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Innovating The Electoral Experience: A Public Service Design Study Of Taiwan's Electoral System, Mu-En Lin, Li-Ning Huang, Chih-Lu Lin, Junyu Chen, Nai-Wen Fan, Shu-Ting Ai, Chi-Yi Chang Dec 2025

Innovating The Electoral Experience: A Public Service Design Study Of Taiwan's Electoral System, Mu-En Lin, Li-Ning Huang, Chih-Lu Lin, Junyu Chen, Nai-Wen Fan, Shu-Ting Ai, Chi-Yi Chang

IASDR Conference Series

This study adopts a public service design perspective to address the lack of professional design involvement in Taiwan’s election system. Within the constraints of existing laws and administrative procedures, the research proposes feasible, immediately applicable optimization strategies. Through cross-sector collaboration with the Central Election Commission, the study focuses on key voter-facing elements—such as election bulletins, polling station signage, and voting booths—introducing standardized, templated, and modular designs to resolve systemic issues like visual clutter and operational inefficiency. Using methods including user journey analysis, institutional research, and prototype testing, the project combines SOP guidelines and digital tools to improve information clarity and …


Avian Experience In Urban Grotto: Ecological Soundscapes As A Biosemiotic Methodology In Multispecies Ethnographic Research And More-Than-Human Communication, Qingyu Zhang, Francesca Valsecchi Dec 2025

Avian Experience In Urban Grotto: Ecological Soundscapes As A Biosemiotic Methodology In Multispecies Ethnographic Research And More-Than-Human Communication, Qingyu Zhang, Francesca Valsecchi

IASDR Conference Series

Ecological soundscapes, once primarily regarded as carriers of environmental information, are increasingly understood as immersive, embodied experiences that offer experiential and ontological access to more-than-human worlds. Situated within the framework of more-than-human design, this research challenges anthropocentric paradigms by foregrounding ecological soundscapes as dynamic, sentient agencies that convey environmental meaning and social structures among non-human species. Through field-based, autoethnographic inquiry on crow vocal is ation in Vienna, the project 1) articulates a hybrid methodological approach combining deep listening, soundscape walks, and bio acoustic analysis; and 2) establishes a sonification process that translates the data from the multispecies ethnographic research into …


The Choreography Of Sympoiesis: A Speculative Design To Reshape Modern Equestrian Concepts, Heyu Shao Dec 2025

The Choreography Of Sympoiesis: A Speculative Design To Reshape Modern Equestrian Concepts, Heyu Shao

IASDR Conference Series

This study explores the interactive relationship between humans and horses in equestrian practice, proposing that through long-term coexistence and riding, humans are not only tamers but are also shaped by horses. Using speculative design, the author created two new equestrian devices—the “Sym- Bridle” and the “WaveSync Saddle”—to visualize and amplify the subtle flows of force and sensory feedback between rider and horse. These works challenge the notion of one-way control, reframing riding as a process of mutual adjustment and embodied dialogue. Building on this, the author introduces the post-human figure “Equiarch”, imagining the bodily, behavioral, and cognitive transformations emerging from …


Climate Change Influence On The Distribution Of Four Plant Medicinal Species From The Sierra Norte Of Oaxaca, Mexico, Irene Bautista Juárez, José Luis Villaseñor, Monserrat Vázquez-Sánchez, Wenceslao Santiago-García, Faustino Ruiz-Aquino, Mario Ernesto Suárez-Mota Dec 2025

Climate Change Influence On The Distribution Of Four Plant Medicinal Species From The Sierra Norte Of Oaxaca, Mexico, Irene Bautista Juárez, José Luis Villaseñor, Monserrat Vázquez-Sánchez, Wenceslao Santiago-García, Faustino Ruiz-Aquino, Mario Ernesto Suárez-Mota

Neotropical Biodiversity

The Sierra Norte of Oaxaca, México, because of its high biodiversity, is a good candidate for studying the possible effects of climate change on its flora distribution. Currently, several modelling tools have been developed to facilitate the prediction of present and future species distribution. The objective of this study is to evaluate the impact of climate change on the distribution of four locally important medicinal plant species from the Asteraceae family (Heterotheca inuloides, Laennecia filaginoides, Pinaropappus roseus, and Tagetes lucida). The analysis was done using the maximum entropy algorithm under three different time periods: the present, 2050, and …


Ai Companions And The Lessons Of Family Law, Clare Huntington Dec 2025

Ai Companions And The Lessons Of Family Law, Clare Huntington

Minnesota Law Review Vols. 106:2 onward (2021-present)

Virtual friends and lovers powered by artificial intelligence are rapidly moving to the center of our emotional and social lives. Millions of people turn to AI companions every day for conversation, romance, sexual intimacy, therapy, and education. AI companionship holds promise, potentially reducing loneliness, supporting people without access to mental health treatment, helping students learn, and offering a judgment-free space for sensitive conversations. But AI companionship also raises significant concerns. The technology’s addictiveness may exacerbate loneliness and can undermine human relationships. Therapy bots may prove more harmful than helpful. AI companions can be emotionally abusive. And their access to the …


Dairy And Food Science Student Newsletter, December 2, 2025, Department Of Dairy And Food Science Dec 2025

Dairy And Food Science Student Newsletter, December 2, 2025, Department Of Dairy And Food Science

Dairy and Food Science Student Newsletter

No abstract provided.


The Effect Of Diet-Derived Thiaminase On Survival, Growth, And Liver Transketolase Activity In Two Strains Of Lake Trout (Salvelinus Namaycush), Christian A. Therrien, Peter M. Baker, Shawn R. Garner, Patricia C. Wolfe, Sarah Matesic, Katie A. Edwards, Chris C. Wilson, Heidi K. Swanson, Bryan D. Neff Dec 2025

The Effect Of Diet-Derived Thiaminase On Survival, Growth, And Liver Transketolase Activity In Two Strains Of Lake Trout (Salvelinus Namaycush), Christian A. Therrien, Peter M. Baker, Shawn R. Garner, Patricia C. Wolfe, Sarah Matesic, Katie A. Edwards, Chris C. Wilson, Heidi K. Swanson, Bryan D. Neff

Pharmacy Faculty Scholarship

The consumption of invasive, high-thiaminase prey fishes can cause thiamine deficiency, which has been hypothesized to be a major barrier for lake trout (Salvelinus namaycush) restoration in the Laurentian Great Lakes. Here, we compared the effects of diet-derived thiaminase on survival and performance-related traits between two strains of lake trout that differ in historical exposure to thiaminase. Juvenile lake trout from the Seneca Lake (higher historical exposure to thiaminase) and Slate Islands (lower historical exposure) strains were reared in a common garden environment and received either an experimental diet containing bacterial derived-thiaminase or a control diet. Six months after the …


Hogfish (Lachnolaimus Maximus) Neurocranium, Nate B. Nutting-Hartman, Naya H. Mondrosch, David W. Kerstetter Dec 2025

Hogfish (Lachnolaimus Maximus) Neurocranium, Nate B. Nutting-Hartman, Naya H. Mondrosch, David W. Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.


December 2025 Faculty Senate Packet, University Of Nebraska At Kearney Faculty Senate Dec 2025

December 2025 Faculty Senate Packet, University Of Nebraska At Kearney Faculty Senate

Faculty Senate Packets

No abstract provided.


Pensar Desde Los Márgenes: Travesías Teológicas Desde Cuerpos, Fronteras Y Disidencias En La Obra De Hugo Córdova Quero, Anderson Fabián Santos Meza Dec 2025

Pensar Desde Los Márgenes: Travesías Teológicas Desde Cuerpos, Fronteras Y Disidencias En La Obra De Hugo Córdova Quero, Anderson Fabián Santos Meza

Conexión Queer: Revista Latinoamericana y Caribeña de Teologías Queer

This essay offers an interpretive reading of Hugo Córdova Quero’s theological work from a third-person perspective, avoiding a laudatory or autobiographical tone. Based on queer and decolonial Trinitarian theology, the text traces a path that articulates biblical hermeneutics, migration studies, popular culture, queer theory, and pastoral praxis. The work is read as a relational and pilgrimage project. In this difference, displacement, and violated bodies do not constitute a theological problem, but rather an epistemic place from which to rethink the sacred, community, and justice.


Cartografías Del Que(R)Er: Subjetividades En Tránsito Y Creación, Dan González-Ortega Dec 2025

Cartografías Del Que(R)Er: Subjetividades En Tránsito Y Creación, Dan González-Ortega

Conexión Queer: Revista Latinoamericana y Caribeña de Teologías Queer

I propose insights into a theology in motion that maps «Wanting» [que(r)er]—love, desire, and the search for a whole life—amid multiple transitions: forced migrations, the climate crisis, queer and digital (epochal) subjectivities. From a territorial and incarnate biblical hermeneutic, I reread Scripture from the perspective of marginalized bodies and territories. I integrate feminist, postcolonial, and posthumanist contributions to think of creation as living territoriality and subjectivity of revelation. Human mobility and the wounded Earth are understood as intertwined cries that challenge the world. I present a potential open spiral of communion, in which all subjectivity—human and more-than-human—is welcomed …


Longitudinal Pharmacokinetic And Safety Studies Of An Antibody-Erythropoietin Fusion Protein For Alzheimer's Disease, Rudy Chang, Devaraj Venkatapura Chandrashekar, G. Chuli Roules, Nataraj Jagadeesan, Emi Iwasaki, Adenike Oyegbesan, Hayk Davtyan, Rachita K. Sumbria Dec 2025

Longitudinal Pharmacokinetic And Safety Studies Of An Antibody-Erythropoietin Fusion Protein For Alzheimer's Disease, Rudy Chang, Devaraj Venkatapura Chandrashekar, G. Chuli Roules, Nataraj Jagadeesan, Emi Iwasaki, Adenike Oyegbesan, Hayk Davtyan, Rachita K. Sumbria

Pharmacy Faculty Articles and Research

Erythropoietin (EPO) shows promise for Alzheimer's disease (AD) but has poor brain penetration, necessitating high doses that cause hematopoietic side effects. To improve brain delivery, EPO was fused to a transferrin receptor monoclonal antibody (TfRMAb), and this study evaluated the pharmacokinetics (PK), safety, and efficacy of repeated TfRMAb-EPO dosing in mice to further its preclinical development. C57BL/6J male mice (10 weeks old, n = 4–5/dose) received subcutaneous (SQ) low (1 mg/kg), mid (3 and 6 mg/kg), or high (20 mg/kg) TfRMAb-EPO doses for 4 weeks. The 1 mg/kg dose showed no adverse effects and resulted in sustained brain and plasma …


Redefining Resistance: Las Madres De La Plaza De Mayo, Echoes Of Trauma And Memory In Argentina, Elizabeth J. Kaye Dec 2025

Redefining Resistance: Las Madres De La Plaza De Mayo, Echoes Of Trauma And Memory In Argentina, Elizabeth J. Kaye

Honors Theses

Argentina's "Dirty War" (1976–1983) stands as one of the darkest and most painful periods in the nation’s history. During these years, the military dictatorship, known as the "Proceso de Reorganización Nacional," implemented a systematic campaign of state terrorism, targeting suspected political protesters, activists, intellectuals, and ordinary citizens. Widespread kidnappings, illegal detentions, and forced disappearances became routine, with an estimated 30,000 people vanishing without a trace. Families were left in despair, searching for answers that the government refused to provide. In response, a group of determined mothers, known as “Las Madres de la Plaza de Mayo”, formed a powerful movement demanding …


Edna Surveys For The Critically Endangered Caribbean Staghorn Coral, Acropora Cervicornis (Lamarck, 1816), Pari Elaine Cribbins Dec 2025

Edna Surveys For The Critically Endangered Caribbean Staghorn Coral, Acropora Cervicornis (Lamarck, 1816), Pari Elaine Cribbins

All HCAS Student Capstones, Theses, and Dissertations

Historically, Acropora cervicornis was a dominant coral on Caribbean reef systems, but an outbreak of white band disease in the late 1970s marked the beginning of devastating, multi-decadal population declines that led to the coral being listed as “critically endangered” on the IUCN Red List in 2022. Today, after a record-setting marine heat wave in 2023 triggered a mass bleaching event on Florida’s Coral Reef (FCR), A. cervicornis is considered functionally extinct on the FCR. While individuals of A. cervicornis do remain on the FCR, the small population size of the coral makes in situ surveys difficult. However, surveys using …


A Burlesque: The Shimmering Body Of Revealing, Lola Montgomery Dec 2025

A Burlesque: The Shimmering Body Of Revealing, Lola Montgomery

Staff Scholarship - Australia & Dubai

A Burlesque: The Shimmer Manuscript is a hybrid critical–creative work that examines burlesque as an embodied methodology and a mode of knowledge production. Drawing from my two decades as a performer–scholar, the work reframes glamour, desire, and adornment as epistemological practices rather than theatrical ornamentation. The project is significant in that it expands understandings of performance studies, autotheory, and feminist aesthetics by foregrounding the performer’s body as an intelligent, sensing, world-making apparatus.

The methodology is creative practice research and archive-driven, integrating backstage documentation, AI-assisted photomontage, and theoretical reflection. The work draws from poststructuralist and feminist frameworks (Irigaray, Deleuze & Guattari, …


Line Transect Surveys And Initial Estimates Of Abundance For Sea Turtles In Biscayne National Park, Florida., Kathryn C. Price Dec 2025

Line Transect Surveys And Initial Estimates Of Abundance For Sea Turtles In Biscayne National Park, Florida., Kathryn C. Price

All HCAS Student Capstones, Theses, and Dissertations

The loggerhead (Caretta caretta) and green (Chelonia mydas) turtle are two species of marine megafauna that have suffered abundance declines due to increased anthropogenic pressures. Assessing the distribution and abundance of sea turtles is essential for conserving and managing these imperiled species; however, assessing sea turtle populations poses difficulties due to the sea turtles’ highly migratory nature. Distance sampling surveys are extensively used to study populations of wide-ranging species. In this study, vessel-based line transect survey data collected throughout 2024 were used to estimate overall and seasonal sea turtle abundances and distribution throughout Biscayne National Park, …


What Is A Nativity Set?, Bridget Retzloff Dec 2025

What Is A Nativity Set?, Bridget Retzloff

Marian Library Blog Archive

Learn about a tradition that helps people to imagine the birth of Christ.


Using Gnotobiotic Mice To Decipher Effects Of Gut Microbiome Repair In Undernourished Children On Tuft And Goblet Cell Function, Yi Wang, Hao-Wei Chang, Jiye Cheng, Daniel M Webber, Hannah M Lynn, Matthew C Hibberd, Clara Kao, Ishita Mostafa, Tahmeed Ahmed, Michael J Barratt, Jeffrey I Gordon Dec 2025

Using Gnotobiotic Mice To Decipher Effects Of Gut Microbiome Repair In Undernourished Children On Tuft And Goblet Cell Function, Yi Wang, Hao-Wei Chang, Jiye Cheng, Daniel M Webber, Hannah M Lynn, Matthew C Hibberd, Clara Kao, Ishita Mostafa, Tahmeed Ahmed, Michael J Barratt, Jeffrey I Gordon

2020-Current year OA Pubs

Studies have implicated perturbations in the postnatal development of the gut microbiome as a contributing factor to childhood undernutrition. Compared to a standard ready-to-use supplementary food, a microbiome-directed complementary food (MDCF-2) designed to repair these perturbations produced superior improvements in ponderal and linear growth in clinical trials of Bangladeshi children with moderate acute malnutrition. Here, "reverse translation" experiments are performed where intact fecal microbiomes collected from trial participants before and at the end of treatment are introduced into female gnotobiotic mice just after delivery of their pups. Pups received diets designed to resemble those consumed by children in the trials …


Activation Of Pro-Regenerative Gene Programs In The Mature Central Nervous System, Elizabeth Carlisle Batsel Dec 2025

Activation Of Pro-Regenerative Gene Programs In The Mature Central Nervous System, Elizabeth Carlisle Batsel

Dissertations (1934 -)

Spinal cord injury (SCI) affects millions of people worldwide. Damage to the spinal cord disrupts the long-distance axon tracts of central nervous system (CNS) neurons. These axons fail to regenerate, leading to permanent dysfunction. Past work has shown that CNS neurons lose the capacity to elongate their axons as they mature. Conversely, after injury, embryonic and peripheral nervous system (PNS) neurons can elongate axons towards target cells, driven by the growth cone at the growing tip of the axon. Previous research has identified transcription factor (TF) families, such as the SoxC family, that contribute to embryonic and peripheral neurons’ high …


Teacher Candidates’ Attempts To Implement Anti-Ableist Pedagogy And The Constraints Therein, Benjamin Barnett-Perry Dec 2025

Teacher Candidates’ Attempts To Implement Anti-Ableist Pedagogy And The Constraints Therein, Benjamin Barnett-Perry

Northwest Journal of Teacher Education

In this qualitative study, I interviewed four special education teacher candidates with a stated interest in enacting anti-ableist pedagogy in their student teaching placements. I drew on Holland et al.’s (1998) figured worlds to examine their attempts to enact anti-ableist pedagogy in their classrooms and their navigation of the hierarchy within their placements. Participants entered their student teaching eager to implement anti-ableist pedagogy. However, their attempts at implementation were often met with pushback from a variety of sources and a new understanding of how much they could actually accomplish from their place at the bottom of the school hierarchy. Findings …


Global, Regional, And National Burden Of Cardiovascular Diseases And Risk Factors In 204 Countries And Territories, 1990-2023, Global Burden Of Cardiovascular Diseases And Risks 2023 Collaborators, Benjamin A. Stark, Nicole K. Decleene, Emily C. Desai, Johnathan M. Hsu, Catherine O. Johnson, Laura Lara-Castor, Kate E. Legrand, Prof Bhoomadevi A, Mohammad Amin Aalipour, Hasan Aalruz, Bedru J. Abafita, Ukachukwu O. Abaraogu, Mohammad Abavisani, Nasir Abbas, Madineh Abbasi, Mohammadreza Abbasian, Hedayat Abbastabar, Abdallah H.A. Abd Al Magied, Samar Abd Elhafeez, Prof Ahmed Abdelalim, Omar M. Abdelfattah, Prof Reda Abdel-Hameed, Mahmoud Abdelnabi, Prof Wael M Abdel-Rahman, Parsa Abdi, Wakgari Mosisa Abdisa, Daba Abdissa, Arman Abdous, Mujahid Abdullah Dec 2025

Global, Regional, And National Burden Of Cardiovascular Diseases And Risk Factors In 204 Countries And Territories, 1990-2023, Global Burden Of Cardiovascular Diseases And Risks 2023 Collaborators, Benjamin A. Stark, Nicole K. Decleene, Emily C. Desai, Johnathan M. Hsu, Catherine O. Johnson, Laura Lara-Castor, Kate E. Legrand, Prof Bhoomadevi A, Mohammad Amin Aalipour, Hasan Aalruz, Bedru J. Abafita, Ukachukwu O. Abaraogu, Mohammad Abavisani, Nasir Abbas, Madineh Abbasi, Mohammadreza Abbasian, Hedayat Abbastabar, Abdallah H.A. Abd Al Magied, Samar Abd Elhafeez, Prof Ahmed Abdelalim, Omar M. Abdelfattah, Prof Reda Abdel-Hameed, Mahmoud Abdelnabi, Prof Wael M Abdel-Rahman, Parsa Abdi, Wakgari Mosisa Abdisa, Daba Abdissa, Arman Abdous, Mujahid Abdullah

Peninsula Medical School

Background: Cardiovascular diseases (CVDs) are the leading cause of mortality and are among the foremost causes of disability globally. CVD burden has continued to increase in most countries since 1990, with trends driven by changing exposures to harmful risk factors, population growth, and population aging. Objectives: We report estimates of global, national, and subnational CVD burden, including 18 subdiseases and 12 associated modifiable risk factors. We analyzed change in CVD burden from 1990 to 2023 and identified drivers of change including population growth, population aging, and risk factor exposure. Methods: The Global Burden of Disease (GBD) 2023 study, a multinational …


The Triangular Interaction Between Dietary Polyphenols, Gut Microbiota, And Metabolic Syndrome, Emily Bayliss Dec 2025

The Triangular Interaction Between Dietary Polyphenols, Gut Microbiota, And Metabolic Syndrome, Emily Bayliss

Senior Honors Theses

Type 2 diabetes mellitus (T2DM) is a growing global health concern characterized by peripheral insulin resistance as well as impaired insulin secretion from pancreatic β-cells. Emerging evidence suggests that the gut microbiome, specifically gut dysbiosis, an imbalance in the gut microbiome, is a critical modulator of the pathophysiology of T2DM. Dietary polyphenols, a diverse group of bioactive compounds that are abundant in plant-based foods, have recently gained attention for their potential to attenuate metabolic disorders through their antioxidant and anti-inflammatory properties as well as through modulating the composition and activity of gut microbes, thereby attenuating dysbiosis. However, the diabetic state …


T Cell Senescence And Nociplastic Pain: A Proposed Etiological Mechanism, Kayla S. Riggleman Dec 2025

T Cell Senescence And Nociplastic Pain: A Proposed Etiological Mechanism, Kayla S. Riggleman

Senior Honors Theses

Nociplastic pain is a newly identified chronic pain phenotype characterized by widespread hyperalgesia and allodynia. Its etiological mechanisms are currently unknown, making medical intervention elusive. The proposed pathophysiological model connects immunosenescence with a degradation of the blood-brain barrier as a result of peripheral inflammation. Neuronal hyperexcitability and glial cell activation result, leading to nociplastic pain. It is currently thought that central sensitization is the key mechanistic driver of nociplastic pain, so this literature review seeks to expound on that. Based on this framework, chimeric antigen receptor (CAR)-T cell therapy and stem cell treatments are proposed therapeutic methodologies to be explored. …


Investigating The Mechanisms By Which Gut Microbiome Dysbiosis Contributes To The Autoimmune Response In Multiple Sclerosis, Abigail Houtrouw Dec 2025

Investigating The Mechanisms By Which Gut Microbiome Dysbiosis Contributes To The Autoimmune Response In Multiple Sclerosis, Abigail Houtrouw

Honors Theses

This literature review explores the multifaceted relationship between gut microbiome (GM) dysbiosis and multiple sclerosis (MS), highlighting key themes that advance understanding of disease pathogenesis and therapeutic potential for treatments targeting the gut. The review underscores the immune system dysregulation in MS, emphasizing the roles of T cells, B cells, and microglia in neuroinflammation and demyelination. Historically, MS pathogenesis was thought to be driven mainly by T-cell dysregulation, but current research highlights the additional roles of B-cells and microglia, the resident immune cells of the central nervous system (CNS). Additionally, this literature review identifies GM alterations and dysbiosis as critical …


Christmas Calories And Hallmark Movies, Mark Volkers Dec 2025

Christmas Calories And Hallmark Movies, Mark Volkers

Faculty Work Comprehensive List

"Christmas is a great time to indulge in a few sweets, while also enjoying hearty meals that give us strength for the new year to come."

Posting about ­­­­­­­­balancing seasonal comforts with faithful living from In All Things, an online hub that offers insight into maintaining and faithful and orthodox Reformed Christian worldview while fearlessly engaging in every aspect of contemporary life – until all is made new.

Christmas Calories and Hallmark Movies


Inhibition Of Clostridioides Difficile-Specific Dna Adenine Methyltransferase Cama By Analogs Of S‑Adenosyl‑L‑Methionine, Jujun Zhou, Youchao Deng, Dan Yu, Taraneh Hajian, Masoud Vedadi, Xing Zhang, Robert M Blumenthal, Rong Huang, Xiaodong Cheng Dec 2025

Inhibition Of Clostridioides Difficile-Specific Dna Adenine Methyltransferase Cama By Analogs Of S‑Adenosyl‑L‑Methionine, Jujun Zhou, Youchao Deng, Dan Yu, Taraneh Hajian, Masoud Vedadi, Xing Zhang, Robert M Blumenthal, Rong Huang, Xiaodong Cheng

Faculty, Staff and Student Publications

Epigenetically targeted therapies, especially those inhibiting S-adenosyl-l-methionine (SAM)-dependent methylations of DNA, mRNA, and histones, have advanced rapidly in cancer treatment. However, these therapies remain underexplored for antibiotic development, despite the growing threat of antimicrobial resistance. Here, we screened a focused library of SAM analogs against the DNA adenine methyltransferase CamA specific to the enteric pathogen Clostridioides difficile. At the same time, we examined six other adenine methyltransferases, including two bacterial DNA methyltransferases and four human RNA methyltransferases having distinct RNA substrates. Compound 113 selectively inhibited CamA (IC50 = 0.15 μM). In addition, compound 67 inhibited Caulobacter crescentus CcrM …


Hif-2-Dependent Regulation Of Pthrp And Paraneoplastic Hypercalcemia In Aggressive Clear-Cell Renal Cell Carcinoma, Arijit Mal, Bingqing Xie, Zane Gray, Charlotte Small, Susmita G Ramanand, Yunpeng Gao, Vanina Toffessi Tcheuyap, Sashi Debnath, Alana Christie, Jeffrey Miyata, Brooklyn Jackson, Hua Zhong, Boning Gao, Jay Lohrey, Naim M Maalouf, Sangeetha M Reddy, John D Minna, Ivan Pedrosa, Xiankai Sun, Ram S Mani, Payal Kapur, James Brugarolas Dec 2025

Hif-2-Dependent Regulation Of Pthrp And Paraneoplastic Hypercalcemia In Aggressive Clear-Cell Renal Cell Carcinoma, Arijit Mal, Bingqing Xie, Zane Gray, Charlotte Small, Susmita G Ramanand, Yunpeng Gao, Vanina Toffessi Tcheuyap, Sashi Debnath, Alana Christie, Jeffrey Miyata, Brooklyn Jackson, Hua Zhong, Boning Gao, Jay Lohrey, Naim M Maalouf, Sangeetha M Reddy, John D Minna, Ivan Pedrosa, Xiankai Sun, Ram S Mani, Payal Kapur, James Brugarolas

Faculty, Staff and Student Publications

Renal cell carcinoma (RCC) patients with hypercalcemia (HC) have worse outcomes. HC often involves PTHrP, and the role of HIF-2 is incompletely understood. Leveraging RCC tumorgraft (TG) models of HC, which were characterized by tumor cell autonomous inflamatory/immune signatures, we show that HIF-2 inhibition with PT2399 frequently normalized calcium, downregulated circulating PTHrP and reduced HIF-2 binding to the PTHLH (PTHrP) promoter. Likely contributing to the selective induction of PTHrP in a subset of HIF-2-dependent tumors, the PTHLH locus was generally more accessible in TG(HC). However, PTHLH chromatin accessibility was grossly unaffected by PT2399, unlike elsewhere (including EPO locus in a …


Between The Calm Lake Waters, Adrian Martinez Dec 2025

Between The Calm Lake Waters, Adrian Martinez

Honors Theses

No abstract provided.


The Prospector, December 2, 2025, Utep Student Publications Dec 2025

The Prospector, December 2, 2025, Utep Student Publications

The Prospector

No abstract provided.


Single Compost Application Benefits For Organic Dryland Wheat Production, Shikha Sharma, Matt Yost, Earl Creech, Jennifer R. Reeve, Astrid R. Jacobson, Idowu Ademola Atoloye Dec 2025

Single Compost Application Benefits For Organic Dryland Wheat Production, Shikha Sharma, Matt Yost, Earl Creech, Jennifer R. Reeve, Astrid R. Jacobson, Idowu Ademola Atoloye

All Current Publications

This research highlights the long-term value of compost in dryland wheat systems, where water scarcity and declining soil fertility limit productivity. A single, high-rate compost application (22 tons per acre) can improve soil moisture content, organic carbon content, aggregate stability, and microbial activity. All these benefits contributed to higher and more stable wheat yields, even more than two decades after application. These changes help to make the compost-treated wheat more resilient during dry years. While composting incurs a high upfront cost, its long-term benefits can significantly reduce the need for repeated fertilizer or soil amendments, offering cost and labor savings …