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Closely Related Gull Species Show Contrasting Foraging Strategies In An Urban Environment, K. A. Lato, D. J. Madigan, R. R. Veit, L. H. Thorne Dec 2021

Closely Related Gull Species Show Contrasting Foraging Strategies In An Urban Environment, K. A. Lato, D. J. Madigan, R. R. Veit, L. H. Thorne

Publications and Research

The expansion of urban landscapes has both negative and positive effects on wildlife. Understanding how different species respond to urbanization is key to assessing how urban landscapes influence regional wildlife behavior and ecosystem structure. Gulls are often described as strong urban adapters, but few studies have explored species-specific differences in habitat use. Here, we use GPS tracking in conjunction with stable isotope analysis (SIA) to quantify the habitat use and trophic ecology of great black-backed gulls (Larus marinus) and herring gulls (L. argentatus) in an urbanized area. Non-Metric Multidimensional Scaling (NMDS) of foraging locations revealed significant differences in the habitat …

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Limited Range-Filling Among Endemic Forest Herbs Of Eastern North America And Its Implications For Conservation With Climate Change, Stephanie K. Erlandson, Jesse Bellemare, David A. Moeller Dec 2021

Limited Range-Filling Among Endemic Forest Herbs Of Eastern North America And Its Implications For Conservation With Climate Change, Stephanie K. Erlandson, Jesse Bellemare, David A. Moeller

Biological Sciences: Faculty Publications

Biodiversity hotspots host a high diversity of narrowly distributed endemic species, which are increasingly threatened by climate change. In eastern North America, the highest concentration of plant diversity and endemism occurs in the Southern Appalachian Mountains (SAM). It has been hypothesized that this region served as a refugium during Pleistocene glacial cycles and that postglacial migration northward was dispersal limited. We tested this hypothesis using species distribution models for eight forest herb species. We also quantified the extent to which the geography of suitable habitat shifted away from the current range with climate change. We developed species distribution models for …

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Ecological And Morphological Differentiation Among Coi Haplotype Groups In The Plant Parasitic Nematode Species Mesocriconema Xenoplax, Julianne N. Matczyszyn, Timothy Harris, Kirsten S. Powers, Sydney E. Everhart, Thomas O. Powers Dec 2021

Ecological And Morphological Differentiation Among Coi Haplotype Groups In The Plant Parasitic Nematode Species Mesocriconema Xenoplax, Julianne N. Matczyszyn, Timothy Harris, Kirsten S. Powers, Sydney E. Everhart, Thomas O. Powers

Department of Plant Pathology: Faculty Publications

DNA barcoding with the mitochondrial COI gene reveals distinct haplotype subgroups within the monophyletic and parthenogenetic nematode species, Mesocriconema xenoplax. Biological attributes of these haplotype groups (HG) have not been explored. An analysis of M. xenoplax from 40 North American sites representing both native plant communities and agroecosystems was conducted to identify possible subgroup associations with ecological, physiological, or geographic factors. A dataset of 132 M. xenoplax specimens was used to generate sequences of a 712 bp region of the cytochrome oxidase subunit I gene. Maximum-likelihood and Bayesian phylogenies recognized seven COI HG (≥99/0.99 posterior probability/bootstrap value). Species delimitation …

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Ecological And Morphological Differentiation Among Coi Haplotype Groups In The Plant Parasitic Nematode Species Mesocriconema Xenoplax, Julianne N. Matczyszyn, Timothy Harris, Kirsten S. Powers, Sydney E. Everhart, Tom Powers Dec 2021

Ecological And Morphological Differentiation Among Coi Haplotype Groups In The Plant Parasitic Nematode Species Mesocriconema Xenoplax, Julianne N. Matczyszyn, Timothy Harris, Kirsten S. Powers, Sydney E. Everhart, Tom Powers

Department of Plant Pathology: Faculty Publications

DNA barcoding with the mitochondrial COI gene reveals distinct haplotype subgroups within the monophyletic and parthenogenetic nematode species, Mesocriconema xenoplax. Biological attributes of these haplotype groups (HG) have not been explored. An analysis of M. xenoplax from 40 North American sites representing both native plant communities and agroecosystems was conducted to identify possible subgroup associations with ecological, physiological, or geographic factors. A dataset of 132 M. xenoplax specimens was used to generate sequences of a 712 bp region of the cytochrome oxidase subunit I gene. Maximum-likelihood and Bayesian phylogenies recognized seven COI HG (≥99/0.99 posterior probability/bootstrap value). Species …

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Global Analysis Of Differential Gene Expression Within The Porcine Conceptus Transcriptome As It Transitions Through Spherical, Ovoid, And Tubular Morphologies During The Initiation Of Elongation, Sophie C. Walsh, Jeremy R. Miles, Brittney N. Keel, Lea A. Rempel, Elane C. Wright‐Johnson, Amanda K. Lindholm‐Perry, William T. Oliver, Angela K. Pannier Dec 2021

Global Analysis Of Differential Gene Expression Within The Porcine Conceptus Transcriptome As It Transitions Through Spherical, Ovoid, And Tubular Morphologies During The Initiation Of Elongation, Sophie C. Walsh, Jeremy R. Miles, Brittney N. Keel, Lea A. Rempel, Elane C. Wright‐Johnson, Amanda K. Lindholm‐Perry, William T. Oliver, Angela K. Pannier

Department of Agricultural and Biological Systems Engineering: Faculty Publications

This study aimed to identify transcriptome differences between distinct or transitional stage spherical, ovoid, and tubular porcine blastocysts throughout the initiation of elongation. We performed a global transcriptome analysis of differential gene expression using RNA‐Seq with high temporal resolution between spherical, ovoid, and tubular stage blastocysts at specific sequential stages of development from litters containing conceptus populations of distinct or transitional blastocysts. After RNA‐Seq analysis, significant differentially expressed genes (DEGs) and pathways were identified between distinct morphologies or sequential development stages. Overall, 1898 significant DEGs were identified between distinct spherical and ovoid morphologies, with 311 total DEGs between developmental stages …

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Practical Considerations Of Dissolved Oxygen Levels For Platelet Function Under Hypoxia, Branden Kusanto, Andrew Gordon, Leigh Naylor-Adamson, Lloyd Atkinson, Charlie Coupland, Zoe Booth, Yusra Ahmed, Isabel M Pires, Graeme J Stasiuk, Roger Sturmey, Simon D J Calaminus, Mònica Arman Dec 2021

Practical Considerations Of Dissolved Oxygen Levels For Platelet Function Under Hypoxia, Branden Kusanto, Andrew Gordon, Leigh Naylor-Adamson, Lloyd Atkinson, Charlie Coupland, Zoe Booth, Yusra Ahmed, Isabel M Pires, Graeme J Stasiuk, Roger Sturmey, Simon D J Calaminus, Mònica Arman

Faculty, Staff and Student Publications

Investigating human platelet function in low-oxygen environments is important in multiple settings, including hypobaric hypoxia (e.g., high altitude), sea level hypoxia-related disease, and thrombus stability. These studies often involve drawing blood from which platelets are isolated and analysed at atmospheric conditions or re-exposed to low oxygen levels in hypoxia chambers before testing. However, it remains unknown how the in vitro handling of the samples itself changes their dissolved oxygen concentration, which might affect platelet function and experimental results. Here, we prepared healthy donor platelet-rich plasma and washed platelet (WP) suspensions and exposed them to 2% oxygen. We found that the …

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11 Pressing Research Questions On How Light Pollution Affects Biodiversity, Franz Holker, Janine Bolliger, Thomas W. Davies, Simone Giavi, Andreas Jechow, Gregor Kalinkat, Travis Longcore, Kamiel Spoelstra, Svenja Tidau, Marcel E. Visser, Eva Knopp Dec 2021

11 Pressing Research Questions On How Light Pollution Affects Biodiversity, Franz Holker, Janine Bolliger, Thomas W. Davies, Simone Giavi, Andreas Jechow, Gregor Kalinkat, Travis Longcore, Kamiel Spoelstra, Svenja Tidau, Marcel E. Visser, Eva Knopp

School of Biological and Marine Sciences

Artificial light at night (ALAN) is closely associated with modern societies and is rapidly increasing worldwide. A dynamically growing body of literature shows that ALAN poses a serious threat to all levels of biodiversity—from genes to ecosystems. Many “unknowns” remain to be addressed however, before we fully understand the impact of ALAN on biodiversity and can design effective mitigation measures. Here, we distilled the findings of a workshop on the effects of ALAN on biodiversity at the first World Biodiversity Forum in Davos attended by several major research groups in the field from across the globe. We argue that 11 …

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Effects Of Inclusive Social Skills Training On Preschoolers, Lauren E. Weiss Dec 2021

Effects Of Inclusive Social Skills Training On Preschoolers, Lauren E. Weiss

Special Education ETDs

Social interventions for children with disabilities are generally conducted in small groups and outside of the classroom; therefore, little is known about inclusive and classwide social interventions in early childhood educational settings. This study evaluated the effects of inclusive social skills training (ISST), a program delivered remotely to inclusive preschool classrooms via direct instruction, video modeling, rehearsal, and feedback, to teach social skills. Educators rated preschoolers' social skills in a nonequivalent pretest-posttest design and evaluated the social validity of ISST. I examined the differences in scores. A significant interaction effect was detected in the program group between abilities. Overall, educators …

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Intake Estimation Of Rams Under Grazing Condition In A Deferred Pastures Of Panicum Coloratum By Two Techniques, C. M. Ferri, M. A. Brizuela, N. P. Stritzler, H. J. Petruzzi Dec 2021

Intake Estimation Of Rams Under Grazing Condition In A Deferred Pastures Of Panicum Coloratum By Two Techniques, C. M. Ferri, M. A. Brizuela, N. P. Stritzler, H. J. Petruzzi

IGC Proceedings (1977-2023)

The goal of this study was to quantify the organic matter intake (OMI) of Pampinta rams grazing in a Panicum coloratum cv Verde differed pasture. The OMI was compared by two methods: a) the difference between the forage measured in pre and post-grazing condition, and b) the faecal production:digestibility ratio of the diet, estimated by total faecal gathering, and from the quantity of total faecal N in g per 100 g-1 of OMI and the concentration of total faecal N, respectively. The OMI estimated by difference between the forage measured in pre and post-grazing was 9 % higher (P …

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Estimation Of Organic Matter Digestibility And Intake From Faecal Organic Matter And Daily N Excretion And Concentration, C. M. Ferri, N. P. Stritzler, M. A. Brizuela Dec 2021

Estimation Of Organic Matter Digestibility And Intake From Faecal Organic Matter And Daily N Excretion And Concentration, C. M. Ferri, N. P. Stritzler, M. A. Brizuela

IGC Proceedings (1977-2023)

This study was performed with grazing sheep, to establish: a) if the amount of total faecal N (C; in g 100g-1 of organic matter intake (OMI)) remains constant at three feeding levels, in four utilisation periods of deferred Panicum coloratum cv. Verde; b) the relationship between C and faecal N fractions, and c) the relationship between faecal daily excretion of OM and N, and OMI. Intake increased (P< 0.01) with utilisation period, and was related (r = - 0.82; P< 0.01) to the protein content of food, the insoluble N fraction (r = -0.49; P< 0.01) and the soluble:insoluble N ratio (r = 0.41; P< 0.01) in faeces. No relation with total N concentration (r = -0.22; P> 0.05) or soluble N fraction (r = -0.02; P> 0.05) in faeces could be found. Daily excretion of OM and N were positively related (R2 = 0.93 and 0.96, respectively; …

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Book Reviews, Florida Historical Society Dec 2021

Book Reviews, Florida Historical Society

Florida Historical Quarterly

THE MILITARY PRESENCE ON THE GULF COAST: GULF COAST HISTORY AND HUMANITIES CONFERENCE, VOLUME VII, edited by William S. Coker, reviewed by Don Higginbotham; TACACHALE: ESSAYS ON THE INDIANS OF FLORIDA AND SOUTHEASTERN GEORGIA DURING THE HISTORIC PERIOD, edited by Jerald T. Milanich and Samuel Proctor, reviewed by John W. Griffin; THE TROUBLE OF IT Is, by David M. Newell, reviewed by Gloria Jahoda; THE YOUNG HAMILTON: A BIOGRAPHY, by James Thomas Flexner, reviewed by Aubrey C. Land; THE RISE AND FALL OF THE PLANTATION SOUTH, by Raimondo Luraghi, reviewed by Julia F. Smith; MILLEDGEVILLE: GEORGIA’S ANTEBELLUM CAPITAL, by James …

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Immigrants And Radicals In Tampa, Florida, George E. Pozzetta Dec 2021

Immigrants And Radicals In Tampa, Florida, George E. Pozzetta

Florida Historical Quarterly

The role that radical ideologies have played in the experience of America’s immigrant groups has been the subject of increasing scholarly attention. Historians are coming to realize that these philosophies often exerted a substantial influence on ethnic group development. This was particularly true of the manner in which immigrants interacted with the labor movement in America. That these developments have often been overlooked has been explained, in part, by a lack of documentary evidence available for use in charting the events, issues, and personalities of the radical world. In recent years, however, a growing volume of historical material has become …

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Rebellion In East Florida In 1795, Janice Borton Miller Dec 2021

Rebellion In East Florida In 1795, Janice Borton Miller

Florida Historical Quarterly

Soon after East Florida was returned to Spain by the British following the American Revolution, a governmental structure was established with headquarters in St. Augustine. The first governor of this second Spanish period, Don Vizente Manuel de Zespedes, carried out the complex process of transferring jurisdiction. Thus by 1790, when the second governor, Juan Nepomuceno de Quesada, arrived in the province most of the English settlers had emigrated and Spanish institutions-government, trade, church, and school-were operating. St. Augustine was a town of approximately 1,862 persons, of whom 450 were in the military and about 412 were slaves.

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University Of North Florida Nature Preserve Robert W. Loftin Nature Trails, University Of North Florida Dec 2021

University Of North Florida Nature Preserve Robert W. Loftin Nature Trails, University Of North Florida

Nature Trails Print

Informational pamphlet for UNF Nature Preserve, Robert W. Loftin Nature Trails.

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Federal Designation Of Unf Nature Trail Materials, University Of North Florida Dec 2021

Federal Designation Of Unf Nature Trail Materials, University Of North Florida

Nature Trails Print

Letters, articles and other papers about the UNF Nature Trails including being officially designated as a National Recreation Trail in the U.S. National Trails System.

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Surviving Interlocutory Appeals: Trial Lawyer Edition, Grace Jun Dec 2021

Surviving Interlocutory Appeals: Trial Lawyer Edition, Grace Jun

The Bridge: Interdisciplinary Perspectives on Legal & Social Policy

This presentation provides an overview of Supreme Court caselaw regarding qualified immunity and government officials’ right to interlocutory appeal from denials of qualified immunity, and provides a brief discussion of ways trial lawyers can overcome interlocutory appeals to provide their injured plaintiffs with an opportunity to be heard and vindicated at trial by a jury.

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Review Of Motivational Practices And Job Performance Of Staff In University Libraries, Wisdom Okereke Anyim Dec 2021

Review Of Motivational Practices And Job Performance Of Staff In University Libraries, Wisdom Okereke Anyim

Library Philosophy and Practice (e-journal)

Understanding the factors that motivate library staff helps to improve job performance and accelerate service delivery in the library. The paper revealed motivational methods that guarantee increasing productivity of staff, engagement and potential maximization. The study reviewed the concept of job performance, effect of motivation on job performance, motivational approaches, theories of motivation and job performance. Various training and development programmes as motivational tools were also identified. It was concluded that motivational practices should not be taken for granted as library staff tend to perform effectively when they are motivated by the management.

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What Does Social Entrepreneurship Mean To Change Agents In New Mexico? A Phenomenographic Approach To Understanding Social Entrepreneurship, Audriana Stark Dec 2021

What Does Social Entrepreneurship Mean To Change Agents In New Mexico? A Phenomenographic Approach To Understanding Social Entrepreneurship, Audriana Stark

Organization, Information and Learning Sciences ETDs

Social entrepreneurship has been identified as a solution to some of the world’s most pressing problems, including health, education, and environmental issues. Despite the rise in literature about social entrepreneurship, there is still a lack of understanding how place-based social entrepreneurship is being conceived and experienced by practitioners. Therefore, this study uses a phenomenographic approach to understand what social entrepreneurship means to change agents in New Mexico, a place characterized by social and economic challenges, as well as an abundance of natural and cultural resources. The findings revealed five distinct categories of description for social entrepreneurship including: Category 1. No …

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Legal Nature, Historical Developments Of Expertise And Comparative Analysis Of The Legislation Of Foreign Countries, Astanov Istam Rustamovich, Astanov Shuxrat Rustamovich Dec 2021

Legal Nature, Historical Developments Of Expertise And Comparative Analysis Of The Legislation Of Foreign Countries, Astanov Istam Rustamovich, Astanov Shuxrat Rustamovich

ProAcademy

This article is About expertise on criminal affairs is the separate give special status a type of the expertise, different carrying out research from the person possessing special knowledge. Expertise on criminal affairs differs from other types of expertise by that it is appointed and carried out according to strictly and precisely established Code of criminal procedure rather. The part second of article 153 Criminal Procedure Code of Moldova, devote interrogation the expert, consolidates norm on which it is forbidden to make interrogation before submission of the expert opinion and its studying. Fixing of such rule in part the second …

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Stop The Beat To See The Rhythm: Excitation-Contraction Uncoupling In Cardiac Research., Luther M Swift, Matthew W. Kay, Crystal M Ripplinger, Nikki Gillum Posnack Dec 2021

Stop The Beat To See The Rhythm: Excitation-Contraction Uncoupling In Cardiac Research., Luther M Swift, Matthew W. Kay, Crystal M Ripplinger, Nikki Gillum Posnack

Pediatrics Faculty Publications

No abstract provided.

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Do It By The Book - The Development And Manufacturing Of Books In The Middle Ages, Casey Cromp, Annaliese Croasdale, Emma Pilmer, Lauren Diciaula Dec 2021

Do It By The Book - The Development And Manufacturing Of Books In The Middle Ages, Casey Cromp, Annaliese Croasdale, Emma Pilmer, Lauren Diciaula

2021 Festschrift: The Interpolated Roman de Fauvel in Context

This paper discusses the book-making progress in the Middle Ages that was used across Europe. This process includes the making of paper, the making of the inks used, bookbinding, and how books were printed. Each is an important aspect of how early manuscripts were created. Without these processes, there would not be written documentation of early literature or music. This paper provides a deeper understanding of the work that was implemented into creating early books, and gives insight as to what the book-making process consisted of before the development of present-day technologies.

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Progression Of Indigenous Environmental Conflicts In The Up In Correlation To The National Development Of Indigenous Legal And Social Power, Katarina Rothhorn Dec 2021

Progression Of Indigenous Environmental Conflicts In The Up In Correlation To The National Development Of Indigenous Legal And Social Power, Katarina Rothhorn

Conspectus Borealis

This essay looks at how the reactions to environmental conflicts and activism pertaining to the Indigenous people in the Upper Peninsula of Michigan have changed over the years as Indigenous people have fought for recognition and legal status in the United States.

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Ketone Body Metabolism In The Ischemic Heart, Stephen C. Kolwicz Jr. Dec 2021

Ketone Body Metabolism In The Ischemic Heart, Stephen C. Kolwicz Jr.

Health Sciences Faculty Publications

Ketone bodies have been identified as an important, alternative fuel source in heart failure. In addition, the use of ketone bodies as a fuel source has been suggested to be a potential ergogenic aid for endurance exercise performance. These findings have certainly renewed interest in the use of ketogenic diets and exogenous supplementation in an effort to improve overall health and disease. However, given the prevalence of ischemic heart disease and myocardial infarctions, these strategies may not be ideal for individuals with coronary artery disease. Although research studies have clearly defined changes in fatty acid and glucose metabolism during ischemia …

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Sox10 Requirement For Melanoma Tumor Growth Is Due, In Part, To Immune-Mediated Effects, Sheera Rosenbaum, Manoela Tiago, Signe Caksa, Claudia Capparelli, Timothy J. Purwin, Gaurav Kumar, Mckenna Glasheen, Danielle Pomante, Daniel Kotas, I Chervoneva, A E Aplin Dec 2021

Sox10 Requirement For Melanoma Tumor Growth Is Due, In Part, To Immune-Mediated Effects, Sheera Rosenbaum, Manoela Tiago, Signe Caksa, Claudia Capparelli, Timothy J. Purwin, Gaurav Kumar, Mckenna Glasheen, Danielle Pomante, Daniel Kotas, I Chervoneva, A E Aplin

Department of Cancer Biology Faculty Papers

Developmental factors may regulate the expression of immune modulatory proteins in cancer, linking embryonic development and cancer cell immune evasion. This is particularly relevant in melanoma because immune checkpoint inhibitors are commonly used in the clinic. SRY-box transcription factor 10 (SOX10) mediates neural crest development and is required for melanoma cell growth. In this study, we investigate immune-related targets of SOX10 and observe positive regulation of herpesvirus entry mediator (HVEM) and carcinoembryonic-antigen cell-adhesion molecule 1 (CEACAM1). Sox10 knockout reduces tumor growth in vivo, and this effect is exacerbated in immune-competent models. Modulation of CEACAM1 expression but not HVEM elicits modest …

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Scorpionfish (Scorpaena Porcus) Neurocranium, Erin Porter, Cairone Reft, David Kerstetter Dec 2021

Scorpionfish (Scorpaena Porcus) Neurocranium, Erin Porter, Cairone Reft, David Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

Neurocranium preparation of a Scorpionfish (Scorpaena porcus) by Erin Porter and Cairone Reft for the Biology of Fishes course at Nova Southeastern University taught by Dr. Kerstetter.

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Public Intellectuals In The Age Of Viral Modernity: An Epat Collective Writing Project, Michael A. Peters, Petar Jandrić, Steve Fuller, Alexander J. Means, Sharon Rider, George Lăzăroiu, Sarah Hayes, Greg William Misiaszek, Marek Tesar, Peter Mclaren, Ronald Barnett Dec 2021

Public Intellectuals In The Age Of Viral Modernity: An Epat Collective Writing Project, Michael A. Peters, Petar Jandrić, Steve Fuller, Alexander J. Means, Sharon Rider, George Lăzăroiu, Sarah Hayes, Greg William Misiaszek, Marek Tesar, Peter Mclaren, Ronald Barnett

Education Faculty Articles and Research

No abstract provided.

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Covid-19 Newsletter (Vol. 98), Center For Disaster Medicine, New York Medical College Dec 2021

Covid-19 Newsletter (Vol. 98), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

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Gut Microbiota Composition And Predicted Microbial Metabolic Pathways Of Obesity Prone And Obesity Resistant Outbred Sprague-Dawley Cd Rats May Account For Differences In Their Phenotype, Diana N. Obanda, Michael J. Keenan, Ryan Page, Anne M. Raggio, Christopher M. Taylor, Brian D. Marx, Rhett W. Stout, Justin Guice, Meng Luo, David A. Welsh, Diana Coulon, Claudia Husseneder Dec 2021

Gut Microbiota Composition And Predicted Microbial Metabolic Pathways Of Obesity Prone And Obesity Resistant Outbred Sprague-Dawley Cd Rats May Account For Differences In Their Phenotype, Diana N. Obanda, Michael J. Keenan, Ryan Page, Anne M. Raggio, Christopher M. Taylor, Brian D. Marx, Rhett W. Stout, Justin Guice, Meng Luo, David A. Welsh, Diana Coulon, Claudia Husseneder

Faculty Publications

Like humans, outbred Sprague-Dawley CD rats exhibit a polygenic pattern of inheritance of the obese phenotype and not all individuals exposed to a high calorie intake develop obesity. We hypothesized that differences in gut microbiota composition account for phenotype differences between obese prone (OP) and obese resistant (OR) rats. We studied the gut microbiota composition of OPand OR rats after a high fat (HF) diet and how they respond to fermentation of resistant starch (RS). In phase 1 of the study 28 OP and 28 OR rats were fed a HF diet. In order to determine causal role of microbiota …

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Hypothalamic Steroid Receptor Coactivator-2 Regulates Adaptations To Fasting And Overnutrition, Yongjie Yang, Yanlin He, Hailan Liu, Wenjun Zhou, Chunmei Wang, Pingwen Xu, Xing Cai, Hesong Liu, Kaifan Yu, Zhou Pei, Ilirjana Hyseni, Makoto Fukuda, Qingchun Tong, Jianming Xu, Zheng Sun, Bert W. O'Malley, Yong Xu Dec 2021

Hypothalamic Steroid Receptor Coactivator-2 Regulates Adaptations To Fasting And Overnutrition, Yongjie Yang, Yanlin He, Hailan Liu, Wenjun Zhou, Chunmei Wang, Pingwen Xu, Xing Cai, Hesong Liu, Kaifan Yu, Zhou Pei, Ilirjana Hyseni, Makoto Fukuda, Qingchun Tong, Jianming Xu, Zheng Sun, Bert W. O'Malley, Yong Xu

Division of Basic Science Faculty Publications

The neuroendocrine system coordinates metabolic and behavioral adaptations to fasting, including reducing energy expenditure, promoting counterregulation, and suppressing satiation and anxiety to engage refeeding. Here, we show that steroid receptor coactivator-2 (SRC-2) in pro-opiomelanocortin (POMC) neurons is a key regulator of all these responses to fasting. POMC-specific deletion of SRC-2 enhances the basal excitability of POMC neurons; mutant mice fail to efficiently suppress energy expenditure during food deprivation. SRC-2 deficiency blunts electric responses of POMC neurons to glucose fluctuations, causing impaired counterregulation. When food becomes available, these mutant mice show insufficient refeeding associated with enhanced satiation and discoordination of anxiety …

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Baphia Macrocalyx Leaf Extract Attenuates Rotenone-Induced Toxicity In Drosophila Melanogaster Model Of Parkinson’S Disease, Flora Stephano Dec 2021

Baphia Macrocalyx Leaf Extract Attenuates Rotenone-Induced Toxicity In Drosophila Melanogaster Model Of Parkinson’S Disease, Flora Stephano

Journal of Humanities and Social Sciences

Parkinson’s disease (PD) is a motor disorder mostly affecting aged people, with not known standard therapy. The use of natural products is increasingly gaining attention for the treatment of different diseases. Baphia macrocalyx is a plant previously associated with antioxidant activities in in vitro studies. Thus, the aim of this study was to evaluate the ameliorative potential of methanolic leaf extract of Baphia macrocalyx (MEBM) on rotenone-triggered toxicity in Drosophila melanogaster. To this end, the study used a neurotoxin, rotenone, to induce PD in the fruit-fly to create a chemical PD in vivo model. Using biochemical, behavioural and molecular analyses, …

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