Digital Commons Network^™

Structural Mechanism Of Nuclear Receptor Biased Agonism, Michelle Deanna Nemetchek

Graduate Student Theses, Dissertations, & Professional Papers

Nuclear receptors are a class of ligand-activated transcription factors that affect gene expression. Pharmaceutical drugs that target nuclear receptors make up (13%) of all therapeutics prescribed in the United States. Unlike signaling pathways, nuclear receptors have a wide variety of binding partners that can bind upon activation of a nuclear receptor to upregulate gene transcription. These binding partner proteins, called “coregulators”, are diverse in function. However, the determinants of their binding to nuclear receptors, and how binding to certain coregulators over others occurs, is not known.

In this work, we examine how ligands create a preference for nuclear receptors to …

The Genetic And Demographic Outcomes Of Mixed-Source Reintroductions Of Westslope Cutthroat Trout In Montana, Colter Austin Feuerstein

Graduate Student Theses, Dissertations, & Professional Papers

No abstract provided.

Quantification, Isolation, Characterization, And Biogeography Of Thermoacidophilic Bacteria From Mesophilic Soils, Margaux Karp

Cal Poly Humboldt theses and projects

Many thermoacidophilic bacterial species thrive in hot springs, fumaroles, and geothermally heated soils. These habitats are globally distributed but often small in size and located distantly from similar habitats, and therefore the biogeography of thermoacidophiles may be similar to island biogeography of plants and animals. Little is known about dispersal of thermoacidophiles. In this study I aimed to quantify, isolate, and characterize thermoacidophilic bacteria from non-permissive habitats. I also used genetic approaches to compare these isolates to thermoacidophilic bacteria from permissive habitats to provide insight to their biogeography.

To determine if I could enrich thermoacidophiles from non-permissive habitats, and if …

Does Having Siblings Affect Caretaking Responses To Infants?, Kaitlin Rose Duskin

Cal Poly Humboldt theses and projects

Infant facial cues affect a variety of caretaking-related responses in adults. These effects have primarily been explored as they relate to parental care, however infants receive care from others who are not their parents and it would be important for any caregiver, regardless of parental status, to respond to infant cues effectively. Because siblings often fulfill a caregiver role in the home, this study investigated whether having siblings, younger siblings in particular, influences the way in which adults respond to infant cues. Contrary to my predictions, the findings in this study indicate that having siblings does not influence how rewarding …

Evaluating Science Communication Efforts And Citizen Scientists' Knowledge Of, Attitude Toward, And Behavioral Intentions Related To The North American River Otter, Karlee D. Jewell

Cal Poly Humboldt theses and projects

Citizen Science (CS) and scientific visual, spatial, and graphic art projects have the potential to engage community members, provide opportunities for advances in scientific literacy, increase interest in science and local environmental knowledge, and elevate pro-environmental attitudes. CS depends upon public participation, and motivation for participation is varied, including participants’ desire to learn something new or contribute to science or scientific knowledge. An effective CS project will be rooted in an understanding of individuals’ motivations for participation, striving to meet those motivations, and effectively evaluating not only the scientific outputs of the project but also whether participants’ motivations are being …

Investigating The Genetic Diversity Of Immune Genes In Non-Native Populations Of American Bullfrogs (Rana Catesbeiana), Luisa Nereyda Segovia

Cal Poly Humboldt theses and projects

The American Bullfrog (Rana catesbeiana) is a highly invasive species that has successfully colonized habitats around the world. The genetic variability of immune genes within invasive populations, like that of bullfrogs, may contribute to how resistant a population is to pathogens. The objective of this project was to characterize the genetic diversity of an immune gene in invasive bullfrog populations in California to better understand how persistent these populations might be over time. To characterize immune gene variability, I isolated exon 2 of the Major Histocompatibility Complex (MHC) Class II Beta chain gene and a neutral mitochondrial marker, …

Course List - Fall 2022, Office Of Registrar

Semester Schedules and Information

No abstract provided.

Class Schedule - Spring 2022, Office Of The Registrar

Semester Schedules and Information

No abstract provided.

Textbook List - Spring 2022, Office Of Registrar

Semester Schedules and Information

No abstract provided.

Risk Of Developing Alzheimer's Disease And Related Dementias In Allhat Trial Participants Receiving Diuretic, Ace-Inhibitor, Or Calcium-Channel Blocker With 18 Years Of Follow-Up, Xianglin L Du, Lara M Simpson, Mikala C Osani, Jose-Miguel Yama, Barry R Davis

Faculty, Staff and Student Publications

BACKGROUND: There is no any large randomized clinical trial of antihypertensive drug treatment with 18-year passive follow-up to examine the risk of Alzheimer's Disease (AD) or Related Dementias (ADRD).

METHODS: Post-trial passive follow-up study of Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) participants in 1994-1998 by linking with their Medicare claims data through 2017 among 17,158 subjects in 567 U.S. centers who were free of ADRD at baseline on January 1, 1999. Main outcome was the occurrence of ADRD over 18 years of follow-up.

RESULTS: The 18-year cumulative incidence rates were 30.9% for AD, 59.2% for non-AD …

Blood Metabolites Predicting Mild Cognitive Impairment In The Study Of Latinos-Investigation Of Neurocognitive Aging (Hchs/So), Shan He, Einat Granot-Hershkovitz, Ying Zhang, Jan Bressler, Wassim Tarraf, Bing Yu, Tianyi Huang, Donglin Zeng, Sylvia Wassertheil-Smoller, Melissa Lamar, Martha Daviglus, Maria J Marquine, Jianwen Cai, Thomas Mosley, Robert Kaplan, Eric Boerwinkle, Myriam Fornage, Charles Decarli, Bruce Kristal, Hector M Gonzalez, Tamar Sofer

Faculty, Staff and Student Publications

INTRODUCTION: Blood metabolomics-based biomarkers may be useful to predict measures of neurocognitive aging.

METHODS: We tested the association between 707 blood metabolites measured in 1451 participants from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), with mild cognitive impairment (MCI) and global cognitive change assessed 7 years later. We further used Lasso penalized regression to construct a metabolomics risk score (MRS) that predicts MCI, potentially identifying a different set of metabolites than those discovered in individual-metabolite analysis.

RESULTS: We identified 20 metabolites predicting prevalent MCI and/or global cognitive change. Six of them were novel and 14 were previously reported as …

Knowledge, Attitude And Practice Related To Covid-19 Among People- A Descriptive Survey, Pramilaa R

Manipal Journal of Nursing and Health Sciences

Introduction: Corona virus can be deemed as one of the rapidly spreading viral infections. More than 200 countries in less than four months were infected. Findings of a study proved that insight of people in the community is remarkable to render care during pandemics. Characteristics that influence the people to adhere with sound healthy practices and desirable behaviors can be acquired by examining the level of awareness related to COVID-19 among people. Objectives: The objectives of the study were to assess knowledge, attitude and practice related to COVID-19 among people; correlate the knowledge, attitude and practice scores related to COVID-19 …

Enhancing Children's Achievement In Basic Science Using Library Electronic Books: A Case Of Simple Repeated Evaluation, Christian Ugwuanyi Phd

Library Philosophy and Practice (e-journal)

The 21^st century classrooms demand a lot from both the teachers and the learners due to the technological developments and demands in teaching and learning. These days, most parents buy their children (smart/android phones, tablets, or laptops without knowing the educational benefits of these gadgets in accessing online learning materials. The 21^st century technology has made the use of e-books very beneficial to the teaming population of learners who have access to the internet, but it is worrisome that there is a dearth of research on such issues in the Nigerian context. Thus, this research examined the effect …

Assessment Of Electronic Learning Usage In The Upper Basic Education French Language Curriculum: Implication For Evaluation Of Library And Information Science Resources, Kenneth Oma Eze Phd, Ekwutosi Monica Nnadi Phd, Christian Sunday Ugwuanyi Phd

Library Philosophy and Practice (e-journal)

People who work in a library and information science unit are passionate about making a positive difference in the world. Librarians are the people who work in this field, and their job is to bridge the gaps that exist between people, information, and technology. In today’s classroom instructional delivery, the use of electronic learning (e-learning) has become imperative. Thus, the study investigated the extent of implementation of e-learning in the upper basic education French language curriculum and its implication for the evaluation of Library and Information Science Resources. A sample of 370 students participated in the study. A 15–item questionnaire …

The Use Of Personal Digital Archiving For Effective Learning During Pandemic Covid-19, Naufal Ahmad Rijalul Alam

Library Philosophy and Practice (e-journal)

The Covid 19 pandemic that ravaged the world, particularly Indonesia, had a negative impact on aspects of learning, particularly for children aged three to six years in early childhood education. The implementation of distance learning disrupted the face-to-face learning model, which was supposed to be the primary medium for increasing children's knowledge and interest. In this regard, the role of parents is critical in ensuring that learning at home is effective and enjoyable. This study explores the using personal digital archiving (PDA) conducted by parents for effective learning during pandemic covid-19. By using a case study, this qualitative research took …

Comparative Study For Assessment Of Koha And Slims Features In Public Sector College Libraries Of Sindh, Aijaz Akhter Ahmedani, Khurram Shahzad, Rashid Siddique, Sara Khan

Library Philosophy and Practice (e-journal)

The core aim of the study was to assess KOHA and SLiMS features in Government College Libraries of Sindh. The objectives of the study were (a) to explore the reasons of Koha and SLiMS adoption and (b) to recognize the problems face by library professionals in the implementation of Koha and SLiMS. To meet the objectives, the study used a quantitative research approach and the survey method based on the questionnaire. Purposive sampling technique was used. The data was gathered only from those librarians who were working in Govt Colleges of Karachi, Hyderabad, and Sukkur and were using Koha or …

Non Reporting Of Sexual Victimization In Male Prisoners, Christopher Elliott

Walden Dissertations and Doctoral Studies

Sexual assault within prisons continues to occur despite federally mandated safety protocols and reporting procedures. Male inmates must also navigate the challenge of upholding societal gender norms to meet the ideal of hegemonic masculinity as identified in Gender Order Theory. Seven formerly incarcerated males were interviewed for this study. The interviews were designed to explore four relevant topical points which explored the roles that stereotypical/hegemonic masculinity traits play in the reporting of sexual victimization in males who were sexually victimized during incarceration. 2) The role gender roles stress/conflict play in the reporting of sexual victimization in males who were sexually …

Strategies Mental Health Managers Use To Reduce Direct Care Employee Turnover, Theresa Foster

Walden Dissertations and Doctoral Studies

Direct care professionals assist people with intellectual and developmental disabilities with health care services in the consumer's home, community based residential setting, hospitals, and vocational settings. The high turnover rate of direct care professionals working in mental health organizations may jeopardize many services, including administrative, medical, and provisions for the individuals they serve. Retaining direct care professionals is vital due to the expected demand for direct care jobs in the future. Grounded in Herzberg’s two-factor theory, this qualitative multiple case study explored leadership strategies managers from mental health organizations use to retain direct care professionals. Participants were eleven managers from …

Typhoid Fever Among Low-Income Women Living In Gujranwala, Pakistan., Tehmina S. Khan

Walden Dissertations and Doctoral Studies

Approximately 21 million individuals suffer from typhoid fever (TF) globally, and most outbreaks occur in Southeast Asia. The incidence of TF is high in Pakistan, particularly in low socioeconomic areas, and a new drug-resistant strain makes it difficult to control the spread of TF. There is a pressing need for up-to-date and accurate data regarding the attitudes, beliefs, and habits leading to the spread of TF infection among individuals living in low socioeconomic areas of Pakistan. This qualitative, phenomenological study was grounded in the health belief model and explored factors that influence the spread of TF among women of childbearing …

The Lived Experience Of Individuals Thinking About Food And Coping With Stress, Tobi Martin

Walden Dissertations and Doctoral Studies

Stress results in many people altering their eating patterns, often consuming food high in sugar and fat. Such behavior is a factor in the growing obesity epidemic and can potentially cause the development of chronic diseases, resulting in employment problems and billions of extra dollars spent on national health care programs. Researchers have focused on the concept of “emotional eating” while overlooking the overarching research question of this study, which was about exploring the experience of individuals using eating behavior as a coping mechanism to deal with stress. All responses were viewed through the lens of social cognitive theory. Interviews …

Strategies To Encourage Innovative Employee Performance In The Automotive Industry, Derek Mcelrath

Walden Dissertations and Doctoral Studies

The lack of innovative employee performance in the automotive industry leads to failure when it comes to the execution of organizational strategies. Senior automotive managers are concerned with innovative employee performance, as it has the potential loss of knowledge and the skillset by the employee. Grounded in Vroom’s expectancy theory, the purpose of this qualitative multiple case study was to explore strategies automotive managers use that encourage innovative employee performance. The participants were three senior automotive managers in Southeastern Michigan with at least three years of knowledge in employee work performance. Data were collected through semistructured interviews. Through thematic analysis, …

School Lunch Timing And Student Body Mass Index, Megan Monteith

Walden Dissertations and Doctoral Studies

Obesity continues to be a leading public health issue in the United States. Many chronic diseases are associated with obesity, including hypertension, diabetes, and several forms of cancer. There are multiple known contributing factors to obesity; however, historically, there has been little research focusing on time of day eating as a possible risk factor for obesity, especially childhood obesity. Childhood obesity is a significant risk factor for adult obesity. Obese children and adolescents are five times more likely to be obese in adulthood. The theoretical foundation for this study was the social ecological model. In this secondary correlational analysis using …

Emotional Intelligence And The Perceived Emotional Effects Of Cyberbullying In The Workplace, Madonna Navarro

Walden Dissertations and Doctoral Studies

Cyberbullying is a growing problem that has had a negative impact on the health and well-being of employees, which ultimately affects the success and productivity of organizations. In their four branch model of emotional intelligence, Mayer et al. stated that having the ability to perceive emotions, facilitate thought, understand emotions, and manage emotions was important in being able to regulate oneself and overcome adversities. This was the theoretical framework used for the study. The purpose of the current study was to determine what type of emotional effect priming emotional intelligence would have in the presence of perceived cyberbullying in the …

Social Work Participation In Living Donor Education To Organ Transplant Candidates, Mary Rzeszut

Walden Dissertations and Doctoral Studies

Living donor transplantation (LDT), despite its documented benefits, does not occur as often as deceased donor transplants (DDT). Transplant social workers are an integral part of the transplant interdisciplinary team and are well trained in conducting psychoeducation. This action research study involved examining social work practice challenges that transplant social workers experience that prohibit them from conducting effective LDT education. The study was guided by family problem solving theory, social cognitive theory and the Afrocentricity perspective to determine how transplant candidates and families can best learn information to discuss and recruit potential living donors. The research questions were about roles …

Why Some Cancer Patients Chose Fasting Instead Of, Or With, Conventional Treatments, Richard Alvin Sacks

Walden Dissertations and Doctoral Studies

Abstract Conventional cancer treatment consists of some combination of three therapies: chemotherapy, surgery and radiation. The purpose of this study was to understand why some individuals diagnosed with cancer elected to follow an alternative course of treatment, consisting of fasting on juices or water only rather than, or in addition to, conventional cancer treatment. The theory chosen to guide this study was the Markula Center for Applied Ethics framework for ethical decision making. Research questions were designed to understand the decision-making process of study participants in choosing fasting on juice or water only, rather than, or in addition to, the …

Law Enforcement Officers’ Lived Experiences With Male Victims Of Intimate Partner Violence, Selena Sanchez

Walden Dissertations and Doctoral Studies

Intimate partner violence (IPV) affects every race, culture, orientation, and sex. However, researchers focus largely on women as victims of IPV by men. Unfortunately, social and gender norms contribute to the focus on women as victims while adult heterosexual men remain underreported, underrepresented, and viewed predominantly as perpetrators. For example, 91% of men were arrested when IPV was reported, and officers responded to the call. This was referred to as gendered stigmatization. This transcendental qualitative phenomenological approach focused on the lived experiences of law enforcement officers who were called to the scene where IPV had occurred or was occurring, and …

Investigation Of The Relationship Between Interoception, Cognitive Flexibility, And Posttraumatic Growth, Sheaneh Sattari

Walden Dissertations and Doctoral Studies

Experiencing a traumatic event is a common occurrence within the world population. Researchers have found post-traumatic growth (PTG) occurs in individuals who grow, adapt, and change after experiencing a trauma. Through the lens of adaptation and neuroplasticity frameworks, cognitive flexibility and interoception can be regarded as forms of change and growth. However, scholarly literature was deficient in the investigation of the possible associations between interoception, cognitive flexibility, and PTG in individuals with histories of trauma. The purpose of this nonexperimental cross-sectional correlation study was to find the combined effect and relative importance of cognitive flexibility and interoception in accounting for …

The Lived Experience Of Older, Independent Residents During The Covid-19 Pandemic, Karen Graeb Stanley

Walden Dissertations and Doctoral Studies

The growing older population confronting the risks of the COVID-19 pandemic have a story to tell of their experiences that may influence the way society confronts future pandemics. Little research has been done on older adults in independent living communities and their experiences with the COVID-19 pandemic. This study aimed to fill that gap using the biopsychosocial model as a framework to guide the exploration of the research question addressing the lived experiences of older, independent residents during the COVID-19 pandemic. Using a basic qualitative analysis design, a purposive sample of 10 participants from a continuing care retirement community were …

Elementary Special Education Teachers’ Perception On Technology Adoption In The Shift To Online Learning, Samuel Sykes

Walden Dissertations and Doctoral Studies

Elementary special education teachers are required to provide online learning instruction to students with disabilities as schools are navigating through the COVID -19 pandemic with a lack of information as to how to do so successfully. The purpose of this basic qualitative study was to explore the perceptions of elementary special education teachers in a school district in the southeastern United States on their pedagogical and technology concerns regarding the shift to online learning for students with disabilities. This study’s conceptual framework was based on Roger’s diffusion theory and concerns-based adoption model. The research questions addressed elementary special education teachers’ …

Impact Of Poverty On Antibiotic Prescribing Rates In The United States Through Mediation Effects Of Underlying Health Conditions, Nato Tarkhashvili

Walden Dissertations and Doctoral Studies

Resistance to antibiotics among bacteria develops largely due to frequent use of antibiotics in human and animal medicine. Little is known about how patients’ socioeconomic factors, in conjunction with chronic health conditions, impact antibiotic prescribing rates in the United States. The research questions aimed to explore the relationship between poverty and antibiotic prescribing rates while also adjusting for confounders such as population aged ≥ 65, physician density, prevalence of obesity, diabetes, and chronic obstructive pulmonary disease (COPD). The relationships were evaluated using a quantitative, ecological study design using the ecosocial theory and mediation analysis of 2020 survey results provided by …