Digital Commons Network^™

The Effects Of The Global Covid-19 Pandemic On Pastors In The Church Of The Nazarene, Beth Bleadingheiser Heath

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to describe the experience of living through and ministering during the global COVID-19 pandemic for Nazarene pastors in Ohio. The theoretical framework that guided the research was Hope Theory and Resilience. The Conceptual Mapping Task was used to conduct interviews of eight ordained Nazarene pastors. Pastors described their experience and then worked with a researcher to create a concept map to organize their story. Pastors were asked to describe their story of living through and ministering during the global COVID-19 pandemic. Pastors were also asked how the global COVID-19 pandemic affected their church …

Dmp1 Lineage Cells Contribute Significantly To Periosteal Lamellar Bone Formation Induced By Mechanical Loading But Are Depleted From The Bone Surface During Rapid Bone Formation, Taylor L Harris, Matthew J Silva

2020-Current year OA Pubs

Previous work has shown that osteoprogenitor cells (Prx1+) and pre-osteoblasts (Osx+) contribute to mechanical loading-induced bone formation. However, the role of mature Dmp1-expressing osteoblasts has not been reported. In this study we assessed the contribution of osteoblast lineage cells to bone formation at an early time point following mechanical loading (day 8 from onset of loading). We labeled Osx-expressing and Dmp1-expressing cells in inducible Osx and Dmp1 reporter mice (iOsx-Ai9, iDmp1-Ai9), respectively, 3 weeks before loading. Mice were then loaded daily for 5 days (days 1-5) and were dosed with 5-ethynyl-2'-deoxyuridine (EdU) in their drinking water until euthanasia on day …

A Tail Of Plumage Colouration: Disentangling Geographic, Seasonal And Dietary Effects On Plumage Colour In A Migratory Songbird, Sean M. Mahoney, Matthew W. Reudink, Andrea Contina, Kelly A. Roberts, Veronica T. Schabert, Emily G. Gunther, Kristen M. Covino

School of Integrative Biological & Chemical Sciences Faculty Publications

Plumage ornamentation in birds serves critical inter- and intra-sexual signaling functions. While carotenoid-based plumage colouration is often viewed as a classic condition-dependent sexually selected trait, plumage colouration can be influenced by a wide array of both intrinsic and extrinsic factors. Understanding the mechanisms underlying variation in colouration is especially important for species where the signaling function of ornamental traits is complex or when the literature is conflicting. Here, we examined variation in the yellow/orange tail feathers of American redstarts Setophaga ruticilla passing through two migratory stopover sites in eastern North America during both spring and fall migration to assess the …

Insecticide Resistance In Aedes Aegypti Varies Seasonally And Geographically In Texas/Mexico Border Cities, Heather Hernandez, Flor A. Martinez, Christopher Vitek

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Insecticide use is the primary method of attempting to reduce or control the spread of mosquito-borne diseases. Insecticide resistance is a major concern as resistance will limit the efficacy of vector-control efforts. The lower Rio Grande Valley region of South Texas has had autochthonous transmission of multiple mosquito-borne diseases including those caused by dengue virus, chikungunya virus, and Zika virus. However, the current status of mosquito resistance to commonly used pesticides in this region is unknown. In this study, we collected field samples from multiple municipalities in South Texas and assessed resistance using the Centers for Disease Control and Prevention …

Untargeted Metabolomic Identification Of Diagnostic Biomarkers In Ectopic Pregnancy, Onur Turkoglu, Robert Quinn, Stewart F. Graham, Ray Bahado-Singh

Conference Presentation Abstracts

Introduction: Ectopic pregnancy (EP) is a potentially life-threatening condition and early diagnosis still remains a challenge, causing a delay in management leading to tubal rupture. Targeted metabolomics has been shown to identify novel biomarkers for the detection of ectopic pregnancy. Using untargeted metabolomics approach, we sought to identify putative plasma biomarkers for the detection of tubal EP compared to intrauterine pregnancies. Methods: This case-control study included prospective recruitment of 50 tubal EP cases and 50 early intrauterine pregnancy controls. Plasma samples were biochemically profiled using tandem liquid chromatographymass (MS/MS) spectrometry with untargeted metabolomics approach. To avoid over-fitting, datasets were randomly …

A Scoping Review Of The Experiences Of Adolescents And Young Adults In The Icu, Their Family Members, And Their Health Care Team, Natalie S. Mcandrew, Jeanne Erickson, Jill L. Guttormson, Alexandrea Bear, Sean Marks, Jayshil Patel, Eric Harding

College of Nursing Faculty Research and Publications

No abstract provided.

Chans-Law: Preventing The Next Pandemic Through The Integration Of Social And Environmental Law, Kirsten Davies, Michelle Mei Ling Lim, Tianbao Qin, Philip Riordan

Research Collection Yong Pung How School Of Law

Zoonotic viruses have sacrificed hundreds of millions of people throughout human history. There are currently 1.7 million unidentified viruses estimated to be circulating in mammal and bird populations. It is foreseeable that in the near future, another of these will transmit to people, heralding the start of the next pandemic—one potentially more deadly than COVID-19. At the core of this article is a call for pre-emptive protection of the natural environment and its regenerative systems as the first fundamental step in the prevention of future epidemics and pandemics. While zoonoses originate in nature, the predominant legal discipline, managing these crises, …

The Degenerative Impact Of Hyperglycemia On The Structure And Mechanics Of Developing Murine Intervertebral Discs, Marianne Lintz, Remy E Walk, Simon Y Tang, Lawrence J Bonassar

2020-Current year OA Pubs

INTRODUCTION: Diabetes has long been implicated as a major risk factor for intervertebral disc (IVD) degeneration, interfering with molecular signaling and matrix biochemistry, which ultimately aggravates the progression of the disease. Glucose content has been previously shown to influence structural and compositional changes in engineered discs in vitro, impeding fiber formation and mechanical stability.

METHODS: In this study, we investigated the impact of diabetic hyperglycemia on young IVDs by assessing biochemical composition, collagen fiber architecture, and mechanical behavior of discs harvested from 3- to 4-month-old db/db mouse caudal spines.

RESULTS: We found that discs taken from diabetic mice with elevated …

Reproducible Brain-Wide Association Studies Require Thousands Of Individuals, Scott Marek, David F Montez, Benjamin P Kay, Alexander S Hatoum, Meghan Rose Donohue, Ryland L Miller, Sridhar Kandala, Dillan J Newbold, Annie Zheng, Nicole A Seider, Andrew N Van, Athanasia Metoki, Timothy O Laumann, Steven E Petersen, Deanna M Barch, Nico U F Dosenbach, Et Al.

2020-Current year OA Pubs

Magnetic resonance imaging (MRI) has transformed our understanding of the human brain through well-replicated mapping of abilities to specific structures (for example, lesion studies) and functions

Design, Usability, And Acceptability Of A Needs-Based, Automated Dashboard To Provide Individualized Patient-Care Data To Pediatric Residents, Julia K W Yarahuan, Huay-Ying Lo, Lanessa Bass, Jeff Wright, Lauren M Hess

Faculty, Staff and Students Publications

BACKGROUND AND OBJECTIVES: Pediatric residency programs are required by the Accreditation Council for Graduate Medical Education to provide residents with patient-care and quality metrics to facilitate self-identification of knowledge gaps to prioritize improvement efforts. Trainees are interested in receiving this data, but this is a largely unmet need. Our objectives were to (1) design and implement an automated dashboard providing individualized data to residents, and (2) examine the usability and acceptability of the dashboard among pediatric residents.

METHODS: We developed a dashboard containing individualized patient-care data for pediatric residents with emphasis on needs identified by residents and residency leadership. To …

Virtual Deliberate Practice Module For Tracheostomy Change Training: An Application Of Educational Design Research, Jennifer Christina Benjamin, Saul Flores, Parag Jain, Shelley Kumar, Satid Thammasitboon

Faculty, Staff and Students Publications

BACKGROUND: The pandemic poses challenges for in-person procedural skills training. We developed a virtual module for teaching hands-on tracheostomy skills.

OBJECTIVE: To develop and evaluate a virtual module prototype grounded in deliberate practice using tracheostomy change as an example.

METHODS: After identifying desirable features of a virtual module by surveying stakeholders, we designed a prototype using VoiceThread, a multimedia-based collaborative learning platform. We created an asynchronous module accessible to learners for repeated skill practice and for video upload of individual performance on a tracheostomy task trainer using personal devices. This virtual module provided a four-step coaching (demonstration, deconstruction, formulation, and …

Isoform-Specific Functions Of Pparγ In Gene Regulation And Metabolism, Wenxiang Hu, Chunjie Jiang, Mindy Kim, Yang Xiao, Hannah J Richter, Dongyin Guan, Kun Zhu, Brianna M Krusen, Arielle N Roberts, Jessica Miller, David J Steger, Mitchell A Lazar

Faculty, Staff and Students Publications

Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor that is a vital regulator of adipogenesis, insulin sensitivity, and lipid metabolism. Activation of PPARγ by antidiabetic thiazolidinediones (TZD) reverses insulin resistance but also leads to weight gain that limits the use of these drugs. There are two main PPARγ isoforms, but the specific functions of each are not established. Here we generated mouse lines in which endogenous PPARγ1 and PPARγ2 were epitope-tagged to interrogate isoform-specific genomic binding, and mice deficient in either PPARγ1 or PPARγ2 to assess isoform-specific gene regulation. Strikingly, although PPARγ1 and PPARγ2 contain identical DNA binding domains, …

Clinical Opinion: The Diagnosis And Management Of Suspected Fetal Growth Restriction: An Evidence-Based Approach, Christoph C Lees, Roberto Romero, Tamara Stampalija, Andrea Dall'asta, Greggory A Devore, Federico Prefumo, Tiziana Frusca, Gerard H A Visser, John C Hobbins, Ahmet A Baschat, Caterina M Bilardo, Henry L Galan, Stuart Campbell, Dev Maulik, Francesc Figueras, Wesley Lee, Julia Unterscheider, Herbert Valensise, Fabricio Da Silva Costa, Laurent J Salomon, Liona C Poon, Enrico Ferrazzi, Giancarlo Mari, Giuseppe Rizzo, John C Kingdom, Torvid Kiserud, Kurt Hecher

Faculty, Staff and Students Publications

This study reviewed the literature about the diagnosis, antepartum surveillance, and time of delivery of fetuses suspected to be small for gestational age or growth restricted. Several guidelines have been issued by major professional organizations, including the International Society of Ultrasound in Obstetrics and Gynecology and the Society for Maternal-Fetal Medicine. The differences in recommendations, in particular about Doppler velocimetry of the ductus venosus and middle cerebral artery, have created confusion among clinicians, and this review has intended to clarify and highlight the available evidence that is pertinent to clinical management. A fetus who is small for gestational age is …

Clinical Exome Sequencing Data Reveal High Diagnostic Yields For Congenital Diaphragmatic Hernia Plus (Cdh+) And New Phenotypic Expansions Involving Cdh, Tiana M Scott, Ian M Campbell, Andres Hernandez-Garcia, Seema R Lalani, Pengfei Liu, Chad A Shaw, Jill A Rosenfeld, Daryl A Scott

Duncan NRI Faculty and Staff Publications

Background: Congenital diaphragmatic hernia (CDH) is a life-threatening birth defect that often co-occurs with non-hernia-related anomalies (CDH+). While copy number variant (CNV) analysis is often employed as a diagnostic test for CDH+, clinical exome sequencing (ES) has not been universally adopted.

Methods: We analysed a clinical database of ~12 000 test results to determine the diagnostic yields of ES in CDH+ and to identify new phenotypic expansions.

Results: Among the 76 cases with an indication of CDH+, a molecular diagnosis was made in 28 cases for a diagnostic yield of 37% (28/76). A provisional diagnosis was made in seven other …

Visual Pigment-Deficient Cones Survive And Mediate Visual Signaling Despite The Lack Of Outer Segments, Hui Xu, Nange Jin, Jen-Zen Chuang, Zhao Zhang, Xiaoyue Zhong, Zhijing Zhang, Ching-Hwa Sung, Christophe P Ribelayga, Yingbin Fu

Faculty, Staff and Students Publications

Rhodopsin and cone opsins are essential for light detection in vertebrate rods and cones, respectively. It is well established that rhodopsin is required for rod phototransduction, outer segment disk morphogenesis, and rod viability. However, the roles of cone opsins are less well understood. In this study, we adopted a loss-of-function approach to investigate the physiological roles of cone opsins in mice. We showed that cones lacking cone opsins do not form normal outer segments due to the lack of disk morphogenesis. Surprisingly, cone opsin-deficient cones survive for at least 12 mo, which is in stark contrast to the rapid rod …

P16 Represses Dna Damage Repair Via A /Novel Ubiquitin-Dependent Signaling Cascade, David P Molkentine, Jessica M Molkentine, Kathleen A Bridges, David R Valdecanas, Annika Dhawan, Reshub Bahri, Andrew J Hefner, Manish Kumar, Liangpeng Yang, Mohamed Abdelhakiem, Phillip M Pifer, Vlad Sandulache, Aakash Sheth, Beth M Beadle, Howard D Thames, Kathryn A Mason, Curtis R Pickering, Raymond E Meyn, Heath D Skinner

Faculty, Staff and Students Publications

Squamous cell carcinoma driven by human papillomavirus (HPV) is more sensitive to DNA-damaging therapies than its HPV-negative counterpart. Here, we show that p16, the clinically used surrogate for HPV positivity, renders cells more sensitive to radiotherapy via a ubiquitin-dependent signaling pathway, linking high levels of this protein to increased activity of the transcription factor SP1, increased HUWE1 transcription, and degradation of ubiquitin-specific protease 7 (USP7) and TRIP12. Activation of this pathway in HPV-positive disease led to decreased homologous recombination and improved response to radiotherapy, a phenomenon that can be recapitulated in HPV-negative disease using USP7 inhibitors in clinical development. This …

Prolonged Drying Trend Coincident With The Demise Of Norse Settlement In Southern Greenland, Boyang Zhao, Isla S. Castañeda, Jeffrey M. Salacup, Elizabeth K. Thomas, William C. Daniels, Tobias Schneider, Gregory A. De Wet, Raymond S. Bradley

Geosciences: Faculty Publications

Declining temperature has been thought to explain the abandonment of Norse settlements, southern Greenland, in the early 15th century, although limited paleoclimate evidence is available from the inner settlement region itself. Here, we reconstruct the temperature and hydroclimate history from lake sediments at a site adjacent to a former Norse farm. We find no substantial temperature changes during the settlement period but rather that the region experienced a persistent drying trend, which peaked in the 16th century. Drier climate would have notably reduced grass production, which was essential for livestock overwintering, and this drying trend is concurrent with a Norse …

A Summer Program Goes Online: How Beam Served Students From Marginalized Backgrounds During Covid, Ramya Ramaswamy, Javier Ronquillo Rivera

Journal of Math Circles

Most summers, BEAM runs free summer programs for mathematically talented middle school students from low income, historically marginalized communities. Our programs are designed to deepen students' problem solving and mathematical reasoning skills, to foster their love of math, and to build a community centered around peers all interested in mathematics.

This summer, in response to the pandemic, we made the decision to shift our summer programming online and operate virtually for the first time. We crafted a program that we hoped would sustain many of our original programming goals.

This paper outlines the decisions made, the variables that affected implementation, …

What We Mean When We Say "Religion": The Q'Ero Migrants Of Cusco, Peru, Autumn J. Delong, Mirtha Irco

Journal of Gender, Ethnic, and Cross-Cultural Studies

This article is based upon ethnographic research conducted with Q’ero Indigenous migrants living in Cusco, Peru in the fall of 2018. The Q’ero community originates from the village of Paucartambo and the surrounding areas, about a three days’ trek northeast of the city. These stories collected from the migrants emphasize the centrality of their spirituality and worldview in defining their sense of identity apart from that of greater society. In their rituals, these migrants draw upon an experience of the sacred which is manifest through performance, discipline, and practice – often more so than through belief, faith, or intellectualism. Based …

How Do Teachers’ Unions Influence Vaccine Mandates?, Kristian Thymianos

Spectra Undergraduate Research Journal

The COVID-19 pandemic presented an array of policy problems for school districts across the country. This included balancing social distancing during in-person learning. The creation of the COVID-19 vaccine made in-person learning a more viable option again. However, the political polarization that surrounded COVID-19 extended to vaccines, with many communities experiencing hurdles in vaccinating their populace. Previous research shows how teachers’ unions influenced school district reopenings during the height of the pandemic in fall of 2020; this paper seeks to expand on this literature by looking at how teachers’ unions influence the adoption of vaccination mandates and testing. I test …

Implicit Bias Against Bipoc Patients In Clinical Settings: A Qualitative Review, Raisa Kabir, Sayeda Tazim Zaidi

Spectra Undergraduate Research Journal

Black, Indigenous, and People of Color (BIPOC) from stigmatized and marginalized communities face implicit bias in medicine. Implicit biases are unconscious attitudes and internalized discrimination developed through repeated practices based on stereotypes from a foundation of systematic racism. In clinical settings, it impacts individuals’ healthcare experience and treatment outcomes. This study aimed to characterize and address implicit bias among healthcare providers toward BIPOC patients in clinical settings. A literature search in MEDLINE/PubMed, CINAHL, PsyArticles, PsycINFO from EBSCO databases was conducted to include all peer-reviewed studies (2012-2021) about implicit bias toward BIPOC. Most healthcare providers have some form of implicit bias-positive …

The Gender Wage Gap As It Relates To State Partisan Control And Pay Equity Policy, Candace Wells

Spectra Undergraduate Research Journal

This study offers an explanation to the interstate variation of the gender wage gap in the United States. Looking at political explanations as an answer for the wage gap’s persistence, I hypothesize that Democratically controlled state government positively impacts the state having pay equity policies, and that having these pay equity policies positively impacts the state’s gender wage gap. Using U.S. Census Bureau, National Conference of State Legislatures, and American Association of University Women with U.S. Department of Labor Women’s Bureau data, I find that while there is a correlation between Democratically controlled state legislatures and pay equity policy and …

A Systematic Literature Review On The Resilience Reported By Bipoc In The Face Of Discrimination, Lianelys Cabrera Martinez, Aldo Barrita, Gloria Wong-Padoongpatt

Spectra Undergraduate Research Journal

The present study is a systematic literature review on the psychology of resilience, or the ability to bounce back after a difficult situation (Smith, 2008). Although resilience is a timely and relevant variable in social psychology, little is known about its connection to the racism-related experiences of Black, Indigenous, and People of Color (BIPOC). This review explores how resilience manifests in the BIPOC community and its influence on the identity of minority groups. Previous research has shown that BIPOC reports higher resilience (Carter, 2012); however, there is still uncertainty around its connection to discrimination. Through the analysis of nine final …

Promoting Ecotourism To Millennials Through Social Media, Melissa Clark, Paul Clark, Michael Latta

The Coastal Business Journal

This paper explores how coastal ecotourism marketers can utilize social media to effectively market to millennials. Coastal Tourism is one of four types of ecotourism identified by Honey and Krantz (2007) in their study Global Trends in Coastal Tourism sponsored by the World Wildlife Fund. An online survey of university students from the millennial generation was utilized. Findings indicate that millennials are interested in ecotourism and gather information about it from friends and social media. They check their accounts several times a day and usually from their smartphones. They would choose an ecotourism destination if money were not an issue. …

Small Business Identity And Entrepreneurial Identity In A Destination Resort Town: Are Birds Of A Feather Flocking To The Beach?, Janice A. Black, Carol Megehee, Frances H. Fabian

The Coastal Business Journal

Identities can be considered an intangible resource when they support the competitive advantage of a firm. Some work has shown that the context of an organization matters but will that hold true at a beach location filled with large numbers of micro-businesses and small businesses where entrepreneurs and small business owners engage their world both as individuals and as organizations? We examine the literature on identity and utilize a zoomorphic metaphor to elicit unbiased understandings of the coherence or dissonance of entrepreneurial and organizational identities. We found some intriguing results showing unexpected similarities and an affinity for coherent identities.

Distribution And Movements Of Bottlenose Dolphins (Tursiops Truncatus) Along The Northern South Carolina Coast: A Research Partnership With Ecotourism, Courtney N. Dunn, Dani C. Silva, Emily P. Deborde, Robert F. Young

The Coastal Business Journal

Assessments of bottlenose dolphin stocks rely on current information about the distribution and abundance of specific populations. We partnered with two ecotourism dolphin watch businesses to investigate bottlenose dolphins along the northern South Carolina coast. The temporal and spatial distribution of dolphins was examined by comparing dorsal fin images from research-based surveys with photo-identification efforts from commercial dolphin watch groups. Matches between survey locations and times revealed patterns of seasonal residency, potential migratory dispersal between seasons, and variable patterns for home range size. An enhanced understanding of the structure of local populations will contribute to the management of local fisheries, …

Importance-Performance Analysis Of Relocation Attributes In The Coastal Carolina Region, Bomi Kang, Kimberly Warne, Kay Keels

The Coastal Business Journal

Domestic migration to the Carolina coastal region has increased dramatically between 2005 and 2009. This influx has spurred substantial increases in the demand for housing, support services, employment and infrastructure. The continued increase in such services is dependent upon on-going financial support which, in turn, is contingent upon the stability and/or continued growth of the population in this region. This study identifies the social and economic factors considered to be important by these in-migrants as well as their perceptions of how well these factors perform. In addition, the study addresses the relationship between community attachment and individual migration intent. The …

Agri-Tainment: Combining Agriculture And Entertainment Along The Grand Strand, Mark Mitchell, L. Taylor Damonte, Darla J. Domke-Damonte

The Coastal Business Journal

This paper provides an overview of the benefits sought by consumers from Agri-tainment venues and the challenges of establishing such venues. The paper begins by defining Agri-tainment, and providing examples of established Agri-tainment venues across the United States and within the Grand Strand area of South Carolina. It then provides a series of Supporting Statements regarding likely benefits and Cautionary Statements associated with Agri-tainment, and concludes with potential resources for expanding the offering of Agri-tainment venues along the Grand Strand.

Dressing The Part: Women's Roles And Costumes In1939 America, Christie Genochio

Historical Perspectives: Santa Clara University Undergraduate Journal of History, Series II

No abstract provided.

Historical Perspectives Vol. 12 2007

Historical Perspectives: Santa Clara University Undergraduate Journal of History, Series II

No abstract provided.