Digital Commons Network^™

Murine Roseolovirus Does Not Accelerate Amyloid-Β Pathology And Human Roseoloviruses Are Not Over-Represented In Alzheimer Disease Brains, Tarin M Bigley, Monica Xiong, Muhammad Ali, Yun Chen, Chao Wang, Javier Remolina Serrano, Abdallah Eteleeb, Oscar Harari, Liping Yang, Swapneel J Patel, Carlos Cruchaga, Wayne M Yokoyama, David M Holtzman

2020-Current year OA Pubs

BACKGROUND: The role of viral infection in Alzheimer Disease (AD) pathogenesis is an area of great interest in recent years. Several studies have suggested an association between the human roseoloviruses, HHV-6 and HHV-7, and AD. Amyloid-β (Aβ) plaques are a hallmark neuropathological finding of AD and were recently proposed to have an antimicrobial function in response to infection. Identifying a causative and mechanistic role of human roseoloviruses in AD has been confounded by limitations in performing in vivo studies. Recent -omics based approaches have demonstrated conflicting associations between human roseoloviruses and AD. Murine roseolovirus (MRV) is a natural murine pathogen …

Principles Of Hypotensive Shock: A Video Introduction To Pathophysiology And Treatment Strategies, Brittany Macdonald, Nicholas Macdonald, Jacob Garcia, Xiao Chi Zhang, Dimitrios Papanagnou

Department of Emergency Medicine Faculty Papers

Audience: Emergency medicine interns, medical students, and mid-level providers (physician assistants, nurse practitioners).

Introduction: Shock is defined as a state of global tissue hypoxia and is typically the result of hypotension and circulatory system failure. A variety of disease states may ultimately culminate in hypotensive shock through one or more generally recognized mechanisms – hypovolemic, cardiogenic, obstructive, and/or distributive shock. These mechanisms differ significantly in terms of their pathophysiology and requisite treatment. While the effects of hypotensive shock are initially reversible, untreated hypotensive shock may rapidly progress to multiorgan failure and death. Hence, the ability to promptly recognize a state …

Clonal Hematopoiesis Mutations In Patients With Lung Cancer Are Associated With Lung Cancer Risk Factors, Wei Hong, Ang Li, Yanhong Liu, Xiangjun Xiao, David C Christiani, Rayjean J Hung, James Mckay, John Field, Christopher I Amos, Chao Cheng

Faculty, Staff and Students Publications

Clonal hematopoiesis (CH) is a phenomenon caused by expansion of white blood cells descended from a single hematopoietic stem cell. While CH can be associated with leukemia and some solid tumors, the relationship between CH and lung cancer remains largely unknown. To help clarify this relationship, we analyzed whole-exome sequencing (WES) data from 1,958 lung cancer cases and controls. Potential CH mutations were identified by a set of hierarchical filtering criteria in different exonic regions, and the associations between the number of CH mutations and clinical traits were investigated. Family history of lung cancer (FHLC) may exert diverse influences on …

The Relevance Of The Five New Laws Of Librarianship To The Development Of Mosque Libraries In Indonesia, Ahmad Amir Aziz

Library Philosophy and Practice (e-journal)

In today's world of information technology disruption, library science must adapt quickly and accurately. The true library will always play an important role as a center of knowledge, including the mosque library, which is a distinct type of library because the majority of its collections are religious in nature. This article intends to discuss the New Five Laws of Librarianship as proposed by Michael Gorman, who revised the Ranganathan concept. The concept will be tested to determine its applicability to the design of the mosque library development, which is tasked with providing services to the surrounding Muslim community. Gorman's principle …

Usage Of E-Resources By The Users Of The Agricultural University Libraries In India, Monisha Mishra, Dr. Krushna Chandra Panda

Library Philosophy and Practice (e-journal)

This paper, a part of the author’s doctoral research, examines the various e-resources to which the users of Agricultural Universities in India have access and how frequently these resources are being used by agricultural scientists, researchers, students. Data collected through a structured questionnaire from 242 users and 20 Librarians from 20 State-run Agricultural Universities in India constitute the database for the present investigation. Additionally, the study also investigates the membership of various consortiums availed by the users and whether the respondents have access to some of the key e-resources of other institutions including frequency of usage of subject gateways, blogs …

Analysis Of Ensiling Suitability Of Moringa, A Woody Plant, Z. Du, F. Yang, Y. Lin, Y. Cai

IGC Proceedings (1977-2023)

To effectively use the woody plant resources as animal feed, the ensiling suitability of Moringa including the dynamics of microbial community, chemical composition, and silage fermentation were studied. Tender stems and leaves of Moringa at the full-bloom stage of second cutting was used for silage preparation in Guizhou, China. After 3, 7, 15, 30, and 60 days of ensiling, five silos for each treatment were opened to analyze the fermentation characteristics. Moringa before ensiling contained 10⁴ lactic acid bacteria (LAB), 10⁶ aerobic bacteria, 10⁴ coliform bacteria, 10² yeast, and 10⁴ mold based on colony-forming unit/g …

Impact Of Grazing Management On Productivity Of Tropical Grasslands, Moacyr Corsi, Geraldo B. Martha Jr., Domício Do Nascimento Jr., Marco A. A. Balsalobre

IGC Proceedings (1977-2023)

Beef and dairy cattle enterprises from tropical pasture-based systems are notoriously of low productivity. The low soil fertility, the exploitation of native grasslands, the low genetic potential of the animals and the poor management of soil, pasture and animal components are all arguments used to explain these “low-productivity systems”. In fact, research has consistently indicated up to 50% increase in calving rate when animals grazing unfertilized pastures were supplemented with trace-mineralized salt (Table 1) but unfortunately less than 90% of Brazilian farmers use this management strategy (Tosi, 1997). However, a recent survey conducted by São Paulo State government showed that …

Impact Of Grazing Management On The Productivity Of Cold Temperate Grasslands Of Southern Patagonia - A Critical Assessment, A. F. Cibils, M. B. Coughenour

IGC Proceedings (1977-2023)

The contention that productivity of cold temperate grasslands of southern Patagonia have been greatly affected by domestic herbivore grazing in the past is fairly widespread. The consequences of spatiotemporal interactions between grazing and abiotic factors on the overall productivity of such systems, however, are still poorly understood. Predictions of both short- and long-term impacts of grazing management strategies on grassland productivity require a better understanding of these interactions. In this paper we make a critical assessment of the impact of grazing management on long-term sustainability of the grass steppes of southern Patagonia (Argentina). We discuss this issue in the context …

Productivity Of Winter And Spring Native Improved Vegetation Under Different Grazing Stocking Rates On Basaltic Soil, M. Bemhaja

IGC Proceedings (1977-2023)

Improved grassland with Lotus corniculatus, Trifolium repens and annual phosphorus fertilization, was evaluated during winter and spring for five consecutive years under grazing at three different stocking rates on medium basaltic soil. Specific contribution of Lotus and Trifolium reached 67% of grassland community in the first year. Stipa setigera and Poa lanigera increased their contribution from 0.8 to 17% in the fourth year of grazing experiment. Highest average value of crude protein was 19% during the second year and was related to legumes contribution. Forage availability was always up to 1.5 ton MS/ha at the three stocking treatments. Average daily …

Effects Of Cattle Grazing On A Perennial Legume, Bitumen Trefoil (Bituminaria Bituminosa (L.) Stirton), In A Mediterranean Grassland, M. Gutman, M. Sternberg, A. Perevoltsky

IGC Proceedings (1977-2023)

A six-year study was conducted in a Mediterranean grassland in north-eastern Israel to investigate the effects of cattle grazing management on a perennial legume, Bitumen Trefoil (Bituminaria bituminosa (L.) Stirton). The relationship between grazing pressure and its relative plant cover was studied in the context of inter-annual variation in rainfall. Treatments included manipulations of stocking rates (moderate, heavy and very heavy) and of grazing regimes (continuous vs. seasonal), in a factorial design. The results showed that inter-seasonal rainfall variation was a dominant factor in the expression of plant cover changes of this species. Grazing showed no significant effect on …

Benefit-Cost Analysis Of Flood Management, A Case Study Of Jammu And Kashmir, Kowser Ali Jan, R. Balaji, Khairi Mohamad Omar

Information Sciences Letters

This paper focuses on the cost-benefit analysis (CBA) of flood management by District Disaster Management Kulgam. The assessment is based on secondary pooled data collected from government offices, NGOs, journals, and national newspapers. We describe the scenario, the approach adopted, and sources of flood damage cost information. The estimated total benefits account for 78686.18 lakh rupees, and total costs account for 2218.75lakh rupees. The Benefit-Cost ratio greater than one shows that Flood Management in District Kulgam was economically feasible and successfully managed. The State of Jammu and Kashmir takes essential prevention and management measures to bring down the damages due …

Effects Of Environmental Gradients On The Abundance And Diversity Of Helminths Across 7 Bison Herds In The Upper Midwest, Bradly Wehus-Tow, Jeff M. Martin, Jameson Brennan

SDSU Beef Day 2022 Summary Publication

Study Description:

Data were collected from Wind Cave National Park and 6 satellite bison herds across the upper Midwest ranging across South Dakota, Indiana, and Kansas with a MAP gradient ranging from 34 to 82 mm and a MAT gradient ranging from 9 to 13°C. Fecal samples were collected non-invasively from 50 freshly voided bison dung patties at each herd. Helminth eggs were recovered and identified using sugar floatation; Trichostrongyle-type eggs were hatched by coproculture to identify to species. Preliminary findings indicate that general abundance of trichostrongyle-type helminths increases by 2.3 EPG per 1°C and by 0.2 EPG per mm, …

Rehabilitation/Recovery Journals, Judy Schmitt

Library Faculty Works

Comprehensive list of rehabilitation/recovery journals

Generation And Application Of Inducible Chimeric Rna, Yichen Luo, Liang Du, Zhimeng Yao, Fan Liu, Kai Li, Feifei Li, Jianlin Zhu, Robert P Coppes, Dianzheng Zhang, Yunlong Pan, Shegan Gao, Hao Zhang

PCOM Scholarly Works

Chimeric RNAs (chiRNAs) play many previously unrecognized roles in different diseases including cancer. They can not only be used as biomarkers for diagnosis and prognosis of various diseases but also serve as potential therapeutic targets. In order to better understand the roles of chiRNAs in pathogenesis, we inserted human sequences into mouse genome and established a knockin mouse model of the tamoxifen-inducible expression of ASTN2-PAPPA antisense chimeric RNA (A-PaschiRNA). Mice carrying the A-PaschiRNA knockin gene do not display any apparent abnormalities in growth, fertility, histological, hematopoietic, and biochemical indices. Using this model, we dissected the role of …

The International Adjudication Of Mega-Politics, Karen J. Alter, Mikael Rask Madsen

Law and Contemporary Problems

No abstract provided.

Community Acknowledgment: Engaging Community Members In Volunteer Acknowledgment, Fanlu Gui, Chun-Hua Tsai, John Millar Carroll

Information Systems and Quantitative Analysis Faculty Publications

Volunteers in non-profit groups are a valuable workforce that contributes to economic development and supports people in need in the U.S. However, many non-profit groups face challenges including engaging and sustaining volunteer participation, as well as increasing visibility of their work in the community. To support non-profit groups' service, we explored how engaging community members in the volunteer-acknowledgment process may have an impact. We set up workstations and invited community members to write thank-you cards to volunteers in non-profit groups. We conducted 14 interviews with volunteers and community members, collected and analyzed 25 thank-you cards. We found that the acknowledgment …

Highly-Individualized Physical Therapy Instruction Beyond The Clinic Using Wearable Inertial Sensors, Samir A. Rawashdeh, Ella Reimann, Timothy L. Uhl

Physical Therapy Faculty Publications

Musculoskeletal conditions, often requiring rehabilitation, affect one-third of the U.S. population annually. This paper presents rehabilitation assistive technology that includes body-worn motion sensors and a mobile application that extends the reach of a physical rehabilitation specialist beyond the clinic to ensure that home exercises are performed with the same precision as under clinical supervision. Assisted by a specialist in the clinic, the wearable sensors and user interface developed allow the capture of individualized exercises unique to the patient’s physical abilities. Beyond the clinical setting, the system can assist patients by providing real-time corrective feedback to repeat these exercises through a …

Volume Cxxxx, Number 1, January 14, 2022, Lawrence University

The Lawrentian

No abstract provided.

Repertorio Estético-Afectivo De Hombres Anti-Patriarcales: La Construcción De Otras Masculinidades, Jorge A. Jimenez Rodas, Juan C. Arboleda-Ariza, Milton D. Morales Herrera

The Qualitative Report

Los estudios de género en hombres y masculinidades retoman las bases de la crítica feminista para analizar los procesos y subjetividades masculinas. Este proceso ha estado acompañado de la creación cada vez más visible de colectivos de hombres que se oponen a los marcos hegemónicos de la masculinidad y promueven, por medio de un activismo político, versiones alternativas de entender lo masculino. En este trabajo nos preguntamos por el discurso que utilizan estos hombres y las consecuencias de este. Para esto analizamos el discurso de doce hombres latinoamericanos que participan en estos grupos e identificamos a partir de la variabilidad …

Harnessing Mycobacterium Bovis Bcg Trained Immunity To Control Human And Bovine Babesiosis, Reginaldo G. Bastos, Heba F. Alzan, Vignesh A. Rathinasamy, Brian M. Cooke, Odir A. Dellagostin, Raul G. Barletta, Carlos E. Suarez

School of Veterinary and Biomedical Sciences: Faculty Publications

Babesiosis is a disease caused by tickborne hemoprotozoan apicomplexan parasites of the genus Babesia that negatively impacts public health and food security worldwide. Development of effective and sustainable vaccines against babesiosis is currently hindered in part by the absence of definitive host correlates of protection. Despite that, studies in Babesia microti and Babesia bovis, major causative agents of human and bovine babesiosis, respectively, suggest that early activation of innate immune responses is crucial for vertebrates to survive acute infection. Trained immunity (TI) is defined as the development of memory in vertebrate innate immune cells, allowing more efficient responses to subsequent …

Volume 119, Number 5, Friday, January 14th, 2022, Saint Mary's College Of Califiornia

The Collegian

No abstract provided.

Molecular Characterization Of Antibiotic Resistant Shiga Toxin-Producing Escherichia Coli From Clinical And Food Samples, Khulud Alotaibi

Theses and Dissertations

Antimicrobial resistance (AMR) in foodborne pathogens can be a consequence of using antimicrobial drugs in food-producing animals. The emergence of antimicrobial resistance in foodborne pathogens is of great concern due to adverse patient health outcomes and the possibility of transferring genes encoding AMR to other clinically relevant pathogens. One of these bacteria is Shiga toxin-producing Escherichia coli (STEC), which can cause serious illness in humans for a haemolytic uremic syndrome (HUS). This study characterized and determined the mechanism of antibiotic resistance in 46 Shiga toxin-producing Escherichia coli strains collected by the U.S. Food and Drug Administration from food and clinical …

Crassostrea Gigas Invasion In Southern California: Macrofaunal Diversity And Local Community Impacts Of Ecosystem Engineers On Estuarine Habitats, Noah Jansen-Yee

Theses

Many marine ecosystems are facing the growing threat of biological invasions. These invasions can have a variety of different impacts on ecosystems and their inhabitants. The Pacific oyster, Crassostrea gigas, is currently in the relatively early stages of invasion in San Diego estuaries. Crassostrea gigas is a large, filter-feeding bivalve that forms dense oyster beds on hard substrate. These oysters are known to outcompete native counterparts and drastically alter habitats where they are present. Crassostrea gigas is an ecosystem engineer that, through shell creation and formation of a dense oyster matrix, impacts ecosystems in a variety of direct and indirect …

Review On Applications Of Lignin In Pavement Engineering: A Recent Survey, Hui Yao, Yiran Wang, Junfu Liu, Mei Xu, Pengrui Ma, Jie Ji, Zhanping You

Michigan Tech Publications, Part 1

Lignin is the second-largest plant polymer on Earth after cellulose. About 98% of lignin produced in the papermaking and pulping industry is used for combustion heating or power generation. Less than 2% of lignin is used in more valuable fields, mainly in the formulation of dispersants, adhesives, and surfactants. Asphalt is one of the most important materials in pavement engineering. It is a dark brown complex mixture composed of hydrocarbons with different molecular weights and their non-metallic derivatives. Because the chemical structure of lignin is similar to that of asphalt, it is a carbon-based hydrocarbon material. More researchers studied the …

Total Water Column Analysis Shows The Importance Of A Single Species In Subsurface Chlorophyll Maximum Thin Layers In Stratified Waters, Michelle L. Barnett, Alan E.S. Kemp, W. Alex M. Nimmo-Smith, Duncan A. Purdie

School of Biological and Marine Sciences

Marine phytoplankton form the base of marine food webs and are the driving force of the marine carbon cycle, so understanding the dynamics of their blooms is critical. While near-surface marine productivity (<10 m water depths) is extensively documented, that of the subsurface is less well characterised. Increasing evidence of the importance of subsurface chlorophyll maxima (SCM) and climatically driven increases in stratification of surface waters that promote SCM development call for improved sampling of the subsurface. To address this, we targeted the summer stratified waters of the Western English Channel, part of the NW European shelf seas, where SCM are commonly developed. In situ holography was applied to undertake the highest ever resolution, total water column, quantitative analysis of microplankton distribution, and demonstrated the importance of a SCM, co-located with the thermocline, dominated by a single species, the dinoflagellate Ceratium fusus. This species was dominant in the SCM over a wide area of the NW European shelf in the June/July 2015 study period and comprised up to 85% of the SCM biomass. Analysis of similarity and multivariate non-metric multidimensional scaling showed the phytoplankton community of the SCM to be statistically distinct from those of the surface and deep waters. Holography also revealed a fine scale layering of taxa at different levels within the SCM, likely reflecting ecological differences. Some taxa followed the peak abundance of C. fusus, while others reached maximum abundances immediately below or above the C. fusus maximum, suggesting the possible operation of exclusion mechanisms. Additionally, the detection of abundant aggregates located only within and beneath the SCM demonstrates the potential importance of this deep production for the export of carbon to the sea floor. Some predictions of phytoplankton productivity propose a shift to smaller cells in the more stratified oceans of the future resulting in declining production and export. Results presented here, however, contribute to a growing body of evidence that suggests, on the contrary, that key species among the larger celled/colonial, SCM-adapted diatoms and dinoflagellates may instead be selected in stratified conditions, driving increased production and export.

Nipah Virus V Protein Binding Alters Mda5 Helicase Folding Dynamics, Nicole D Wagner, Hejun Liu, Henry W Rohrs, Gaya K Amarasinghe, Michael L Gross, Daisy W Leung

2020-Current year OA Pubs

Nipah virus (NiV) is an emerging and deadly zoonotic paramyxovirus that is responsible for periodic epidemics of acute respiratory illness and encephalitis in humans. Previous studies have shown that the NiV V protein antagonizes host antiviral immunity, but the molecular mechanism is incompletely understood. To address this gap, we biochemically characterized NiV V binding to the host pattern recognition receptor MDA5. We find that the C-terminal domain of NiV V (V

Novel Mouse Model Of Murine Cytomegalovirus-Induced Adaptive Nk Cells, Isaac J Jensen, Matthew D Martin, Sandeep K Tripathy, Vladimir P Badovinac

2020-Current year OA Pubs

NK cells are important mediators of viral control with the capacity to form adaptive immune features following infection. However, studies of infection-induced adaptive NK cells require adoptive cell transfer to lower the precursor frequency of "Ag-specific" NK cells, potentially limiting the diversity of the NK cell response. In seeking an unmanipulated model to probe the adaptive NK cells, we interrogated a wide range of Collaborative Cross (CC) inbred mice, inbred mouse strains that exhibit broad genetic diversity across strains. Our assessment identified and validated a putative "ideal" CC strain, CC006, which does not require manipulation to generate and maintain adaptive …

Increased Above-Ground Biomass And Plant Species Decline Related To The Presence Of Eragrostis Curvula Across Multiple Grazing Grasslands In The Snowy Monaro Region Of Australia, J. Brown, L. Ingram

IGC Proceedings (1977-2023)

"It will be noticed that invasions most often come to cultivated land, or to land much modified by human practice." This quote was published in 1958 by Charles Elton, and holds true today, backed by empirical evidence suggesting mechanisms of disturbance, plant functional traits and propagule pressure can push a cultivated system towards an invaded state. 17 farms, with either a current or previous history of grazing and land modification, within the Snowy Monaro Region, NSW, Australia, were surveyed to explore the relationship between the non-native C4 perennial tussock grass Eragrostis curvula [Schrad.] Nees. and species richness. As E. curvula …

The Use Of Open Communal Grazing Designs To Screen Options For Grazing Management, David R. Kemp, D. L. Michalk, P. M. Dowling, G. Millar

IGC Proceedings (1977-2023)

An open communal grazing design is described that enables a large number of grazing tactics to be concurrently evaluated in small plots under common grazing conditions. Pasture data indicated that the same level of utilisation occurred inside the experimental plots as in the surrounding field. However, differential grazing may occur where plots have divergent composition. The open communal design was economical using < 5% of the land, livestock and fencing resources of alternative designs. The limitations of the open communal design as a research tool are also discussed.

Stocking Rate And Supplementation Effects On Performance Of Lambs Grazing Triticale And Ryegrass Sward In Uruguay, R. San Julián, Fabio Montossi, L. Guarino, F. Pittaluga

IGC Proceedings (1977-2023)

An experiment was carried out from 9 June to 2 October 1997, using a Lolium multiflorum Lom. (Ryegrass) and X Triticosecale Wittmack (triticale) sward to evaluate the effect of stocking rate (SR; 20, 30 and 40 lambs/ha), and supplementation (S; with or without) on Corriedale lamb performance. SR had a significant effect on: liveweight gain (160, 130 and 90 g/an/d, P< 0.01); greasy fleece weight (2.8, 2.7 and 2.3 kg, P< 0.01); fiber diameter (28, 27, and 26 microns, P< 0.05); rib eye depth (2.4, 2.1 and 2.0 cm, P< 0.05); fat cover (3.2, 2.1 and 1.5 cm, P< 0.01); hot carcass weight (17.7, 15.6 and 13.5 kg/an, P< 0.01); GR (10.5, 6.6 and 4.2 mm, P< 0.01) and boneless leg weight (1.56, 1.42 and 1.24 kg, P< 0.05), for 20, 30 and 40 lambs per ha, respectively. At the highest SR, lambs increased grazing time (59 vs 52%) and biting rate (29 vs 26 bites/lamb/min). The mayor influence of S on lamb performance was found in grazing behavior variables: (grazing time (63 vs 50%, P< 0.01); biting rate (26.8 vs 28.4 bites/lamb/min, P< 0.01)), carcass characteristics: (hot carcass weight (15.3 vs 16.0 kg, P< 0.05); GR (7.9 and 6.3 mm, P< 0.05)) for with and without supplement, respectively. Over the experimental period (115 days), liveweight production and wool production ranged from 358 to 437 kg/ha for 20 and 30 lambs/ha respectively, and wool production from 55 to 93 kg/ha for 20 and 40 lambs/ha respectively. These results show the potential use of mixed ryegrass and triticale swards to produce high quality lamb meat even at high SRs, and the convenience of using supplements only when sward conditions are not sufficient to maintain an adequate lamb performance, particularly when high lamb SRs are used.