Digital Commons Network^™

Evaluation Of Pulmonary Toxicity To Inhaled Erbium Oxide Nanoparticles In Golden Syrian Hamsters, Randy Liang

Theses and Dissertations

Erbium oxide nanoparticles (Er2O3 NPs) are used in various products from simple pottery to semiconductors and such usage leads to an elevated risk of accidental occupational exposure. In the present study, the pulmonary toxicity of Er2O3 NPs was assessed by examining tissues and bronchoalveolar lavage fluid (BALF) from the lungs of Golden Syrian Hamsters following inhalation exposure. The study’s goal was to determine the severity and mechanism of toxicity upon exposure to inhaled Er2O3 NPs. Animals were divided into 4 groups all being exposed for 4 hours a day for 8 days: Group-1: room air, Group-2: vehicle control (water), Group-3: …

Evaluation Of The Mechanism Of Cell Death After Exposure To Amorphous Silicon Dioxide Nanoparticles In Rat Pleural Mesothelial Cells And Golden Syrian Hamsters, Rachel P. Renda

Theses and Dissertations

Amorphous Silicon Dioxide Nanoparticles (SiO2 NPs) are widely used in the industrial processes, chemical, and cosmetics industries. Amorphous SiO2 NPs are abundant in the earth’s crust and can be released into the air through industrial and manufacturing activities. Such particles are overlooked and not as commonly studied when compared to their crystalline counterpart. Amorphous SiO2 NPs are pulmonary toxicants; however, the mechanism of toxicity is uncertain. In the current study, toxicity was assessed using both in vitro and in vivo systems to understand a possible mechanism of cell death. Rat Pleural Mesothelial Cells (RPMCs) were exposed to 50-800 μg/ml SiO2 …

Utilizing A Genetically Diverse Species To Investigate Gene-Drug Interactions And Drug Efficacy, Jerry Nawongbay Gbarlea

Theses and Dissertations

Gene-drug interactions are fundamental to understanding variability in drug response and therapeutic efficacy. In this project, we leverage the natural genetic divergence between ecotype morphs of the blind Mexican cavefish (Astyanax mexicanus) to investigate differential responses to neuroactive compounds—specifically, the convulsant pentylenetetrazol (PTZ) and the anxiolytic Buspirone Hydrochloride. Astyanax Mexicanus is a tetra species consisting of both surface-dwelling (ancestral) and cave-dwelling (mutant) populations that have highly variable genetic backgrounds. Independently evolved populations of cavefish exhibit a suite of convergent traits that can be functionally interrogated to discover new genetic functions and interactions. These attributes make A. mexicanus an ideal model …

Mass Tourism And Sustainability Discourses: A Rhetorical Analysis Of Stakeholder Communication Across The Canary Islands, Iceland, And Puerto Rico, Carmen Collins

Theses and Dissertations

This study analyzes 123 websites from the Canary Islands, Iceland, and Puerto Rico, each including an equal number of tourism businesses, environmental organizations, and governments from each region, to examine the rhetorical digital communication strategies used and the textual differences between these websites. Thematic analysis was the methodology employed in this study. Ten themes were found inductively from the data, which are: 1) economic value framing, 2) cultural identity and heritage, 3) technological mediation, 4) inspiring guilt, awe, and urgency, 5) sustainability as an instrument, 6) intergenerational responsibility, 7) global versus local contestations, 8) accessibility and inclusion, 9) transparency and …

Rooted In Education: Defining And Exploring Characteristics Of School Learning Gardens And Their Influence On Student Development In Urban Settings, Jason Samuel Fuller

Theses and Dissertations

This study employed an explanatory sequential mixed-methods research design, grounded in a constructionist framework, to investigate the educational significance and perceived impact of school learning gardens in urban settings. It examined the intended outcomes of various school garden models, including their contributions to academic achievement, health, community engagement, and social-emotional well-being. The study explored similarities and differences among school gardens and the perceptions of school administrators and garden facilitators regarding their value, as well as how garden design and characteristics relate to student experiences and educational goals. Quantitative data were drawn from publicly available sources, including the NYC DOE’s Sustainability …

Block Form And Grossform: Bigness Reconsidered, Edgar G. Adams Jr.

Architecture, Art, and Historic Preservation Faculty Publications

During the 20th Century, architecture’s relationship with the city underwent a profound transformation that can be most clearly seen in the changing attitudes regarding the role of the urban block as a constituent component of the urban fabric. The introduction of the car and the increasing scale of urban development prompted a reexamination of both the block and its defining streets. This paper examines the remarkable convergence of architects seeking to distance themselves from CIAM modernism under the banner of ‘Rationalism’ and their ultimately divergent positions regarding rebuilding efforts in Berlin during the run up to the 1984/87 IBA. During …

Amyloid Β-Cholesterol Interplay: Removal Of Cholesterol From The Membranes To Catalyze Aggregation And Amyloid Pathology, Rishiram Baral, Ruan Van Deventer, Yuri L. Lyubchenko

Journal Articles: Pharmaceutical Sciences

The interplay between the cholesterol metabolism and assembly of Aβ42 (the 42-residue form of the amyloid-β peptide) peptides in pathological aggregates is considered one of the major molecular mechanisms in the development of Alzheimer's disease (AD). Numerous in vitro studies led to the finding that high cholesterol levels in membranes accelerate the production of Aβ aggregates. The molecular mechanisms explaining how cholesterol localized inside the membrane bilayer catalyzes the assembly of Aβ aggregates above the membrane remain unknown. We addressed this problem by combining different AFM modalities, including imaging and force spectroscopy, with fluorescence spectroscopy. Our combined studies revealed that …

In The Wake Of The Anthropocene: The Ecopoetics Of Shakespearean Film Adaptations, Ioannis Garganourakis

Theses and Dissertations

This dissertation explores how Shakespeare’s plays and their film adaptations reflect and respond to the conditions of the Anthropocene, arguing that both forms of art can foster an environmental ethic attuned to the interconnectedness of human and nonhuman worlds. It proposes that the Anthropocene did not begin with industrialization but rather intensified a much older pattern of human ecological intervention, a process that becomes increasingly visible from the early modern period to the twentieth century. By situating Shakespeare within this expanded temporal framework, this dissertation reveals how his works anticipate and interrogate the very assumptions about anthropocentrism that underpin modern …

Biogothic: New Directions In The Haunted Spaces Of Nineteenth Century Gothic Fiction, Jessica Mintzes

Theses and Dissertations

The BioGothic is a set of biological metaphors in nineteenth century Gothic fiction that anticipates our contemporary understanding of what we now think of as biological processes. The BioGothic system in the novel captures the site of connection and interaction between the body and the interior spaces it inhabits. The Gothic genre, from its inception, shifts the focus onto interior spaces and the ways in which architectural spaces and the Gothic body interact with one another. This demonstrates, in part, how physical space and biological matter are not only capable of becoming integrated with each other, but also maintain the …

Compensatory Responses To Glaucoma Pathology In The Dorsolateral Geniculate Nucleus, Shaylah Mccool, Arnav Jain, Jennie C. Smith, Victoria L. Schaal, Gurudutt Pendyala, Sowmya V. Yelamanchili, Matthew J. Van Hook

Journal Articles: Anesthesiology

Glaucoma disrupts the conveyance of retinal signals to visual regions of the brain such as the dorsolateral geniculate nucleus (dLGN) due to degeneration of retinal ganglion cells (RGCs) and their axons. Although plasticity during development allows altered visual experience to modulate dLGN synapses and excitability, evidence for experience-dependent dLGN plasticity in adults is limited. However, glaucoma might trigger compensatory plasticity in adult dLGN, thereby compensating for diminished RGC synaptic drive. Here, we tested this theory using aged DBA/2J mice, which develop high intraocular pressure and glaucoma. In brain slice recordings, we found that diminished RGC inputs could drive robust action …

Differential Sensitivity Of Leukocyte Populations To Staphylococcus Aureus Biofilm, Nichole D. Brandquist, Tammy Kielian

Journal Articles: Pathology and Microbiology

Staphylococcus aureus is a leading cause of prosthetic joint infection (PJI) typified by biofilm formation. Anti-inflammatory granulocytic myeloid-derived suppressor cells (G-MDSCs) represent the main leukocyte population in a mouse model of S. aureus PJI, followed by neutrophils (PMNs), and macrophages (Mφs), which is also seen during human PJI. Defining how each leukocyte population responds to S. aureus biofilm vs planktonic bacteria could have important implications for how S. aureus evades immune detection to facilitate biofilm persistence. This study compared the kinetics of leukocyte death and relationship to mitochondrial ROS (mtROS) production following exposure to planktonic S. aureus or biofilm. Mφs …

Board Of Pharmacy, Lara Horhor, Katie Gonzalez, Marcus Friedman

California Regulatory Law Reporter

No abstract provided.

2025 Town Of Littleton, Nh Annual Town Report, Littleton Town Representatives

Littleton, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Budget For The Fiscal Year Ending June 30, 2026, University Of Arkansas, Fayetteville

Budget for the Fiscal Year

No abstract provided.

The Hidden Narrative: How The Clean Water Act Wetlands Program Culminated In Sackett, Sam Kalen

Wyoming Law Review

Two federal employees lay murdered on property presumably being developed in violation of the Clean Water Act (CWA).¹ Should those federal officials from the Environmental Protection Agency (EPA) have been there? Was the land even subject to the CWA’s Section 404 wetland program? Or possibly, was this yet another version of what confronted an Idaho couple back in 2012, this time in the central reaches of sparsely populated Wyoming? After all, the Idaho couple, Mr. & Mrs. Sackett, argued that their property, just 300 feet from Priest Lake, Idaho, was not a wetland capable of being regulated by the …

Evaluating Cow/Calf And Stocker Performance When Grazing Sudangrass With And Without Sunnhemp, Shelby L. Davis-Jenkins, Daren D. Redfearn, Mary E. Drewnoski

Nebraska Beef Cattle Reports

Summary with Implications

Sudangrass can provide high-quality summer forage, supporting cow/calf pairs and growing cattle. In this study, sudangrass or a sudangrass–sunnhemp mix was grazed over two years by cow/calf pairs and heavy stockers (~880 lb). There was no difference in carrying capacity between forage types. Sunnhemp inclusion had no effect on cow body condition or nursing calf gain. Cows maintained condition through peak lactation, and nursing calves gained 2.27 lb/day. Stockers gained 1.56 lb/day on sudangrass alone and 1.73 lb/day on the mix. However, the added seed cost of sunnhemp increased the cost of gain in year 1 and …

From Border-Based To Status-Based Mandatory Immigration Detention, Mary Holper

Fordham Urban Law Journal

No abstract provided.

In Vitro Dihalobenzene Nephrotoxicity In Isolated Kidney Cells, Jana Ahmed Sherif

Theses, Dissertations and Capstones

Brominated and chlorinated benzenes are common industrial chemicals linked to kidney injury. This study evaluated the nephrotoxicity of several mono- and dihalogenated derivatives using isolated kidney cells from male Fischer 344 rats. LDH release and trypan blue exclusion were measured after 30- and 60-minute exposures to 0.25–1.0 mM to test compounds. Toxicity increased with increased concentration and longer times. Mixed-halogen bromobenzenes, particularly 1-bromo-4-chlorobenzene, showed one of the highest toxicity levels, while 1,4dichlorobenzene was the most toxic chlorobenzene. Antioxidants (glutathione, ascorbate, and αtocopherol) markedly reduced injury, indicating oxidative mechanisms play a role in toxicity. cytochromes P450 (CYP) inhibitors (piperonyl butoxide and …

Missing The Forest For The Trees:The Supreme Court Of Canada’S Formalistic Approach Inthe Iaa Reference A Setback For Environmental And Climate Law In Canada, Nathalie J. Chalifour

The Supreme Court Law Review, Third Series: Osgoode's Annual Constitutional Cases Conference

This article explores whether the Supreme Court of Canada majority’s reasons in the Reference re Impact Assessment Act missed the forest for the trees. By applying a literal interpretation to the definition of “effects within federal jurisdiction” and what the Court called the “interprovincial effects clause” in the legislation, the majority departed from decades of flexible, purposive interpretation of environmental legislation. This article highlights three interrelated critiques of this aspect of the decision. First, it unpacks the way in which the majority’s reasons run contrary to the Supreme Court’s consistent approach to interpreting environmental legislation in previous decisions, inviting readers …

Leaving The Charter At Home: From Hape To Mcgregor, Gerald Chan, Benjamin Zolf

The Supreme Court Law Review, Third Series: Osgoode's Annual Constitutional Cases Conference

Almost 20 years ago, in R. v. Hape, the Supreme Court held that Canadian police investigations can proceed unfettered by constitutional constraints, so long as they take place outside of Canada. The Court recently had the opportunity to revisit this position in R. v. McGregor, but declined to clarify Hape, let alone revisit it. This paper argues that this was a missed opportunity. Hape rests on the flawed premise that the extraterritorial application of the Charter would interfere with other nations’ sovereignty. The three exceptions to Hape’s general rule of non-extraterritorial application are either illusory or in tension with that …

Examining The Association Between Ddt Exposure And Parkinson’S Disease, Hodges Mccathern

Undergraduate Honors Theses

Dichlorodiphenyltrichloroethane, commonly known as DDT, was an organochlorine pesticide widely used in the mid-20th century. It is highly stable and resistant to degradation, leading to its long-term presence in the environment. This chemical bioaccumulates in ecosystems and in human tissue, particularly adipose tissue, raising concerns about chronic exposure. Emerging research links DDT exposure to adverse neurological outcomes, including increased risk for neurodegenerative disorders such as Parkinson’s Disease. Mechanistically, DDT and its metabolites may disrupt dopaminergic neurons, induce oxidative stress, and interfere with mitochondrial function, contributing to neurotoxicity. Understanding the environmental fate of DDT and its bioaccumulative properties is essential for …

The Association Between Personal Particulate Matter Exposures And Cognitive Function Among Stroke Patients, Kentucky, Usa, Nana Afua Ankomah Dei

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Stroke, a major cause of long-term disability and cognitive problems in the U.S., significantly affects people’s quality of life. Exposure to particulate matter (PM_2.5) may result in systemic inflammation and oxidative stress, which can worsen the cognitive function of post-thrombectomy stroke patients. This project thus assessed the relationship between PM_2.5 exposure and its effect on the cognitive function of post-thrombectomy stroke patients. Fifteen stroke patients (9 non-Appalachian and 6 Appalachian) undergone thrombectomy were recruited. Personal PM_2.5 exposure was measured using wearable sensors for a week during the study period. Montreal Cognitive Assessment (MoCA) scores and covariates …

Now, How Shall We Be? This Cultural Moment And Our Christian Response: Chapter 1: Old Moorings, Ken Badley

Faculty Publications - College of Education

As we embark on this book's quest to understand this cultural moment and possible Christian responses to it, we will begin in this chapter by considering several anchor points to which western civilization previously tied itself. For the most part, these old moorings provided an agreed-upon worldview that brought security and meaning to society. Over time, as people's perspectives changed, our culture slipped away from its previous sources of confidence or even certainty. Before we begin to explore our current, unmoored, cultural moment, we need to survey, at least briefly, what these old moorings were and why they have faded …

Largemouth Bass Diet Changes Through The Summer In Central Minnesota, Ethan Kunz

Journal of Earth and Life Science

Largemouth Bass Micropterus nigricans is one of the most widespread fish species in the world, due in part to human introduction for angling. Largemouth Bass are opportunistic predators that will consume the largest prey they can often find; however, it has been shown that their diet mainly consists of invertebrates such as crayfish, with less focus on other fish species. This research aimed to determine what the Largemouth Bass diets in Central Minnesota consist of, and how they may change from the beginning of summer through the beginning of fall. A total of 174 Largemouth Bass were sampled from late …

Relationship Between Ratio Of Hybrid Sunfish To Their Parent Species And Latitude, Maxwell Kattner

Journal of Earth and Life Science

Hybrid sunfish of the Lepomis genus make up a generally small but notable portion of the population of sunfish in Minnesota lakes. Hybrid sunfish play a significant role in freshwater ecosystems across the United States. They are both morphologically and behaviorally distinct in some ways and similar in other ways to their parent species, causing them to both fill and compete with their parent species for niches occupied by multiple Lepomis species. Despite this, the ratio of hybrid sunfish to their parent species has never been properly explored. This study observed if the ratio of hybrid sunfish to their parent …

Redness As Fact And Sensibility In Mindanao’S Abaca Ikat Cloth, Cherubim Quizon

Department of Sociology, Anthropology and Social Work Publications

This paper proposes an approach to the color red as a central consideration in cloth making in the southern Philippines where thread is made from abaca (Musa textilis), a historically and economically significant plant in the banana family. It focuses on red dye derived from the root of the Morinda plant (Morinda citrifolia) and how it is utilized and theorized, both pragmatically and metaphorically, by indigenous women of Mindanao. Drawing on research that relies on ethnographic fieldwork and informed by early 20th century American museum collecting during a time of pacification, this paper frames a phenomenological query using mixed methods …

Synergistic Effects Of Salinization And Artificial Root Exudates On Soil Phosphatase Activity In Coastal Soil, Nicolina Lentine, Sarah E. Krisak, Dirk W. Vanderklein, Matthew S. Schuler, Nina M. Goodey

Department of Biology Faculty Scholarship and Creative Works

Coastal soil salinization from rising seawater levels has adverse impacts on soil function, seed germination, and plant growth. Root exudates play a key role in supporting microbial activity, nutrient cycling, and plant health, yet little is known about the combined effects of salinization and the addition of artificial root exudates (AREs) on soils. We investigated the impacts of sodium chloride (NaCl) and AREs, alone and in combination, on soil microbial function and the growth and survival of Chamaecyparis thyoides saplings. In a three-by-three fully factorial matrix, the combined NaCl and AREs treatment increased soil phosphatase activity more than the additive …

Captive Model Test For Hydrodynamic Derivatives Of Ship Maneuvering In Regular Head Waves, Pin-Yuan Huang, Zih-Yao Lin, Tsung-Yueh Lin, Fu-En Lee, Yan-Wei Lai

Journal of Marine Science and Technology–Taiwan

The motion of ship in wave can be discussed in seakeeping and maneuvering. In model tests, the former is found by the motion response of waves while the latter requires captive model test to acquire hydrodynamic derivatives. The hydrodynamic derivatives in waves are discovered to be different from those in calm water. To understand better the behavior of maneuverability in waves, maneuvering tests in a wide range of waves are performed in this study. This study presents an experimental investigation into the maneuvering behavior of a container ship in regular waves, covering a wide range of wavelengths from half to …

Engage & Empower Vol. 2, Elhanan Marvit

Open Touro Created

2026

Engage & Empower, Volume 2 is the second installment in the “Engage & Empower” OER series by Elhanan Marvit LCSW. It serves as the logical next step following Volume 1 (Spring 2025). While the first volume introduced foundational concepts in social work practice, ethics, and generalist skills This volume guides students and readers deeper into the applied, interpersonal, and reflective dimensions of becoming a competent practitioner.

Students begin their reading journey as they strengthen their understanding of professional competence. They achieve this by learning how to navigate field placements, engage in supervision, manage boundaries, and integrate feedback. The text …

Advancing Menstrual Health And Hygiene In Rural Kenya: A Guideline Based Approach, Tessia R. Winnfield

Doctor of Nursing Practice (DNP) Scholarly Projects - Archive

Objective: To develop an evidence-based clinical practice guideline for menstrual health management addressing menstrual education, teacher training, menstrual school absenteeism, male student engagement, pain management, and provision of menstrual kits with product options.

Design: This evidence-based practice guideline development project used the Agency of Healthcare Research and Quality (AHRQ) Framework and the Johns Hopkins Nursing Evidence-Based Practice Model (JHNEBP). I conducted a systematic literature review and a critical appraisal to identify best practices for menstrual hygiene interventions in rural communities.

Setting: The guideline development occurred within an academic Doctor of Nursing Practice program focused on rural communities.

Participants: Seven stakeholders …