Digital Commons Network^™

Revealing The Nervous System Requirements Of Alzheimer Disease Risk Genes In Drosophila, Jennifer M Deger, Shabab B Hannan, Mingxue Gu, Colleen E Strohlein, Lindsey D Goodman, Sasidhar Pasupuleti, Zahid Shaik, Liwen Ma, Yarong Li, Jiayang Li, Morgan C Stephens, Michal Tyrlík, Zhandong Liu, Ismael Al-Ramahi, Juan Botas, Chad A Shaw, Oguz Kanca, Hugo J Bellen, Joshua M Shulman

Faculty, Staff and Students Publications

Most Alzheimer disease (AD) susceptibility genes have poorly understood roles in the central nervous system (CNS). To address this gap, we systematically characterized 100 conserved candidate AD risk genes using a cross-species strategy in the fruit fly, Drosophila melanogaster. Genes were prioritized based primarily on human functional genomic evidence. We generated custom loss-of-function alleles for each of the conserved fly orthologs. Most of the genes are expressed in the adult brain, including 24 neuron- and 13 glia-specific expression patterns. Overall, we identify 50 candidate AD risk gene homologs with requirements for CNS structure or function, including 18 whose loss of …

Super-Fast, Super-Early: High-Frequency Oscillations May Be A Prelude To Alzheimer's Dementia In Down Syndrome, Manuel Silva-Pérez, Jeannie Chin

Faculty, Staff and Students Publications

Alzheimer's disease (AD) dementia has near full penetrance in adults with Down syndrome (DS) and is strongly linked to late-onset myoclonic epilepsy in Down syndrome (LOMEDS). However, promising biomarkers of epileptogenicity, such as high-frequency oscillations (HFOs >250 Hz), have not been studied. This study is the first to use wideband polysomnography in DS to investigate if HFOs occurred and preceded AD dementia and LOMEDS. Methods: Wideband (0.1 to 500 Hz, 2048 Hz) polysomnography was performed using the international 10–20 system. HFOs were automatically detected during slow-wave sleep, followed by manual review. Results: Fourteen individuals with DS and five age-matched euploid …

The Clinical Pharmacogenetics Implementation Consortium's Consensus-Based Framework For Assigning Allele Function., Bailey M. Tibben, Andrea Gaedigk, Li Gong, Katrin Sangkuhl, Michelle Whirl-Carrillo, Mary V. Relling, Roseann S. Donnelly, Teri E. Klein, Kelly E. Caudle

Manuscripts, Articles, Book Chapters and Other Papers

The Clinical Pharmacogenetics Implementation Consortium (CPIC) is dedicated to integrating pharmacogenetic testing into clinical practice by developing and disseminating peer-reviewed, evidence-based gene-drug clinical practice guidelines. A critical component of this effort is the assignment of clinical function to pharmacogene alleles, which informs the translation of genetic test results into actionable prescribing decisions. This technology review outlines the standardized procedures and framework used by CPIC to assign allele clinical functional status through the work of Pharmacogene Curation Expert Panels (PCEPs). These panels, comprising multidisciplinary experts, systematically review and evaluate evidence to assign functional status to pharmacogenetic haplotypes. The process includes rigorous …

Toward A Roadmap For Addressing Today's Health Dilemma-The 101-Statement Consensus Report, Katharina C. Wirnitzer, Mohamad Motevalli, Derrick R. Tanous, Clemens Drenowatz, Maximilian Moser, Holger Cramer, Thomas Rosemann, Karl-Heinz Wagner, Andreas Michalsen, Beat Knechtle, Zlatko Fras, Merel Ritskes-Hoitinga, Adilson Marques, Natasa Fidler Mis, Fatima C. Stanford, Christian Schubert, Nandu Goswami, Claus Leitzmann, Per Morten Fredriksen, Gerhard Ruedl, Doris Wilflingseder, Rodrigo A. Lima, Christian Kessler, Michael Jeitler, Naim A. Khan, Hassan Joulaei, Maryam Fatemi, Andrew Knight, Karl W. Kratky, Kara K. Palmer

School of Health Professions

Importance: In recent decades there has been an expansion in the quantity and quality of scientific findings and guidelines on different health topics to promote individual and public health status. Reports also indicate that there has been a simultaneous increase in the financial burden of disease, including trillions spent on healthcare resources by governments worldwide (predominantly in developing countries) to address health concerns. At the same time, personal health behavior is well-known as efficient and cost-free, holding four times the potential to prevent early death compared to health care. Despite this knowledge, data show that the increasing prevalence of unhealthy …

2017 Rocky Mountain National Park Research Conference, United States Department Of Interior

Rocky Mountain National Park

The work highlighted by this conference addresses key issues, including climate change, the spread of exotic plants, large scale restoration needs, environmental contaminants and disease, a need for greater relevancy to youth, and inadequate capacity to keep pace with growing visitation. The NPS Director's Order "Resource Stewardship for the 21st Century" directs park managers to steward resources for continuous change that is not yet fully understood. This challenge makes research, learning, and engagement at local to global scales more important than ever. The magnitude of issues and opportunities currently facing park managers is reflected in the breadth and depth of …

Mountaineering In The Rocky Mountain National Park, Roger Toll, Robert Sterling Yard

Rocky Mountain National Park

Mountaineering in the Rocky Mountain National Park: Including a Map of the Park Circa 1917 and Various Photos

Olmstead, Frederick; Porter, Elliot; Powell, John Wesley; Rearick, Dave; Roosevelt, Teddy; Salaun, Milton; Shoup, Oliver; Stettner, Joe; Stettner, Paul; Toll, Roger; Ullman, James Ramsey; Vasille, Agnes Wolcott; Walker, Kris; Wallace, George; Wharton, John; Wirth, Conrad; Zimmerman, Weerner; Rocky Mountain National Park; Steads ranch; Steads Hotel; Estes Park; Cave of the Winds; Trail Ridge Road; MacGregor Ranch; Grand Lake; Long's Peak; Continental Divide; Boulderfield Hotel; High Trail Map; Wild Basin; Tahosa valley; Vale of Elkanah; Long's Peak Hotel;

Rocky Mountain National Park: Historical Background Data, Ross Holland Jr.

Rocky Mountain National Park

A study undertaken to furnish historical background information Rocky Mountain National Park for master planning. Includes photographs and a map.

Adams, Henry; Adams, Jane; Baker, William; Bird, Isabella; Bryan, William Jennings; Byers, William; Chubbock, Clarence; Churchill, Hiram; Colfax, Schuler; Cudahy, Edward; Darrow, Clarence; Dickinson, Anna; Estes, Joel; Estes, Milton; Evans, Griffith; Fall, Albert; Farrell, Ned; Garman, Samuel; Gaskill, L. D. C.; Godsmark, Joseph; Hague, Arnold; Hayden, F. V.; Howard, J. E.; Huges, Charles Evans; King, Clarence; Lamb, E. J.; March, M. E.; Mather, Stephen; McKelvey, Russell; Mills, Enos; Moomaw, Jack; Nichols, George; Nugent. James; Powell, John Wesley; Rigdon, John; Roosevelt, …

Rocky Mountain Administrative History, United States Department Of Interior

Rocky Mountain National Park

This study contains the administrative history of Rocky Mountain National Park from its creation in 1915 to 1965, fifty years. It is divided thematically into 13 chapters and a conclusion.

Trowbridge, Charles; Way, Claude; Toll, Roger; Rogers, Edmund; Allen, Thomas; Canfield, David; Miller, George; Doer, John; Lloyd, James; Hanks, Allyn; Liles, Granville; Novak, Fredrick; Thompson, Theodore; Dunning, Jimmy; Long, Stephen H; Dodge, Henry; Freemont, John; Vasquez, Louis; Sublette, Andrew; Estes, Joel; Estes, Milton; Teller, Henry M; Hollenbeck, Michael; Byers, William; Griffith; MacGregor, Alexander; Ferguson, Horace; James, W. E; Sanborn, B. D.; Stanley, F.O.; Wescott, Joseph L.; Proctor, Alexander; Proctor, Tirzah; …

Rapid Ascent: Rocky Mountain National Park In The Great Acceleration: 1945-Present, Max Boxwell

Rocky Mountain National Park

A Master's Thesis asserting that wat-time technologies cheap fossil fuels, and a culture of techno-optimism—epitomized by the Mission 66 development program—helped foster a “Great Acceleration” of human alterations of Earth’s natural systems.

Abbey, Edward; Beau, Lucas; Braudel, Fernand; Carhart, Arthur; Collins, Kay; Condon, David; Contor, Robert; Crutzen, Paul; Fry, John; Guse, Neal; Hirt, Paul; Hughes, George; Keizer, Garret; Knous, Robert; Love, John Arthur; Menning, Edgar; Mills, Enos; Mooney, David; Noland, Jerry; Olson, Sigurd; Philpott, William; Redman, Mayme; Stoemer, Eugene; Sutter, Paul; Wirth, Conrad; Zalasiewicz, Jan; Leopold, Aldo; Rocky Mountain National Park; Rocky Mountains; Great Acceleration; Anthropocene; Spindletop; Tennessee Valley Authority; …

“River Of Death”: Industrial Pollution And The North Texas Trinity River Inthe Progressive Era, Meghan Scott-Chaber

Journal of Texas History

No abstract provided.

The Role Of Digital Media In The Promotion Of Cultural Heritage And Art, Arben Arifi

International Journal of Business and Technology

The goal of this paper is to provide an overview of how digital media are creating new conceptual and operational landscapes. On one hand, digital media are altering expectations regarding digital tools for both individuals and institutions. On the other hand, they are giving artists new opportunities to explore and innovate in their creative expressions. The question arises: Is culture merely our past, our roots, ancient artifacts, or historical art? Culture encompasses all the elements that shape our identity and influence how we behave and interact in various aspects of our lives both personal and public. It includes practices we …

Assessment Of Microbiological And Physicochemical Parameters In Ground Beef From Fast Food Outlets In The Prishtina Region, Diora Kastrati, Veton Haziri, Ibrahim Mehmeti, Violeta Lajqi Makolli, Arianeta Nura, Flutura C. Ajazi

International Journal of Business and Technology

Fast food consumption has significantly increased, particularly in fast-paced cities like Prishtina. Hamburgers, one of the most consumed products in this industry, rely on ground beef, which poses notable food safety risks due to potential contamination and inadequate hygiene practices. The aim of this study was to evaluate selected microbiological and physicochemical parameters in ground beef from fast food outlets in the Prishtina region. The research involved analyzing 12 samples from various fast-food establishments in Prishtina, collected during June-July 2024. Microbiological analyses focused on total mesophilic aerobic bacteria and Escherichia coli, using standard cultivation methods on Plate Count Agar and …

The Hidden Cost Of Metformin: Deficiency Of Vitamin B12 In Iraqi Patients With Type 2 Diabetes, Noor Mohammed Obaid, Halla Talib Salih, Mohammed Abdulzahra Hussein, Yousif M. I Al-Mohammed Amin, Mustafa Raheem Oglah

Maaen Journal for Medical Sciences

Background: Metformin remains a cornerstone in the management of type 2 diabetes mellitus. However, extended use has been increasingly linked to vitamin B12 deficiency, contributing to neuropathy, anemia, and cognitive impairment.

Objective: To assess the prevalence of vitamin B12 deficiency among Iraqi patients with type 2 diabetes mellitus receiving long-term metformin therapy and to identify associated clinical and demographic risk factors.

Methods: This cross-sectional study enrolled 500 type 2 diabetes mellitus patients on metformin for ≥18 months. Serum vitamin B12 levels were measured using chemiluminescence immunoassay. Correlations with demographic and clinical variables (including smoking, hemoglobin, and fasting blood sugar were …

"Paws, Hearts, And Health: Positive Impacts Of Owning A Pet", Sadia Binta Shahid

INRW/Coreq Student Showcase

Fall 2025 Student Showcase

The Parthenon, December 03, 2025, Baylee Parsons, Kaitlyn Fleming, Ashton Pack, Nate Harrah, Caden Adkins, Scott Price, Lilli Ross, Wade Sullivan

The Parthenon

No abstract provided.

Daily Eastern News: December 03, 2025, Eastern Illinois University

Daily Eastern News: 2025-2026

No abstract provided.

Imaging Of Dynamic Processes In Materials With A Laser-Wakefield Accelerator, J. Kang, R. J. Shalloo, M. J. Higgins, S. J.D. Dann, J. N. Gruse, C. I.D. Underwood, A. F. Antoine, C. Arran, C. D. Baird, M. D. Balcazar, N. Bourgeois, J. A. Cardarelli, K. Krushelnick, S. P.D. Mangles, C. D. Murphy, N. Lu, P. P. Rajeev, M. P. Selwood, D. R. Symes, C. P. Ridgers, A. G.R. Thomas, C. Thornton, Z. Najmudin, P. G. Sanders, P. D. Staublin, A. J. Shahani, M. J.V. Streeter

Michigan Tech Publications

Betatron x rays generated from laser-wakefield accelerators are a promising source for imaging dynamic processes in materials. Here, we present proof-of-concept imaging of microstructural evolution in a hypermonotectic Al-Bi alloy, which consists of liquid Bi particles in a solid Al matrix. The images capture the elongation and fragmentation of Bi particles upon isothermal annealing. Because of the femtosecond time scale of the betatron source, the images are not subject to motion blur, whereas the accessibility of the source allows for studies of long-term processes such as annealing. The high-resolution data reveal that the evolution of Bi particles is mediated by …

December 3, 2025 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

2025-12-03 A Hot New Bombshell Has Entered The Seattle Aquarium, Austin Woolley

The Spectator Online

No abstract provided.

Talinghaga At/Ng Pakikibaka: Pagsusuri Sa Mga Pahayag Ng All Up Academic Employees Union - Los Baños, 2019-2020, Cris Lanzaderas, Jennifer Cruz Delfin, Rowell Madula

Dalumat: Multikultural at Multidisiplinaryong E-Journal sa Araling Filipino

Mahalaga sa anomang organisasyong panlipunan ang mabisang pakikipag-ugnayan sa mga pinagsisilbihan nito. Sa kaso ng mga unyon, tungkulin nito ang regular na pakikipagkomunikasyon sa mga miyembro at hindi miyembro nito hinggil sa iba’t ibang usaping may kaugnayan sa sariling kagalingan at kagalingan ng mga kapwa manggagawa. Isa na sa mga paraang ito ang paglalabas ng mga pahayag o statement. Nagagamit din ang pahayag bilang isang kasangkapan sa paglalatag ng tindig at paniniwala ng mga kasapi nito sa isang partikular na isyu. Para sa papel na ito, sinuri ng mga mananaliksik ang dalawampu’t anim (26) na pahayag o statement ng All …

Emerging Tools In Plant Genome Editing, Shilpi Sharma, Naveen Kumar Saroha, Abhilasha Sehrawat, Guiliang Tang, Deepali Singh, Sachin Teotia

Michigan Tech Publications

Plant genome editing has undergone a transformative shift with the advent of advanced molecular tools, offering unprecedented levels of precision, flexibility and efficiency in modifying genetic material. While classical site-directed nucleases such as ZFNs, TALENs and CRISPR-Cas9 have revolutionized genome engineering by enabling targeted mutagenesis and gene knockouts, the landscape is now rapidly evolving with the emergence of novel systems that go beyond the conventional double strand break (DSB)-mediated approaches. Advanced and recent tools include LEAPER, SATI, RESTORE, RESCUE, ARCUT, SPARDA, helicase-based approaches like HACE and Type IV-A CRISPR system, and transposon-based techniques like TATSI and piggyBac. These tools unlock …

The Lumberjack, December 03, 2025

Cal Poly Humboldt's Student Newspaper

The student newspaper of Humboldt State University.

Dopaminergic Regulation Of Aversive Motivation, Elaine M. Grafelman

Dissertations (1934 -)

We all experience adversity in our lives, and we must be able to effectively respond to these challenges in order to thrive. One way to respond to stressors is to change one’s behavior to cope with the stress. This can include escaping or avoiding the stressor, focusing effort to diminish the effect of the stressor, or other coping strategies such as drug use. In fact, stress is one of the principal triggers of relapse for those in the abstinence phase of a substance use disorder and it exacerbates a variety of other disorders. Therefore, it is critical to understand the …

Medical Education Conference 2025, Sultan Qaboos University

Sultan Qaboos University Medical Journal

No abstract provided.

Examining The Impact Of Social Media On The Nutrition Decisions Of College Students And Their Attitudes Toward Nutritional Guidelines, Katlyn Neibaur

Undergraduate Honors Theses

Social media is becoming an increasingly popular platform used by young people to garner information, but this information is not always accurate. Understanding the degree of influence social media has on college students’ dietary habits and attitudes toward nutritional guidelines is vital for improving nutrition literacy efforts and creating policies to protect against nutritional misinformation. This study examined the associations between the social media habits of college students, their attitudes toward nutritional guidelines, and their ability to detect nutritional misinformation. A cross-sectional survey was conducted with 457 undergraduate students at Brigham Young University. The content validity of the survey was …

Strategies For Improving Supported Employment Services For Adults With Intellectual And Developmental Disabilities, Janelle Latoya Bailey

Walden Dissertations and Doctoral Studies

There is a growing need for supported employment services and improved programming among people with intellectual/developmental disabilities (I/DD). The research question for this study was; what are human service staff and administrators’ experiences and perceptions of what is working well in supported employment programs, and how to improve the services offered to adults with I/DD in a northeastern county? The tenets of Kurt Lewin’s change model form the theoretical framework for the study, to serve as a foundation for effective change. A force field analysis approach was used to gather narrative written data from open ended questionnaire responses to grasp …

An Examination Of Psychosocial Factors Related To Male Serial Killers, Rachael Elizabeth Tubbs

Walden Dissertations and Doctoral Studies

Historically, studies on serial murderers have not concentrated in depth on analyzing what psychosocial factors are or how they could influence a man to become a serial killer. The focus of this qualitative study was on the psychosocial characteristics of male serial killers that are from, and based in, the United States. Using a case study analysis approach, the life course of serial killers in the FGCU Radford Database was analyzed to identify themes of adverse childhood experiences such as physical, emotional, or psychological abuse; abandonment by parent or guardian; limited or no social bonds; witnessing abuse; and signs of …

Hidden Threats In Water: The Global Rise Of Emerging Contaminants, Baljit Singh, Abhijnan Bhat, Gayathree Thenuwara, Kamna Ravi, Azza Silotry Naik, Christine O’Connor, Furong Tian

Research Outputs: 2025-Present

The general spread of water safety awareness and enforcement often masks the escalating risks of emerging contaminants (ECs) that evade standard detection and monitoring techniques. Traditional monitoring infrastructures depend heavily on localized laboratory-based testing, which is expensive, time-consuming, and reliant on specialized infrastructure and skilled personnel. While specific types of ECs and detection technologies have been examined in numerous studies, a significant gap remains in compiling and commenting on this information in a concise framework that incorporates global impact and monitoring strategies. We aimed to compile and highlight the impact ECs have on global water safety and how advanced sensor …

Exploring The Potential Of Martian Agriculture: Assessing Viability And Nutritional Composition Of Plants Cultivated In Martian Regolith, Abigail Ross

Honors Theses

In addition to sunlight and water, plants can utilize a small number of nutrients from the soil to biosynthesize all the materials that are needed for growth and development. However, plants require an environment where they are able to obtain those nutrients, such as iron, magnesium, potassium, sulfur, and nitrogen. Environmental factors determine the types and accessibility of nutrients available to plants. Plants then take up these nutrients from the soil to aid in biological mechanisms and the synthesis of important molecules needed for growth and development. Ascorbic acid, commonly known as Vitamin C, is a vital molecule that is …

Spectrum, Volume 55, Issue 11, Sacred Heart University

Newspapers (Obelisk & Spectrum)

Highlights include: SantaCon Shutdown -- The Senior Experience: President’s 63 -- Courageous Dialogue with the Ramos Institute -- Alumni Rediscover SHU with Monthly Tours -- Back-to-Back Conference Champions