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The Immeasurable Value Of Plankton To Humanity, Maria Grigoratou, Susanne Menden-Deuer, Abigail Mcquatters-Gollop, George Arhonditsis, Luis Felipe Artigas, Sakina-Dorothée Ayata, Dalida Bedikoğlu, Beatrix E Beisner, Bingzhang Chen, Claire Davies, Lillian Diarra, Owoyemi W Elegbeleye, Jason D Everett, Tatiane M Garcia, Wendy C Gentleman, Rodrigo Javier Gonçalves, Tamar Guy-Haim, Svenja Halfter, Jana Hinners, Richard R Horaeb, Jenny A Huggett, Catherine L Johnson, Maria T Kavanaugh, Ana Lara-Lopez, Christian Lindemann, Celeste López-Abbate, Monique Messié, Klas Ove Möller, Enrique Montes, Frank E Muller-Karger

School of Biological and Marine Sciences

Plankton, a diverse group of aquatic organisms, make Earth livable, regulate aquatic life, and provide benefits to human societies such as access to clean water, food security, and well-being. They also support economies and inspire biotechnological innovations. This article aims to raise awareness of the value of plankton to humanity and serves as an informative guide for aquatic professionals, policymakers, and anyone interested in plankton. We present the value of plankton across six themes of human interest: biogeochemistry; ecology; climate; the evolution of science; economy; and culture, recreation, and well-being. Guided by the 2022 Intergovernmental Science-Policy Platform on Biodiversity and …

Rezafungin Versus Caspofungin For The Treatment Of Candidemia And Invasive Candidiasis: Results From The Double-Blind, Randomized, Phase 3 Restore Trial Including The China Extension Study, George R Thompson, Haihui Huang, Sizhou Feng, Yunsong Yu, Alex Soriano, Oliver A Cornely, Bart Jan Kullberg, Peter G Pappas, Marin Kollef, Jose A Vazquez, Patrick M Honore, Laura Cox, Matteo Bassetti

2020-Current year OA Pubs

BACKGROUND: Rezafungin is approved for use in adults with candidemia and/or invasive candidiasis (IC) based on data from the ReSTORE trial (NCT03667690), which demonstrated noninferior efficacy to caspofungin. For regulatory purposes, an additional cohort of patients from China was recruited to ReSTORE. Here, we compared rezafungin and caspofungin in patients with candidemia and/or IC through analysis of the ReSTORE global data plus the China extension study.

METHODS: Adults with candidemia/IC were randomized (1:1) to receive weekly rezafungin (400/200 mg) or daily caspofungin (70/50 mg) for ≤28 days. Noninferiority was concluded for primary efficacy endpoints if the upper bound of the …

Antimicrobial Resistance Of Clostridioides (Clostridium) Difficile In Cambodia, Lengsea Eng, Papanin Putsathit, Su Chen Lim, Jessica M. Chisholm, Deirdre A. Collins, Archie C.A. Clements, Kefyalew Addis Alene, Thomas V. Riley

Research outputs 2022 to 2026

Background/Objectives: Antimicrobial resistance (AMR) remains a major topic of interest in infectious disease management. We studied AMR in Clostridioides difficile isolated in Cambodia. Methods: Agar dilution susceptibility testing was performed according to the CLSI guidelines to determine minimal inhibitory concentrations (MICs) of 10 antimicrobials for 192 isolates of C. difficile from four populations in Cambodia: hospitalised adults, hospitalised children, children from an outpatient department (OPD), and healthy adolescents in the community. Results: Using the CLSI MIC breakpoints for anaerobes and EUCAST breakpoints for C. difficile, all isolates were susceptible to vancomycin, metronidazole, fidaxomicin, and amoxicillin/clavulanic acid, and none were resistant …

Comparison Of Decision-Making Skill In 360° Video To The Field Setting In Highly Skilled Rugby Union Players, Hannah J. Vawser, Khaya Morris-Binelli, Benjamin Piggott, Sean Müller, Paola Chivers, Evan Dekker

Research outputs 2022 to 2026

Little evidence exists of whether decision-making in immersive 360° video is representative of the field setting in sport. The purpose of this study was to investigate whether decision-making performance of a representative exemplar competition specific skill was similar between 360° video and a field task. Fifteen players from skilled junior rugby union pathways and professional rugby union teams in Australia were recruited to complete a 360° video decision-making choice response task involving four attackers and three defenders. Their decision-making was previously assessed in a similar field decision-making task that was representative of rugby game play. Decision-making was scored according to …

Resource Assessment Report No. 4: North Coast Demersal Scalefish Resource - Kimberley 2025 Assessment, Fabian Trinnie, Rubie Evans-Powell, Ainslie Denham, Sybrand A. Hesp, Corey Wakefield, Craig L. Skepper, Brett Crisafulli, Stephen J. Newman

Resource Assessment Reports

The North Coast Demersal Scalefish Resource (NCDSR) comprises ecological suites of tropical demersal fish species that occur predominantly in inshore waters (20–250 m deep) and offshore waters ( > 250 m deep) of the North Coast Bioregion (NCB). More than 60 demersal species are landed by fisheries operating in the Kimberley and Pilbara regions of the NCB each year, including high-value snappers (Lutjanidae), groupers (Epinephelidae), and emperors (Lethrinidae). As outlined in the NCDSR Harvest Strategy (DPIRD, 2017), the Kimberley resource is currently monitored through annual reviews of total removals and catch rate trends of indicator species, as well as periodic (every …

Vol. 28, No. 2: Masthead, Water Law Review

Water Law Review

No abstract provided.

Dammed, Diverted, & Dry: The Colorado River Delta Deserves A Chance, Davin Roark

Water Law Review

Over the last century, dams and diversions on the Colorado River have devastated the Colorado River Delta and the Sea of Cortez-a crisis exacerbated by climate change. While Minutes 319 and 323 of the 1944 Treaty between the United States and Mexico have achieved some success, they have failed to adequately protect or restore the ecosystem in the face of our changing climate. The research is clear: the Delta continues to be in serious trouble. As Minute 323's expiration rapidly approaches, negotiations regarding its successor are ongoing. The International Boundary and Water Commission (IBWC) has the power to ensure this …

The Mercy Seat Of The Risen Christ: Atonement And The Glory Of God In Romans 3:21-26, David Westfall

Faculty Work Comprehensive List

Scholarship on Romans 3.21–26 typically isolates the death of Jesus on the cross as the moment when Paul says the righteousness of God was disclosed, leading to the justification of all who believe the gospel. In this paper I argue that, although the death of Christ relates in important ways to Paul’s claims in the paragraph, this reading does not fully account for his metaphorical description of Christ as a ‘mercy seat’ (ἱλαστήριον), nor his assertion that those who believe are ‘justified through the redemption that is in Christ Jesus’. I show that Paul uses this language and imagery to …

Impact Of Varied Dietary Macronutrient Ratios On The Nutrition Status Of Swiss Albino Mice, Hellen Kinyi, Charles Kato, Gertrude Kiwanuka

Biomedical Sciences, East Africa

The nutrition status of an organism depends on the balance between nutrient intake and utilization. Malnutrition results not only from inadequate caloric intake but also from imbalanced macronutrient ratios, which can affect aging, metabolism, and health. While many studies focus on individual nutrients, this study used purified, isocaloric diets with varying macronutrient ratios to assess dietary effects on nutrition markers in Swiss albino mice.

Mice were randomized into 6 dietary groups, each containing 6 males and 6 females housed separately. Each group received an isocaloric diet with different carbohydrate, protein, and lipid ratios for 15 weeks. Animal weight, body mass …

Docking Investigation Of Thevetia Peruviana Plant Compounds For Targeting Molluscicidal Activity Against Biomphalaria Alexandrina Snails, The Intermediate Host Of Schistosoma Mansoni, Samah I. Ghoname, Basma H. Amin, Asmaa T. Mohamed, Olfat A. Olfat A. Hammam, Hebat‑Allah A. Dokmak

Nanotechnology Research Centre

Background Thevetia peruviana, commonly known as Yellow Oleander or Cabbage Tree, is a tropical shrub. Extracts from various parts of the plant (e.g., leaves, seeds) have demonstrated pesticidal properties, including the ability to repel or kill intermediate hosts of Schistosomiasis. Methods This study employed gas chromatography–mass spectrometry (GC–MS) analysis to identify 33 compo nents in the ethanol extract, with key compounds exhibiting antioxidant, anti‑inflammatory, anticancer, and anti microbial properties. Additionally, the research investigated the molluscicidal activity of the plant extract, its impact on Caspase‑3 expression, steroid sex hormone levels in Biomphalaria alexandrina, and histological alterations in the digestive and hermaphrodite …

"Ai" (Artificial Intelligence) Evidence: Rather Than Struggling To Decide Whether To Classify A Methodology As "Ai" And Relying On A Generalization About Ai Evidence, The Court Should Inquire Whether The Expert's Methodology Possesses A Specific Characteristic That Is Problematic In An Evidentiary Sense, Edward J. Imwinkelried

Hofstra Law Review

No abstract provided.

Article Xx And The Competition Problem: How The Justice Department Could Revive The Labor Movement By Suing The Afl-Cio, Alexander Macdonald

Hofstra Law Review

No abstract provided.

Wildlife Connectivity And Its Relationship With Vehicle Collision Hotspots Across New Hampshire, Clara Dawson

Master's Theses and Capstones

Chp. 1: Road networks fragment wildlife habitat and impede wildlife connectivity, which leads to elevated wildlife-vehicle collision (WVC) risk and increased danger to humans and wildlife. Habitat connectivity has been linked to WVC hotspot location and intensity, but this relationship likely depends on landscape context and road characteristics, which may be nonlinear due to varying habitat availability. Our objective was to evaluate factors affecting WVC location and intensity across New Hampshire, USA, with a focus on habitat connectivity. We assessed the relationship between WVCs and five connectivity models using generalized additive models and compared connectivity effects to road and land …

Toxin-Producing Cyanobacteria In Green Manure Microbiomes, Alyssa Nicole Daigle

Master's Theses and Capstones

The increasing reliance on inefficient synthetic fertilizers, which readily leach from soils and contribute to downstream pollution, underscores the urgent need for more sustainable nutrient sources, such as green manures (GMs). Floating aquatic plants like duckweeds are particularly promising candidates due to their natural abundance, rapid growth rates, and ability to efficiently uptake nutrients. However, the presence of toxin-producing cyanobacteria in duckweed microbiomes raises concerns about the potential for toxin accumulation, like microcystins (MCs), both in the GM biomass and in the edible crops to which it is applied. To evaluate the suitability and safety of duckweed-based GMs, we conducted …

Evaluating The Influence Of Landscape Structure On Blanding’S Turtle (Emydoidea Blandingii) Home Range Size, Maeve Grace Kelley

Master's Theses and Capstones

Freshwater turtles are increasingly threatened by anthropogenic activities that fragment critical habitats and impede movement across the landscape. The Blanding’s turtle (Emydoidea blandingii), a species that undergoes frequent interwetland movements, is particularly vulnerable to road mortality when natural habitats are disturbed or converted. Understanding the spatial ecology of this species is essential to inform effective conservation and management strategies. This study examined how landscape structure (composition and configuration) influences Blanding’s turtle home range size. Home range and core areas were modeled during the active season and separately for two distinct activity periods (nesting and post-nesting) using radio-telemetry data collected across …

Host Evolutionary History As A Predictor Of Microbiome Breeding Success, Ciana Lazu

Master's Theses and Capstones

Microbial inoculants present a potential alternative to artificial fertilizers and other chemical products in agriculture, yet microbial products derived from non-native microbes may pose ecological risks or fail to thrive. On the other hand, creating microbial inoculants from local microbes via “microbiome breeding” can be unpredictable. Here, the aquatic plant Lemna minor (duckweed), microbes isolated from duckweed, and microbes isolated from other, co-occurring aquatic plants was used to evaluate if the evolutionary distance between hosts from which microbes are sourced is a predictor of the success in “breeding” locally derived microbiomes to promote duckweed growth. “Microbiome breeding” was performed on …

The Role Of Liver Macrophages In Viral Liver Pathogenesis, Alexis Brantly, Kyle Yeakle, Michael J. Bouchard, Peter J. Gaskill, Michael R. Nonnemacher

Kimmel Cancer Center Faculty Papers

Liver macrophages play important roles in the pathophysiology of liver fibrosis and hepatocellular carcinoma. However, liver macrophages are a heterogenous population and have differing roles in maintenance of liver function and response in disease. In a healthy liver, macrophages play a critical role in antigen processing, maintaining tolerance to the high levels of gut-derived bacterial products, and regulating inflammation through cytokine response. However, macrophages also play a critical role in liver pathology, specifically in the context of viral infection. The liver is targeted by multiple viruses, including human immunodeficiency virus, hepatitis B virus, and hepatitis C virus, which dysregulate macrophage …

Evaluating Early Successional Habitat Selection By Herpetofauna And Pygmy Rattlesnakes In Tennessee, Carlin Frost

Tennessee State University Alumni Theses and Dissertations

Coupled with climate change, global biodiversity declines are exacerbated by increasing anthropogenic pressures and ecosystem destruction. Amphibians and reptiles are particularly vulnerable due to their specific and narrow habitat requirements. In Tennessee, the Western Pygmy Rattlesnake (Sistrurus miliarius streckeri) is classified as Threatened and is primarily associated with floodplains adjacent to early successional habitats (ESH) in the western Interior Plateau ecoregion. These ESH support unique flora and fauna but have declined in recent decades, largely due to urban encroachment and disturbance suppression. Studying snakes is challenging because of their limited activity periods, small home ranges, and low detectability from cryptic …

Procedures For Rangeland Condition Assessment In The Pilbara And Southern Rangelands 2025, Department Of Primary Industries And Regional Development, Western Australia

Natural resources published reports

This report defines the procedures used in 2025 by DPIRD to complete rangeland condition assessment (RCA) in the Pilbara and southern rangelands region which has predominantly shrub-based pastures. For the rest of the pastoral estate, DPIRD uses the Procedures for RCA in the Kimberley which has grass pastures.

RCA is the process DPIRD uses to make systematic, station-level assessment of rangeland. Rangeland condition considers both the condition of pastures (defined in the ‘Pasture condition guides for the Pilbara’ and ‘Pasture condition guides for the southern rangelands including the Gascoyne, Murchison and Goldfields-Nullarbor’) and soils as determined by erosion, using the …

Procedures For Rangeland Condition Assessment In The Kimberley 2025, Department Of Primary Industries And Regional Development, Western Australia

Natural resources published reports

This report defines the procedures used in 2025 by DPIRD to complete rangeland condition assessment (RCA) in the Kimberley region which has grass-based pastures. For the rest of the pastoral estate, DPIRD uses the Procedures for RCA in the Pilbara and southern rangelands which have predominantly shrub pastures.

RCA is the process DPIRD uses to make systematic, station-level assessment of rangeland. Rangeland condition considers both the condition of pastures (as defined in the 'Pasture condition guide for the Kimberley') and soils as determined by erosion, using the erosion assessment method on pastoral lands in Western Australia. The methods have evolved …

Who Is The God "With Whom We Have To Do"?, Michael Williams

Pro Rege

No abstract provided.

Inyoni And The Pale Man (Book Review), James C. Schaap

Pro Rege

Reviewed Title: Inyoni and the Pale Man by John Suk. Bloomington, IN: Archway Publishing, 2025. 256 pp. ISBN: 9781665770194.

Mechanistic Insights Into The Neuroprotective Effects Of The Antidepressant Agomelatine In Alzheimer's Disease, Grace Terry

Dissertations, Theses, and Capstone Projects

Alzheimer’s Disease (AD) is a complex neurodegenerative disease that has limited treatment options and no cure. AD is characterized by robust pathology including extracellular amyloid beta plaques, intracellular neurofibrillary tangles, neuronal and synaptic loss, neuroinflammation, and brain atrophy. AD presents with cognitive decline and memory loss but only years after neuropathology has started to accumulate. This robust pathology has made AD difficult to treat and highlights the need for therapeutics that modulate multiple pathways. Agomelatine (AGO) was selected by a high-throughput machine learning drug repurposing algorithm by our collaborator Dr. Lie Xie (Hunter College Dept. of Comp. Sci.) as having …

Investigating The Role Of Early Growth Response 1 (Egr1) Gene In Riluzole-Induced Apoptosis In Osteosarcoma, Syeda Maryam Azeem

Dissertations, Theses, and Capstone Projects

Osteosarcoma is a rare but aggressive bone malignancy most commonly affecting adolescents and young adults (AYA). With 5-year survival rate stagnating over the last four decades despite the advancements in multi-modal therapy, drug repurposing offers a rapid path to new osteosarcoma treatments. Recent studies suggest that Riluzole, a drug approved for amyotrophic lateral sclerosis (ALS), may be repurposed for osteosarcoma treatment due to its ability to slow tumor progression and induce apoptosis. Previously, we have shown that Riluzole increases reactive oxygen species (ROS), activating c-Abl, which phosphorylates YAP in the nucleus. YAP then forms a complex with p73 to enhance …

Behavioral Biomarkers Of Vulnerability In The Aba Model, Nora Ozer

Dissertations, Theses, and Capstone Projects

Anorexia nervosa (AN) is a severe psychiatric disorder with the highest mortality rate among mental health conditions, yet effective biological treatments remain limited. The activity-based anorexia (ABA) paradigm, which combines food restriction with wheel access to model the hyperactivity and self-starvation cycle characteristic of AN, shows considerable individual variability in vulnerability. Understanding what predisposes certain individuals to develop the full ABA phenotype while others remain resilient could inform early intervention strategies for human AN. This study employed continuous behavioral monitoring technology to identify early predictors of vulnerability to activity-based anorexia in mice, with the goal of discovering behavioral biomarkers that …

Interspecies Responsivity In Early Modern Drama And Animal Performances, Taylor C. Culbert

Dissertations, Theses, and Capstone Projects

This dissertation proposes an expansive, interspecies definition of performance that uses behavior rather than cognition as the decisive feature and illustrates how such a definition can reshape our approach to theatre and performance history. Using the concept of responsivity, which refers to the embodied and affective ways that humans and non-human animals acknowledge and react to one another, I trace human–animal interactions across a variety of sixteenth- and seventeenth-century performance genres, from the aristocratic stag hunt and entertainments involving trained animals to the plays of Molière and Shakespeare. Drawing on my experience training animals, I offer a new perspective on …

The Crisis Of Safety, Well-Being, And Belonging Facing Lgbtq Children: Mad/Crip Of Color Critique Towards A Curriculum Of Radical Care, Jameson Goetz

Dissertations, Theses, and Capstone Projects

In this thesis, I turn toward the study of educational experience, defined broadly to include lived experiences both within and outside of formal schooling institutions. I approach curriculum as an ongoing project of self-understanding in which one becomes mobilized for engaged pedagogical action alongside others in the pursuit social justice. I am guided by the following question, foundational to the field of curriculum studies: for those of us who work alongside LGBTQ children, what knowledge is of most worth? Critically reflecting on ways of working alongside LGBTQ children in the pursuit of social justice, I formulate a mad/crip of color …

Investigation Of Motor Neuronal And Circuit Level Mechanistic Determinants Of Spinal Excitability Following Cst Injury, Thelma Bethea

Dissertations, Theses, and Capstone Projects

The corticospinal tract (CST) is the primary descending motor pathway in mammals, essential for precise, dexterous movements, especially in humans and nonhuman primates. Damage to the CST, such as from spinal cord injury (SCI), impairs skilled motor function and triggers maladaptive changes including aberrant proprioceptive afferent sprouting and increased spinal excitability. These changes are closely linked to both muscle weakness and the development of hyperreflexia, compounding the functional deficits. Animal models of SCI are valuable for investigating mechanisms of injury and recovery, though traditional models often limit the ability to isolate circuit-specific contributions. To address this, I employed selective unilateral …

The Evolution And Reproduction Of Andean Miconia (Melastomataceae), Juan Angulo

Dissertations, Theses, and Capstone Projects

Understanding the factors that shape diversification and distribution in tropical plant lineages is central to explaining the origins of Neotropical biodiversity. Assessing evolutionary history with trait evolution and climatic niche dynamics provides key insights into the drivers of diversification and biogeography, while natural history data remains critical for these evolutionary studies. The Tropical Andes, with its exceptional biodiversity and environmental heterogeneity, offers an ideal setting to explore these processes. In this dissertation, I investigate how reproductive systems, climatic niche dynamics, and pollination strategies influence the evolution and biogeography of Miconia III, a large and ecologically diverse clade in the …

Low-Resource Ecoacoustic Audio Classification, Enis Berk Coban

Dissertations, Theses, and Capstone Projects

Ecoacoustic monitoring via machine learning enables scalable analysis but is often constrained by labeled data scarcity, particularly in remote regions like the Arctic. This thesis confronts low-resource ecoacoustic audio classification by developing and evaluating complementary machine learning methodologies. We introduce EDANSA, the first publicly available, expert- labeled Arctic dataset of its kind, curated via novel active learning, alongside a baseline CNN. We systematically evaluate transfer learning, showing general audio embeddings effectively bootstrap classifiers for challenging Arctic sounds, significantly outperforming direct label mapping. Optimizing label utility, we investigate standard data augmentation and introduce novel audio data valuation via Shapley values, revealing …