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Tissue And Sex-Specific Rna Editing During Induced Acute Inflammation, Claire E. Nichols Jan 2022

Tissue And Sex-Specific Rna Editing During Induced Acute Inflammation, Claire E. Nichols

Graduate Theses/Dissertations

A-to-I RNA editing is a process where select adenosine (A) nucleotides are deaminated by an editing enzyme, ADAR, to become inosines (I) in RNA transcripts. RNA editing can affect the sequence of the encoded protein and the regulation of the RNA. ADAR1 also plays a role in regulating innate immunity and its expression is upregulated during inflammation. Current data on the effects of increasing ADAR1 on RNA editing is limited, and most studies are completed only in male animals. We are interested in expanding RNA editing data to include female animals. Lipopolysaccharide (LPS) was used to induce acute inflammation and …

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Maintenance Of Language And Learning Skills Using Peak Relational Training During Extended School Closure, Kayla Marie Welch Jan 2022

Maintenance Of Language And Learning Skills Using Peak Relational Training During Extended School Closure, Kayla Marie Welch

Graduate Theses/Dissertations

Autism Spectrum Disorder (ASD) is a developmental and neurological disorder that affects how people communicate, interact with others, behave, and learn. Applied Behavior Analysis is a scientific approach to predicting and influencing behavior that has been applied successfully in supporting children with ASD. Due to communication and intellectual differences experienced by those diagnosed with ASD, it is important to identify therapies and interventions that focus on language development as well as maintenance of intervention gains during unexpected lapses in instruction. The PEAK Relational Training System (Dixon et al., 2017)is a treatment framework that exists within ABA to address language and …

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Elucidating The Role Of Hemodynamic Force In Regulating The Attachment Of Vascular Smooth Muscle Cells (Vsmcs) To Maturing Vessels During Mouse Embryonic Development, Israt Jahan Jan 2022

Elucidating The Role Of Hemodynamic Force In Regulating The Attachment Of Vascular Smooth Muscle Cells (Vsmcs) To Maturing Vessels During Mouse Embryonic Development, Israt Jahan

Graduate Theses/Dissertations

Blood vessel maturation is characterized by the recruitment and attachment of vascular smooth muscle cells (vSMCs) around immature blood vessels, which ultimately form the tunica media. Improper maturation can lead to vascular birth defects ranging from minor birthmarks to lethal brain aneurysms. Previously, our lab demonstrated that hemodynamic force plays an important role to regulate vSMCs recruitment from neighboring low-flow to high-flow vessels followed by the attachment of these vSMCs to the high-flow vessels. To understand the reason for the preferred attachment of vSMCs to high-flow vessels, instead of low-flow vessels, I hypothesize that hemodynamic force modulates the expression of …

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Crutches, James Preston Heil Jan 2022

Crutches, James Preston Heil

Graduate Theses/Dissertations

The following thesis is a collection of creative nonfiction essays, poems, and short stories. The overarching theme of this body of work is Millennial-aged adults grappling with a variety of traumas both personal and global; this dovetailing of personal grief alongside international grief is meant as an artistic expression of anxiety. In other words, the question posed here is: what does a young adult make of a world that is incessantly brutal? The answer is explored in both fictional and nonfictional ways, and no definitive conclusion is given. Rather, the events of the stories contained herein are representative of the …

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Development Of Peg-B-Pla Based Micelles For Neutralization Of A Toxic Peptide, Giselle Campos Jan 2022

Development Of Peg-B-Pla Based Micelles For Neutralization Of A Toxic Peptide, Giselle Campos

Graduate Theses/Dissertations

I herein report the preparation and characterization of PEG-b-PLA block copolymer micelles and PEG-b-PLA/PLA mixed micelles as potential “plastic antidotes” for a toxic peptide, melittin. PEG-b-PLA micelles have been used in a number of biomedical applications for their biodegradability and biocompatibility. Along these lines, I investigated the colloidal stability and the peptide absorption properties of PEG-b-PLA/PLA mixed micelles. A series of PEG-b-PLA block copolymer micelles and PEG-b-PLA/PLA mixed micelles were prepared, and their colloidal stability was studied. The hydrodynamic diameters of stable micelles were determined by using Dynamic …

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Effects Of Sex And Reproductive Condition On Behavior Of Southern Red-Backed Salamanders: Activity, Agonistic Behavior And Escape Velocity, Megan N. Mosier Jan 2022

Effects Of Sex And Reproductive Condition On Behavior Of Southern Red-Backed Salamanders: Activity, Agonistic Behavior And Escape Velocity, Megan N. Mosier

Graduate Theses/Dissertations

Producing and carrying eggs is energetically costly and therefore can affect behavior. Female Southern Red-backed Salamanders (Plethodon serratus) in the Ozarks reproduce biennially, and so during the reproductive season some females are gravid and some are non-gravid. In this study, we compared the exploratory and aggressive behaviors of gravid females, non-gravid females, and males, as well as the escape velocities of each sex class. In exploratory trials, sex did not affect distance travelled, but gravid females and males showed shorter latencies to move than non-gravid females during the winter. During the aggression trials, individuals were subjected to a …

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It’S Still Hot In Here: Exploring The Relationship Between Incentivization And Climate Related Behaviors To Combat Climate Change, Meredith T. Matthews Jan 2022

It’S Still Hot In Here: Exploring The Relationship Between Incentivization And Climate Related Behaviors To Combat Climate Change, Meredith T. Matthews

Graduate Theses/Dissertations

Consumer behavior continues to play a centralized role in the anthropogenic (i.e., human) factors causing exponentiated rates of climate change at a global scale. The present study utilized a mixed-method research design which combined components from both quantitative and qualitative research. The purpose of the mixed-methods study was to examine the extent to which self-monitoring and incentivization through extra credit in a graduate psychology course would impact participants pro or anti-climate behaviors using two commercially available applications. In the primary study, eight participants selected from a graduate psychology course at Missouri State University completed a combined intervention including self-monitoring of …

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Ouroboros, Haley R. Biere Jan 2022

Ouroboros, Haley R. Biere

Graduate Theses/Dissertations

My work uses both painterly and sculptural elements to convey my personal transgender experience. My work is for the little girl who I was, who was incapable of speaking out or expressing themselves. I create work for others that face similar situations, as well as for those who face feelings of gender dysphoria, as I did and still do by not conforming to the gender I was assigned. Working the way that I do is a way for me to rediscover myself after years of shoving my identity to the side for the sake of others. Growing up in rural …

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Effectiveness Of Stabilized Hypochlorous Acid In Acute Peritonitis Treatment: A Murine Surgical Study, Benjamin Michael Pomeroy Jan 2022

Effectiveness Of Stabilized Hypochlorous Acid In Acute Peritonitis Treatment: A Murine Surgical Study, Benjamin Michael Pomeroy

Graduate Theses/Dissertations

Peritonitis is an inflammatory condition affecting the mesothelial cells that line the peritoneal cavity and is commonly induced by bowel perforations. This medical emergency is treated through antibiotic therapy and surgical intervention followed by tissue irrigation (lavage). Acute treatments aim to remove the bacterial burden, however recurring peritoneal infections occur at high rates and contribute to patient morbidity. These recurring infections are likely due to the inability of lavage solutions to remove the entire massive intra-abdominal bacterial load due to intestinal perforation. Numerous antiseptic solutions and antibiotic additives have been evaluated in their ability to improve source control by abdominal …

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Intercropping Grain Sorghum Into Established Rhizoma Peanut: Greenhouse And Field Studies, Erika Hm Cooperman Jan 2022

Intercropping Grain Sorghum Into Established Rhizoma Peanut: Greenhouse And Field Studies, Erika Hm Cooperman

Graduate Theses/Dissertations

Land degradation and urbanization are among the top factors pushing the Kenyan Maasai community into an unstable future, with food insecurity and poverty amidst the most fragile components. Implementing conservation agricultural techniques into the Maasai nomadic lifestyle could potentially lead to a diversification of finances and food security. Intercropping is one technique of conservation agriculture that could provide the Maasai both. The main objective of this study is to evaluate the effects of creating an intercropped environment between rhizoma peanut and grain sorghum. A greenhouse study was conducted from late 2020 to 2021 in an effort to investigate the effects …

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Splitleaf, Sean M. Turlington Jan 2022

Splitleaf, Sean M. Turlington

Graduate Theses/Dissertations

Set in the fantasy world of Vriim, Splitleaf follows the story of the protagonist Dellum Lovira as he journeys to regain his freedom, find purpose in his life once he has freedom, and develop into a self-actualized person beyond the shadow of his mother and the societal judgement for his multiracial status. Raised on the island chain of Riitol, Dellum is a half-blood between a human father and a Nifaren mother, a race of scaled and feathered people whose emotional investment struggles to move beyond self-interest. He must in the early chapters included here travel back to his original home, …

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The Me [Unnamed]: Essays, Rebecca Ann Harris Jan 2022

The Me [Unnamed]: Essays, Rebecca Ann Harris

Graduate Theses/Dissertations

This creative thesis includes six flash nonfiction pieces and four essays exploring my relationships with my father, mother, and older sister; this exploration is filtered through the lenses of trauma and mental illness. Notably, five of the six flash nonfiction pieces are written in the literary mode of magical realism, which are analyzed in this thesis’ critical introduction. By evaluating magical realism’s origins in German surrealism and its development within Latin-America—as well as its theoretical correlation to Charles Baxter’s defamiliarization and Milan Kundera’s appeal of dream—I acknowledge magical realism’s literary techniques and cultural motivations within published fiction. I analyze magical …

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Evaluating Exploitation Of White Crappie And Black Crappie In Three Southeast Kansas Reservoirs, Danci Lee Johnston Jan 2022

Evaluating Exploitation Of White Crappie And Black Crappie In Three Southeast Kansas Reservoirs, Danci Lee Johnston

Graduate Theses/Dissertations

Populations of white crappie Pomoxis annularis and black crappie P. nigromaculatus were studied in three southeast Kansas reservoirs to assess exploitation and determine if current regulations were conducive for sustainable populations. Trap nets were used to sample crappie in Elk City Reservoir, Big Hill Reservoir, and Parsons City Lake. Crappie with length 210 mm and greater were tagged with FloyFD-94 tags that served as entries into a drawing for a US$300-valued reward to encourage tag reporting. Harvest and angler demographic information were collected when tags were reported. Postcard surveys and motion-sensed cameras were used in conjunction to estimate angler effort …

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Effects Of Natural Products On Inflammation, Riley Ann Nadler Jan 2022

Effects Of Natural Products On Inflammation, Riley Ann Nadler

Graduate Theses/Dissertations

Chronic inflammation is characterized by infiltration of inflammatory cells such as macrophages and lymphocytes into the tissue where they produce inflammatory cytokines that contribute to tissue damage. Worldwide, 3 out of 5 people die due to chronic inflammatory diseases like cardiovascular diseases, obesity, diabetes, and cancer. Since it is well-documented that diet and metabolism are key mediators of inflammation, I investigated the effects of dietary lectins on inflammatory cytokine production and the ability of sodium pyruvate, a metabolite, to decrease inflammation. In chapter 1, I examined the effect that lectins from either Triticum vulgaris (common wheat) or Phaseolus vulgaris (common …

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Testing The Impact Of A Silencing Suppressor On Infectivity Of Grapevine Vein Clearing Virus Infectious Clone In Nicotiana Benthamiana, Wen Zhao Jan 2022

Testing The Impact Of A Silencing Suppressor On Infectivity Of Grapevine Vein Clearing Virus Infectious Clone In Nicotiana Benthamiana, Wen Zhao

Graduate Theses/Dissertations

Grapevine vein clearing virus (GVCV), the first DNA virus of the Badnavirus genus discovered in grapevines, is closely associated with grapevine vein-clearing disease. Through earlier research, Koch's postulates were partially met: GVCV was in all diseased plants; GVCV was introduced into a healthy grapevine through grafting and by aphids and caused the disease. However, more shreds of evidence are required to fulfill the last postulate, the same virus must be reisolated from the inoculated diseased grapevine (1). A full-length infectious clone of GVCV was previously constructed to provide evidence; however, its infectivity was not consistent. Therefore, the goal …

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The Politics Of Recognition In Building Pluriversal Possibilities: Posthumanism, Buen Vivir, And Zapatismo, Robert Leston Jan 2022

The Politics Of Recognition In Building Pluriversal Possibilities: Posthumanism, Buen Vivir, And Zapatismo, Robert Leston

Publications and Research

No abstract provided.

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Cultural Heritage And Storytelling: The Role Of Mythology And Folklore In Popular Fictional Novels, Katrina Powers Jan 2022

Cultural Heritage And Storytelling: The Role Of Mythology And Folklore In Popular Fictional Novels, Katrina Powers

A with Honors Projects

An ethnographic paper focusing on how mythology and folklore in popular fictional novels connects readers to cultural heritage.

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Fda As Food System Stewards, Margot J. Pollans, Matthew F. Watson Jan 2022

Fda As Food System Stewards, Margot J. Pollans, Matthew F. Watson

Elisabeth Haub School of Law Faculty Publications

The Food and Drug Administration (“FDA”) is one of the primary regulators of the U.S. food system, yet it all but ignores the food system's vast environmental footprint. Although the agency is not technically an environmental agency, it could and should view redressing the food system's significant environmental footprint as part of its health and safety mission. In this Article, we review FDA's history of National Environmental Policy Act (“NEPA”) compliance. This history affirms our hypothesis that FDA does not view its own work as environmental. The review, along with assessment of some of FDA's core food programs, reveals that …

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A Job-Demand Resource Theory And Psychological Flexibility Integrated Model Of Police Officer Burnout, Lucas David Baker Jan 2022

A Job-Demand Resource Theory And Psychological Flexibility Integrated Model Of Police Officer Burnout, Lucas David Baker

Dissertations and Theses

Police officers encounter stressors as a result of job responsibilities that contribute to high rates of occupational burnout. Defined by three primary components (emotional exhaustion, depersonalization, and professional inefficacy), burnout is associated with health- and work-related problems among officers. In addition, police agencies incur significant costs associated with burnout due to performance decline and turnover. Officer burnout is also a matter of public interest given that burnout is associated with low prosocial behavior and high use of force. As such, research that aims to explore the formation and maintenance of officer burnout may be consequential for the profession and society …

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True Pauline Worship Is Trinitarian: A Look At Paul’S Trinitarian Presuppositions, Connie Heberlein Jan 2022

True Pauline Worship Is Trinitarian: A Look At Paul’S Trinitarian Presuppositions, Connie Heberlein

Masters Theses

This thesis seeks to show that true Pauline worship is Trinitarian. Thus, proper Christian worship must be Trinitarian. This work begins by examining the Shema and exploring the unique identity of God presented in the Old Testament and the literature of Second Temple Judaism. Building on this foundation, this work evaluates statements found in Paul’s letters in which Paul reformulates the Shema to include Christ and the Spirit in the divine identity of God. The goal is to understand how the first Christians, who were Jews committed to the exclusive worship of Yahweh, moved from monotheistic worship to Trinitarian worship …

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We Take Back The Moon, Zoey Jean Adam Jan 2022

We Take Back The Moon, Zoey Jean Adam

Selected Full-Text Master Theses 2021-

My creative manuscript, tentatively known as We Take Back the Moon, is an in-progress fantasy novel in verse. Set in a world not like our own where the only bipedal inhabitants are elves, it is a tale of two best friends contending with a society where those who lack the ability to use magic are sentenced to the Colony—essentially a prison camp. Chkal, one of the protagonists, was a child prodigy in magic and still lives in the Capital, while her best friend, Esari, was sent away at age thirteen to the Colony. The story follows Chkal’s struggle with her …

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A Narrative Study Describing The Transition From Residential Treatment As A Child: An Adult Perspective, Alison Marie Vogelsang Jan 2022

A Narrative Study Describing The Transition From Residential Treatment As A Child: An Adult Perspective, Alison Marie Vogelsang

Dissertations and Theses

To date, the literature sorely lacks empirical research exploring treatment outcomes among children in residential treatment centers (RTCs). Consequentially, there is an increasing demand for more studies examining such outcomes, particularly as they pertain to an individual’s experience leaving an RTC. There is even less research exploring the perspectives of individuals who resided in an RTC as a child due to the vulnerable nature of this population and difficulty in accessibility. The transitional period is believed to be a salient component impacting treatment outcomes, yet little is known about how this component of residential treatment is experienced and whether it …

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Nonhematopoietic Erythropoietin: A Study Of Signaling, Structure, And Behavior, Nicholas John Pekas Jan 2022

Nonhematopoietic Erythropoietin: A Study Of Signaling, Structure, And Behavior, Nicholas John Pekas

Dissertations and Theses

Erythropoietin (EPO) is a cytokine hormone known for initiating red blood cell proliferation by binding to its homodimer receptor (EPOR)2 in the bone marrow. Recent progress in neurobiology has shown that EPO also exerts robust neurotrophic and neuroprotective activity in the CNS. It is widely thought that EPO’s neurotrophic activity is centrally involved in its antidepressant and cognitive enhancing effects. However, EPO’s potent erythropoietic effects prevent it from being used in the clinic to treat psychiatric disorders. A chemically engineered non-erythropoietic derivative of EPO, carbamoylated EPO (CEPO), produces psychoactive effects without activating hematopoiesis. However, CEPO is expensive to produce and …

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Single Cell Lineage Tracing Reveals Mechanisms Of Tumor Initiation And Chemoresistance In Small Cell Lung Cancer, Hannah Wollenzien Jan 2022

Single Cell Lineage Tracing Reveals Mechanisms Of Tumor Initiation And Chemoresistance In Small Cell Lung Cancer, Hannah Wollenzien

Dissertations and Theses

Small Cell Lung Cancer (SCLC) is a devastating disease characterized by a very low two-year survival rate and almost universal acquisition of chemoresistance. Nearly all patients have tumors driven by functional inactivation of the tumor suppressors Rb and p53, but despite the uniform origins of this tumor, not all patients are genetically or phenotypically identical. SCLC can be subtyped into four unique molecular subtypes, determined by the expression of ASCL1, NEUROD1, POU2F3, or YAP1. These subtypes are plastic, and subtype switching after chemotherapy has been documented. Without the understanding of how tumor heterogeneity arises, we cannot solve the challenge of …

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User Experience In The Visual Notifications On Smart Devices, Young Ae Kim Jan 2022

User Experience In The Visual Notifications On Smart Devices, Young Ae Kim

Dissertations and Theses

Notifications on smart devices have a crucial role for the end-users to help decide their action to the information. Despite the flexible customization of notifications for the intuitive user experience, users feel overwhelmed by the number of notifications they receive daily. The nature of notifications is short-lived, but they are extremely intrusive and disengaging. While user experience and user interface are advanced, notifications have remained broken despite their complexity. In fact, the notifications have the poorest usability that users may struggle to customize notifications in their smart devices and choose to ignore them. Irrelevant notifications not only get ignored, but …

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Disruption Of Cholesterol Biosynthesis Contributes To Glial Dysfunction And Disturbs Astrocyte-Microglia Crosstalk, Bethany Ann Freel Jan 2022

Disruption Of Cholesterol Biosynthesis Contributes To Glial Dysfunction And Disturbs Astrocyte-Microglia Crosstalk, Bethany Ann Freel

Dissertations and Theses

The brain is the most cholesterol rich organ in the body, containing ~25% of the body’s total cholesterol content. Due to the blood-brain barrier, cholesterol in the brain is primarily synthesized de novo by astrocytes and transported to neurons. Genetic disorders of cholesterol biosynthetic enzymes result in reduced CNS cholesterol levels and sterol precursor accumulation. Smith-Lemli-Opitz syndrome (SLOS) is caused by mutations in 7-dehydrocholesterol reductase (DHCR7), which is responsible for the reduction of 7- DHC to cholesterol in the final step of the cholesterol biosynthesis pathway. SLOS results in broad neurodevelopmental malformations and neurological deficits. While much work has focused …

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Affective Dependence, Self-Regulation, And Alcohol-Related Problems: Between- And Within-Person Associations, Kyle James Walters Jan 2022

Affective Dependence, Self-Regulation, And Alcohol-Related Problems: Between- And Within-Person Associations, Kyle James Walters

Dissertations and Theses

This study sought to elucidate the role of affective dependence (i.e., PA-NA correlation) as a predictor of goal pursuit and alcohol-related problems at the within- and between-person levels and trait urgency at the between-person level. Affective dependence, that is, the extent to which PA and NA are correlated, may be a marker for self-regulation on the one hand (weaker dependence) and impulsivity on the other (stronger dependence). Importantly, the association between PA and NA varies both within and between individuals (Dejonckheere et al., 2019; Zautra et al., 2001). I designed and implemented an intensive longitudinal study to test hypotheses that …

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Embodied Intelligence: Smooth Coping In The Learning Intelligent Decision Agent (Lida) Cognitive Architecture, C. Kronsted, S. Kugele, Z. Neemeh, K. Ryan, S. Franklin Jan 2022

Embodied Intelligence: Smooth Coping In The Learning Intelligent Decision Agent (Lida) Cognitive Architecture, C. Kronsted, S. Kugele, Z. Neemeh, K. Ryan, S. Franklin

CCRG Papers

No abstract provided.

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Representing Transition Experiences: A Multimodal Critical Discourse Analysis Of Young Immigrants In Children’S Literature, Xiaoyan Gu, Theresa Catalano Jan 2022

Representing Transition Experiences: A Multimodal Critical Discourse Analysis Of Young Immigrants In Children’S Literature, Xiaoyan Gu, Theresa Catalano

Department of Teaching, Learning, and Teacher Education: Faculty Publications

Because literature can serve as a mirror for children’s self-reflection and a window into humanizing insights on immigrants and immigration, it can be a powerful educational tool to promote understanding of immigrant learner’s experiences and needs. However, this has not always been the case. As such, informed by our theoretical framework of critical discourse studies (CDS) and raciolinguistics, this study explores the representations of immigrant children’s experiences in children’s literature. Employing multimodal critical discourse analysis, the authors analyze the visual and verbal representations of immigrant children (and the ideologies behind them) in 18 picture books with immigration themes. Findings reveal …

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Composted Sewage Sludge Application Reduces Mineral Fertilization Requirements And Improves Soil Fertility In Sugarcane Seedling Nurseries, Rafael Dos Santos Silva, Arshad Jalal, Raimunda Eliane Nascimento Do Nascimento, Nathércia Castro Elias, Karen Cossi Kawakami, Cassio Hamilton Abreu-Junior, Fernando Carvalho Oliveira, Arun Dilipkumar Jani, Zhenli He, Fengliang Zhao, Marcelo Carvalho Minhoto Teixeira Filho, Raffaella Rossetto, Gian Franco Capra, Thiago Assis Rodrigues Nogueira Jan 2022

Composted Sewage Sludge Application Reduces Mineral Fertilization Requirements And Improves Soil Fertility In Sugarcane Seedling Nurseries, Rafael Dos Santos Silva, Arshad Jalal, Raimunda Eliane Nascimento Do Nascimento, Nathércia Castro Elias, Karen Cossi Kawakami, Cassio Hamilton Abreu-Junior, Fernando Carvalho Oliveira, Arun Dilipkumar Jani, Zhenli He, Fengliang Zhao, Marcelo Carvalho Minhoto Teixeira Filho, Raffaella Rossetto, Gian Franco Capra, Thiago Assis Rodrigues Nogueira

Biology, Agriculture and Chemistry Faculty Publications and Presentations

Sugarcane demands large amounts of nutrients to reach a high level of productivity. Nutrients are generally supplied by mineral fertilizers, but their high costs and negative environmental impacts have generated interest in greater use of organic nutrient sources such as composted sewage sludge (CSS). In this study, we evaluated changes in soil chemical properties after the application of CSS or CSS/mineral fertilizer (MF) combinations to soil containing sugarcane seedlings under nursery conditions. Treatments included: T1: conventional mineral fertilization (MF) without application of CSS, T2: 100% of the recommended MF (06–30–24); T3: application of 2.5 Mg−1 CSS; T4: 5.0 Mg−1 CSS, …

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