Digital Commons Network^™

Tmem116 Crispr-Mediated Knockout Prevents Proper Lens Regeneration In Iberian-Ribbed Newts, Damien T. Mann

Honors Theses and Capstones

Eye diseases like cataracts, age-related macular degeneration (AMD), and glaucoma are widespread and detrimental conditions affecting many people across the globe. While there are reliable and successful treatments for those with cataracts that can reverse vision impediments, others like glaucoma and AMD have limited treatment options. Additionally, eye damage resulting from these conditions is commonly irreversible, establishing a need for new treatment options. The Iberian-ribbed newt, Pleurodeles waltl, is a salamander species primarily studied for their amazing regenerative capabilities. Particularly, these newts are capable of de novo lens regeneration after a complete resection, providing a unique opportunity to study regeneration …

Faith, Formation, And Formalization: Entrepreneurship Development Among Women In Ghana, Patricia Adams-Williams

Doctor of Ministry

The problem addressed in this study is the absence of a unified, faith-centered framework that equips single mothers in Ghana to build sustainable livelihoods while strengthening their spiritual identity. Although Ghanaian women demonstrate remarkable resilience and entrepreneurial drive, many remain confined to informal markets without access to business training, mentorship, or systems that connect their work to their calling. This dissertation argues that integrating spiritual formation with entrepreneurship training creates a pathway for lasting transformation. The thesis of this study is that Kingdom-centered entrepreneurship, rooted in biblical identity and supported by communal mentorship, empowers women to move from survival to …

Anuran Occupancy Of Created Wetlands Within Reforested Legacy Surface Mines In Kentucky And West Virginia, Jillian C. Newman, Steve Price, Jacquelyn C. Guzy, Joshua Castle, John J. Cox, Jeffery L. Larkin, Christopher D. Barton

Forestry and Natural Resources Faculty Publications

Restoration of habitat is an important component of wildlife management. Surface coal mining has altered forest cover in the Central Appalachians, and most reclamation activities on previously mined lands result in non-native grasslands or shrub lands. The Forestry Reclamation Approach (FRA), which emphasizes non-native vegetation removal, soil decompaction, planting of native trees and shrubs, and, in some cases, wetland creation represents an alternative to grassland-based reclamation that may promote forest-associated wildlife on legacy surface mines. We used automated recording units to evaluate the response of anurans to created wetlands and the FRA in Kentucky and West Virginia, USA. We used …

Male Disposability, Law, And Feminism, Edward Cantu

Faculty Works

This article explores scientific evidence that societies care more about the welfare and safety of females than that of males, and that this dynamic of "male disposability" is deeply entrenched in culture, and thus in law. The recognition and integration of male disposability theory would mean an evolutionary leap in modern theorizing about gender and the law, but it is ignored. Why? Feminist theory dominates current academic gender discourse. Far from appreciating the explanatory power of male disposability theory, feminist theorists are often invested in theorizing gendered problems in ways that mischannel compassion away from men and toward women. The …

The Federal Rules Of Evi-Dance: Exploring And Reimagining Evidence Law Through Music, And Proposing Amendments To Rule 604, Brian C. Potts

Suffolk Journal of Trial and Appellate Advocacy

No abstract provided.

Microglial Apoe Across Alzheimer’S Disease-Relevant Pathologies, Georgia Nolt

Theses and Dissertations--Physiology

APOE exists as three common alleles (APOE2, APOE3, APOE4) that encode their corresponding protein isoforms (apoE2, apoE3, apoE4). Despite differing by only one or two single-amino acid substitutions, each APOE allele confers a distinct AD risk profile with APOE4 increasing risk by 28% and APOE2 decreasing risk by 14% compared to the most commonly expressed APOE3 allele. While traditionally considered “neutral,” APOE3 still accounts for ~36% of AD cases while APOE4 contributes ~57%, indicating that the majority of AD cases would not occur in the absence of the APOE3 and APOE4 alleles. Microglia, the resident phagocytic immune cells …

Investigating Sex Differences In The Regulation Of Conditioned Morphine Reward By Orexin, Farzana Akter Koly

Psychology Theses

Strong activation of the brain’s reward circuitry by morphine and morphine-associated cues drives the progression toward morphine abuse. Additionally, orexin neurons in the lateral hypothalamus (LH) are activated in response to cues paired with morphine reward. The orexin system, particularly the orexin-1 receptor (OX1R) regulates reward-seeking behavior through its activation. Despite the well-established role of orexins in reward-related behaviors, the specific contribution of OX1R in morphine-associated reward remains unclear. Furthermore, while sex differences in drug reward and reward-related behaviors are well documented, they remain unexplored in the regulation of morphine-associated reward by orexins. To address this gap, the present study …

Characterizing Gut Microbial Communities And Symbiont-Mediated Detoxification In Herbivorous Insects, Rachel C. Vargas

Biology Dissertations

Insect gut bacteria are vital contributors to host physiology, yet the broader prevalence and fitness implications of symbiont-mediated detoxification remain poorly understood. This thesis investigates these dynamics across three research chapters. Chapter 1 uses 16S rRNA sequencing to characterize how grasshopper gut microbial communities vary across species, dietary breadths, and gastrointestinal segments. Chapter 2 evaluates the detoxification capacity of over 150 bacterial isolates from diverse herbivores against the plant allelochemicals phenethyl isothiocyanate, rutin, and chlorogenic acid to determine if host dietary specialization predicts microbial metabolic ability. Finally, Chapter 3 employs fitness bioassays to test whether inoculating generalist herbivores with detoxifying …

American Elderberry's Next Top Pollinator: Evaluating The Role Of Arthropods In Pollination, Jenny K. Burrow

Graduate Theses/Dissertations

American elderberry (Sambucus nigra subsp. canadensis) is a woody deciduous shrub native to eastern North America. In addition to its long history of use by indigenous peoples, there is renewed interest in cultivating and consuming American elderberry, primarily driven by expanding health supplement markets. Despite recent advances in horticultural development of American elderberry, its pollination ecology remains poorly understood. In this field study, I evaluated the contribution of arthropod visitors to pollination of American elderberry. To do this, I first characterized the identities and abundances of arthropod visitors via timed arthropod collections and floral observations during peak flowering …

2026 Oer Deep Dive, Caterina B. Azzarello, Cassendra Bergstrom, Kirsten Gilderhus

About OER

The Affordable & Open Educational Resources (AOER) Committee at UNC, in collaboration with the Colorado Department of Higher Education, UNC’s Center for the Enhancement of Teaching and Learning, and the University Libraries, hosted an in-person OER Deep Dive professional development workshop on Tuesday, May 19, 2026. This full-day event was created for faculty and staff interested in learning more about Open Educational Resources (OER) and exploring ways to incorporate them into their instructional practices.

Throughout the workshop, participants examined the foundations of OER, discussed distinctions between openly licensed and freely available materials, and explored the role of affordable course content …

A Transdisciplinary Approach To Advancing Water Security And Public Health: The “Nurse + Engineer” Model For Achieving Sustainability In Wash Systems Using Community-Based Participatory Research, Daniel B. Oerther, Sarah Oerther

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Human health is linked to the health of the environment, a concept referred to as planetary health. As environmental challenges become increasingly complex, single-disciplinary approaches are insufficient to achieve sustainable solutions. This article presents a transdisciplinary framework, termed the "Nurse + Engineer" model, as a novel methodology for addressing complex problems at the nexus of environmental engineering and public health. The model integrates the technical design and systems-level thinking of environmental engineering with the community-based, patient-centered care of nursing. This work details the key lessons learned from the retrospective application of this framework to a series of multi-year, community-based participatory …

Environmental Engineers Develop Solutions To Problems Of Planetary Health: The Legacy Of Professor P. Aarne Vesilind, Daniel B. Oerther

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

The principal ethical obligation of the engineering profession, to "hold paramount the health, safety, and welfare of the public," has been challenged for decades. Professor P. Aarne Vesilind identified two primary deficiencies: an anthropocentric bias that values nature only instrumentally and the use of non-mandatory, aspirational language for environmental protection, which resulted in the exclusion of enforceable environmental canons. This paper argues that two recent developments provide a comprehensive response to Vesilind's recommendations for engineering ethics. First, the United States Bureau of Labor Statistics has redefined environmental engineering as "developing solutions to problems of planetary health." Second, Oerther proposed a …

Examining The Drivers, Consequences, And Depoliticization Strategies Of Greenhouse Gas Emission Polarization Among The American Public, Lauren Wilner

Environmental Studies Honors Theses

This thesis examines the politicization of greenhouse gas emissions within the American public, tracing its evolution from a consensus based scientific topic to a deeply polarized partisan issue. While early research established a clear link between greenhouse gases and global warming, the late 20th century saw a strategic rise in skepticism fueled by conservative think tanks, contrarian scientists, and industrial interests. This study analyzes the psychological mechanisms and media practices that have exacerbated this divide and decline in public environmental concern, which has resulted in negative social and environmental effects due to a slowed federal response to the climate crisis. …

Comprehending Levels Of Explainability And Ai Recommendations (Clear) Study Series, Virginia Sullivan

Dissertations

AI systems can offer a great deal to improve decision-making through efficiency and predictive accuracy due to their unique ability to rapidly analyze large amounts of data relevant to the decision. Yet many AI systems remain opaque, limiting users’ ability to evaluate outputs and leading to issues of mistrust or over-reliance. This dissertation investigates how varying levels of AI explainability affect trust, perceived reliability, understanding, and confidence, and identifies perceptual and behavioral indicators of over-reliance behavior in AI-assisted decision making scenarios. This dissertation is organized as a three-study series. The CLEAR survey study uses a mixed design to examine the …

Icipe Annual Report 2025, International Centre Of Insect Physiology And Ecology (Icipe)

icipe Annual Reports

No abstract provided.

Optimized Nano-Bilosomes Loaded Ocular Insert As A Promising Approach For Boosting Voriconazole Ocular Bioavailability: In-Vitro, Microbiological, And In-Vivo Assessments, Eman Gomaa, Eman Gomaa

Nanotechnology Research Centre

The eye possesses numerous physiological barriers that significantly limit the absorption of administered drugs, as only < 5 % get through. These barriers restrict drug bioavailability, often necessitating multiple dosing, which can lead to poor patient compliance. The study goal is to efficiently incorporate Voriconazole (VRC), a widespectrum antifungal candidate with a short half-life, into stable, biocompatible, non-irritating bile salt nanoparticles (Bilosomes, BLOs) to enhance its ocular delivery. Bilosomes were prepared by the ethanol injection method. Experimental (33 ) Box–Behnken Design (BBD) was employed; the amount of bile salt, cholesterol, and span-60 were chosen as independent variables, while entrapment efficiency (EE%), cumulative VRC release (Q8h), particle size (PS), zeta potential (ZP), and polydispersity index (PDI) were the dependent variables. The formula of optimization showed EE% (59.04 ± 1.88 %), cumulative release after 8 h (81.35 ± 0.69 %), PS (222.53 ± 2.04 nm), ZP (− 72.53 ± 1.75 mV), and PDI (0.225 ± 0.03). It was chemically characterized using DSC and FTIR. Its spherical arrangement was confirmed using TEM. For ophthalmic application, the optimized formula was included in ocular inserts to extend ocular residence time while minimizing dosing frequency. The optimal VRC-loaded bilosomal ocular insert met the acceptable physicochemical criteria, was sterilized using UV radiation for conducting microbiological assay, in-vivo study, and pharmacokinetic analysis. For safety evaluation, an eye irritation study and histopathological examination were conducted. The results confirmed its effectiveness as evidenced by a significantly larger inhibition zone and 8.39-fold enhancement in VRC bioavailability compared to its suspension. These findings support the potential of bilosomes-loaded ocular insert as an effective ocular delivery of VRC.

Off-Label Abuse: The Prosecution Of Individuals For Pesticide Crimes Under The Federal Insecticide, Fungicide, And Rodenticide Act, Joshua Ozymy, Melissa Jarrell Ozymy

Natural Resources Journal

When individuals commit pesticide crimes involving significant harm or culpable conduct, they may be prosecuted for criminal violations of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), but we have little knowledge of how individual offenders have been prosecuted historically for such crimes. Using content analysis of 2,728 environmental crime prosecutions resulting from U.S. EPA criminal investigations, 1983 to 2021, we select all cases of individuals prosecuted under FIFRA for our analysis. We find that 100 cases were adjudicated, resulting in 135 years of probation, 75 years of incarceration, and $4.2 million in monetary penalties assessed at sentencing. Of those …

An Anti-Adhesive Compound Modulating The Production Of Staphylococcus Aureus Cell Wall-Anchored Proteins, Allison C. Leonard, Ruina Bao, Cindy Menjivar, Megan J. Myers, Telmo O. Paiva, Zhiyong Zheng, Kirsten A. Berry, Kenneth W. Bayles, Ronald S. Flannagan, Yves F. Dufrêne, Jeffrey L. Bose, David E. Heinrichs, Georgina Cox

Journal Articles: Pathology and Microbiology

As one of the leading global causes of death associated with antimicrobial resistance, Staphylococcus aureus frequently colonizes the human nasal cavity and adheres to keratinized skin, establishing reservoirs that drive subsequent infections and emphasize the need for new decolonization strategies. Using a high-throughput, whole-cell screening platform, here we identify geranylgeranoic acid (GGA), a naturally occurring polyunsaturated, branched-chain fatty acid, as having dual activity against methicillin-resistant S. aureus (MRSA). At elevated concentrations, GGA exhibits microbicidal effects, whereas at sub‑microbicidal doses, it effectively inhibits MRSA adhesion to keratin, fibronectin, fibrinogen, and immunoglobulins. GGA possesses anti-adhesive activity against a panel of multidrug-resistant S. …

Ai, Experimental-Based Discovery And Preclinical Ind-Enabling Studies Of Selective Bmx Kinase Inhibitors For Development Of Cancer Therapeutics, Rwan Wael Elsanhoury

Selected Full-Text Dissertations 2020-

The current work aims to design and provide a preliminary IND-enabling study of selective BMX inhibitors for cancer therapeutics development. BMX is an emerging target, more notably in oncological and immunological diseases. In this work, we have employed a predictive AI-based platform to design the selective inhibitors considering the novelty, IP prior protection, and drug-likeness properties. Furthermore, selected top candidates from the initial iteration of the design were synthesized and chemically characterized utilizing 1H NMR and LC-MS. Employing a panel of biochemical (enzymatic) and cancer cell lines, the selected molecules were tested against these assays. In addition, we used artificial …

Development Of A Semi-Mechanistic Pharmacokinetic-Pharmacodynamic Model For Beta-Lactam Antibiotic Combination Against Enterococcus Faecalis Based On Time-Kill Assays To Predict Drug Disposition And Guide Dosing Strategy In A Severe Renal Impairment Population, Ruhma Zia Khan

Selected Full-Text Dissertations 2020-

Bacterial resistance to antibiotics continues to be a global health problem, limiting antibacterial therapy against infective endocarditis caused by Enterococcus faecalis. To overcome increasing resistance, dual beta-lactam therapy has been advocated as an alternative regimen for treatment – the synergistic activity against E. faecalis demonstrated to be effective. Currently, ampicillin plus ceftriaxone is the standard of care, but the practical application of this therapy is limited by ampicillin’s poor stability in solution at room temperature. A synergistic combination of penicillin plus ceftriaxone shows promise due to penicillin’s superior stability at ambient temperature, but ceftriaxone’s potential to cause hepatoxicity further limits …

Factors Affecting Detection Of A Cryptic Ambush Predator Using Camera Traps, With Implications For Snake Monitoring, Sarah Elizabeth Ebert

Theses, Dissertations and Capstones

Camera traps are becoming increasingly popular in wildlife research because they can be deployed for long time periods with little maintenance and are much less invasive than traditional trapping methods. However, they are primarily used to study large mammals and have not been extensively tested for snake species, many of which are cryptic and understudied. The Adapted-Hunt Drift Fence Technique (AHDriFT) arrays were designed to improve detection of herpetofauna by attaching camera traps to drift fences. In the summer of 2022, we installed 20 AHDriFT arrays at the Marine Corps Recruit Depot Parris Island in coastal South Carolina where we …

Prescriptive Behaviors: Tracking The Social Impact Of Film Portrayals Of Black Men, Garfield Ronald Benjamin

Theses and Dissertations

Cinematic and televisual media express the thoughts and emotions of people and cultures with the potential of unifying people through the social realities that are created around the visuals, narratives, and on-screen interpersonal interactions. Through media like film, television, and short-form online video, people interact with others in ways that, because of barriers like physical distance and/or social structures, they may not be able to in real life. The images, sounds, and stories depict their own realities, which are consumed, interpreted, and understood by viewers and can inform their perceptions and interpersonal interactions. Stuart Hall, Jamaican-British, cultural theorist, and political …

Climate, Energy, Economy: Interconnected Perspectives From Politics, Business, And The Public, Isabella Harper Heinzen

Theses and Dissertations

When considering the economic and social costs and benefits of a global, intergenerational, and environmental issue, rigid analysis often falls short. The topics discussed in this thesis aim to address the complex moral, economic, and political concerns regarding climate change to provide a holistic view of the issue and the role humans play. The first section on the scientific consensus addresses concerns regarding the existence and severity of climate change, finding where the responsibility lies for humans. The second section analyzes the energy context in modern society to understand the call for a transition from oil and gas to renewable …

Applying Groupthink To Digital Spaces: The Rise Of Online Conspiracy Theory Networks, Lily Karen Schow

Theses and Dissertations

This thesis examines the transformation of political paranoia and collective decision-making in the United States from the twentieth century to the digital age. Building on Richard Hofstadter’s concept of the “paranoid style” and Irving Janis’s theory of groupthink, it argues that the dynamics of conspiratorial thinking and collective misjudgment have not disappeared but have been reconfigured by digital communication systems. While Hofstadter identified paranoia as a recurring rhetorical mode and Janis analyzed groupthink as a pathology of small, cohesive decision-making groups, this study contends that both frameworks require adaptation to account for contemporary digital environments. The analysis traces how historical …

The Heretical Church: A Comparative Analysis Between The Gospel Of Thomas And The Gospel Of John, Isabella R. Moore

Theses and Dissertations

This thesis uses a comparative analysis between the allegedly “heretical” Gospel of Thomas and its canonical counterpart, the Gospel of John, to conduct a critique of the contemporary Catholic Church. This analysis and critique also utilize evaluations of medieval and modern definitions of heresy within a religious context, as well as a comparison between bishop dissent of these “secret” or “gnostic” gospels in the 3rd, 4th, and 5th centuries and papal dissent in the 21st century. After conducting the comparative analysis between the two gospels, I posit that the Church’s charge of heresy toward the Gospel of Thomas is an …

Human Being And Being Human In Frankenstein Through The Lens Of Catholic Social Teaching, Faria S. Sookdeo

Theses and Dissertations

This dissertation argues that looking at social issues, such as racism, adverse effects of advancement in and use of science and technology, and environmental concerns, in Mary Shelley’s Frankenstein through a Catholic Social Teaching (CST) lens enables an understanding of the nature of humans that brings marginalized and non-marginalized creatures, both human and non-human in a common community and emphasizes and that our behaviors towards such creations are what define our humanity and are vital to the preservation of our environment, subjects that are as relevant today as they were when Shelley first published Frankenstein in 1818 and when the …

Using High Speed Kinematics To Investigate Kinematic Variation Across Populations Of Astyanax Mexicanus, Agniva Sinha

Theses and Dissertations

Kinematic analysis pipelines now provide temporal and geometric resolution for determining a variety of body movement. These machine-learning trained programs allow behavioral neuroscientists to dissect complex behaviors and relate changes in those movements to conserved neural assemblages. These analyses are common in model organisms, but a lack of ethologically driven kinematic work in non-models has hampered our understanding of how evolution shapes behavior through sensorimotor circuits. Astyanax Mexicanus is a unique model organism that allows us to understand how evolutionary divergence as a result of adaptation to environmental conditions leads to genotypic and associated phenotypic changes in brain development and …

The Impact Of Music Education On Language Acquisition Of English Language Learners, Andrew David Frey-Gould

Theses and Dissertations

Schools continue to face increasing accountability pressures to improve English language proficiency outcomes for English Language Learners (ELLs), while access to arts education, particularly music, has declined in many districts. This study examines whether music education can serve as an effective and equitable support for language development among elementary ELL students. The purpose of this causal-comparative study was to determine whether participation in ensemble-based music programs (i.e., band, orchestra, and chorus) is associated with greater gains in English language proficiency than participation in compulsory general music instruction. This study is grounded in Krashen’s Second Language Acquisition theory and Patel’s resource-sharing …

Prevention Of Inflammation-Associated Neurodegeneration: Assessing The Efficacy Of N,N-Dimethylacetamide (Dma) In Lipopolysaccharide (Lps)-Induced Neuroinflammation Using C57bl/6 Mice, Teeshavi Devi Acosta

Theses and Dissertations

Neurological function is closely linked to both longevity and quality of life. While some degree of neurodegeneration occurs naturally with aging, pathological neurodegeneration leads to devastating functional decline. The mechanisms underlying these processes remain incompletely understood; however, neuroinflammation is recognized as a key driver of neuronal dysfunction and death. Emerging evidence indicates that neuroinflammatory cascades can precede and potentiate hallmark features of neurodegenerative diseases, including synaptic loss and cognitive decline observed in Alzheimer’s disease (AD). Activation of the NF-κB signaling pathway contributes to amyloid beta (Aβ) peptide production, further amplifying a cycle of inflammation and neuronal injury. Preclinical work from …

2026-2027 Catalog, Governors State University

Catalogs

The 2026-2027 Governors State University Undergraduate and Graduate Catalog is a comprehensive listing of current information regarding:
Degree Requirements
Course Offerings
Undergraduate and Graduate Rules and Regulations