Digital Commons Network^™

Simulated Intimacy, But Real Connection: Perceived Reciprocity And Romantic Closeness Make Otome Fun To Play, Nicholas Bowman, Elena Yifei Zhao

Media Studies - All Scholarship

Otome games offer players the opportunity to form romantic relationships with NPCs. Drawing on Social Exchange Theory, we proposed that, in the context of otome game, reciprocity enhances the sense of romantic closeness with NPCs, which in turn lead to greater enjoyment and appreciation. Survey data from 293 Chinese otome players supported the model, suggesting that at least one of the reasons that otome gaming is so entertaining is that they provide players with relationships that those players engage as if they were authentically social. Descriptive results revealed high reciprocity scores and strong romantic connection with NPCs, which players feeling …

Stimulus-Driven Cerebrospinal Fluid Dynamics Is Impaired In Glaucoma Patients, Ji Won Bang, Carlos Parra, Kevin Yu, Hyun Seo Lee, Gadi Wollstein, Joel Schuman, Kevin Chan

Wills Eye Hospital Papers

Cerebrospinal fluid (CSF), partly driven by sensory stimulation, is crucial for maintaining homeostasis and clearing metabolic waste. Whether such stimulus-driven CSF flow is disrupted in age-related neurodegenerative diseases of the visual system remains unclear. This study examined the CSF flow during visual stimulation in glaucoma patients and healthy older adults using functional magnetic resonance imaging. In glaucoma, CSF inflow becomes progressively decoupled from the visually evoked blood-oxygenation-level-dependent (BOLD) response. Specifically, the characteristic stimulus-locked CSF patterns, which decrease after stimulus onset and increase after offset, diminish with disease severity. Mediation analysis suggests this flattened CSF pattern is driven by a flatter …

Assessing The Effectiveness Of The One Paleopathology Workshop, Julianne R. Stamer, Mario Apata Mamani, Bernardo Arriaza, Robin Bendrey, Kelly Blevins, Tessa Campbell, Nicole Gottdenker, Rebecca Gowland, Haagen Klaus, Carina Marques

Anthropology Faculty Publications

Background and objectives: One Paleopathology is a novel concept in Paleopathology that extends the One Health paradigm into the past. A workshop at the University of Durham, UK, was held prior to the 2024 International Society for Evolution, Medicine, and Public Health (ISEMPH) meeting, firstly to define and expand the concept of One Paleopathology and secondly to generate transdisciplinary research and outreach under this framework. This article presents a logic model to evaluate how effectively the workshop met its goals.

Methodology: Two surveys were conducted, one immediately following the workshop and at the 1-year mark. These surveys assess the direct …

Inhibition Of Gpx4 Induces The Death Of P53-Mutant Triple-Negative Breast Cancer Cells, William M Tahaney, Amanda Lanier, Jing Qian, Cassandra L Moyer, Nghi Nguyen, Yanxia Ma, Jamal Hill, Reid T Powell, Clifford C Stephan, Peter J A Davies, Abhijit Mazumdar, Powel H Brown

Faculty, Staff and Student Publications

Background: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by high rates of tumor protein 53 (TP53) mutation and with limited targeted therapies. Despite being clinically advantageous, direct targeting of mutant TP53 has been challenging. Therefore, we hypothesized that p53-mutant TNBC cells rely upon other potentially targetable survival pathways.

Methods: In vitro and in silico screens were used to identify drugs that induced preferential death in TP53-mutant cells. The effect of the ferroptosis inducer ML-162 was tested both in vitro and in vivo and the mechanism of cell death following ML-162 treatment or GPX4 knockout was …

Peripheral Nerve Injury Reduces Macrophage Efferocytosis To Facilitate Neuropathic Pain, Vipul K Pandey, Tusar K Acharya, Kendal F Willcox, Sandeep Dembla, Ajeena Ramanujan, Anamaria R Grieco, Younus A Zuberi, Rajasekaran Mahalingam, Andrew J Shepherd, Cobi J Heijnen, Peter M Grace

Faculty, Staff and Student Publications

For reasons not fully understood, proresolving immune processes sometimes fail to engage after peripheral nerve injury (PNI), leading to enhanced neuropathic pain and inflammation. Here, we implicate reduced efferocytosis due to proteolytic cleavage of surface MER tyrosine kinase (MERTK) from macrophages at the site of PNI. After PNI, the proportion of macrophages expressing MERTK progressively decreased, while soluble (cleaved) MER increased. Using male and female knock-in mice encoding cleavage-resistant Mertk, we demonstrated that cleavage of MERTK from macrophages at the PNI site led to exaggerated pain-related behaviors. PNI-induced hyperactivity of TRPV1+ sensory neurons and damage to myelin and myelinated …

Spatial2gwas: A Database For Linking Spatial Transcriptomic Regions With Gwas Traits, Xi Hu, Aoqi Wang, Huan Yu, Pora Kim, Xiaobo Zhou

Faculty, Staff and Student Publications

Spatial heterogeneity of gene expression within tissue regions has a critical influence on biological functions, thereby affecting disease pathogenesis. However, systematic associations between spatially resolved transcriptomes and phenotypes, especially in complex diseases, remain underexplored. Here, we developed spatial2GWAS (http://www.spatial2gwas.cn), a comprehensive resource linking spatial transcriptomic (ST) regions with GWAS traits. In the database, we collected 1196 ST slices (human and mouse) from five technologies and 812 GWAS traits spanning 18 phenotype categories and identified 29 701 ST slice-GWAS trait pairs containing 47 492 significant regions. Functional analyses reveal distinct patterns of cell type composition, gene expression, GO/KEGG pathway activation, and …

An Eye For An Eye And A Smile For A Smile: Examining Aggressive And Supportive Behavioral Alignment Among Taiwanese Adolescence Who Play Video Games, Nicholas Bowman, Chrissy Cook, Chingching Chang

Media Studies - All Scholarship

The social dynamics of video games, especially those played online, are one of the primary motivators for gaming. Unfortunately, while there are numerous benefits to online gaming, there is also potentially harmful toxic and aggressive behavior. Prior research has investigated toxicity, but most studies rely on convenience samples, typically from WEIRD populations. The current study extends this scholarship with a nationally representative sample of Taiwanese adolescents who are frequent gamers, (a) quantifying their experiences with aggressive and supportive behaviors in games and (b) investigating personological-level variables that might explain reciprocating (referred to as “behavioral alignment”). Key findings were (1) aggressive …

N-Palmitoyl Glutamine Is A Candidate Mediator Of Cardiorespiratory Fitness, Jeremy M Robbins, Mark Benson, Anthony R P Verkerke, Gaurav Tiwari, Shuliang Deng, Prashant Rao, Usman A Tahir, Julian Avila-Pacheco, Xu Shi, Yuntian Guan, Foje-Geh Tendoh, Jacob L Barber, Patricia E Miller, Andrew S Perry, Michael E Hall, Alexis C Wood, Kent D Taylor, Wendy S Post, Stephen S Rich, Matthew Nayor, James G Wilson, Gregory D Lewis, Ravi V Shah, Jerome I Rotter, Scott A Summers, Laura M Raffield, Shingo Kajimura, Claude Bouchard, Clary B Clish, Mark A Sarzynski, Robert E Gerszten

Children’s Nutrition Research Center Staff Publications

Background: Cardiorespiratory fitness is an integrative measure of cardiometabolic health and predictor of survival, yet little is known about its molecular underpinnings. Small molecule metabolites and lipids are increasingly recognized as exercise-stimulated signaling molecules and candidate molecular transducers of cardiorespiratory fitness.

Methods: We performed nontargeted liquid chromatography mass spectrometry-based plasma metabolomics in 654 participants (mean age, 35 years; 55% women) from the HERITAGE Family Study (Health, Risk Factors, Exercise Training, and Genetics) who had cardiorespiratory fitness (maximal oxygen uptake [VO2max]) measured by cardiopulmonary exercise testing and underwent 20 weeks of supervised endurance training. Metabolite-VO2max relationships were assessed using linear regression …

Loss Of Twist1 Leads To Disruption Of Ciliary Length, Endocytic Vesicle Dynamics, And Cell-Cell Junctions During Neural Tube Formation, Derrick Thomas, Brittany M Hufft-Martinez, Zarna Lalwani, Vi Pham, Mary Elmeniawi, An J Tran, Jianming Xu, Irfan Saadi, Walid D Fakhouri

Faculty, Staff and Student Publications

Background: Endocytosis constitutes a fundamental cellular process governing development through coordinated regulation of plasma membrane remodeling and ciliogenesis, processes essential for cell shape changes and tissue development. Although Twist1 null embryos display complete cranial neural tube (NT) closure defects and conditional knockout in neuroectoderm disrupts cranial neural crest cell fate determination and delamination, the function of TWIST1 in NT morphogenesis remains unknown. We investigated the basis underlying neuroectodermal morphological abnormalities in TWIST1 mutant embryos, specifically the formation of ectopic lateral bending points and cellular disorganization, by examining Twist1's role in cilia formation, adherens junction integrity, and endocytic vesicle dynamics.

Results: …

The Indian Supreme Court Acts On The Stray Dog Issue: Is It A Crisis Or An Opportunity? Part 1, Andrew Rowan Dphil

WellBeing News

This article examines the Indian Supreme Court’s recent intervention in the country’s stray dog issue, triggered by public safety concerns following a fatal rabies case. It outlines the Court’s initial directive to remove street dogs, the legal and welfare challenges that followed, and the subsequent modification of the order to align with India’s Animal Birth Control Rules. The piece highlights the tension between public health, animal welfare, and governance, framing the Court’s actions as both a response to crisis and an opportunity to strengthen humane, lawful stray dog management nationwide.

Living With Beavers In America: Part 3, John Hadidian Phd

WellBeing News

Living with Beavers in America: Part 3 examines the evolving human-beaver relationship as these iconic ecosystem engineers return to contemporary landscapes. The article argues that much of the tension between people and beavers arises from how the animals are framed — whether as pests, natural resource commodities, recreational assets, or ecological partners. It explores the regulatory frameworks governing beaver management, typical conflict scenarios (such as tree loss and flooding), and emerging approaches that enable coexistence without unnecessary removal. Ultimately, the piece highlights the importance of reevaluating human desires and values alongside the measurable environmental contributions beavers make, offering insights into …

"Memory-Go-Round" And Other Poems, Chrissie Anderson Peters

Critical Humanities

No abstract provided.

"Alive" And Other Poems, Doug Van Gundy

Critical Humanities

Alive

Grief is a Three-Legged Dog

Undomesticated

Violin

Kibbutz Megiddo (Al-Lajjun): The Faunal Remains, Guy Bar-Oz, Laila Abado

Qadum: Journal of Excavation Reports from Israel

This report discusses a small bone assemblage retrieved from the Hellenistic–Mamluk strata at Kibbutz Megiddo (al-Lajjun). The assemblage is predominantly composed of livestock taxa, including sheep, goats, cattle and chickens. Notably, camel bones are present in almost all strata, with the exception of the Hellenistic period stratum. Pathological analysis of cattle foot bones suggests that these animals were also used as beasts of burden.

Excavations At Beit Safafa: Iron Age Ii And Byzantine Agricultural Installations South Of Jerusalem, Nurit Feig

'Atiqot

No abstract provided.

Excavations At Tel Gat-Ḥefer In The Lower Galilee, Areas A And B, Yardenna Alexandre, Karen Covello-Paran, Zvi Gal

'Atiqot

No abstract provided.

The Early Bronze Age Occupation At Tel Gat-Ḥefer, Lower Galilee, Areas C And D, Karen Covello-Paran

'Atiqot

No abstract provided.

An Early Bronze Age Ib Burial Cave And A Byzantine Farm At Ḥorbat Ḥani (Khirbet Burj El-Ḥaniya) (West), Egon H.E. Lass

'Atiqot

No abstract provided.

The Stripes Of Glory We Wear: Reflections Of The Legal Role And Intricacies Of Citizenship In The History And Foundation Of The Malaysian State

Washington International Law Journal

Abstract: The meaning of citizenship in Malaysia is a tale as old as the country itself—a thorny triangular relationship between the state; the Bumiputera majority of Malay and indigenous natives; and the non-Bumiputeras minority of Chinese and Indians who primarily migrated when the region was under British colonial rule and influence. In the present, Bumiputeras enjoy a constitutionally stipulated special status—a distinction that bestows many privileges and preferential treatment in all facets of life, from commerce to education, homeownership to government employment, that is off-limits to non-Bumiputeras. Supporters of the system argue it remains necessary—a form of affirmative action …

Faculty Senate Agenda January 5, 2026, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• 3:00 Call To Order
• Approval of Minutes December 1, 2025
• Approval of Amended Minutes November 3, 2025
• 3:05 University Business
• 3:20 Faculty Senate Business
• 3:35 Reports
• Council on Teacher Education
• Scholarship Annual Report
• University Studies Report
• 3:50 Old Business
• 3:55 New Business
• Commencement
• 4:00 Information
• EPC Report - December 4, 2025
• Adjourn: 4:30 pm

Towards A Unified Gating Scheme For The Cnbd Ion Channel Family, Jenna L Lin, Baron Chanda

2020-Current year OA Pubs

Cyclic nucleotide-binding domain (CNBD) channels are critical components of numerous bioelectrical processes, including cardiac pacemaking, neuronal signaling, phototransduction in the eye, and stomatal regulation in plants. While members of this channel family share a conserved overall structure, they exhibit striking differences in voltage sensitivity. Hyperpolarization-activated cyclic nucleotide-gated channels are activated by membrane hyperpolarization, whereas ether-à-go-go channels open upon depolarization. Mutagenesis and chimeragenesis studies have revealed that some mutants display bipolar gating behavior-remaining closed at intermediate membrane potentials but capable of opening in response to both hyperpolarization and depolarization. Remarkably, in certain cases, just a few mutations are sufficient to reverse …

Reviewing Crowdsourcing And Community Engagement In Museums, Paul Longley Arthur, Lydia Hearn, Isabel Smith

Research outputs 2022 to 2026

Over the past two decades, museums have increasingly experimented with digital technologies to connect with broader contemporary culture. This review article investigates the role crowdsourcing can play in transforming museums into more engaged environments, raising visibility and inclusivity, and involving diverse voices and populations in knowledge-creation processes. Its contribution is to provide an overview of the history, definitions and concepts of crowdsourcing, and examples of crowdsourcing policies and practices that have been adopted by museums. Participation in crowdsourcing has been influenced by gender, education, and socio-economic and cultural background. In the past, historical structures and traditions and infrastructural complexities have …

Safety And Tolerability Of Single And Multiple Daily Oral Doses Of Dried Kratom Leaf Powder In A Randomized Trial In Healthy Volunteers, Marilyn A. Huestis, John Bothmer, Thomas Hudzik, Jack E. Henningfield, Sibyl Swift

Institute of Emerging Health Professions Faculty Papers

BACKGROUND: Kratom use is rising, increasing the need for safety and tolerability studies of high-quality and well-characterized kratom products in humans. Kratom's risk-benefit ratio, recommended dose, treatment-emergent adverse events (TEAEs), abuse potential, and withdrawal require evaluation. Thus, the safety and tolerability of 4 escalating single and 15 daily dried kratom leaf powder doses in human volunteers were evaluated over 47 days in the largest controlled kratom-administration study to date.

METHODS: A randomized, between-subject, double-blind, placebo-controlled, dose-escalation study of MitraLeaf kratom powder after single doses (SD), during 15 daily doses (multiple doses; MD), and a 23-day follow-up was conducted in 116 …

Β2 And Β3a Regulatory Subunits Can Coassemble In The Same Bk Channels, Yu Zhou, Vivian Gonzalez-Perez, Xiao-Ming Xia, Gopal S Kallure, Sandipan Chowdhury, Christopher J Lingle

2020-Current year OA Pubs

Ca2+- and voltage-activated BK-type K+ channels are influenced profoundly by associated regulatory subunits, including β subunits (Kcnmb1-4; β1-β4). Although overlap in expression of different BK β subunits occurs in native tissues, whether they can coassemble in the same channel complex is not known. We coexpress β2 and β3a subunits together with BK α and, through a combination of macroscopic and single-channel recordings, along with quantitative pull-down of tagged subunits, test whether coassembly can occur. We evaluate two models: (1) random mixing in which β2 and β3a subunits coassemble in the same channels, and (2) segregation in which β2 and β3a …

Tampa Bay Mycobiome, Alyssa L. Fischer, Yanori M. Ferguson, Ojas Natarajan, Larry J. Dishaw

Making Waves REU

The marine mycobiome is a largely unexplored area of research despite its importance to the environment as a carbon sink, nutrient manager, and as a symbiont of various marine life. With rising temperatures, there is a need to identify the fungi present in these environments to monitor changes in biodiversity and their effect on climate change. Along Tampa Bay, six sites were chosen to collect samples from surface water using a CTD rosette system. The collected water was filtered, and DNA was extracted in order to classify and catalog species of both bacteria and fungi through 16S and ITS sequencing, …

Multi-Omics Comparison Of Two Emerging Storage Pests (Necrobia Rufipes And Tribolium Castaneum) Of Dried Black Soldier Fly Larvae Product, Inusa Jacob Ajene, Chrysantus M. Tanga, Komivi S. Akutse, Samantha W. Karanu, Fathiya M. Khamis

All Peer-Reviewed Publications

The black soldier fly (BSF) larvae is a rich and promising source of alternative protein that continues to increasingly gain global traction as a functional ingredient for sustainable livestock and fish production. The key setback to postharvest processing of stored BSF larvae (BSFL) products is the significant damage caused by two notable storage pests (Tribolium castaneum and Necrobia rufipes). Here, we present a comparative analysis of the complete mitochondrial genomes and gut microbiome profiles of T. castaneum and N. rufipes. The study mitogenomes were similar in size and structure to other coleopteran mitogenomes. The gut microbiome profiles of the two …

The West And The Rest: Misplaced Blame Of Underdevelopment, Rana R. Abadeer

Theses and Dissertations

This paper will discuss the link between the history of colonialism and the genesis and evolution of International Law and in turn the role played by this relationship to maintain it, directly or indirectly, to our current day. The blame of underdevelopment is often misplaced, and its responsibility falls on the Global South for their inability to follow the same momentum of development as the Global North. Nevertheless, the aim of this paper is to prove that this blame of underdevelopment given its original reasons should be placed elsewhere. With that, the discussion of where the blame should be is …

A Systematic Literature Review Of Cvid Reveals Pervasive Detrimental Noninfectious Manifestations, G Michelle Ducasa, Rebecca A Marsh, Ali Mojebi, Hsi-En Ho, Charlotte Cunningham-Rundles, Lisa Forbes Satter, Elena W Y Hsieh, Sinisa Savic, Marta Dafne Cabañero-Navalón, Hector Balastegui-Martin, Joud Hajjar, Gulbu Uzel, Kevin S Thorneloe, Jocelyn R Farmer

Faculty, Staff and Students Publications

Noninfectious manifestations of common variable immunodeficiency (CVID) are not formally summarized. We performed a systematic literature review to generate a comprehensive reference for the field. Splenomegaly was the most reported manifestation across 53 publications, occurring in a median of 35.2% of patients. Frequently reported digestive system manifestations included diarrhea (median 27.8%; 21 publications), hepato(spleno)megaly (median, 21.0%; 19 publications), portal hypertension (median 21.0%; 3 publications), nodular lymphoid hyperplasia (median, 17.0%; 9 publications), and enteropathy (median, 16.0%; 34 publications). Other notable manifestations included interstitial lung disease (median, 8.7%; 32 publications) and autoimmune cytopenias (median 18.0%; 21 publications). Steroids and rituximab were the …

Pathogenesis Of Polyglutamine Diseases: Piecing Together A Complex Molecular Puzzle, Esmeralda Villavicencio Gonzalez, Huda Y Zoghbi

Duncan NRI Faculty and Staff Publications

Polyglutamine (polyQ) diseases, caused by a CAG repeat expansion encoding a glutamine tract in nine distinct proteins, present a complex molecular puzzle in which each piece contributes to neurodegeneration. While each of the causative proteins has a distinct function, the downstream consequences of polyQ toxicity are often similar, including protein accumulation, transcriptional dysregulation, somatic CAG repeat instability, disrupted energy homeostasis, compromised synaptic function, and selective neuronal death. This review summarizes emerging insights into how proteins with an expanded polyQ tract disrupt distinct cellular functions, and we examine a multitude of discoveries that are inspiring and reshaping novel therapeutic strategies.

Scriptor Latinus Morigeris -- Some Aspects Of Gower’S Latin Usage, Mark T. Riley

Accessus

This paper describes the distinctive characteristics of John Gower’s Latin as illustrated primarily by his Vox Clamantis, although his shorter Latin works are occasionally mentioned. Topics include Gower’s Latin education, his extensive Latin vocabulary and mythological references, the paragraphing of his poem, his procedures for using or adapting quotations, as well as his characteristic wordplay and punning. Further topics cover Gower’s medieval use of various verbs, pronouns, and conjunctions, with the accompanying grammatical structures, some of which may present difficulties for the translator. Also included is a section on the meter of the Vox Clamantis, with some notes on …