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Articles 24571 - 24600 of 732791

Full-Text Articles in Entire DC Network

Taxonomic Revision Of Korean Salix Section Subviminales Based On Comparative Morphology And Complete Plastome Analysis, Young Moon Kim, Shukherdorj Baasanmunkh, Nudkhuu Nyamgerel, Won Seok Lee, Dong Chan Son, In Kyu Park, Bom Bi Jin, Hyo Sig Won, Hyeok Jae Choi May 2025

Taxonomic Revision Of Korean Salix Section Subviminales Based On Comparative Morphology And Complete Plastome Analysis, Young Moon Kim, Shukherdorj Baasanmunkh, Nudkhuu Nyamgerel, Won Seok Lee, Dong Chan Son, In Kyu Park, Bom Bi Jin, Hyo Sig Won, Hyeok Jae Choi

Turkish Journal of Botany

Salix section Subviminales, including only three species, is endemic to East Asia. In this study, we revised three species, S. gracilistyla, S. graciliglans, and S. blinii in Korea based on their plastomes and extensive morphological analyses to provide a comprehensive understanding of their taxonomic relationships. Based on our findings, we identified the morphological characteristics of S. blinii endemic to Korea, including its small size and distinct leaf shapes, which are well distinguished from both S. gracilistyla and S. graciliglans. Most of the morphological characteristics of S. gracilistyla and S. graciliglans overlapped, particularly leaf shape, floral structure, and growth habits. Next, …

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Rhetoric Of Soft Power And Public Diplomacy A Case Study Of Saudi Arabia, Sihmy Algamedi May 2025

Rhetoric Of Soft Power And Public Diplomacy A Case Study Of Saudi Arabia, Sihmy Algamedi

Electronic Theses and Dissertations

Soft power is the capacity to exert influence over the actions of others in order to accomplish one's goals. It refers to the ability to influence others without seeking any tangible benefits. Soft power emanates from a country's cultural, political beliefs, and foreign policies. Soft power refers to the capacity to achieve desired outcomes using methods that involve shaping the agenda, employing persuasion, and generating positive appeal (Alkatheeri, and Khan 26). In order for this endeavor to achieve success, the concept of legitimacy plays a pivotal role in the effectiveness of soft power. Public diplomacy is a component of foreign …

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St6galnac-I Regulates Tumor Cell Sialylation Via Nectin2/Muc5ac-Mediated Immunosuppression And Angiogenesis In Non-Small Cell Lung Cancer, Muthamil Iniyan Appadurai, Sanjib Chaudhary, Ashu Shah, Gopalakrishnan Natarajan, Zahraa W. Alsafwani, Parvez Khan, Dhananjay D. Shinde, Subodh M. Lele, Lynette M. Smith, Mohd W. Nasser, Surinder K. Batra, Apar Kishor Ganti, Imayavaramban Lakshmanan May 2025

St6galnac-I Regulates Tumor Cell Sialylation Via Nectin2/Muc5ac-Mediated Immunosuppression And Angiogenesis In Non-Small Cell Lung Cancer, Muthamil Iniyan Appadurai, Sanjib Chaudhary, Ashu Shah, Gopalakrishnan Natarajan, Zahraa W. Alsafwani, Parvez Khan, Dhananjay D. Shinde, Subodh M. Lele, Lynette M. Smith, Mohd W. Nasser, Surinder K. Batra, Apar Kishor Ganti, Imayavaramban Lakshmanan

Journal Articles: Biochemistry & Molecular Biology

Glycosylation controls immune evasion, tumor progression, and metastasis. However, how tumor cell sialylation regulates immune evasion remains poorly characterized. ST6GalNAc-I, a sialyltransferase that conjugates sialic acid to the glycans in glycoproteins, was overexpressed in an aggressive-type KPA (KrasG12D/+ Trp53R172H/+ Ad-Cre) lung adenocarcinoma (LUAD) model and patient samples. Proteomic and biochemical analysis indicated that ST6GalNAc-I mediated NECTIN2 sialylation in LUAD cells. ST6GalNAc-I-deficient tumor cells cocultured with T cells were more susceptible to T cell-mediated tumor cell killing, indicating a key role for NECTIN2 in T cell dysfunction. Mice injected with St6galnac-I-knockdown syngeneic cells showed reduced lung tumor incidence and Nectin2/Tigit-associated immunosuppression. …

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Finite Element Analysis Of Stress Distribution In Unilateral Distal Extension Partial Dentures: A Comparison Of Four Attachment Designs, Maha Nagy Kamal, Haitham Amr, Abdallah Shokry May 2025

Finite Element Analysis Of Stress Distribution In Unilateral Distal Extension Partial Dentures: A Comparison Of Four Attachment Designs, Maha Nagy Kamal, Haitham Amr, Abdallah Shokry

Dentistry

No abstract provided.

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The Role-Space Of Italian Sign Language Educational Interpreters: An Ethnographic Case Study Of Interpreters At The Istituto Comprensivo Di Cossato, Martin A. Crudo May 2025

The Role-Space Of Italian Sign Language Educational Interpreters: An Ethnographic Case Study Of Interpreters At The Istituto Comprensivo Di Cossato, Martin A. Crudo

Language, Literacy, and Sociocultural Studies ETDs

This dissertation explores the role-space of educational interpreters at IC Cossato, an Italian public school known for its Bilingualism Project promoting LIS-Italian bilingualism and biliteracy (Rivisto, 2016; Teruggi, 2003). Role-space theory (Lee, 2023; Llewellyn-Jones & Lee, 2013, 2014) conceptualizes interpreters’ roles as dynamic and co-constructed with interlocutors along three axes: Presentation of Self, Interaction Management, and Participant Alignment. Through ethnographic interviews (Spradley, 2016), observations and field notes (Emerson et al. 2011; Glesne, 2016), and policy artifacts (Hornberger & Johnson, 2011), I investigate how three interpreters in IC Cossato’s elementary school perceive and enact their roles, often diverging from their …

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Ecological Assessment Of Lentic Ecosystems In Ceyhan River Basin Using Phytoplankton Indices, Abuzer Çelekli̇, Emi̇ne Yonca Gümüş, Tolga Çeti̇n May 2025

Ecological Assessment Of Lentic Ecosystems In Ceyhan River Basin Using Phytoplankton Indices, Abuzer Çelekli̇, Emi̇ne Yonca Gümüş, Tolga Çeti̇n

Turkish Journal of Botany

Increasing exploitation of water resources has led to declining water quality in aquatic environments. Freshwater ecosystems face various environmental pressures, such as the impacts of climate change and intensifying land-use practices. This study aimed to assess the ecological preferences of phytoplankton communities and determine the ecological status (ES) of several reservoirs and lakes in Ceyhan River Basin across different seasons. A canonical correspondence analysis was conducted to understand the associations between phytoplankton assemblages and stressors in freshwater ecosystems, revealing a strong correlation of 97%. The factors that most influenced the distribution of phytoplankton species were electrical conductivity (EC), temperature, total …

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Sickle Cell Mice Exhibit Elevated Plasma Bilirubin And Altered Intracranial Cerebral Blood Velocities That Are Exacerbated By Hypoxia-Reoxygenation, Francisco J. Nunez, Ashraf M. Mohieldin, Amy Y. Pan, Sean P. Palecek, Rahima Zennadi, Ramani Ramchandran, Kevin R. Rarick, Surya M. Nauli May 2025

Sickle Cell Mice Exhibit Elevated Plasma Bilirubin And Altered Intracranial Cerebral Blood Velocities That Are Exacerbated By Hypoxia-Reoxygenation, Francisco J. Nunez, Ashraf M. Mohieldin, Amy Y. Pan, Sean P. Palecek, Rahima Zennadi, Ramani Ramchandran, Kevin R. Rarick, Surya M. Nauli

Pharmacy Faculty Articles and Research

Sickle cell disease (SCD) is a genetic disorder characterized by sickle red blood cells (RBCs). Sickle RBCs cause cerebral vasculopathies including vaso-occlusive events, leading to ischemia-reperfusion injury and hypoxic tissue environment. To date, the physiological blood flow velocities in cerebral vessels of preclinical SCD models has not been evaluated under hypoxic-reoxygenation. In our study, we used transcranial ultrasound techniques to measure abnormal blood flow velocities in the internal carotid (ICA) and middle cerebral arteries (MCA) of transgenic sickle cell mice (SS) challenged with hypoxia-reoxygenation. Our study showed that SS mice that underwent hypoxic stress exhibited lower relative mean velocities in …

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Creating A Shade Tree Commission For Shamokin, Skye Sunderhauf, Beth Williams, Marques Owens, Olivia Follansbee May 2025

Creating A Shade Tree Commission For Shamokin, Skye Sunderhauf, Beth Williams, Marques Owens, Olivia Follansbee

Final Reports in ENST 411: Environmental Community Projects

Final Project for ENST411 Environmental Community Projects

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Turtle Creek Tree Restoration Project, Rebecca Beneroff, Risa Kanefsky, Max Dicerbo, Pj Newhart, Amanda Mitchell May 2025

Turtle Creek Tree Restoration Project, Rebecca Beneroff, Risa Kanefsky, Max Dicerbo, Pj Newhart, Amanda Mitchell

Final Reports in ENST 411: Environmental Community Projects

Over the course of this project our group members Rebecca, Max, PJ, Amanda, and Risa worked closely with Jim Knight and Brian Auman from Turtle Creek Park to help research, plan, and execute a tree transplanting event that would be efficiently implemented and environmentally sound. This work involved extensive preparatory work in the park including soil testing, bare leaf tree identification, tree and shrub species characterization, and recommendation. The entire process was rooted in the most up to date literature and scientific practices surrounding bare root tree nurseries, existing land management plans, invasive species and public park management, ecological succession, …

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Mechanisms That Contribute To Age-Dependent Segregation Errors In Drosophila Oocytes, Zihan Meng May 2025

Mechanisms That Contribute To Age-Dependent Segregation Errors In Drosophila Oocytes, Zihan Meng

Dartmouth College Ph.D Dissertations

Meiotic chromosome segregation errors in human oocytes are the leading cause of miscarriages and aneuploid pregnancies, and these errors increase dramatically as women age. Using Drosophila oocytes as a model system, this dissertation identifies the NAD⁺-dependent deacetylase Sirt1 as a key regulator of chromosome segregation and meiotic arm cohesion. Loss of Sirt1 activity during meiotic prophase leads to premature loss of arm cohesion and increased segregation errors in Drosophila oocytes. In addition, elevated acetylation of its substrate, histone H4K16, indicates that Sirt1 activity declines in oocytes during aging. Strikingly, dietary administration of the Sirt1 activator SRT1720 preserves Sirt1 deacetylase activity …

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The Science Behind Free Rebound, Ryan Nash Bond May 2025

The Science Behind Free Rebound, Ryan Nash Bond

UNLV Theses, Dissertations, Professional Papers, and Capstones

This document examines a history of the the percussion stroke used throughout history leading to Free Rebound. It focuses on how grip, technique, and pedagogy have evolved over time through various pedagogues. The concept and stroke motion in Free Rebound was first advocated by George Lawrence Stone, Billy Gladstone, Fred Hinger, Buster Bailey, Ed Soph, and Joe Morello, it was implemented in playing and teaching by Gary Cook, and furthered by Dean Gronemeier. This discussion aims to support professionals', students', and teachers' interests by discussing the pedagogies of different approaches over time. The health and wellness section helps to discuss …

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A Comparative Study Of Music Between Mongolia And The Mongolian Ethnic Minority In China: Cultural Backgrounds, Musical Styles, And Modern Developments, Yile Huang May 2025

A Comparative Study Of Music Between Mongolia And The Mongolian Ethnic Minority In China: Cultural Backgrounds, Musical Styles, And Modern Developments, Yile Huang

UNLV Theses, Dissertations, Professional Papers, and Capstones

This thesis conducts a comparative study of Mongolian music traditions as they have developed both within Mongolia and among the Mongolian ethnic minority in China, exploring their cultural backgrounds, musical styles, and contemporary developments. By investigating the historical, geographical, and socio-cultural influences that shape the music in these regions, this study highlights the unique musical identities of each group while uncovering their commonalities and cultural exchanges. Drawing from a wide range of sources—including ethnographic studies and analysis of specific musical pieces—this research examines foundational elements such as the Mongolian long song, throat singing, and horsehead fiddle music. These traditional forms …

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Planting Seeds, Changing Minds: A Narrative Analysis Of Environmental Children’S Books, Julianna Jovillar May 2025

Planting Seeds, Changing Minds: A Narrative Analysis Of Environmental Children’S Books, Julianna Jovillar

UNLV Theses, Dissertations, Professional Papers, and Capstones

Children’s books are some of the earliest forms of entertainment and education a person will interact with in their lifetime. Simultaneously weaving a tale and teaching a lesson, children’s books, therefore, have the great potential to communicate important lessons and mindsets at young ages. Utilizing narrative theory (Fisher, 1984) and ecocriticism (Glotfelty, 1996), while also considering environmental ideologies and narrative components (Bloomfield, 2024), this study explores the functions of environmental children’s books and how they might communicate environmental messaging and encourage ecological thinking. Following a narrative analysis of 46 environmental children’s books, the results of this study indicate that there …

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Assessing The Effects Of Streptozotocin-Induced Hyperglycemia On Amyloid Beta Accumulation And Cognitive Behavior In A Mouse Model Of Alzheimer’S Disease-Related Pathology, Andrew Adonay Ortiz May 2025

Assessing The Effects Of Streptozotocin-Induced Hyperglycemia On Amyloid Beta Accumulation And Cognitive Behavior In A Mouse Model Of Alzheimer’S Disease-Related Pathology, Andrew Adonay Ortiz

UNLV Theses, Dissertations, Professional Papers, and Capstones

Alzheimer’s disease (AD) is an irreversible and devastating neurodegenerative disease characterized by progressive synaptic, dendritic, glial, and neuronal loss, collectively leading to impairments in learning, memory, and deterioration of cognitive and behavioral functions. AD is the most common form of dementia accounting for 60-80% of all cases. AD affects approximately 7 million Americans and is the 6th leading cause of death in the US. Furthermore, by 2050, the US is projected to spend over $1.1 trillion on AD-related treatments. Pathological hallmarks of AD include beta-amyloid (Aβ) plaques, intracellular neurofibrillary tangles (NFTs), and chronic neuroinflammation, which can promote and exacerbate both …

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Detection And Quantification Of Total Airborne Fungi And Coccidioides Species In Environmental Samples, Theresa T. Roehr May 2025

Detection And Quantification Of Total Airborne Fungi And Coccidioides Species In Environmental Samples, Theresa T. Roehr

UNLV Theses, Dissertations, Professional Papers, and Capstones

Fungal exposure can cause acute and chronic illnesses or exacerbate existing illnesses. Some fungi are opportunistic pathogens and can lead to serious systemic fungal infections. In 2020, more than 150 million cases of severe fungal infections were reported globally resulting in an estimated 1.7 million deaths. Coccidioidomycosis, or Valley fever, is classified as a serious fungal infection caused by the fungi Coccidioides immitis and C. posadasii. These particular fungi are prevalent in the soil of the Southwestern United States, including Las Vegas, Nevada. In 2024, there were a total of 269 cases of Valley fever reported in Nevada, and …

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Genome-Wide Association Of Gene Regions Controlling Selenium And Magnesium Accumulation In Walnuts (Juglans Regia L.), İrem Büyükalgan, Bülent Yağmur, Erdal Orman, Muhammed Bahatti̇n Tanyolaç, Duygu Ateş May 2025

Genome-Wide Association Of Gene Regions Controlling Selenium And Magnesium Accumulation In Walnuts (Juglans Regia L.), İrem Büyükalgan, Bülent Yağmur, Erdal Orman, Muhammed Bahatti̇n Tanyolaç, Duygu Ateş

Turkish Journal of Botany

Walnut (Juglans regia L.) is one of the most economically important species. It is of great importance to the food industry due to its nutritional value, and high content of many beneficial components such as macro and microelements. In the current study, the aim was to determine markers of single nucleotide polymorphism (SNP) associated with the gene(s) controlling the accumulation of Selenium (Se) and Magnesium (Mg) in walnuts. Se and Mg concentrations were measured in 154 genotypes of Juglans regia in 2021 and 2022. A total of 16,473 SNP markers were used for association mapping to analyze the marker-trait associations. …

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Complete Genome Analyses Of A Novel Narlivirus Identified In The Ectomycorrhizal Fungus Amanita Vidua, Ilgaz Akata, Eda Kumru, Gülce Edi̇ş, Ertuğrul Kaya, Ergi̇n Şahi̇n May 2025

Complete Genome Analyses Of A Novel Narlivirus Identified In The Ectomycorrhizal Fungus Amanita Vidua, Ilgaz Akata, Eda Kumru, Gülce Edi̇ş, Ertuğrul Kaya, Ergi̇n Şahi̇n

Turkish Journal of Botany

The widespread utilisation of deep sequencing has dramatically enhanced and revolutionised our understanding of virus diversity, particularly in complex environments such as soil and biological samples. This research explored mycovirus sequence analyses in the ectomycorrhizal fungus Amanita vidua, utilising deep sequencing alongside total double-stranded RNA (dsRNA) extractions. Our investigation unveiled a unique member of the proposed family, Narliviridae, designated as Amanita vidua narlivirus 1 (AvNV1), in an A. vidua specimen. AvNV1, classified under Amabiliviricetes, possesses a distinct genome structure and sequence attributes. T horough analyses indicated that AvNV1 exhibits sequence similarities with other mycoviruses from the proposed family Narliviridae and …

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Unveiling The Physical Interaction Between Gsnor1 And Trx-H Isoforms, Anika Tabassum, Gary J. Loake May 2025

Unveiling The Physical Interaction Between Gsnor1 And Trx-H Isoforms, Anika Tabassum, Gary J. Loake

Turkish Journal of Botany

This study aims to investigate any possible interaction between two highly conserved regulators of cellular SNO levels: S-nitrosoglutathione reductase (GSNOR1) and thioredoxin (TRX). These two enzymes control global S-nitrosylation levels and thus impact the cellular redox state during immune responses. A mutant line (Δtrx1trx2sfa1) of Saccharomyces cerevisiae MaV203 strain was generated to explore this possibility rather than using a classical strain. We identified and characterized the physical interaction between GSNOR1 and Arabidopsis cytosolic h isoforms in a yeast two-hybrid screen. Out of the seven TRX isoforms, AtGSNOR1 displayed a high interaction with AtTRXh3, AtTRXh4, and AtTRXh5 (AtTRXh5>AtTRXh4 & AtTRXh3). …

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Interlude 1: The Eternal Presence By Wifredo Lam, Mey-Yen Moriuchi May 2025

Interlude 1: The Eternal Presence By Wifredo Lam, Mey-Yen Moriuchi

PALARA: Publication of the Afro-Latin/American Research Association

No abstract provided.

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Acute Kidney Injury Triggers Hypoxemia By Lung Intravascular Neutrophil Retention That Reduces Capillary Blood Flow, Yohei Komaru, Liang Ning, Carine Lama, Anusha Suresh, Eirini Kefaloyianni, Mark J. Miller, Shinichi Kawana, Hailey M Shepherd, Wenjun Li, Daniel Kreisel, Andreas Herrlich May 2025

Acute Kidney Injury Triggers Hypoxemia By Lung Intravascular Neutrophil Retention That Reduces Capillary Blood Flow, Yohei Komaru, Liang Ning, Carine Lama, Anusha Suresh, Eirini Kefaloyianni, Mark J. Miller, Shinichi Kawana, Hailey M Shepherd, Wenjun Li, Daniel Kreisel, Andreas Herrlich

2020-Current year OA Pubs

Sterile acute kidney injury (AKI) is common in the clinic and frequently associated with unexplained hypoxemia that does not improve with dialysis. AKI induces remote lung inflammation with neutrophil recruitment in mice and humans, but which cellular cues establish neutrophilic inflammation and how it contributes to hypoxemia is not known. Here we report that AKI induced rapid intravascular neutrophil retention in lung alveolar capillaries without extravasation into tissue or alveoli, causing hypoxemia by reducing lung capillary blood flow in the absence of substantial lung interstitial or alveolar edema. In contrast to direct ischemic lung injury, lung neutrophil recruitment during remote …

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Label-Free Multimodal Optical Biopsy Reveals Biomolecular And Morphological Features Of Diabetic Kidney Tissue In 2d And 3d, Anthony A Fung, Zhi Li, Craig Boote, Petar Markov, Joseph P Gaut, Sanjay Jain, Lingyan Shi May 2025

Label-Free Multimodal Optical Biopsy Reveals Biomolecular And Morphological Features Of Diabetic Kidney Tissue In 2d And 3d, Anthony A Fung, Zhi Li, Craig Boote, Petar Markov, Joseph P Gaut, Sanjay Jain, Lingyan Shi

2020-Current year OA Pubs

Kidney disease, the ninth leading cause of death in the United States, suffers from poor diagnostic efficiency (10%). Traditional biopsies use molecular reagents to enhance diagnostic power but are limited by overlapping spatial and chromatic signals, product quality variability, and additional processing. To address these challenges without disrupting routine diagnostics, we implement label-free imaging modalities-stimulated Raman scattering (SRS), second harmonic generation (SHG), and two-photon fluorescence (TPF)-within a single setup. We identify morphological, lipidomic, and metabolic biomarkers in control and diabetic kidney samples at subcellular resolution. Label-free Stimulated Raman Histology (SRH) reveals distinct collagen morphology, mesangial-glomerular volumes, lipid saturation, redox status, …

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Modulation Of Her2 Internalization Enhances Single-Dose Antibody-Drug Potency In Her2+ Gastric Cancer, Abbey Zidel, Alex Benton, Emma Brown, Shayla Shmuel, Alex Vanover, Sandeep Surendra Panikar, Ron Bose, Haeseong Park, Andrew A Davis, Patrícia M R Pereira May 2025

Modulation Of Her2 Internalization Enhances Single-Dose Antibody-Drug Potency In Her2+ Gastric Cancer, Abbey Zidel, Alex Benton, Emma Brown, Shayla Shmuel, Alex Vanover, Sandeep Surendra Panikar, Ron Bose, Haeseong Park, Andrew A Davis, Patrícia M R Pereira

2020-Current year OA Pubs

HER2 is a membrane receptor tyrosine kinase overexpressed in 18-20% of gastric tumors. Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate (ADC) that targets HER2-positive (HER2

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Meningeal Lymphatics-Microglia Axis Regulates Synaptic Physiology, Kyungdeok Kim, Daviti Abramishvili, Siling Du, Zachary Papadopoulos, Jay Cao, Jasmin Herz, Igor Smirnov, Jean-Leon Thomas, Marco Colonna, Jonathan Kipnis May 2025

Meningeal Lymphatics-Microglia Axis Regulates Synaptic Physiology, Kyungdeok Kim, Daviti Abramishvili, Siling Du, Zachary Papadopoulos, Jay Cao, Jasmin Herz, Igor Smirnov, Jean-Leon Thomas, Marco Colonna, Jonathan Kipnis

2020-Current year OA Pubs

Meningeal lymphatics serve as an outlet for cerebrospinal fluid, and their dysfunction is associated with various neurodegenerative conditions. Previous studies have demonstrated that dysfunctional meningeal lymphatics evoke behavioral changes, but the neural mechanisms underlying these changes have remained elusive. Here, we show that prolonged impairment of meningeal lymphatics alters the balance of cortical excitatory and inhibitory synaptic inputs, accompanied by deficits in memory tasks. These synaptic and behavioral alterations induced by lymphatic dysfunction are mediated by microglia, leading to increased expression of the interleukin 6 gene (Il6). IL-6 drives inhibitory synapse phenotypes via a combination of trans- and classical IL-6 …

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Maintenance Of Graft Tissue-Resident Foxp3+ Cells Is Necessary For Lung Transplant Tolerance In Mice, Wenjun Li, Yuriko Terada, Yun Zhu Bai, Yuhei Yokoyama, Hailey M. Shepherd, Junedh M. Amrute, Amit I. Bery, Zhiyi Liu, Jason M. Gauthier, Marina Terekhova, Jon H. Ritter, Varun Puri, Ramsey R. Hachem, Maxim N. Artyomov, Kory J. Lavine, Ruben G. Nava, Andrew E. Gelman, Daniel Kreisel, Et Al. May 2025

Maintenance Of Graft Tissue-Resident Foxp3+ Cells Is Necessary For Lung Transplant Tolerance In Mice, Wenjun Li, Yuriko Terada, Yun Zhu Bai, Yuhei Yokoyama, Hailey M. Shepherd, Junedh M. Amrute, Amit I. Bery, Zhiyi Liu, Jason M. Gauthier, Marina Terekhova, Jon H. Ritter, Varun Puri, Ramsey R. Hachem, Maxim N. Artyomov, Kory J. Lavine, Ruben G. Nava, Andrew E. Gelman, Daniel Kreisel, Et Al.

2020-Current year OA Pubs

Mechanisms that mediate allograft tolerance differ between organs. We have previously shown that Foxp3+ T cell-enriched bronchus-associated lymphoid tissue (BALT) is induced in tolerant murine lung allografts and that these Foxp3+ cells suppress alloimmune responses locally and systemically. Here, we demonstrated that Foxp3+ cells that reside in tolerant lung allografts differed phenotypically and transcriptionally from those in the periphery and were clonally expanded. Using a mouse lung retransplant model, we showed that recipient Foxp3+ cells were continuously recruited to the BALT within tolerant allografts. We identified distinguishing features of graft-resident and newly recruited Foxp3+ cells and showed that graft-infiltrating Foxp3+ …

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Peripheral Neuroimmune Mechanisms Of Chronic Back Pain, Aleyah Esther Goins May 2025

Peripheral Neuroimmune Mechanisms Of Chronic Back Pain, Aleyah Esther Goins

Biomedical Sciences ETDs

Chronic back pain (CBP) affects 1 in 10 people worldwide, reducing mobility, productivity, and quality of life. Despite its prevalence, non-addictive treatments remain limited due to an incomplete understanding of chronic pain mechanisms. This dissertation examines peripheral neuroimmune interactions in CBP using a urokinase-type plasminogen activator (uPA)-induced mouse model (uPA-CBP). uPA, a pro-inflammatory serine protease, was injected into the L2/L3 lumbar spinous ligament, inducing prolonged mechanical and cold hypersensitivity. Flow cytometry of dorsal root ganglia (DRG) showed increased CD45+CD11b+ myeloid cells in males and CD45+CD3+CD4+ lymphocytes in females. DRG neurons from male uPA-CBP mice exhibited heightened action potential firing. Pharmacological …

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The Seed Pile Project - A Reflection, A. Haven Kiers, Caroline Larsen, Kate Hayes, Sahar Sadegh Malak Abadi, Ashley Hong, Billy Krimmel May 2025

The Seed Pile Project - A Reflection, A. Haven Kiers, Caroline Larsen, Kate Hayes, Sahar Sadegh Malak Abadi, Ashley Hong, Billy Krimmel

Cities and the Environment (CATE)

We conducted a community-science project in Northern California - the Seed Pile Project - with three broad goals: 1) to test which locally-native, seed-dispersed plants would thrive without intervention in human-occupied spaces, 2) to engage the public with the often-ignored biodiversity along our roadsides, sidewalks, and other highly-disturbed spaces, and 3) to create community around rewilding our urban areas. We conducted the project initially as a pilot project in 2020-2021, then as a community-science project in 2021-2022 and 2022-2023. The project design was intentionally simple to make it accessible for participants of all ages: participants received free packets of native, …

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Advancing Recovery Of Endangered San Joaquin Kit Foxes Through Urban Rewilding, Brian L. Cypher, Erica C. Kelly, Jaime L. Rudd May 2025

Advancing Recovery Of Endangered San Joaquin Kit Foxes Through Urban Rewilding, Brian L. Cypher, Erica C. Kelly, Jaime L. Rudd

Cities and the Environment (CATE)

San Joaquin kit foxes (Vulpes macrotis mutica) are endemic to arid habitats in the San Joaquin Valley region of central California. This species is listed as Endangered due to profound habitat loss throughout its range caused by agricultural, industrial, and urban development. Interestingly, kit foxes currently occur in three cities with the population in the city of Bakersfield being large (several hundred foxes) and self-sustaining. Demographic and ecological attribute values for this population are among the highest observed in San Joaquin kit fox populations. Loss of natural habitat is still occurring and additional urban kit fox populations could …

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Floral Use Competition Between Honey Bees And Bumble Bees Within An Urban Community, Taylor Kerekes, Sarah Mackell, Hadil Elsayed, Sheila Colla May 2025

Floral Use Competition Between Honey Bees And Bumble Bees Within An Urban Community, Taylor Kerekes, Sarah Mackell, Hadil Elsayed, Sheila Colla

Cities and the Environment (CATE)

The global increase in the number of managed honey bees (Apis mellifera) has raised concerns about their impact on native pollinator species, including bumble bees (Bombus spp.). This study examines the extent of floral resource overlap between honey bees and bumble bees in urban areas within the Greater Toronto Area (GTA), Ontario, Canada, to better understand how competition for floral resources may influence bumble bee foraging behavior and niche partitioning. Pollen samples were collected from 541 bees, representing seven Bombus species and honey bees, across ten urban sites with high vs low honey bee abundance. We analyzed …

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Independent- May 15, 2025, Leslie Lozada May 2025

Independent- May 15, 2025, Leslie Lozada

The Independent (1988-present)

No abstract provided.

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Dna Extraction And Species Determination Of Historic Museum Pelt Samples, Selin Ates May 2025

Dna Extraction And Species Determination Of Historic Museum Pelt Samples, Selin Ates

Student Theses

The identity of the fur covering the sculpture named Object in the Museum of Modern Art has remained a mystery since its creation in 1936 by Meret Oppenheim. DNA testing can possibly provide an answer, but to preserve the integrity of the sculpture, only a very small piece of the fur can be sampled. Prior to testing Object, testing using museum samples was performed to determine whether DNA of a sufficient quantity and quality can be extracted and sequenced. Several DNA extraction and sample washing methods were tested to examine the effects on the DNA of museum pelts aged …

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