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Mitochondria As Primary Cause Of Neurodegeneration: Evaluating Causality Across Amyotrophic Lateral Sclerosis (Als), Alzheimer's, And Parkinson’S Diseases, Makenzie G. Johnson Jan 2026

Mitochondria As Primary Cause Of Neurodegeneration: Evaluating Causality Across Amyotrophic Lateral Sclerosis (Als), Alzheimer's, And Parkinson’S Diseases, Makenzie G. Johnson

Undergraduate Honors Theses

Neurodegenerative diseases like Alzheimer's Disease (AD), Parkinson’s Disease (PD) and Amyotrophic Lateral Sclerosis (ALS) have historically been explained through alternate hypotheses despite shared clinical hallmarks that lead to neuron loss. However, these varying explanations could not account for how disease onset begins among other individual issues. This thesis aims to show that mitochondrial dysfunction is a primary driver of neurodegeneration as well as a unifying mechanism shared between the three diseases. Evidence presented in this thesis will show that many issues can arise in mitochondria including issues with energy production, mitochondrial DNA (mtDNA), apoptosis activation, and calcium regulation. These issues …

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Dental Implantology: A Literature Review, Kylie Taylor Jan 2026

Dental Implantology: A Literature Review, Kylie Taylor

Undergraduate Honors Theses

Dental implant therapy is the process of replacing teeth as a form of treatment to improve quality of life, function, and esthetics. The success of the implant depends on the surgical technique, type of prosthetic, and factors related to individual patients. The most important factor for implant success is osseointegration. Osseointegration is a process in which success is determined by the bone quality, the surface characteristics of the implant and the surgical approach. Some approaches to improve the osseointegration of the implant are low-speed drilling, guided surgery, and reduced surgical trauma at the site. The impact of systemic conditions, health …

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Dose-Dependent Developmental Toxicity Of Cisplatin In Zebrafish Embryos, Reagan D. Sellers, Katherine T. Doucet, Jinhee Park, Andrea Florian Jan 2026

Dose-Dependent Developmental Toxicity Of Cisplatin In Zebrafish Embryos, Reagan D. Sellers, Katherine T. Doucet, Jinhee Park, Andrea Florian

SPARK Symposium Presentations

Cisplatin is a widely used chemotherapy drug for treating various types of cancer. Although cisplatin is effective in killing cancer, it can also cause toxic side effects in normal tissues. Because cisplatin can cross the placental barrier, its use during pregnancy is generally avoided, particularly during early embryonic stages of fetal development. Exposure to cytotoxic drugs during embryogenesis may lead to developmental abnormalities, birth defects, or pregnancy complications. Understanding how cisplatin affects early development is therefore important.          
       Zebrafish (Danio rerio) are an established model for studying developmental toxicity due to their rapid external development, transparent embryos, and genetic similarity to …

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Annual Reports Of The Selectmen, Tax Collector, Town Clerk, Trustees Of The Cemetery, Trustees Of The Public Library, Trustees Of The Trust Funds And Treasurer For The Year Ending December 31, 2025, Board Of Education And School Treasurer For The Year Ending June 30, 2025, Together With The Statistics Of The Town Of East Kingston, New Hampshire 2025, East Kingston Town Representatives Jan 2026

Annual Reports Of The Selectmen, Tax Collector, Town Clerk, Trustees Of The Cemetery, Trustees Of The Public Library, Trustees Of The Trust Funds And Treasurer For The Year Ending December 31, 2025, Board Of Education And School Treasurer For The Year Ending June 30, 2025, Together With The Statistics Of The Town Of East Kingston, New Hampshire 2025, East Kingston Town Representatives

East Kingston, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

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Annual Report For The Town Of Bridgewater, New Hampshire For The Fiscal Year Ending December 31, 2025, Bridgewater Town Representatives Jan 2026

Annual Report For The Town Of Bridgewater, New Hampshire For The Fiscal Year Ending December 31, 2025, Bridgewater Town Representatives

Bridgewater, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

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Kingston New Hampshire Town Report 2025, Kingston Town Representatives Jan 2026

Kingston New Hampshire Town Report 2025, Kingston Town Representatives

Kingston, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

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Fisheries Research Report No. 359: Metropolitan Monitoring Program 2025, Alissa Tate, Claire B. Smallwood, Karina L. Ryan, Troy Matthews Jan 2026

Fisheries Research Report No. 359: Metropolitan Monitoring Program 2025, Alissa Tate, Claire B. Smallwood, Karina L. Ryan, Troy Matthews

Fisheries Research Reports

Ongoing monitoring of recreational fisheries in the Perth Metropolitan zone is essential to ensure the sustainable use of fisheries resources. Surveys of shore- and boatbased recreational fishers within the Metropolitan zone of the West Coast bioregion provide information on human dimensions and catch-per-fisher as well as mean length and weight of key recreationally caught species. For shore-based fishers, estimates of fishing effort, catch and harvest are also presented for key nearshore species. This information is used to support ongoing assessments for key nearshore species and the development and evaluation of harvest strategies and other management actions, such as for Australian …

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Police Reform As System Justification, Shawn E. Fields Jan 2026

Police Reform As System Justification, Shawn E. Fields

Journal of Criminal Law and Criminology

System Justification Theory (SJT) provides a useful lens through which to critique recent police reform efforts. SJT posits that members of society tend to justify and maintain existing social and political systems even when those systems disadvantage them, because the predictability of the status quo provides palliative, epistemic, and existential comfort in what otherwise appears to be an unjust and inequitable societal structure. Contrary to “false consciousness” theories, SJT claims that disadvantaged groups may intentionally rationalize what they know to be an unfair status quo, because doing so reduces social anxiety and threat while providing much desired order and meaning …

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Synthetic Contact Zones: Meeting Nature And Animals In Video Games, Sarah C. Mcpherson Jan 2026

Synthetic Contact Zones: Meeting Nature And Animals In Video Games, Sarah C. Mcpherson

English Theses

Due to economic and environmental barriers, encounters with animals and nature have become increasingly inaccessible for many people, while video games have emerged as a common site for simulated environmental interaction. This thesis conceptualizes video games as synthetic contact zones, or digital spaces where representations of humans, animals, and environments interact, conflict, and shape one another. Drawing on the theories of Mary Louise Pratt, Donna Haraway, and Alenda Y. Chang, this project analyzes how video games model relationships between players, animals, and ecological systems through interactive mechanics and environmental storytelling. Explorations of Red Dead Redemption 2, Blair Witch, …

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Hostos Community College Academic Bulletin 2025-2026, Hostos Community College Jan 2026

Hostos Community College Academic Bulletin 2025-2026, Hostos Community College

College Bulletins

This is the official college catalog for 2025-2026. It contains course descriptions as well as information on degree programs, college resources and services, financial aid, admissions, and the academic calendar.

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How Gender Differences Influence The Presentation, Diagnosis, And Lived Experience Of Females With Autism Spectrum Disorder, Casey A. Vanyo Jan 2026

How Gender Differences Influence The Presentation, Diagnosis, And Lived Experience Of Females With Autism Spectrum Disorder, Casey A. Vanyo

All Electronic Theses and Dissertations

Autism spectrum disorder (ASD) is a neurodevelopmental condition with a highly variable presentation influenced by gender. Historically, autism research has focused primarily on males, contributing to the under recognition and misdiagnosis of girls, women, and gender-diverse individuals. Women engage in camouflaging behaviors to align with social expectations, which can mask autistic traits and contribute to higher levels of anxiety, depression, and emotional exhaustion. This thesis examines how gender shapes the presentation, diagnosis, and lived experiences of autistic females. It explores differences in diagnostic practices, mental health outcomes, and access to support. Findings suggest that current frameworks often fail to capture …

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Excess Nitric Oxide Alters Cellular Ph To Restrict Salicylic Acid Movement And Systemic Immunity, Fan Xia, Huazhen Liu, Keshun Yu, Xinyu Yuan, Aardra Kachroo, Pradeep Kachroo Jan 2026

Excess Nitric Oxide Alters Cellular Ph To Restrict Salicylic Acid Movement And Systemic Immunity, Fan Xia, Huazhen Liu, Keshun Yu, Xinyu Yuan, Aardra Kachroo, Pradeep Kachroo

Plant Pathology Faculty Publications

Plants carrying a mutation in S-nitrosoglutathione reductase 1 (GSNOR1) accumulate high nitric oxide (NO) and exhibit impaired immunity characterized by reduced pathogen-responsive salicylic acid (SA) accumulation and failure to activate normal SA signaling. We show that this reduced SA responsiveness in gsnor1 plants arises from impaired vascular-associated movement of SA, thereby compromising systemic acquired resistance (SAR). Elevated NO perturbs cellular pH homeostasis, acidifying the apoplast and alkalinizing the cytosol, which likely interferes with phloem-associated SA movement and renders gsnor1 plants unresponsive to foliar SA. In contrast, SA supplied via root drench restores SA signaling and SAR in gsnor1, …

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Statins For Primary Prevention Of Variceal Bleeding In Cirrhosis: A Scoping Review, Jason Brumitt Jan 2026

Statins For Primary Prevention Of Variceal Bleeding In Cirrhosis: A Scoping Review, Jason Brumitt

Faculty Publications - College of Physical Therapy

Background/Objectives: Variceal bleeding (VB) is a major complication of cirrhosis, marking a progression from a compensated to a decompensated stage of the disease. Previous research has suggested that HMG-CoA reductase inhibitors, commonly called statins, may have therapeutic benefits for those living with cirrhosis, though their exact benefits and role have yet to be elucidated. This scoping review evaluates the potential role of statins in the primary prevention of variceal bleeding in patients with cirrhosis, and if there exists a difference between hydrophilic and lipophilic statins for this indication. Methods: Publications from the last 10 years with primary or secondary outcomes …

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The Unmaking Of Section Two, Maureen Edobor Jan 2026

The Unmaking Of Section Two, Maureen Edobor

Scholarly Articles

Section 2 of the Voting Rights Act now stands at a paradoxical crossroads. Though it remains the statute’s central protection against racial vote dilution after Shelby County v. Holder, it is increasingly undermined by a constitutional framework that treats race-conscious remedies as suspect rather than necessary under Section 2. This Essay argues that Section 2 is being quietly unmade—not through direct invalidation, but through the convergence of Equal Protection Doctrine, racial-gerrymandering jurisprudence, and an ascendant commitment to colorblind constitutionalism. Tracing the Fifteenth Amendment’s original design and Congress’s expansive enforcement authority, the Essay situates Section 2 within a constitutional tradition …

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Should The Illiberal Arts Be Servile In A Classical Christian Education, Nadine B. Kong Mrs. Jan 2026

Should The Illiberal Arts Be Servile In A Classical Christian Education, Nadine B. Kong Mrs.

Master of Arts in Classical Studies

The purpose of this thesis is to research the role and position of the illiberal arts in a classical Christian education (CCE).  The current climate of growth for CCE makes it a fitting moment to consider what bearing the illiberal arts should have on paideia formation.  To answer this question, the historical context of CCE and the illiberal arts is presented.  This leads to a complex issue around the various imprecise terms and historical attitudes surrounding the illiberal arts.  Some synonymous terms have demeaning connotations: ‘servile arts’ or ‘illiberal arts,’ and others less negative, such as ‘common arts’ or ‘mechanical …

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Awakening The Mind: How Secure Attachment Impacts Language Acquisition In Charles Dickens's Literary Orphans, Alaina Gray Jan 2026

Awakening The Mind: How Secure Attachment Impacts Language Acquisition In Charles Dickens's Literary Orphans, Alaina Gray

Master of Arts in Classical Studies

As a young child, Charles Dickens attached securely to his family. Through his strong literary relationship with his mother, Dickens learned to read well yet experienced a period of parental separation during his blacking factory employment, providing many opportunities to meet and interact with abandoned children, who pervade his novels. Baruch Hochman and Ilja Wachs describe the negative impacts of orphanhood in Dickens: The Orphan Condition. While Hochman and Wachs address the social and economic difficulties faced by Dickens’s literary orphans, they did not connect the orphan condition to impaired cognitive development. Experiencing an excellent literary relationship with his mother, …

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Density And Fiber Alignment Of The Fibrous Extracellular Matrix In Ovarian Cancer Metastases, Rachel Glantzberg, Aditi Singh, Mohammad Asghar Qanit Jan 2026

Density And Fiber Alignment Of The Fibrous Extracellular Matrix In Ovarian Cancer Metastases, Rachel Glantzberg, Aditi Singh, Mohammad Asghar Qanit

Wetterhahn Science Symposium Posters

The primary aim of this project is to improve and justify biophotonic approaches to label-free, non-invasive cancer detection, particularly within the context of peritoneal metastases from ovarian cancer. Ovarian cancer often metastasizes to the peritoneum, resulting in microanatomical changes in collagen and elastin fiber direction and density. While prior research has provided insights regarding collagen density changes in other types of cancer, peritoneal metastases from ovarian cancer remain minimally characterized, particularly in regards to elastin fibers. Preliminary results suggest that there is a difference in the elastin and collagen contents of healthy and cancerous tissues and that these contents differ …

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Litigating The "Forever Chemical" Problem Through The Endangered Species Act, Charlotte A. Ramirez Jan 2026

Litigating The "Forever Chemical" Problem Through The Endangered Species Act, Charlotte A. Ramirez

Emory Law Journal

Per- and polyfluoroalkyl substances (PFAS), a class of man-made, resiliently bonded chemicals, cause harm to both humans and animals. These “forever chemicals” can compromise immunity, increase cancer risks, and cause reproductive harm. Addressing the harms caused by PFAS variants is crucial to protect public health, environmental health, and biological diversity. However, the United States’ current regulatory scheme takes a disjointed approach to PFAS regulation. This is complicated by the frequent development of new PFAS variants, whose effects and environmental presence are largely unknown and understudied. While even the protections provided for humans under the current regulatory scheme fall short of …

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Techno-Optimism In Innovation Law And Policy, Peter Lee Jan 2026

Techno-Optimism In Innovation Law And Policy, Peter Lee

Emory Law Journal

This Article examines an underappreciated bias that has long pervaded U.S. legal culture: an exceedingly enthusiastic view of technology and technological progress. It adopts the term “techno-optimism” to describe an asymmetrically positive view of innovation that extols its benefits, minimizes its harms, and elides much of its complexity. The recent rise of more skeptical attitudes toward technology only casts into sharper relief the techno-optimism that has subtly dominated policy debates for decades. As a case study of techno-optimism, this Article scrutinizes patent law, particularly its constitutionally defined objective of promoting technological progress. In so doing, it offers the first extended …

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Mindfulness Practice And Increases In Gray Matter Density, Gray Matter Volume, And Cortical Thickness: A Scoping Review, Jason Brumitt Jan 2026

Mindfulness Practice And Increases In Gray Matter Density, Gray Matter Volume, And Cortical Thickness: A Scoping Review, Jason Brumitt

Faculty Publications - College of Physical Therapy

Background/Objectives: Mindfulness-based interventions (MBIs) have been linked to psychological and cognitive benefits, yet evidence for their impact on brain structure remains sparse. Neuroimaging suggests MBIs may alter gray matter volume (GMV), density (GMD), and cortical thickness (CT). The purpose of this scoping review was to investigate structural neuroplasticity following MBIs. Methods: Following PRISMA-ScR guidelines, databases were searched for studies published between 2010 and 2023 that used structural MRI to assess structural brain changes in subjects after receiving MBIs. Nine studies met inclusion criteria, including five randomized controlled trials. Results: Mindfulness interventions ranged from 10 h of training to long-term practice …

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Exploring Relational Farming Futures For Responsible Innovation In Precision Agriculture Through Q-Method And Speculative Design, Bhavna Joshi, Maaz Gardezi, Edward Prutzer, Awais Hameed Khan, Asim Zia, Benjamin E. K. Ryan, Ali Dadkhah, Donna M. Rizzo, John T. Mcmaine, David Clay Jan 2026

Exploring Relational Farming Futures For Responsible Innovation In Precision Agriculture Through Q-Method And Speculative Design, Bhavna Joshi, Maaz Gardezi, Edward Prutzer, Awais Hameed Khan, Asim Zia, Benjamin E. K. Ryan, Ali Dadkhah, Donna M. Rizzo, John T. Mcmaine, David Clay

Biosystems and Agricultural Engineering Faculty Publications

This article draws on concepts of speculative design and responsible innovation to examine the possible impacts of data-driven precision agriculture on farmers and farm work. We use an innovative mixed-method approach to research design. Using artistic depiction of futures of precision agriculture in design workshop and in-depth semistructured interviews conducted with the farmers in Vermont and South Dakota, we explain how farmers perceive different futures of precision agriculture. Specifically, in our design workshop, we combined visual arts and social science methods, namely Q-method, to explore existing and new relationships between humans, technologies, and environment in the design, deployment, and use …

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The Influence Of Adverse Childhood Experiences On Female Violent Offending: A Scoping Systematic Review, Alexis M. Wolgemuth Jan 2026

The Influence Of Adverse Childhood Experiences On Female Violent Offending: A Scoping Systematic Review, Alexis M. Wolgemuth

Theses, Dissertations and Capstones

Female-perpetrated violence has exhibited concerning data trends in recent years. Prior scholarship indicates that past victimization and trauma in childhood, known as adverse childhood experiences (ACEs), are highly prevalent among women offenders. However, the research concerning ACEs and violent females is scattered. This thesis provides a scoping literature review using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) updated 2020 guidelines. A systematic database search was conducted using Academic Search Complete, SAGE Journals, Springer Nature Link, and HeinOnline to identify relevant peer-reviewed journal articles. Inclusion and exclusion criteria are established, focusing on studies published after January 2015. These …

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Integrating Non-Binary Morphology Into Spanish Grammatical Gender: A Study On Native And Second-Language Speakers, Abigail H. Gustafson Jan 2026

Integrating Non-Binary Morphology Into Spanish Grammatical Gender: A Study On Native And Second-Language Speakers, Abigail H. Gustafson

Scripps Senior Theses

This study investigates how native (L1) and second-language (L2) Spanish speakers process non-binary gender morphology, focusing on the pronoun ‘elle’ and the adjective/noun ending ‘-e’. Prior studies show that native speakers outperform L2 speakers in processing traditional masculine–feminine agreement, non-binary forms and their emergence in a binary grammatical system are understudied. To address this gap, I conducted an online reaction-time experiment with bilingual speakers from the Claremont Colleges, who judged the grammaticality of Spanish sentences containing either grammatical gender or social gender (él/ella/elle) agreement and disagreement. Survey data also captured participants’ familiarity with and attitudes toward the pronoun ‘elle’. The …

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Temporal Evolution Of Brain Inflammation In The Bilateral Common Carotid Artery Stenosis Model Of Chronic Cerebral Hypoperfusion, Makayla F. Cox, Jill M. Roberts, Ryan K. Shahidehpour, David L. Dornbos Iii, Adam D. Bachstetter Jan 2026

Temporal Evolution Of Brain Inflammation In The Bilateral Common Carotid Artery Stenosis Model Of Chronic Cerebral Hypoperfusion, Makayla F. Cox, Jill M. Roberts, Ryan K. Shahidehpour, David L. Dornbos Iii, Adam D. Bachstetter

Neuroscience Faculty Publications

Chronic cerebral hypoperfusion is a major contributor to vascular cognitive impairment and dementia, primarily through its disruption of white matter integrity and promotion of neuroinflammatory cascades. The bilateral common carotid artery stenosis (BCAS) model has emerged as the predominant experimental approach for studying the effects of chronic cerebral hypoperfusion, particularly in aging-relevant contexts. This review synthesizes current knowledge of inflammatory responses in the BCAS model, with an emphasis on their temporal progression and functional consequences. We begin by outlining the clinical burden of hypoperfusion, the rationale for BCAS, and the hemodynamic phases it produces. We then examine early neurovascular unit …

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Dim Light At Night Impacts Circadian Rhythms And Alzheimer’S Disease-Like Neuroinf Lammation And Neuropathology In Humanized App Saa Knock-In Mice, Marilyn J. Duncan, Margaret R. Hawkins, Leke Bytyqi, Haleigh R. Whitlock, Savannah M. Shepard, Makayla F. Cox, Esther G. Drinkard, Teresa Macheda, Kelly N. Roberts, Katharina Kohler, Mary-Claire Schmidt, Carrie E. Johnson, Sridhar Sunderam, Bruce F. O'Hara, Michael Paul Murphy, Adam D. Bachstetter Jan 2026

Dim Light At Night Impacts Circadian Rhythms And Alzheimer’S Disease-Like Neuroinf Lammation And Neuropathology In Humanized App Saa Knock-In Mice, Marilyn J. Duncan, Margaret R. Hawkins, Leke Bytyqi, Haleigh R. Whitlock, Savannah M. Shepard, Makayla F. Cox, Esther G. Drinkard, Teresa Macheda, Kelly N. Roberts, Katharina Kohler, Mary-Claire Schmidt, Carrie E. Johnson, Sridhar Sunderam, Bruce F. O'Hara, Michael Paul Murphy, Adam D. Bachstetter

Neuroscience Faculty Publications

Artificial light at night (light pollution) is widespread but understudied in the context of Alzheimer’s disease (AD). Sleep and circadian disruption have been linked to amyloid-β (Aβ) accumulation and neuroinflammation, but whether dim light at night (dLAN) modifies these processes remains unclear. We tested whether chronic dLAN exposure (8 lux during the dark phase, 8 weeks) alters circadian rhythms, amyloid pathology, and neuroinflammation in 12–13 month-old humanized APP knock-in (KI) mice. hAPPSAA KI mice, which develop plaques, were compared with hAPPWT KI controls carrying only a humanized APP sequence. dLAN reduced circadian rhythm amplitude and stability while increasing …

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A Descriptive Study Of Culturally Responsive Practices In Positive Behavioral Interventions And Supports (Pbis) In West Virginia Elementary Schools, Janna Rae Coleman Jan 2026

A Descriptive Study Of Culturally Responsive Practices In Positive Behavioral Interventions And Supports (Pbis) In West Virginia Elementary Schools, Janna Rae Coleman

Theses, Dissertations and Capstones

This descriptive mixed-methods study examined elementary teachers’ implementation and perceived effectiveness of culturally responsive practices within existing Positive Behavioral Interventions and Supports (PBIS) systems in a West Virginia school district. Guided by Leverson et al.’s (2021) Culturally Responsive PBIS (CRPBIS) framework, the study explored five components of culturally responsive practice: identity, voice, supportive environment, situational appropriateness, and data for equity. Both quantitative and qualitative data were collected from 86 elementary teachers using the researcher-developed Culturally Responsive Practices in Existing PBIS Survey. Findings indicated that teachers reported frequent implementation and perceived effectiveness across all five components, with the supportive environment receiving …

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Phonology, Geoffrey S. Nathan Jan 2026

Phonology, Geoffrey S. Nathan

English Faculty Research Publications

This paper explores the ways in which phonology is both structured by the same principles as other aspects of language but is also different, because the interaction between the substance of phonology and the human bodies used to produce and perceive it are much more tightly integrated than is the case with the structures of words, sentences and other aspects of language. Cognitive Grammar holds that the structure of language is abstracted from its use (the theory is ‘usage-based’), and this has resulted in views of the nature of language that differ radically from the dominant generative paradigm. However, the …

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Brain-Derived Extracellular Vesicles Potentially Mediate Crosstalk With Peripheral Organs In Neurodegenerative Diseases, Ramzi H. Hamdalla, Vibha B. Bhaskar, Changhai Tian Jan 2026

Brain-Derived Extracellular Vesicles Potentially Mediate Crosstalk With Peripheral Organs In Neurodegenerative Diseases, Ramzi H. Hamdalla, Vibha B. Bhaskar, Changhai Tian

Toxicology and Cancer Biology Faculty Publications

Brain-Derived Extracellular vesicles (BDEVs) are emerging mediators of intra- and interorgan communication in neurodegenerative diseases (NDs) such as Alzheimer’s Disease (AD) and Parkinson’s Disease (PD). A growing body of evidence suggests that BDEVs play an important role in modulating intercellular communication within the central nervous system in the pathogenesis of many NDs. By transporting non-coding RNAs (e.g., miRNAs) and important pathological proteins, BDEVs also influence peripheral organs and contribute to the progression of disease in the central nervous system (CNS). This review extends the understanding of NDs beyond solely brain dysfunction and gives a novel framework for the progression of …

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Liposome-Encapsulated Clodronate And Cox-2 Inhibitor Treatment Impair Ventilatory Recovery But Improve Compensatory Locomotor Function Following Cervical Spinal Cord Injury In Rats, Aaron L. Silverstein, Chris M. Calulot, Christopher J. Mclouth, John C. Gensel, Warren J. Alilain Jan 2026

Liposome-Encapsulated Clodronate And Cox-2 Inhibitor Treatment Impair Ventilatory Recovery But Improve Compensatory Locomotor Function Following Cervical Spinal Cord Injury In Rats, Aaron L. Silverstein, Chris M. Calulot, Christopher J. Mclouth, John C. Gensel, Warren J. Alilain

Spinal Cord and Brain Injury Research Center Faculty Publications

Over half of all spinal cord injuries (SCIs) in the United States occur at the cervical level and can cause locomotor deficits and life-threatening breathing dysfunction. Interestingly, the bisphosphonate drug clodronate has shown efficacy in ameliorating tissue damage and improving locomotor recovery acutely after experimentally induced thoracic SCI. Thus, we hypothesized that clodronate treatment would improve recovery of breathing and locomotor function following a C2 hemisection (C2Hx) model of cervical SCI in rats. Serendipitously, changes to animal use guidelines led to the inclusion of carprofen, a non-steroidal anti-inflammatory drug (NSAID), as another independent variable in our study. We treated adult …

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Feeding The Family—A Food Is Medicine Intervention: Preliminary Baseline Results Of Clinical Data From Caregivers And Children, Gabriela Drucker, Christa Mayfield, Elizabeth T. Anderson Steeves, Sara Maksi, Tabitha Underwood, Julie Brown, Marissa Frick, Alison Gustafson Jan 2026

Feeding The Family—A Food Is Medicine Intervention: Preliminary Baseline Results Of Clinical Data From Caregivers And Children, Gabriela Drucker, Christa Mayfield, Elizabeth T. Anderson Steeves, Sara Maksi, Tabitha Underwood, Julie Brown, Marissa Frick, Alison Gustafson

Behavioral Science Faculty Publications

Background/Objectives: Food is Medicine (FIM) programs have been shown to be effective at addressing food and nutrition insecurity among individuals. However, more evidence is needed to determine effective interventions at the household level and their impact on child health outcomes. Feeding the Family is a randomized controlled trial which aims to determine whether the amount of food provided and the ability to select foods in FIM interventions have an incremental effect on child and caregiver clinical outcomes relative to nutrition counseling alone. The objective of this paper is to describe the population at baseline among those enrolled in Feeding the …

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