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Evolutionary Relationships Among Several Species From The Genus Cricotopus(Diptera: Chironomidae): What About Turkish Representatives Of This Genus?, Adi̇le Sari

Turkish Journal of Zoology

The genus Cricotopus (Diptera: Chironomidae) has a worldwide distribution and possesses a wide variation in ecology and habitat preference across its distribution. Identification of Cricotopus species and distinguishing them from the species of closely related genera (i.e. Orthocladius and Paratrichocladius) are generally difficult. This study aimed to investigate the evolutionary history of several Cricotopus species, with the main focus on C. bicinctus, C. flavocinctus, C. triannulatus, C. patens, C. intersectus, C. laricomalis, C. ornatus, C. reversus, and C. sylvestris from Turkey, using the mitochondrial cytochrome c oxidase subunit I (COI) gene. Molecular classifications of Turkish Cricotopus species were full compatible …

Hematological Status Of Avian Species Along A Metal Pollution Gradient At Sialkot, Pakistan, Ajmal Shehzad, Khalid Mahmood Anjum, Atif Yaqub, Muhammad Zubair Yousaf, Sarwr Allah Ditta, Junaid Naseer

Turkish Journal of Zoology

The concentration of metals and effects of these metals on hematological parameters were examined in avian species by using feathers and blood samples collected from different sites of Sialkot. The major reason for significant differences in hematological parameters and concentrations of metal contents between different species was the difference in feeding habitat. Metal concentrations in feathers and blood samples indicated that the chromium and lead were not found at a safe level. The results did not revealed a significant negative association between metal contents and hematological parameters but concluded that increased metal contents exert negative effects on hematological status especially …

Cover And Contents

Turkish Journal of Zoology

No abstract provided.

Egfr Blocker Lapatinib Inhibits The Synthesis Of Matrix Metalloproteinases From Synovial Fibroblasts, Demet Yalçin Kehri̇bar, Hakan Emmungi̇l, Neşe Başak Türkmen, Osman Çi̇ftçi̇, Emi̇ne Şalva, Meti̇n Özgen

Turkish Journal of Medical Sciences

Background/aim: Epidermal growth factor receptor (EGFR) family members and their associated ligands may be related to bone and joint destruction in rheumatoid arthritis. Matrix metalloproteinases are responsible for joint and bone tissue degradation. This study is intended to investigate the effect of epidermal growth factor receptor inhibition by lapatinib on the synthesis of matrix metalloproteinases in in vitro. Materials and methods: Synovial fibroblast cell culture was obtained from a patient with rheumatoid arthritis who underwent knee arthroplasty. Interleukin-1ß (IL-1ß) and tumor necrosis factor-∝ (TNF-∝) were added to the cell culture to stimulate synovial fibroblast cells and create an inflammatory character. …

Alpha-Lipoic Acid Prevents Atrial Electrical And Structural Remodeling Via Inhibition Of Nadph Oxidase In A Rabbit Rapid Atrial Pacing Model, Lei Chen, Wen Gao, Yameng Shao, Chenggang Li, Yuan Lu

Turkish Journal of Medical Sciences

Background/aim: Alpha-lipoic acid (ALA) is a natural compound, one of the natural antioxidants with high activity. In the NADPH oxidase family, NADPH oxidase 4 (NOX4) is an important subunit participating in the production of ROS. NADPH oxidase 2 (NOX2) can form active NADPH oxidase complexes when binding to several other subunits in the cytoplasm, and NOX2 is its major functional subunit. Rapid atrial pacing (RAP) model was constructed to study the effects of ALA on electrical and structural remodeling in rabbits. Materials and methods: Thirty rabbits were divided into SHAM group, RAP group and ALA+RAP group. Their right atriums were …

Evaluation Of Toxic Effects Of Dapagliflozin On Reproductive System In Diabetic Rats, Bahar Karaca, Tuğçe Boran, Ayça Karagöz Köroğlu, Feri̇ha Ercan, Gül Özhan

Turkish Journal of Medical Sciences

Background/aim: Dapagliflozin (DAPA), sodium-glucose cotransporter 2 (SGLT2) inhibitor, is an insulin-independent antidiabetic drug used to control hyperglycaemia by promoting glucose excretion from the kidney. Its adverse effects include orthostatic hypotension, dehydration and urinary tract and genital infections caused by glycosuria. DAPA is subjected to constant additional monitoring, as drugrelated adverse reactions are frequently updated in line with the results of case studies, clinical trials and in vivo studies. Some antidiabetic drugs have shown potential harmful effects on the male reproductive system; however, the effects of DAPA have not been sufficiently studied in this capacity. Aiming to fill this gap in …

Interrupted Processing Of Paired Somatosensory Stimuli In Short Interstimulus Intervals: Role Of Thalamo-Cortical Oscillations, Nermi̇n Tepe, Hürrem Evren Boran, Sali̇h Geduk, Ergi̇n Di̇leköz, İlkay Ulusoy, Hayrunni̇sa Bolay Belen

Turkish Journal of Medical Sciences

Background/aim: Discrimination of consecutive sensory stimuli is imperative for proper sensory perception and behavioral response. We aimed to investigate the emergence of paired somatosensory responses in relation to the interstimulus interval (ISI) change. Materials and methods: Paired stimulus with 35 ms, 50 ms, 80 ms, 140 ms, and 500 ms ISI was applied to the median nerve and evoked responses were recorded from the primary somatosensory cortex in rats. Early and late components of both responses were analyzed in different frequency bands. Results: The amplitudes were comparable for the 1st responses (S1), while the amplitude of the 2nd responses (S2), …

Effects Of Different Scar Types On Flap Viability In A Skin Flap Model: An Experimental Study, Ceyhun Uzun, Can İlker Demi̇r, Emrah Kağan Yaşar, Mehdi̇ Asadov, Murat Şahi̇n Alagöz, Esra Ci̇vri̇z, Çi̇ğdem Vural

Turkish Journal of Medical Sciences

Background/aim: The purpose of this study was to investigate the use of tissues with multiple traumas, scarred pedicles, and medial scarring as a flap. Materials and methods: Forty-eight rats were randomly divided into four equal groups. The modified McFarlane flap was chosen as the flap model. In Group 1 (control), a dorsal skin flap was elevated and then sutured back into original position. In the other groups, a two-phase procedure was used. In Group 2 (pedicle incision), scar tissue was created with a skin incision at the prospective pedicle site of the flap and then sutured to its original site. …

Androgenic Hormones In Crustacean Aquaculture: A Review, Muzaffer Mustafa Harlioğlu, Ardavan Farhadi̇

Turkish Journal of Zoology

Increased demands of the seafood market have led to the rapid growth in crustacean aquaculture production in various parts of the world. Therefore, an expansion in the knowledge of the reproductive biology of crustaceans has become more important. Hormones released from the androgenic gland (AG) in crustaceans are liable for both the separation of primary and secondary sexual features and reproductive behavior. AG removal in male crustaceans causes a transformation of the intersex animals towards the females and a degeneration of spermatids and reproductive organs. AG implantation and injection of AG extracts are common approaches for crustacean masculinization. In this …

Complementary Medicines Used In Ulcerative Colitis And Unintended Interactions With Cytochrome P450-Dependent Drug-Metabolizing Enzymes, Alaatti̇n Şen

Turkish Journal of Medical Sciences

Ulcerative colitis (UC) is an idiopathic, chronic inflammatory disease with multiple genetic and a variety of environmental risk factors. Although current drugs significantly aid in controlling the disease, many people have led to the application of complementary therapies due to the common belief that they are natural and safe, as well as due to the consideration of the side effect of current drugs. Curcumin, cannabinoids, wheatgrass, Boswellia, wormwood and Aloe vera are among the most commonly used complementary medicines in UC. However, these treatments may have adverse and toxic effects due to unintended interactions with drugs or drugmetabolizing enzymes such …

Circulating Mir-200c And Mir-33a May Be Used As Biomarkers For Predicting High Fructose Corn Syrup-Induced Fatty Liver And Vitamin D Supplementation-Related Liver Changes, Alpaslan Tanoğlu, Eylem Çağiltay, Esra Güzel Tanoğlu, Ayli̇n Gökhan, Cansin Şi̇ri̇n, Türker Çavuşoğlu, Recep Soner Yeşi̇lbaş

Turkish Journal of Medical Sciences

Background/aim: Nonalcoholic fatty liver is one of the most common forms of liver disease and role of microRNAs (miRNAs) on this illness is currently unclear. It was aimed to evaluate the predictive role of circulating miR-33a and mir-200c on high fructose corn syrup (HFCS)-induced fatty liver and vitamin D3 supplementation-related hepatic changes. Materials and methods: Twenty-four rats were randomized into three groups: sham (n = 8), experimental fatty liver group (n = 8), and fatty liver + vitamin D3 supplementation group (n = 8). In the treatment group, 10 µg/kg/week of vitamin D3 was given by orogastric tube weekly for …

Impact Of Atp Synthase/Coupling Factor 6 In Hypoxic Pulmonary Arterial Hypertension: An Experimental Rat Model, Nannan Li, Yugen Shi, Jie Yin, Li Sun, Qingshan Zhang, Shuai Bao, Juan Zhang, Youlei Li, Miaomiao Wang, Yanwei Zhang, Mei Xue, Lei Qi, Yan Li, Suhua Yan, Xiaolu Li

Turkish Journal of Medical Sciences

Background/aim: Hypoxia-induced pulmonary arterial hypertension (PAH) is characterized by prostacyclin (PGI2 ) disorder, which manifests in the same manner as in monocrotaline (MCT)-induced PAH. Endogenous PGI2 inhibitor coupling factor 6 (CF6) is involved in MCT-induced PAH. This study aimed to explore the presence or absence of a correlation between hypoxia-induced PAH and CF6. Materials and methods: This study was conducted between January 2019 and June 2020. A total of 135 male Wistar rats (aged 8 weeks and weighing 200?250 g) were randomly divided into five groups: (A) control, (B) 1 week of hypoxia, (C) 2 weeks of hypoxia, (D) 3 …

Dynamics Of A Western Anatolian Population Of Natrix Natrix And Natrix Tessellata(Serpentes: Natricidae), Yusuf Bayrakci, Di̇nçer Ayaz

Turkish Journal of Zoology

Due to their secretive nature, snakes are the most challenging animal group for monitoring. Nevertheless, population size estimates are indispensable to accurately determining conservation status and management strategies. We used passive integrated transponder (PIT) tags to track aquatic snakes Natrix natrix and Natrix tessellata in Lake Işıklı, Denizli province, Turkey. 304 N. natrix and 1563 N. tessellata specimens were captured and marked over the four-year sampling period. Of the marked individuals, 14 N. natrix and 97 N. tessellata were recaptured at least once. The three-year average population size was estimated at 1940 ± 1055 for N. natrix, and 10,146 ± …

Comparison Of Anakinra And Tocilizumab In Management Of Severe Covid-19: A Retrospective Cohort Study, Orhan Küçükşahi̇n, Abdulsamet Erden, Özlem Karakaş, Serdar Can Güven, Berkan Armağan, Enes Seyda Şahi̇ner, Osman İnan, Ali̇ Can Kurti̇pek, Emi̇n Gemci̇oğlu, Selma Karaahmetoğlu, Sema Turan, Seval İzdeş, Deni̇z Erdem, Adalet Aypak, Müge Ayhan

Turkish Journal of Medical Sciences

Background/aim: Studies regarding effectiveness of anakinra and tocilizumab treatments in coronavirus disease 2019 (COVID-19) have contradictory results. Furthermore, there is scarce comparative data regarding superiority of any agent. To further elucidate any superiority between these two agents, we retrospectively investigated and compared outcomes in hospitalized COVID-19 patients of our inpatient cohort who received anakinra or tocilizumab. Materials and methods: This study was designed as a single-center, retrospective, cross-sectional cohort study. Hospitalized patients with confirmed diagnosis of COVID-19 who had Brescia-COVID respiratory severity scale score ?3 and hyperinflammation (defined as elevation of C reactive protein ?50 g/L or ferritin ?700 ng/mL) …

What Is The Protective Effect Of Preischemic Kisspeptin-10 Administration Against Ischemia/Reperfusion Injury Of Striatum On Mice?, Hati̇ce Akkaya, Engi̇n Sümer, Seli̇m Kutlu, Hati̇ce Solak, Bayram Yilmaz

Turkish Journal of Medical Sciences

Background/aim: Kisspeptin is a neuropeptide with a primary role on the onset of puberty and has beneficial effects on ischemia/ reperfusion (I/R) injury. In this study, we aimed to investigate the effect of kisspeptin administration on striatal I/R injury in mice. Material and methods: Forty adult C57/BL6 mice were randomly divided into four groups: Sham, Kisspeptin, I/R, and I/R + Kisspeptin groups. The groups were administered with either physiological saline (Sham and I/R groups) or kisspeptin (Kisspeptin and I/R + Kisspeptin groups) intraperitoneally 40 min before the operation. A microdialysis probe was placed in the right striatum according to stereotaxic …

The Relationship Between Hidradenitis Suppurativa And Irritable Bowel Syndrome: A Cross-Sectional Study, Abdullah Demi̇rbaş, Ömer Faruk Elmas, Hedi̇ye Eker, Gözde Ulutaş Demi̇rbaş, Recep Dursun, Mustafa Atasoy, Ümi̇t Türsen, Torello Lotti̇

Turkish Journal of Medical Sciences

Background/aim: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder in which one experiences abdominal pain, tension, cramping, bloating, and changes in the form and frequency of defecation, without an underlying organic disease. Many skin diseases have been reported to be more common in people with functional bowel disease. To our knowledge, however, no previous study investigated the potential relationship between hidradenitis suppurativa (HS) and IBS. In this study, we aimed to examine the potential association between IBS and HS. Materials and methods: Patients with HS and healthy subjects were enrolled in this cross-sectional study. All participants were assessed for …

Investigation Of The Expression Levels Of Cdh1, Fhit, Pten, And Ttpal Genes In Colorectal Tumors, Evri̇m Suna Arikan Söylemez, Zafer Söylemez, Murat Çi̇lekar, Yüksel Arikan, Çi̇ğdem Tokyol, İbrahi̇m Hali̇l Kenger, Mustafa Solak

Turkish Journal of Medical Sciences

Background/aim: The main aim of the study is to assess expression levels of CDH1, FHIT, PTEN, and TTPAL genes in tumors and peripheral bloods of colorectal cancer patients in staged I-IV. Materials and methods: Gene expression analysis of related genes were performed for tumor tissues and peripheral blood samples of 51 colorectal cancer patients and colon tissues and blood samples of 5 healthy individuals. The real-time-PCR reaction method was used for the analysis. Results: Alteration of mRNA levels of related genes in tumor tissues of colorectal cancer cases was determined compared to control tissues. GAPDH and TBP were used for …

Developing The Nausea And Vomiting Thermometer Scale In Children With Cancer, Asli Akdeni̇z Kudubeş, Murat Bektaş

Turkish Journal of Medical Sciences

Background/aim: This study aimed to develop the Nausea and Vomiting Thermometer Scale (NVTS) in children with cancer. Materials and methods: This methodological study was conducted on 250 children with cancer at the research and training university hospital in Turkey between September 2019 and January 2020. The t-test, the ROC analysis, the Diagnostic index, and the Youden index were used for determining the scale of the cutting point. The regression analysis, the intra-class correlation coefficient, and the Bland- Altman analysis were used for the data analysis. Results: The scale-level content validity index was .94, which was coherent. As a result of …

Utility Of Etco2 To Predict Hemorrhagic Shock In Multiple Trauma Patients, Gülşen Öztürk Örmeci̇, Özlem Yi̇ği̇t, Oktay Eray

Turkish Journal of Medical Sciences

Background/aim: For identifying hemorrhagic shock in trauma patients, some objective data are needed. The use of base excess (BE) and lactate values have been originated. In this study, it was aimed to determine the usability of end tidal carbon dioxide (ETCO2) in patients with multiple trauma for recognizing hemorrhagic shock. Materials and methods: Patients who were admitted to the emergency department between June 2019 and February 2020 with high- energy multiple trauma were included in the study. ETCO2 and BE values were measured. Correlation coefficients were calculated to determine correlations between ETCO2 and BE levels. Results: One hundred and twenty-two …

Factors That Affect Placental Retinol Transfer In Preterm Infants And Mothers With Retinoldeficiency, Kadi̇r Şerafetti̇n Tekgündüz, Di̇lara Di̇lek, Mustafa Kara, Nuri̇nni̇sa Öztürk, Si̇bel Ejder Tekgündüz

Turkish Journal of Medical Sciences

Background/aim: The retinol level and retinol delivery to the placenta may vary depending on various factors involving the mother and newborn. The present study evaluates the factors affecting retinol levels in newborns and the transplacental retinol passage in preterm newborns. Materials and methods: In this prospective cohort study, the retinol and retinol binding protein (RBP) in the umbilical cord blood of 44 preterm infants with a gestation age of

Circular Rna Circprmt5 Is Upregulated In Breast Cancer And Is Required For Cellproliferation And Migration, Xiaofeng Li, Dairong Zhang, Zuxi Feng, Xiangjing Xu, Jihong Zhang, Aiping Yu, Li Zhu, Jie Xiao, Junhua Du, Min Chen

Turkish Journal of Medical Sciences

Background/aim: To evaluate the role of cyclic protein arginine methyltransferase 5 (circPRMT5) in the occurrence and development of breast cancer (BC). Materials and methods: A total of 90 BC patients who underwent radical mastectomy and 40 age-matched healthy female controls were recruited in the Second People's Hospital of China Three Gorges University, Yichang Second People's Hospital from 2017 to 2020. Quantitative reverse transcription polymerase chain reaction (RT-qPCR) was used to detect the expression levels of circPRMT5 in BC tissues, serum, normal breast cell line (MCF-10A), and BC cell line (T47D, MCF-7, BT549, Hs-578T, and MDA-MB-231, MDAMB-468). The associations between circPRMT5 …

Clinical And Imaging Findings Of Patients Diagnosed With Adenovirus-Positivepneumonia During 2015-2019 In Shanghai, China, Chunrong Huang, Dong Wei, Yahui Liu, Guo Chao Shi

Turkish Journal of Medical Sciences

Background/aim: This study was to describe the clinical characteristics, chest CT image findings, and potential role of T cells immunity in adenovirus positive pneumonia. Materials/methods: In this retrospective study, medical records of 53 adult Adv+ patients who were admitted to the Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, from May 2015 to August 2019 were included. The presence of adenovirus and other respiratory viruses was detected using polymerase chain reaction of throat swabs samples. Clinical features and chest computed tomography (CT) findings were compared between patients with Adv+ pneumonia and Adv+ non-pneumonia. Results: The top 3 most commonly …

Tp-E Interval, Tp-E/Qt, And Tp-E/Qtc Ratios In Patients With Primaryhyperparathyroidism And Their Relationship With Cardiac Arrhythmic Events, Yücel Yilmaz, Şaban Keleşoğlu, Ferhat Gökay, Yasi̇n Şi̇mşek

Turkish Journal of Medical Sciences

Background/aim: Primary hyperparathyroidism (PHPT) is an endocrine disorder characterized by hypercalcemia caused by excessive parathyroid hormone (PTH) secretion from the parathyroid gland. PHPT was previously shown to increase cardiac arrhythmias. Besides, new indices, such as the Tpeak-Tend (Tp-e) interval, Tp-e interval/QT interval (Tp-e/QT) ratio, and Tp-e interval/corrected QT interval (Tp-e/QTc) ratio may be associated with ventricular arrhythmias and sudden cardiac death. Therefore, we aimed to investigate the relationship between PHPT and the changes to Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio. Materials and methods: We carried out the study with 41 patients with PHPT and 40 control subjects. We calculated …

The Impact Of Bone Marrow-Derived Mesenchymal Stem Cells On Experimental Testiculartorsion In Rats, Ahmet Ertürk, Sabri̇ Demi̇r, Yasemi̇n Dere Günal, Mehmet Zengi̇n, Mi̇yase Çinar, Di̇nçer Yildiz, Si̇yami̇ Karahan, Emrah Şenel

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to investigate the healing effects of bone marrow-derived mesenchymal stem cells (BMMSCs) on experimental testicular torsion in rats. Materials and methods: Three groups consisting of 10 Wistar albino rats were created. In Group I, the left testicle was explored and relocated in the scrotum without any attempt to modify it. In Group II, the left testicle underwent torsion for three h and then was detorsed and relocated. In Group III, in addition to torsion and detorsion, BM-MSCs were administered intratesticularly. The rats were sacrificed on the seventh day, and the healing status of …

Irisin Relaxes Rat Thoracic Aorta Through Inhibiting Signaling Pathways Implicatingprotein Kinase C, Sadetti̇n Demi̇rel, Serdar Şahi̇ntürk, Naci̇ye İşbi̇l, Fadil Özyener

Turkish Journal of Medical Sciences

Background/aim: Irisin, a newly identified exercise-derived myokine, has been found involved in a peripheral vasodilator effect. However, little is known regarding the potential vascular activity of irisin, and the mechanisms underlying its effects on vascular smooth muscle have not been fully elucidated. This study was aimed to investigate the effects of irisin on vascular smooth muscle contractility in rat thoracic aorta, and the hypothesis that protein kinase C (PKC) may have a role in these effects. Materials and methods: Isometric contraction-relaxation responses of thoracic aorta rings were measured with an isolated organ bath model. The steady contraction was induced with …

Impact Of Supply Chain Integration On Halal Food Supply Chain Integrity And Food Quality Performance, Mohd Helmi Ali, Mohammad Iranmanesh, Kim Hua Tan, Suhaiza Zailani, Nor Asiah Omar

Research outputs 2014 to 2021

Purpose: The current complex halal food supply chain (SC) has caused food scandals, which have illustrated the weakness of multiple food quality standards and certification and audits in ensuring food safety. Drawn on the resource-based view (RBV) theory, the purpose of this study is to explore the impacts of SC integration (SCI) on halal food SC integrity and, consequently, food quality.

Design/methodology/approach: Empirical data were collected from 275 halal-certified food companies in Malaysia and analysed using structural equation modelling – SmartPLS3.0.

Findings: The results confirmed that SCI, including internal, supplier and customer integrations, has significant effects on the dimensions of …

The Separation Of Legislative Powers In The Initiative Process, Anthony Johnstone

Nebraska Law Review

Direct democracy cannot implement itself. From Nebraska’s introduction of a state law authorizing the initiative at the local level in 1897,1 through the first constitutional amendments authorizing state-wide initiative processes in several states at the turn of the Twentieth Century, and subsequent efforts to expand the initiative power to approximately half the states,2 legislatures must share the legislative power with the people in states that provide the initiative. After the initial allocation of legislative power to initiative processes, usually through relatively detailed constitutional provisions, state legislatures become responsible for supporting the initiative power. In authorizing initiatives, state constitutions also authorize …

A Language For The World: The Standardization Of Swahili, Morgan J. Robinson

Ohio University Press Open Access Books

This intellectual history of Standard Swahili explores the long-term, intertwined processes of standard making and community creation in the historical, political, and cultural contexts of East Africa and beyond.

Morgan J. Robinson argues that the portability of Standard Swahili has contributed to its wide use not only across the African continent but also around the globe. The book pivots on the question of whether standardized versions of African languages have empowered or oppressed. It is inevitable that the selection and promotion of one version of a language as standard—a move typically associated with missionaries and colonial regimes—negatively affected those …

Safety, Regulatory And Environmental Issues Related To Breeding And International Trade Of Edible Insects In Africa, S. Niassy, E. R. Omuse, N. Roos, A. Halloran, J. Eilenberg, J. P. Egonyu, C. Tanga, F. Meutchieye, R. Mwangi, S. Subramanian, R. Musundire, P. O.Y. Nkunika, J. P. Anankware, J. Kinyuru, A. Yusuf, S. Ekesi

All Peer-Reviewed Publications

Insect breeding or farming for food and feed is an emerging enterprise that can address the ever-growing demand for protein and curb high unemployment rates in Africa and beyond. However, for the sector to prosper, its value chain needs to be regulated to ensure sustainability and safety for consumers and the environment. Although a few African countries, such as Kenya, Uganda and Rwanda, have promulgated standards on the use of insects as food and feed, greater efforts are needed in other countries, and relevant policies governing the sector need to be formulated. All over the globe, attention to the regulation …

How Shame Shapes Church Planting : Exploring Impacts On Gospel Receptivity Among Emerging Adults, Robert Mark Montgomery

ATS Dissertations

No abstract provided.