Digital Commons Network^™

Heterozygous Kmt2d Loss Diminishes Enhancers To Render Medulloblastoma Cells Vulnerable To Combinatory Inhibition Of Lsd1 And Oxphos, Shilpa S Dhar, Calena Brown, Ali Rizvi, Lauren Reed, Sivareddy Kotla, Constantin Zod, Janak Abraham, Jun-Ichi Abe, Veena Rajaram, Kaifu Chen, Min Gyu Lee

Faculty, Staff and Student Publications

The histone H3 lysine 4 (H3K4) methyltransferase KMT2D (also called MLL4) is one of the most frequently mutated epigenetic modifiers in many cancers, including medulloblastoma (MB). Notably, heterozygous KMT2D loss frequently occurs in MB and other cancers. However, its oncogenic role remains largely uncharacterized. Here, we show that heterozygous Kmt2d loss in murine cerebellar regions promotes MB genesis driven by heterozygous loss of the MB-suppressor gene Ptch via the upregulation of tumor-promoting programs (e.g., oxidative phosphorylation [OXPHOS]). Downregulation of the transcription-repressive tumor suppressor NCOR2 by heterozygous Kmt2d loss, along with Ptch

Overcoming Nk-Mediated Rejection By Anti-3rd-Party Central Memory Veto Cd8 T Cells Through Downregulation Of Dnam-1 On Alloreactive Nk Cells, Wei-Hsin Liu, Aloukick Kumar Singh, Christa Blagdon, Sandeep Kumar Yadav, Einav Shoshan, Esther Bachar-Lustig, Yair Reisner

Faculty, Staff and Student Publications

Anti-3rd-party central memory veto CD8 T (veto Tcm) cells can overcome T cell-mediated graft rejection under mild conditioning without causing significant graft versus host disease (GVHD). We previously demonstrated that these veto Tcm cells can effectively delete anti-donor T cell clones through a Fas-FasL mechanism, whereas their ability to neutralize alloreactive natural killer (NK) cells and the mechanism of such potential activity remained unknown. Using “nude” mice as recipients of allogeneic T cell-depleted hematopoietic stem cell transplantation (HSCT), we demonstrate effective inhibition of NK-mediated rejection by Tcm cells. Ex vivo studies revealed that Tcm cells express high levels of CD155, …

A Systematic Review On Sentiment Analysis For Sindhi Text, Safdar Ali Soomro, Siti Sophiayati Yuhaniz, Mazhar Ali Dootio, Ghulam Murtaza, Muhammad Hussain Mughal

Baghdad Science Journal

The field of sentiment analysis has experienced significant growth in recent years due to its applications in various domains such as news headlines, online product purchase, marketing, and reputation management. With the rise of social media and online shopping platforms, there is a wealth use-generated data available. This has led manufacturing, sales, and marketing companies to seek global feedback on their practices and products from these sources. In the context of Sindhi language, millions of phrases are shared daily on news media sites, Twitter, Facebook, and other platforms. However, the exclusion of sentiment analysis for Sindhi language limits the utilization …

Analysis Of Multiple Working Vacations Queuing System With Encouraged Arrival Using M/M (A,B)/1 Model, P. Prakati, K. Julia Rose Mary

Baghdad Science Journal

Generally, it is very common in our daily life to meet up with queuing systems. This study examines the concept of encouraged arrival in M/M (a,b)/1/Multiple Working Vacations queuing model that follows the General Bulk Service Rule. The considered queuing model consists of three states namely idle, working vacation and regular busy period. The single server available in the system usually goes on vacation whenever the system is idle, that is, when it is empty. This model deals with multiple working vacations of the server which are exponentially distributed and the concept of encouraged arrival of the customers is examined …

On En-Prime Compactly Packed Acts Over Monoid, Samira Naji Kadhim, Uhood S. Al-Hussani, Muna Jasim Mohammed Ali

Baghdad Science Journal

This work studies the concept of En-prime compactly packed (𝐸𝑛−𝒫.𝒸.𝒫) modules. Some properties and characterizations have been studied. Put ₩ is an Я-module and every submodule is En-pure , then ₩ is 𝐸𝑛−𝒫.𝒸.𝒫 if and only if each proper submodule Ϣ of ₩ is cyclic, If ₩ is 𝐸𝑛−𝒫.𝒸.𝒫. ₩ which has at least one maximal submodule then ₩ satisfies the ACC on En-p-radical submodule. The generalization of this idea has been given for S-Acts. if for each family {Pα}α∈λ of En-prime subact of Д with Ѫ ⊆⋃Pαα∈λ, Ѫ⊆Pβ for some β∈λ. An S-Act Д is 𝐸𝑛−𝒫.𝒸.𝒫, if every subact …

A New Algorithm For Finding Initial Basic Feasible Solution Of Spherical Fuzzy Transportation Problem With Applications, K. Hemalatha, Venkateswarlu. B

Baghdad Science Journal

In operation research, a specific area being analyzed in great depth is the transportation problem (TP). The key objective of this problem is to find the lowest total transportation costs for commodities to meet consumer requirements at destinations incorporating resources acquired at their points of origin. In this work, the spherical fuzzy transportation problem (SFTP) determines the lowest cost of carrying items from origin to destination. Most of the time, accurate data has been used, but these variables are actually inaccurate and ambiguous. According to the literature, several generalizations and expansions of fuzzy sets have been proposed and investigated. One …

Stationary Distribution Of Stochastic Seirs Epidemic Model With Saturated Incidence Rate And Saturated Treatment Function, S. Saravanan, C. Monica

Baghdad Science Journal

This investigation aims to enhance and broaden the mathematical model that governs a dynamic stochastic SEIRS (Susceptible, Exposed, Infective, and Recovery) epidemic. This complex model integrates crucial components, including a saturated incidence rate and saturated treatment function, which are fundamental in molding epidemic dynamics. The objective is to explore the presence and uniqueness of a positive global solution through the application of a meticulously designed Lyapunov function, facilitating a more profound analysis of the intricacies of the systems. This analytical framework enables us to uncover the interactions among disease transmission, treatment dynamics, and stochastic influences. This theoretical framework assumes that …

Image Encryption Based On Chaotic Blocks Shuffling And Rc4, Donia Fadil Chalob, Rusul Hussein Hasan, Farah Neamah Abbas

Baghdad Science Journal

The necessity for image encryption has grown significantly, especially the rapid development of the Internet of Things (IoT) fast development and the ease with which images can be taken and transferred, including those related to travel, health care, the agricultural sector, the military and autos. Additionally, since every image has significant characteristics like size, high correlation, and massive redundant positions, encrypting it with a conventional key via IoT communication technology exposes it to numerous threats. Chaotic image cryptography is considered the most suitable method for image application due to its sensitivy to the initial conditions and control parameters. This research …

Towards An Efficient Internet Of Things Intrusion Detection By Using Support Vector Machine, Rawan Abo Zidan, George Karraz

Baghdad Science Journal

Intrusion Detection Systems (IDS) are crucial for safeguarding Internet of Things (IoT) networks against security threats. The integration of Support Vector Machine (SVM) with smart IDs has been a significant advancement in detecting anomalous activities. This research contributes to this field by implementing the Gaussian Pyramid (GP) algorithm, significantly reducing the processing amount and storage space required for large IoT network traffic datasets. This approach enables the GP model to classify thousands of data points in large-scale problems with high-dimensional input space. Notably, the GP model, with various kernel sizes, outperforms traditional nonlinear SVM and Artificial Neural Networks (ANN) in …

An Improved Deep Perceptual Hashing Algorithm-Based Information Retrieval System For Remote Cloud Computing, Othman Atta Ismael, Israa Fars Hassan

Baghdad Science Journal

The growth of information retrieval and associated services can be attributed to technical advancements. Meanwhile, traditional information retrieval methods are impacted by performance, accuracy, and scalability limitations. An information retrieval system for distant cloud computing that is based on an Improved Deep Perceptual Hashing Algorithm (IDP-HA) is one of the solutions that have been developed to solve these constraints. Systems are widely used due to their ability to recognize intricate patterns in data. The accuracy of information similarity measurement is still lacking due to the inherent complexity of data and measuring methods. The deep perceptual hashing approach uses Deep Neural …

Antibiofilm Properties Of 4-Hydroxy-3-Methyl-2-Alkenylquinoline, A Novel Burkholderia-Derived Alkaloid, Mckinley D Williams, Taylor R Sweeney, Sabrina Trieu, Ravi Orugunty, Abdelahhad Barbour, Fereshteh Younesi, Michael Glogauer, Nopakorn Hansanant, Ronald Shin, Shi-En Lu, Kevin Cao, Abraham Tenorio, Sigmund J Haidacher, Anthony M Haag, Thomas D Horvath, Leif Smith

Faculty, Staff and Students Publications

Biofilms are an important colonization mechanism employed by several microbial species to better establish themselves and monopolize the acquisition of resources across different environs. Some bacteria have evolved specialized metabolites that, when secreted, disrupt the formation and stability of biofilms generated by competing heterospecies, providing the producing organism with an ecological advantage. Soil-derived species are probable candidates for the identification of such compounds, given the intense level of competition that occurs within the terrestrial ecosystem. The MS14 strain of Burkholderia contaminans isolated from soil in Mississippi has previously been shown to produce antimicrobial compounds like occidiofungin and ornibactin. In this …

Modi‘In, Nofim Neighborhood: Animal Bones, Nimrod Marom

Qadum: Journal of Excavation Reports from Israel

This report describes a very small collection of animal bones from a karstic cave and an unfinished cistern excavated in Nofim Neighborhood in Modi‘in. It appears to comprise domesticated animals in secondary or tertiary deposition. Many of the bones represent donkeys and dogs, and therefore cannot be considered food refuse.

The Canadian Press Views The 1908 American Presidential Election, Harvey Strum

Journal of 20th Century Media History

"How many people appreciate the tragedy of the defeat of Mr. Bryan," asked the anti-Bryan Toronto World on 5 November 1908. This expression of sympathy for the Great Commoner's defeat by Republican candidate William Howard Taft, represented the opinion of a minority of the Canadian press. Newspapers representing western agrarian progressives, trade unions, militant Protestant nativists, independent reformers, and social reform Liberals regretted Bryan's defeat since he symbolized reform that might creep across the 49th parallel. If Bryan's third defeat did not prompt the majority of Canadian editors to dance in the streets it did prompt them to raise their …

1960s Teen Fan Magazines And The Beatles: An Exploration Of Community, Fandom, And The Beatles Narrative, Allison Bumsted

Journal of 20th Century Media History

In the 1960s, before the days of the internet, there were few places a young person could read about popular music – as a limited number of print media outlets took popular music, especially rock, seriously. In order to read about popular music (beyond the reprinting of lyrics, industry news, or promotions), one would turn to newly developed teen-type and teen fan magazines like DIG or 16 Magazine, where pages were full of artists such as Elvis, Annette, Leslie Gore, Connie Francis, and Paul Anka. In 1964, the teen fan magazine reached a new height with the arrival of …

“To Prepare The Mind For Wonder”: Popular Science And Mass Media In The 1920s, Alexander Olson

Journal of 20th Century Media History

This article examines the creation and development of the Science Service, a 1920s initiative aimed at popularizing science through mass media. Founded by biologist William Ritter and newspaper magnate Edward Scripps, the wire service sought to disseminate accurate scientific information to the American public via newspapers, radio, and other popular media. While Scripps favored a commercially viable, accessible style that used entertainment to hook readers, Ritter envisioned science journalism as a tool for democratic education and intellectual empowerment. These conflicting philosophies created lasting tensions within the organization around how to address challenges such as sensationalism, editorial independence, and public skepticism. …

A Digital Pixel Sensor Having Decreased Pixel Size

Defensive Publications Series

A pixel array includes a photodiode array and an ADC-memory array underlying the photodiode array, where the photodiode array includes a plurality of photodiode groups, and each photodiode group shares a common ADC element from within the ADC-memory array.

Automatonophobia, Adrian Bruch

Staff Scholarship - Australia & Dubai

These artworks were created as a direct result of my teaching the ANI216 Animation Studio. In the process of devising ways to incorporate photographic imagery into an animation, I developed a multi-plane system where I could create layers in Adobe Photoshop and combine them with original cartoon characters in After Effects and then animate them.

These artworks for an exhibition at the Garden Gallery (Royal Botanic Gardens, Sydney) are imaginary stills inspired by the actual animation. All three were sold.

Tickborne Colpodella Species Infections: Time For A New Integrated Approach To Understand Transmission And Pathogenicity, T. Y. Sam-Yellowe, Trinity Nims, Sona Qaderi, Mary M. Asraf

Biological, Geological, and Environmental Faculty Publications

Colpodella species are free-living predatory protists that prey on algae, ciliates and bodonids using myzocytosis. Colpodella species have been reported in human and animal infections. Polymerase chain reaction (PCR) using primers targeting 18S rRNA genes of Cryptosporidium and piroplasms have identified Colpodella species in arthropods, host blood and feces, demonstrating the phylogenetic closeness of Colpodella species to the apicomplexa. However, in human, animal and arthropod hosts, the life cycle stages of Colpodella are unknown. In this literature review, we provide an overview of the widespread occurrence of Colpodella species in ticks, and pathogenicity in humans and animals. We discuss methods …

Oberlin College Commencement 2025, Oberlin College

Commencement Programs

No abstract provided.

An Exploration Of The Impact Of Educational Background On Basic Science And Life Sciences Librarians, Laura Lipke, Margaret Hoogland, Jeremy Kupsco, Stephanie Schulte

Library Scholarship

This study sought to investigate the influence of a science educational background on librarian interactions with basic and life sciences programs. Through semi-structured interviews with 14 librarians, the study identified several key themes: understanding and enjoying science is beneficial; previous experience influences librarians’ approaches; relationships are important; defining success is challenging; and collaborating with other campus units is unusual. Results suggest a science undergraduate or graduate degree and previous science-related work experience enhance librarians’ comfort and communication with scientists and highlight a lack of professional continuing education related to researcher workflows.

Unpacking Violence: Examining Socioeconomic, Psychological, And Genetic Drivers Of Gun-Related Homicide And Potential Solutions, John Menezes, Kavita Batra

Department of Plastic Surgery Faculty Research

Background: Gun-related homicide remains a persistent public health crisis in the United States, with over 48,000 firearm-related deaths reported in 2022, including 19,651 homicides and 27,032 suicides. Despite frequent calls for tighter gun control, firearm access alone does not explain the complexity of violence. Objective: This commentary aims to unpack the socioeconomic, psychological, and biological drivers of gun-related homicide and propose integrative, evidence-based solutions that extend beyond legislative reform. Methods: We synthesized data from peer-reviewed literature, national crime and health databases (e.g., Centers for Disease Control and Prevention and Federal Bureau of Investigation), and international reports. We examined patterns related …

Dna Repair And The Contribution To Chemotherapy Resistance, Ksenija Nesic, Phoebe Parker, Elizabeth M Swisher, John J Krais

2020-Current year OA Pubs

The DNA damage response comprises a set of imperfect pathways that maintain cell survival following exposure to DNA damaging agents. Cancers frequently exhibit DNA repair pathway alterations that contribute to their intrinsic genome instability. This, in part, facilitates a therapeutic window for many chemotherapeutic agents whose mechanisms of action often converge at the generation of a double-strand DNA break. The development of therapy resistance occurs through countless molecular mechanisms that promote tolerance to DNA damage, often by preventing break formation or increasing repair capacity. This review broadly discusses the DNA damaging mechanisms of action for different classes of chemotherapeutics, how …

Wildlife Road Mortalities During Covid-19 Pandemic-Related Lockdown In South Texas: A Comparative Survey, Bradley Evan Beer, Kevin W. Ryer, Md Saydur Rahman, John H. Young Jr., Richard J. Kline

School of Earth, Environmental, & Marine Sciences Faculty Publications

Mortalities of wildlife caused by collisions with vehicles along roads are increasing in prevalence, threatening the existence of various species and populations. The COVID-19 pandemic-related lockdown provided an opportunity to gain a better understanding of how wildlife vehicle mortality occurrences change in response to anthropogenic variables and how varying survey methods influence obtaining mortality data. In this study, data were collected in three observation periods: pre-lockdown (PreL), during lockdown (DL), and post-lockdown (PostL) in south Texas. There were 194 wildlife mortalities recorded during weeks 4–27 of 2020. Results of this study showed that road mortality survey counts did not change …

The Impact Of Narratives And Active Video Games Among Black And Hispanic Children With Overweight And Obesity: A Randomized Controlled Trial, Amy S Lu, Tom Baranowski, Tiago V Barreira, Amy Fleischman, Melanie C Green, Shirley Y Huang, I-Min Lee, Lynne L Levitsky, Farzad Noubary, Debbe Thompson

Children’s Nutrition Research Center Staff Publications

Background: Overweight and obesity disproportionately affect Black and Hispanic children who also play more video games. Narratives, coupled with home-based active video games (AVGs), may enhance PA and mitigate these disparities. This study tested the effect of narrative-enhanced home-based AVGs among predominantly Black and Hispanic children with overweight and obesity.

Methods: This 6-month three-group RCT recruited 135 children aged 7-14 from pediatric clinics in Boston, MA (January 2020 - May 2022) during the COVID-19 pandemic. Participants were randomized into: [Narrative + AVG], receiving an Xbox/Kinect with six AVGs interspersed with a narrative animation Ataraxia (72 episodes over six months), which …

Scaling Up Eco-Engineering: The Role Of Topographic Complexity And Spatial Variability In Shaping Biodiversity On Coastal Structures, Charlotte Clubley, Antony Knights, Jessica Allen, David T Bilton, Andy Foggo, Mick Hanley, James Murphy, Louisa E Wood, Louise Firth

School of Biological and Marine Sciences

In response to the depauperate biodiversity often associated with the largely homogenous surfaces of artificial structures, ecological (eco-) engineering has emerged as a tool to introduce topographic complexity to coastal development. Although relatively small-scale studies using topographically complex panels and artificial rockpools are commonplace, determining how the configuration of these interventions works over greater and more realistic spatial scales has received comparatively little attention. Given the importance of spatial variability in habitat complexity for shaping community composition and, therefore, regional diversity, filling this knowledge gap is key to enhancing the ‘design catalogue’ for future eco-engineering installations. Here, we manipulated topographic …

A Quantum Reservoir Computing Approach To Computer-Aided Music Composition, Eduardo Miranda, Hari Shaji

School of Art, Design and Architecture

This paper presents an approach to developing computer-aided music composition (CAMC) systems with quantum computing. CAMC systems are aimed at supporting musicians in creating music rather than generating complete pieces of music autonomously. For instance, they may generate ideas or prompts to be further developed during the creative process. We developed a CAMC system using a machine learning method called Quantum Reservoir Computing (QRC) that learns to create tunes in the style of given examples. The system proved to run satisfactorily on the Noisy Intermediate-Scale Quantum (NISQ) machines available today. It does not require large amounts of qubits to outperform …

Developing A Murine Model To Investigate The Mechanisms Of Peanut, Cashew, Shrimp Multifood Allergy, Aaron Wilson

NYMC Student Theses and Dissertations

Approximately 32 million people in the United States have food allergies, which is approximately 10 percent of the population. Food allergies can be mild, moderate, or even severe, resulting in anaphylaxis. The most predominant food groups that trigger food allergies include peanuts, tree nuts, fish, and shellfish. Peanuts and tree nuts have some similarities in protein structure. Shellfish is not associated with the protein properties of peanuts or tree nuts, it is the leading cause of adult anaphylaxis and often co-exist with peanut and tree nut allergies Currently, there are few studies that have established a murine model for allergy …

The Next Four Years: Geographical Reflections On The Second Trump Administration, Caroline R. Nagel, Peter Hopkins

Faculty Publications

In this introductory essay, we reflect on the significance of the re-election of Donald Trump to the presidency in the United States, and we provide some context for interpreting Trump's second term. Two of Trump's early policy moves—the release of billions of gallons of water from reservoirs in California and the granting of refugee status to Afrikaners—portend four years of politics based on alternative facts, conspiracy theories, and racial grievances. Trump's political agenda has received a significant boost from Silicon Valley billionaires, who are keen to eliminate regulatory bureaucracy. Paradoxically, while allied with high-tech futurists, Trump's policies hearken to an …

Against Attorney General Self-Referral In Immigration Law, Stella Burch Elias, Paul Gowder

Minnesota Law Review Vols. 106:2 onward (2021-present)

This Article advances a rule-of-law-based critique of the Attorney General’s immigration self-referral power. We argue that the Attorney General’s self-referral and review power over pending immigration proceedings allows an appointed Executive Branch official to engage in unchecked and unilateral lawmaking and, therefore, should be abolished. Scholars have typically understood legal stability, prospectivity, and the separation of policymaking from adjudication as requirements of the Anglo-American rule of law regime which protect individual freedom and equality. It is traditionally believed that by limiting policy-driven legislation to prospective, general laws which are enacted through an explicitly legislative process, individuals may be secure against …

No Escape From Microplastics: Contamination Of Reef Manta Ray Feeding Areas In A Remote, Protected Archipelago, Jessica Savage, Joanna Harris, Heather J. Koldewey, Tom B. Letessier, M Rowcliffe, D Morritt

School of Biological and Marine Sciences

Remote islands receive plastic debris from elsewhere, ranging from microplastics (>5 mm) to macroplastics, which can further breakdown into microplastics. The ingestion of microplastics by marine species has been linked to decreased fitness. Reef manta rays, Mobula alfredi, are liable to ingest microplastics due to their filter-feeding strategy and habitat overlap with plastic hotspots. Their population is in decline due to unsustainable fishing pressures and a slow life history, with potential additional demographic pressure from plastic pollution. This study investigates the concentration and characteristics of microplastics in the top 0.5 m of the water column in reef manta rays …