Digital Commons Network^™

C1q/Tnf-Related Protein 3 Prevents Diabetic Retinopathy Via Ampk-Dependent Stabilization Of Blood–Retinal Barrier Tight Junctions, Zheyi Yan, Chunfang Wang, Zhijun Meng, Lu Gan, Rui Guo, Jing Liu, Wayne Bond Lau, Dina Xie, Jianli Zhao, Bernard Lopez, Theodore Christopher, Ulhas P. Naik, Xin-Liang Ma, Yajing Wang

Department of Medicine Faculty Papers

Background The impairment of the inner blood–retinal barrier (iBRB) increases the pathological development of diabetic retinopathy (DR), a severe complication in diabetic patients. Identifying approaches to preserving iBRB integrity and function is a significant challenge in DR. C1q/tumor necrosis factor-related protein-3 (CTRP3) is a newly discovered adipokine and a vital biomarker, predicting DR severity. We sought to determine whether and how CTRP3 affects the pathological development of non-proliferative diabetic retinopathy (NPDR). Methods To clarify the pathophysiologic progress of the blood–retinal barrier in NPDR and explore its potential mechanism, a mouse Type 2 diabetic model of diabetic retinopathy was used. The …

Taxonomic And Phylogenetic Diversity Of Pitcher Plant Bogs In Georgia's Coastal Plain, Melanie Flood

Theses and Dissertations

Diversity studies via floristic survey and taxonomic metrics have proven essential for discerning community composition and biodiversity, however, phylogenetic analyses are necessary to reveal underlying evolutionary change and potential community assembly patterns. Pitcher plant bogs are highly diverse, highly understudied habitats that contain numerous listed and at-risk plant and animal species of Georgia.

In this study I investigated the taxonomic and phylogenetic diversity of pitcher plant bogs by asking the following questions:

1) What is the taxonomic diversity of pitcher plant bogs,

2) What is the dispersion of phylogenetic diversity within bog habitats, and

3) Does taxonomic and phylogenetic diversity …

Identifying Molecular Markers For Early Detection Of Toxic Cyanobacteria And Dinoflagellate, Shafqat F. Ehsan

Honors Program Theses and Research Projects

Harmful algal Blooms (HABs) develop when algal colonies grow out of control, causing toxicity or injury to humans, fish, shellfish, marine mammals, and birds. Most HABs of public health concern in saltwater generally are caused by eukaryotic dinoflagellates and diatoms. Prokaryotic cyanobacteria are usually responsible for freshwater blooms although they can contribute to saltwater and brackish blooms too. A common monitoring target of both groups is the saxitoxin-encoding genes. Saxitoxin(STX) is responsible for Paralytic shellfish poisoning, a foodborne illness developed from consumption of STX contaminated shellfish. Each cyanobacterial SXT gene cluster contains a set of core genes, common to all …

Stat6 Blockade Abrogates Aspergillus-Induced Eosinophilic Chronic Rhinosinusitis And Asthma, A Model Of Unified Airway Disease, Hua Sun, Ashish Damania, Megan L Mair, Eniola Otukoya, Yi-Dong Li, Katherine Polsky, Yuying Zeng, Jeremiah A Alt, Martin J Citardi, David B Corry, Amber U Luong, John Morgan Knight

Faculty, Staff and Student Publications

Unified airway disease, including concurrent asthma and chronic rhinosinusitis (CRS), is a common, but poorly understood disorder with no curative treatment options. To establish a murine model of chronic unified eosinophilic airway inflammation, mice were challenged with Aspergillus niger, and sinonasal mucosa and lung tissue were evaluated by immunohistochemistry, flow cytometry, and gene expression. Inhalation of A niger conidia resulted in a Th2-biased lung and sinus inflammation that typifies allergic asthma and CRS. Gene network and pathway analysis correlated with human disease with upregulation of not only the JAK-STAT and helper T-cell pathways, but also less expected pathways governing …

Bfs News Online, Georgia Southern University

Art: News & Publications (2008-2023)

• Georgia Southern University Senior Show Features Skills and Stories

Newsroom, Georgia Southern University

Newsroom (2006-2023)

• Georgia Southern University Seniors Show Features Skills and Stories
• Waters College of Health Professions Establishes Advisory Board
• National Youth Conference Returns to In-Person March 6-9
• Georgia Southern Recognition from Arbor Day Foundation

Marginality In Inquiry-Based Science Learning Contexts: The Role Of Exclusion Cascades, Karlyn Adams-Wiggins, Julia Sara Dancis

Psychology Faculty Publications and Presentations

Vygotskyan-inspired theories of learning have been applied in science education research, yet to more explicit attention to links between local social interactions and cultural-historical processes is needed advance critical theories of science learning. This microgenetic case study examined identity and motivation processes in a 7th grade inquiry science context with the goal of better historicizing these processes by describing the phenomenon of exclusion cascades in relation to two backgrounded cultural-historical processes, alienation and the social division of labor. Exclusion cascades highlighted the mutual constitution of competence and belonging. Implications are discussed with respect to challenging adaptationist ethos in science education.

The Parthenon, February 23, 2022, Tyler Spence, Connor Woodruff, Tyler Kennett, Evan Green, Shauntelle Thompson, Rafael Alfonso, Abby Hanlon, Abby Ayes, Alaina Laster, Isabella Robinson

The Parthenon

No abstract provided.

Volume Xvi, 1989 Speech Association Of Minnesota Journal

Communication and Theater Association of Minnesota Journal

Complete digitized volume (volume 16, 1989) of Speech Association of Minnesota Journal.

Tempering Our Expectations: Drinking, Smoking, And The Economy Of A Western Massachusetts Farmstead-Tavern, Laura E. Masur, Aaron F. Miller

Northeast Historical Archaeology

Between 1800 and 1830, William Sanford and his family operated a tavern in Hawley, a hilltown in western Massachusetts. The establishment was located on the town’s common, adjacent to the community’s Congregational meetinghouse and several other taverns. At the initiative of the local historical preservation group the Sons and Daughters of Hawley, archaeologists, students, teachers, and community members excavated the tavern site between 2011 and 2014. Historical and archaeological research indicates that William Sanford’s homestead functioned not only as a tavern, but also as a farm, store, smithy, and occasionally a court of law. Material evidence of alcohol and tobacco …

"A Quixote In Imagination Might Here Find...An Ideal Baronage": Landscapes Of Power, Enslavement, Resistance, And Freedom At Sherwood Forest Plantation, Lauren K. Mcmillan

Northeast Historical Archaeology

In the winter of 1862, two armed forces descended upon Fredericksburg; one blue, one gray. After suffering heavy losses during the Battle of Fredericksburg, the Union Army retreated to the northern banks of the Rappahannock River, making camp in Stafford County. From December 1862 until June 1863, the Union Army overran local plantations and small farm holdings throughout the area, including at Sherwood Forest, the home of the Fitzhugh family. Sherwood Forest was used as field hospital, a signal station, a balloon launch reconnaissance station, and a general encampment during the winter and spring of 1862/1863. Throughout the roughly six-month …

“Take An Ounce Of Suffolk Cheese”: Home Repair Of Eighteenth Century Ceramics At Ferry Farm, George Washington’S Boyhood Home, Mara Z. Kaktins, Melanie Marquis, Ruth Ann Armitage, Daniel Fraser

Northeast Historical Archaeology

The archaeological discovery at Ferry Farm of eighteenth century glue residues on tea and tablewares belonging to George Washington’s mother, Mary, raised a number of questions. Although recent research in the archaeological and decorative arts community on repaired ceramic and glasswares was helpful to some extent it primarily focused on professional repairs. At-home mending remained a mystery. Archaeologists at Ferry Farm responded by conducting extensive experimental archaeology on historic glues, replicating period glue recipes to determine the properties of these historic adhesives. Additionally, residue samples of suspected glue were analyzed by chemists from Eastern Michigan and Lourdes Universities utilizing Direct …

Volume Xii, 1985 Speech Association Of Minnesota Journal

Communication and Theater Association of Minnesota Journal

Complete digitized volume (volume 12, 1985) of Speech Association of Minnesota Journal.

Volume Xi, 1984 Speech Association Of Minnesota Journal

Communication and Theater Association of Minnesota Journal

Complete digitized volume (volume 11, 1984) of Speech Association of Minnesota Journal.

Volume Ix, 1982 Speech Association Of Minnesota Journal

Communication and Theater Association of Minnesota Journal

Complete digitized volume (volume 9, 1982) of Speech Association of Minnesota Journal.

Volume V, 1978 Speech Association Of Minnesota Journal

Communication and Theater Association of Minnesota Journal

Complete digitized volume (volume 5, 1978) of Speech Association of Minnesota Journal.

Modeling Of Liver Fibrosis In Small Laboratory Animals, Feruza Kh. Inoyatova, Maksud S. Khayitov, Rajab I. Isroilov

Central Asian Journal of Medicine

Chronic toxic liver damage resulting in cirrhosis was caused by intraperitoneal administration of a 30% solution of CCl 4 in olive oil at a dose of 1 ml/kg of body weight 2 times a week for 30 days, followed by the introduction of a 50% solution in olive oil at a rate of 1 ml/kg. kg into the abdominal cavity for up to 50 days. To potentiate the hepatotoxic effect of CCl4 , the animals received orally 5 ml of 5% ethanol solution once a day, starting from the 3rd day of the experiment. The duration of the experiment was …

Analysis Of The Epizootic Situation On The Territory Of The Central Section Of The Kyzylkum Natural Plague Focus At The Present Stage, A.N. Dmitriev, A.S. Nematov, J.A. Rakhmanova

Central Asian Journal of Medicine

Epizootological examination was carried out on the areas of the Central section of the Kyzylkum plague outbreak around the NMMC facilities. The phenomenon of depression of the number of the main plague carrier was noted, against the background of a period of gradual warming, which explains the absence of spilled plague epizootics. The existing epidemiological prerequisites provide real grounds for increasing the risks of epidemiological complications and requires constant monitoring of the state of epizootic activity in the Central Kyzylkum territory.

Salmon Week Four Clean Transcript, Paulo Santesso Goncalves

Heritage Conversation Partners

No abstract provided.

What Knowledge Do Early Childhood Teachers Use During Literacy Instruction? Using Stimulated Recall To Investigate An Unexplored Phenomenon, Rachel E. Schachter

Department of Child, Youth, and Family Studies: Faculty Publications

This study utilized a novel phenomenological approach with a stimulated recall procedure to understand the pedagogical reasoning of eight early child teachers during the enactment of literacy instruction in whole-group meeting and language arts activities. This approach to investigating knowledge—in contrast to more tra­ditional conceptualizations of knowledge—focused on knowledge use as a process and prioritized teachers’ perspectives on knowledge used to enact literacy instruc­tion in their own classrooms. Additionally, it allowed for a more nuanced investi­gation of the role of setting and teacher characteristics that are often examined in association with literacy instruction (e.g., degree attainment, years of experience, curriculum, …

Spartan Daily, February 22, 2022, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2022

Volume 158, Issue 11

Brief Of Amici Curiae Eparchy Of Our Lady Of Lebanon Of Los Angeles And The Orthodox Church In America In Support Of Appellee's Petition To Transfer, John A. Meiser

Court Briefs

No. 22S-CP-302
Payne-Elliott v. Roman Catholic Archdiocese of Indianapolis, Inc.

Court of Appeals Case No. 21A-CP-00936

Appeal from the Marion Superior Court 1

Trial Court Case No. 49D01-1907-PL-027728

The Honorable Lance Hamner, Special Judge

From the Summary of Argument

This case challenges a decision that is manifestly ecclesiastical: a directive from the Archbishop of Indianapolis regarding what policies a religious school must follow in order to be faithfully Catholic and to remain formally part of his Archdiocese. That is a question of exclusively religious concern. In the religious traditions of the Archdiocese and amici, it is a question which …

Bacterial Indole As A Multifunctional Regulator Of Klebsiella Oxytoca Complex Enterotoxicity, Nagender Ledala, Mishika Malik, Karim Rezaul, Sara Paveglio, Anthony Provatas, Aaron Kiel, Melissa Caimano, Yanjiao Zhou, Jonathan Lindgren, Kristyna Krasulova, Peter Illes, Zdenek Dvorak, Sandhya Kortagere, Sabine Kienesberger, Amar Cosic, Lisa Pöltl, Ellen L. Zechner, Subho Ghosh, Sridhar Mani, Justin D. Radolf, Adam P. Matson

Faculty Research 2022

Gastrointestinal microbes respond to biochemical metabolites that coordinate their behaviors. Here, we demonstrate that bacterial indole functions as a multifactorial mitigator of Klebsiella grimontii and Klebsiella oxytoca pathogenicity. These closely related microbes produce the enterotoxins tilimycin and tilivalline; cytotoxin-producing strains are the causative agent of antibiotic-associated hemorrhagic colitis and have been associated with necrotizing enterocolitis of premature infants. We demonstrate that carbohydrates induce cytotoxin synthesis while concurrently repressing indole biosynthesis. Conversely, indole represses cytotoxin production. In both cases, the alterations stemmed from differential transcription of npsA and npsB, key genes involved in tilimycin biosynthesis. Indole also enhances conversion of tilimycin …

Paradigm Versus Paradox On The Prairie: Testing Competing Stream Fish Movement Frameworks Using An Imperiled Great Plains Minnow, Zachary D. Steffensmeier, Maeghen Wedgeworth, Lauren Yancy, Noah Santee, Shannon K. Brewer, Joshuah S. Perkin

United States Geological Survey: Staff Publications

Background: Movement information can improve conservation of imperiled species, yet movement is not quantified for many organisms in need of conservation. Prairie chub (Macrhybopsis australis) is a regionally endemic freshwater fish with unquantified movement ecology and currently considered for listing under the Endangered Species Act. The purpose of this study was to test competing ecological theories for prairie chub movement, including the colonization cycle hypothesis (CCH) that posits adults must make upstream movements to compensate for downstream drift at early life stages, and the restricted movement paradigm (RMP) that describes populations as heterogeneous mixes of mostly stationary …

Washington Dairy Survey 2020, Jennifer E. Givens, Michael D. Briscoe

Browse all Datasets

These data are part of the dissertation research of Michael D. Briscoe. This research analyzed the association between modernization and farmer alienation from their work and their cows, as well as their overall life satisfaction. The results show that modernization has mixed effects on farmer alienation. This statistical finding was supported by interviews with farmers, who expressed that large farms can make it hard to maintain a relationship with their cows, but that technology actually replaces negative aspects of this relationship and allows for new forms of interaction.

Ghost Mitochondria Drive Metastasis Through Adaptive Gcn2/Akt Therapeutic Vulnerability, Jagadish C Ghosh, Michela Perego, Ekta Agarwal, Irene Bertolini, Yuan Wang, Aaron R Goldman, Hsin-Yao Tang, Andrew V Kossenkov, Catherine J Libby, Lucia R Languino, Edward F Plow, Annamaria Morotti, Luisa Ottobrini, Marco Locatelli, David W Speicher, M Cecilia Caino, Joel Cassel, Joseph M Salvino, Marie E Robert, Valentina Vaira, Dario C Altieri

Department of Cancer Biology Faculty Papers

Cancer metabolism, including in mitochondria, is a disease hallmark and therapeutic target, but its regulation is poorly understood. Here, we show that many human tumors have heterogeneous and often reduced levels of Mic60, or Mitofilin, an essential scaffold of mitochondrial structure. Despite a catastrophic collapse of mitochondrial integrity, loss of bioenergetics, and oxidative damage, tumors with Mic60 depletion slow down cell proliferation, evade cell death, and activate a nuclear gene expression program of innate immunity and cytokine/chemokine signaling. In turn, this induces epithelial-mesenchymal transition (EMT), activates tumor cell movements through exaggerated mitochondrial dynamics, and promotes metastatic dissemination in vivo. In …

The Europdx Data Portal: An Open Platform For Patient-Derived Cancer Xenograft Data Sharing And Visualization., Zdenka Dudová, Nathalie Conte, Jeremy Mason, Dalibor Stuchlík, Radim Peša, Csaba Halmagyi, Zinaida Perova, Abayomi Mosaku, Ross Thorne, Alex Follette, Ľuboslav Pivarč, Radim Šašinka, Muhammad Usman, Steven Neuhauser, Dale A. Begley, Debra M Krupke, Massimiliano Frassà, Alessandro Fiori, Riccardo Corsi, Luca Vezzadini, Claudio Isella, Andrea Bertotti, Carol J Bult, Helen Parkinson, Enzo Medico, Terrence Meehan, Aleš Křenek

Faculty Research 2022

BACKGROUND: Patient-derived xenografts (PDX) mice models play an important role in preclinical trials and personalized medicine. Sharing data on the models is highly valuable for numerous reasons - ethical, economical, research cross validation etc. The EurOPDX Consortium was established 8 years ago to share such information and avoid duplicating efforts in developing new PDX mice models and unify approaches to support preclinical research. EurOPDX Data Portal is the unified data sharing platform adopted by the Consortium.

MAIN BODY: In this paper we describe the main features of the EurOPDX Data Portal ( https://dataportal.europdx.eu/ ), its architecture and possible utilization by …

Priests Of A Fallen Creation: The Temple, Natural Theology, And Ecology In Dialogue, Eric Long

Speakers & Events

As we try to make sense of both creation’s goodness and decay, Dr. Long proposes that a fruitful path forward involves synthesizing recent advances in the three fields: natural sciences (with an emphasis on ecology), natural theology (with an emphasis on Christian natural theology), and Biblical theology (with an emphasis on reading creation as God’s earthly temple). In the lecture, Dr. Long will first develop this three-pronged, interdisciplinary approach. Then, he will demonstrate how this approach may prove fruitful in addressing five, roughly chronological, questions ranging from creation to eschatology:

• Why does creation exist?
• How can we interpret the “goodness” …

“Incorrigibility Is Inconsistent With Youth”: The Supreme Court’S Missed Opportunity To Cure The Contradiction Implicit In Discretionary Jlwop Sentencing, Ana Ionescu

University of Miami Law Review

The juvenile life without parole (“JLWOP”) caselaw is based in part on the science underlying adolescent brain development. Numerous research studies have examined the behaviors and brain processes of adolescents. Courts have relied on these findings in reaching some of its most important decisions affecting juveniles implicated in the criminal justice system. The latest of those decisions came in 2021 with the Jones v. Mississippi case before the United States Supreme Court. The Court held that a sentencing court is not required to make a specific finding of permanent incorrigibility before sentencing the juvenile defendant to life without parole. This …

Neural Correlates Of Inhibitory Control And Associations With Cognitive Outcomes In Bangladeshi Children Exposed To Early Adversities, Eileen F. Sullivan, Wanze Xie, Stefania Conte, John E. Richards, Talat Shama, Rashidul Haque, William A. Petri, Charles A. Nelson

Faculty Publications

There is strong support for the view that children growing up in low-income homes typically evince poorer performance on tests of inhibitory control compared to those growing up in higher income homes. Unfortunately, the vast majority of the work documenting this association has been conducted in high-income countries. It is not yet known whether the mechanisms found to mediate this association would generalize to children in low- and middle-income countries, where the risks of exposure to extreme poverty and a wide range of both biological and psychosocial hazards may be greater. We examined relations among early adversity, neural correlates of …