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Impaired Β-Cell Neogenesis In A Mouse Model Of Metabolic Syndrome, Modhi Abdullah Alshammari

Browse all Theses and Dissertations

Pancreatic islet β-cell plays an essential role in insulin release and hence glucose homeostasis. The maintenance of glucose homeostasis depends on β-cell ability to cope with enough insulin to fulfill metabolic and physiological demands. Adequate insulin release is the result of highly complex and dynamic interplays between acute changes in β- cell electrical activity, exocytosis and chronic adaptations in cellular function, volume, mass and proliferation. All of this appears modulated, to some extent, by the functional presence of Slc12a2 symporters, also known as Na+K+2Cl– cotransporter-1 (Nkcc1), which accumulates intracellular Cl– above its electrochemical equilibrium. Recent studies from our laboratory showed …

Evaluating Energy-Based Trait Shifts And Population Level Impacts Of Big Brown Bats (Eptesicus Fuscus) With Long-Term Exposure To Pseudogymnoascus Destructans, Molly C. Simonis

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Disturbances in environment can lead to a wide range of host physiological responses. These responses can either allow hosts to adjust to new conditions in their environment or can reduce their survival, and can subsequently cause host traits to shift. Small mammals are particularly vulnerable to stochastic disturbances, like a pathogen introduction, because of their high energy demands. Studies examining host responses to pathogens often focus on species highly susceptible to infection that typically have high mortality rates, leading to a gap in understanding the responses of less susceptible species. My dissertation evaluates the energy balance of Eptesicus fuscus (big …

Evaluation Of A Monosynaptic Spinal Circuit In Multiple Mouse Models Of Amyotrophic Lateral Sclerosis, Maura A. Curran

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Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. To date, there are no significant disease-modifying treatments, and one limiting factor in treatment is the amount of time it takes for a patient to receive a diagnosis of ALS. This study examined multiple mouse models before symptom onset to help identify early changes in a reflex circuit of ALS mice. Dorsal root stimulation of the sacral spinal cord in multiple models ALS mouse models showed changes in the resulting ventral root compound action potential amplitude, latency, and ability to maintain synaptic depression. These data also suggest that a mouse model …

Community-Level Effects Of A Widescale Reduction In White-Tailed Deer (Odocoileus Virginianus) Density, Mariah Slaughter

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The prolonged overabundance of white-tailed deer (Odocoileus virginianus) throughout the deciduous forests of eastern North America has resulted in widespread changes in the understory community. Studies have demonstrated that the exclusion of deer can allow some aspects of the understory to recover, but there are strong time-lags for deer-preferred species. Additionally, these exclosures only test the presence/absence of deer, which is not a feasible management option or desirable as deer are a part of the community. Here I evaluate how large-scale deer density manipulations within the Kinzua Quality Deer Cooperative of Pennsylvania affected understory vegetation communities. Using data from six …

Use Of Forelimb Asymmetry In The Analysis Of Cns Recovery From A Demyelination Event, Joseph C. Hinkle

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Using forelimb asymmetry analysis along with Montoya Staircase methodology we tested how a fluoxetine simvastatin ascorbic acid drug cocktail would affect recovery from a demyelinating event in a rat model, with the hypothesis that if administered then it would help female recovery but hinder male recovery. It was found that a fluoxetine simvastatin and ascorbic acid drug cocktail did not significantly enhance recovery from a demyelination model injury in female rats, and that the same drug cocktail significantly slowed male rat recovery from the same type of injury. It was also apparent that the more effective methodology for investigating this …

Interview With [Anonymous] [2], Ezra Schrader

Interviews

Transcript of interview and audio recording conducted with [Anonymous]. Per the "Methodology" section, the transcript has been lightly edited for clarity. The interview begins at 00:16:43 in the audio recording.

This interview was recorded over Zoom and manually transcribed.

A History Of Freed Slaves' Homes In Northern Nigeria, 1900-1926, Ajibola A. Abdulrahman

Electronic Theses and Dissertations

This dissertation is about the children rescued from slave traders by the British colonial government in Northern Nigeria in the early twentieth century. The children were first settled in state-owned Freed Slaves Homes located at Zungeru and Borno provinces in 1904. After the state-owned Homes were abolished in 1909, they were moved to the privately-owned Lucy Memorial Freed Slaves’ Home. The study focuses on the experiences of these liberated children within the premises of the Freed Slaves' Homes and in settings outside of these institutions in Northern Nigeria. Drawing on previously unused archival materials obtained from various parts of the …

The Perception And Strategies Of Speech-Language Pathologists In Rapport Building With People With Aphasia Via Tele-Practice: Qualitative And Quantitative Mixed Design, Emily Hershberger

Electronic Theses and Dissertations

Introduction: Tele-practice has become an important service delivery method, especially since the Covid-19 pandemic. A majority of research investigated effectiveness in therapeutic outcomes among children and adolescents, while tele-practice studies among people with aphasia were relatively limited. Rapport building may present more challenges in tele-practice compared to in-person services, yet no study compared it across the two therapy delivery approaches among people with aphasia.

Method: This current study conducted interviews regarding how rapport building is affected in tele-practice from speech-language pathologists (SLPs) who have experienced both in-person and tele-practice among people with aphasia. Nine SLPs were interviewed about their perceptions …

The Resilience Of Black Love, Janeth Jackson

Electronic Theses and Dissertations

For countless years, a network of laws, codes, systemic structures, and malicious forces have been established to eradicate Black love. Despite such evils, African Americans have been steadfast in their love for one another. In the American South, the evidence of that steadfastness is the strongest. States like Mississippi, Georgia, and Louisiana all had racist systems such as slavery, Jim Crow, Black Codes, and lynching that African Americans faced daily. And within each structure, there were methods employed to separate Black couples. Some historical texts have examined the plight of African American couples’ fight against such systems. However, few studies …

Copyright: A Contemporary Approach, Robert Brauneis, Roger Schechter

GW Law Faculty Publications & Other Works

This Fall 2022 Supplement is the product of our effort to capture important developments in copyright law since the publication of the second edition of Copyright: A Contemporary Approach. It includes three new principal cases. The first two are Supreme Court decisions: the 2021 fair use decision in Google LLC v. Oracle America, Inc. (p. 18), and the 2020 decision about copyright protection for state statutes in Georgia v. Public.Resources.Org (p. 58).. The third is an excerpt from the Second Circuit’s fair use decision in Andy Warhol Foundation v. Goldsmith (p.37), a decision that the Supreme Court has decided to …

Biology 102 Lab Manual, Jeffrey Ray, Jason Jones

Textbooks

No abstract provided.

Perinatal Substance Use Disorders And Co-Occurring Posttraumatic Stress Disorder, Kaitlyn Dickens

DSW Capstone Projects

Pregnant and postpartum or perinatal women who experience Substance Use Disorder and Posttraumatic Stress Disorder (SUD/PTSD) co-occurring are an underserved population and a gap can be observed in the research in terms of clinical presentation and treatment of SUD/PTSD among this population. Social work practitioners are at an increased probability of working with individuals who would identify as such. There are many psychosocial and health factors associated with untreated SUD/PTSD among perinatal women for both mother and baby.

Research suggests that the use of client centered approaches and narrative therapy is beneficial in working with those who experience PTSD. The …

Clinical Interventions For Developmental Trauma Disorder: How Evidence-Based Practice And Attachment Theory Can Inform Therapeutic Approach, Victoria Deveau

DSW Capstone Projects

Approximately two-thirds of U.S. children and adolescents report having experienced a traumatic event. A posttraumatic stress disorder (PTSD) diagnosis requires that the youth has directly experienced a traumatic event, witnessed a traumatic event occur to others, or learned that a traumatic event has occurred to someone close. The clinician is in a diagnostic quandary, however, when the youth presents with the PTSD hallmarks of hyperarousal, avoidance, and emotional dysregulation, in absence of such life experiences. The answer to this quandary lies in an understanding of developmental trauma disorder (DTD). Clinical interventions for DTD are the focus of this capstone.

Product …

Trust In Human-Robot Interaction Within Healthcare Services: A Review Study, Dedra Townsend, Amirhossein Majidirad

Mechanical & Aerospace Engineering Faculty Publications

There has always been a dilemma of the extent to which human can rely on machines in different activities of daily living. Ranging from riding on a self-driving car to having an iRobot vacuum clean the living room. However, when it comes to healthcare settings where robots are intended to work next to human, making decision gets difficult because repercussions may jeopardize people’s life. That has led scientists and engineers to take one step back and think out of the box. Having concept of trust under scrutiny, this study helps deciphering complex human-robot interaction (HRI) attributes. Screening essential constituents of …

The Effects Of Mand-Model Within Shared Reading Activity On Naming Emotions, Paige Nicole Owens

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

There is a need for social communication skills to be explicitly taught to people with intellectual disabilities and complex communication needs. The use of naturalistic language interventions is an evidenced based practice shown to increase social communication skills in learners with disabilities. In addition, these interventions have proven successful when embedded into a storybook reading format. There is limited evidence when using both strategies to teach the skill of naming emotions. The purpose of this study was to determine the effectiveness of a mand-modeling procedure, during storybook reading, to teach middle schoolers with moderate and severe disabilities to name emotions …

Teaching Children To Use Interaction Strategies With Their Younger Siblings That Are Minimally Verbal, Abby Rucker

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

Children that are minimally verbal often lack same- or near-age peer interaction outside of the home environment. This study attempted to bridge that gap by training older siblings of minimally verbal children to use interaction strategies during play sessions. Through this, researchers were able to examine both the fidelity of use of the trained interaction strategies as well as their effect of the younger siblings’ communication skills.

Coaching And Training Paraprofessionals To Implement Communication Strategies In The Classroom With Students With Disabilities, Andrea Grace Antoniewicz

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

The purpose of this project was to evaluate the effects of a training and coaching intervention on increasing paraprofessionals use of communication strategies to increase the participation between students with disabilities and paraprofessionals. Students with CCN struggle to interact with peers and communicate appropriately, and therefore need guided instruction by adults. To encourage interactions across contexts, paraprofessionals must first learn how to use communication strategies. This skill also was chosen to extend our knowledge on coaching paraprofessionals to use different communication strategies to promote communication with students with ESN and CCN.

Fracture Resistance Of Root Canal-Treated Molars Restored With Ceramic Overlays With/Without Different Resin Composite Base Materials: An In Vitro Study, Hend Sayed Ahmed, Mohamed Fouad Haridy, Shehabeldin Saber, Mohamed Kataia, Edger Schafer

Dentistry

No abstract provided.

The Anti-Human Rights Machine: Digital Authoritarianism And The Global Assault On Human Rights, Richard Ashby Wilson

Faculty Articles and Papers

Across the world, governments and state-aligned actors increasingly target human rights defenders online using techniques such as surveillance, censorship, harassment, and incitement, which together have been termed “digital authoritarianism.” We currently know little about the concrete effects on human rights defenders of digital authoritarianism as researchers have focused primarily on hate speech targeting religious, national, and ethnic minority groups. This article analyzes the effects of digital authoritarianism in two countries with among the highest rates of killings of human rights defenders in the world; Colombia and Guatemala. Anti-human rights speech in these countries portrays defenders as Marxist terrorists who are …

Under A Nifty Light: Trademark Considerations For The New Digital World, Willajeane Mclean

Faculty Articles and Papers

No abstract provided.

The Next Pandemic Might Be A Petdemic, Hillary Greene

Faculty Articles and Papers

A new scientific study shows that COVID-19 can be transmittedf rom cats to humans. Luckily, this channel of transmission seems extremely rare, at least thus far. But next time and there will be a next time we may not be so fortunate. This Article addresses this underappreciated risk of what I term a "petdemic" a pandemic or epidemic that involves significant disease transmission between pets and humans. With nearly 70% of U.S. households owning pets, a petdemic could be catastrophic. One of our go-to responses for even perceived petdemics, honed over the last century, is to slaughter our pets. This …

The New Privity In Personal Jurisdiction, Alexandra Lahav

Faculty Articles and Papers

Personal jurisdiction doctrine should be understood largely in relation to the substantive law. The doctrine makes sense when it is in harmony with state substantive law. It fails to cohere to the extent that it diverges from state substantive law. In the case of products liabilhiy law, which was at issue in the most recent personal jurisdiction case to come before the Court, personal jurisdiction doctrine attempts to balance the social obigation to produce safe products with immunity from suit. Until recently, the Roberts Court had failed to harmonize personal jurisdiction with substantive state law; indeed, it had usurped state …

Kinorhynch Diversity In The Southern Gulf Of Mexico And A Description Of Dracoderes Chaac Sp. Nov., Stephen C. Landers, Kellan Hoffman, Nuria Sanchez, Martin Sorensen

Gulf and Caribbean Research

Sediment collections from the southern Gulf of Mexico between the Texas—Mexico border and the Yucatán Peninsula have resulted in many new kinorhynch species distribution records and the finding and taxonomic description of a new species, Dracoderes chaac sp. nov. This study focused on the non—echinoderid members of the Phylum Kinorhyncha, many of which are rare or restricted to only a few locations. A total of 136 specimens were identified from 24 sediment stations, distributed among the following species: Antygomonas gwenae, Campyloderes vanhoeffeni, Centroderes readae, Condyloderes flosfimbriatus, Co. rohalorum, Cristaphyes panamensis, Dracoderes chaac sp. nov., …

Strengthening Marine Species Protections In Cuba: A Case Study On The Critically Endangered Smalltooth Sawfish, Olga Koubrak, Fabián Pina Amargós, José Alberto Álvarez Lemus, Tonya Wiley, Katie Thompson, Tamara Figueredo Martín, Fernando Bretos, Sonja Fordham

Gulf and Caribbean Research

The Smalltooth Sawfish (Pristis pectinate), a critically endangered species of ray, is in urgent need of strong legal protection and conservation action in the Wider Caribbean Region, particularly in Cuba. Cuba has a long history of conservation initiatives for other marine species and is a signatory to multiple multinational agreements that direct the country to protect sawfish. Nevertheless, sawfish are only just beginning to be a species of concern on the island. Here we review existing domestic laws relevant to biodiversity and endangered species protection in Cuba, with a focus on safeguarding sawfish. We offer specific recommendations to …

Life History Of Swordfish, Xiphias Gladius, Caught In The Northern Gulf Of Mexico, Anna K. Millender, Jeremy M. Higgs, Nancy J. Brown-Peterson, Michael J. Andres, James S. Franks

Gulf and Caribbean Research

The current study examined 93 Swordfish, Xiphias gladius, (64 females, 27 males, 2 unknown) ranging in size from 77.6–246.3 cm lower jaw fork length (LJFL) from the northern Gulf of Mexico (GOM). Samples were collected between March and August in 2005–2007, 2017–2019 and 2021. Age estimates of 51 Swordfish resulted in a maximum observed age of 11 years (205.0 cm LJFL) and 7 years (190.4 cm LJFL) for females and males, respectively. Observed and back—calculated length—at—age data were fitted to 4 growth models (2— and 3— parameter von Bertalanffy, Gompertz, and logistic). The 2—parameter von Bertalanffy was the model …

Genomic Degeneration And Reduction In The Fish Pathogen Mycobacterium Shottsi, David T. Gauthier, Janis H. Doss, M. Lagatta, T. Gupta, R.K. Karls, F. D. Quinn

Biological Sciences Faculty Publications

Mycobacterium shottsii is a dysgonic, nonpigmented mycobacterium originally isolated from diseased striped bass (Morone saxatilis) in the Chesapeake Bay, USA. Genomic analysis reveals that M. shottsii is a Mycobacterium ulcerans/Mycobacterium marinum clade (MuMC) member, but unlike the superficially similar M. pseudoshottsii, also isolated from striped bass, it is not an M. ulcerans ecovar, instead belonging to a transitional group of strains basal to proposed “Aronson” and “M” lineages. Although phylogenetically distinct from the human pathogen M. ulcerans, the M. shottsii genome shows parallel but nonhomologous genomic degeneration, including massive accumulation of pseudogenes accompanied by proliferation of …

Rickettsial Pathogen Perturbs Tick Circadian Gene To Infect The Vertebrate Host, Supreet Khanal, Vikas Taank, John F. Anderson, Hameeda Sultana, Girish Neelakanta

Biological Sciences Faculty Publications

Ixodes scapularis is a medically important tick that transmits several microbes to humans, including rickettsial pathogen Anaplasma phagocytophilum. In nature, these ticks encounter several abiotic factors including changes in temperature, humidity, and light. Many organisms use endogenously generated circadian pathways to encounter abiotic factors. In this study, we provide evidence for the first time to show that A. phagocytophilum modulates the arthropod circadian gene for its transmission to the vertebrate host. We noted a circadian oscillation in the expression of arthropod clock, bmal1, period and timeless genes when ticks or tick cells were exposed to alternate 12 h …

Editorial: Tick Saliva: Secret To Blood Feeding Success, Daniel E. Sonenshine, Patricia A. Nuttall, Sukanya Narasimhan

Biological Sciences Faculty Publications

No abstract provided.

Compassion, Discrimination, And Prosocial Behaviors: Young Diasporic Chinese During The Covid-19 Pandemic, Youli Chen, Zicong Wang, Qi Zhang, Weizhen Dong, Jia Huei, Chen Xu, Sizhe Ji Wu, Xiangyang Zhang, Chun Chen

Community & Environmental Health Faculty Publications

The coronavirus disease 2019 (COVID-19) pandemic has fueled anti-Asian, especially anti-Chinese sentiments worldwide, which may negatively impact diasporic Chinese youths' adjustment and prosocial development. This study examined the association between compassion, discrimination and prosocial behaviors in diasporic Chinese youths during the COVID-19 pandemic. 360 participants participated and completed the multi-country, cross-sectional, web-based survey between April 22 and May 9, 2020, the escalating stage of the pandemic. This study found compassion as prosocial behaviors' proximal predictor, while discrimination independently predicted participation in volunteering, and could potentially enhance the association between compassion and charitable giving. These findings suggest that prosociality among young …

Toxic Effects Of Silver Ions On Early Developing Zebrafish Embryos Distinguished From Silver Nanoparticles, Martha S. Johnson, Preeyaporn Songkiatisak, Pavan Kumar Cherukuri, Xiao-Hong Nancy Xu

Chemistry & Biochemistry Faculty Publications

Currently, effects of nanomaterials and their ions, such as silver nanoparticles (Ag NPs) and silver ions (Ag⁺), on living organisms are not yet fully understood. One of the vital questions is whether nanomaterials have distinctive effects on living organisms from any other conventional chemicals (e.g., their ions), owing to their unique physicochemical properties. Due to various experimental protocols, studies of this crucial question have been inconclusive, which hinders rational design of effective regulatory guidelines for safely handling NPs. In this study, we chronically exposed early developing zebrafish embryos (cleavage-stage, 2 hours post-fertilization, hpf) to a dilution series of …