Digital Commons Network^™

Whole-Genome Sequence And Interaction Analysis In The Production Of Six Enzymes From The Three Bacillus Strains Present In A Commercial Direct-Fed Microbial (Norum™) Using A Bliss Independence Test, Daniel Hernandez-Patlan, Bruno Solis-Cruz, Juan D. Latorre, Ruben Merino-Guzman, Miguel Morales Rodriguez, Catie Ausland, Xochitl Hernandez-Velasco, Oscar Ortiz Holguin, Ramiro Delgado, Billy Hargis, Pallavi Singh, Guillermo Tellez-Isaias

Poultry Science Faculty Publications and Presentations

The three Bacillus strains present in Norum™ were initially selected by their excellent to good relative enzyme activity (REA) production score for amylase, protease, lipase, phytase, cellulase, β-glucanase, and xylanase. Further studies confirmed that the three isolates also showed an antibacterial activity, Gram-positive and Gram-negative poultry pathogens. Norum™ (Eco-Bio/Euxxis Bioscience LLC) is a Bacillus spore direct-fed microbial (DFM). The Bacillus isolates were screened and selected based on in vitro enzyme production profiles. Moreover, in chickens fed high non-starch polysaccharides, this DFM demonstrated to reduce digesta viscosity, bacterial translocation, increase performance, bone mineralization, and balance the intestinal microbiota. In the present …

Probiotics, Prebiotics, And Phytogenic Substances For Optimizing Gut Health In Poultry, Awad A. Shehata, Sakine Yalçın, Juan D. Latorre, Shereen Basiouni, Youssef A. Attia, Amr Abd El-Wahab, Christian Visscher, Hesham R. El-Seedi, Claudia Huber, Hafez M. Hafez, Wolfgang Eisenreich, Guillermo Tellez-Isaias

Poultry Science Faculty Publications and Presentations

The gut microbiota has been designated as a hidden metabolic 'organ' because of its enormous impact on host metabolism, physiology, nutrition, and immune function. The connection between the intestinal microbiota and their respective host animals is dynamic and, in general, mutually beneficial. This complicated interaction is seen as a determinant of health and disease; thus, intestinal dysbiosis is linked with several metabolic diseases. Therefore, tractable strategies targeting the regulation of intestinal microbiota can control several diseases that are closely related to inflammatory and metabolic disorders. As a result, animal health and performance are improved. One of these strategies is related …

Developing Novel Therapies For Degenerative Cervical Myelopathy [Ao Spine Recode-Dcm Research Priority Number 7]: Opportunities From Restorative Neurobiology., Aref-Ali Gharooni, Brian K Kwon, Michael G Fehlings, Timothy F Boerger, Ricardo Rodrigues-Pinto, Paul Aarne Koljonen, Shekar N Kurpad, James Harrop, Bizhan Aarabi, Vafa Rahimi-Movaghar, Jefferson R Wilson, Benjamin M Davies, Mark R N Kotter, James D Guest

Department of Neurosurgery Faculty Papers

Study design: Narrative review.

Objectives: To provide an overview of contemporary therapies for the James Lind Alliance priority setting partnership for degenerative cervical myelopathy (DCM) question: 'Can novel therapies, including stem-cell, gene, pharmacological and neuroprotective therapies, be identified to improve the health and wellbeing of people living with DCM and slow down disease progression?'

Methods: A review of the literature was conducted to outline the pathophysiology of DCM and present contemporary therapies that may hold therapeutic value in 3 broad categories of neuroprotection, neuroregeneration, and neuromodulation.

Results: Chronic spinal cord compression leads to ischaemia, neuroinflammation, demyelination, and neuronal loss. Surgical …

A New Prescription For The Opioid Epidemic: 360- Degree Accountability For Pharmaceutical Companies And Their Executives, Rebecca A. Delfino

UC Law Journal

We can no longer ignore this—a national crisis resulting in almost one million American deaths, costing hundreds of millions of dollars, ravaging the health care system, and devastating state and local communities. This narrative describes the COVID-19 pandemic and something else: the epidemic of opioid addiction and abuse. In the last twenty years, the opioid epidemic claimed the lives of more than 700,000 people at the cost of more than 500 billion dollars to the economy. The COVID-19 pandemic has made the opioid epidemic worse, causing a staggering increase in opioid-related overdose deaths. Even now, on average, 140 people die …

Dean's Update, February 2022, Jerry L. Nadler

SOM Dean's Research Newsletter

No abstract provided.

Perceptions Of Community Among Dual Credit Students Taking Stem Courses Offered Through A Community College, Teresa M. Johnson

Doctoral Dissertations and Projects

The United States is currently experiencing a shortage of qualified individuals to fill jobs in the fields of science, engineering, mathematics, and technology. Therefore, educational institutions are concerned with recruiting and retaining students in these fields of study. One means of introducing students to these fields of study is enrollment in dual credit coursework. The purpose of this quantitative, correlational study was to determine whether a relationship exists between student perceptions of community for dual credit students enrolled in these courses through a local community college and end of term averages in these courses. This relationship was examined by collecting …

A Biomimetic Model For Oxidative Metabolism Of Thiopurine Drugs, Oluyemi Oludare Alo

Dissertations and Theses

Type B hepatotoxicity has been reported for thiopurines, and this has limited their clinical uses. Although a lot of research has been done on thiopurines, the precise mechanism of their hepatotoxicity is still unclear. The results of the in vitro and in vivo experiments aimed at assessing the products of their CYP450-mediated bioactivation have been contradictory. Although it has been theorized that the hepatic toxicity of this class of drug is caused by their bioactivation to electrophilic reactive metabolite (RM) and concomitant protein binding to form immunogenic adducts, resulting in direct cellular dysfunction or an immune response via the formation …

Mental Construal And Alterations In Emotional Memory, Olivia D. Beers

Dissertations

Psychological distancing refers to a shift from a psychologically immersed perspective that involves thinking about the details of an event (concretely) or stepping back from it and watching the event from an outside point of view (abstractly)––this can help individuals change how they feel about the experience. Investigating how construal levels affect emotional memories may provide more insight into how individuals may potentially alter the recall of their memories. The current study reflects a new examination of the effect of primed high and low construal levels on the recall of positive and negative arousing stimuli. This study included a pilot …

Role Of Simulation In Open Varicose Veins Surgery: A Systematic Review, Muhammad Ammar Pirzada, Fareed Ahmed Shaikh, Shoaib Badini, Nadeem Ahmed Siddiqui

Department of Surgery Docs

Objective: To assess the types and effectiveness of simulators present for open varicose vein surgery.
Methods: The systematic review was conducted at The Aga Khan University Hospital Karachi and comprised studies published from 1st January 2000 to 30th June 2020 related to open varicose vein surgical procedures done on simulators. Databases searched were PubMed, Medline, Google Scholar, Cochrane and Scopus using appropriate key words. The primary outcome of the review was to assess the effectiveness of different types of simulators used for varicose vein surgery.
Results: Of the 286 articles found, 6(2%) were included. A variety of simulators ranging from …

Desiring Jesus: Ellen White And Worship, David A. Williams

Faculty Publications

No abstract provided.

Extensive Identification Of Genes Involved In Congenital And Structural Heart Disorders And Cardiomyopathy, Nadine Spielmann, Gregor Miller, Tudor I Oprea, Chih-Wei Hsu, Gisela Fobo, Goar Frishman, Corinna Montrone, Hamed Haseli Mashhadi, Jeremy Mason, Violeta Munoz Fuentes, Stefanie Leuchtenberger, Andreas Ruepp, Matias Wagner, Dominik S Westphal, Cordula Wolf, Agnes Görlach, Adrián Sanz-Moreno, Yi-Li Cho, Raffaele Teperino, Stefan Brandmaier, Sapna Sharma, Isabella Rikarda Galter, Manuela A Östereicher, Lilly Zapf, Philipp Mayer-Kuckuk, Jan Rozman, Lydia Teboul, Rosie K A Bunton-Stasyshyn, Heather Cater, Michelle Stewart, Skevoulla Christou, Henrik Westerberg, Amelia M Willett, Janine M Wotton, Willson B Roper, Audrey E Christiansen, Christopher S Ward, Jason D Heaney, Corey L Reynolds, Jan Prochazka, Lynette Bower, David Clary, Mohammed Selloum, Ghina Bou About, Olivia Wendling, Hugues Jacobs, Sophie Leblanc, Hamid Meziane, Tania Sorg, Enrique Audain, Arthur Gilly, Nigel W Rayner, Impc Consortium, Genomics England Research Consortium;, Marc-Phillip Hitz, Eleftheria Zeggini, Eckhard Wolf, Radislav Sedlacek, Steven A Murray, Karen L Svenson, Robert E Braun, Jaqueline K White, Lois Kelsey, Xiang Gao, Toshihiko Shiroishi, Ying Xu, Je Kyung Seong, Fabio Mammano, Glauco P Tocchini-Valentini, Arthur L Beaudet, Terrence F Meehan, Helen Parkinson, Damian Smedley, Ann-Marie Mallon, Sara E Wells, Harald Grallert, Wolfgang Wurst, Susan Marschall, Helmut Fuchs, Steve D M Brown, Ann M Flenniken, Lauryl M J Nutter, Colin Mckerlie, Yann Herault, K C Kent Lloyd, Mary E Dickinson, Valerie Gailus-Durner, Martin Hrabe De Angelis

Faculty, Staff and Students Publications

Clinical presentation of congenital heart disease is heterogeneous, making identification of the disease-causing genes and their genetic pathways and mechanisms of action challenging. By using in vivo electrocardiography, transthoracic echocardiography and microcomputed tomography imaging to screen 3,894 single-gene-null mouse lines for structural and functional cardiac abnormalities, here we identify 705 lines with cardiac arrhythmia, myocardial hypertrophy and/or ventricular dilation. Among these 705 genes, 486 have not been previously associated with cardiac dysfunction in humans, and some of them represent variants of unknown relevance (VUR). Mice with mutations in Casz1, Dnajc18, Pde4dip, Rnf38 or Tmem161b genes show developmental cardiac structural abnormalities, …

Interrogating The Nonincorporation Of The Grand Jury Clause, Roger Fairfax

Scholarly Articles in Law Reviews & Journals

With the Supreme Court's recent incorporation-in Ramos v. Louisiana of the Sixth Amendment's jury unanimity requirement to apply to the states, the project of "total incorporation" is all but complete in the criminal procedure context. Virtually every core criminal procedural protection in the Bill of Rights has been incorporated through the Due Process Clause of the Fourteenth Amendment to constrain not only the federal government but also the states with one exception. The Fifth Amendment's grand jury right now stands alone as the only federal criminal procedural right the Supreme Court has permitted states to ignore. In one of the …

Tracking Cryptic Sars-Cov-2 Lineages Detected In Nyc Wastewater, Davida S. Smyth, Monica Trujillo, Devon A. Gregory, Marc C. Johnson, John J. Dennehy, Et Al.

Biology Faculty Publications (Archived)

Tracking SARS-CoV-2 genetic diversity is strongly indicated because diversifying selection may lead to the emergence of novel variants resistant to naturally acquired or vaccine-induced immunity. To monitor New York City (NYC) for the presence of novel variants, we deep sequence most of the receptor binding domain coding sequence of the S protein of SARS-CoV-2 isolated from the New York City wastewater. Here we report detecting increasing frequencies of novel cryptic SARS-CoV-2 lineages not recognized in GISAID’s EpiCoV database. These lineages contain mutations that had been rarely observed in clinical samples, including Q493K, Q498Y, E484A, and T572N and share many mutations …

Coronavirus Disease 2019 (Covid-19) Research Agenda For Healthcare Epidemiology., Lona Mody, Ibukunoluwa C. Akinboyo, Hilary M. Babcock, Werner E. Bischoff, Vincent Chi-Chung Cheng, Kathleen Chiotos, Kimberly C. Claeys, K C Coffey, Daniel J. Diekema, Curtis J. Donskey, Katherine D. Ellingson, Heather M. Gilmartin, Shruti K. Gohil, Anthony D. Harris, Sara C. Keller, Eili Y. Klein, Sarah L. Krein, Jennie H. Kwon, Adam S. Lauring, Daniel J. Livorsi, Eric T. Lofgren, Katreena Merrill, Aaron M. Milstone, Elizabeth Monsees, Daniel J. Morgan, Luci P. Perri, Christopher D. Pfeiffer, Clare Rock, Sanjay Saint, Emily Sickbert-Bennett, Felicia Skelton, Katie J. Suda, Thomas R. Talbot, Valerie M. Vaughn, David J. Weber, Timothy L. Wiemken, Mohamed H. Yassin, Matthew J. Ziegler, Deverick J. Anderson, Shea Research Committee

Manuscripts, Articles, Book Chapters and Other Papers

This SHEA white paper identifies knowledge gaps and challenges in healthcare epidemiology research related to coronavirus disease 2019 (COVID-19) with a focus on core principles of healthcare epidemiology. These gaps, revealed during the worst phases of the COVID-19 pandemic, are described in 10 sections: epidemiology, outbreak investigation, surveillance, isolation precaution practices, personal protective equipment (PPE), environmental contamination and disinfection, drug and supply shortages, antimicrobial stewardship, healthcare personnel (HCP) occupational safety, and return to work policies. Each section highlights three critical healthcare epidemiology research questions with detailed description provided in supplementary materials. This research agenda calls for translational studies from laboratory-based …

Δnp63 Regulates A Common Landscape Of Enhancer Associated Genes In Non-Small Cell Lung Cancer, Marco Napoli, Sarah J Wu, Bethanie L Gore, Hussein A Abbas, Kyubum Lee, Rahul Checker, Shilpa Dhar, Kimal Rajapakshe, Aik Choon Tan, Min Gyu Lee, Cristian Coarfa, Elsa R Flores

Faculty, Staff and Students Publications

Distinct lung stem cells give rise to lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC). ΔNp63, the p53 family member and p63 isoform, guides the maturation of these stem cells through the regulation of their self-renewal and terminal differentiation; however, the underlying mechanistic role regulated by ∆Np63 in lung cancer development has remained elusive. By utilizing a ΔNp63-specific conditional knockout mouse model and xenograft models of LUAD and LUSC, we found that ∆Np63 promotes non-small cell lung cancer by maintaining the lung stem cells necessary for lung cancer cell initiation and progression in quiescence. ChIP-seq analysis of lung basal cells, …

Abnormal Perception Of Pattern-Induced Flicker Colors In Subjects With Glaucoma, Padmapriya Ramamoorthy, Nicole L Alexander, Benjamin J Frankfort

Faculty, Staff and Students Publications

Pattern-induced flicker colors (PIFCs) are subjective colors that can be elicited with rotation of an achromatic stimulus such as the Benham disk. The perceptive mechanisms underlying PIFCs are not well-understood, but are thought to be generated primarily by retinal cell types which may be dysfunctional in glaucoma. Using a custom computer-based system, we tested PIFC perception across several Benham disk parameters, including the rates of acceleration and deceleration, rotational direction, and image contrast in both control and glaucoma subjects. We defined the Benham perception limit (BPL) during acceleration as the rotational speed at which PIFCs were first detected (Benham perception …

Histone Post-Translational Modification Dysregulation Contributes To Toxicity In Amyotrophic Lateral Sclerosis Proteinopathy Models, Seth A. Bennett

Dissertations, Theses, and Capstone Projects

Amyotrophic Lateral Sclerosis (ALS) is the third most common adult onset neurodegenerative disorder worldwide. It is generally characterized by progressive paralysis starting at the limbs ultimately leading to death caused by respiratory failure. There is no cure and current treatments fail to slow the progression of the disease. As such, new treatment options are desperately needed. Epigenetic targets are an attractive possibility because they are reversible. Epigenetics refers to heritable changes in gene expression unrelated to changes in DNA sequence. Histone modifications, a main epigenetic mechanism, occur in many amino acid residues and include phosphorylation, acetylation, methylation as well as …

My Favorite Thing Is Monster Theory: Horror Comics And Demonstrating Difference In Emil Ferris’S "My Favorite Thing Is Monsters", Jennifer Rossberg

Dissertations, Theses, and Capstone Projects

My Favorite Thing is Monsters (2017) by Emil Ferris opens with the same etymological analysis of the word monster as Rosemarie Garland Thomson’s landmark disability studies article, “From Wonder to Error: A Discourse on Freak Genealogy” (1991). The protagonist of Ferris’s swirling, sketchbook-style thriller, Karen Reyes, is a mixed-race queer adolescent growing up in noirish 1960’s Chicago who longs to be a werewolf so she can bite and save her cancer-afflicted mother. After fleeing an imaginary, pitchfork-wielding M.O.B.—an acronym for “mean, ordinary, & boring” people—Karen explains that, “The dictionary says the word monster comes from the Latin word ‘monstrum’ which …

Reducing Fear Overgeneralization With Safety Learning: Attention Bias As A Moderator, Boyang Fan

Dissertations, Theses, and Capstone Projects

Anxiety disorders are the most prevalent mental health condition and affect one out of nine individuals around the world. Fear generalization is a neurocognitive mechanism thought to maintain and exacerbate anxiety, and thus is an important target of therapeutic interventions. Yet, intervention research and practice place relatively little emphasis on its importance. Given that a significant proportion of individuals do not respond to extant treatments of anxiety disorders, a strengthened focus on fear generalization may inform the development and personalization of new treatment approaches. Recent notions have linked fear generalization to failures in distinguishing between signals that predict the occurrence …

The Visionary Mode In Anglophone Modernist Fiction, Wei Wu

Dissertations, Theses, and Capstone Projects

This study is a critical reexamination of descriptions of visionary experiences in the novels of Woolf and Lawrence. Its goal is twofold: first, to demonstrate that the visionary mode, when best practiced by the modernist novelists here discussed, can overcome the ideological liabilities that its supposed individualist stance seems to entail; secondly, based on an updated understanding of the visionary mode, to reconceptualize its relation with the ordinary. Through discussions of five important modernist novels, this study concludes that modernist practicing of the visionary mode, when contextualized and historicized, portrays the subject as situated in dynamic exchanges with otherness, subscribes …

Staging The Ocean: The Emergence Of The Aquarium In Victorian England, Alaina Claire Feldman

Dissertations, Theses, and Capstone Projects

This thesis is a cultural history and analysis of the constructions and representations of nature through the apparatus of the saltwater aquarium, which I argue is historically embedded in forms of biocapitalist control that produce knowledge, difference and enclosure, and mediates a form of pedagogy used to extend empire into the ocean. I look to the origins of hobby and public aquariums in Victorian England to comprehend how imperial management of pristine environments gave rise to the aquariums that we know today. The marine aquarium examined here is a Western entity that reduces the world to dichotomies and oversimplifies vast …

A History Of The Center For The Study Of Women And Society, 1975–2015, Clarisa Gonzalez

Dissertations, Theses, and Capstone Projects

In the early 1970s, New York City was experiencing an extreme fiscal crisis, with a reported debt of at least $600 million. In CUNY, students were protesting admissions policies that favored the white middle class and hikes in tuition. At the same time, the women’s movement was in the midst of the “second wave,” focusing on women in the workplace and in education. It’s in the midst of these tumultuous times that the first motions to create what was then called the Center for the Study of Women and Sex Roles began in 1975 by Graduate Center faculty Joan Kelly, …

A Girl Is A Thing: Dramaturgies Of Objects And Nature In Contemporary Choreography, Fidan Akinci

Dissertations, Theses, and Capstone Projects

This dissertation investigates the expansion of performative possibilities toward and through nonhumans in contemporary choreography as a feminist inquiry. I research the upsurge of performing objects and natural matter in contemporary choreography by questioning what kind of bodies other than humans can move, and what kind of affects and expressions they offer beyond more familiar and anthropocentric possibilities. I link this challenge to the humanistic limits of performance with the feminist interrogations on agency and objectification to fully explore the political stakes of mobilizing with the nonhuman. To that end, I put the feminist trajectories in posthumanism, new materialism, and …

Investigation Of Behavioral Responses Including Visual Side Biases To Social Stimuli In Bottlenose Dolphins (Tursiops Truncatus), Jennifer R. Savoie

Dissertations, Theses, and Capstone Projects

Cetacean field studies have reported consistent population-level side biases for foraging behaviors and this right side feeding bias is arguably the strongest in any species next to handedness in humans. Notably, experimental studies with cetaceans, particularly dolphins, have struggled to find laterality in other behaviors, and some have reported patterns that are inconsistent with those typically found in vertebrates. Side biases related to social processing have been reported in a few observational studies of wild delphinids but have not been successfully evaluated in a controlled experimental context. This dissertation investigated viewing side biases of bottlenose dolphins in two contexts: when …

Past-Futures Of Harlem: Black Urban Space At The Limits Of Spatial Justice, Dane C. Ruffin

Dissertations, Theses, and Capstone Projects

The racial capitalist development of the U.S. metropolitan landscape has been shaped by the involuntary displacement and dispersal of Black communities. From the dispossession of the Half-Free Negro Lots around the Fresh Collect pond in the seventeenth century to the clearing of Seneca Village to build Central Park in the nineteenth century to the turn of the twentieth-century police-facilitated “race riot” in the Tenderloin district of Manhattan, which fueled the move to Harlem, the four-hundred year history of Black Manhattan alone provides substantial evidence of this and is in no way unique in this regard. Incomplete, yet ongoing, is what …

Air Pollution, Climate Change, And Our Health, Kathia Vargas Feliz

Dissertations, Theses, and Capstone Projects

Climate change is a subject that is creating a lot of controversies nowadays. From newspapers to researchers, there are big efforts going on trying to bring awareness about the effects of air pollution and climate change over time. It is recommended that governments all over the world, and people from all communities act by taking care of the environment because the situation might turn out to be irremediable. There is a quote by Leonardo Dicaprio stating, “Climate change is real. It is happening right now; it is the most urgent threat facing our entire species and we need to …

Control, Allegiance, And Shame In Male Qing Dynasty Hairstyles, Carolle Pinkerton

Dissertations, Theses, and Capstone Projects

This thesis is about the politicization of hairstyles in imperial China. They indicated conformity with social norms, or rebellion against them. This was especially true under the country’s last dynasty. The Manchu conquerors imposed their own hairstyle, the queue, on their Han Chinese subjects to make their rule palpable to China’s illiterate millions. “Hair martyrs” who refused to accept this “barbarous” hairstyle were ruthlessly eliminated. The Manchus had feared assimilation into the much larger Han population. But the introduction of one uniform male hair style for both Manchus and Han blurred the lines between the two groups. In this way …

Peru's Fishmeal Industry: Its Societal And Environmental Impact, Angel Vizurraga

Dissertations, Theses, and Capstone Projects

Peru is the biggest fishmeal-producing country in the world. It has exported millions of tons of fishmeal to various parts of the world since the 1960s. However, this industry has created many problems for the Peruvian people and their environment. Past research done on this topic has failed to include the negative impacts of the fishmeal industry. My project aims to exhibit the main issues that are affected or created by the fishmeal industry. I will talk about its impact on socioeconomic matters such as malnutrition and employment, as well as its impact on the environment and the wildlife population …

Mapping Flood Myths, Ashley Marie Rojas

Dissertations, Theses, and Capstone Projects

Water, as the source of all life, has the power to create and destroy. Floods, prior to modern meteorology, would have been seen as acts of the divine, leading to the creation of flood myths, stories, and legends from many civilizations. The power of water transcends time and connects all of humankind. Present day examples including hurricanes here in the US (Katrina, Maria, Irene to just name a few) and tsunamis like at Fukushima. Mapping Flood Myths will look at flood myths and legends from all over the world and plot the locations of these myths on web map with …

Historical Sisters: Black Feminist Actions Across History And Literary Studies, Jazz A. Milligan

Dissertations, Theses, and Capstone Projects

This thesis seeks to understand how the actions of Black women from the past have inspired the modern Black female literary movement. This thesis focuses on three historical women: Phillis Wheatley, Elizabeth Freeman, and Cathay Williams, and their literary sisters: bell hooks, Barbara Smith, and Patricia Hill Collins. By viewing the lives of these historical women through a modern-day lens, we can understand how their actions created a ripple effect that Black women are still discussing today. Black feminism did not start in a vacuum, and the actions of everyday Black women have pushed us forward to being more accepting …