Digital Commons Network^™

Cross-Tissue Coordination Between Slc Nucleoside Transporters Regulates Reproduction In Caenorhabditis Elegans, Youchen Guan, Yong Yu, Shihong M Gao, Lang Ding, Qian Zhao, Meng C Wang

Faculty, Staff and Students Publications

Metabolism is fundamental to organism physiology and pathology. From the intricate network of metabolic reactions, diverse chemical molecules, collectively termed metabolites, are produced. In multicellular organisms, metabolite communication between different tissues is vital for maintaining homeostasis and adaptation. However, the molecular mechanisms mediating these metabolite communications remain poorly understood. Here, we focus on nucleosides and nucleotides, essential metabolites involved in multiple cellular processes, and report the pivotal role of the SLC29A family of transporters in mediating nucleoside coordination between the soma and the germline. Through genetic analysis, we discovered that two Caenorhabditis elegans homologs of SLC29A transporters, Equilibrative Nucleoside Transporter …

Recommendations For Design, Execution, And Reporting Of Studies On Experimental Thoracic Aortopathy In Preclinical Models, Alan Daugherty, Dianna M Milewicz, David A Dichek, Ketan B Ghaghada, Jay D Humphrey, Scott A Lemaire, Yanming Li, Ziad Mallat, Yvan Saeys, Hisashi Sawada, Ying H Shen, Toru Suzuki, Zhen Zhou

Faculty, Staff and Students Publications

There is a recent dramatic increase in research on thoracic aortic diseases that includes aneurysms, dissections, and rupture. Experimental studies predominantly use mice in which aortopathy is induced by chemical interventions, genetic manipulations, or both. Many parameters should be deliberated in experimental design in concert with multiple considerations when providing dimensional data and characterization of aortic tissues. The purpose of this review is to provide recommendations on guidance in (1) the selection of a mouse model and experimental conditions for the study, (2) parameters for standardizing detection and measurements of aortic diseases, (3) meaningful interpretation of characteristics of diseased aortic …

Pediatric Predictive Artificial Intelligence Implemented In Clinical Practice From 2010 To 2021: A Systematic Review, Swaminathan Kandaswamy, Lindsey A Knake, Adam C Dziorny, Sean M Hernandez, Allison B Mccoy, Lauren M Hess, Evan Orenstein, Mia S White, Eric S Kirkendall, Matthew J Molloy, Philip A Hagedorn, Naveen Muthu, Avinash Murugan, Jonathan M Beus, Mark Mai, Brooke Luo, Juan D Chaparro

Faculty, Staff and Students Publications

To review pediatric artificial intelligence (AI) implementation studies from 2010 to 2021 and analyze reported performance measures.We searched PubMed/Medline, Embase CINHAL, Cochrane Library CENTRAL, IEEE, and Web of Science with controlled vocabulary. Inclusion criteria: AI intervention in a pediatric clinical setting that learns from data (i.e., data-driven, as opposed to rule-based) and takes actions to make patient-specific recommendations; published between 01/2010 and 10/2021; must have agency (AI must provide guidance that affects clinical care, not merely running in the background). We extracted study characteristics, target users, implementation setting, time span, and performance measures.Of 126 articles reviewed as full text, 17 …

Temporal Dynamics Of Bmp/Nodal Ratio Drive Tissue-Specific Gastrulation Morphogenesis, Alyssa A Emig, Megan Hansen, Sandra Grimm, Cristian Coarfa, Nathan D Lord, Margot Kossmann Williams

Faculty, Staff and Students Publications

Anteroposterior elongation of the vertebrate body plan is driven by convergence and extension (C&E) gastrulation movements in both the mesoderm and neuroectoderm, but how or whether molecular regulation of C&E differs between tissues remains an open question. Using a zebrafish explant model of anteroposterior axis extension, we show that C&E of the neuroectoderm and mesoderm can be uncoupled ex vivo, and that morphogenesis of individual tissues results from distinct morphogen signaling dynamics. Using precise temporal manipulation of BMP and Nodal signaling, we identify a critical developmental window during which high or low BMP/Nodal ratios induce neuroectoderm- or mesoderm-driven C&E, respectively. …

Faith Formation And Discipling For Metamoderns, Kenley Hall

Journal of Adventist Youth and Young Adult Ministries

What does the future of faith formation and discipling look like for “Metamoderns” with their cultural logic of toggling, which presents both a challenge and opportunity to the corporate and the local church? The unique cultural logic of Metamodernism has the potential not to weaken faith but rather create a deeper faith than that seen in previous generations and will suggest how the church can create a space for that faith to develop. Metamodernistic spirituality is still in its nascent formation. Depending on how the church, corporately and locally, responds on both levels will either lead Metamoderns into a deeper …

Evaluating The Effects Of Co₂ And Uv-B On Sporobolus Virginicus (L.) Kunth Growth Under Open Top Chamber: A Comparison Of Silicon Nanoparticle-Treated And Untreated Plants, Suhaila Humaid Ablooshi

Theses

The study focused at how silicon nanoparticles (SiNPs; 50 mg/L) affected the growth, photosynthetic efficiency, and biochemical responses of the salt-tolerant halophyte Sporobolus virginicus in four different environments. They are control, high CO₂, UV-B radiation, and a mix of high CO₂ and UV-B. Plants that were treated with SiNPs showed big changes in their shape, such as more biomass, bigger leaf area, and better root systems in all conditions. The use of combined stress treatments caused a big increase in the levels of chlorophyll a, chlorophyll b, total chlorophyll, and carotenoids. As a result, that the plants were better at …

A Study Of The Impact Of Balancing, Geometric Transformation, Generative Networks, And Roi Techniques In Eye Diseases Classification, Sghaira Hareb Alnuaimi

Theses

Automatic detection of ocular diseases helps medical professionals efficiently identify eye disorders, reduce diagnostic errors, and accelerate diagnoses to prevent blindness. Deep learning has been successfully utilized in various fields, including medical image classification. However, in spite of these advancements, challenges remain in ocular disease classification.

The objective of this work is to address these challenges using data processing, data augmentation in combination with Region of Interest (ROI) techniques. Medical datasets often suffer from scarcity, imbalance, and low-quality images, leading to inaccurate classification. To mitigate these issues, we utilize the ODIR dataset, which contains 7,000 labelled training images for both …

Computational And Functional Prioritization Identifies Genes That Rescue Behavior And Reduce Tau Protein In Fly And Human Cell Models Of Alzheimer Disease, Morgan C Stephens, Jiayang Li, Megan Mair, Justin Moore, Katy Zhu, Akash Tarkunde, Bismark Amoh, Alma M Perez, Arya Bhakare, Fangfei Guo, Joshua M Shulman, Ismael Al-Ramahi, Juan Botas

Faculty, Staff and Students Publications

Genome-wide association studies (GWASs) in Alzheimer disease (AD) have uncovered over 70 loci significantly associated with AD risk, but identifying the true causal gene(s) at these loci requires systematic functional validation that is rarely performed due to limitations of time and cost. Here, we integrate transcriptome-wide association study (TWAS) with colocalization analysis, fine-mapping, and additional annotation of AD GWAS variants to identify 123 genes at known and suggestive AD risk loci. A comparison with human AD brain transcriptome data confirmed that many of these candidate genes are dysregulated in human AD and correlate with neuropathology. We then tested all available …

Random Processes With High Variance Produce Scale Free Networks, Josh Johnston

Boise State University Theses and Dissertations

The degree distribution of a real world network --- the number of links per node --- often follows a power law, so some hubs have many more links than traditional graph generation methods predict. For years, preferential attachment and growth have been the proposed mechanisms leading to these scale free networks, exemplified by the Barabási–Albert model. This dissertation provides an alternative model using a randomly stopped linking process, showing that mixtures of geometric distributions can lead to power laws, an intuition suggested by the Central Limit Theorem for distributions with infinite variance. Having a collection of Bernoulli trials with high …

A Multi-Tiered Approach To Improving Vaccination: Adjuvanticity, Alternate Routes Of Delivery, And Science Communication, Haley Agnes Bridgewater

Boise State University Theses and Dissertations

Vaccines have been used to prevent infectious disease for over 200 years. While they are an incredible way to prevent loss of life, they can be improved upon. Researchers around the globe are working to improve the immune response and ultimately the protection provided by existing and new vaccines. In this dissertation, I investigate three ways to improve vaccine immune responses: using an adjuvant, using a prime-boost intramammary delivery route in cows, and using microneedle delivery route. Cholera toxin (CT) is a bacterial toxin that has a non-toxic B subunit (CTB) used as a vaccine adjuvant. However, little is known …

Characterizing Successional Dynamics And Host Impacts On The Big Sagebrush Leaf Microbiome, Jacob A. Heil

Boise State University Theses and Dissertations

The leaf microbiome contributes to the functioning of Earth’s ecosystems through interactions with host plants, modifying their health, for better or for worse. The leaf microbiome contains bacteria, fungi, and other microorganisms that interact with each other and are subject to the processes governing community assembly. Microbial community assembly on the leaf is influenced by host plant characteristics, interactions between the different community members, the selective and dispersal-mediated effects of the weather, and time. To study the effects of a leaf microbiome on its host plant it is first important to characterize it; observing the species present and how they …

"I Feel An 'I'M Not Sure' Feeling": Young Children's Perspectives During Outdoor Risky Play, Erin Tanzer

Boise State University Theses and Dissertations

Young children’s outdoor risky play is an intriguing and challenging phenomenon in early childhood care and education settings (ECCE). While recent research on risky play conveys the numerous developmental benefits, types of play children engage in, environmental affordances, and approaches to risk assessment, minimal research includes children’s perspectives about their risky play experiences. This phenomenological case study explores preschool children’s experience and what they feel and wonder about during risky play in a setting where risky play is effectively supported. Data were collected using interactive observation and interviews and analyzed using thematic analysis. Children described feeling “good” and “scared” during …

Examining Stable Isotope Variation Of Herbivores In South Luangwa Valley In The Context Of Anthropogenic Influences, Taylor Hubbard

Graduate Theses and Dissertations

Stable isotopes are an effective tool for inferring mammalian behavior. Though there are multiple factors that can influence mammalian diets, anthropogenic influence is one that is often overlooked. For example, it is important to consider how wildlife living in areas where there are frequent, documented human-wildlife interactions will modify behavior. National Parks (NPs) are a great example of this because of the common misconception that since there are protections in place, that means it is devoid of anthropogenic influence. South Luangwa National Park contradicts this misconception. Though there are protections for wildlife in place within the park, it is unfenced …

A Comprehensive Review Of Carbon Sequestration And Its Assessment Techniques Using Remote Sensing And Geospatial Methods, Imen Ben Salem

All Works

Global warming has elevated carbon sequestration as a critical strategy for mitigating climate change, while enhancing sustainability in productivity. Agricultural land use systems contribute substantially to CO2 emissions due to crop residues, shifting cultivation practices, low-biomass crops, land degradation, and deforestation. The significant rise in CO2 emissions over the past thirty years is associated with burning fossil fuels, leading to substantial environmental changes, including global warming. Remote sensing (RS) and Geographic Information Systems (GIS) are advanced geospatial technologies that facilitate the rapid evaluation of terrestrial carbon stock over extensive regions. An integrated RS-GIS approach for carbon stock estimation and precision …

Predictors Of Waste Management Behaviours In Coastal Communities In Indonesia: The Role Of Community Attachment And Environmental Concern, Ana Voronkova, Kayleigh Wyles, Nur Syamsiyah, Sudarso, Eddy Soedjono, Lesley Henderson, Wesley Schultz, Susan Jobling, Sabine Pahl

School of Psychology

The global challenge of marine plastic pollution requires systemic change in our relationship with plastic. Thecurrent linear plastic economy must transition to a sustainable circular model, but is hindered by behaviouralchange difficulties, particularly in coastal regions facing resource limitations and a lack of research attention.This study investigates waste management (WM) behaviours in Java and Bali, Indonesia, through a householdsurvey (N = 506). By examining the roles of community attachment and environmental concern in WM behaviours, we contribute to the theoretical understanding of these concepts within a novel context. Our findingsreveal that community attachment and environmental concern predict WM behaviours, yet …

Kinetic Growth Rate Analysis Of Coelastrella Sp. In Aquaculture Wastewater., Rob Skarvan

Master of Engineering Theses

The demand for sustainable food and energy production continues to rapidly rise. Utilizing aquaculture wastewater as microalgae growth medium is a potential opportunity for nutrient recycling and industrial symbiosis, but more research is required to understand how best to design and scale-up a dual-purpose facility. This study investigates the growth of Coelastrella sp. in aquaculture wastewater compared to industry-standard growth medium BG-11 and modified tap water as controls. Though cell size and pigment density varied throughout media, aquaculture wastewater performed very comparably to BG-11 as a microalgae culture broth.

The Monod equation can model Coelastrella sp. growth based …

Minimizing Secondary Spinal Cord Injuries With Hypertonic Saline., Francisco A. Cortez-Thomas

Master of Engineering Theses

Spinal cord injury (SCI) disrupts white matter, causing periaxonal swelling, axonal degeneration, and impaired function. To examine vascular edema’s role, we developed a 3Dprinted dual-compartment imaging chamber to mimic and manipulate interstitial and vascular fluid dynamics in real time. We hypothesized that hypertonic saline (HTS) in the "vascular" chamber would osmotically shift fluid from the periaxonal space and preserve myelinated fibers after SCI. Using two-photon excitation microscopy, we imaged myelin and axons ex vivo in Thy1^YFP+ transgenic mice following C5 contusive SCI and assessed three clinically relevant HTS concentrations versus normal saline for their effectiveness in mitigating periaxonal swelling …

International Rice Outlook: International Rice Baseline Projections 2024–2034, A. Durand-Morat, W. Mulimbi

AAES Research Reports and Research Bulletins

• Global rice consumption is projected to exceed global rice production for most of the coming decade, with stocks playing a crucial role in balancing the global market over the projected period.

• The projected growth in production is almost exclusively due to productivity gains.

• The projected global rice consumption is growing, driven mainly by population growth. However, the average global per capita rice consumption is estimated to increase slowly in the coming decade due to a regain in per capita consumption in Asia, the largest rice-consuming region worldwide.

• The international prices of long-grain and medium-grain rice are …

Selecting Green Wall Adoption Best Solutions Using Optimization: Addressing Barriers And Maximizing Benefits, Samar Nadeem

Theses and Dissertations

This research explores the potential of green walls as a sustainable solution to mitigate urban challenges and align with global climate change objectives. Despite their ecological and social benefits, green wall implementation faces significant barriers, hindering their adoption. Consequently, this study aims to develop a comprehensive framework to identify the obstacles, propose feasible solutions, and provide actionable strategies for promoting green walls. This framework incorporates an optimization model specifically designed for government-led solutions, evaluating their feasibility based on administrative feasibility, community acceptance, technical feasibility, industrial acceptance, and long-term adoption potential. By quantifying and prioritizing solutions based on their cost, feasibility, …

Dental Microwear Of Miocene Primates From The Carpathian Basin, Rudabánya, Hungary, Anna K. Wilcox

Biological Sciences Undergraduate Honors Theses

This study reconstructs and compares the dietary habits of the late Miocene primates Anapithecus hernyaki and Rudapithecus hungaricus by analyzing dental microwear patterns on fossilized teeth recovered from Rudabánya, Hungary. Previous research suggested that these sympatric species were both primarily frugivores but were unable to separate them by diet. However, earlier studies were limited by smaller sample sizes and less advanced methodologies. This study used an expanded sample and modern microwear texture analysis techniques to compare molar and incisor microwear patterns between the two species. Results revealed that Rudapithecus molars exhibited higher complexity compared to Anapithecus molar complexity, suggesting a …

Assessment Of Nitrogen Source Utilization During Nitrogen Fixation And Nitrogenase Regulation By Methanosarcina Acetivorans, Avery Carter

Biological Sciences Undergraduate Honors Theses

Nitrogen is a crucial element in biomolecules such as proteins and DNA, essential for all cellular life. Biological nitrogen fixation, a process utilized by certain bacteria and archaea, reduces dinitrogen (N₂) to ammonia (NH₃), enabling growth in the absence of fixed nitrogen sources like NH₃. This process is driven by the metalloenzyme nitrogenase, which catalyzes the reaction: N₂ + 16ATP + 8e⁻ + 8H⁺ → 2NH₃ + H₂ + 16ADP + 16Pi. Due to its high energy demand, nitrogenase production and activity are tightly regulated. Among archaea, nitrogenase is found exclusively in methanogens, where its regulation remains poorly understood. We …

The Effects Of Daily Beef Consumption On Sleep, Mood, And Wellbeing In Postmenopausal Women, Caroline M. Coughlin

Biological Sciences Undergraduate Honors Theses

Menopause is often accompanied by changes in sleep, mood, and overall well-being, partly due to hormonal shifts and loss of muscle mass. Protein intake, especially from nutrient-rich sources like beef, may help address these changes, but research in postmenopausal women remains limited. This study explored how daily beef consumption, as part of a higher-protein diet, affected sleep quality, mood, and well-being over eight weeks. Ten active postmenopausal women were randomly assigned to either a control group (meeting standard protein recommendations) or a treatment group consuming twice that amount, including one serving of lean beef per day. Sleep was measured using …

An Analysis Of The Effects Of Embedded Instruction And Item Quality On Activity Selection, Julianne Isabella Fernandez

Theses and Dissertations

Naturalistic teaching strategies, such as embedded instruction, have been used to effectively teach a variety of skills to individuals diagnosed with ASD and other developmental disabilities. However, the effect of embedding instructions on a child’s play preferences is unknown. The goal of this study is to evaluate whether response allocation is dependent on frequency of demands or quality of items available during preferred activities. We used a concurrent operants arrangement in which a room was divided into two sides and various toys were placed in each with embedded demands available in one side. In Experiment 1, researchers evaluated the time …

Early Breast Cancer Detection With Ultrasound Data Using Nmf, Rutvi Khamar

Theses and Dissertations

Early detection of breast cancer significantly influences patient outcomes. Dynamic Contrast-Enhanced Ultrasound (DCE-US) has shown promise in early detection by visualizing tumor vascularity and perfusion dynamics in real-time. This study evaluates the efficacy of DCE-US in distinguishing four stages of cancer progression: normal, hyperplasia, ductal carcinoma in situ (DCIS), and invasive cancer, using a transgenic mouse model that mimics human breast cancer. Ultrasound burst pulses, while commonly used to remove unbound contrast agents, can potentially damage human tissues. Using the pre-pulse data helps mitigate this risk, ensuring safer and more reliable measurements. A VEGFR2-targeted microbubble contrast agent was injected, and …

Evaluating A Video Modeling Approach To Teach Shelter Volunteers How To Interact With Dogs In The Shelter, Sean Michael Will

Theses and Dissertations

Well-trained volunteers are required to help meet the daily needs of dogs waiting to be adopted in animal shelters and to find new homes for them. Inadequate volunteer training leads to mismanagement and attrition of volunteers who are essential to helping shelter dogs get adopted. However, animal shelters often lack access to the resources and funds required to provide adequate training for volunteers. Using a nonconcurrent multiple baseline design, this study evaluated a cost-effective program consisting of video modeling with voiceover instruction, on-screen text, examples, and non-examples that instructed volunteers to interact with the dogs in a specific manner to …

Severe Acute Malnutrtion Among Children Under Five In South Sudan, Rhoda Elia Iburu Kenyi

Capstone Experience: Master of Public Health

Severe acute malnutrition (SAM) is a life-threatening condition characterized by severe wasting. The World Health Organization defines SAM as a low weight-for-height Z-score (WHZ) less than -3 standard deviation (SD) from the median growth standard or the presence of edema of both feet and/or mid-upper arm circumference (MUAC) less than 115mm. SAM is a significant public health concern affecting children under five in developing countries, with South Sudan being one of the most severely affected regions. Persistent food insecurity, weak healthcare systems, and ongoing conflict contribute to the high SAM prevalence in the region, where political, religious, and social divisions, …

Focus Group Study Of Racial Disparities And The Effects Of Parental Marijuana Use On Youth Marijuana Use, Avina K. Mahroke

Capstone Experience: Master of Public Health

Marijuana has become one of the most used drugs in the United States. There has been an increase in use among both adults and youth during the past several years. Public health interventions are needed to address marijuana use because of its detrimental effects on youth well-being. Research shows that marijuana can lead to problems with memory, learning, attention, and even depression among youth. Furthermore, marijuana exposure in-utero can lead to developmental issues and problems with other organs such as the lungs. Youth are influenced to start using drugs, like marijuana, for numerous reasons, and parents are one of those …

Unbridled Healing: Identifying The Barriers Of Equine-Assisted Therapy, Sally A. Hamm

Human Development and Family Sciences Undergraduate Honors Theses

Despite the documented benefits of equine-assisted therapy (EAT) for mental health conditions, this complementary approach remains underutilized. This qualitative study investigated barriers preventing wider EAT implementation by examining challenges faced by clients, facilities, and volunteers. Data collected through open-ended surveys from 33 participants and the researcher's autoethnographic observations revealed eight common barriers: Accessibility (48 mentions), Money (43), Time (30), Awareness (23), Physical Factors (13), Relationships (13), Risk (13), and Weather (7). Clients identified financial constraints as their primary barrier, particularly insurance limitations. Facilitators struggled most with accessibility challenges, including lack of resources, trained staff, suitable horses, and appropriate facilities. Volunteers …

Parental Expectations On Pediatric Care For Children, Brenan Cash

Human Development and Family Sciences Undergraduate Honors Theses

Childhood pediatrics is a major factor for a full and healthy childhood for all children from adolescence to adulthood. However, the physical health aspect has been the main focus through most primary care clinics and hardly focuses on the mental health side. Mental health issues which involve anxiety, depression, and post-traumatic stress are more prominent than they have ever been, as up to 30% of children have experienced mental health issues such as posttraumatic stress disorder, especially in recent pandemic years (Meherali et al., 2021). This study employed a non-experimental, quantitative analysis utilizing online close-ended survey questions. The type of …

The Weaponization Of Medicine In Arkansas Prison Farms, 1960s-1970s, Grace E. Marr

History Undergraduate Honors Theses

The Arkansas State Penitentiary provides a case study for medical care in prisons during a transformational period. Isolation and state non-involvement in Arkansas allowed the creation of an independent culture in which harrowing abuses flourished. Medical providers could be prisoners themselves, operating the hospital and blood bank creating a complicated hierarchy. By examining medical provisions at the Cummins and Tucker Prison Farms during the 1960s to 1970s, this thesis reveals a system where the lines between treatment and torture and medical practitioner and imprisoned were blurred.