Digital Commons Network^™

The Analysis Of Microdroplet Arrays, Alex Austin

Mechanical Engineering and Materials Science Independent Study

The primary objective of my research this semester was the investigation into the optimization of the micropillar array both through simulations and physical testing. Where ancillary objectives include the familiarization of SEM imaging, Surface Evolver, and COMSOL. Significant progress has been made in all these objectives. Specifically in the construction of different asymmetrical droplets that were combined to form an array.

The Mrna-Lnp Platform's Lipid Nanoparticle Component Used In Preclinical Vaccine Studies Is Highly Inflammatory, Sonia Ndeupen, Zhen Qin, Sonya Jacobsen, Aurélie Bouteau, Henri Estanbouli, Botond Z. Igyártó

Department of Microbiology and Immunology Faculty Papers

Vaccines based on mRNA-containing lipid nanoparticles (LNPs) are a promising new platform used by two leading vaccines against COVID-19. Clinical trials and ongoing vaccinations present with varying degrees of protection levels and side effects. However, the drivers of the reported side effects remain poorly defined. Here we present evidence that Acuitas' LNPs used in preclinical nucleoside-modified mRNA vaccine studies are highly inflammatory in mice. Intradermal and intramuscular injection of these LNPs led to rapid and robust inflammatory responses, characterized by massive neutrophil infiltration, activation of diverse inflammatory pathways, and production of various inflammatory cytokines and chemokines. The same dose of …

Environmental Influence On Size Frequency Distributions Of The Pacific Blue Mussel (Mytilus Trossulus) In Two Glacially Inlfuenced Estuaries, Amy Dowling

Marine Biology

The Pacific blue mussel (Mytilus trossulus) is a foundation species in high-latitude intertidal and estuarine systems that can create complex habitats, provide sediment stability, serve as food for top predators, and act as connectors between the water column and the benthos. M. trossulus also makes an ideal model species to assess biological responses to environmental variability, as its size frequency distributions can be influenced by the environment in which it lives. Size frequency distributions can provide valuable information about ecological systems that are experiencing environmental change (e.g., increased global temperatures). M. trossulus populations in high latitude estuaries receive freshwater runoff …

Fasting Status Of Steller Sea Lion Pups, Stephanie G. Crawford

Biological Sciences

Following population declines in species of concern, wildlife managers often seek to identify underlying causes to understand and predict population dynamics for better future management. Often, physiological and/or behavioral metrics are measurable markers of decline, and these are often detectable well before declines are measurable through population surveys. During the 1970's, 80's, and 90's Steller sea lion (SSL; Eumetopias jubatus) populations in the western portion of their breeding range declined by ~85%. Though declines in most regions have since stabilized or exhibited modest recovery, some subpopulations breeding in the Aleutian Islands continue to decline. In contrast, SSL subpopulations in eastern …

Rooted In Environmental Justice: Phytogeography And Ethnoecology Of Serianthes, Else Demeulenaere

Biological Sciences

Serianthes Benth. (Fabaceae) is one of the most endangered plant genera in the world, with 12 of the 18 species listed on the IUCN Red List of Threatened Species. Serianthes trees are culturally important to island communities of the Indo-Pacific region for canoes, boats, traditional houses, and medicine. Habitat loss and ecosystem degradation increased pressure on these trees, also threatening its Indigenous cosmology and traditional practices. This interdisciplinary study integrated genomic, biogeographic and ethnoecological approaches to develop appropriate policies that protect the Indigenous biocultural diversity of Serianthes. Phylogenomics of 401 nuclear exons and non-coding flanking regions using both a multi-species …

Immunological Factors Associated With Siv/ Shiv Persistence In Diverse Tissue Niches, Omalla A. Olwenyi

Theses & Dissertations

The significant challenge towards a successful HIV cure lies in eradicating persistent viral reservoirs across diverse tissue niches. As a result, HIV-infected individuals have to resort to lifelong antiretroviral therapy. Recent news of supposed HIV eradication in a second patient has further re-invigorated the fields of HIV cure. However, a few barriers remain, such as the lack of currently available assays to accurately quantify viral reservoirs, limited information on cellular factors associated with persistence, and varied dynamics of the viral reservoir in various body compartments. Lastly, HIV-infected individuals live different lifestyles stemming from comorbid substance abuse including consumption of morphine, …

Otolith Derived Hatch Dates, Growth Rates, And Microchemistry Of Arctic Cod (Boreogadus Saida) Support The Existence Of Several Spawning Populations In Alaskan Waters, Zane M. Chapman

Fisheries

The changing climate in the Arctic is resulting in increased air and water temperatures as well as a reduction in sea ice, affecting native species that evolved to live in the unique habitats of the Arctic Ocean. One species of significant importance to Arctic marine ecosystems is the Arctic Cod (Boreogadus saida), a keystone species that serves as vital prey for many marine mammals, seabirds, and fishes. Arctic Cod have a strong association with sea ice for spawning and for much of their early life history. In the Pacific Arctic, little is known about their early life history, especially with …

The Effects Of Ocean Acidification And Warming On The Metabolic Physiology Of Juvenile Northern Spot Shrimp (Pandalus Platyceros), Jamie Lee Musbach

Fisheries

Northern spot shrimp (Pandalus platyceros) support important commercial, subsistence, sport, and personal use fisheries in Alaska. This species is currently experiencing population declines in Southeast Alaska, mandating fishery closures in previously productive regions. Northern spot shrimp are harvested as adults and declining populations may be a result of limited recruitment into the fishery. Very little is known about the physiology of P. platyceros early life history stages and no known data exists on how early life history stages may be affected by environmental stressors such as ocean acidification (OA) and ocean warming (OW). OA is a result of increased anthropogenic …

Ultrasound Modulation Of Macaque Prefrontal Cortex Selectively Alters Credit Assignment–Related Activity And Behavior, Davide Folloni, Elsa Fouragnan, Marco K. Wittmann, Lea Roumazeilles, Lev Tankelevitch, Lennart Verhagen, David Attali, Jean François Aubry, Jerome Sallet, Matthew F.S. Rushworth

School of Psychology

Credit assignment is the association of specific instances of reward to the specific events, such as a particular choice, that caused them. Without credit assignment, choice values reflect an approximate estimate of how good the environment was when the choice was made—the global reward state—rather than exactly which outcome the choice caused. Combined transcranial ultrasound stimulation (TUS) and functional magnetic resonance imaging in macaques demonstrate credit assignment–related activity in prefrontal area 47/12o, and when this signal was disrupted with TUS, choice value representations across the brain were impaired. As a consequence, behavior was no longer guided by choice value, and …

Connecting Human Dignity, Non-Violence, And Environment For Healthcare Ethics In Nigeria, John Mark Ogu

Electronic Theses and Dissertations

Abstract

Connecting Human Dignity, Non-violence, and Environment in Health Care for Nigeria

By

John Mark Chinaemerem Ogu

December 2021

Dissertation supervised by Peter Ikechukwu Osuji, Ph.D.

This dissertation presents a global public health ethical approach based on social justice that connects human dignity, non-violence, and the environment in Nigeria. Recently, different places globally are witnessing uprisings and violence; some of these are linked to environmental scarcity. These are threats to global health, peace, development, and security because violence of any type or form is a global public health and security menace and an affront to human dignity. Environmental scarcity, especially …

Sacubitril/Valsartan Versus Angiotensin Inhibitors And Arrhythmia Endpoints In Heart Failure With Reduced Ejection Fraction, Sandra Chaparro

All Publications

No abstract provided.

Influence Of Grassland Management And Grazing By Different Farm Animals On Animal Performance And Flora Alterations, W. Jentsch, H.-D. Matthes, A. Admasu, H. Möhring

IGC Proceedings (1977-2023)

The objectives of this study were to test the possibilities of using different farm animals for landscape care on extensive pasture, taking into account their particular performance, and to analyse alterations of the flora in consequence of grazing by different animals and various pasture management. Salers had the highest (836g/d) and Galloways (584g/d) the lowest live weight gain as compared with the other breeds (771g/d). Lambs had higher live weight when grazing together with cattle and horses (mixed grazing) than under one species grazing. The number of legume increased and that of grass decreased. Following 3 years the grazing animals …

Animal Production From Tropical Pastures Renovated By Subsoiling And Fertilization In The Cerrados Of Brazil, Valéria P. B. Euclides, Manuel C. M. Macedo, M. P. Oliveira

IGC Proceedings (1977-2023)

A grazing trial was conducted, to study the effects of fertilization on the maintenance of the productivity of four tropical grasses. The paddocks were subsoiled, and dived into halves: one (LF1) received 400 kg/ha of a fertilizer formula 0-20-20.and the other (LF2) 800 kg/ha of the same fertilizers, in January 1995. Annually, 50 kg/ha of N was applied. The productivity on LF2 pastures was greater than that on FL1 pastures, averaging 520 and 410 kg of liveweight gain/ha/year. A double strategy should be followed to sustain animal production in the savanna: maintain soil P over a critical value of 3.0 …

Performance Of Nellore Cattle Under Two Grazing Management Systems, L. De A. Corrêa, Maurício M. De Alencar, Rogério T. Barbosa, P. F. Barbosa, Geraldo M. Da Cruz, I. U. Packer, C. A. Cordeiro

IGC Proceedings (1977-2023)

The objective of this study was to evaluate the effects of grazing intensification on birth weight (BW), weaning weight (WW, standartized to 205 days), average daily gain from birth to weaning (ADG), and gestation length (GL) of calves, cow weight at calving (CWC) and at weaning (CWW), cow condition score at calving (CCC) and at weaning (CCW), and BW/CWC (BWR), WW/CWC (WWRC) and WW/CWW (WWRW) ratios. One hundred and sixty eight Nellore calves born in 1998 and 1999, out of dams maintained in two grazing management systems were evaluated: an extensive 1.0 animal unity (AU). ha^-1 system on unfertilized …

Orchardgrass Pastures For Early-Weaned Beef Calves, J. C. Waller, H. A. Fribourg, C. Dixon, A. E. Fisher, B. V. Conger

IGC Proceedings (1977-2023)

Orchardgrass (Dactylis glomerata) grown alone or with ladino white (Trifolium repens) and red (T. pratense) clovers, provides a high quality March to June pasture. However, many beef producers have their cows calving in January-March, thus producing offspring that are too young to utilize spring forage well. As an alternative, some producers have their cows bred so that calves are born in autumn (September-November). By spring, these calves are old enough to consume pasture forage. The few earlier studies on early weaning of fall-born calves consist of drylot feeding of high quality hay or concentrates. …

Challenging Solitary Confinement Through State Constitutions, Alison Gordon

University of Cincinnati Law Review

Eighth Amendment jurisprudence has resulted in limited scrutiny of solitary confinement despite the known harms associated with the practice. The two-part test established by the federal courts to evaluate Eighth Amendment claims and limitations on challenging prison conditions under the Prison Litigation Reform Act can make it difficult to establish that solitary confinement is cruel and unusual punishment.

State constitutional challenges to solitary confinement are underexplored. Nearly all state constitutions contain an equivalent provision to the Eighth Amendment’s prohibition on cruel and unusual punishment. State courts need not be bound by federal jurisprudence in interpreting the scope of the state …

Authority, Obedience, And Justification, Michelle Madden Dempsey

University of Cincinnati Law Review

We have a duty to think for ourselves. The law claims authority over us. We have a duty, at least sometimes, to obey the law. Alone, each of these premises is fairly uncontroversial. Combined, they create some intriguing puzzles. Can law’s claim of authority be justified? If so, does justified legal authority entail an obligation to obey the law? If not, are we nonetheless justified, and perhaps even obligated, to act as if such an obligation exists? While this essay is hardly the first to address these questions, it is the first to do so by combining elements of Joseph …

Moby-Dick As Corporate Catastrophe: Law, Ethics, And Redemption, David Yosifon

University of Cincinnati Law Review

Herman Melville’s Moby-Dick serves here as a vehicle through which to interrogate core features of American corporate law and excavate some of the deeper lessons about the human soul that lurk behind the pasteboard mask of the law’s black letter. The inquiry yields an illuminating vantage on the ethical consequences of corporate capital structure, the law of corporate purpose, the meaning of voluntarism, the ethical stakes of corporate fiduciary obligations, and the role of lawyers in preventing or facilitating corporate catastrophe. No prior familiarity with the novel or corporate law is required.

Online Chinese Learning: A Case Study Of The Use Of Youtube Instructional Videos, Mireia Vargas-Urpí, Yanjun Xu

Chinese Language Teaching Methodology and Technology

YouTube is one of many online platforms that provide good, free learning resources for students of Chinese as a foreign language (CFL). This article aims to explore the role and implications of YouTube videos in CFL education. To that end, it firstly introduces a questionnaire survey conducted among Chinese language learners in Barcelona, Spain, focusing on their viewing habits related to YouTube Chinese-learning videos. The results of the survey not only reveal the students’ preferences for certain types of video content/formats, but also indicate that they make only very limited use of YouTube resources to supplement their formal language education. …

Vol.49 N.22 December 16th 2021, Voice Media Ventures

Black Voice News

No abstract provided.

Magnitude And Uncertainty Of Nitrous Oxide Emissions From North America Based On Bottom-Up And Top-Down Approaches: Informing Future Research And National Inventories, R. Xu, Hanqin Tian, N. Pan, R. L. Thompson, J. G. Canadell, E. A. Davidson, C. Nevison, W. Winiwarter, H. Shi, S. Pan, J. Chang, P. Ciais, Shree Dangal, A. Ito, R. B. Jackson, F. Joos, R. Lauerwald, S. Lienert, T. Maavara, D. B. Millet, P. A. Raymond, P. Regnier, F. N. Tubiello, N. Vuichard, K. C. Wells, C. Wilson, J. Yang, Y. Yao, S. Zaehle, F. Zhou

School of Natural Resources: Faculty Publications

We synthesized N₂O emissions over North America using 17 bottom-up (BU) estimates from 1980– 2016 and five top-down (TD) estimates from 1998 to 2016. The BU-based total emission shows a slight increase owing to U.S. agriculture, while no consistent trend is shown in TD estimates. During 2007–2016, North American N₂O emissions are estimated at 1.7 (1.0–3.0) Tg N yr⁻¹ (BU) and 1.3 (0.9–1.5) Tg N yr⁻¹ (TD). Anthropogenic emissions were twice as large as natural fluxes from soil and water. Direct agricultural and industrial activities accounted for 68% of total anthropogenic emissions, 71% of …

Skin Bacterial Metacommunities Of San Francisco Bay Area Salamanders Are Structured By Host Genus And Habitat Quality., Shannon Buttimer, Obed Hernandez-Gomez, Erica Bree Rosenblum

Natural Sciences and Mathematics | Faculty Scholarship

Host-associated microbial communities can influence physiological processes of macroorganisms, including contributing to infectious disease resistance. For instance, some bacteria that live on amphibian skin produce antifungal compounds that inhibit two lethal fungal pathogens, Batrachochytrium dendrobatidis (Bd) and Batrachochytrium salamandrivorans (Bsal). Therefore, differences in microbiome composition among host species or populations within a species can contribute to variation in susceptibility to Bd/Bsal. This study applies 16S rRNA sequencing to characterize the skin bacterial microbiomes of three widespread terrestrial salamander genera native to the western United States. Using a metacommunity structure analysis, we identified dispersal barriers for these influential bacteria between salamander …

Fractales, Office Of Arts + Cultural Programming, Peak Performances At Montclair State University

2021-2022 Join Us in Engaging with the Imaginations of Unparalleled Visionaries

The language of the circus and dance movement highlight the physical potential of the acrobatic body as performers are confronted by a landscape in transformation. Circus and danced movement induce a slow metamorphosis of humans and organic matter, as performers confront nature, accompany it, dodge it, collide, and merge with it. Nothing here has a beginning or an end, but is part of a continuum.

Saving Tigers In America:- Part 1, Andrew Rowan

Tales of WellBeing

In the first of three articles, WBI President Andrew Rowan describes the history of how America arrived at the point where it has twice as many tigers as there are wild tigers in the rest of the world.

Fractales, Office Of Arts + Cultural Programming, Peak Performances At Montclair State University

2020-2021 Launch of PEAK HD and PEAK PLUS

The language of the circus and dance movement highlight the physical potential of the acrobatic body as performers are confronted by a landscape in transformation. Circus and danced movement induce a slow metamorphosis of humans and organic matter, as performers confront nature, accompany it, dodge it, collide, and merge with it. Nothing here has a beginning or an end, but is part of a continuum.

Family Planning And Its Limits, Dov Fox

The Journal of Contemporary Legal Issues

A doctor botches a vasectomy. Or says it’d be dangerous to keep a healthy pregnancy. Or misses a risk of passing along disease. Our laws do little to deter such reproductive negligence or compensate its victims. Some of this misconduct leaves people without the baby they desperately want. Other times, it foists on parents a child they’d set out to avoid. Or one with meaningfully different traits than what they were led to believe.

I call these three harms procreation deprived, procreation imposed, and procreation confounded.

Thousands of fertility patients were deprived of biological parenthood when their …

Utilizing Isothermal Titration Calorimetry For Measuring Beta-Galactosidase Activity In Liquid Dairy Products, Eliza Anne Brock

Theses and Dissertations

This research explores Isothermal Titration Calorimetry as a method for measuring beta-galactosidase activity directly and continuously in milk, sweet whey, sweet whey permeate, acid whey, and acid whey permeate. Beta-galactosidase in various concentrations was injected into each of the liquid dairy products spiked with lactose to verify if the heat rate from the enzymatic reaction could be observed. In addition, a consistent concentration of beta-galactosidase was injected into various concentrations of lactose in the products, to observe the heat rates from the enzymatic reaction. There was exothermic activity that never returned to baseline demonstrated in milk, sweet whey, and sweet …

Fear, Loathing, And The Hemispheric Consequences Of Xenophobic Hate, Ernesto Sagás, Ediberto Román

University of Miami International and Comparative Law Review

“When you have fifteen thousand people marching up . . . how do you stop these people?” “You shoot them” [crowd member shouts] [chuckling, Trump responds:] “[O]nly in the Panhandle can you get away with that thing.”¹
President Donald Trump

“Thousands of criminal aliens. They’re pouring into our country.”²
President Donald Trump

“They’re not people, these are animals.”³
President Donald Trump

“Take a look at the death and destruction that’s been caused by people coming into this country caused by people that shouldn’t be here.”⁴
President Donald Trump

“ [We] have millions and millions of people …

Ecological Exposure And Effects Of Microplastics In Crabs Along The Pacific Coast, Dorothy A. Horn

Dissertations and Theses

Microplastics have been documented across the global oceans as an ubiquitous pollutant. Found in the water column, sediment, shorelines, estuaries, freshwater streams and rivers along with terrestrial soils, flora and fauna. The continuous input of plastic waste into the marine environment doesn't seem to be slowing as the amount of plastic created each year increases globally.

This study investigated (1) the effects of microplastic ingestion in the indicator species, the Pacific mole crab (Emerita analoga), testing the predator avoidance behavior, reproductive output and parasitism effects when an adult female gravid crab had ingested microplastics (2) adult mortality, hatching …

Contextualizing Caves Within An Animate Maya Landscape: Caves As Living Agents In The Past And Present, Brent K. S. Woodfill

KIP Articles

After groundbreaking work by multiple archaeologists in the latter half of the 20th century, caves in the Maya world are currently acknowledged as fundamentally ritual rather than domestic spaces. However, a more nuanced read of the anthropological literature and conversations with Indigenous collaborators in the past and present pushes us to move still farther and see caves not as passive contexts to contain ceremonies directed elsewhere but animate beings with unique identities and personalities in their own right. This article combines archaeological, ethnohistoric, and ethnographic documentation of Maya cave use in central Guatemala to build a foundation for examining caves …