Digital Commons Network^™

The Geopolitics Of Digital Regulation, Aziz Z. Huq

University of Chicago Law Review

Contemporary regulation of new digital technologies by nation-states unfolds under a darkening shadow of geopolitical competition. The United States government operates simultaneously in a domestic political environment dominated by oligopolistic firms competing to expand, and in an international political environment wherein it competes against other sovereign nations by cultivating and deploying digital technological capacities for geostrategic economic and military ends. Thanks to the ensuing burst of crosscutting pressures, both national and supranational regulation can take on surprisingly reticulated, even baroque or perverse, forms.

Three recent monographs offer illuminating and complementary maps of these geopolitical conflicts and the national responses to …

Untethered And Unraveled: Isolated Motherhood In The Liminal Stage, Ashton K. Wronikowski

All Theses

In examining Kate Chopin’s The Awakening alongside anthropologic theories of liminality, this paper examines the becoming women traverse as they transition between various social roles: girl, woman, mother. Edna is a maternal character attempting to unweave herself from her roles as mother and wife, and she finds this desire to go backwards to the freedom she experienced as a girl is proven to be impossible. The unmooring of her psyche and her subsequent suicide is indicative of a failure, not of her own accord, but in the social preparation and support she receives within her new identity. Social anthropologists further …

The Great Animal Rights Debate: From The Past Into The Present, Dayna Wiley

Celebrating Scholarship and Creativity Day (2018-)

Animal rights are not a novel concept, and everyone has their own beliefs about where animals should fit into the hierarchy of life. Not so different from today, a debate occurred in the ancient world between the Stoics, represented by Aristotle, and Plutarch, with each questioning whether animals are capable of rational thought or feelings, and therefore whether they are deserving of justice. There is much to learn from the ancient world about the modern debate on animal rights, and there is a striking comparison between this ancient debate and the modern questions of animal rights. But how similar are …

Reading The Minoan "Sacral Knot", Rylie Owen

Celebrating Scholarship and Creativity Day (2018-)

The sacral knot, a term first coined by Sir Arthur Evans, is an iconic symbol in Minoan iconography, but there is surprisingly little information about it. Various interpretations have been suggested regarding the meaning of this knot, the most popular and well-known being a religious function.There is no doubt that the so-called "sacral knot” had an important meaning in Bronze Age Greece, with a number of depictions showing the knot alongside other significant symbols, such as bulls, figure-of-eight shields, and lions. However, the knot also appears to function as a symbol on its own. This analysis draws from a compilation …

Alpha-Smooth Muscle Actin-Expressing Dermal Sheath Cells Are A Major Cellular Contributor To Heterotopic Subcutaneous Ossifications In A Mouse Model Of Albright Hereditary Osteodystrophy., Patrick Mcmullan, Peter Maye, Sierra H Root, Qingfen Yang, Sarah Edie, David Rowe, Ivo Kalajzic, Emily L Germain-Lee

Faculty Research 2025

Heterotopic ossifications (HOs) are the pathologic process by which bone inappropriately forms outside of the skeletal system. Despite HOs being a persistent clinical problem in the general population, there are no definitive strategies for their prevention and treatment due to a limited understanding of the cellular and molecular mechanisms contributing to lesion development. One disease in which the development of heterotopic subcutaneous ossifications (SCOs) leads to morbidity is Albright hereditary osteodystrophy (AHO). Albright hereditary osteodystrophy is caused by heterozygous inactivation of GNAS, the gene that encodes the α-stimulatory subunit (Gαs ) of G proteins. Previously, we had shown using our …

Complete Sequencing Of Ape Genomes., Dongahn Yoo, Arang Rhie, Prajna Hebbar, Francesca Antonacci, Glennis A Logsdon, Steven J Solar, Dmitry Antipov, Brandon D Pickett, Yana Safonova, Francesco Montinaro, Yanting Luo, Joanna Malukiewicz, Jessica M Storer, Jiadong Lin, Abigail N Sequeira, Riley J Mangan, Glenn Hickey, Graciela Monfort Anez, Parithi Balachandran, Anton Bankevich, Christine R Beck, Arjun Biddanda, Matthew Borchers, Gerard G Bouffard, Emry Brannan, Shelise Y Brooks, Lucia Carbone, Laura Carrel, Agnes P Chan, Juyun Crawford, Mark Diekhans, Eric Engelbrecht, Cedric Feschotte, Giulio Formenti, Gage H Garcia, Luciana De Gennaro, David Gilbert, Richard E Green, Andrea Guarracino, Ishaan Gupta, Diana Haddad, Junmin Han, Robert S Harris, Gabrielle A Hartley, William T Harvey, Michael Hiller, Kendra Hoekzema, Marlys L Houck, Hyeonsoo Jeong, Kaivan Kamali, Manolis Kellis, Bryce Kille, Chul Lee, Youngho Lee, William Lees, Alexandra P Lewis, Qiuhui Li, Mark Loftus, Yong Hwee Eddie Loh, Hailey Loucks, Jian Ma, Yafei Mao, Juan F I Martinez, Patrick Masterson, Rajiv C Mccoy, Barbara Mcgrath, Sean Mckinney, Britta S Meyer, Karen H Miga, Saswat K Mohanty, Katherine M Munson, Karol Pal, Matt Pennell, Pavel A Pevzner, David Porubsky, Tamara Potapova, Francisca R Ringeling, Joana L Rocha, Oliver A Ryder, Samuel Sacco, Swati Saha, Takayo Sasaki, Michael C Schatz, Nicholas J Schork, Cole Shanks, Linnéa Smeds, Dongmin R Son, Cynthia Steiner, Alexander P Sweeten, Michael G Tassia, Françoise Thibaud-Nissen, Edmundo Torres-González, Mihir Trivedi, Wenjie Wei, Julie Wertz, Muyu Yang, Panpan Zhang, Shilong Zhang, Yang Zhang, Zhenmiao Zhang, Sarah A Zhao, Yixin Zhu, Erich D Jarvis, Jennifer L Gerton, Iker Rivas-González, Benedict Paten, Zachary A Szpiech, Christian D Huber, Tobias L Lenz, Miriam K Konkel, Soojin V Yi, Stefan Canzar, Corey T Watson, Peter H Sudmant, Erin Molloy, Erik Garrison, Craig B Lowe, Mario Ventura, Rachel J O'Neill, Sergey Koren, Kateryna D Makova, Adam M Phillippy, Evan E Eichler

Faculty Research 2025

The most dynamic and repetitive regions of great ape genomes have traditionally been excluded from comparative studies. Consequently, our understanding of the evolution of our species is incomplete. Here we present haplotype-resolved reference genomes and comparative analyses of six ape species: chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan and siamang. We achieve chromosome-level contiguity with substantial sequence accuracy (< 1 error in 2.7 megabases) and completely sequence 215 gapless chromosomes telomere-to-telomere. We resolve challenging regions, such as the major histocompatibility complex and immunoglobulin loci, to provide in-depth evolutionary insights. Comparative analyses enabled investigations of the evolution and diversity of regions previously uncharacterized or incompletely studied without bias from mapping to the human reference genome. Such regions include newly minted gene families in lineage-specific segmental duplications, centromeric DNA, acrocentric chromosomes and subterminal heterochromatin. This resource serves as a comprehensive baseline for future evolutionary studies of humans and our closest living ape relatives.

Clonal Dynamics And Somatic Evolution Of Haematopoiesis In Mouse., Chiraag D Kapadia, Nicholas Williams, Kevin J Dawson, Caroline Watson, Matthew J Yousefzadeh, Duy Le, Kudzai Nyamondo, Sreeya Kodavali, Alex Cagan, Sarah Waldvogel, Xiaoyan Zhang, Josephine De La Fuente, Daniel Leongamornlert, Emily Mitchell, Marcus A Florez, Krzysztof Sosnowski, Rogelio Aguilar, Alejandra Martell, Anna Guzman, David E Harrison, Laura J Niedernhofer, Katherine Y King, Peter J Campbell, Jamie Blundell, Margaret A Goodell, Jyoti Nangalia

Faculty Research 2025

Haematopoietic stem cells maintain blood production throughout life1 . Although extensively characterized using the laboratory mouse, little is known about clonal selection and population dynamics of the haematopoietic stem cell pool during murine ageing. We isolated stem cells and progenitors from young and old mice, identifying 221,890 somatic mutations genome-wide in 1,845 single-cell-derived colonies. Mouse stem cells and progenitors accrue approximately 45 somatic mutations per year, a rate only approximately threefold greater than human progenitors despite the vastly different organismal sizes and lifespans. Phylogenetic patterns show that stem and multipotent progenitor cell pools are established during embryogenesis, after which they …

Systematic Ocular Phenotyping Of Knockout Mouse Lines Identifies Genes Associated With Age-Related Corneal Dystrophies., Andrew Briere, Peter Vo, Benjamin Yang, David Adams, Takanori Amano, Oana Amarie, Zorana Berberovic, Lynette Bower, Steve D M Brown, Samantha Burrill, Soo Young Cho, Sharon Clementson-Mobbs, Abigail D'Souza, Mohammad Eskandarian, Ann M Flenniken, Helmut Fuchs, Valerie Gailus-Durner, Yann Hérault, Martin Hrabe De Angelis, Shundan Jin, Russell Joynson, Yeon Kyung Kang, Haerim Kim, Hiroshi Masuya, Hamid Meziane, Ki-Hoan Nam, Hyuna Noh, Lauryl M J Nutter, Marcela Palkova, Jan Prochazka, Miles Joseph Raishbrook, Fabrice Riet, Jason Salazar, Radislav Sedlacek, Mohammed Selloum, Kyoung Yul Seo, Je Kyung Seong, Hae-Sol Shin, Toshihiko Shiroishi, Michelle Stewart, Karen L. Svenson, Masaru Tamura, Heather Tolentino, Sara Wells, Wolfgang Wurst, Atsushi Yoshiki, Louise Lanoue, K C Kent Lloyd, Brian C Leonard, Michel J Roux, Colin Mckerlie, Ala Moshiri

Faculty Research 2025

PURPOSE: This study investigates genes contributing to late-adult corneal dystrophies (LACDs) in aged mice, with potential implications for late-onset corneal dystrophies (CDs) in humans.

METHODS: The International Mouse Phenotyping Consortium (IMPC) database, containing data from 8901 knockout mouse lines, was filtered to include late-adult mice (49+ weeks) with significant (P < 0.0001) CD phenotypes. Candidate genes were mapped to human orthologs using the Mouse Genome Informatics group, with expression analyzed via PLAE and a literature review for prior CD associations. Comparative analyses of LACD genes from IMPC and established human CD genes from IC3D included protein interactions (STRING), biological processes (PANTHER), and molecular pathways (KEGG).

RESULTS: Analysis identified 14 genes linked to late-adult abnormal corneal phenotypes. Of these, 2 genes were previously associated with CDs in humans, while 12 were novel. Seven of the 14 genes (50%) were expressed in the human cornea based on single-cell transcriptomics. Protein-protein interactions via STRING showed several significant interactions …

Challenges And Opportunities For Conceiving Genetically Diverse Sickle Cell Mice., Rafiou Agoro, Gary Churchill

Faculty Research 2025

A milestone in sickle cell disease (SCD) therapeutics was achieved in December 2023 with the FDA-approved gene therapy for patients aged 12 years and older. However, these therapies may only suit a fraction of patients because of cost or health risks. A better understanding of SCD outcome heterogeneity is needed to propose patient-specific pharmacological interventions. To achieve this, humanized and genetically diverse mouse models are essential for associating candidate genotypes with specific hematological traits, organ function, and disease resilience. Here, we discuss the challenges and opportunities in developing genetically diverse sickle cell mice (GDS mice). These models are expected to …

An Intranasal Subunit Vaccine Induces Protective Systemic And Mucosal Antibody Immunity Against Respiratory Viruses In Mouse Models., Aina Karen Anthi, Anette Kolderup, Eline Benno Vaage, Malin Bern, Sopisa Benjakul, Elias Tjärnhage, Fulgencio Ruso-Julve, Kjell-Rune Jensen, Heidrun Elisabeth Lode, Marina Vaysburd, Jeannette Nilsen, Marie Leangen Herigstad, Siri Aastedatter Sakya, Lisa Tietze, Diego Pilati, Mari Nyquist-Andersen, Mirjam Dürkoop, Torleif Tollefsrud Gjølberg, Linghang Peng, Stian Foss, Morten C Moe, Benjamin E. Low, Michael V. Wiles, David Nemazee, Frode L Jahnsen, John Torgils Vaage, Kenneth A Howard, Inger Sandlie, Leo C James, Gunnveig Grødeland, Fridtjof Lund-Johansen, Jan Terje Andersen

Faculty Research 2025

Although vaccines are usually given intramuscularly, the intranasal delivery route may lead to better mucosal protection and limit the spread of respiratory virus while easing administration and improving vaccine acceptance. The challenge, however, is to achieve delivery across the selective epithelial cell barrier. Here we report on a subunit vaccine platform, in which the antigen is genetically fused to albumin to facilitate FcRn-mediated transport across the mucosal barrier in the presence of adjuvant. Intranasal delivery in conventional and transgenic mouse models induces both systemic and mucosal antigen-specific antibody responses that protect against challenge with SARS-CoV-2 or influenza A. When benchmarked …

Evaluating The Feasibility Of Gene Replacement Strategies To Treat Mtrfr Deficiency., Samia L Pratt, Mariana Zarate-Mendez, Lidiia Koludarova, Sonja Jansson, Mikko Airavaara, Irena Hlushchuk, David Coleman, Caleb Heffner, Rita Horvath, Brendan J Battersby, Robert W. Burgess

Faculty Research 2025

Mitochondrial translation release factor in rescue (MTRFR) catalyzes a termination step in protein synthesis, facilitating release of the nascent chain from mitoribosomes. Pathogenic variants in MTRFR cause MTRFR deficiency and are loss-of-function variants. Here, we tested gene replacement as a possible therapeutic strategy. A truncating mutation (K155*) was generated in mice; however, homozygotes die embryonically whereas mice heterozygous for this K155* allele are normal. We also generated transgenic strains expressing either wild-type human MTRFR or a partially functional MTRFR. Despite dose-dependent phenotypes from overexpression in vitro, neither transgene caused adverse effects in vivo. In K155* homozygous mice, the wild-type MTRFR …

Who Gets To Have Fun? The Alternative Earmarking Of A Memecoin Marketplace, Mia Tanner

Sociology Honors Projects

Past research on cryptocurrency has highlighted its sociotechnical aspects, framing crypto projects as community-grounded movements disrupting traditional state and market structures through technological advancements. What happens when these disruptive promises are absent or only playfully invoked? Cryptocurrencies known as “memecoins” have grown their own followings without pledging future legitimacy that would seriously challenge existing institutions, instead linking their value to the meme they brand themselves with and vague democratic promises. That new scheme of valuation is especially evident in coins launched on the site pump.fun, which has lowered the barriers to crypto-coin creation. The platform's accessibility provides a new dimension …

Foreword: The ‘Why’ & How’ Of Artificial Intelligence In Legal Scholarship, Spencer Nayar, Michael I. Cooper

Texas A&M Journal of Property Law

In the course of publishing the 2024–25 Volume of the Texas A&M Journal of Property Law, we, the Editorial Board, were presented with the opportunity to publish a collection of articles drafted explicitly with the assistance of Artificial Intelligence (“AI”). After some consideration, we made the decision to do so. The following is our endeavor to share with our peers and colleagues—who may soon find themselves in similar situations—what we have learned in this process and, separately, contribute some forward-looking standards that can be implemented in the arena of legal scholarship for the transparent signaling and taxonomizing of AI-assisted works.

Assessing The Status And Distribution Of The Many-Lined Salamander (Stereochilus Marginatus) In Florida, Aubrey Heupel Greene, Kevin W. Christman, Jonathan D. Mays, Daniel U. Greene, David A. Steen

Florida Field Naturalist

To better understand the contemporary status and distribution of the many-lined salamander (Stereochilus marginatus) at the southern extent of the species’ range, we surveyed for the species within Florida between 2022 and early 2024, including both known historical locations and additional sites with apparently suitable habitat within occupied drainages. Prior to our study, many-lined salamanders had not been documented in the state since 1991 but we recorded 23 observations (eight adults and 15 juveniles) from two sites; the relatively few detections precluded analyses to better understand activity patterns or evaluate habitat quality. Many-lined salamanders remain extant in Florida but face …

Arthropods Collected From Common Yellowthroats (Geothlypis Trichas) On Vaca Key, Florida, Lawrence J. Hribar

Florida Field Naturalist

No abstract provided.

Front Matter Connecticut Law Review Volume 57 Issue 3

Connecticut Law Review

No abstract provided.

Investigation Into The Microbiome Of Blow Fly Eggs Using Microseqtm Id, Samantha S. Davis, Drusilla Sheridan, Jennifer Rosati

Undergraduate Research

There is little published research characterizing the microbiome associated with blow fly eggs and how they may affect the colonization behaviors of certain blow fly species. Once deposited, blow fly eggs are rapidly introduced to a diverse range of microorganisms, which can vary depending on the species of blow fly, the environment, and the decomposition stage of the substrate (Junqueira et al., 2017). Since blow flies are among the first insects to colonize decomposing remains, the microbial communities present on their eggs could serve as key indicators of the decomposition stage at the time of egg-laying, thus providing a potential …

Decoding Oncology-Focused Biotechnology Firms: Lifecycle Analysis And Predictive Insights For Valuation From A Junior Associate's Perspective, Kesav P. Chandrasekhar

Finance Undergraduate Honors Theses

Oncology-focused biotechnology firms present unique valuation challenges due to high R&D costs, long development timelines, and uncertain clinical outcomes. This thesis addresses such challenges by integrating the clinical development lifecycle with financial valuation models to provide predictive insights into company value. A structured framework is developed that primarily focuses on stage-specific probabilities of success (PoS) for drug candidates and their impact on firm valuation, embedded in techniques such sum-of-the-parts (SOTP) analysis. By quantitatively linking clinical trial phases and likelihoods of approval to cash flow projections, the model enables a more realistic, risk-adjusted estimation of a biotech firm's worth. Through lifecycle …

Commodification And Objectification Of The Black Male Athlete In The Nfl, Jalen A. Terrell

All Theses

The black male body has often been viewed as a commodity in Western culture since the commodification of the black male body in the historical slave auction. Albeit slave owning ended in 1863 with the Emancipation Proclamation, it was not until 1946 that the National Football League (NFL) became integrated, and the commodification of black bodies became prevalent once again. As such, this study looks to understand how the X population from the data set for this study demonstrates the commodification of the black male body, the general discourse around the black and white male athletes, and explores the language …

Living Heritage Along The Ganges: Building Resilient Communities In Varanasi And Kolkata, India, Ritu G. Deshmukh

Full-Text Theses & Dissertations

This doctoral research proposes an integrative theoretical framework for understanding and managing living heritage in riverine contexts, specifically focusing on the historic cities of Varanasi and Kolkata along the Ganges River in India. The study develops a new paradigm for living heritage conservation that embraces the fluid, dynamic nature of cultural landscapes through what the author terms the “Adaptive Fluid Living Heritage Continuum” (A.F.L.H.C).

Traditional approaches to heritage management often treat cultural landscapes and living heritage as static entities requiring preservation rather than living systems capable of adaptation. This research challenges this perspective by examining how communities along the Ganges …

Investigating Stress Hormone Variations In Green Frogs (Lithobates Clamitans) During The Mating Season, Abby Mciver

Electronic Theses and Dissertations

Monitoring stress hormones in wildlife populations is increasingly used to understand how human activities may impact the environment. The goal of this study was to quantify corticosterone in green frogs (Lithobates clamitans) at baseline levels and in response to an acute stressor throughout the mating season. The project was conducted from May to September of 2024 at Bays Mountain Park in Kingsport, Tennessee. Corticosterone levels were determined over six consecutive days each month from May to September using a non-invasive dermal swab technique. Additionally, body metrics, water chemistry, and weather and habitat conditions were evaluated on each sampling …

Tumor-Specific Surface Marker–Independent Targeting Of Tumors Through Nanotechnology And Bioorthogonal Glycochemistry, Hyesun Hyun, Bo Sun, Mostafa Yazdimamaghani, Albert Wielgus, Yue Wang, Stephanie Ann Montgomery, Tian Zhang, Jianjun Cheng, Jonathan S. Serody, Andrew Z. Wang

Chemical and Biochemical Engineering Faculty Research & Creative Works

Biological targeting is crucial for effective cancer treatment with reduced toxicity but is limited by the availability of tumor surface markers. To overcome this, we developed a nanoparticle-based (NP-based), tumor-specific surface marker–independent (TRACER) targeting approach. Utilizing the unique biodistribution properties of NPs, we encapsulated Ac4ManNAz (Maz) to selectively label tumors with azide-reactive groups. Surprisingly, while NP-delivered Maz was cleared by the liver, it did not label macrophages, potentially reducing off-target effects. To exploit this tumor-specific labeling, we functionalized anti–4-1BB Abs with dibenzo cyclooctyne to target azide-labeled tumor cells and activate the immune response. In syngeneic B16F10 melanoma and orthotopic 4T1 …

Virtually Unheard Of: Why U.S. Courts Needs Rules For Virtual Reality Evidence, Mahin Mughal

North Carolina Journal of Law & Technology

No abstract provided.

Path Tracing And Physically-Based Rendering With Directx Raytracing, Jiabin Wang

Programming Theses and Dissertations

This artifact is designed to simulate global illumination by using DirectX raytracing pipeline. Physically-based Rendering (PBR) and path tracing were integrated to achieve photo realistic rendering effect.

Collective Effervescence As Self-Organization And Enaction, Christian Kronsted

Philosophy Faculty Publications

No abstract provided.

The Scream Notation System: A Notational System For Screamed Vocals, Matthew Delcambre

Student Publications

In Western music notation, there is no specified system of notation for screamed vocals, a style of singing that has become increasingly popular since the late 1970s with the advent of metal music and seen increased interest in screams in other genres since. Screams are a unique and diverse vehicle of delivery that can be differentiated according to timbre, technique, pitch and physiology. This research aims to first identify the anatomical and timbral differences between named screams and create a database of screams to be studied. The next task is to design a notational system appropriate for screams and then …

Optimizing Growth Conditions Of Chlorella Algae For Enhanced Biomass And Oxygen Production, Supreme Ogheneovo Oghenerhoro

Master's Theses

Increasing Earth's carbon dioxide (CO₂) levels contribute immensely to global warming. At the same time, future Mars colonization requires innovative systems for oxygen production. This study explores how Chlorella algae can help control environmental challenges on Earth, support life on Mars, and produce biomass as an alternative to renewable energy. Chlorella is known for its high photosynthetic efficiency in capturing CO2 for growth, producing O2 and biomass used for biofuel production. It was studied under varying CO₂ concentrations and pressure conditions. Each experiment was performed using a photobioreactor setup and optimized algae growth conditions. These were assessed to understand its …

Impacts Of Temperature Acclimation On Swimming Performance And Metabolic Dynamics Of The Amargosa River Pupfish, Cyprinodon Nevadensis Amargosae, Teresa E. Guerre

Master's Theses

Climate change is leading to warmer atmospheric temperatures in many regions of the world, which in turn is raising the temperatures of aquatic habitats and simultaneously shifting the frequency and severity of extreme precipitation events. In fishes, metabolic demands are higher under warmer conditions, while dissolved oxygen levels typically decline in warmer water. This mismatch may limit the ability of fishes to cope with high water flow events like floods that can occur following extreme rainfall. A few species of pupfishes (genus Cyprinodon) in the Death Valley region of California and Nevada, USA, occupy stream or river habitats with …

Introducing Social Determinants Of Health To The Alzheimer's Disease Research Center Network, Megan Zuelsdorff, Erin L. Abner, Joyce E. Balls-Berry, Gregory A. Jicha, Serggio Lanata, Gladys E. Maestre, Monica Rosselli, Shana D. Stites, Rachel A. Whitmer, Consuelo H. Wilkins, Lisa L. Barnes

Epidemiology and Environmental Health Faculty Publications

The Alzheimer's Disease Research Centers (ADRCs) consortium represents a critical locus of research on Alzheimer's disease and related disorders (ADRD) prevention, diagnosis, and intervention. Through the National Alzheimer's Coordinating Center's (NACC) standardized protocol, the Uniform Data Set (UDS), ADRCs have collected rich, harmonizable clinical and cognitive data. However, the collection of social data has been sparse and Center specific, constraining ADRD science that addresses research priorities on social determinants of health (SDOH) and health equity. Capitalizing on the transition to a revised UDS version 4, an interdisciplinary committee representing 10 ADRCs reviewed the literature and instrumentation, ultimately creating a brief …

Investigating The Effect Of Fasting On Senescent Cells In Nothobranchius Furzeri Fish, Israel A. Akinola

Electronic Theses and Dissertations

Senescent cells (SCs) have been documented to accumulate with age in the organism. Recent studies have shown that reducing the number of SCs in an organism result in tissue rejuvenation and extension of life expectancy. Intermittent fasting is reported to have multiple health benefits and is speculated to reduce the burden of SCs. Nothobranchius furzeri are a new model organism for studying aging and for which there are short- and long-lived strains available. We hypothesize that long- and short-lived strains of N. furzeri will accumulate SCs at different rates; and that fasting will reduce the burden of SCs.

The results …