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Anthracyclines Attenuate The Nrf1-Mediated Bounce-Back Response, Bader Albalawi

Theses and Dissertations

Proteasome inhibitors, such as carfilzomib, are FDA-approved to treat multiple myeloma and mantle cell lymphoma. Unfortunately, proteasome inhibitors have only produced clinically significant results in patients with hematologic cancers, despite their predicted pan-cancer utility, and even hematologic cancer types frequently show intrinsic and acquired resistance.

One proposed mechanism responsible for the proteasome inhibitors' shortcomings is the NRF1-mediated bounce-back response. Identification of drugs that can potentiate the action of proteasome inhibitors could overcome resistance in patients with hematologic cancers and expand proteasome inhibitors' use to treat solid tumors. Our previous studies have identified anthracyclines as potential compounds that interfere with the …

Postmaterialism And Corporate Tax Avoidance, Yujia Cui, Jiwei Wang, Kangtao Ye

Research Collection School Of Accountancy

This paper explores how postmaterialism culture influences corporate tax avoidance behavior. Using a proprietary dataset of China tax audits, we find that firms owned by investors from countries with higher postmaterialism values are less likely to engage in tax avoidance behavior in China. In addition, we find some evidence that the negative association between postmaterialism and tax avoidance is more pronounced when tax enforcement is stronger, indicating that national culture and formal institutions act as complements. To check the external validity of our main results, we further use a cross-country sample from 21 countries over 22 years. The evidence from …

Realistic Virtual Human Character Design Strategy And Experience For Supporting Serious Role-Playing Simulations On Mobile Devices, Sindhu Kumari

Browse all Theses and Dissertations

Promoting awareness of social determinants of health (SDoH) among healthcare providers is important to improve the patient care experience and outcome as it helps providers understand their patients in a better way which can facilitate more efficient and effective communication about health conditions. Healthcare professionals are typically educated about SDoH through lectures, questionaries, or role-play-based approaches; but in today’s world, it is becoming increasingly possible to leverage modern technology to create more impactful and accessible tools for SDoH education. Wright LIFE (Lifelike Immersion for Equity) is a simulation-based training tool especially created for this purpose. It is a mobile app …

Detection Of Benzotriazole And Related Analogues In Surface Samples Collected Near An Ohio Airpark, Clara Leedy

Browse all Theses and Dissertations

Benzotriazoles are a class of contaminant of emerging concern which are commonly used as anticorrosive agents in aircraft deicer and anti-icing fluids (ADAFs). The analogues 1H-benzotriazole (BTZ), 4-methyl-1H-benzotrizole (4m-BTZ), and 5-methyl-1H-benzotriazole (5m-BTZ) are commonly found in environmental occurrence together. The two methylated isomers, collectively known as tolytriazole (TTZ), have different toxicity and stability. These contaminants are highly water soluble and resistant to biodegradation, making them persistent through water treatment. Benzotriazoles have been detected worldwide; this investigation focuses on monitoring three sites near a small airpark in Wilmington, Ohio. Two sites that receive runoff from the airpark, Lytle Creek and Indian …

Heightened Levels Of Microvesicle Particles Resulting From Combination Of Ethanol And Thermal Burn Injury, Chad Alan Brewer

Browse all Theses and Dissertations

Ethanol (EtOH), in combination with thermal burn injury, is a clinically significant problem resulting in an increase in morbidity and mortality due to acute multi-organ toxicity from excess systemic cytokine release. This intoxicated thermal burn affects close to 50% of the total numbers of hospital-admitted burn patients and currently has no standard treatment. However, using in vitro cellular and in vivo murine models, our group has provided data implicating the augmented production of the lipid mediator Platelet-activating factor (PAF) in keratinocytes in response to intoxicated thermal burn injury in the subsequent pathology. Of importance, our group has demonstrated that activation …

Vertebrate Assemblages Of The Skelley Limestone (Conemaugh Group : Carboniferous, Gzhelian) In Noble And Muskingum Counties, Ohio, Daniel Austin Cline

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Three outcrops of the Gzhelian-aged Skelley Limestone (Casselman Formation, Conemaugh Group) were explored for vertebrate macrofossils and vertebrate microremains. The purpose of this exploration was to construct a better ecological history of the marine communities in the Late Pennsylvanian of eastern Ohio. Bulk limestone samples were collected, washed with acid, sieved and the resulting residues produced 21 distinct taxa of near-shore marine vertebrates. Osteichthyans were represented by an unknown palaeonisciform, an unknown platysomid, and an unknown palaeoniscoid. Holocephalians were represented by symmoriforms, helodontiforms, cochliodontiforms, and petalodontiforms. Elasmobranch groups included ctenacanthiforms and euselachians which contained representatives of hybodontiforms, protacrodontiforms, and neoselachians. …

Development Of Enhanced User Interaction And User Experience For Supporting Serious Role-Playing Games In A Healthcare Setting, Mark Lee Alow

Browse all Theses and Dissertations

Education about implicit bias in clinical settings is essential for improving the quality of healthcare for underrepresented groups. Such a learning experience can be delivered in the form of a serious game simulation. WrightLIFE (Lifelike Immersion for Equity) is a project that combines two serious game simulations, with each addressing the group that faces implicit bias. These groups are individuals that identify as LGBTQIA+ and people with autism spectrum disorder (ASD). The project presents healthcare providers with a training tool that puts them in the roles of the patient and a medical specialist and immerses them in social and clinical …

Ahr-Mediated Transcriptional Regulation Of The Human Immunoglobulin Hs1.2 Enhancer, Sydney White

Browse all Theses and Dissertations

The 3'IGHRR is thought to be responsible for the transcription of the immunoglobulin heavy chain (IGH) gene locus, which is essential for the production of antibodies. The human 3’IGHRR, which is duplicated in humans, contains the hs3, hs4, and hs1.2 enhancers. Additionally, the hs1.2 enhancer is polymorphic in humans and consists of a 53 bp invariant sequence that can be repeated one to four times. Previous experiments in a mouse and human B-cell line model have shown that the high affinity AhR ligand and environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can induce hs1.2 enhancer activity in an AhR-dependent manner. The AhR is …

Expression Of Sars Cov2 Receptors Influenced Upon Cytokine Polarizations (Il-4 And Ifnγ) In Hemangioendothelioma Cells, Chandra Lekha Koopari

Browse all Theses and Dissertations

Endothelial cells are distinct multifunctional cells with essential metabolic and synthetic roles along with their ability to function as selective permeability barrier. Endothelial cells (ECs), the major component of blood vessels, essentially interact directly yet differently with inflammatory cytokines. ECs are well recognized to be polarized cells, but little is known about the potential function of inflammatory mediators. Covid 19 may have long-term health effects on par with chronic illnesses. Vascular inflammatory disease and coagulopathy linked to COVID-19 are exacerbated by endothelial cell (EC) dysfunction. SARS-CoV-2 enters the host cell through the Angiotensin Converting Enzyme 2 (ACE2) receptor and primes …

Examining Ayahuasca Constituents At 5-Ht2a Receptors In Search Of Antidepressant Action, Jeremy D. Rolquin

Theses and Dissertations

Recently, it has been reported that ligands of the 5-HT_2A receptor can have drastic and fast-acting efficacy towards a number of different mental health disorders, such as depression and anxiety. A mixture of Amazonian plants calledayahuasca contains multiple compounds which have been shown to interact with the serotonergic system, and the 5-HT_2Areceptor in particular.

The structurally similar compounds (DMT, harmine, harmaline, and tetrahydroharmine) found in ayahuasca were examined for differences in their physiochemical properties that might contribute to their binding affinity for the 5-HT_2Areceptor. 3D Molecular modeling and docking studies of these compounds were …

The Role Of Human Dopamine Transporter Threonine 261 And Serine 262 In Amphetamine Regulation Of Transporter Function And Surface Expression, Sina Abdollahi

Theses and Dissertations

Amphetamine (AMPH) has been used clinically and recreationally around the world for years. A 2021 study reports a 67.5% rise in AMPH use from 2010-2017 across all fifty states. Study also shows that 30% of patients with AMPH-induced psychosis end up with primary psychosis over time. AMPH works by inhibiting monoamine (Norepinephrine (NE), Serotonin (5-HT), and Dopamine (DA) reuptake followed by triggering transporter mediated monoamine release and consequently increases monoamine concentrations in extracellular synaptic space. AMPH also works as a substrate for monoamine transporters, enters the neuron, and once its inside the neuron, it will prevent the storage of monoamines …

Identification Of The New Synthetic Opioid Bucinnazine And Its Metabolites Using Liquid Chromatography Tandem Mass Spectrometry (Lc-Ms/Ms), Karissa N. Resnik

Master of Science in Forensic Science Directed Research Projects

In the past 20 years, the rate of opioid use increased drastically in the United States. The country has experienced an enormous number of deaths caused by opioid overdose, opioid use disorder (OUD), as well as other harms as a consequence of the high numbers of opioid prescriptions. Fentanyl, a well-known synthetic opioid, has been a contributor to the opioid crisis since 2013 due to its popularity in clinical and illicit use. It has a high potency, which makes it an effective analgesic but a dangerous illicit substance. A new synthetic opioid, bucinnazine, has recently become a new black-market opioid …

Optimization Of A Microfluidic Device For Cell Capture Using Optical Trapping, Samantha C. Pagel

Master of Science in Forensic Science Directed Research Projects

Biological mixtures which result from evidence produced in sexual assault cases are one of the most common types of mixtures observed in forensic biology casework and have contributed to evidence backlogs across the country. In the forensic community, this has highlighted the need for a more efficient cell separation method at the beginning of the DNA analysis workflow than the currently accepted method. One promising novel front-end cell separation technique is optical trapping. In heterogeneous mixtures, optical tweezers have been demonstrated to manipulate and isolate cells of interest from other cell types.

For this research, a range of 5 to …

Bowling Green Main Street Revitalization Plan, Amy Guzulaitis

Master of Urban and Regional Planning Capstone Projects

The Town of Bowling Green is a historic, rural community located in Caroline County, Virginia. The Town is the pride of residents who enjoy the community and small town nature of the area. The Town currently has a small arts business cluster and sought ways to use that, as well as the Main Street Method, as a basis for spurring revitalization in the Town. Research Methods & Findings Today, the Town of Bowling Green faces challenges to its future growth and development due in part to the small market size available. Demographic indicators from ESRI Business Analyst show that Bowling …

Growing Small: Citizen Preferences For New Development In Highland County, Virginia, And The Town Of Monterey, Charles F. Wilson

Master of Urban and Regional Planning Capstone Projects

“Growing Small: Citizen Preferences for New Development in Highland County, Virginia and the Town of Monterey” is a plan by Charles Wilson for Highland County (“Highland”) as they reconsider the future of the Town of Monterey (“Monterey”). Highland is a rural county in western Virginia at the intersection of U.S. Routes 250 and 220. In the Summer of 2021, a new Family Dollar was issued permits to demolish an historical lodging facility and construct a new store—just a few buildings away from an existing Dollar General. This was not without controversy, but ultimately prompted reflection amongst community members for how …

The Mechanisms Of Axon Initial Segment Alteration Due To Disrupted Glucose Metabolism: A Potential Link To Cognitive Impairment, Duc Van Minh Nguyen

Browse all Theses and Dissertations

Cognitive impairment is a serious global health issue due to its widely complicated pathologies that are linked to many diseases, including type 2 diabetes. Yet, detailed mechanisms of cognitive impairment associated with type 2 diabetes are unknown. Evidence suggests type 2 diabetes is associated with disrupted glucose metabolism, elevated methylglyoxal, and axon initial segment (AIS) shortening. Subtle changes of AIS could significantly contribute to neuronal dysfunction in neurological diseases (e.g., cognitive impairment). Utilizing in vitro dissociated mouse cortical cultures, we initially discovered elevated methylglyoxal shortens the AIS length of the immunofluorescent marker AnkyrinG (Griggs et al., 2021). This thesis further …

Effects Of Lipin1 Deficiency & Restoration In The Dystrophic Diaphragm, Alexandra Brown

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Duchenne Muscular Dystrophy (DMD) is an X-linked recessive disorder that is characterized by severe and progressive muscle wasting (Venugopal & Pavlakis, 2021). This disease is caused by a mutation in the largest known human gene which encodes the protein, dystrophin (Gao & McNally, 2015). Dystrophin connects the inner cytoskeleton to the extracellular matrix and is critical for maintaining the structural stability of muscle cells during contraction (Venugopal & Pavlakis, 2021). Mutations to the dystrophin gene result in myocyte membrane instability, contributing to the structural deterioration of the muscle tissue (Venugopal & Pavlakis, 2021). Progressive muscle degeneration and the replacement of …

Analytical-Based Methods For Studying The Interaction Of Human Red Blood Cells With Noble Metal Nanoparticles, Praveen Kumar Alla

Browse all Theses and Dissertations

With the advent of nanotechnology, the potential applications of nanoscale gold in medicine have expanded substantially. Gold’s therapeutic and toxic properties have been widely studied; however, little is known regarding gold’s contribution to oxidative stress in red blood cells (RBCs). This is especially true for recently designed large (L) gold nanorods (GNRs), which possess unmatched theranostic capabilities. Here, we report on the effect of LGNRs at the level of cellular function, and particularly on ion transport and the glutathione (GSH) concentration in human (H) RBCs. Gold has been hypothesized to effectively react with RBCs sulfhydryl groups, thereby causing depletion of …

Federalism By Deception: The Implied Limits On Congressional Power, Bryan K. Fair

Articles

The purpose of this Article is to lay bare federalism by deception and the theory of implied limits on federal power. Other scholars have recently noted the rise of anti-federalist viewpoints in modern cases. I go a step further to demonstrate how Supreme Court Justices have embraced anti-federal ideology, but have cited Federalist sources, including Marshall, to announce unenumerated limits on federal legislative power.

What Is Consumer Protection For?, Luke Herrine

Articles

When law and economics barreled its way into consumer protection scholarship two score years ago, it brought with it the consumer sovereignty framework: an approach to analysis in which actual markets are compared to an ideal market in which consumers optimize exogenous welfare functions by choosing between optimally competitive sellers. Even after two decades of behavioralist critique and even with increasingly critical perspectives taking root since the Global Financial Crisis, this consumer sovereignty ideal continues to serve as both a descriptive and normative baseline for consumer protection scholarship.

This Article argues that it is time to reconsider the consumer sovereignty …

Bringing Predictability To The Chaos Of Punitive Damages, Benjamin Mcmichael, W. Kip Viscusi

Articles

Punitive damages remain unique in the American legal system. Awarded in the civil context with none of the protections offered in criminal law, courts levy punitive damages to punish and deter. The Supreme Court of the United States has clearly stated that courts may only seek to achieve these two goals when imposing punitive damages. A closer reading of the Court's punitive damages jurisprudence, however, reveals another goal that has largely been ignored: predictability. Unlike punishment and deterrence, predictability is not a purpose for which to award punitive damages. Instead, the Court requires that, when awarded, the level of punitive …

Contracts In The Age Of Smart Readers, Yonathan A. Arbel, Becher, Shmuel I.

Articles

No abstract provided.

The Spicy Girls: Writings On The Lived Experiences Of Latinas As The Exotic "Other.", Nina M. Lopez

Honors Undergraduate Theses

The Other in mainstream U.S. society—in this case, the Latino Other—faces oppressive forces in the journey to find belonging. Latinos are marked by stereotypes, regardless of whether such stereotypes have a factual foundation. Latinas specifically are labeled as submissive servants, maids, or nannies. On the other end of the spectrum, Latinas are exotic and enticing sexual beings that must satisfy white men’s fetishes and lechery. Through this thesis, I will explore what Latina women face as an Other that is paradoxically both rejected and desired and evokes aversion as well as awe. In this creative thesis, in creative nonfiction, poetry, …

How Screendance Embraces What Cannot Be Done On Stage, Maya Reddy

Theatre and Dance Honors Projects

Due to the recentness of the field of dance filmmaking, little research exists on the difference between dance films designed to be watched as films (referred to as screendance) and dance videography (videos of performances created to be viewed by a live audience). This paper contends that what separates screendance from dance videography is the unique appeal screendance has for the viewer. Through the use of instantaneous location changes or inaccessible locations, unusual camera perspectives (such as a birds’ eye shot) that allow the viewer to feel as if they or the dancers are defying gravity, and technology-mediated changes to …

The Benefits Of Integrating Statutory Construction And Analysis In A First-Year Legal Writing Course, Lauren E. Sancken, Mireille Butler

Articles

Teaching statutory analysis to first-year law school students not only reinforces important principles of legal analysis and writing (from gaining a better understanding of the hierarchy of legal authorities to continuing to practice IRAC/CRAC methods of organization), but it also prepares students better for the actual practice of law.

Judean Piracy, Judea And Parthia, And The Roman Annexation Of Judea: The Evidence Of Pompeius Trogus, Kenneth Atkinson

Faculty Publications

Pompey the Great’s 63 BCE conquest of the Jewish kingdom known as the Hasmonean State has traditionally been viewed as an inevitable event since the Roman Republic had long desired to annex the Middle Eastern nations. The prevailing consensus is that the Romans captured the Hasmonean state, removed its high-priest kings from power, and made its territory part of the Republic merely through military force. However, Justin’s Epitome of the Philippic Histories of Pompeius Trogus is a neglected source of new information for understanding relations between the Romans and the Jews at this time. Trogus’s brief account of this period …

I, Jill Alexander, American Girl Revolutionary, Taraneh M. Haghanikar

Faculty Publications

Analyzing the insider-outsider continuum in Remembrance of the Sun (1986, 2011) by Kate Gilmore, the purpose of this paper is to reveal different levels of being a female outsider protagonist moving along the insider-outsider continuum, maintaining an outsider voice, and at the same time developing an insider perspective. Remembrance of the Sun is a historical fiction authored by an outsider and set in 1978, one year before the Islamic revolution in Iran. After moving from New England to Tehran, Jill, a seventeen-year-old American girl, struggles to adjust to an unfamiliar lifestyle. However, her experience becomes a story of love and …

Perspectives On New Wilderness Area Designations In Michigan's Upper Peninsula, Olivia Joy D. Ghormley

Dissertations, Master's Theses and Master's Reports

The Wilderness Act of 1964 designated certain areas denoted as wilderness in the United States of America for the sake of preservation and conservation. In the state of Michigan, 16 designated wilderness areas currently exist, and the Environmental Law and Policy Center (ELPC) is advocating for the addition of four new wilderness designations. The addition of these areas would add about 51,000 acres of federally recognized wilderness areas to the Upper Peninsula of Michigan. This paper aims to understand public attitudes and political support or opposition to these new wilderness designations among residents and visitors of the Upper Peninsula of …

Machine Learning-Driven Surrogate Models For Electrolytes, Tong Gao

Dissertations, Master's Theses and Master's Reports

We have developed a lattice Monte Carlo (MC) simulation based on the diffusion-limited aggregation model that accounts for the effect of the physical properties of ionic liquids (ILs) on lithium dendrite growth. Our simulations show that the size asymmetry between the cation and anion, the dielectric constant, and the volume fraction of ILs are critical factors to significantly suppress the dendrite growth, primarily due to substantial changes in electric-field screening. Specifically, the volume fraction of ILs has the optimal value for dendrite suppression. The present simulation method indicates potential challenges for the model extension to macroscopic systems. Therefore, we also …

Decomposition Of Organic Matter Above And Below Dams, Olivia Muntz

Senior Honors Theses and Projects

Dams produce hydroelectric power and control flooding, but they also cause negative ecological consequences such as habitat fragmentation and altered water quality. The goal of this study was to determine whether dams alter rates of organic matter decomposition. Decomposition rates in impoundments and in free-flowing sections of the Huron River were measured using the cotton strip assay. We hypothesized that if water temperature is the main driver of decomposition rates, then higher rates of decomposition would be expected behind dams due to anticipated warmer water temperatures in the impoundment. If oxygen concentrations are a main driver of decomposition rates, lower …