Digital Commons Network^™

Uncovering The Mechanism Of Reep2-Mediated Emt-Driven Membrane Trafficking In Lung Adenocarcinoma, Kevin Fulp

Theses and Dissertations--Toxicology and Cancer Biology

Membrane trafficking is frequently disrupted during cancer progression, and the underlying mechanisms remain largely unknown. Currently, no effective drugs target dysregulated membrane trafficking for cancer treatment. Recent evidence has demonstrated that epithelial-to-mesenchymal transition (EMT) in lung adenocarcinoma (LUAD) employs a membrane trafficking program to coordinate cancer cell invasion and immunosuppression. To further dissect the pro-tumorigenic membrane trafficking program, we initiated an in vivo CRISPRi screen to assess more than 2,000 membrane trafficking-related genes in a syngeneic mouse LUAD model. We identified REEP2, an endoplasmic reticulum (ER) shaping protein, as a novel regulator of EMT-driven membrane trafficking. High REEP2 expression is …

Reep2-Driven Pro-Metastatic Secretion Promotes Lung Cancer Progression, Oluwafunminiyi E. Obaleye

Theses and Dissertations--Toxicology and Cancer Biology

Membrane trafficking plays a critical role in cellular function and is frequently dysregulated in cancer to promote metastasis. In lung adenocarcinoma (LUAD), the epithelial-to-mesenchymal transition (EMT) activating transcription factor, ZEB1, drives a pro-metastatic membrane trafficking program; however, the underlying molecular mechanisms remain poorly understood. Using a CRISPR interference (CRISPRi) in vivo screen of 2,099 membrane trafficking regulators in a syngeneic mouse model of EMT-driven LUAD, we identified REEP2 — an endoplasmic reticulum (ER) shaping protein — as a critical regulator of tumor progression. REEP2 mRNA expression correlates with poor prognosis, EMT signatures, and an immunosuppressive tumor microenvironment in LUAD patients. …

2026 Lynn University Student Research Symposium, Lynn University

Student Research Symposium Programs

The 2026 Lynn University Student Research Symposium was held Friday, April 24, 2026 on the 2nd floor of the Eugene M. and Christine E. Lynn Library.

Unlucky Chapter 13, Lawrence Ponoroff

Missouri Law Review

As a social program for individual debtors dealing with financial upheaval, Chapter 13 of the federal Bankruptcy Code is a failure and has been from its inception nearly 90 years ago. It is overly complex, internally inconsistent, and the product of congressional schizophrenia. There is no eagerness to fix it and no interest in eliminating it, which are both suggestions I have offered in the past. And so, with two strikes against me, I’ve decided to take my third and final swing. Using one of the most recent subjects of judicial disagreement over the proper application of the statute as …

Counterman V. Colorado: Is Recklessness An Emerging Threat To Hate Speech Impunity?, Jason Zenor

Western New England Law Review

Many people believe that the First Amendment provides too much protection for harmful speech, as the legal system struggles to balance these free speech protections with the harms amplified by the digital era. In cases involving online threats, the U.S. Supreme Court’s true threats doctrine made prosecution difficult, as the government had to show beyond a reasonable doubt that the speaker intended to threaten a specific target. Then, in 2023, the U.S. Supreme Court lowered the constitutional bar for true threats. The Court held that the government only had to show that the speaker was reckless and understood that the …

Justice David Souter And His Care For First Amendment Freedoms, David L. Hudson Jr.

Western New England Law Review

Justice David Souter left a remarkable legacy during his time on the U.S. Supreme Court. Nowhere was this more evident than in his sensitivity and solicitude for First Amendment freedoms. This essay examines Justice Souter’s First Amendment legacy primarily through his jurisprudence in three areas: (1) the secondary effects doctrine; (2) public employee free-speech cases; and (3) Establishment Clause opinions.

Granting The High Seas Personhood And Quasi-State Status, Jennifer Bass

Western New England Law Review

The Agreement on Marine Biological Diversity of Areas Beyond National Jurisdiction has now secured sufficient ratifications to enter into force. The enforcement mechanisms of the treaty could be strengthened to better protect biodiversity by granting the high seas personhood and providing the high seas quasi-statehood. The enforcement mechanism would be through the United Nations Convention on the Law of the Sea’s (UNCLOS) International Tribunal of the Sea. Specifically, enforcement could be strengthened by working with other entities such as Regional Fisheries Management Organizations (RFMOs), the Fish Stocks Agreement, and the Convention on International Trade in Endangered Species of Wild Fauna …

Twelve Preludes, Sarah Miller-Ross

Graduate Theses/Dissertations

This set of 12 Preludes for solo piano draws inspiration from Chopin’s set of 24 Preludes for the same instrument, along with ideas from other composers and various genres to create a varied set in which each piece is centered around a note of the 12-note chromatic scale. The movements are titled based on the material that inspired them, the effect they create, or the special technique or limitation they used. A brief overview of inspirational material will be discussed, then each movement will be described through the lens of their compositional processes.

Corpus Meum, Mea Electio, Kara L. Coonrod

Graduate Theses/Dissertations

The right to bodily autonomy and reproductive freedom is something I hold very close to my heart. Women who did not wish to embrace motherhood, or who grew beyond the walls of the hearth and home, have been far more often persecuted than praised. Over the past two years, I have created artwork borrowing the visual and material language of the Catholic church (along with personally relevant folklore) to elevate my freedom of choice and bodily autonomy in the face of religiously driven political oppression. Using a less frequently referenced organ from my reproductive system to represent my struggle against …

Investigating The Effects Of Biodegradable And Non-Biodegradable Microplastics On Pea Plant (Pisum Sativum L.), Blessing Bisola Akinwande

Graduate Theses/Dissertations

Microplastics have emerged as a significant environmental concern, particularly in agricultural soils where they can interact with plants and potentially affect crop productivity and quality. This study investigated the effects of biodegradable and non-biodegradable microplastics on the growth, physiology, and elemental and metabolite composition of Pisum sativum L. (pea plants). Plants were cultivated under greenhouse conditions and exposed to 2% (w/w) compostable bioplastic (CBP) as a biodegradable microplastic and high-density polyethylene (HDPE) as a non-biodegradable microplastic. Plant growth and physiological parameters, including plant height, seed biomass, chlorophyll content, and lipid peroxidation, showed no significant differences between treatments and control, …

Back Burner, Olga Jocelyn Shute

Graduate Theses/Dissertations

As a first-generation Mexican American, I look for alternative sources of inspiration through spiritual practices and postcolonial artwork that predate American modern/contemporary art. People of color in the US are categorized by words like Latin X, first, second, or third generation, Mexican American, and so on. In searching for my own identity, I question the verbiage that places constrictions over my body, soul, and life experiences. Compared to its pre-declaration of the lands, the United States' 250-year history is rather short. Looking at a portion of my cultural heritage, I associate dogs, jewelry, and maize with tradition, power, and spiritual …

Lsu General Catalog 2026-2027, Louisiana State University And Agricultural And Mechanical College

LSU General Catalog

The LSU General Catalog describes all undergraduate and graduate departments and programs with degree requirements and courses offered for each one. The LSU General Catalog includes information on registration and financial aid as well as academic services offered to all students

Cyber Security Related To Agricultural Data Encryption Using Edge Computing Devices, Mohammad Ashik Alahe

Electronic Theses and Dissertations

Smart Agriculture increasingly relies on image-based sensing, edge computing, and artificial intelligence to support data-driven decision-making in modern farming systems. While these technologies improve productivity and resource efficiency, they also introduce significant cybersecurity risks, particularly agricultural images transmitted and processed in real-time on resource-constrained edge devices. Unauthorized access, data manipulation, and interception of image data can lead to incorrect agronomic decisions and severe economic consequences. Despite this risk, efficient and practical cybersecurity solutions for real-time agricultural imaging remain limited. This study addresses these challenges by developing and evaluating encryption-based cybersecurity frameworks tailored for real-time agricultural image protection on edge computing …

Accelerating The Discovery Of The Genetic And Molecular Bases Of Neurodevelopmental Disorders In Vivo Using Breasi-Crispr, Claire Mae Kittock

Dissertations and Theses

Many neurodevelopmental disorders occur due to perturbations in prenatal brain development. More genetic variants associated with neurodevelopmental disorders are continuously being identified. However, there is a lack of understanding of the pathogenic mechanisms. Here, we describe a novel application of the technique Breasi-CRISPR in modeling specific patient variants in the embryonic mouse brain. Breasi-CRISPR is a highly efficient system combining in utero electroporation with CRISPR-CAS9 genome editing. We hypothesized that Breasi-CRISPR would be sufficient at inserting patient analogous variants into endogenous loci to be used as a new paradigm for modeling neurodevelopmental disorders. We aimed to test if Breasi-CRISPR could …

A Poor Man's Cup: Chicory Experimentation In Nebraska,1890-1900, Rebecca Hupp

Dissertations and Theses

“A Poor Man’s Cup” explores how Nebraskans actively confronted the problems of the late nineteenth-century through experimenting with new commodities. Prolonged severe drought, economic depression, and poor grain prices created a troublesome situation that grew in complexity as U.S. markets expanded globally and agriculture underwent professionalization. Some lay farmers, like Gabriel and Philomena Bazelman of Holt County, did not wait for new methods to find their way through the experiment station system and instead conducted trials themselves. Through piecing together the story of Nebraska chicory production with periodicals from the 1890s, experiment station bulletins, and Congressional reports, this thesis demonstrates …

Virginia Commonwealth University Undergraduate Bulletin (2026), Virginia Commonwealth University

VCU Bulletins

Undergraduate bulletin for Virginia Commonwealth University for the academic year 2026-2027. It includes information on academic regulations, degree requirements, course offerings, faculty, academic calendar, and tuition and expenses for undergraduate programs

Beyond Interests And Ideas: Institutions And The Persistence Of Trade Protectionism In Brazil, Samo Sérgio Gonçalves Tosatti

West Chester University Graduate Theses, Dissertations, and Final Projects

Despite decades of economic reforms and growing international integration since the 1990s, Brazil has remained one of the most protectionist large economies in the global trading system. Tariff levels remain relatively high, the country maintains a limited network of trade agreements, and non-tariff barriers play a significant role in shaping market access. Existing explanations for this persistence have focused primarily on the influence of organized interests, particularly import-competing industries, and the enduring influence of developmentalist ideas rooted in Brazil’s import-substitution industrialization (ISI) legacy.

This dissertation argues that these explanations are incomplete without accounting for a third explanatory dimension: institutions. It …

The Disenchanted Grove: Postcolonial Modernity And The Decline Of Ri’I Bamboo Governance In Flores, Indonesia, Handoyo Handoyo, Puji Hastuti, Lukas Rumboko Wibowo, Budiyanto Dwi Prasetyo, Surati Surati, Kresno Agus Hendarto, Lila Juniyanti, Dewi Ratna Kurnia Sari, Desmiwati Desmiwati, Sanusi Sanusi, Ane Dwi Septina, Ramawati Ramawati

Forest and Society

This article explores the erosion of ri’i, a traditional ecological governance system practiced by the Ngadha people in Flores, Indonesia, in the face of modernization and postcolonial development. Based on long-term ethnographic fieldwork and interviews with cultural elders, ritual practitioners, and local authorities, the study documents how ri’i—a ritual-based regulatory system for bamboo resource management—has been progressively dismantled through the combined pressures of technocratic governance, land commodification, and shifts toward individualism. Empirically, the main drivers identified are state land certification (including Sertifikat Hak Milik, SHM) and village modernization campaigns, which reconfigure communal tenure and everyday governance practices. Once embedded …

Image-Derived 3d Hepatic Lobule Modeling Of Acetaminophen-Induced Hepatotoxicity, Rebecca Lauren Strauss

Selected Full-Text Master Theses 2021-

The liver’s highly structured vascular microarchitecture governs blood perfusion, metabolic zonation, and the spatial distribution of xenobiotic toxicity. Current computational models of hepatic drug metabolism often oversimplify this geometry, limiting their ability to capture realistic flow dynamics and cellular injury patterns. This study develops a multiscale computational framework to predict acetaminophen-induced hepatotoxicity using image-derived, three-dimensional hepatic lobule geometries. The model integrates computational fluid dynamics (CFD) with a mechanistic cellular injury module to simulate the interplay between perfusion, metabolism, and hepatocellular viability.

Realistic vascular reconstruction was achieved from histopathology liver slices, and the resulting geometry was meshed and solved using ANSYS …

The Fight For Public Rights On America’S Waterways, Mark Squillace

Colorado Environmental Law Journal

No abstract provided.

Fencing In A Technological Age: Utilizing Federal Regulatory Frameworks To Implement Virtual Fencing On Federal Public Land, Sam Johnson

Colorado Environmental Law Journal

No abstract provided.

A Précis Of Pfas Legislation In The Southwestern United States, Brenden Catt

Colorado Environmental Law Journal

No abstract provided.

People Over Paper: The Effectiveness Of International Agreements Under Treaty Capture, Eric Nicholson

Colorado Environmental Law Journal

No abstract provided.

Greening With Justice: Evaluating Denver’S Urban Green Space Policies Through An Environmental Justice Lens, Vicente Tapia

Colorado Environmental Law Journal

No abstract provided.

The Rhetoric And Memory Of Kumeprɛko, Benedicta Harford

Dissertations and Theses

This thesis examines the rhetoric of Kume Prɛko and asks what its major rhetorical appeals were both during 1994 and afterwards. First, I analyze major images and a speech from the protest and identify how it framed the VAT tax as an embodied, urgent issue for all citizens to resist. Then, I consider how Akufo-Addo silenced this "vernacular" memory in favor of his "official" narrative, drawing off the work of John Bodnar. Ultimately, this thesis shows how difficult it is for those in power to remember grassroots dissent in all their complexity but also how hard it is to completely …

The Intelligent Troglodyte’S Guide To Plato’S Republic, Douglas Drabkin

Philosophy Open Educational Resources

The Republic of Plato is one of the classic gateway texts into the study and practice of philosophy, and it is just the sort of book that has been able to arrest and redirect lives. How it has been able to do this, and whether or not it will be able to do this in your own case, is something you can only discover for yourself. The present guidebook aims to help a person get fairly deep, fairly quickly, into the project. It divides the dialogue into 96 sections and provides commentary on each section as well as questions for …

Asthma, Hailey Gaines

A with Honors Projects

Basic facts about asthma including signs and symptoms, tests, causes, preventative measures, and treatments.

Crispr-Cas9: Transforming Biomedical Technology Through Gene Editing, Zaina Issa

A with Honors Projects

The research paper describe the gene editing technique CRISPR-Cas9 and the implications of its use in different fields, including medicine and agriculture.

Storm Of Elysium: How The Most Afflicted Minds Of History And Fiction Made Legacies, Pierce Thompson

A with Honors Projects

Honors project involving historical/fictional characters and how they made history/created legacies with their afflictions/mental health conditions. Historical/book context will be provided, and the condition will be covered through psychiatric research for the particular character.

All She Ever Wanted Was The World: The Emergence Of Vocal Methodology, Pedagogy, And Opera Performance For Women In The Nineteenth Century, Emma Hawkinson

Dissertations and Theses

Important music methods books began to emerge in the 1750s with instrumental treatises for flute, piano, and violin. By the end of the nineteenth century, there was a multitude of treatises for a variety of instruments, including classical voice. This study investigates and analyzes the content of treatises from four individual women who performed, taught, and published vocal treatises in the nineteenth century: German Mathilde Marchesi (1821–1913), Italian Virginia Boccabadati (1828–1922), Spanish Matilde Esteban (1841–1915), and English American Clara Kathleen Rogers (1844–1931). These methods books are set in the historical context of the music industry before and during the nineteenth …