Digital Commons Network^™

Biochemical And Clinical Response To A Sulfur-Restricted Diet In Ethylmalonic Encephalopathy, Steven H Lang, Andres Caceres Salgado, Matthew T Snyder, Brandy Rawls-Castillo, Aaron Williams, Charul Gijavanekar, Sarah H Elsea, Xia Wang, Mary Elizabeth M Tessier, Claudia Soler-Alfonso, Fernando Scaglia

Faculty, Staff and Students Publications

Introduction: Ethylmalonic encephalopathy (EE) is an often-severe inborn error of metabolism caused by biallelic variants in the ETHE1 gene leading to impaired detoxification of hydrogen sulfide (H2S). H2S is produced both exogenously by anerobic intestinal bacteria as well as by the endogenous catabolism of the sulfur-containing amino acids methionine and cysteine. Existing therapies including metronidazole, N-acetylcysteine (NAC), and orthotopic liver transplantation (OLT) have been pursued with the objective of reducing or detoxifying exogenously produced H2S. However, strategies to reduce endogenously produced H2S using a methionine and cysteine restricted diet are an understudied therapeutic avenue.

Methods: We performed an open-label, …

Transoral Robotic-Assisted Removal Of A Submucosal Pyriform Sinus Foreign Body, Elisabeth Wenneker, Rebecca Doctor, Ari Schuman, Adam Szymanowski, Ray Wang

Faculty, Staff and Students Publications

Background: Submucosal foreign bodies of the medial pyriform sinus represent a challenge given limited visualization and difficult retraction with endoscopic approaches, and risk of injury to the recurrent laryngeal nerve with open approaches. Transoral robotic surgery (TORS) offers improved visualization and multiple working arms to facilitate retraction. We present a novel case utilizing the Da Vinci SP system for removal of an embedded fishbone of the medial pyriform sinus.

Results: An 84-year-old woman presented with five days of odynophagia and globus sensation after swallowing a fish bone. Non-contrast computed tomography scan revealed a 3.0 cm submucosal object within the post-cricoid …

Plasma Metabolomic And Proteomic Signatures Of Blood Pressure Management After Bariatric Surgery Among Adolescents, Shudi Pan, Zhenjiang Li, Juan Pablo Lewinger, Jesse A Goodrich, Hongxu Wang, Sarah Rock, Carmen Chen, Todd M Jenkins, Stephanie Sisley, Stephen R Daniels, Douglas I Walker, Max T Aung, Erika Garcia, Rob Mcconnell, Sandrah P Eckel, Michele A La Merrill, Tanya L Alderete, Zhuanghua Chen, Frank D Gilliland, Thomas H Inge, David V Conti, Justin R Ryder, Lida Chatzi

Faculty, Staff and Students Publications

Background: Emerging omics approaches, including metabolomics and proteomics, can be integrated into obesity treatment for better blood pressure management. We tested whether preoperative metabolomic and proteomic profiles predict long-term elevated blood pressure (EBP) changes better than known risk factors in adolescents undergoing bariatric surgery.

Methods: We included 108 participants from the Teen-LABS (Teen-Longitudinal Assessment of Bariatric Surgery). Plasma untargeted metabolomics (via liquid chromatography with high-resolution mass spectrometry) and Olink proteomics were assessed pre surgery. An elastic net model with stability selection was used to identify features predictive of EBP reductions 5 years post surgery. Models including identified metabolites, proteins, and …

From Bladder To Brain: How You Know When It’S Time To Go, Anne M J Verstegen, Kara L Marshall

Duncan NRI Faculty and Staff Publications

The decision to urinate relies on assessing bladder fullness and context to determine an appropriate time and place to go. Any disruption in this interoceptive process results in frequent and sometimes debilitating consequences in daily life. Recent work has uncovered key pathways and brain regions that contribute to the sense of bladder stretch and the control of urinary reflexes, but many open questions remain. Here, we review the known mechanisms that convey sensory information from the bladder to the brain and back down again, and we highlight the knowledge gaps and opportunities for better understanding this system, which will be …

Effect Of The Debrief Component Of The Experiential Learning Model On Attitudes Of 4-H Camp Participants, Creenna Bocksnick

Graduate Theses and Dissertations

This study examined the effect of the debrief/reflection component of the Experiential Learning Model on attitudes of 5 - 12-year-olds (n = 58) and 13 - 15-year-old (n = 22) campers attending a three-day camp session during summer 2022. The 5- 12-year-old campers engaged in canoeing/paddleboarding, archery, rock climbing, leather crafting, and fishing. The 13 - 15-year-old campers engaged in canoeing/paddleboarding, rock climbing/giants ladder, high ropes course, and noodle boat races. Both groups of campers were randomly assigned in approximately equal numbers to either a no-debrief (control) or de-brief (treatment) group. For each camp activity the control group completed a …

Increasing Soil Health In Zero-Grade, Flood-Irrigated Rice In Eastern Arkansas, Hannah Elizabeth Vickmark

Graduate Theses and Dissertations

In an effort to build and maintain soil health and sequester soil C, many producers and researchers are turning towards regenerative management practices in agricultural systems, such as reduced tillage or no-tillage (NT), the implementation of winter cover crops (CC), and the use of organic or green manures, such as biochar. However, little research is being conducted on the long-term soil health and agronomic benefits of these practices in a flood-irrigated rice (Oryza sativa L.) production system. Three replications of seven treatment combinations were applied to 6.1 x 30.5 m rice plots. Baseline soil health properties were quantified at six …

Using Color And Fluorescent Spectrometry As A New Rapid Cleaning Verification Method In Poultry Processing Plants, Clark Griscom

Graduate Theses and Dissertations

The poultry industry is expected to be growing at 3% in the total global market with the U.S. being the largest producer of poultry meat. Poultry processing plants are expected to produce 140 birds per minute with the potential of up to 175 birds per minute to meet the market demand. With the growing market and need for faster production, maintaining food safety needs to be a priority to ensure the safety of consumers. Over 9.9 million foodborne illness cases are reported each year in the United States. A change in food safety is needed, and one area lacking is …

Work-Related Pathology At Tell El-Amarna: The Physical Cost Of Building A New Capital City In The New Kingdom, Egypt, Heidi Suzanne Davis

Graduate Theses and Dissertations

This dissertation examines patterns of work-related indicators of physical stress in a skeletal sample from the non-elite adult population of the South Tombs Cemetery (STC) of Amarna, Egypt. Assessing work-related pathology using an integrative model of physical stress, this study considers the interactions of demographic parameters of age, sex, and injury recurrence, along with archaeological and documentary data to provide a biocultural contextual approach to physical stress in this population. The STC sample is compared to other samples from Egyptian and Nubian sites as well as historical samples believed to be under high physical demands and stressful conditions. The STC …

Micro-Greens, Not Micro-Yellows: Evaluating Dehydration-Based Preservation Techniques For Reducing Foodborne Pathogens And Quality Preservation On Microgreens, Travis S. Sananikone

Graduate Theses and Dissertations

Microgreens are increasingly popular among consumers due to their high nutritional value. However, their limited shelf-life remains a significant challenge. To extend their usability, small-scale growers increasingly apply home preservation methods like warm air drying or freeze-drying. However, the effects of these methods on common foodborne pathogens are not well understood. Radish and alfalfa microgreens were inoculated with cocktails of Salmonella enterica, Escherichia coli O157:H7, and Listeria monocytogenes 4b (ca. 8.0 log CFU/g). Treatments included dehydration in a commercial dehydrator, freeze-drying (-20°C, 24 h), and convective drying in an oven (60°C for 4 h), and convective drying in an oven …

Consequences Of Secondary Traumatic Stress On Individuals Without Formal Psychological Training Working With Trauma-Exposed Children, Juan F. Valdez

Electronic Theses and Dissertations

Literature has suggested that secondary traumatic stress could cause various adverse effects for individuals working with trauma-exposed populations. However, direct care workers performing in shelters designed to serve unaccompanied immigrant children are faced with the task of caring for these minors who may have been exposed to trauma in their home countries, while traveling to the United States, or after arriving in the country. This qualitative case study was conducted to understand and describe the experiences of 15 current employees and five ex-employees who have worked with unaccompanied children for at least a year. These individuals participated in in-depth personal …

Environmental Beliefs Among Evangelical Leadership, Jeffrey Stark

Dissertations

There has been consensus among climate scientists for over a decade about the reality of human caused climate change. Even with this consensus, the public understanding of this issue remains divided based on factors generally unrelated to the science. Evangelical Protestants are one group which consistently polls as more skeptical of climate change. This is true not only when compared to the general population but also when compared to other religious demographics. Most large-scale surveys of evangelicals assume the demographic to be a monolith and do not attempt to break the demographic down further. In this mixed methods study, we …

Judicial Ethics, The Supreme Court, And The Rule Of Law, Charles G. Geyh

Articles by Maurer Faculty

This Essay begins with a short history of judicial ethics regulation in the United States, ending with the adoption of codes of conduct by every state and federal judicial system except the Supreme Court of the United States. It then turns to a series of ethics controversies encircling the Supreme Court and its justices, which culminated in the Supreme Court adopting a Code of Conduct in 2023. Tapping into the social science literature, it argues that for codes to improve the ethical climate of an institution they must encourage psychological ownership of and “buy-in” to a code by those subject …

From Molecules To Models: A Holistic Review Of Autism Spectrum Disorder Mechanisms And Research Tools, Sriya Gullapalli, Lois Baldado, Megan W. Szobody, Anesu K. Murambadoro, Kevin Garcia Valdez, Arjun Bellamkonda, Daniela Gonzalez, Usman Ghumman, Nikhilesh Anand, Kelsey A. Potter-Baker, Bharathi Gadad

School of Medicine Publications

Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by persistent deficits in social communication and interaction, as well as restricted, repetitive patterns of behavior, interests, or activities. These features are associated with atypical early brain development and connectivity. While ASD has been traditionally associated with molecular genetic alterations, recent research highlights the significant contribution of various environmental factors to the pathophysiology of the disorder. Pathogenic genetic variations in key regulatory genes remain central to ASD risk; however, environmental influences such as advanced maternal or paternal age, poor maternal health during pregnancy, gestational diabetes mellitus, alterations in the early-life …

Administration Plan For Use Of Hippotherapy In Occupational Therapy, Ryanna Blake

Occupational Therapy Doctoral Capstones

The intention of this capstone experience was to promote the use of hippotherapy as a treatment strategy in the occupational therapy profession from an administrative and educational standpoint. Hundreds of research studies have indicated the effectiveness of hippotherapy for a variety of ages and diagnoses. However, there are still barriers that prevent hippotherapy from being more accessible and well-known, both by practitioners, client families, and the community. The project was executed at a startup psychotherapy clinic preparing to offer equine-assisted services in Tulsa, Oklahoma. The mutually beneficial partnership led to the creation of a generalized administration plan for an occupational …

A Morphological Cell Atlas Of The Freshwater Sponge Ephydatia Muelleri With Key Insights From Targeted Single-Cell Transcriptomes, Sally P. Leys, Lauren Grombacher, Daniel Field, Glen R.D. Elliott, Vanessa R. Ho, Amanda S. Kahn, Pamela J. Reid, Ana Riesgo, Emilio Lanna, Yuriy Bobkov, Joseph F. Ryan, April L. Horton

Faculty Research, Scholarly, and Creative Activity

How animal cell types, tissues, and regional body plans arose is a fundamental question in EvoDevo. Many current efforts attempt to link genetic information to the morphology of cells, tissues and regionalization of animal body plans using single-cell sequencing of cell populations. However, a lack of in-depth understanding of the morphology of non-bilaterian animals remains a considerable block to understanding the transitions between bilaterian and non-bilaterian cells and tissues. Sponges (Porifera), one of the earliest diverging animal phyla, pose a particular challenge to this endeavour, because their body plans lack mouths, gut, conventional muscle and nervous systems. With a goal …

Safe-Sora: Safe Text-To-Video Generation Via Graphical Watermarking, Zihan Su, Xuerui Qiu, Hongbin Xu, Tangyu Jiang, Jun-Hao Zhuang, Chun Yuan, Ming Li, Shengfeng He, Fei Yu

Research Collection School Of Computing and Information Systems

The explosive growth of generative video models has amplified the demand for reliable copyright preservation of AI-generated content. Despite its popularity in image synthesis, invisible generative watermarking remains largely underexplored in video generation. To address this gap, we propose Safe-Sora, the first framework to embed graphical watermarks directly into the video generation process. Motivated by the observation that watermarking performance is closely tied to the visual similarity between the watermark and cover content, we introduce a hierarchical coarse-to-fine adaptive matching mechanism. Specifically, the watermark image is divided into patches, each assigned to the most visually similar video frame, and further …

Stableguard: Towards Unified Copyright Protection And Tamper Localization In Latent Diffusion Models, Haoxin Yang, Bangzhen Liu, Xuemiao Xu, Cheng Xu, Yuyang Yu, Zikai Huang, Yi Wang, Shengfeng He

Research Collection School Of Computing and Information Systems

The advancement of diffusion models has enhanced the realism of AI-generated content but also raised concerns about misuse, necessitating robust copyright protection and tampering localization. Although recent methods have made progress toward unified solutions, their reliance on post hoc processing introduces considerable application inconvenience and compromises forensic reliability. We propose StableGuard, a novel framework that seamlessly integrates a binary watermark into the diffusion generation process, ensuring copyright protection and tampering localization in Latent Diffusion Models through an end-to-end design. We develop a Multiplexing Watermark VAE (MPW-VAE) by equipping a pretrained Variational Autoencoder (VAE) with a lightweight latent residual-based adapter, enabling …

The Effect Of Shared Decisions On Intertemporal Choice, Rosemarie M. Davidson

Masters Theses

Substance use disorders are a significant public health concern, and improving treatment outcomes requires a better understanding of the behavioral processes that influence drug consumption. Delay discounting, or the tendency to overvalue immediate reinforcers, is reliably more severe among individuals with substance use disorders. Recent work suggests that shared decision-making may increase tolerance for delayed rewards; however, prior studies used procedures that confounded delay to token delivery with delay to token exchange, limiting conclusions. The present study evaluates delay discounting across individual and social decision-making contexts using a traditional delay discounting paradigm.

Ten undergraduate participants completed sessions involving choices between …

Overview Of Huntington's Disease And Emerging Treatment Strategies: A Narrative Review, Alexis J. Vega, Gabriel V. Hernandez, Pearse A. O'Malley, Connor J. Robin, Amanda N. Parra, Giustino Varrassi, Sahar Shekoohi, Alan D. Kaye

School of Medicine Faculty Publications

Huntington's disease (HD) is an autosomal dominant, progressive neurodegenerative disorder caused by a cytosine-adenine-guanine trinucleotide repeat expansion in the huntingtin (HTT) gene. The symptoms of HD include severe motor dysfunction, cognitive issues, and emotional dysregulation. These combined issues are not only debilitating but also lead to depression/anxiety, increased suicide rates, and caregiver burnout. Our narrative review summarizes several recent studies examining the efficacy and differences among emerging treatment strategies for HD. A systematic search of peer-reviewed literature was conducted, focusing on recent studies that describe molecular genetic manipulation of the HTT gene/huntingtin protein. The results of our narrative review reveal …

Love Will Get You Further: Allan Leslie Combs And The Legacy Of Radiance, Julia C. Gardner

Journal of Conscious Evolution

In this reflective tribute, I draw on a November 2025 remembrance gathering for Allan Leslie Combs to explore how his scholarship on consciousness lived through his presence, pedagogy, and relationships. The article weaves reflections from students, colleagues, friends, and family to show how Leslie treated consciousness as a living, radiant field and knowledge as participatory. Speakers describe a mentor who walked beside their work, welcoming spiritual, creative, and embodied ways of knowing, while trusting love, humor, and trickster-mischief as legitimate modes of inquiry.

I then turn to my own dissertation research on play consciousness (PlayCS) as a tangible extension of …

Physics-Guided Strategies For Enhancing Neural Networks Trained With Limited Data, Jose Guadalupe Perez Zamora

Open Access Theses & Dissertations

Deep neural networks excel at a wide range of processing tasks across various disciplines. However, the quantity and quality of data significantly impact network performance. In specialized domains, high-quality datasets are often difficult to gather, interpret, and curate for effective learning. Few-shot learning techniques, including transfer learning, data augmentation, and meta-learning, have emerged to address these constraints.

We propose three physics-guided strategies for enhancing neural networks trained with limited data: (1) combining existing models like LSTMs with Physics-Informed Neural Networks through two-branch architectures that merge their outputs, (2) deriving custom physics-informed data augmentation algorithms to expand limited datasets, and (3) …

De Novo Genome Assembly, Annotation, And Characterization Of Chemosensory Genes In The Camel Ked (Hippobosca Camelina), Fredrick Kebaso, Souleymane Diallo, Caleb Kibet, Suhaila Hashim, John Mark O. Makwatta, Merid Getahun, Dennis Getange, Jean Baka Domelevo Entfellner, Daniel Masiga

All Peer-Reviewed Publications

Background: Hippobosca camelina (camel ked) is an obligate hematophagous ectoparasite that infests camels. Hematophagy inflicts painful bites leading to myiasis, anemia and pathogen transmission such as Candidatus Anaplasma camelii. A genome assembly for this biting flies is currently unavailable, limiting understanding of its genetics, including the chemosensory system.

Results: The assembly size for Hippobosca camelina female is 135.6 Mb with 17.08% repeated regions, an N50 of 1.2 Mb, a total of 2,182 contigs, a GC content of 33.5% and compleasm (Busco) completeness of 95.38% with the diptera_odb10 lineage (S:95.83%, 3148, D:0.30%, 10, F:0.30%, 10, I:0.00%, 0, M:3.56%, 117, N:3285) …

Pretreatment Methods For Organic Waste Management As Feed For Black Soldier Fly, Mube K. Hervé, Gatchueng F. Lionel, Ndomou C.H. Serge, Dzepe Daniel, Shaphan Y. Chia, Kana Jean Raphael, Kenfack Augustave, Djouaka Rousseau, Sali A. Ndindeng

All Peer-Reviewed Publications

Amidst escalating global urbanization and population growth, revolutionizing food systems and redefining waste management strategies has become essential. This study contributes to protein resource diversification in animal feed and offers a sustainable solution for organic waste management using black soldier fly larvae (BSFL) in Bafia, Cameroon. A survey characterized waste production in restaurants and households to assess quantity and quality. Collected organic wastes underwent two pre-treatments: heating, (60°C) and fermentation (4 days), while another batch was used fresh as a feeding substrate for BSFL, in contrast to a broiler starter diet over a 17-day larval feeding experimental period. Various parameters …

Opportunities For Expansion Of Push-Pull Technology As An Agroecological And Sustainable Intensification Approach In Africa, Gudeta W. Sileshi, Shem Kuyah, Meredith C. Schuman, Frank Chidawanyika, Beatrice W. Muriithi, Charles A.O. Midega, Adewole Olagoke, Michael H. Otim, Paramu L. Mafongoya, Emily A. Martin

All Peer-Reviewed Publications

The push-pull technology (PPT) has often been presented as a management strategy for stemborers and witchweed. However, its value as an agronomic practice and an agroecological approach remains largely underappreciated. This review aims to appraise the PPT used in eastern Africa, synthesize evidence for its ecological and economic benefits, and identify barriers to its adoption and opportunities for its expansion to other crops and farming systems in sub-Saharan Africa.

Advancing Trypanosoma Cruzi N-Myristoyltransferase As A Drug Target For Chagas Disease Through In Silico Discovery And Biochemical Evaluation, Diana Citlali González García

Open Access Theses & Dissertations

Chagas disease remains one of the most persistent and neglected parasitic infections in the Americas, advancing silently through the intracellular replication of Trypanosoma cruzi amastigotes and the invasive spread of trypomastigotes. The survival of the parasite is critically reliant on protein N-myristoylation, a lipid modification catalyzed by N-myristoyltransferase (NMT). This dissertation aims to advance beyond prior studies by systematically investigating NMT inhibition across multiple biological levels, spanning from the characterization of the purified enzyme, through cellular infection models, to the global proteomic remodeling induced within the parasite, thereby evaluating TcNMT as a potential therapeutic vulnerability in T.cruzi.Recombinant TcNMT was expressed, …

Desmadre, Xiomarra Milann Gonzalez

Open Access Theses & Dissertations

My project functions as a collection of poems that each hold stories that tie them into the theme of their assigned subsection and into the greater narrative that each subsection creates, resulting in the takeaway from the overall manuscript. From the first word of the introductory poem, to the final line of the concluding, the poems take you on a journey from a feminine existence that is struggling at the helm of external, oppressive forces leading into a self-reckoning and embracing their own internal power within the systematic chaos and uncertainty that plagues them through the underlying notes of each …

Calibration Of Low-Cost Pm2.5 Sensors Using Data Continuously Generated At A Reference Station In El Paso, Texas, Brenda Lizbeth Hernandez

Open Access Theses & Dissertations

Low-cost sensors (LCS) offer a cost-effective way to expand air-quality monitoring networks, but they require strong calibration methods to ensure reliable performance under changing environmental conditions. In this study, Clarity LCSs were co-located with a state reference monitor for 6 months to evaluate fixed-time (2-, 3-, 4-, and 6-week) and rolling (2- and 3-week) calibration approaches. A multivariate regression model using PM1, PM2.5, PM10, and relative humidity was used to generate calibration coefficients for a “base sensor.” Data from two additional sensors were normalized to the base unit using linear regression, and their calibration coefficients were applied across the network. …

The Misadventures Of Popcorn And Zelda, Lori Lynne Kullberg

Open Access Theses & Dissertations

The Value of Animal Protagonists for Young Readers in Children’s Literature. This series is about my rescue cat and dog, Popcorn and Zelda, who are brought together at different ages and stages of their life. Witnessing their sweet interaction, mischievous playfulness, and close bond, I am immediately provided the inspiration for the early reader series of my thesis, The Misadventures of Popcorn and Zelda. My animals offer a constant stream of entertainment in watching how they interact with not only one another, but with me, as well. Oftentimes, Popcorn and Zelda’s behavior mirrors how I think a person would act …

A Half Century Of Biophysical Change In Polygonized Tundra On The Coastal Plain Of Northern Alaska, Mariana Mora

Open Access Theses & Dissertations

Climate change is amplified in the Arctic. As a result, Arctic tundra landscapes are undergoing physical changes through accelerated thaw and ice-wedge degradation. Understanding the magnitude and direction of these changes in the Arctic is a necessary step toward understanding the response of the Arctic to climate change and feedbacks to the Climate System. Through repeat measurements collected from 1973 through 2018, we were able to assess decadal time scale changes in polygon geomorphology, thaw depth, land surface compression and expansion, and vertical elevation within a highly polygonized tundra system, and their implications when scaled to a regional level. This …

Expression And Purification Of Prohibitin Proteins And Investigation Of Their Interaction With Mycobacterium Tuberculosis’S Virulence Factors, Zeina Rhaim

Open Access Theses & Dissertations

Prohibitin (PHB) is a highly conserved mitochondrial protein involved in cell cycle regulation, apoptosis, mitochondrial integrity, macrophage activation, cytokine production and many other critical cell functions. The prohibitin complex, formed by Prohibitin-1 (PHB1) and Prohibitin-2 (PHB2), functions as a mitochondrial membrane-associated receptor. Cancer, neurodegenerative disorders, and renal conditions were found to be linked to an irregular PHB expression. Emerging evidence has also highlighted a significant role for PHB in tuberculosis (TB), particularly through its interactions with Mycobacterium tuberculosis (Mtb) virulence determinants. The molecular mechanisms by which PHB influences TB pathogenesis remain poorly understood. Our preliminary studies showed that PHB1 was …