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Turkish Journal of Veterinary & Animal Sciences

No abstract provided.

Pathological And Immunohistochemical Changes In The Liver Of Monocrotaline-Treated Rats, Şevket Soylu, Aydin Çevi̇k, Necati̇ Ti̇murkaan

Turkish Journal of Veterinary & Animal Sciences

Pathological and immunohistochemical changes in livers were investigated in monocrotaline-treated rats. Eighty adult-male Wistar rats were distributed in 5 groups, each containing 16 animals according to monocrotaline dose (Group I: 50 mg/kg, Group II: 100 mg/kg, Group III: 150 mg/kg, and Group IV: 200 mg/kg). The control group was administered with physiological saline. Half of the animals in each group were euthanized at the 18th hour while the remaining half at the 6th week postinoculation. At the end of the 18th hour, the most prominent lesion was hepatocytic apoptosis which was dose-dependent. Apoptotic cells were mostly located in periportal and …

Faculty Authors & Achievers Bibliography 2022, Luke Vilelle

WRL: Faculty Authors & Achievers Bibliographies

The office of Academic Affairs and the Wyndham Robertson Library congratulate all Hollins faculty who published or presented creative or scholarly works from Fall 2020 - Summer 2022. These pages include a list of those activities.

Research Handling Effects On Stress Hormones, Blood Parameters, And Heart Rate In Juvenile Northern Elephant Seals (Mirounga Angustirostris), Lauren A. Cooley

Master's Theses

Wildlife researchers must balance the need to safely capture and handle their study animals to sample tissues, collect morphological measurements, and attach dataloggers while simultaneously ensuring their results are not confounded by stress artifacts caused by handling. To determine the physiological effects of research activities including chemical immobilization, transport, instrumentation with biologgers, and overnight holding on a model marine mammal species, I collected hormone, blood chemistry, hematology, and heart rate data from 19 juvenile northern elephant seals (Mirounga angustirostris) throughout a translocation experiment. Across my six sampling timepoints, cortisol and aldosterone data revealed a moderate hormonal stress response to handling …

Mild Cognitive Impairment In Presurgical Deep Brain Stimulation For Parkinson's Disease, Elizabeth Roslyn Wallace

Theses and Dissertations--Psychology

Although clinically characterized by motor impairments, Parkinson's disease (PD) often affects cognition early in the disease course. Cognitive changes common in PD include visuospatial abnormalities and prominent executive function (EF) deficits, with 30% of individuals eventually developing Parkinson’s disease dementia (PDD). Mild cognitive impairment (MCI) has been identified as a transitional state between normal cognition and PDD. A large cohort of individuals with PD at the Kentucky Neuroscience Institute have undergone pre-surgical evaluations for deep brain stimulation, although cognitive performance in this cohort has never been probed. Baseline cognitive performance of this cohort from 2017-2020 was examined to characterize the …

The Measurement Of Product Typicality In Design Research. A Basic And Applied Approach, Travis Kent

Theses and Dissertations--Psychology

The objective of this study was to examine the use of the cognitive construct of “typicality” to guide design decisions in the development of consumer products. Increasing products that will appeal to consumers, designers strive to balance novelty and familiarity. A potential way to thread this needle is to understand how “typical” a design is of its particular product category. The construct of typicality has been used by psychologists to understand how people create and represent categories. Objects that are more typical of a category are often associated with positive responses from observes (e.g., greater visual appeal, faster recognition). In …

Effects Of An Online Insomnia Intervention On Sleep And Alcohol Consumption, Justin Verlinden

Theses and Dissertations--Psychology

Alcohol use disorder (AUD) and insomnia are highly comorbid, due in part to the use of alcohol as a sleep aid among individuals with insomnia. Initial studies have shown that cognitive behavioral therapy for insomnia (CBT-I), the first-line treatment for insomnia, is moderately successful at improving both sleep and drinking outcomes in heavy drinkers with insomnia. However, CBT-I is expensive and not widely available. Online CBT-I could be a more accessible alternative. One online CBT-I program, Sleep Healthy Using the Internet (SHUTi), is especially promising due to its high efficacy in treating insomnia and its individualized and interactive platform. Here …

Recent Law Reforms In Eu Sustainable Finance: Regulating Sustainability Risk And Sustainable Investments, Felix Mezzanotte

American University Business Law Review

Responding to increasingly degrading environmental and social conditions, the European Commission has fostered important legal and regulatory reforms to achieve sustainable finance objectives in Europe. However, these reforms are numerous, complex, and fast-paced. They have proved difficult to grasp and contextualize, while adding to the intricacies of an already highly sophisticated EU legal and regulatory regime. This Article outlines and examines such reforms with the purpose of providing necessary insights into the current state of EU law and regulation in the area of sustainable finance. The first part of the Article conceptualizes the meaning of sustainability risk and of sustainable …

“The Bonn Master-Baker Gottfried Fischer’S Reminiscences Of Beethoven’S Youth” [Des Bonner Bäckermeisters Gottfried Fischer Aufzeichnungen Über Beethovens Jugend]. Translated Into English, With Editorial Commentary And Notes., Susan Cooper

The Beethoven Journal

No abstract provided.

Multimodal Ultrasound Imaging For Improved Metastatic Lymph Node Detection, Sidhartha Jandhyala

Dartmouth College Ph.D Dissertations

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and is complex in nature due to the variety of organs located in the head and neck region. Knowing the metastatic state of the lymph nodes is paramount in accurately staging and treating HNSCC patients. Currently, metastatic lymph node detection involves the use of magnetic resonance imaging and/or x-ray computed tomography, followed by biopsies for histological confirmation. The main diagnostic criteria is the size of the nodes; however, current imaging methods are not 100% accurate due natural lymph node variability. Ultrasound imaging is able to provide …

The Emotional Side Of Dynamic Assessment: L2 Writing From Vygotsky's Perezhivanie Lens, Ali Kushki

Dissertations

This qualitative multiple-case study investigated the emotional perceptions of English-as-a-foreign language learners (EFLs) and an English writing instructor as they met online via the Zoom application. Dynamic Assessment (DA) and the Vygotskyan perezhivanie notion guided the study. DA is an interactive assessment approach that combines instruction and assessment processes during student-instructor interactions with the goal of diagnosing and developing learners’ abilities. As to the perezhivanie notion, Vygotsky (1994) argued for uncovering the particular prism through which the individual refracts (i.e., shapes) the influence of the environment, and how she “becomes aware of, interprets, and emotionally relates to a certain event” …

Things Of Beauty: Aesthetics For Environmental Education, Annie Schultz

Dissertations

As environmental crisis looms large, most agree that human reeducation is necessary in order to improve our relationship to the natural environment. Yet, there is currently no comprehensive interdisciplinary philosophy of education for environmental awareness. While there is writing in the field of philosophy of education on ecologizing education and literature which draws connections between aesthetic education and the appreciation of nature, there is little literature on the explicit ways in which aesthetic and art education can inform environmental justice initiatives. This dissertation examines aesthetic and art education’s relationship to the environment and how aesthetics can inform a moral relationship …

Things Of Beauty: Aesthetics For Environmental Education, Annie Schultz

Dissertations

As environmental crisis looms large, most agree that human reeducation is necessary in order to improve our relationship to the natural environment. Yet, there is currently no comprehensive interdisciplinary philosophy of education for environmental awareness. While there is writing in the field of philosophy of education on ecologizing education and literature which draws connections between aesthetic education and the appreciation of nature, there is little literature on the explicit ways in which aesthetic and art education can inform environmental justice initiatives. This dissertation examines aesthetic and art education’s relationship to the environment and how aesthetics can inform a moral relationship …

Comparison Of First-Time Neurocognitive Baseline Cognigram Assessments Between American And Brazilian Professional Bull Riding Athletes, Peter Wang

University of the Pacific Theses and Dissertations

The purpose of this study was to compare the first-time neurocognitive concussion baseline outcomes, using the Cognigram assessment software, between American and Brazilian professional bull riders. The analysis was performed using the database provided by the Professional Bull Riding Association Sports Medicine staff. The Cognigram assessment measures and analyses four outcomes: Psychomotor Function, Attention, Learning, and Working Memory Speed. The study examined the test outcomes of 210 professional bull riders (150 American, 60 Brazilian). A one-way multivariate analysis of covariance (MANCOVA) was used to determine if there a significant difference in the four assessment outcomes when comparing the country of …

Peripherally Restricted Opioid Conjugates And Its Use As Pharmacological Probes And Potential Therapeutics, Md Tariqul Haque Tuhin

University of the Pacific Theses and Dissertations

Opioid-induced constipation (OIC) is one of the major adverse effects of opioid analgesics used by millions of patients each year. While progress has been made, there remains a significant unmet medical need in the treatment of OIC. Major gaps remain in our understanding of the role of the gastrointestinal tract and central nervous system (CNS) in precipitating OIC. For the last four decades, numerous investigations to study the sites of action of opioid analgesics have utilized peripherally acting mu-opioid receptor antagonists (PAMORAs), which have been incorrectly believed to have limited penetration across the blood-brain barrier (BBB). Several preclinical and clinical …

B Cells In The Gut Associated Lymphoid Tissue (Galt), Ameera Bukhari

Dissertations

The gut-associated lymphoid tissue (GALT) is the largest mass of lymphoid tissue in the body, and it is a unique line of defense where immune cells are in constant contact with gut commensals and pathogens. B lymphocytes constitute most of the lymphatic tissues of the gastrointestinal (GI) tract and they play a critical role in protecting from infections, promoting tolerance, and shaping microbiota in the gut through the production of immunoglobulins (Ig). Previous studies on GALT B cells in human showed that large B cell clones in the body partition into two broad networks: one includes the blood, bone marrow, …

Microplastic Accumulation In Riverbed Sediment Via Hyporheic Exchange From Headwaters To Mainstems, Jennifer D. Drummond, Uwe Schneidewind, Angang Li, Timothy J. Hoellein, Stefan Krause, Aaron I. Packman

Biology: Faculty Publications and Other Works

In rivers, small and lightweight microplastics are transported downstream, but they are also found frequently in riverbed sediment, demonstrating long-term retention. To better understand microplastic dynamics in global rivers from headwaters to mainstems, we developed a model that includes hyporheic exchange processes, i.e., transport between surface water and riverbed sediment, where microplastic retention is facilitated. Our simulations indicate that the longest microplastic residence times occur in headwaters, the most abundant stream classification. In headwaters, residence times averaged 5 hours/km but increased to 7 years/km during low-flow conditions. Long-term accumulation for all stream classifications averaged ~5% of microplastic inputs per river …

Zero Tolerance Atrocity Crimes Against Migrant Children And Families In The United States: An Accountability Framework For Family Separation, Sarah Diaz Jd, Llm, Jenny Lee Phd

Center for the Human Rights of Children

No abstract provided.

Molecular Mechanisms Of Oxidative Stress-Induced Corneal Damage And The Use Of Antioxidants And Therapeutics, Anita Kirti Ghosh

Dissertations

Dry eye disease represents an urgent unmet clinical need. This dissertation explores the underlying pathophysiological mechanisms of ocular surface disease in small and large animal models and provides feasibility for the development of antioxidants as novel therapeutics for dry eye disease. Dry eye disease affects 50 million Americans every year, and costs about $55 billion annually in the USA. The disease manifests as ocular irritation, burning, foreign body sensation, and blurry/cloudy vision. While it is widely accepted that oxidative stress plays a critical role in the pathophysiology of the disease, little is understood about the underlying molecular mechanisms. The purpose …

A Phenomenological Study Of Catholic Priests Working And Headteachers In Government - Funded Catholic Secondary Schools, Joseph Kaye

Dissertations

ABSTRACT

The purpose of this qualitative phenomenological study is to explore the skills, behaviors and lived experience of priests who are headteachers in government-funded Catholic secondary schools in Butare Catholic diocese. This study might help the bishop and diocesan policy makers in identifying the type of formation, skills and behaviors priests need to be effective headteachers in Catholic schools. To achieve the purpose of this study, I used a phenomenological methodology to collect and analyze the data. The participants in this study are priests who are headteachers in government-funded Catholic secondary schools of Butare Catholic diocese. The major goals of …

Abl2 Promotes Alcohol-Associated Liver Disease Via Ppar Gamma Regulation, Gregory Malnassy

Dissertations

Alcohol-associated liver disease (AALD) is an umbrella term for a spectrum of diseases resulting from chronic alcohol (e.g. ethanol) abuse ranging in severity from reversible conditions such as alcohol-induced steatosis to advanced and largely irreversible liver pathologies including alcoholic steatohepatitis (ASH), alcoholic hepatitis (AH), fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). AALD is one of the primary causes of chronic liver disease worldwide and accounts for 44% of liver disease deaths in the United States. Drinking rates, both in the United States and globally, have increased year over year for the past three decades, a trend which has resulted in significantly …

Elucidating The Role Of Kmt2d In Her2+ Breast Cancer, Emily Ma

Dissertations

Breast cancer is the second leading cause of cancer-related deaths among women in the US. Histone modifications are common epigenetic changes that have been implicated in several breast cancers, including HER2+ breast cancers. Current therapies, such as trastuzumab, block the HER2 receptor to reduce tumor growth. Unfortunately, HER2+ breast cancers have found ways to overcome these therapies, leading to tumor resistance, metastases, and poor survival outcomes. A better understanding of the underlying mechanisms contributing to HER2+ breast cancer resistance may lead to the discovery of novel therapeutic strategies to improve patient outcomes.One prognostic marker for poor survival in women with …

Unlocking Desistance: The Role Of Executive Functioning In The Rehabilitation Of Correctional Populations, Danielle Nesi

Dissertations

In a secondary analysis of data collected by Fishbein and Sheppard (2006), the current study sought to explore the relationships among age, executive functioning and antisocial behavior (e.g., changes in institutional infractions, self-reported aggression and reactivity) among a sample of incarcerated men enrolled in a correctional Cognitive Behavioral Therapy (CBT) program between 2003 and 2005. Specifically, the current study examined whether baseline executive abilities predicted misconduct and whether this relationship was mediated by treatment engagement. The relationships among age, treatment engagement, and changes in executive functioning post-treatment were also considered. It was predicted that improvements in executive functioning would vary …

Leveraging Moral Foundations To Increase Covid-19 Vaccination, Cara Elizabeth Ray

Dissertations

Despite the vast majority of the eligible U.S. adult population being vaccinated against COVID-19, geographical clusters of unvaccinated individuals pose a substantial risk of outbreak. It is important to encourage as many individuals as possible to vaccinate against COVID-19 to reduce its spread and severity. Past research has identified endorsement of the purity and liberty moral foundations – intuitive domains of moral concern – as predictors of vaccine hesitancy and political conservatism, while conservatism is itself associated with vaccine hesitancy. Across two online surveys, I examined the effects of a message invoking the purity and liberty foundations as well as …

The Role Of Glycogen Synthase Kinase 3 Β (Gsk-3Β) At The Cardiac Myofilament, Marisa Jean Stachowski

Dissertations

Altered kinase activity and localization is gaining appreciation as a mechanism contributing to cardiovascular disease. Previous work suggests that the kinase glycogen synthase kinase 3 β (GSK-3β) regulates contractile function of the myofilament, but this work was performed in vitro. The goal of this work was to investigate GSK-3β’s in vivo role in regulating myofilament function, the mechanisms involved, and the translational relevance in disease. GSK-3β’s myofilament localization was confirmed in wild type mouse and human tissue via western blot of myofilament enriched tissue and immunofluorescence. These experiments also revealed that GSK-3β phosphorylated at Y216 binds to the z-disc. We …

Healing Earth In A Time Of Crisis: Curriculum For Integral Ecology, Caleb Steindam

Dissertations

This intrinsic multiple case study examined secondary- and university-level educators’ experiences teaching with Healing Earth, a curriculum developed by the International Jesuit Ecology Project at Loyola University Chicago, which merges scientific, social, spiritual, and ethical analyses of pressing ecological issues. Based on the conceptual framework of integral ecology, Healing Earth is a response to Pope Francis’s (2015a) call for “a new way of thinking about human beings, life, society and our relationship with nature” (§215).

This study primarily consisted of in-depth interviews with educators who have used Healing Earth in a variety of secondary and post-secondary Catholic educational contexts. A …

Does Co-Speech Gesture Support Children’S Analogical Reasoning? An Investigation Into The Differential Effects Of Gesture On Learning, Amy Michelle Wilkinson

Dissertations

A well-established conceptualization of academic capitalism is rooted in the marriage of economic theory and critical social. Significantly, academic capitalism links economic dimensions with the political-ideological transformations of U.S. society associated with the fall of communism and the rise of neoliberalism. Academic capitalism is based on a recognition of the paradoxical nature of higher education and offers a lens through which to examine the ways in which institutions in the United States have come to prioritize learning for the labor market as a private good within the new global economy, while also becoming less beholden to the notion of learning …

Determination Of The Ecological Water Quality In The Orienco Stream Using Benthic Macroinvertebrates In The Northern Ecuadorian Amazon, Federico Sinche, Manuel Cabrera, Lenin Vaca, Edin Segura, Pablo Carrera

School of Environmental Sustainability: Faculty Publications and Other Works

In recent years, pollution of watercourses in nearby protected ecosystems has increased due to urbanization. Standard physiochemical methods and probes are one way to monitor watercourses for quality. However, they often do not provide the full ecological status of the body of water. In this work, we set out to assess the ecological water quality of an urban stream by using benthic macroinvertebrates as bioindicators. We conducted the work on the Orienco stream in Lago Agrio in the province of Sucumbíos in the Northern Ecuadorian Amazon (NEA). The stream has become a sink of raw domestic sanitary wastewater from rural …

Viruses, Vaccines, And The Erotics Of Risk In Latinx Hiv Stories And Covid-19, Dr. Suzanne Bost

English: Faculty Publications and Other Works

In 2019, I published Shared Selves: Latinx Memoir and Ethical Alternatives to Humanism (University of Illinois Press), in which I discuss contagion as a metaphor for embracing our shared materiality with others. Six months later, during the Covid-19 pandemic, neighbors were crossing streets to avoid each other. Social distancing is, counterintuitively, asking us to view separation and seclusion as forms of solidarity. But how can we be solid if we are oriented against each other? Isolation itself has become contagious: sharing repulsion and rejection, measuring six feet of “social” distance from others. These spaces are made up of a variety …

Towards An Active Foveated Approach To Computer Vision, Dario Dematties, Silvio Rizzi, George K. Thiruvathukal, Alejandro Javier Wainselboim

Computer Science: Faculty Publications and Other Works

In this paper, a series of experimental methods are presented explaining a new approach towards active foveated Computer Vision (CV). This is a collaborative effort between researchers at CONICET Mendoza Technological Scientific Center from Argentina, Argonne National Laboratory (ANL), and Loyola University Chicago from the US. The aim is to advance new CV approaches more in line with those found in biological agents in order to bring novel solutions to the main problems faced by current CV applications. Basically this work enhance Self-supervised (SS) learning, incorporating foveated vision plus saccadic behavior in order to improve training and computational efficiency without …