the circumsporozoite protein of Plasmodium falciparum expressed by the malaria parasite during this stage. At the same time, Cryptolepsis Sanguinolenta has been shown to have 90% inhibition of Plasmodium falciparum K1 growth. They have both …

An Examination Of Karl Barth’S Critique Of Natural Theology: The Epistemological Shift Post-Salvation, Luke D. Pelkey

Selected Honors Theses

This thesis reexamines Karl Barth’s rejection of natural theology, specifically if his Christocentric framework allows for a limited, post-salvific engagement with natural revelation. While Barth is adamant in his denial of the source of knowledge of God being found solely through reason, logic, or nature, this thesis argues that Barth does not reject the possibility of natural revelation but rejects its accessibility. But, due to the effects of salvation on not just the soul but the whole of one’s being, the mind is also renewed, allowing for the noetic effects of sin to be overcome. Drawing from Church Dogmatics I/1, …