Digital Commons Network^™

Gabra5 Plays A Sexually Dimorphic Role In Pomc Neuron Activity And Glucose Balance, Zhou Pei, Yang He, Jonathan C Bean, Yongjie Yang, Hailan Liu, Meng Yu, Kaifan Yu, Ilirjana Hyseni, Xing Cai, Hesong Liu, Na Qu, Longlong Tu, Kristine M Conde, Mengjie Wang, Yongxiang Li, Na Yin, Nan Zhang, Junying Han, Camille Hs Potts, Nikolas A Scarcelli, Zili Yan, Pingwen Xu, Qi Wu, Yanlin He, Yong Xu, Chunmei Wang

Children’s Nutrition Research Center Staff Publications

Pro-opiomelanocortin (POMC) neurons are important for the regulation of body weight and glucose balance. The inhibitory tone to POMC neurons is mediated primarily by the GABA receptors. However, the detailed mechanisms and functions of GABA receptors are not well understood. The α5 subunit of GABAA receptor, Gabra5, is reported to regulate feeding, and we found that Gabra5 is highly expressed in POMC neurons. To explore the function of Gabra5 in POMC neurons, we knocked down Gabra5 specifically from mature hypothalamic POMC neurons using the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 strategy. This POMC-specific knock-down of Gabra5 did not affect …

Associations Of Prenatal Phthalate Exposure With Neurobehavioral Outcomes In 45- And 75-Month-Old Infants, Jenna L N Sprowles, Kelsey L C Dzwilewski, Francheska M Merced-Nieves, Salma M A Musaad, Susan L Schantz, Sarah D Geiger

Children’s Nutrition Research Center Staff Publications

Phthalates are ubiquitous endocrine-disrupting chemicals, and research indicates that prenatal exposure to some phthalates may affect neurodevelopment. In a prospective birth cohort study, five first-morning urine samples collected across pregnancy were pooled and the following phthalate biomarkers assessed: sum of di-(2-ethylhexyl) phthalate metabolites (ΣDEHP), sum of diisononyl phthalate metabolites (ΣDINP), sum of dibutyl phthalate metabolites (ΣDBP), sum of anti-androgenic metabolites (ΣAA), monoethyl phthalate (MEP), and sum of all phthalate metabolites (ΣAll). The Ages & Stages Questionnaires® (ASQ), a standardized parent-reported, age-adapted screening tool, measured communication, personal-social, problem solving, and motor domains in infants at 4.5 and 7.5 months (n = …

Tissue-Specific Mechanisms Of Bile Acid Homeostasis And Activation Of Fxr-Fgf19 Signaling In Preterm And Term Neonatal Pigs, Caitlin Vonderohe, Greg Guthrie, Barbara Stoll, Shaji Chacko, Harry Dawson, Douglas G Burrin

Children’s Nutrition Research Center Staff Publications

The tissue-specific molecular mechanisms involved in perinatal liver and intestinal farnesoid X receptor (FXR)-fibroblast growth factor 19 (FGF19) signaling are poorly defined. Our aim was to establish how gestational age and feeding status affect bile acid synthesis pathway, bile acid pool size, ileal response to bile acid stimulation, genes involved in bile acid-FXR-FGF19 signaling and plasma FGF19 in neonatal pigs. Term (n = 23) and preterm (n = 33) pigs were born via cesarean section at 100% and 90% gestation, respectively. Plasma FGF19, hepatic bile acid and oxysterol profiles, and FXR target gene expression were assessed in pigs …

Articulator Q2 2022

Metro Denver Dental Society Articulator Magazine

The MDDS Articulator magazine has been serving as the voice for Denver's dental community for over 100 years.

Distributed to approximately 2,000 dental professionals quarterly, the Articulator features local news, industry trends, practice management guidance, data-driven research and more. The award-winning publication is available to member dentists in both print and digital forms.

Issues include cover and feature articles alongside regular columns with regional news impacting the Metro Denver membership including editorial and perspectives columns, legal, association activities, component news, continuing education opportunities, and classifieds.

Enhancing Stakeholder Engagement To Achieve The Sustainable Management Of Free-Roaming Equids, Celeste Carlisle, Dan Adams

Human–Wildlife Interactions

Wild horse (Equus caballus) and burro (E. asinus; WHB) stakeholders in the American West are divergent in their views of free-roaming equids on public lands. Management authority for free-roaming equids on designated public lands was given to the Bureau of Land Management (BLM) and the U.S. Forest Service (USFS) in 1971 by U.S. Congress with the passing of the Wild and Free-Roaming Horses and Burros Act (WFRHBA). In 1976, the Federal Land Policy and Management Act (FLPMA) mandated the BLM to manage public lands for multiple-uses, which included livestock grazing, energy development, recreation, and timber harvest. …

Wyoming’S Wild Horse Ranch: History And Description Of A Socio-Ecological Experiment, Alex Sas-Jaworsky, John Derek Scasta

Human–Wildlife Interactions

The growing population of free-roaming horses (Equus ferus caballus) on western public rangelands has necessitated that federal agencies, such as the Bureau of Land Management (BLM) and U.S. Forest Service, develop novel approaches to curb growth including reproduction management. However, bureaucracy has hindered effective research and application of horse management on public lands and examples on private lands may present new solutions. Here we present the history and current population management strategy for the Wild Horse Ranch (WHR) located in southeastern Wyoming, USA, as an example of an ongoing private entity managing horses. Prior to 1985, this ~6,000-ha …

New Research And Wild Horse And Burro Management, David Jenkins

Human–Wildlife Interactions

In the United States, the Wild Free-Roaming Horses and Burros Act (WFRHBA) gave the Bureau of Land Management (BLM) and the U.S. Forest Service the statutory obligation to manage and protect free-roaming equids (i.e., wild horses [Equus ferus] and burros [E. asinus]) on designated management areas on public land. The WFRHBA was intended to ensure that wild horses and burros on the public lands exist in self-sustaining herds in perpetuity, alongside other congressionally mandated, multiple uses of public lands. The BLM recently published a strategic research plan for their wild horse and burro program. The research …

Feral Horses, Feral Asses, And Professional Politicians: Broodings From A Beleaguered Biologist, Vernon C. Bleich

Human–Wildlife Interactions

As a member of National Wild Horse and Burro Advisory Board, I gained insight into several aspects of feral equid management that previously had been somewhat cryptic. Foremost in my experience, though, was the dedication and professionalism of the board members with whom I served. During my tenure, the professional approach to management and the frustration faced by employees within the Horse and Burro Program became increasingly apparent. Further came the realization that the effectiveness of the board and program can be improved substantially, if (1) the board is provided the opportunity to rebut or counter incorrect or misleading information …

Healthy Western Lands: A Proposal For Healthy Rangelands, Wildlife, And Free-Roaming Horses And Burros, James S. Sedinger, Rebekah Stetson

Human–Wildlife Interactions

The Coalition for Healthy Nevada Lands, Wildlife and Free-roaming Horses (CHNL) is dedicated to proper management of free-roaming horses (Equus caballus) and burros (E. asinus) so rangelands are healthy, which benefits wildlife and the horses and burros themselves. The CHNL proposes the rapid reduction of horses and burros on designated public lands to achieve appropriate management levels (AML). After these reductions, the use of fertility control, supplemented with some gathers and adoption of gathered horses, should allow the Bureau of Land Management to economically maintain horse and burro populations at AML. The CHNL believes this approach …

Cover, Editorial Staff, Journal Information

Human–Wildlife Interactions

This includes the cover, editorial staff, and journal information.

Texas Hunters’ Perceptions Regarding The Acceptability Of Toxicants To Control Wild Pig Populations, Keith M. Carlisle, Sophie Mckee, Hailey E. Ellis, Lauren M. Jaebker, John M. Tomeček, Alan D. Bright, Rachael L. Connally, Maureen G. Frank, Stephanie A. Shwiff

Human–Wildlife Interactions

Wild pigs (Sus scrofa) are an invasive species in the United States. They damage agriculture, degrade water quality and ecological communities, and host a number of viruses, parasites, and bacteria transmissible to humans and animals. In states such as Texas, USA, where wild pigs cause extensive damage to agriculture and property, officials have considered allowing for the use of toxicants to control wild pig populations. To provide decision-makers with information regarding stakeholders’ perceptions of the use of toxicants to control wild pigs, we surveyed Texas hunters in 2019 to assess the level of acceptance of a hypothetical wild …

Mitigating Bighorn Sheep–Vehicle Collisions And Habitat Fragmentation With Overpasses And Adaptive Mitigation, Jeffrey W. Gagnon, Chad D. Loberger, Kari S. Ogren, Scott C. Sprague, Susan R. Boe, Raymond E. Schweinsburg

Human–Wildlife Interactions

As transportation infrastructure expands to accommodate increasing human population growth, wildlife–vehicle conflicts (WVCs) are a growing concern for motorist safety and wildlife populations. In the case of large ungulates, minimal information exists on successful mitigation of WVCs involving bighorn sheep (Ovis canadensis) and habitat fragmentation. Too address this void, we evaluated the effectiveness of 3 new wildlife overpasses, 3 culverts, 2 bridges, and ungulate exclusionary fencing as potential desert bighorn sheep (O. c. nelsoni; sheep) crossing opportunities along US Highway 93 in Arizona, USA. We evaluated sheep movements using global positioning system (GPS) radio-transmitter collars and …

Bear-Caused Human Fatalities In Yellowstone National Park: Characteristics And Trends, Kerry A. Gunther

Human–Wildlife Interactions

Three fatal bear (Ursus spp.) attacks in Yellowstone National Park (YNP), USA, from 2011 to 2015 were a catalyst for YNP managers to evaluate the circumstances of bear-caused fatalities as well as the bear safety messages it distributes to park visitors. I reviewed records of all fatal bear attacks that occurred in YNP from 1872 to 2018. Seven of the 8 fatalities were caused by grizzly bears (U. arctos horribilis). The per capita risk of being killed by a grizzly bear was 1 fatality for every 26.2 million park visits. Most fatal bear attacks in YNP involved …

Impact Of Covid-19 On Aviation-Wildlife Strikes Across Europe, Isabel C. Metz, Marta Giordano, Dionysios Ntampakis, Marianna Moira, Anneke Hamann, Rosanne Blijleven, Jürgen J. Ebert, Alessandro Montemaggiori

Human–Wildlife Interactions

Collisions between aircraft and wildlife (i.e., wildlife strikes) pose a serious threat toward the safety of aircraft, its crew, and passengers. The effects of COVID-19 related travel restrictions on wildlife strikes are unknown. With this study, we aim to address this information gap by assessing the changes of wildlife hazard management performance across European airports during the lockdown period (e.g., period of reduced operations and borders closure in spring 2020). We also sought to raise awareness of the importance of wildlife strike prevention in times of reduced operations. The objective of our study was to compare wildlife strike data before …

Symbiotic Relationship Between Local People And Asiatic Black Bears, Jangchuk Gyeltshen

Human–Wildlife Interactions

There are 8 species of bears (Ursidae) in the world; of these, 6 species are known to occur in Asia. However, in Bhutan, there are only 2 species: the Asiatic black bear (Ursus thibetanus) and the sloth bear (Melursus ursinus). The Asiatic black bear is legally protected by the Forest and Nature Conservation Act of Bhutan 1995. The bear is categorized as vulnerable by the International Union for Conservation of Nature and also included under Appendix I of the Convention on International Trade in Endangered Species. Human–bear conflicts are prevalent in Bhutan, especially at the village …

A Call For Ethical And Responsible Treatment Of Invasive Species By Recreational Anglers, Kevin A. Adeli

Human–Wildlife Interactions

Invasive species pose a prominent threat to global biodiversity, with aquatic ecosystems being particularly susceptible. In an effort to limit the spread of aquatic invasive species, numerous public awareness programs have been launched, and several regions have enacted “must-kill” angling regulations, which prohibit the live release of invasive fish species when captured. Many education programs, however, demonize invasive species and lack any instruction for humane euthanasia. This unbalanced approach has translated into widespread mistreatment of invasive species among recreational anglers. This piece addresses these concerns by discussing their significance and providing recommendations for how education programs can adopt a more …

Evaluation Of Virtual Screening Strategies For The Identification Of Γ-Secretase Inhibitors And Modulators, Alicia Ioppolo, Melissa Eccles, David Groth, Giuseppe Verdile, Mark Agostino

Research outputs 2022 to 2026

γ-Secretase is an intramembrane aspartyl protease that is important in regulating normal cell physiology via cleavage of over 100 transmembrane proteins, including Amyloid Precursor Protein (APP) and Notch family receptors. However, aberrant proteolysis of substrates has implications in the progression of disease pathologies, including Alzheimer’s disease (AD), cancers, and skin disorders. While several γ-secretase inhibitors have been identified, there has been toxicity observed in clinical trials associated with non-selective enzyme inhibition. To address this, γ-secretase modulators have been identified and pursued as more selective agents. Recent structural evidence has provided an insight into how γ-secretase inhibitors and modulators are recognized …

Digitalization In Food Supply Chains: A Bibliometric Review And Key-Route Main Path Analysis, Abderahman Rejeb, Karim Rejeb, Alireza Abdollahi, Suhaiza Zailani, Mohammad Iranmanesh, Morteza Ghobakhloo

Research outputs 2022 to 2026

Technological advances such as blockchain, artificial intelligence, big data, social media, and geographic information systems represent a building block of the digital transformation that supports the resilience of the food supply chain (FSC) and increases its efficiency. This paper reviews the literature surrounding digitalization in FSCs. A bibliometric and key-route main path analysis was carried out to objectively and analytically uncover the knowledge development in digitalization within the context of sustainable FSCs. The research began with the selection of 2140 articles published over nearly five decades. Then, the articles were examined according to several bibliometric metrics such as year of …

Identifying Effective Interventions To Promote Consumption Of Protein-Rich Foods From Lower Ecological Footprint Sources: A Systematic Literature Review, Rimante Ronto, Golsa Saberi, Gianna Maxi Leila Robbers, Stephanie Godrich, Mark Lawrence, Shawn Somerset, Jessica Fanzo, Josephine Chau

Research outputs 2022 to 2026

Addressing overconsumption of protein-rich foods from high ecological footprint sources can have positive impacts on health such as reduction of non-communicable disease risk and protecting the natural environment. With the increased attention towards development of ecologically sustainable diets, this systematic review aimed to critically review literature on effectiveness of those interventions aiming to promote protein-rich foods from lower ecological footprint sources. Five electronic databases (Medline, Web of Science, Scopus, Embase and Global Health) were searched for articles published up to January 2021. Quantitative studies were eligible for inclusion if they reported on actual or intended consumption of protein-rich animal-derived and/or …

Strength Training In Swimming, Klaus Wirth, Michael Keiner, Stefan Fuhrmann, Alfred Nimmerichter, Gregory G. Haff

Research outputs 2022 to 2026

This narrative review deals with the topic of strength training in swimming, which has been a controversial issue for decades. It is not only about the importance for the performance at start, turn and swim speed, but also about the question of how to design a strength training program. Different approaches are discussed in the literature, with two aspects in the foreground. On the one hand is the discussion about the optimal intensity in strength training and, on the other hand, is the question of how specific strength training should be designed. In addition to a summary of the current …

A Myc-Znf148-Id1/3 Regulatory Axis Modulating Cancer Stem Cell Traits In Aggressive Breast Cancer, Mijeong Kim, Manjot Singh, Bum-Kyu Lee, Moira Hibbs, Kirsty Richardson, Lesley Ellies, Larissa Wintle, Lisa M. Stuart, Jenny Y. Wang, Dominic C. Voon, Pilar Blancafort, Jianlong Wang, Jonghwan Kim, Peter J. Leedman, Andrew J. Woo

Research outputs 2022 to 2026

The MYC proto-oncogene (MYC) is one of the most frequently overexpressed genes in breast cancer that drives cancer stem cell-like traits, resulting in aggressive disease progression and poor prognosis. In this study, we identified zinc finger transcription factor 148 (ZNF148, also called Zfp148 and ZBP-89) as a direct target of MYC. ZNF148 suppressed cell proliferation and migration and was transcriptionally repressed by MYC in breast cancer. Depletion of ZNF148 by short hairpin RNA (shRNA) and CRISPR/Cas9 increased triple-negative breast cancer (TNBC) cell proliferation and migration. Global transcriptome and chromatin occupancy analyses of ZNF148 revealed a central role in inhibiting cancer …

Exploring Food Supply Chain Trends In The Covid-19 Era: A Bibliometric Review, Abderahman Rejeb, Karim Rejeb, Andrea Appolloni, Mohammad Iranmanesh, Horst Treiblmaier, Sandeep Jagtap

Research outputs 2022 to 2026

Recently, the food supply chain (FSC) has been severely disrupted due to the COVID-19 pandemic, putting the vital flow of food products from farmers and producers to the ultimate consumers at risk. Furthermore, due to the pandemic, several food organizations have been prompted to rethink their strategies for the future. Although the literature on FSC research in the COVID-19 era is increasing, no attempt has been made to summarize this stream of research using bibliometric techniques. This paper fills this knowledge gap and looks at the current scholarly discourse around the FSC and COVID-19. Applying bibliometric techniques, 287 journal articles …

Maya-Kwobabiny: Re-Embedding Language At Kepa Kurl, Western Australia, Clint Bracknell, Amy Budrikis, Roma Yibiyung Winmar

Research outputs 2022 to 2026

This paper describes a Nyungar language revitalisation project in the southern region of Western Australia conducted in partnership between a university research team and the Esperance Tjaltjraak Native Title Aboriginal Corporation. It discusses how linguistic analysis of historical Nyungar documentation was essential to addressing community aims of re-embedding the language into the community, developing and using pedagogical resources, and exploring new domains for language use. In particular, this paper focuses on the community’s desire for the reclamation of a dialectal flavour of Nyungar that is distinctive to the Esperance region, and the factors contributing to a successful partnership between the …

World In Strife – Returning To The Humanities, Clive Barstow, Jill Felicity Durey

Research outputs 2022 to 2026

The background of this article relates to a long, ongoing attenuation of the Humanities within universities. The problem is the continuing sidelining of the Humanities in university teaching and research funding. If this attenuation and sidelining continue, the world will be a much more cruel and dangerous place, as there will be no moral or ethical check on scientific and technological developments from a humanitarian perspective. This article discusses some of the fears, hopes and criticisms of the Humanities expressed by scholars around the globe, from western democracies including Australia, as well as from middle-eastern and eastern autocracies. The article …

Do Bird Communities Differ With Post-Fire Age In Banksia Woodlands Of South-Western Australia?, Robert A. Davis, Leonie E. Valentine, Michael D. Craig

Research outputs 2022 to 2026

Prescribed fire is a widespread management practice in fire-prone ecosystems that can have significant effects on fauna. To inform the development of appropriate prescribed burning regimes, we explored bird responses to time since fire in threatened Banksia woodlands in south-western Australia. We used area searches to estimate bird densities on 20 plots ranging from 1 to 26 years post fire. Fire had no significant effect on the overall bird community or any foraging guilds and there was no clear post-fire succession. Of the 26 frequently occurring species analysed, only two showed responses to fire, with yellow-rumped thornbills more abundant in …

5-Ht2 Receptor Antagonism Reduces Human Motoneuron Output To Antidromic Activation But Not To Stimulation Of Corticospinal Axons, Jacob R. Thorstensen, Janet L. Taylor, Justin J. Kavanagh

Research outputs 2022 to 2026

The intrinsic electrical properties of motoneurons strongly affect motoneuron excitability to fast-acting excitatory ionotropic inputs. Serotonin (5-HT) is a neurochemical that alters the intrinsic properties of motoneurons, whereby animal models and in vitro experiments indicate that 5-HT increases motoneuron excitability by activating 5-HT2 receptors on the somato-dendritic compartment. In the current study, we examined how antagonism of the 5-HT2 receptor affects motoneuron excitability in humans. We hypothesised that motoneuron excitability would be reduced. The 5-HT2 antagonist cyproheptadine was administered to 10 healthy participants in a double-blinded, placebo-controlled, crossover trial. Electrical cervicomedullary stimulation was used to deliver a synchronised excitatory volley …

Epidemiology Of ∆8thc-Related Carcinogenesis In Usa: A Panel Regression And Causal Inferential Study, Albert Stuart Reece, Gary Kenneth Hulse

Research outputs 2022 to 2026

The use of ∆8THC is increasing at present across the USA in association with widespread cannabis legalization and the common notion that it is “legal weed”. As genotoxic actions have been described for many cannabinoids, we studied the cancer epidemiology of ∆8THC. Data on 34 cancer types was from the Centers for Disease Control Atlanta Georgia, substance abuse data from the Substance Abuse and Mental Health Services Administration, ethnicity and income data from the U.S. Census Bureau, and cannabinoid concentration data from the Drug Enforcement Agency, were combined and processed in R. Eight cancers (corpus uteri, liver, gastric cardia, breast …

Injury Surveillance In Community Cricket: A New Inning For South Africa, Benita Olivier, Oluchukwu L. Obiora, Candice Macmillan, Caroline Finch

Research outputs 2022 to 2026

Published injury rates amongst elite and club-level youth cricketers highlight the need to implement injury risk-reducing strategies amongst the youth cricketing population. Data from sports injury surveillance systems are a prerequisite for the development and evaluation of strategies to reduce injury risk. Therefore, collecting injury surveillance data is a positive move towards reducing injuries in cricket. In South Africa, a systematic, standardised, evidence-informed injury surveillance system currently does not exist for community levels of play, namely, in cricket-playing high schools and cricket clubs. Although injury surveillance systems exist at elite levels, the obvious differences in elite versus community cricket settings …

Psychological Distress And Quality Of Life In Asymptomatic Adults Following Provision Of Imaging Results For Prevention Of Cardiovascular Disease Events: A Scoping Review, Reindolf Anokye, Ben Jackson, James Dimmock, Joanne M. Dickson, Lauren C. Blekkenhorst, Jonathan M. Hodgson, Joshua R. Lewis, Mandy Stanley

Research outputs 2022 to 2026

Aims Psychological distress and changes in health-related quality of life (HRQoL) may occur after screening for disease. Reporting outcomes related to potential benefits and harms of screening is a key recommendation in the guidelines for reporting high-quality trials or interventions. However, no reviews have directly investigated outcomes related to psychological distress and/or changes in HRQoL following imaging assessment of cardiovascular risk and communication of cardiovascular findings to asymptomatic adults. A scoping review was conducted to map research on psychological distress and/or HRQoL following screening. Methods and results

Six electronic databases (MEDLINE, PsychINFO, Social Work Abstracts, Psychology and Behavioural Sciences Collection, …

Addressing Filicide In Ghana: Linking Cultural Understanding With The Law Against Filicide. Does The Law Work?, Alhassan Abdullah, Margarita Frederico, Felix Mensah, Hajara Bentum, Yihang Wang, Jennifer Litela Asare

Research outputs 2022 to 2026

Introduction: Consistent with international promulgation on the criminalization of filicide, Ghana’s Children’s Act 1998 (560) and the Criminal Justice Act criminalizes any form of torture against children. Yet, perpetrators of filicide in Ghana may go unpunished due to the beliefs in cultural norms that justify filicide acts. The cultural narratives of filicide can impede on the application and effectiveness of the laws of filicide. Method: The study employed a vignette approach to explore the views of 19 adults, who were parents between 69 years of age and 30 years of age, in rural and urban Ghana on the laws of …