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Articles 18781 - 18810 of 732791
Full-Text Articles in Entire DC Network
Development Of A Water Temperature Modeling Platform To Support Short- And Long-Term Water Temperature Management In Reservoir-River Systems, Michael Deas, Yung-Hsin Sun, John Degeorge, Benjamin T. Saenz, Thomas A. Evans, Scott Burdick-Yahya, Stephen Andrews, Jeff Schuyler, William Candy, Lin Zheng, Scott Wells, Multiple Additional Authors
Development Of A Water Temperature Modeling Platform To Support Short- And Long-Term Water Temperature Management In Reservoir-River Systems, Michael Deas, Yung-Hsin Sun, John Degeorge, Benjamin T. Saenz, Thomas A. Evans, Scott Burdick-Yahya, Stephen Andrews, Jeff Schuyler, William Candy, Lin Zheng, Scott Wells, Multiple Additional Authors
Civil and Environmental Engineering Faculty Publications and Presentations
The U.S. Department of the Interior, Bureau of Reclamation (Reclamation) supports water temperature management for fishery species protection in downstream river reaches below Central Valley Project (CVP) reservoirs in the Sacramento, American, and Stanislaus River systems. The Water Temperature Modeling Platform (WTMP) Project was initiated to modernize and enhance modeling capabilities to predict summer–fall water temperature through reservoir cold water pool management using temperature control facilities designed for temperature management. The WTMP supports forecasts, historical analyses, and long-term planning efforts and advances previous modeling approaches by using an integrated modeling platform. This platform includes a data management system that acquires …
A Time For... Reckoning With Kirk's Assassination, Donald Roth
A Time For... Reckoning With Kirk's Assassination, Donald Roth
Faculty Work Comprehensive List
"For Christians, engagement with culture is about a long-slow obedience in the same direction. It’s a deep investment in the communities where the Lord has placed us."
Posting about responding to cultural crises from In All Things, an online hub that offers insight into maintaining and faithful and orthodox Reformed Christian worldview while fearlessly engaging in every aspect of contemporary life – until all is made new.
A Time For... Reckoning with Kirk's Assassination
Somatostatin Receptor 2 Overexpression In Hepatocellular Carcinoma: Implications For Cancer Biology And Therapeutic Applications, Servando Hernandez Vargas, Solmaz Aghaamiri, Jack T Adams, Tyler M Bateman, Belkacem Acidi, Sukhen C Ghosh, Vahid Khalaj, Ahmed O Kaseb, Hop S Tran Cao, Majid Momeny, Ali Azhdarinia
Somatostatin Receptor 2 Overexpression In Hepatocellular Carcinoma: Implications For Cancer Biology And Therapeutic Applications, Servando Hernandez Vargas, Solmaz Aghaamiri, Jack T Adams, Tyler M Bateman, Belkacem Acidi, Sukhen C Ghosh, Vahid Khalaj, Ahmed O Kaseb, Hop S Tran Cao, Majid Momeny, Ali Azhdarinia
The Brown Foundation: Institute of Molecular Medicine
Background: Somatostatin receptor 2 (SSTR2), a G protein-coupled receptor, is overexpressed in multiple malignancies, including hepatocellular carcinoma (HCC). While SSTR2 has traditionally been viewed as an inhibitory receptor involved in suppressing hormone secretion and cell proliferation, emerging evidence suggests a more complex role in cancer biology. However, the functional implications of SSTR2 expression in HCC remain poorly understood. This study aimed to systematically investigate the molecular landscape associated with SSTR2 expression in HCC and evaluate its potential as a therapeutic target.
Methods: SSTR2 expression patterns across 22 tumor types were assessed using TNMplot, and its expression in HCC was further …
Preclinical Perspectives On Disorders Of The Temporomandibular Joint: Tracing The Past, Navigating The Present, And Shaping The Future, John K Neubert, Kyle Allen, Tamara Alliston, Alejandro J Almarza, Kyriacos A Athanasiou, Basak Donertas-Ayaz, Bruna Balbino De Paula, Roxanne Bavarian, Nidhi Bhutani, Brian E Cairns, Robert M Caudle, Yang Chai, Jian-Fu Chen, Yong Chen, Glenn T Clark, Yenisel Cruz-Almeida, Alexandre F Dasilva, Paul L Durham, Airam Vivanco Estela, Millie Embree, Roger Fillingim, Fernando Guastaldi, Shruti Handa, Sunil D Kapila, David Keith, Keith L Kirkwood, Phillip Kramer, Katherine T Martucci, Niall P Murphy, Andrea G Nackley, Richard Ohrbach, Benedikt Sagl, Shad B Smith, Feng Tao, Beth Winkelstein, Hai Yao, Simon Young, Michael S Gold
Preclinical Perspectives On Disorders Of The Temporomandibular Joint: Tracing The Past, Navigating The Present, And Shaping The Future, John K Neubert, Kyle Allen, Tamara Alliston, Alejandro J Almarza, Kyriacos A Athanasiou, Basak Donertas-Ayaz, Bruna Balbino De Paula, Roxanne Bavarian, Nidhi Bhutani, Brian E Cairns, Robert M Caudle, Yang Chai, Jian-Fu Chen, Yong Chen, Glenn T Clark, Yenisel Cruz-Almeida, Alexandre F Dasilva, Paul L Durham, Airam Vivanco Estela, Millie Embree, Roger Fillingim, Fernando Guastaldi, Shruti Handa, Sunil D Kapila, David Keith, Keith L Kirkwood, Phillip Kramer, Katherine T Martucci, Niall P Murphy, Andrea G Nackley, Richard Ohrbach, Benedikt Sagl, Shad B Smith, Feng Tao, Beth Winkelstein, Hai Yao, Simon Young, Michael S Gold
Faculty, Staff and Student Publications
Temporomandibular disorders (TMDs) are complex conditions characterized by orofacial pain and dysfunction, affecting a significant portion of the population. TMDs may involve joint and/or muscle pain, dysfunction (e.g., noise, limited or altered jaw movements), or both, leading to a marked decrease in quality of life. Patients often experience functional limitations that hinder eating, speaking, and daily activities. Additionally, TMDs are frequently associated with psychological distress, including anxiety and depression, which further impacts overall well-being. Despite the profound individual and societal impact of TMDs, effective therapies remain elusive, partly due to deficiencies in translational research. A primary limitation in the TMD …
Potential For Therapeutic Alteration Of The Underlying Biology Of Epilepsy, Michael R. Sperling, Jurriaan M. Peters, Qian Wu, Michelle Guignet, H. Steve White, Evelyn K. Shih, Leock Y. Ngo, Enrique Carrazana, Adrian L. Rabinowicz
Potential For Therapeutic Alteration Of The Underlying Biology Of Epilepsy, Michael R. Sperling, Jurriaan M. Peters, Qian Wu, Michelle Guignet, H. Steve White, Evelyn K. Shih, Leock Y. Ngo, Enrique Carrazana, Adrian L. Rabinowicz
Department of Neurology Faculty Papers
Approximately 30-35% of people with epilepsy experience seizures despite taking antiseizure medications. Recurrent seizures that are independent of status epilepticus can be associated with neuronal injury and structural changes to the brain, as well as diminished cognitive function, mood, and quality of life. A treatment that alters the underlying biology of epilepsy, thereby reducing the seizure burden and its attendant consequences, would be of great value in preventing these detrimental effects. In this review, we summarize preclinical and clinical research on pharmacological treatments that may favorably alter the underlying biology of epilepsy (i.e., disease modification or antiepileptogenesis). A reduction in …
Age-Dependent Changes In Reproductive Behaviour And Success In A Long-Lived Beetle (Bolitotherus Cornutus), C. A. Greene, L. D. Mitchem, Vitor Dos Anjos , '21, E. D. Brodie Iii, Vincent A. Formica
Age-Dependent Changes In Reproductive Behaviour And Success In A Long-Lived Beetle (Bolitotherus Cornutus), C. A. Greene, L. D. Mitchem, Vitor Dos Anjos , '21, E. D. Brodie Iii, Vincent A. Formica
Biology Faculty Works
Age-related changes in behaviors often result in shifts in an individual’s competitive ability, reproductive success, and fitness. However, how mating behaviors, aggression, and mating success simultaneously change as individuals age in natural populations remains understudied. Investigating these age-dependent effects in wild populations could reveal how age-specific patterns shape social dynamics and influence natural selection. In this study, we ask how behaviors associated with mating and reproductive success vary across age in a wild metapopulation of a long-lived beetle, Bolitotherus cornutus. We used both cross-sectional and longitudinal data from a multi-year field study of individually marked beetles to investigate how …
Impact Of Gut Microbiota On Drug Metabolism And Absorption, Kieran Burke, Yanyan Li
Impact Of Gut Microbiota On Drug Metabolism And Absorption, Kieran Burke, Yanyan Li
Pharmacy Faculty Scholarship
Purpose of Review: Complex interactions between gut microbiota and various drugs can significantly influence drug phar-macokinetics. We examined recent in vitro, ex vivo, and in vivo studies to understand how microbiota directly influences drug metabolism and absorption in order to inform future research and clinical practice. Recent Findings: Considerable progress has been made for multiple drug classes using in vitro anaerobic culturing assays and ex vivo systems with human fecal communities, as well as animal models that have provided insights into both direct microbial metabolism of drugs and indirect host-microbiota interactions via regulation of host enzymes or transporters. However, how …
"Elements Don’T Mix!": Unearthing Racial Scripts And A Rhetorical Economy Of Whiteness In Disney And Pixar's Elemental, Linsay M. Cramer, Gabriel A. Cruz
"Elements Don’T Mix!": Unearthing Racial Scripts And A Rhetorical Economy Of Whiteness In Disney And Pixar's Elemental, Linsay M. Cramer, Gabriel A. Cruz
Communication, Media, and Culture
Using a narrative rhetorical approach, we map how Disney and Pixar’s 2023 film, Elemental, sustains a rhetorical economy of whiteness, as theorized by Asen and Kelly, which emphasizes the degree to which rhetorical constructions of racial difference are foundational to whiteness and economic systems. We identify and critique how Elemental discursively contributes to a system of exclusivity for those within the bounds of whiteness concerning economic mobility via racial scripts. Created and produced during Joe Biden’s United States (U.S.) presidential term (2021–2025), Elemental offers a metaphorical tale that engages the fractious, politically conservative anxieties concerning diversity, equity, and inclusion (DEI) …
2025-09-12 Minutes & Appendices, Longwood University
2025-09-12 Minutes & Appendices, Longwood University
Board of Visitors Meeting Minutes 1964-
No abstract provided.
Reining In Plasticulture From Land To Sea: Pacific Northwest (Usa) Perspectives On Agriculture And Aquaculture, Susanne M. Brander, Gail A. Langellotto, Minal T. Mistry, Sebastian L. Singleton, Mackenna A. Hainey, Lauren M. Kashiwabara, Kelsey Arthur, Elise F. Granek, Kervelle Baird, Ricardo Palazuelos, Multiple Additional Authors
Reining In Plasticulture From Land To Sea: Pacific Northwest (Usa) Perspectives On Agriculture And Aquaculture, Susanne M. Brander, Gail A. Langellotto, Minal T. Mistry, Sebastian L. Singleton, Mackenna A. Hainey, Lauren M. Kashiwabara, Kelsey Arthur, Elise F. Granek, Kervelle Baird, Ricardo Palazuelos, Multiple Additional Authors
Environmental Science and Management Faculty Publications and Presentations
Plastic use in food production—known as plasticulture—has transformed agriculture and aquaculture globally. Plasticulture gained momentum in the mid-20th century with the development of novel plastic materials, and by 2009, U.S. farmers used over 200 million pounds of plastic films annually. Though plastics have increased yields and efficiency, they now pose environmental hazards through the release of microplastics (MPs) and chemicals. Despite extensive documentation of MPs in the environment, their role in U.S. food production and impacts on crop, livestock, and aquaculture health remain underexplored. In regions like the Pacific Northwest (PNW), with robust agricultural and aquaculture sectors, plastics from films, …
Non-Neutralizing Antibodies To Influenza A Matrix-Protein-2-Ectodomain Are Broadly Effective Therapeutics And Resistant To Viral Escape Mutations., Teha Kim, Lynn Bimler, Sydney L Ronzulli, Amber Y Song, Scott K Johnson, Cheryl A Jones, S Mark Tompkins, Silke Paust
Non-Neutralizing Antibodies To Influenza A Matrix-Protein-2-Ectodomain Are Broadly Effective Therapeutics And Resistant To Viral Escape Mutations., Teha Kim, Lynn Bimler, Sydney L Ronzulli, Amber Y Song, Scott K Johnson, Cheryl A Jones, S Mark Tompkins, Silke Paust
Faculty Research 2025
Influenza A viruses remain a global health threat, yet no universal antibody therapy exists. Clinical programs have centered on neutralizing mAbs, only to be thwarted by strain specificity and rapid viral escape. We instead engineered three non-neutralizing IgG2a mAbs that target distinct, overlapping epitopes within the conserved N terminus of the M2 ectodomain (M2e). Combined at low dose, this "triple M2e-mAb" confers robust prophylactic and therapeutic protection in mice challenged with diverse human and zoonotic IAV strains, including highly pathogenic variants. Therapeutic efficacy depends on Fc-mediated effector activity via FcγRI, FcγRIII, and FcγRIV, rather than in vitro neutralization. Serial passaging …
2025 September 12 - Audit Committee Agenda And Minutes, Board Of Trustees, East Tennessee State University
2025 September 12 - Audit Committee Agenda And Minutes, Board Of Trustees, East Tennessee State University
Board of Trustees Agendas and Minutes
No abstract provided.
Systematics And Phylogeography Of Mundochthonius Chamberlin, 1929, In The Pacific Northwest (Chelicerata, Pseudoscorpiones), Amanda Rai Montoya-Cowan
Systematics And Phylogeography Of Mundochthonius Chamberlin, 1929, In The Pacific Northwest (Chelicerata, Pseudoscorpiones), Amanda Rai Montoya-Cowan
Dissertations and Theses
Understanding the processes that drive genetic divergence and species formation is central to evolutionary biology. Invertebrates with low dispersal ability, such as pseudoscorpions, are especially prone to cryptic diversification due to their occupancy of niche microhabitats and sensitivity to landscape barriers. Despite their ecological roles as predators and bioindicators, pseudoscorpions remain one of the least studied arachnid groups, with limited taxonomic resolution and few integrative studies. This research focuses on the genus Mundochthonius in the Pacific Northwest, particularly M. pacificus, a morphologically conserved species whose true diversity and distribution remain poorly understood.
Field surveys guided by a GIS-based habitat …
Identification And Characterization Of A Metal Binding-Independent Rift Valley Fever Virus Endonuclease Inhibitor, Cara D Kirby, Gai Liu, Farheen Fatma, Maris R Pedlow, Narendran G-Dayanandan, Nitin Sharma, Zachary D Frey, Rachael E Rush, Steven C Cardinale, Andrzej M Krezel, Amy L Hartman, Terry L Bowlin, Daisy W Leung, Gaya K Amarasinghe
Identification And Characterization Of A Metal Binding-Independent Rift Valley Fever Virus Endonuclease Inhibitor, Cara D Kirby, Gai Liu, Farheen Fatma, Maris R Pedlow, Narendran G-Dayanandan, Nitin Sharma, Zachary D Frey, Rachael E Rush, Steven C Cardinale, Andrzej M Krezel, Amy L Hartman, Terry L Bowlin, Daisy W Leung, Gaya K Amarasinghe
2020-Current year OA Pubs
The viral cap-snatching mechanism, facilitated by the endonuclease (EndoN) domain of viral polymerases, is critical for viral gene transcription and translation and is therefore an attractive target for antiviral development. The successful development of EndoN inhibitor XOFLUZA (Baloxavir marboxil) has opened the possibility that the EndoN domain of negative-sense RNA viruses (NSVs) can be targeted in a similar fashion. Rift Valley Fever Virus (RVFV) belongs to the
Effects Of 17Β-Estradiol Treatment On Metabolic Function And Aortic Relaxation In Castrated Male Rats, Rifat A. Islam, Md R. Razan, Ankita Poojari, Mohammad M. Rahman, Hao Wei, Hana S. Alhamadsheh, Melanie Felmlee, Atefeh Rabiee, Mitra Esfandiarei, Roshanak Rahimian
Effects Of 17Β-Estradiol Treatment On Metabolic Function And Aortic Relaxation In Castrated Male Rats, Rifat A. Islam, Md R. Razan, Ankita Poojari, Mohammad M. Rahman, Hao Wei, Hana S. Alhamadsheh, Melanie Felmlee, Atefeh Rabiee, Mitra Esfandiarei, Roshanak Rahimian
Pacific Faculty Work
Exogenous estrogen use in male-to-female individuals has been linked to increased cardiovascular disease risk, though the mechanisms remain unclear. This study examines the effects of 17β-estradiol (E2) on metabolic and aortic function in castrated (CAS) male Sprague Dawley rats. CAS rats received subcutaneous E2 (CAS + E2) or placebo (CAS + PL) pellets for ~35 days, with intact males serving as controls. Endothelium-dependent vasorelaxation (EDV) in response to acetylcholine and contractile responses to phenylephrine were measured in aorta before and after pharmacological inhibitors. Metabolic parameters and expression of proteins associated with vascular and insulin signaling were also determined in aorta …
A Novel Sialylation Pathway Mediated By Extracellular Vesicles In Aggressive Prostate Cancer, Camila A. Bach, Md Niamat Hossain, Ishan J. Chaudhari, Cecilia E. Verrillo, Nicole M. Naranjo, Isabella Amoroso, Anna Testa, Samuel Sey, W. Kevin Kelly, Susan L. Bellis, Aurelio Lorico, Ada G. Blidner, Gabriel A. Rabinovich, Lucia R. Languino
A Novel Sialylation Pathway Mediated By Extracellular Vesicles In Aggressive Prostate Cancer, Camila A. Bach, Md Niamat Hossain, Ishan J. Chaudhari, Cecilia E. Verrillo, Nicole M. Naranjo, Isabella Amoroso, Anna Testa, Samuel Sey, W. Kevin Kelly, Susan L. Bellis, Aurelio Lorico, Ada G. Blidner, Gabriel A. Rabinovich, Lucia R. Languino
Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers
Altered cell surface glycosylation is a hallmark of cancer; among aberrant glycan structures, hypersialylated proteins contribute to disease progression. The enzyme ST6 β-galactoside α2,6-sialyltransferase 1 (ST6GAL1) mediates α2,6-linked sialylation of N-glycosylated proteins and is upregulated in many cancers, including prostate cancer (PrCa). We propose that ST6GAL1 may be released by cancer cells in small extracellular vesicles (sEVs) in the PrCa tumor microenvironment to potentially modulate cell surface sialylation in recipient cells. We isolated sEVs from PrCa cells by density gradient separation and characterized them by nanoparticle tracking analysis using ZetaView and immunoblotting analysis. We identified ST6GAL1 in both its membrane-bound …
Conference Presentation: 'Ai Disruptions In Higher Education', Cristo Leon Ph.D., James Lipuma Ph.D., Maximus Rafla
Conference Presentation: 'Ai Disruptions In Higher Education', Cristo Leon Ph.D., James Lipuma Ph.D., Maximus Rafla
STEM for Success Resources
Power Point presentation
A Picture Paints A Thousand Words: Understanding How People Conceptualise Autism Through Images, Gray Atherton, Emily Dawson, Andrea Piovesan, Lauren Hawksworth-Quill, Liam Cross
A Picture Paints A Thousand Words: Understanding How People Conceptualise Autism Through Images, Gray Atherton, Emily Dawson, Andrea Piovesan, Lauren Hawksworth-Quill, Liam Cross
School of Psychology
Conceptions of autism and neurodiversity vary widely, with differing views on how they are portrayed in contemporary culture. Although autism scholars have long advocated for greater involvement of autistic individuals in knowledge creation, meaningful co-production between autistic stakeholders, researchers, and the broader community remains limited. To explore differences in autism knowledge between autistic and non-autistic people, we used a qualitative method called visual elicitation. We invited the public to upload an image they felt represented autism and explain their choice. Through thematic analysis of these images and their accompanying descriptions, we identified three key themes highlighting how autism is currently …
Structural Analysis Of Pseudomonas Phage Dev Virion-Associated Rna Polymerase (Gp71), James Scherer
Structural Analysis Of Pseudomonas Phage Dev Virion-Associated Rna Polymerase (Gp71), James Scherer
All ETDs from UAB
DEV is a Pseudomonas aeruginosa bacteriophage part of a newly reclassified genus called Schitoviridae. This group of bacteriophages is also referred to as “N4-like” phages, after the prototypical Escherichia coli phage N4, originally isolated from sewage water in 19661. N4, and other phages in the group, contain a large, virion-associated RNA polymerase (vRNAP). This vRNAP is vital to the proliferation of the phage, as it performs the transcription of the early gene products and potentially acts as a motor that helps eject the viral genome into the host bacteria. In DEV, the vRNAP is also known as gene product 71 …
Investigating How Evolution Has Affected The Neuroanatomy Of Adult Astyanax Mexicanus, Peter Igwilo
Investigating How Evolution Has Affected The Neuroanatomy Of Adult Astyanax Mexicanus, Peter Igwilo
Electronic Theses and Dissertations
The topology of the brain is highly conserved across phyla, yet the evolutionary processes driving anatomical divergence remain poorly understood. The fish Astyanax mexicanus, which exists in both surface- and cave-dwelling morphs within the same species, provides a powerful model for studying brain evolution. While previous studies have focused on larvae, imaging adult brains has been challenging due to their size and opacity. This study overcame these limitations using tissue clearing, light sheet imaging, and computational analysis to generate a comprehensive adult brain atlas. Using nuclear staining and antibody labeling, brain-wide 3D maps were created to compare regional size, shape, …
Infusion Of Blood From Young And Old Mice Modulates Amyloid Pathology, Matias Pizarro, Ruben Gomez-Gutierrez, Ariel Caviedes, Catalina Valdes, Ute Woehlbier, Cristian Vargas, Mauricio Hernandez, Claudia Duran-Aniotz, Rodrigo Morales
Infusion Of Blood From Young And Old Mice Modulates Amyloid Pathology, Matias Pizarro, Ruben Gomez-Gutierrez, Ariel Caviedes, Catalina Valdes, Ute Woehlbier, Cristian Vargas, Mauricio Hernandez, Claudia Duran-Aniotz, Rodrigo Morales
Faculty, Staff and Student Publications
Alzheimer's disease (AD) is a neurodegenerative disease characterized by the accumulation of misfolded proteins in the brain. Recently, the impact of blood components in the progression of this disease has come to attention. This study investigates the effects of infusing blood from young and old wild-type mice into transgenic mice that model AD brain amyloidosis. Impaired memory and Aβ accumulation were observed in mice infused with blood from old donors. A proteomic analysis in the brain of these mice identified alterations in components related to synaptogenesis and the endocannabinoid system. The α2δ2 protein, associated with neuronal calcium regulation, was validated …
Loss Of Ptdss1 In Tumor Cells Improves Immunogenicity And Response To Anti-Pd-1 Therapy, Jielin Liu, Shelley Herbrich, Sreyashi Basu, Yulong Chen, Ashwat Nagarajan, Swetha Anandhan, Sangeeta Goswami, Liangwen Xiong, Baoxiang Guan, Padmanee Sharma
Loss Of Ptdss1 In Tumor Cells Improves Immunogenicity And Response To Anti-Pd-1 Therapy, Jielin Liu, Shelley Herbrich, Sreyashi Basu, Yulong Chen, Ashwat Nagarajan, Swetha Anandhan, Sangeeta Goswami, Liangwen Xiong, Baoxiang Guan, Padmanee Sharma
Faculty, Staff and Student Publications
PTDSS1 (phosphatidylserine synthase 1) encodes an enzyme that facilitates production of phosphatidylserine (PS), which mediates a global immunosuppressive signal. Here, based on in vivo CRISPR screen, we identified PTDSS1 as a target to improve anti-PD-1 therapy. Depletion of Ptdss1 in tumor cells increased expression of interferon-γ (IFN-γ)-regulated genes, including B2m, Cxcl9, Cxcl10, and Stat1, even in the absence of IFN-γ stimulation in vitro. Loss of Ptdss1 in tumor cells also led to increased expression of MHC-I, enhanced cytotoxicity of CD8+ T cells, and increased frequency of an iNOS+ myeloid subset. A gene signature derived from the …
The Diamond, September 12, 2025, Dordt University
The Diamond, September 12, 2025, Dordt University
Dordt Diamond
- Front Page: Staffing and Service Challenges in the New Atrium; Summer Storm Recap: Historic 'Derecho' Wind Hits Sioux Center; In God's Hands, On Our Helmets: Honoring Liam Sorensen's Life
- News: The Cottages: A Place to Call Home; Sioux Center Welcomes New Pickleball Courts
- Feature: Construction Updates and Ripples Seen on Campus; Dr. Justin Bailey and the 2025-2026 Chapel Vision; Dordt Welcomes Kristin Brouwer as New Director of Campus Ministries
- Politics: 'Pursuing Peace': Trump's Meeting with Putin; Funding Cuts Hinder the "Second Space Race"
- Opinion: Jersey on the Wall: Recent Reflection on Grief; Kraft Korner: …
Observations On Predation Of The Flatback Turtle Natator Depressus By The Saltwater Crocodile Crocodylus Porosus At A Major Rookery In Northern Australia, Casper Avenant, James Gee
Observations On Predation Of The Flatback Turtle Natator Depressus By The Saltwater Crocodile Crocodylus Porosus At A Major Rookery In Northern Australia, Casper Avenant, James Gee
Research outputs 2022 to 2026
Context: We examined predation by the saltwater crocodile (Crocodylus porosus) on the flatback turtle (Natator depressus), an Australian endemic, at Cape Domett, a significant nesting site in Cambridge Gulf, northern Australia, where crocodile populations have recovered since legislative protection was implemented in the 1970s. Aims: The investigation aimed to document crocodile predation on flatback turtles across hatchling and adult life stages, assess predation strategies, and evaluate ecological impacts on this genetically distinct turtle stock. Methods: Conducted over three Austral winters (2021–2023), the study utilised infrared videography, unmanned aerial vehicles, and beach patrols to observe predation events in a population of …
Distinct Transcriptional Regulation Of The Wnt And Tgfβ Signaling Families Associated With Wound Healing And Fibrotic Outcomes To Lens Injury, Catherine Lalman, Kylie R. Stabler, Joshua Disatham, Lisa A. Brennan, Marc Kantorow, Janice L. Walker
Distinct Transcriptional Regulation Of The Wnt And Tgfβ Signaling Families Associated With Wound Healing And Fibrotic Outcomes To Lens Injury, Catherine Lalman, Kylie R. Stabler, Joshua Disatham, Lisa A. Brennan, Marc Kantorow, Janice L. Walker
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
Posterior capsule opacification (PCO) is a fibrotic complication of cataract surgery caused by aberrant repair of residual lens cells. It remains unclear how the lens injury response shifts toward a pathological repair process. Here, we performed a transcriptional analysis of two major pro-fibrotic pathways, the TGF-β superfamily and Wnt signaling pathways to determine how they are differentially regulated during regenerative wound healing versus fibrosis in a lens injury model. For these studies, RNA sequencing was performed on an ex vivo lens explant system that models post-surgical healing within regenerative and fibrotic microenvironments, from 0 to 3 days post-injury. Fibrotic conditions …
Targeting Kinin B1r Attenuates Hypertension Through At1r-Dependent Mechanisms, Drew Theobald, Riley N. Bessetti, Yumei Feng Earley, Eric Lazartigues, Karen Litwa, Srinivas Sriramula
Targeting Kinin B1r Attenuates Hypertension Through At1r-Dependent Mechanisms, Drew Theobald, Riley N. Bessetti, Yumei Feng Earley, Eric Lazartigues, Karen Litwa, Srinivas Sriramula
School of Medicine Faculty Publications
BACKGROUND: Neurogenic hypertension is chronically high blood pressure that is initiated and maintained through excessive sympathetic nervous system activity and has been associated with increased B1R (kinin B1 receptor) activation. We previously reported a central role for B1R in mediating inflammatory pathways in the development of deoxycorticosterone acetate salt hypertension. Additionally, we identified a causal relationship between B1R expression after Ang II (angiotensin II) stimulation, and that B1R can mediate the bidirectional interaction between neuroinflammation and oxidative stress. However, whether there are any interactions between AT1R (Ang II-type I receptor) and B1R, and if B1R can mediate the effects of …
In Vivo Efficacy Of A Broad-Spectrum Antiviral Combination Against Yellow Fever In A Hamster Model, Abbie E. Weight, Hunter Stanger, Robert J. Geraghty, Laurent F. Bonnac, Justin G. Julander
In Vivo Efficacy Of A Broad-Spectrum Antiviral Combination Against Yellow Fever In A Hamster Model, Abbie E. Weight, Hunter Stanger, Robert J. Geraghty, Laurent F. Bonnac, Justin G. Julander
Animal, Dairy, and Veterinary Science Student Research
Yellow fever virus (YFV) recurrently causes severe outbreaks in tropical regions of South America and Africa and an average of 30 to 40 thousand deaths worldwide each year. An effective vaccine is available but the coverage of the population in countries at risk is not optimal. No antivirals are currently approved for YFV treatment. Herein, we describe the evaluation of 6-MMPr, a de-novo-purine-nucleotide biosynthesis inhibitor, as a potentiator for enhanced activity of the broad-spectrum antiviral drug favipiravir in a hamster model of yellow fever. Administration of 6-MMPr was well-tolerated and a combination of favipiravir and 6-MMPr did not cause …
The Hidden Link Between Hiv And Cardiomyopathy: Unraveling Hiv's Impact On The Heart, Toluwalase Awoyemi, Oluwaremilekun Zeth Tolu-Akinnawo, Andrew Greek, Oluwakemi Adenuga, Chukwuebuka Asogwa, Isaac Ekundayo, Olamide Odusola, Oyinlola Fasehun, Mercy Ajayi, Onyinye Ugoala, Luther-King Fasehun, Adeleke Oluwaseun Dorcas, Michael Angarone
The Hidden Link Between Hiv And Cardiomyopathy: Unraveling Hiv's Impact On The Heart, Toluwalase Awoyemi, Oluwaremilekun Zeth Tolu-Akinnawo, Andrew Greek, Oluwakemi Adenuga, Chukwuebuka Asogwa, Isaac Ekundayo, Olamide Odusola, Oyinlola Fasehun, Mercy Ajayi, Onyinye Ugoala, Luther-King Fasehun, Adeleke Oluwaseun Dorcas, Michael Angarone
Student Publications
This comprehensive review examines the complex relationship between human immunodeficiency virus (HIV) and cardiomyopathy, focusing on the underlying molecular mechanisms, clinical manifestations, diagnostic approaches, and treatment strategies. It highlights the significant global health burden posed by HIV and its potential to cause long-term cardiovascular complications. The review investigates the pathogenesis of HIV-associated cardiomyopathy. It elucidates the intricate cellular and molecular pathways involved, including the actions of neutrophils, monocytes, macrophages, and lymphocytes in cardiac inflammation. Key signaling pathways such as TNF-NF-κB and the caspase-1 inflammasome are detailed, as they contribute to cardiac infection and injury. The clinical manifestations of HIV-associated cardiomyopathy …
Opposing Synovial Cannabinoid Receptor Type 2 And Transient Receptor Potential Vanilloid 1 Expression In Painful Osteoarthritis, Collin A. Toups, Lauren G. Guillot, Kaitlyn Redondo, Sydney Jensen, Jennifer Klein, Luis Marrero
Opposing Synovial Cannabinoid Receptor Type 2 And Transient Receptor Potential Vanilloid 1 Expression In Painful Osteoarthritis, Collin A. Toups, Lauren G. Guillot, Kaitlyn Redondo, Sydney Jensen, Jennifer Klein, Luis Marrero
School of Medicine Faculty Publications
Knee osteoarthritis (kOA) poses a major health challenge worldwide, but current non-surgical treatments have limited long-term success and do not address the underlying disease process. This study explores the complex relationship between the endocannabinoid system (ECS) and the endovanilloid system (EVS) in the synovial membrane of patients with kOA undergoing total knee replacement, focusing on how these systems relate to patient-reported pain and histological synovitis. Synovial tissues and fluid from patients grouped into high and low pain categories based on the Knee Injury and Osteoarthritis Outcome Score (KOOS) were examined for cannabinoid receptor type 2 (CB2R), transient receptor potential vanilloid …
“A Field Beaten Bare Of Grass”: Samuel Youd’S The Death Of Grass (1956) And The Scouring Of The Shire, Kristine Larsen
“A Field Beaten Bare Of Grass”: Samuel Youd’S The Death Of Grass (1956) And The Scouring Of The Shire, Kristine Larsen
Journal of Tolkien Research
One of the novels Tolkien admits to liking (according to his published letters) was Samuel Youd’s thriller The Death of Grass (1956), published under the pen name John Christopher. Among the novel’s aspects that might have particularly resonated with Tolkien included environmental concerns, analogs with Tolkien’s World War II experience (especially rationing), and an emphasis on fairy-story Consolation and Recovery, among others. But in addition, parallels with “The Scouring of the Shire” and other late episodes in The Lord of the Rings clearly deserve further analysis. This paper therefore engages with Youd’s novel through that specific lens.