Digital Commons Network^™

Obesity And Asthma: A Focused Review, Rubabin Tooba, Tianshi David Wu

Faculty, Staff and Students Publications

No abstract provided.

Combination Tigit/Pd-1 Blockade Enhances The Efficacy Of Neoantigen Vaccines In A Model Of Pancreatic Cancer, Hui Peng, Lijin Li, Chong Zuo, Michael Y Chen, Xiuli Zhang, Nancy B Myers, Graham D Hogg, David G Denardo, S Peter Goedegebuure, William G Hawkins, William E Gillanders

2020-Current year OA Pubs

BACKGROUND: Cancer neoantigens are important targets of cancer immunotherapy and neoantigen vaccines are currently in development in pancreatic ductal adenocarcinoma (PDAC) and other cancer types. Immune regulatory mechanisms in pancreatic cancer may limit the efficacy of neoantigen vaccines. Targeting immune checkpoint signaling pathways in PDAC may improve the efficacy of neoantigen vaccines.

METHODS: We used KPC4580P, an established model of PDAC, to test whether neoantigen vaccines can generate therapeutic efficacy against PDAC. We focused on two immunogenic neoantigens associated with genetic alterations in the CAR12 and CDK12 genes. We tested a neoantigen vaccine comprised of two 20-mer synthetic long peptides …

Using Heidisongs Music As An Instructional Tool In The Elementary School Classroom: A Case Study, Leia Denise Jobe

Doctoral Dissertations and Projects

The purpose of this qualitative multiple case study is to understand how teachers use HeidiSongs music as an instructional tool in the elementary school classroom. HeidiSongs uses multisensory structured language education to teach by engaging multiple senses simultaneously to increase retention. The theories guiding this study include Gardner’s theory of multiple intelligences, which involves kinesthetic intelligences among other types of intelligences, and Krashen’s theory of second language acquisition. HeidiSongs uses both musical and kinesthetic activities to enhance literacy. The central research question focused on how teachers use HeidiSongs music as an instructional tool in the elementary school classroom. The sub-questions …

A Phenomenological Study Exploring The Client And Stylist Interaction As A Culturally Specific Form Of Coping With Stress For Black Women In The United States, Nicole Michelle Holden

Doctoral Dissertations and Projects

The purpose of this study is to describe the experience of Black women who visit the salon regularly in the United States. This study is constructed around the culturally intimate relationship of the stylist-client interaction in the Black community as a historical coping mechanism in which Black women utilize for stress and life challenges rather than seek professional mental health services. Although COVID-19 continues to mount a significant mortality rate and financial hardships, its disproportionate effects on communities of color will have lasting implications on their mental health. The need for mental health services has increased due to the mental …

Christian Devotional Meditation And Holistic Well Being, Raymond D. Paxton

Doctoral Dissertations and Projects

Holistic well-being is a concept that implies humans are multidimensional and require a broad approach to help them achieve life contentment and satisfaction. Spirituality, relationships, emotional functioning, and biology all play a part in achieving this life balance and satisfaction. Interpersonal neurobiology suggests that early life experiences can contribute to underdeveloped brain structures resulting in the diminished ability to form meaningful attachment relationships that help foster contentment as an adult. This ability to engage in positive and supportive relationships has impact on life and holistic well-being. Further, the inability to form close relationships, engage, and emotionally connect with others has …

Islet Cilia And Glucose Homeostasis, Isabella Melena, Jing W Hughes

2020-Current year OA Pubs

Diabetes is a growing pandemic affecting over ten percent of the U.S. population. Individuals with all types of diabetes exhibit glucose dysregulation due to altered function and coordination of pancreatic islets. Within the critical intercellular space in pancreatic islets, the primary cilium emerges as an important physical structure mediating cell-cell crosstalk and signal transduction. Many events leading to hormone secretion, including GPCR and second-messenger signaling, are spatiotemporally regulated at the level of the cilium. In this review, we summarize current knowledge of cilia action in islet hormone regulation and glucose homeostasis, focusing on newly implicated ciliary pathways that regulate insulin …

Use Of Leishmania Major Parasites Expressing A Recombinant Trypanosoma Cruzi Antigen As Live Vaccines Against Chagas Disease, Catherine W Cai, Anne O'Shea, Christopher S Eickhoff, Hongjie Guo, Warren G Lewis, Stephen M Beverley, Daniel F Hoft

2020-Current year OA Pubs

INTRODUCTION:

METHODS: We generated recombinant

RESULTS: We demonstrate that mice inoculated with these recombinant TS-expressing

DISCUSSION: Altogether, these data indicate that

Superior Status: Relational Obstacles In Law To Racial Justice And Lgbtq Equality, Osamudia James

Faculty Publications

Animus and discrimination are the two legal lenses through which in-equality is typically assessed and understood. Insufficient attention, however, is paid to the role of status in animating inequality, even in landmark cases thought to be equality-promoting. More than an animating force between intractable po-litical conflicts, status also informs the development of equality law in the United States. When courts, advocates, and policymakers affirm, ignore, miss, or con-cede to status hierarchies instead of dismantling them, those groups that perceive a decrease in their status relative to others will only use “equality-promoting” doctrine to rebalance status hierarchy in their favor. Public …

Policing The Polity, Eisha Jain

Faculty Publications

The era of Chinese Exclusion left a legacy of race-based deportation. Yet it also had an impact that reached well beyond removal. In a seminal decision, the U.S. Supreme Court upheld a law that required people of “Chinese descent” living in the United States to display a certificate of residence on demand or risk arrest, detention, and possible deportation. Immigration control provided the stated rationale for singling out a particular group of U.S. residents and subjecting them to race-based domestic policing. By treating these policing practices as part and parcel of the process of deportation, the Court obscured the full …

Automated Legal Guidance At Federal Agencies, Joshua D. Blank, Leigh Z. Osofsky

Faculty Publications

When individuals have questions about Federal benefits, services, and legal rules, they are increasingly seeking help from government chatbots, virtual assistants, and other automated tools. Current forms of automated legal guidance platforms include the U.S. Citizenship and Immigration Services’s “Emma,” the U.S. Department of Education’s “Aidan,” and the Internal Revenue Service’s “Interactive Tax Assistant.” Most scholars who have studied artificial intelligence and Federal government agencies have not focused on the government’s use of technology to offer guidance to the public. The absence of scholarly attention to automation as a means of communicating government guidance is an important gap in the …

Automated Video Interviewing As The New Phrenology, Ifeoma Ajunwa

Faculty Publications

This Article deploys the new business practice of automated video interviewing as a case study to illuminate the limitations of traditional employment antidiscrimination laws. Employment antidiscrimination laws are inadequate to address the unlawful discrimination attributable to emerging workplace technologies which gatekeep employment opportunities. The Article maintains that the practice of automated video interviewing is based on shaky or unproven social scientific principles that disproportionately impact racial minorities. In this way, the practice of automated video interviewing is analogous to the pseudoscience of phrenology, which enabled societal and economic exclusion through the legitimization of eugenicist and racist attitudes. After parsing the …

White Injury And Innocence: On The Legal Future Of Antiracism Education, Osamudia James

Faculty Publications

In the wake of the “racial reckoning” of 2020, antiracism education attracted intense attention and prompted renewed educator commitments to teach more explicitly about the function, operation, and harm of racism in the United States. The increased visibility of antiracism education engendered sustained critique and opposition, resulting in executive orders prohibiting its adoption in the federal government, the introduction or adoption of over sixty state-level bills attempting to control how race is taught in schools, and a round of lawsuits challenging antiracism education as racially discriminatory. Because antiracism so directly runs afoul of norms underlying American antidiscrimination law, including anticlassification, …

Cgas-Sting Pathway Targeted Therapies And Their Applications In The Treatment Of High-Grade Glioma, Shashwat Tripathi, Hinda Najem, Akanksha Sanjay Mahajan, Peng Zhang, Justin T Low, Alexander H Stegh, Michael A Curran, David M Ashley, Charles David James, Amy B Heimberger

2020-Current year OA Pubs

Median survival of patients with glioblastoma (GBM) treated with standard of care which consists of maximal safe resection of the contrast-enhancing portion of the tumor followed by radiation therapy with concomitant adjuvant temozolomide (TMZ) remains 15 months. The tumor microenvironment (TME) is known to contain immune suppressive myeloid cells with minimal effector T cell infiltration. Stimulator of interferon genes (STING) is an important activator of immune response and results in production of Type 1 interferon and antigen presentation by myeloid cells. This review will discuss important developments in STING agonists, potential biomarkers for STING response, and new combinatorial therapeutic approaches …

Nonmarriage And Choice In South Africa And The United States, Holning Lau, Suzanne A. Kim

Faculty Publications

In this Article, we examine three insights about free choice that emerge from studying the development of South Africa’s law of nonmarriage. First, South African jurisprudence advances understandings of nonmarriage as a valid choice. Unlike U.S. jurisprudence, which has been accused of overprivileging marriage and demeaning nonmarriage, South African jurisprudence draws attention to people’s legitimate reasons for choosing not to marry and the dignity interests attached to that choice. South African law helps to broaden the imagination of what is possible when nonmarriage is respected as a valid choice.

Second, South African jurisprudence illuminates the fact that the choice whether …

Postnatal Osterix But Not Dmp1 Lineage Cells Significantly Contribute To Intramembranous Ossification In Three Preclinical Models Of Bone Injury, Evan G Buettmann, Susumu Yoneda, Pei Hu, Jennifer A Mckenzie, Matthew J Silva

2020-Current year OA Pubs

Murine models of long-bone fracture, stress fracture, and cortical defect are used to discern the cellular and molecular mediators of intramembranous and endochondral bone healing. Previous work has shown that Osterix (Osx

Endogenous Opioid Systems Alterations In Pain And Opioid Use Disorder, Jessica A Higginbotham, Tamara Markovic, Nicolas Massaly, Jose A Morón

2020-Current year OA Pubs

Decades of research advances have established a central role for endogenous opioid systems in regulating reward processing, mood, motivation, learning and memory, gastrointestinal function, and pain relief. Endogenous opioid systems are present ubiquitously throughout the central and peripheral nervous system. They are composed of four families, namely the μ (MOPR), κ (KOPR), δ (DOPR), and nociceptin/orphanin FQ (NOPR) opioid receptors systems. These receptors signal through the action of their endogenous opioid peptides β-endorphins, dynorphins, enkephalins, and nociceptins, respectfully, to maintain homeostasis under normal physiological states. Due to their prominent role in pain regulation, exogenous opioids-primarily targeting the MOPR, have been …

Social Justice As Desistance: Rethinking Approaches To Gender Violence, Deborah M. Weissman

Faculty Publications

Part I of this Article describes most domestic violence intervention programs (DVIPs) as they currently function with regard to gender violence. It critiques the structure of these programs, their close partnership with criminal legal system actors, perceived deficiencies, and it identifies missed opportunities to provide meaningful intervention strategies with those who have harmed. It demonstrates the ways that laws, regulations, and policies governing DVIPs constrain most programs from moving beyond established practices informed by punitive approaches to address the structural conditions that situate gender violence within a political economic framework.

Part II begins with a brief overview of the research …

A Taxonomy Of Professional Identity Formation, Harmony Decosimo

Faculty Publications

Following the ABA’s mandate requiring law schools provide students with opportunities for “professional identity formation,” this article seeks to clarify and loosely taxonomize the field of professional identity formation as it is being advanced by scholars and employed in U.S. law schools. By organizing this varied and somewhat muddled field into three dominant types or approaches and examining the primary and sometimes hidden goals of each, this article raises for review the potential pitfalls in this project, including the possibility of coercion, impotence, or waste. Ultimately, this article aims to pave the way for more constructive, transparent, and fruitful dialogue …

Systemically Important Platforms, Caleb N. Griffin

Faculty Publications

Regulating Big Tech is now a matter of intense public debate. We ask how well Big Tech companies fulfill their role as gatekeepers of the public square. We ponder whether their dominant market positions merit an antitrust response. We assess their culpability and complicity in spreading online misinformation and hate. However, in the many normative debates over how Big Tech should use its power, the source of that power remains largely unexamined.

Big Tech, like Big Tobacco before it, is an industry founded on addiction. Although typically “free” to use, the world’s largest digital platforms exploit users’ dopamine pathways to …

Judges And Mass Incarceration, Carissa Byrne Hessick

Faculty Publications

This Article argues that judges—long overlooked in contemporary explanations of mass incarceration—have played a central role both through affirmative decisions that increased punishment and through failures to act as a check on prosecutorial power. It traces how judicial choices such as imposing the trial penalty, deferring to sentencing guidelines, allowing coercive plea bargaining, expanding pretrial detention, and adopting narrow or delayed statutory interpretations have structurally reshaped the criminal justice system to favor conviction and incarceration. The Article then proposes practical steps trial judges could implement immediately to reverse these trends, including reducing reliance on pretrial detention, eliminating the trial penalty, …

Enhancing Children's Achievement In Basic Science Using Library Electronic Books: A Case Of Simple Repeated Evaluation, Christian Ugwuanyi Phd

Library Philosophy and Practice (e-journal)

The 21^st century classrooms demand a lot from both the teachers and the learners due to the technological developments and demands in teaching and learning. These days, most parents buy their children (smart/android phones, tablets, or laptops without knowing the educational benefits of these gadgets in accessing online learning materials. The 21^st century technology has made the use of e-books very beneficial to the teaming population of learners who have access to the internet, but it is worrisome that there is a dearth of research on such issues in the Nigerian context. Thus, this research examined the effect …

Assessment Of Electronic Learning Usage In The Upper Basic Education French Language Curriculum: Implication For Evaluation Of Library And Information Science Resources, Kenneth Oma Eze Phd, Ekwutosi Monica Nnadi Phd, Christian Sunday Ugwuanyi Phd

Library Philosophy and Practice (e-journal)

People who work in a library and information science unit are passionate about making a positive difference in the world. Librarians are the people who work in this field, and their job is to bridge the gaps that exist between people, information, and technology. In today’s classroom instructional delivery, the use of electronic learning (e-learning) has become imperative. Thus, the study investigated the extent of implementation of e-learning in the upper basic education French language curriculum and its implication for the evaluation of Library and Information Science Resources. A sample of 370 students participated in the study. A 15–item questionnaire …

The Use Of Personal Digital Archiving For Effective Learning During Pandemic Covid-19, Naufal Ahmad Rijalul Alam

Library Philosophy and Practice (e-journal)

The Covid 19 pandemic that ravaged the world, particularly Indonesia, had a negative impact on aspects of learning, particularly for children aged three to six years in early childhood education. The implementation of distance learning disrupted the face-to-face learning model, which was supposed to be the primary medium for increasing children's knowledge and interest. In this regard, the role of parents is critical in ensuring that learning at home is effective and enjoyable. This study explores the using personal digital archiving (PDA) conducted by parents for effective learning during pandemic covid-19. By using a case study, this qualitative research took …

Library Use For Agricultural Research By Undergraduate Students Of The Faculty Of Agriculture, Forestry And Wildlife Resources Management, University Of Calabar, Nigeria, Friday O. Idiku, Oliver Effiong Ntui, Dorathy Aje Iyamah, Love Eyo Abu, Dorcas Okaja Ochang

Library Philosophy and Practice (e-journal)

The study investigated the use of the University of Calabar library for agricultural research by students of the Faculty of Agriculture, Forestry and Wildlife Resources Management. The general objective of the study was to determine the use of the University of Calabar library for agricultural research by students of the Faculty of Agriculture, Forestry and Wildlife Resources Management. The specific objectives include to identify the number of students of the Faculty of Agriculture who registered with the University of Calabar library for the 2020/2021 academic session, identify the purpose of library use by students, assess the material and electronic resources …

School Library Resources For Inclusive Online English Language Learning: Teachers’ Perspectives About Differentiating Instruction In The Context Of English As Second Language, Angela Eze, Charity N. Onyishi

Library Philosophy and Practice (e-journal)

Abstract

In an inclusive education setting, learners with and without disabilities are guided to study in the same classrooms with adaptable facilities and equipments. With this arrangement in place, assistive technology becomes an absolute requirement, and the school library is a medium for providing and using inclusive resources. In the current education system where online learning is speedily overtaking face-to-face learning modalities, school Library resources are indispensable for the effective inclusion of all learners through differentiated instruction. Such is critically essential for English language learning, especially in Nigeria, where English is learned as a Second Language. However, little is known …

Collection Development Policy For E-Resources, Santana Baruah, Dr. Anupam Chanda

Library Philosophy and Practice (e-journal)

Collection development is a most important process of a library. This process increases the reading materials of the library for the satisfaction of the reader approach. Collection development policy acts as a guide for selecting library materials. It helps to maintain library cooperation and communication between library staff. This process increases the reading materials of the library for the satisfaction of the reader approach. Collection development policies are written statements of goals and evaluative parameters to guide decision-making when adding material to a library collection. A large number of e-resources collection has become a challenge to libraries as a lot …

Computing Technologies And Paperless Classroom In Library Schools In Rivers State, Anthonia Eghieso Omehia, Onyema Nsirim

Library Philosophy and Practice (e-journal)

Paper has been a convenience medium of communicating information, accessing information, as well as delivering and receiving lecture. However, as time changes, the mode of communication and instructional methodology takes a paradigm shift. This has resulted to the use of paperless classroom. Paperless classroom is the use of computing and communication technologies to replace the traditional method of teaching and learning in the classroom. It offers speed and ease of using electronic means in delivering lecture to a large number of students which is cost effective to students and lecturers. Consequently, schools are using computing technologies to ease the cost …

International Law: A Roadmap For Foreign Official Immunity In U.S. Courts, Chimène I. Keitner

The Judges' Book

No abstract provided.

Machine Learning Techniques For Network Analysis, Irfan Lateef

Dissertations

The network's size and the traffic on it are both increasing exponentially, making it difficult to look at its behavior holistically and address challenges by looking at link level behavior. It is possible that there are casual relationships between links of a network that are not directly connected and which may not be obvious to observe. The goal of this dissertation is to study and characterize the behavior of the entire network by using eigensubspace based techniques and apply them to network traffic engineering applications.

A new method that uses the joint time-frequency interpretation of eigensubspace representation for network statistics …

Ecological Restoration Parks In Xi’An, China: An Evolving Type, Han Yan

Dissertations

This dissertation examines four urban ecological restoration projects used as public spaces in the city of Xi'an, China. The overall goal is to understand the social and ecological implications of the site features at both design and planning scale and define what is ecological restoration in China's urban context. The result of the research shows that the top-down planning initiatives approach for establishing ecological restoration sites in urban areas that meet the need for more public open space in addition to restoring healthy urban ecological systems is very different from the definition of what is traditionally understood as "ecological restoration". …