Digital Commons Network^™

Folk Art As A Catalyst: Unfolding Salvadoran Identity Through Design., Kevin E. Lopez

Bachelor of Architecture Theses - 5th Year

This research explores how folk art can act as a catalyst to revitalize spaces and deepen connections to Salvadoran culture. It examines works of folk art as cultural artifacts that embody Salvadoran identity, revealing their underlying structures, patterns, and meanings. This understanding of form and symbolism within these artistic expressions will serve as a foundation for translating cultural identity into architectural design.

Ideas and experiences can be ephemeral, but through design, these concepts can be translated into architectural forms. Knoespel argued in “Diagrammatic Transformation of Architectural Space” that diagrams conveys architectural information, suggesting that by analyzing an element, new information …

Understanding Loss Of Beta-Cell Identity And Progression Of Diabetes In Polygenic Mouse Models Of T2dm, Sumitkumar Patel

Arts & Sciences Graduate Student Theses and Dissertations

Type 2 diabetes (T2DM) is caused by the complex interaction of multiple genes and environmental factors. T2DM is characterized by hyperglycemia, insulin resistance in peripheral tissues and impaired insulin secretion by the pancreas. While the decline in insulin production and secretion was previously attributed to apoptosis of insulin-producing β-cells, recent studies indicate that β cell apoptosis rates are relatively low in diabetes. In this dissertation, I investigated β-cell failure in diabetes using KK and KKAy mouse models of polygenic T2DM, which spontaneously develop hyperglycemia, glucose intolerance, glucosuria, impaired insulin secretion and insulin resistance. I found that β-cell failure in KK …

Investigating The Roles Of Sox10 And Etv4 In Melanocyte And Melanoma Development, Catherine Marie Newsom-Stewart

Arts & Sciences Graduate Student Theses and Dissertations

The neural crest is a transient, multipotent cell population unique to vertebrates that gives rise to diverse lineages, including craniofacial cartilage, peripheral neurons, glia, and pigment-producing melanocytes. Proper specification and differentiation of neural crest derivatives are orchestrated by tightly regulated gene regulatory networks, and disruption of these developmental programs can lead to congenital disorders and malignancies. Melanocytes, derived from the neural crest, are best known for their role in skin pigmentation but also contribute to homeostasis and specialized functions in the eye, ear, and heart. These cells produce melanin to protect tissues from ultraviolet radiation and oxidative damage, and they …

On Appreciating Evidence, Auke Alesander Montesano Montessori

Arts & Sciences Graduate Student Theses and Dissertations

The topic of this dissertation is the kind of understanding or grasping necessary for successfully using something as evidence. I call this kind of grasp “appreciation”. Take the case of a fossil. Intuitively, you can only successfully use a fossil as evidence for the existence of dinosaurs if you appreciate the epistemic link between the fossil and dinosaurs. If you fail to grasp the relevance of the fossil and you think it is just a rock with a funny pattern, you would not be justified to form the belief that dinosaurs once existed based on that fossil. However, what it …

From Object To Architect: How Molly Bloom Designs Her Own Gaze In Joyce’S Ulysses, Mackenzie Hughes

The Criterion

No abstract provided.

Methods And Compositions Related To Modified Green Fluorescent Protein (Gfp) With An Embedded Foreign Peptide, Vladimir N. Uversky, Bogdan S. Melnik

USF Patents

Disclosed herein are methods and compositions comprising chimeric green fluorescent protein (GFP) molecules embedded with foreign molecules. Also disclosed are methods of treating a subject with chimeric GFP molecules embedded with foreign molecules. Further disclosed are methods of delivering a desired molecule to a cell, wherein said desired molecule is embedded within a chimeric GFP molecule.

Acetaminophen’S Contribution To Autism And Adhd From A Mitochondrial Perspective, Stephanie G. Chu

Senior Honors Theses

The CDC reported that one in 36 children were identified with autism in 2020, a 22% increase from 2018 and a 98% increase from 2010. Simultaneously, ADHD diagnoses increased 36% from 2003 to 2016-2019. Despite this surge, their etiologies remain largely unknown. However, numerous studies document higher incidences of mitochondrial abnormalities in affected individuals. Additionally, acetaminophen has been implicated in these disorders in longitudinal studies and murine models. This paper is a compilation of literature aiming to present a novel theoretical framework for acetaminophen-induced mitochondrial damage in utero. It focuses on a toxic metabolite of acetaminophen, N-acetyl-p-benzoquinone imine, and its …

Rose Craig Art399 Portfolio, Rose M. Craig

Professional Practices (ART 399)

My work often explores personal narratives related to family and childhood, using line, shape, form, and value in a representational style. Heirloom, a cylindrical nickel box with a symmetrical design of organic and geometric shapes, reminiscent of 1930s pill boxes, featuring a mother-of-pearl. Inside the box is a small brass pillbox hat. I chose to create a design and a hat that calls back to the word pill to not only symbolize heirlooms but also how mental illness can be passed down generationally. The mother of pearl symbolizes my family’s traditions of passing down heirlooms from mother to daughter.

While …

How Extreme Rainfall And Failing Dams Unleashed The Derna Flood Disaster, Ayman Mokhtar Nemnem, Ahad Hasan Tanim, Audrika Nahian, Sadik Khan, Erfan Goharian, Jasim Imran

Faculty Publications

On September 11, 2023, Storm Daniel unleashed unprecedented rainfall over the Wadi Derna watershed, triggering one of the most devastating floods in modern history, striking Derna, a coastal city in Libya. This study reconstructs the disaster using an integrated modeling approach that combines satellite imagery, hydrologic, hydraulic, and geotechnical simulations, machine learning, eyewitness accounts, and digital elevation data to assess the impact of cascading dam failures. Our findings reveal that the region’s dams, even if structurally sound, would have provided minimal protection against the extreme runoff. However, their failure unleashed a destructive surge wave, amplifying the disaster’s magnitude and devastation. …

Sustainable Solutions: Innovating Vernacular Architecture In Togo's Communities, Kevin Toudeka

Bachelor of Architecture Theses - 5th Year

Togo, like many other countries, faces significant challenges in the housing sector, particularly for low-income communities. Traditional or vernacular architecture offers a rich repository of knowledge and practices that can be harnessed to address these challenges in a sustainable and culturally appropriate manner. Exploring innovative approaches to vernacular architecture will improve affordability, comfort, and resilience while preserving cultural heritage. Innovating vernacular architecture presents an opportunity to address housing challenges in Togo in a culturally sensitive, environmentally sustainable, and socially inclusive manner. Traditional knowledge and practices, combined with modern technologies and collaborative approaches, can create housing solutions that are both rooted …

Plastic Repurposed: Explorations For The Use Of Plastic Waste As An Architectural Element, Caleb Tinajero

Bachelor of Architecture Theses - 5th Year

The business model for plastic has become accustomed to a system of consumption and disposal that has failed to develop a way that benefits the environment. Unless the production of plastic ceases to persist, the number of plastic waste will continue to grow and even though it is not fully visible, the effects of this pollution will eventually contaminate the aspects of our lives. Although stopping the production of such a vital factor to the prosperity of the economy is unrealistic, it could also be detrimental to the machinations of society. It is after all a very useful resource. The …

Nature's Nexus; Revival Of The Mall Typology Through Nature, Bailey Wilson

Bachelor of Architecture Theses - 5th Year

Many suburban shopping malls are struggling today due to online shopping, questions of access, and monolithic experience among other things. The Savannah mall, abandoned in 2023, provides an opportunity for exploration in the revival of the mall typology through biophilic design. This project explores the nexus between Savannah’s landscape and the abandoned mall. Therefore, envisioning a future where malls evolve from heat island hardscapes into environments that create a nexus between nature and community.

Urban Eden, Establishing The Groundwork For A More Resilient City, Max R. Oliva

Bachelor of Architecture Theses - 5th Year

Cities account for over 70% of Global C02 emissions and as these areas grow over time their Carbon Footprint will grow in turn. In order to offset this imbalance I propose to design Performative Skins & Building Modules to not only reduce the carbon footprint in these cities, but also recover their connection to Nature contributing not only to energy efficiency and air quality, but also to urban aesthetics, the inclusion of these systems could go so far as to help mitigate the heat island effect and in the long term help establish a more resilient and sustainable city

Defining Space With Bamboo, Nicholas A. Stile Jr.

Bachelor of Architecture Theses - 5th Year

Defining Space with Bamboo explores the architectural potential of bamboo in the subtropical climate of the United States—specifically challenging the preconception of bamboo as merely an invasive species. While it’s true that bamboo is non-native and fast-spreading, its presence is already well-established across the region. This project asks: rather than resisting it, what if we embraced bamboo as a rapidly renewable, structurally versatile construction material?

Set along the Atlanta BeltLine, the project comprises three spatial installations—small, medium, and large—each designed to examine how bamboo can actively define space through qualities of leisure, activity, and discovery. The small pavilion employs a …

The Diamond, May 6, 2025, Dordt University

Dordt Diamond

• Front Page: Dordt Buys Northwest Iowa Symphony Orchestra; Cheer Team Cinches Championship Title at Nationals; Deportation Initiatives Challenge Defenders
• News: The Question of Capping Enrollment; Tariff War Pivots to China
• Feature: Senior Farewells; Letter to the Editor; Letter from the Editor; Hands-On at Ag Day; Prayer for the Nations Introduced to Dordt; Bringing Beauty and Biblical Truth From Art Into Ministry - A Farewell to Professor Ryan Eckert; Senior Spotlight; Social Work Class Hosts "Colors of Courage" Color Run
• Arts & Entertainment: A Campus Tour of Senior Art Exhibits; Raising Awareness: The Ice Bucket Challenge
• Opinion …

Development Of A Miniaturized Extracorporeal Membrane Oxygenation (Ecmo) Device On A Microfluidic Platform, Nayeem Imtiaz

Theses

This research investigates the design, performance, and optimization of blood-contacting microfluidic medical devices, with each aim contributing to a broader understanding of how engineering choices influence hemocompatibility and oxygen transfer. Collectively, the findings from Aims 1A–2B offer integrated strategies to develop safer, more effective microfluidic systems for ECMO and dialysis. Aim 1A assessed hemolysis across device geometries using computational and experimental methods. All designs showed low device-induced hemolysis (< 2 ppm), validating their hemocompatibility. However, Power-Law models frequently overpredicted hemolysis, indicating a need for refined parameters tailored to microfluidic flow conditions. Aim 1B demonstrated the effectiveness of thrombosis assay techniques in evaluating clot formation in microfluidic device geometries. Results showed that geometry and local shear patterns strongly influence thrombogenesis. While hemolysis remained minimal even in high-shear devices, thrombus formation was more geometry-sensitive—underscoring the need to account for both factors in design. Modifying surface properties and accounting for blood composition could further reduce thrombotic risk. In Aim 2A, we compared PDMS, polypropylene (PP), and nanoporous silicon nitride (NPSiN) membranes for oxygen transport. Findings showed that in ECMO devices, blood-side resistance, not membrane permeability, often dominates oxygen transfer. Thus, membrane choice must be paired with optimized blood-side flow for full performance gains. Aim 2B directly addressed these limitations by integrating staggered herringbone mixers (SHBs), which introduced secondary flows and enhanced mixing. The Single Channel Herringbone design yielded the highest oxygen transfer, confirming the synergy between flow geometry and oxygen transport performance. Altogether, Aims 1A and 1B establish a strong framework for hemocompatibility evaluation, while Aims 2A and 2B provide complementary insights into optimizing oxygen transfer. Their interconnections highlight the value of a systems-level approach to designing microfluidic blood-contacting devices.

Soft Modular Robots: From Modular Tensegrity Structures To Bioinspired Sea Robots, Luyang Zhao

Dartmouth College Ph.D Dissertations

The rapid advancement of robotics necessitates systems capable of adapting to complex, unstructured environments. Soft robots, with their flexibility and compliance, excel in delicate interactions, making them ideal for medical applications and search-and-rescue missions. Modular robots, on the other hand, offer reconfigurability, enabling diverse task-specific adaptations in dynamic settings. Despite their individual advantages, the integration of soft and modular robotics remains underexplored. This proposal aims to develop soft modular robots that combine the adaptability of soft robotics with the versatility of modularity. These systems will be capable of autonomously transitioning between locomotion, manipulation, and infrastructure assembly across land, water, and …

The Critical Balance Between Quiescence And Reactivation Of Neural Stem Cells, Adam Elkin, Sarah Robbins, Claudia Barros, Torsten Bossing

Peninsula Medical School

Neural stem cells (NSC) are multipotent, self-renewing cells that give rise to all neural cell types within the central nervous system. During adulthood, most NSCs exist in a quiescent state which can be reactivated in response to metabolic and signalling changes, allowing for long-term continuous neurogenesis and response to injury. Ensuring a critical balance between quiescence and reactivation is required to maintain the limited NSC reservoir and neural replenishment throughout lifetime. The precise mechanisms and signalling pathways behind this balance are at the focus of current research. In this review, we highlight and discuss recent studies using Drosophila, mammalian and …

Emotional Labour In The Boundary Work Of Filipino Transnational Workers In Indian Cities, Jozon A. Lorenzana

Department of Communication Faculty Publications

This article examines the boundary work undertaken by Filipino transnational workers in globalizing Indian cities. While the ‘practice turn’ in boundary studies has shed light on boundary work's mundane and performative dimensions, the role of emotions in performing such work needs to be ascertained. To account for both the performative and emotional dimensions of boundary work, I present an ethnographic study on Filipino professionals in India that engages Hochschild's concept of emotional labour. Since the mid-2000s, local and multinational companies have hired Filipino professionals to set up businesses and manage operations. I examined their practices of boundary work through in-depth …

Simplified Control Of Neuromuscular Stimulation Systems For Restoration Of Reach With Limb Stiffness As A Modifiable Degree Of Freedom, Tyler R Johnson, Chase A Haddix, A Bolu Ajiboye, Dawn M Taylor

Faculty, Staff and Student Publications

Objective. Brain-controlled functional electrical stimulation (FES) of the upper limb has been used to restore arm function to paralyzed individuals in the lab. Able-bodied individuals naturally modulate limb stiffness throughout movements and in anticipation of perturbations. Our goal is to develop, via simulation, a framework for incorporating stiffness modulation into the currently-used ‘lookup-table-based’ FES control systems while addressing several practical issues: (1) optimizing stimulation across muscles with overlap in function, (2) coordinating stimulation across joints, and (3) minimizing errors due to fatigue. Our calibration process also needs to account for when current spread causes additional muscles to become activated. Approach. …

Axl Promotes Inflammatory Breast Cancer Progression By Regulating Immunosuppressive Macrophage Polarization, Lan T H Phi, Yating Cheng, Yohei Funakoshi, Francois Bertucci, Pascal Finetti, Steven J Van Laere, Fang Zou, James P Long, Suguru Ogata, Savitri Krishnamurthy, James M Reuben, Jason M Foulks, Steven L Warner, Jennifer M Rosenbluth, Anil K Sood, Debu Tripathy, Naoto T Ueno, Xiaoping Wang

Faculty, Staff and Student Publications

Background: Tumor-associated macrophages (TAMs) are key promoters of inflammatory breast cancer (IBC), the most aggressive form of breast cancer. The receptor tyrosine kinase AXL is highly expressed in various cancer types, including IBC, but its role in TAMs remains unexplored.

Methods: We examined the effects of AXL inhibitor TP-0903 on tumor growth and tumor microenvironment (TME) component M2 macrophages (CD206+) in IBC and triple-negative breast cancer mouse models using flow cytometry and immunohistochemical staining. Additionally, we knocked out AXL expression in human THP-1 monocytes and evaluated the effect of AXL signaling on immunosuppressive M2 macrophage polarization and IBC cell growth …

Improving The Reproducibility Of Deep Learning Software: An Initial Investigation Through A Case Study Analysis, Nikita Ravi, Abhinav Goel, James C. Davis, George K. Thiruvathukal

Computer Science: Faculty Publications and Other Works

The field of deep learning has witnessed significant breakthroughs, spanning various applications, and fundamentally transforming current software capabilities. However, alongside these advancements, there have been increasing concerns about reproducing the results of these deep learning methods. This is significant because reproducibility is the foundation of reliability and validity in software development, particularly in the rapidly evolving domain of deep learning. The difficulty of reproducibility may arise due to several reasons, including having differences from the original execution environment, incompatible software libraries, proprietary data and source code, lack of transparency, and the stochastic nature in some software. A study conducted by …

Origami Lunar Habitation Unfolding A Future Colony In Space, Andrew Fields

Bachelor of Architecture Theses - 5th Year

What is origami? Origami is the ancient Japanese art of folding paper into decorative pieces. Today we use origami as a way to compact things for better storage or transportation and still to create decorative pieces of art. Origami is a must in space travel as it allows for large satellites to be folded and compacted down into a rocket and then unfolded in space to allow for the most surface area for solar absorption.

How can origami help? By making it possible to create lightweight, expandable structures that can be used in alien environments and by enabling the repair …

Progressive Multifocal Leukoencephalopathy In Chimeric Antigen Receptor T-Cell Therapy Recipients: A Case Study, Michelly Abreu, Chirag B Patel, Krina Patel, Fareed Khawaja, Sudhakar Tummala

Faculty, Staff and Student Publications

Chimeric antigen receptor (CAR) T-cell therapy is a novel immunotherapy modality that has shown remarkable response rates in refractory hematologic malignancies, including multiple myeloma (MM). Cytokine release syndrome (CRS) and neurotoxicity are well-described side effects of this therapy. CAR T-cell therapy recipients are also at increased risk for infections due to immune dysfunction, history of multiple lines of therapy, history of lymphodepleting chemotherapy prior to cell infusion, and prolonged B-cell aplasia. Progressive multifocal leukoencephalopathy (PML) is an opportunistic disease of the central nervous system caused by the reactivation of JC virus (JCV) in the setting of immunosuppression, which leads to …

Perspectives On Using Multimedia In Social Studies For Student Engagement In Marginalized Youth: A Case Study, Dorrian Swinger

Dissertations

Abstract

Marginalized youth are currently facing an academic crisis in schools. Research has shown that marginalized youth are statistically more likely to drop out of school and not graduate from high school (defined as the academic crisis in this study). One reason for these high drop-out rates is disengagement in what is taught and how content is delivered in school. When students cannot relate or connect to their studies, it causes disengagement and uninterest in school. The disengagement can lead to a lack of academic success, which creates negative motivation to drop out of school. The more marginalized youth are …

Afflicted Epistemology: Knowledge, Illness, And New Media After “Truth”, Annika Nilsson

Arts & Sciences Graduate Student Theses and Dissertations

This study examines how people living with complex, medically underdetermined chronic illnesses make sense of their experiences through self-experimentation mediated by online forums and self-help groups in a cultural context characterized by significant controversy surrounding the status of science, expertise, and conventionally authoritative knowledge-producing institutions. Using virtual and conventional ethnography and critical media studies methods, it finds that the fragmentary and decentralized nature of the U.S. healthcare system intensified the interpretive challenges associated with complex chronic illnesses: information was extremely abundant, but deciphering its accuracy, reliability, and relevance proved difficult. In this context, participants relied on experiential knowledge to filter, …

Effects Of Angptl3 Deficiency On The Regulation Of Hepatic Lipoprotein Production And Lipid Metabolism, Kendall Helene Burks

Arts & Sciences Graduate Student Theses and Dissertations

Cardiovascular disease is the leading cause of death worldwide. A major treatment goal is to lower plasma lipids, especially low-density lipoprotein cholesterol (LDL), the cardinal risk factor for coronary artery disease (CAD). Patients with familial hypercholesterolemia (FH) experience early-onset CAD due to extremely high LDL. Underdiagnosis and undertreatment of FH are exacerbated by limited therapeutic options. However, one strategy has successfully lowered LDL in FH patients: Inhibition of the hepatically secreted protein Angiopoietin-like protein 3 (ANGPTL3). Despite promising clinical data, the mechanism by which ANGPTL3 inhibition lowers LDL has not been fully described. Although ANGPTL3 has been shown to modulate …

Jarid2-Mediated Reprogramming Of Human Hematopoietic Progenitors For Stem Cell Transplantation, Wentao Han

Arts & Sciences Graduate Student Theses and Dissertations

Hematopoietic stem cell transplantation (HSCT) is a well-established treatment for various hematological disorders. Umbilical cord blood (UCB) has emerged as an alternative source of hematopoietic stem and progenitor cells (HSPCs). However, the limited number of functional repopulating cells in UCB units has encouraged researchers to develop methods to expand them ex vivo. Hematopoiesis is strictly regulated by epigenetic modifiers. JARID2 is a co-factor of the Polycomb Repressive Complex 2 (PRC2), which recruits the complex to specific genomic loci and promotes the deposition of Histone 3 lysine 27 trimethylation (H3K27me3), a repressive epigenetic mark that mediates condensed chromatin packing to silence …

The Role Of Il-33 In Itch, Anna M. Trier

Arts & Sciences Graduate Student Theses and Dissertations

Chronic itch is associated with a broad range of medical conditions, from inflammatory skin diseases to cancer and organ dysfunction, and has a lifetime prevalence of up to 20%. Despite being common and debilitating, the cellular and molecular mechanisms that drive chronic itch are just beginning to be elucidated. Thus, therapeutic options are limited. Recent studies have identified that various pro-inflammatory cytokines can directly activate sensory neurons. This has resulted in mounting interest in the therapeutic potential of inhibiting these neuro-immune interactions. IL-33 is constitutively expressed by epithelial cells, which allows for its rapid release upon tissue damage or stress. …

Evaluating A Proprietary Tannin-Blend Product As An Alternative To Monensin And Tylosin Phosphate In Feedlot Cattle Diets, Luana D. Felizari, Luke K. Fuerniss, Jonathon L. Beckett, David S. Secrist, Guy D. Hufstedler, Bradley J. Johnson

Animal, Dairy, and Veterinary Science Faculty Publications

This study evaluates the effects of a proprietary tannin blend (BX), supplemented with or without sodium monensin (MON), on beef cattle performance, carcass traits, and health. Steers (n = 2986; initial shrunk body weight (SBW) 254 ± 9.2 kg) were allocated into 48 pens (61–62 steers/pen; 12 pens/treatment) fed for 230 d. Treatments included (1) no feed additives (CTL); (2) BX (7.95 g/animal daily); (3) MON + Tylosin phosphate (TYL; 437.52 mg MON/animal daily + 80 mg TYL/animal daily); or (4) MON+BX (437.52 mg MON/animal daily + 7.95 g BX/animal daily). Data were analyzed in R 4.2.1 using a …