Digital Commons Network^™

Activation Of Ras/Mapk Pathway Confers Mcl-1 Mediated Acquired Resistance To Bcl-2 Inhibitor Venetoclax In Acute Myeloid Leukemia, Qi Zhang, Bridget Riley-Gillis, Lina Han, Yannan Jia, Alessia Lodi, Haijiao Zhang, Saravanan Ganesan, Rongqing Pan, Sergej N Konoplev, Shannon R Sweeney, Jeremy A Ryan, Yulia Jitkova, Kenneth Dunner, Shaun E Grosskurth, Priyanka Vijay, Sujana Ghosh, Charles Lu, Wencai Ma, Stephen Kurtz, Vivian R Ruvolo, Helen Ma, Connie C Weng, Cassandra L Ramage, Natalia Baran, Ce Shi, Tianyu Cai, Richard Eric Davis, Venkata L Battula, Yingchang Mi, Jing Wang, Courtney D Dinardo, Michael Andreeff, Jeffery W Tyner, Aaron Schimmer, Anthony Letai, Rose Ann Padua, Carlos E Bueso-Ramos, Stefano Tiziani, Joel Leverson, Relja Popovic, Marina Konopleva

Faculty, Staff and Student Publications

Despite high initial response rates, acute myeloid leukemia (AML) treated with the BCL-2-selective inhibitor venetoclax (VEN) alone or in combinations commonly acquires resistance. We performed gene/protein expression, metabolomic and methylation analyses of isogenic AML cell lines sensitive or resistant to VEN, and identified the activation of RAS/MAPK pathway, leading to increased stability and higher levels of MCL-1 protein, as a major acquired mechanism of VEN resistance. MCL-1 sustained survival and maintained mitochondrial respiration in VEN-RE cells, which had impaired electron transport chain (ETC) complex II activity, and MCL-1 silencing or pharmacologic inhibition restored VEN sensitivity. In support of the importance …

Facial Recognition Technology: Issues, Legislation, And A Need For Education, Ivan Bohorquez

Cardozo International & Comparative Law Review (CICLR) Blog

Artificial Intelligence (“AI”) could be understood as information gathered through the use of technical machines that focus on cognition. At the micro-level, some examples of AI collecting devices include emotional detection tools, numberplate recognition devices, social network analysis devices, and – most known – Facial Recognition Technologies. Facial Recognition Technologies (“FRT”) compile and analyze human faces and are often used to build complex systems of identification and tracking. AI and FRT have been employed by various industries, including the advertising industry, the government, and the criminal legal system.

This post was originally published on the Cardozo International & Comparative Law …

#Golead Newsletter, Georgia Southern University

#GoLead Newsletter (2016-2023)

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Synthesis, Characterization, Photocatalysis, And Antibacterial Study Of Wo3, Mxene And Wo3/Mxene Nanocomposite, Al-Zoha Warsi, Fatima Aziz, Sonia Zulfiqar, Sajjad Haider

Faculty Journal Articles

Tungsten oxide (WO3), MXene, and an WO3/MXene nanocomposite were synthesized to study their photocatalytic and biological applications. Tungsten oxide was synthesized by an easy and cost-effective hydrothermal method, and its composite with MXene was prepared through the sonication method. The synthesized tungsten oxide, MXene, and its composite were characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), Fourier transform infrared (FTIR), energy-dispersive X-ray analysis (EDX), and Brunauer–Emmett–Teller (BET) for their structural, morphological, spectral, elemental and surface area analysis, respectively. The crystallite size of WO3 calculated from XRD was ~10 nm, the particle size of WO3 was 130 nm, …

Media Coverage, Attention Cycles And The Governance Of Plastics Pollution, Ian Bailey

School of Geography, Earth and Environmental Sciences

No abstract provided.

Covid-19 And Myocarditis: A Brief Review, Fatma Taher, Athar Eysa, Dalia Fahmy, Ahmed Shalaby, Ali Mahmoud, Moumen El-Melegy, Ahmed Abdel Khalek Abdel Razek, Ayman El-Baz

All Works

Cardiovascular complications (especially myocarditis) related to COVID-19 viral infection are not well understood, nor do they possess a well recognized diagnostic protocol as most of our information regarding this issue was derived from case reports. In this article we extract data from all published case reports in the second half of 2020 to summarize the theories of pathogenesis and explore the value of each diagnostic test including clinical, lab, ECG, ECHO, cardiac MRI and endomyocardial biopsy. These tests provide information that explain the mechanism of development of myocarditis that further paves the way for better management.

Eml1 Is Essential For Retinal Photoreceptor Migration And Survival, Deepak Poria, Chi Sun, Andrea Santeford, Michel Kielar, Rajendra S Apte, Oleg G Kisselev, Shimming Chen, Vladimir J Kefalov

Open Access Publications

Calcium regulates the response sensitivity, kinetics and adaptation in photoreceptors. In striped bass cones, this calcium feedback includes direct modulation of the transduction cyclic nucleotide-gated (CNG) channels by the calcium-binding protein CNG-modulin. However, the possible role of EML1, the mammalian homolog of CNG-modulin, in modulating phototransduction in mammalian photoreceptors has not been examined. Here, we used mice expressing mutant Eml1 to investigate its role in the development and function of mouse photoreceptors using immunostaining, in-vivo and ex-vivo retinal recordings, and single-cell suction recordings. We found that the mutation of Eml1 causes significant changes in the mouse retinal structure characterized by …

A Retrospective Investigation: Outcome Comparisons Between Septic Patients With And Without Secondary Diagnosis Of Hypothyroidism From A Rural Midwest Hospital, Anna Eshghi, Aaron S. Fanaee, Shelly N.B. Sloan, Greg Stahl, Kerry Johnson, Scott Goade, Robert Arnce

Faculty and Staff Publications

Background

Sepsis morbidity and mortality rates have remained high despite recent developments in clinical guidelines aimed to curtail this disease process. Understanding how sepsis interacts with comorbidities and pre-existing disease states is necessary for improving sepsis treatment. Accounting for specific pre-existing conditions in the treatment of sepsis patients may not only improve patient outcomes but also reduce healthcare costs by preventing possible complications. We sought to evaluate whether the presence of hypothyroidism affects outcomes in septic patients.

Methods

In this retrospective observational study, we analyzed the patient dataset from a not-for-profit rural hospital from January 2019 through June 2020. We …

The Influence Of Preoperative Dialysis On Survival After Continuous-Flow Left Ventricular Assist Device Implantation, Harveen K Lamba, Fadi I Musfee, Subhasis Chatterjee, Ajith P Nair, Andrew B Civitello, Leo Simpson, O H Frazier, George V Letsou

Faculty, Staff and Students Publications

OBJECTIVES: Dialysis is considered a contraindication to continuous-flow left ventricular assist device (CF-LVAD) implantation. We evaluated clinical outcomes and survival in carefully selected, low-risk patients with renal failure who required dialysis before CF-LVAD implantation.

METHODS: We extracted medical record data of patients who underwent CF-LVAD placement at our centre between 1 January 2006 and 31 August 2017, with 2 clinical scenarios: those who required long-term (>14 days) dialysis and those who required short-term (≤14 days) dialysis immediately before implantation. Demographic, clinical and intraoperative characteristics and survival outcomes were assessed.

RESULTS: Of 621 patients who underwent CF-LVAD implantation during the …

Epilepsy Mortality: Leading Causes Of Death, Co-Morbidities, Cardiovascular Risk And Prevention, Rohit Shankar, Christopher M. Degiorgio, Brian D. Moseley

Peninsula Medical School

Mortality rates in people with epilepsy are higher than expected, and epilepsy mortality rates in the United Kingdom, United States and the world are increasing. The causes for this increase in mortality rates are not well defined, however they may include increased reporting, increased prevalence, ineffective treatment of preventable risk factors, or ineffective prevention of epilepsy-specific mortality (e.g. SUDEP). The aim of this Research Topic is to provide a scholarly forum for original cutting edge research that addresses epilepsy mortality, epilepsy comorbidities, and interventions to reduce the risk of preventable death in people with epilepsy.

The Dance Of Ādi Śakti: The Goddess In The Songs Of Bharati And Nazrul, Achintya Prahlad

Yale Journal of Music & Religion

C Subramania Bharati (1882-1921) and Kazi Nazrul Islam (1899-1976) were significant poet-songwriters of the Indian freedom struggle. Their works explore a wide range of themes – political, philosophical, romantic and devotional. Both poets were educated in rāga music, which is prominent in many of their songs. Bharati wrote in Tamil, while Nazrul wrote in Bangla. It is highly unlikely that they read or were influenced by each other’s works. However, one finds several similarities in their poetry, especially the importance given to the goddess Ādi Śakti in her various forms, Kālī in particular. The goddess plays a major role in …

Bodies Of Silence, Floods Of Nectar: Ritual Music In Contemporary Brahmanical Tantric Temples Of Kerala, Paolo Pacciolla

Yale Journal of Music & Religion

The Tantric concept of sound (nāda) as universal life-force has seen worldwide diffusion over the last few decades but such a fame does not reflect academic interest in the impact of Tantra on music. Indeed, while a number of essays have been written to demonstrate the contribution of Tantrism to the evolution of Indian religions and culture, its contribution to music has been left largely unexplored.

The word Tantra refers to a pan-Asian religious phenomenon spread over numerous centuries and including a wide number of sects having different and even opposite philosophical and theological approaches which may be …

Liturgy And Musical Inculturation In A Post-Apartheid South African Catholicism, Austin Chinagorom Okigbo

Yale Journal of Music & Religion

There is a developing trend within mainstream South African Churches to incorporate styles of traditional African music and cultural elements in liturgical functions. This is happening in places where such ideas were hitherto unwelcome because mission churches witnessed the denigration of indigenous African cultures by Europeans during the eras of both colonialism and apartheid. Inculturation Theology underscores the current drive for liturgical transformation. It comprises a part of Black Theology in South Africa, which developed as an intellectual framework for liberation during the time of the anti-apartheid struggles. Using the ethnographic study of the cultural mass at Emmanuel Cathedral in …

A Scalable And Participatory Sustainable Rangeland Management Toolkit With A Holistic And Multidisciplinary Approach To Rehabilitate Degraded Rangelands, Mounir Louhaichi, Mouldi Gamoun, Sawsan Hassan

IGC Proceedings (1977-2023)

Rangelands contribute significantly toward improving livelihoods, offering food security, trade and tourism for pastoral communities. Numerous challenges include poor government policies, loss of indigenous knowledge and top-down approaches toward sustainable rangeland rehabilitation that often fail to consider local development adoption and sustainability. In such situations, effective management is needed for sustainable rangeland ecosystem goods and services in a context characterized by rainfall unreliability, poor soil nutrient status and high uncontrolled grazing. This paper presents a new comprehensive toolkit for identifying and combining suitable and site-specific interventions aimed at reversing the trend of degraded arid rangelands. This toolbox is founded on …

Pastoralist Use Of Reseeded Fields For Additional Resilience To Climate Variability Through Alternate Livelihood Activities, D. W. Githu, J. S. Fehmi, M. Mcclaran, M. Elizabeth, A. Josephson

IGC Proceedings (1977-2023)

Land degradation, climate variability, socio-economic changes and population increase are some of the factors that shrink grazing lands making forage availability less predictable and affecting the resilience of pastoralists communities. Reseeding as an intervention can rehabilitate degraded lands for profitable use through offering pastoralists alternative sources of livelihood and encourage livelihood diversification. This study evaluated two pastoral communities, the Tugen and the Njemps from Baringo County, Kenya, who have owned, managed and used reseeded fields to study the dynamics of reseeding land. A total of 193 pastoralist households were interviewed. These two pastoral communities used their fields for: dry season …

South Pacific, Big League Productions, Inc.

Broadway Tours

Program for the Broadway Tour production of South Pacific at the Bicknell Family Center for the Arts

How Much Margin Is Left For Degrading Agricultural Soils? The Coming Soil Crises, Maheteme Gebremedhin, Mark S. Coyne, Karamat R. Sistani

Plant and Soil Sciences Faculty Publications

Agricultural soils are in peril. Multiple lines of observational and empirical evidence suggest that we are losing the world’s fertile soils at an alarming rate, worsening the on-going global food crisis. It is increasingly clear that the risk of soil crises driven by erratic precipitation, warming air, and farming mismanagement is coming sooner rather than later. At this critical time, society cannot avoid looking for ways to curb soil crises. We argue that now is the right time for science-based mitigation strategies and new insights to protect soils. We offer four research priority areas that society needs to address. Arresting …

Scientific And Technological Reasons, Contents And Corresponding Policies Of Constructing “Coastal Grass Belt”, Weihua Xu, Jianlin Wang, Xiaojing Liu, Qi Xie, Weicai Yang, Xiaofeng Cao, Zhensheng Li

Bulletin of Chinese Academy of Sciences (Chinese Version)

Not only the grain rations must be secured absolutely in China, but also the feed grains. However, the limited arable land resource in China determines that grass planting shall not "compete for land with staple food". Planting high quality salt-tolerant forage grass on the saline wasteland and developing animal husbandry production can not only meet the demand of increasing proportion of animal protein in Chinese diet structure, but more importantly, it can help to solve the problems of insufficient forage planting and import over-dependence. Hence it plays an important role in guaranteeing national food security. Therefore, it is necessary to …

Book Reviews

Great Plains Sociologist

Reviewer: Karen Glumm
A Sociology of Mental Illness
Mark Tausig, Janet Michello, and Sree Subedi

Reviewer: Susan L. Schrader
Intersections: Readings in Sociology
Ralph B. McNeal, Jr., and Kathleen A. Tiemann, Eds.

Reviewer: Tracy B. Citeroni
White Saris and Sweet Mangoes: Aging, Gender, and Body in North India
Sarah Lamb

Reviewer: Michele Lee Chesser
Racist America: Roots, Current Realities, & Future Reparations
Joe R. Feagin

Reviewer: Annette Prosterman
Environmentalism Unbound: Exploring New Pathways for Change
Robert Gottlieb

Reviewer: Jack Niemonen
Tripping on the Color Line: Black-White Multiracial Families in a Racially Divided World
Heather M. Dalmage

Reviewer: Scott London
Colonizing …

Book Reviews

Great Plains Sociologist

Reviewer: Cynthia L. Phillips
Gender Justice in the American West: Women Prisoners in Men's Penitentiaries
Ann M. Butler

Reviewer: Mary Warner
New Pioneers in the Heartland: Hmong Life in Wisconsin
JoAnn Koltyk

Reviewer: Elizabeth A. Gill
Transgressing Borders: Critical Perspectives on Gender
Suzan Ilcan and Lynne Phillips, eds.

Reviewer: Melissa A. Jones
The Secret Life of Families: Truth-Telling, Privacy and Reconciliation in a Tell-All Society
Evan Imber-Black

Reviewer: Keith Crew
Murder Most Rare: The Female Serial Killer
Michael D. Kelleher and C.L. Kelleher

Reviewer: Jack Niemonen
New Tribalism: The Resurgence of Race and Ethnicity
Michael W. Hughey, ed.

Reviewer: Evandro …

A Vision For The Northern Great Plains, Dr. Cornelia Butler Flora

Great Plains Sociologist

This essay presents a number of positive alternatives for the future of the rural Northern Great Plains. A number of trends occurring in the 1990s are used to assemble this vision, such as sustainable agriculture, information technology, wireless communication, and small communities working together in mutual interest. This vision identifies the important role of social capital and social relationships as rising in value over a consumer oriented society. The strength of a positive vision exists in its ability to fire people to actively seek these ends, [ed.]

Three Theories Of The Future Of The Great Plains, Scot A. Stradley

Great Plains Sociologist

The purpose of this paper is to present three theories of the future of the Great Plains. The theories consist of two extremes, based on the differences between supply and demand. Two of the three theories of the future of the Great Plains are supply side. One is a demand side theory. One or more of these theories can be found in public policy debates affecting the Plains.

The Not So Wonderful World Of Disney: An Exploratory Content Analysis Of Gender Themes In Disney Full Length Animated Feature Films, Beth Wiersma

Great Plains Sociologist

Research has focused on the gender messages portrayed in television programs, cartoons, advertisements, literature, picture books, and fairy tales. One venue not included in the research is the Disney full-length animated feature films. The initial research on which this article is based was an exploration of the themes of gender, violence and anthropomorphism in Disney films. Emergent themes include heterosexual couplings, family constellations, good versus evil, and villains. This article will cover only the gender themes. Five areas were used to code gender content which include: physical appearance, personality traits, in-home labor, out of home employment, and societal and familial …

Front Matter

Great Plains Sociologist

Front Matter
Editorial Policy Statement
Contents

The Importance Of College Student Academic Goals: A Symbolic Interactionist Approach, Donald E. Arwood, Donna J. Hess

Great Plains Sociologist

A cross-sectional study of a sample of first and second year students attending a moderately-sized, Great Plains university is used to demonstrate the correlation between academic self-conceptions and academic goals. Multiple regression analysis shows that academic self-conceptions, academic role-taking, job goals, being a parent, and having a Job are excellent predictors of academic goals. The authors recommend that the symbolic interactionist perspective used in the study should be used to study how academic goals link academic self-conceptions with academic behaviors and outcomes.

Book Reviews

Great Plains Sociologist

Diane Kayongo-Male, reviewer
People, Land, and Community
Hildegarde Hannum

Elizabeth Evenson Williams, reviewer
Contested Countryside Cultures: Otherness, Marginalisation, and Rurality
Paul Cloke and Jo Little, editors

Janet Kelly Moen, reviewer
Changing Rural Social Systems: Adaptation and Survival
Nan E. Johnson and Ching-li Wang, editors

Carol J. Cumber, reviewer
Rural Employment: An International Perspective
Ray D. Bollman and John M. Bryden, editors

Laura Colmenero, reviewer
Writing the Range: Race, Class, and Culture in the Women's West
Elizabeth Jameson and Susan Armitage, editors

William J. Swart, reviewer
Harvest of Rage: Why Oklahoma City is Only the Beginning
Joel Dyer

Ellen Baird, reviewer …

Book Reviews

Great Plains Sociologist

Diane Kayongo-Male, reviewer
Gendered Fields: Rural Women, Agriculture, and Environment
Carolyn Sachs

Henry B. Sirgo, reviewer
Green Culture: Environmental Rhetoric in Contemporary America
Carl G. Herndl and Stuart C. Brown

Janet Kelly Moen, reviewer
New Government for Rural America: Creating Intergovernmental Partnerships
Beryl A. Radin, Robert Aganoff, Ann O'M Bowman, C. Gregory Buntz, Steven Ott, Barbara S. Romzek, and Robert H. Wilson

Jon Flanagin, reviewer
Wanted Dead or Alive: The American Westin Popular Culture
Richard Aquila, editor

Laura Colmenero, reviewer
Contented Among Strangers: Rural German-Speaking Women and Their Families in the Nineteenth-Century Midwest
Linda Schelbitzki Pickle

Elizabeth Evenson Williams, reviewer …

Ethnic Minorities In The People's Republic Of China, Mary Jo Benton Lee

Great Plains Sociologist

In the People's Republic of China, the term "minority nationality" denotes a member of one of China's 55 officially recognized ethnic minority groups. Minority nationalities have traditionally been regarded as those who have cultures (particularly languages and religions) that atv distinct from the Han Chine.ie majority. This article focuses on ethnic minorities in China-their significance to the PRC as a whole, the official classification system by which the government identifies them and the history of their interaction with the majority Han population. Higher education in the PRC is discussed with an emphasis on national minority institutes. Two macro issues relating …

Jackie Mcdonald, Wilmer Amina Carter Foundation

Bridges Digital Archive: Audio and Video Recordings

In this interview, Jackie McDonald is the guest. She starts the interview by explaining that her family moved to Riverside County after seeing a friend with acres of land. Since she and her husband wanted their son to have a life outside of the city, and because her husband wanted to be a farmer, they felt that it was necessary. When she arrived, she saw that the younger generations had no respect for the older folk which she was taught. Seeing this as a problem she wanted to help with, she created an etiquette and modeling class through the Perris …

Arelene Wilson Jackson, Wilmer Amina Carter Foundation

Bridges Digital Archive: Audio and Video Recordings

In this interview, Arlene Wilson Jackson is the guest. She is asked about how her family had arrived in Riverside County, particularly her great-grandparents moving to Perris. Wilson Jackson remembers cooking with her great-grandmother and has a recipe from her that she still uses to this day. She mentions having wonderful memories of her family, such as spending summers in Perris and just doing family activities. Apart from being in social organizations such as Veterans Without a Family, The Lions Club, and the Rotary Club, Wilson Jackson created her nonprofit, Restoring Hope Community Services, in Perris. This organization provides resources …