Digital Commons Network^™

Sodium Alginate/Aloe Vera/Mangosteen Peel Extraction Hydrogel Composite Films With Anti-Staphylococcal Properties As A Promising Alternative Material In Biomedical Applications, Pruss Chimwai, Poonyarat Apikarnsakulchai, Tirawit Jindaratanaporn, Witsanu Liangaumnuay, Thitima La-Ongthitirat, Purin Somnuake, Pattara Somnuake

Journal of Metals, Materials and Minerals

This study focuses on the development of alternative biodegradable hydrogel films from sodium alginate as a matrix and curing into a hydrogel by CaCl2. Thus, the aloe vera (AV) and the crude extract of mangosteen peels (MPE) were additionally blended. The polymer films were prepared using the casting film process, and their morphology, functional groups, water absorption, antibacterial, thermal, and mechanical properties were characterized using SEM, FTIR, water swelling test, disk diffusion method, DSC-TGA, and UTM. The results demonstrated the heterogeneity between the composites and the polymer matrix, and a lower polarity from the decreased %water swelling from 45% to …

Synergistic Ph-Shift And Heat Treatment For The Recovery Of Protein Isolates From Ham Processing Brine: Evaluation Of Protein Ingredient Quality, Structure, And Functional Properties, Anim Ujong, Carlos Álvarez, Brijesh K. Tiwari, Shay Hannon, Uma Tiwari

Research Outputs: 2025-Present

Ham processing generates significant volumes of brine, a saline wastewater with untapped potential. This study compared three protein recovery methods: direct centrifugation, moderate heat treatment (75 °C), and a combined pH-shift-mild heat (PSMH) approach (65 °C). Both the PSMH method and moderate heat precipitation produced protein concentrates with the highest initial protein contents (62.15%–62.81%), which increased to 91.65%–95.59% purity after desalting, with NaCl levels reduced to <1.5%. Amino acid analysis revealed that PSMH-derived proteins had the highest total amino acid content (96.58 g/100 g). Sodium dodecyl sulphate-polyacrylamide gel electrophoresis confirmed improved recovery of muscle proteins, while Fourier transform infrared spectroscopy indicated that moderate heat treatment reduced the α-helix/β-sheet ratio. Proteins recovered using PSMH exhibited the highest water and fat binding capacities and maintained solubility across a broad pH range. They also exhibited strong foaming ability, although they showed slightly lower foam stability than proteins recovered by other methods, and they demonstrated emulsifying properties that were optimal under mildly alkaline conditions. Overall, PSMH presents a sustainable and efficient strategy for recovering functional proteins from ham brine for use in food and feed applications.

Smart Biosensing Nanomaterials For Alzheimer’S Disease: Advances In Design And Drug Delivery Strategies To Overcome The Blood–Brain Barrier, Manickam Rajkumar, Furong Tian, Bilal Javed, Bhupendra G. Prajapati, Paramasivam Deepak, Koyeli Girigoswami, Natchimuthu Karmegam

Research Outputs: 2025-Present

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder marked by persistent memory impairment and complex molecular and cellular pathological changes in the brain. Current treatments, including acetylcholinesterase inhibitors and memantine, only help with symptoms for a short time and do not stop the disease from getting worse. This is mainly because these drugs do not reach the brain well and are quickly removed from the body. The blood–brain barrier (BBB) restricts the entry of most drugs into the central nervous system; therefore, new methods of drug delivery are needed. Nanotechnology-based drug delivery systems (NTDDS) are widely studied as a potential …

Development Of An Active Crosslinked Nanocomposite Film Based On Gelatin-Ethyl Cellulose, Trans-Cinnamaldehyde, And Silver Nanoparticles For The Preservation Of Sliced Meat, Elham Sarmast, Shiv Shankar, Stephane Salmieri, Sahra Amel Rahmouni, Monique Lacroix

Research Outputs: 2025-Present

This study aimed to develop a novel bioactive biobased packaging film combining gelatin (G) and ethyl cellulose (EC), cardanol and glycerol as plasticizers, trans-cinnamaldehyde (TCA) as a crosslinker/bioactive compound, and silver nanoparticles (AgNPs) as bioactive agents. The degree of crosslinking, mechanical and thermal properties, water solubility (WS), and water vapor permeability (WVP) of the films were analyzed. Molecular interactions within the film matrix were determined by FTIR spectroscopy. The G-EC film, in a 1:2 weight ratio, exhibited improved physicochemical properties compared to the pure G film, with a low WS (7.8%). The incorporation of TCA and AgNPs—to form bioactive nanocomposite …

Eco-Friendly Pva-Walnut Shell-Based Triboelectric Nanogenerator For Biomechanical Energy Harvesting And Self-Powered Touch Sensing, Sabita Tripathy, Gayatri Mohapatra, Arjun Kumar, Manoj Kumar Debnath

Journal of Metals, Materials and Minerals

The growing demand for sustainable power in wearable electronics necessitates eco-friendly energy harvesting alternatives. Herein, a polyvinyl alcohol-walnut shell (PVA-WS) composite was developed as a biodegradable triboelectric active layer for a single-electrode triboelectric nanogenerator (TENG). Walnut shell powder, a lignocellulosic agricultural byproduct, was incorporated into PVA at an optimised 3 wt%, enhancing surface micro-roughness and charge trapping capability as confirmed by SEM and XRD analyses. The fabricated device yielded a peak output voltage of 130 V, short-circuit current of 390 nA, and maximum power of 20 μW at 500 MΩ under 1 Hz excitation, while also successfully harvesting biomechanical energy …

Modernizing Rotc Training: Evaluating The Impact Of Digital Learning On Tactical Performance, Dominick Olhava

Honors Program Theses

Tactical proficiency is a critical component of ROTC officer development, yet current study practices–primarily physical manuals, PowerPoint briefings, and in person instruction–offer limited opportunities for individualized learning, repetition, and long term retention. While digital learning platforms are widely adopted across higher education, they remain underutilized within ROTC programs despite their potential to enhance accessibility, engagement, and performance.

To address this gap, ROTCELERATE (rotcelerate.com) was developed to serve as a comprehensive digital repository designed to centralize and modernize ROTC training materials. The platform consolidates doctrinal references, tactical methodologies, and written study resources, and supplements them with interactive animated visualizations that illustrate …

Play-Based Learning In Private International Preschools In Cairo: Teachers' Perspectives, Kesha L. Stovall

Theses and Dissertations

This thesis explores how play-based learning is practiced and contextualized in private, international preschools in Cairo, Egypt through the perspective of teachers. It calls upon both historical and contemporary theories of play and play pedagogies ranging from the times of Plato and Al-Farabi to the 21st century with Montessori and Dewey. Using a contemporary theory of play presented by Stuart Lester and Wendy Russell as a guiding framework, it examines how play and play-based learning are implemented, shaped and even challenged in a Cairene context. These contexts include sociocultural factors such as parents’ expectations and aspirations, institutional barriers, teacher development …

Slices And Lumps: Division And Aggregation In Law And Life, Lee Anne Fennell

Books

No abstract provided.

Mucin 5ac Modulates Cancer-Associated Fibroblast Heterogeneity Through Epigenetic Reprogramming Of Precursor Cells, Rachel J. Kehrberg, Namita Bhyravbhatla, Zahraa Wajih Alsafwani, Xiaoqi Li, Gopalakrishnan Natarajan, Imran Khan, Randall E. Brand, Maneesh Jain, Surinder K. Batra, Sushil Kumar

Journal Articles: Biochemistry & Molecular Biology

Pancreatic cancer (PC) is characterized by extensive desmoplasia, with heterogeneous cancer-associated fibroblasts (CAFs) as a major component. However, the contribution of distinct precursor cells to CAF heterogeneity remains poorly defined. This study investigated the role of Muc5ac in modulating CAF heterogeneity by maturing precursor cells, including adipose-derived mesenchymal stem cells (AD-MSCs), bone marrow-derived MSCs (BM-MSCs), and pancreatic stellate cells (PSCs), into different CAF subsets. RNA sequencing of precursor cells treated with conditioned media from Muc5ac-proficient or -deficient cancer cells revealed distinct transcriptional profiles. Muc5ac significantly modulated the expression of Dnmts and Tets in AD-MSCs, promoting the acquisition of extracellular matrix …

Prolonged Qt Interval In Hiv-1 Infected Humanized Mice Treated Chronically With Dolutegravir/Tenofovir Disoproxil Fumarate/Emtricitabine, Ali Namvaran, Julian V. Garcia, Mahendran Ramasamy, Kayla Nguyen, Farzaneh Tavakkoli Ghazani, Bryan T. Hackfort, Prasanta Dash, Reagan E. Fisher, Benson J. Edagwa, Santhi Gorantla, Keshoer R. Bidasee

Journal Articles: Cellular & Integrative Physiology

The REPRIEVE Trial recently reported high rates of sudden cardiac death (SCD) middle-aged people living with HIV-1 infection (PWH) using the WHO/NIH-recommended two nucleoside reverse transcriptase inhibitors (NRTIs)/one integrase strand inhibitor (INSTI) regimen to manage HIV-1 viremia. To date, clinically relevant animal models to delineate underlying causes for this remain limited. Here, we assessed if HIV-1-infected NOD.Cg-Prkdc^scidIl2rg^tm1Wjl/SzJ humanized mice (Hu-mice) treated with the WHO/NIH-recommended antiretroviral regimen, dolutegravir (DTG, INSTI)/tenofovir disoproxil fumarate (TDF, NRTIs)/emtricitabine (FTC, NRTIs), can recapitulate abnormalities in the ECG and subclinical structural heart disease that serve as harbingers of SCD in middle-aged PWH. …

Sacred Or Sham? Strengthening Judicial Review Of Religious Sincerity Under The Free Exercise Clause Article Title, Montana Martinez

Faculty Scholarship

While the Court has expanded the scope of Free Exercise protections, it has conspicuously failed to articulate how courts should separate sincere religious claims from fraudulent ones. The result is a doctrinal void: any claimant can recast political or philosophical objections as "religious" and demand constitutional protection. The risk is that the Free Exercise Clause, if stripped of any sincerity filter, will collapse into a generalized right to exemption from law. This Article argues that courts can assess religious sincerity without evaluating the truth or validity of the religious belief, and it proposes a framework grounded in the constitutional text, …

Kim Gyeong-Seok And The Origins Of Northeast Asia’S Corporate Accountability Movement For War And Colonialism, Timothy Webster

Faculty Scholarship

Campaigns to review Japan’s wartime legacy and legal liability have recurred throughout postwar Japan. While most of these efforts have targeted the Japanese government, an important subset of actors has also focused on the role of Japanese corporations. And perhaps no one played a larger role in directing attention towards Japan, Inc. than Kim Gyeong-seok, a Korean forced laborer in the 1940s turned redress activist in the 1990s. As described in this Article, Kim’s 1991 lawsuit against Nihon Kokan launched the corporate accountability piece of the reparations project, an endeavor that continues to create ripples even now. The Article briefly …

Combined Snare And Buddy-Balloon Strategy For Failed Valve Crossing In Valve-In-Valve Transcatheter Aortic Valve Replacement, Hira Sarfraz, Muhammad U. Javed, Parth K. Parikh, Joshua A. Cohen, Raymond L. Benza, Matthew R. Summers, Deepak R. Talreja

Department of Medicine Faculty Publications

Background

Retrograde valve crossing during valve-in-valve transcatheter aortic valve replacement (ViV TAVR) may fail despite modern delivery systems.

Case Summary

A 67-year-old man with a degenerated 27-mm Magna Ease bioprosthesis and unfavorable aortic geometry (kinked ascending aorta at a prior surgical graft site) underwent ViV TAVR, where retrograde valve crossing failed despite multiple stiff guidewires and snare traction alone. Successful delivery of a 29-mm Evolut FX+ was ultimately achieved by combining gooseneck-snare traction for coaxial realignment with a partially inflated Tyshak buddy balloon acting as a mechanical ramp across the surgical valve frame.

Discussion

This case demonstrates a structured, stepwise …

Selenium And Liver Steatosis And Fibrosis: Opposing Direct And Steatosis-Mediated Associations In A Large Cohort, Neda Rehan, Jubilee Benedict, Rehan Qayyum

Department of Medicine Faculty Publications

Background and Aims

Epidemiologic studies have reported conflicting associations between selenium exposure and liver disease. Whether selenium exerts opposing direct and steatosis-mediated effects on liver fibrosis is unknown. To evaluate the associations of blood selenium with elastography-defined hepatic steatosis and fibrosis and to determine whether hepatic steatosis mediates the relationship between selenium and fibrosis.

Methods

We conducted a cross-sectional analysis of adults aged >= 18 years in NHANES 2017-2023. Hepatic steatosis was assessed using the controlled attenuation parameter (CAP) and fibrosis using liver stiffness measurement (LSM). Blood selenium was categorized into quartiles. Survey-weighted multivariable linear regression and structural equation modeling …

Constructing Effectiveness: Culture, Legitimacy, And Strategic Planning In Zoos And Aquariums, Robin Keith

Dissertations

Zoos and aquariums are complex organizations operating with multiple mandates—saving species, providing exceptional care to animals, connecting communities with nature, and inspiring environmental action—making “effectiveness” difficult to define. What counts as success depends on who is asked and which goals are foregrounded. This study investigated how stakeholders in Association of Zoos and Aquariums (AZA)–accredited organizations conceptualize and operationalize effectiveness within strategic planning processes. Prior research on nonprofit and mission-driven organizations has shown effectiveness is multidimensional and often defined differently by various stakeholders. However, little has been known about how these definitions are negotiated through the practice of strategic planning, …

Scholars Called: Ten Years Of Doctorates In Biblical Studies At Asbury Theological Seminary, David B. Schreiner, Jason A. Myers

Academic Books

No abstract provided.

Ash/Isth 2026 Guidelines For Anticoagulant Prophylaxis In Pediatric Patients At Risk Of Venous Thromboembolism, Marisol Betensky, Muayad Azzam, Rachel Bercovitz, Rukhmi V. Bhat, Tina Biss, Brian Branchford, Leonardo R. Brandão, Anthony K.C. Chan, E. Vincent S. Faustino, Qais Hamarsha, Julie Jaffray, Sophie Jones, Hassan Kawtharany, Bryce A. Kerlin, Jana Khawandi, Grace Krider, Nicole Kucine, Riten Kumar, Christoph Male, Paul Monagle, Marie-Claude Pelland-Marcotte, Leslie Raffini, Chittalsinh M. Raulji, Sarah E. Sartain, Clifford M. Takemoto, Cristina Tarango, C. Heleen Van Ommen, Maria C. Velez, Sarak Vesely, John Wiernikowski, Suzan Williams, Hope P. Wilson, Gary Woods, Reem A. Mustafa

Journal Articles: Pediatrics

High-quality data on anticoagulant prophylaxis for pediatric VTE prevention are scarce. Key research priorities include the development and validation of subgroups-specific VTE risk assessment models, and evaluation of the safety and efficacy of risk-stratified anticoagulant prophylaxis strategies across different pediatric subgroups.

BACKGROUND: Venous thromboembolism (VTE) is a significant cause of morbidity in children, particularly among hospitalized patients and those with chronic medical conditions. There is a lack of consensus on anticoagulant prophylaxis strategies.

OBJECTIVE: These evidence-based guidelines from the American Society of Hematology (ASH) and the International Society on Thrombosis and Haemostasis (ISTH) are intended to support patients and health …

« Look The King Is Naked » : Une Étude De The Naked King (2026) D’Alexei Ratmansky Vue À Travers Le Ballet De Cour Du Roi Soleil, Simone Gingerich-Boberg , '26

Senior Theses, Projects, and Awards

No abstract provided.

Quantum Ai And The Future Of Corporate Law, Michael R. Siebecker

Cardozo Law Review

As quantum computing and AI surge toward mainstream adoption, how corporate directors satisfy their duties of care and oversight requires some fiduciary recalibration. The current fiduciary framework that allows directors to escape liability absent “gross negligence” or “utter failure” in oversight may no longer be defensible in a world where advanced analytics offer unprecedented capacity to model, monitor, and foresee significant corporate risks. Behavioral economics makes clear that humans (including corporate managers) remain vulnerable to a variety of biases and heuristics shortcuts in decision making. Technological evolution provides the means to correct such cognitive distortions if boards take an active …

Data Rights For Workers, Pauline Kim, Rachel Leavitt

Scholarship@WashULaw

Workers are subject to immense amounts of data collection on the job, and the algorithmic management tools built with that data can produce negative effects, including deskilling jobs, unstable work hours, reduced wages, and dangerous and degrading working conditions. Workers thus have significant interests how their data are collected and used, and yet they have been excluded from nearly all the recently enacted or proposed data protection laws. Their exclusion stems from data protection’s roots in privacy law and theory, which primarily focused on consumers as data subjects. Current data protection laws, even if expanded to cover workers, would provide …

Taking Legality Seriously: What The Major Questions Doctrine Is — And Isn't, Andrea Scoseria Katz, Ofra Bloch

Scholarship@WashULaw

The Major Questions Doctrine (MQD), a controversial recent innovation of the Roberts Court that applies stricter scrutiny to “major” actions taken by federal agencies, has faced criticism for being atextual, unprincipled, and nakedly ideological. But this critique misses the fact that the doctrine has near-exact analogues in many other legal systems, where it is an established tool for reining in executive overreach. This Article argues that, while the MQD reflects valid rule-of-law concerns, as applied, it lacks theoretical clarity, consistency and limits. More importantly, the Court itself lacks a theory of what the MQD is. We provide an answer grounded …

Privatising International (Organizations) Law, Melissa (M.J.) Durkee

Scholarship@WashULaw

This essay explores the increasing role of private commercial actors within international organizations (IOs) and the implications for international law. Once conceived as state-centred institutions, IOs now routinely involve corporations, trade associations, and philanthropic foundations in lawmaking, policy-setting, financing, and implementation. These actors participate through multiple channels: as observers, delegates, stakeholders, funders, and partners. While private involvement has historical precedents, its contemporary scale and formalization mark a significant transformation in global governance. International law, however, offers little guidance on the boundary between public and private authority, leaving legitimacy concerns unresolved. To evaluate privatization, the article identifies two competing logics: a …

Tariffs And The Progressive Fiscal Constitution, Lawrence J. Liu, Alex Zhang

Scholarship@WashULaw

For more than a century, progressive taxation has constituted the American fiscal state. A resurgent and expanding tariff regime, however, threatens that commitment to progressive distribution. Given the ongoing popularity of tariffs, this Article examines how they might be designed and administered in a way that mitigates their regressive distributive impact. The Article thus develops and assesses proposals to (1) vary tariff burdens in accordance with the consumption of imported goods, (2) reduce income- or payroll-tax burdens on lower-income households, and (3) earmark tariff revenue for specified spending programs. Although none is perfect, we seek to articulate possibilities and highlight …

Effect Of Employees’ Breakfast Choices On Energy Levels In The Hispanic Population Working In Healthcare In South Florida, Jennifer Rivas

Theses and Dissertations

This applied dissertation was designed to examine the effect of employees’ breakfast choices on perceived energy levels among Hispanic healthcare workers in South Florida. As breakfast consumption has been widely associated with cognitive function, productivity, and metabolic stability, this research focused on understanding how specific breakfast patterns influence daily energy in a population that plays a critical role in regional healthcare delivery.

A qualitative survey was developed by the researcher and was used to collect data from Hispanic employees working in a variety of healthcare settings. Participants completed a structured survey assessing breakfast habits, nutritional quality, frequency of consumption, and …

Implementación De Estrategias En La Enseñanza De Los Números Reales A Estudiantes Con Formación Deficiente En Matemática, En Un Instituto Técnico Superior Comunitario De La República Dominicana, Antonio Manuel Rojas Taveras

Theses and Dissertations

Este estudio abordó la problemática del bajo rendimiento en la enseñanza y aprendizaje del conjunto de los números reales en estudiantes de un instituto técnico superior de la República Dominicana que presentaron una formación deficiente en matemáticas. Se observó que los métodos de enseñanza tradicionales, basados en la memorización y la repetición, no son efectivos para abordar las necesidades de estos estudiantes, lo que genera desmotivación y un serio obstáculo para la finalización de sus carreras. Además, factores como el contexto sociocultural, la falta de recursos didácticos, la escasa capacitación docente y los desafíos estructurales del sistema educativo dominicano contribuyeron …

Revisión Sistemática Sobre La Actitud Del Docente De Educación Preescolar Frente A La Incorporación De Niños Especiales Dentro Del Programa Regular Y Sus Efectos En El Aprendizaje De Estudiantes Regulares De Usa, Período 2015 Al 2024, Fressia Mary Medina Greenbaum

Theses and Dissertations

El propósito de esta investigación fue evidenciar hallazgos sobre la actitud del docente de educación preescolar frente a la incorporación de niños especiales dentro del programa regular de educación preescolar y sus efectos en el aprendizaje de estudiantes regulares en preescolares de Estados Unidos de América. La posición que adopte el docente es de suma importancia para el logro de la incorporación de estudiantes especiales desde temprana edad, conocer cuáles son los obstáculos que enfrenta el docente y aclarar cuales son los beneficios tanto para estudiantes especiales como para estudiantes regulares.

La presente investigación utilizó la revisión sistemática como metodología, …

Using Sports Performance Assessment Technologies To Help Narrow Achievement Gaps Of Black Male Adolescent With Other Racial Groups, Patavious R. Sorrell

Theses and Dissertations

This exploratory qualitative collective case study explored how sports performance assessment technologies (SPATs) may support the development of self‑regulatory and motivational processes associated with self‑efficacy among Black male adolescent student‑athletes. Guided by Social Cognitive Theory and the Technology Acceptance Model, the study examined the perceptions of eight coach‑teachers in the Southeastern United States who integrated video analysis, data analytics, goal‑setting and tracking applications, wearable devices and gaming platforms, and reflective communication tools into their coaching practices.

Data were analyzed thematically, revealing three major themes: self‑regulation, self‑mastery assessment, and academic transfer. Findings indicated that SPATs were most effective when used as …

Cultural Heritage Curriculum And Student Identity Development: A Mixed-Methods Study, Alexus Corley

Theses and Dissertations

This applied dissertation was designed to examine the influence of a cultural heritage curriculum on first-grade students’ cultural knowledge, awareness, and understandings of culture. Specifically, the study investigated the extent to which participation in a 4-week cultural heritage curriculum influenced students’ knowledge of cultural history and contemporary contributors, their understandings and perspectives about culture, and the convergence of quantitative and qualitative findings.

Using a qualitative-dominant mixed-methods research design, the study was conducted with 19 first-grade students enrolled in a Title I elementary school in Central Florida. Quantitative data were collected using the researcher-developed cultural knowledge preintervention and postintervention assessment and …

Property Rights V. Taxpayer Rights: The Battle Over Tax Foreclosures, Stewart E. Sterk

Articles

No abstract provided.

Pharmaceutical Mergers: Do We Have The Right Cure?, Robin Feldman, Gideon Schor, Yaniv Konchitchki, Tanziuzzaman Sakib

Faculty Scholarship

Few federal agencies wield tools more powerful than the Federal Trade Commission’s authority to review—and deny—proposed mergers between companies. This authority is powerful for a reason: Large mergers can be uniquely harmful to the United States economy, potentially reducing competition, undercutting consumer choice, and inflating prices.

The pharmaceutical industry is particularly sensitive to merger harms, given the limited number of competitors and the inelasticity of demand for prescription drugs. As a result, when pharmaceutical companies seek to merge, the FTC often requires that one of the companies divest ownership of certain drugs not yet on the market—so-called “pipeline” drugs––to a …