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A Comparative Analysis Of Domestic Violence Legislation In India And The United States: Understanding Protection Of Women Against Violence Act 2005 And Violence Against Women Act 1994, Deon Rodrigues Dec 2025

A Comparative Analysis Of Domestic Violence Legislation In India And The United States: Understanding Protection Of Women Against Violence Act 2005 And Violence Against Women Act 1994, Deon Rodrigues

2025 Fall Honors Capstones Projects - Archive

Domestic violence continues to affect millions of individuals worldwide, yet legal systems respond to it in very different ways. This research compares how India’s Protection of Women from Domestic Violence Act (2005) and the United States’ Violence Against Women Act (1994; 2021) protect victims and hold offenders accountable. Using a comparative legal analysis, the study examines both laws’ language, enforcement mechanisms, and effectiveness through court cases, government reports, and statistical data. By identifying the strengths of the United States model such as mandatory arrest provisions and victim support systems, the study aims to propose practical reforms for India’s legal framework. …


Investigating The Polygenic Relationship Between Heavy Cannabis Use And Schizophrenia In The All Of Us Research Program, Isabelle Austin-Zimmerman, Hayley H A Thorpe, John J Meredith, Jibran Y Khokhar, Tian Ge, Marta Di Forti, Arpana Agrawal, Emma C Johnson, Sandra Sanchez-Roige Dec 2025

Investigating The Polygenic Relationship Between Heavy Cannabis Use And Schizophrenia In The All Of Us Research Program, Isabelle Austin-Zimmerman, Hayley H A Thorpe, John J Meredith, Jibran Y Khokhar, Tian Ge, Marta Di Forti, Arpana Agrawal, Emma C Johnson, Sandra Sanchez-Roige

2020-Current year OA Pubs

BACKGROUND: Decades of research have identified a strong association between heavy cannabis use and schizophrenia (SCZ), with evidence of correlated genetic factors. However, many studies on the genetic relationship between cannabis use and psychosis have lacked data on both phenotypes within the same individuals, creating challenges due to unmeasured confounding. We aimed to address this by using multimodal data from the All of Us Research Program, which contains genetic data as well as information on SCZ diagnosis and cannabis use.

METHODS: We tested the association between cannabis use disorder (CUD) and SCZ polygenic scores (PGSs) with SCZ and heavy cannabis …


Resolutions, Radio, Razzle Dazzle, Resilience, And Rachamim: An American Initiative For The Jews During The Jewish Refugee Crisis And The Holocaust, Holly Ann Sproule Dec 2025

Resolutions, Radio, Razzle Dazzle, Resilience, And Rachamim: An American Initiative For The Jews During The Jewish Refugee Crisis And The Holocaust, Holly Ann Sproule

Doctoral Dissertations and Projects

Since the 1960s, historians have focused on American inaction during the Holocaust, concluding that the War Refugee Board (WRB) was the definitive involvement of the United States in aiding the Jews in Nazi occupied Europe. Consequently, American aid efforts preceding the creation of the WRB remain unfamiliar and underexplored. By examining the Foreign Relations Diplomatic collections of the Office of the Historian, the databases of the United States Holocaust Memorial Museum, and qualitative research, this dissertation argues that there was a dynamic American initiative in Jewish aid and rescue preceding the War Refugee Board. Through analysis of government and organizational …


Leaving The Fold: Young Adult Disaffiliation From Protestantism In Political And Cultural Context, Kimberly S. Johnson Dec 2025

Leaving The Fold: Young Adult Disaffiliation From Protestantism In Political And Cultural Context, Kimberly S. Johnson

Doctoral Dissertations and Projects

This study investigated the lived experiences of young adults who have disaffiliated from a Protestant church, focusing on political, national, and religious dynamics, including reflections on Christian Nationalism. The study also examines how these meaning-making processes informed participants’ retrospective accounts of disaffiliation. Building on the quantitative research that has dominated prior studies, this study employed interpretative phenomenological analysis to investigate how encounters with Christian Nationalism have shaped perceptions of organized religion. The study’s ten participants ranged in age from 21 to 29 years old and identified as having been part of the Protestant Church prior to disaffiliating from organized religion. …


Energy Input–Output Meta-Analysis Reveals Algal Diesel Struggles To Break Even, Michelle M. Arnold, David J. R. Murphy, Christopher L. Lant Dec 2025

Energy Input–Output Meta-Analysis Reveals Algal Diesel Struggles To Break Even, Michelle M. Arnold, David J. R. Murphy, Christopher L. Lant

Environment and Society Student Research

Algal biofuels have been investigated as an alternative to fossil fuels and first-generation biofuels for transportation in the United States since the 1970s. Yet after five decades of development, scalability and implementation remain limited—largely due to persistent barriers such as low biomass productivity, modest lipid yields, and energy-intensive processing methods. These technical challenges significantly constrain the feasibility of large-scale commercialization despite substantial research and investment. To evaluate progress toward commercial viability, this study harmonized energy inputs and outputs across 508 observations on the production of algal biofuel energy return on energy investment (EROEI) in the United States. While bioethanol achieves …


Comparative Study Of Vocal Pedagogy Systems In South Korea And The United States: Developmental Strategies For Classical Voice Education In South Korea, Dongmin Byeon Dec 2025

Comparative Study Of Vocal Pedagogy Systems In South Korea And The United States: Developmental Strategies For Classical Voice Education In South Korea, Dongmin Byeon

UNLV Theses, Dissertations, Professional Papers, and Capstones

This dissertation presents a comparative study of vocal pedagogy systems in South Korea and the United States, with the aim of identifying deficiencies in Korean higher education and proposing strategies for reform. While South Korean university voice programs are deeply rooted in the traditional master–apprentice model and rely heavily on anecdotal teaching methods, U.S. institutions have developed structured, evidence-based pedagogical frameworks informed by anatomy, physiology, acoustics, and voice science. This research explores the historical evolution of vocal pedagogy in both countries, highlighting how traditional practices in Korea, though culturally significant, have not sufficiently adapted to contemporary scientific standards.

Employing qualitative …


Transdiagnostic Links Of Reward Processing In Obsessive-Compulsive Disorder And Depression, Kevin M Wagner, Matti Cervin, Jessica S C Cheng, Jasmine Arriaga, Vanessa Zavala Cruz, Dayan Berrones, Josselyn S Muñoz, Renee M Frederick, Jacey L Anderberg, Belinda E Núñez Bracho, Victor R Adorno, Leonardo F Fontenelle, Andrew D Wiese, Latin American Trans-Ancestry Initiative For Ocd Genomics (Latino), Brazilian Obsessive-Compulsive Spectrum Disorder Working Group (Gttoc), James J Crowley, Eric A Storch Dec 2025

Transdiagnostic Links Of Reward Processing In Obsessive-Compulsive Disorder And Depression, Kevin M Wagner, Matti Cervin, Jessica S C Cheng, Jasmine Arriaga, Vanessa Zavala Cruz, Dayan Berrones, Josselyn S Muñoz, Renee M Frederick, Jacey L Anderberg, Belinda E Núñez Bracho, Victor R Adorno, Leonardo F Fontenelle, Andrew D Wiese, Latin American Trans-Ancestry Initiative For Ocd Genomics (Latino), Brazilian Obsessive-Compulsive Spectrum Disorder Working Group (Gttoc), James J Crowley, Eric A Storch

Faculty, Staff and Students Publications

Objectives: Transdiagnostic models aim to uncover shared mechanisms across mental disorders. Reward responsiveness (the ability to experience pleasure from rewarding stimuli) is a plausible, yet underexplored, transdiagnostic mechanism linking obsessive-compulsive disorder (OCD) and depression. This study used network analysis to (1) examine how key reward responsiveness domains are interlinked in individuals with OCD and (2) explore how each domain is uniquely associated with OCD and depression.

Methods: A total of 1345 individuals with a history of OCD symptoms (ages 18-88, 71 % women) from Latino communities in the United States (including Puerto Rico) and nine Latin American countries completed validated …


Genetics Of Aluminum Tolerance And Diversity In United States Vigna Unguiculata Germplasm, Max Carl Miller Dec 2025

Genetics Of Aluminum Tolerance And Diversity In United States Vigna Unguiculata Germplasm, Max Carl Miller

Tennessee State University Alumni Theses and Dissertations

Cowpea (Vigna unguiculata L. Walp) is an annual legume of immense importance across the world. However, knowledge of its ability to tolerate aluminum (Al) at toxic levels is not as comprehensive. This stress is an issue globally and especially in the southeastern United States, which has many Al-toxic soils. Here we determined multiple cultivars both tolerant and susceptible to Al toxicity. This was expounded upon by employing RNA sequencing on two cultivars from the United States with significantly different tolerance levels to characterize genes and pathways associated with Al toxicity and response. Multiple well-established gene orthologs like STOP, STAR, and …


Representation In Science And Trust In Scientists In The Usa, James Druckman, Katherine Ognyanova, Alauna Safarpour, Jonathan Schulman, Kristin Lunz Trujillo, Ata Aydin Uslu, Jon Green, Matthew Baum, Alexi Quintana Mathe, Hong Qu, Roy Perlis, David Lazer Dec 2025

Representation In Science And Trust In Scientists In The Usa, James Druckman, Katherine Ognyanova, Alauna Safarpour, Jonathan Schulman, Kristin Lunz Trujillo, Ata Aydin Uslu, Jon Green, Matthew Baum, Alexi Quintana Mathe, Hong Qu, Roy Perlis, David Lazer

Political Science Faculty Publications

Scientists provide important information to the public. Whether that information influences decision-making depends on trust. In the USA, gaps in trust in scientists have been stable for 50 years: women, Black people, rural residents, religious people, less educated people and people with lower economic status express less trust than their counterparts (who are more represented among scientists). Here the authors probe the factors that influence trust. They find that members of the less trusting groups exhibit greater trust in scientists who share their characteristics (for example, women trust women scientists more than men scientists). They view such scientists as having …


Authoring Culture: The Foundations Of Twenty-First Century Writing Suggested Assignment, Columbia College Chicago Dec 2025

Authoring Culture: The Foundations Of Twenty-First Century Writing Suggested Assignment, Columbia College Chicago

Authoring Culture: Foundations of Twenty-First Century Writing

A suggested classroom assignment to accompany the Genre and Ethos chapters in Authoring Culture: Foundations of Twenty-First Century Writing .


Ticking Away: A Study On How Multiple Sclerosis Patients In The Us And Australia Navigate Their Day, Ella M. Stahl Dec 2025

Ticking Away: A Study On How Multiple Sclerosis Patients In The Us And Australia Navigate Their Day, Ella M. Stahl

Honors Theses

Multiple Sclerosis (MS) is an autoimmune disease that damages the nervous system. Individuals diagnosed with MS experience a wide variety of symptoms, the most common being fatigue and numbness in the hands and feet. This disease affects close to three million people worldwide. Current research shows that individuals with chronic conditions spend more time managing their medical issues, therefore impacting their quality of life. This study compares time use of Multiple Sclerosis patients in the US and Australia. The central investigative question is: what are the differences and similarities in time use of those diagnosed with MS in the United …


Telehealth And Virtual Supervision Practices For Health Professions Education In The Department Of Veterans Affairs, Nancy D. Harada, Kimberly Falco, Marjorie Bowman, John M. Byrne Dec 2025

Telehealth And Virtual Supervision Practices For Health Professions Education In The Department Of Veterans Affairs, Nancy D. Harada, Kimberly Falco, Marjorie Bowman, John M. Byrne

Population and Public Health Sciences Faculty Publications

Background Telehealth and virtual supervision practices in health professions clinical education has grown rapidly, including in the Department of Veterans Affairs (VA) which oversees the largest interprofessional training effort in the United States. Telehealth is the provision of healthcare that is provided remotely through telecommunication technology, and virtual supervision is clinical supervision of health professions trainees (HPTs) that occurs through telecommunication technology. In this study we evaluate participation in telehealth and virtual supervision for physician, nursing, and associated health HPTs, and describe prevalent themes concerning HPT perceptions of telehealth and virtual supervision. Methods The survey study cohort included 10,865 HPTs …


An Analysis Of Policies Impacting Ex-Offenders And The Barriers Created In Their Transition Into Society: A Qualitative Metasynthesis, Thomas A. Ayala Dec 2025

An Analysis Of Policies Impacting Ex-Offenders And The Barriers Created In Their Transition Into Society: A Qualitative Metasynthesis, Thomas A. Ayala

Theses & Dissertations

In 2018, more than six million people in the United States were under correctional supervision, including incarceration, probation, or parole, equivalent to 1 in 40 adults (Maruschak & Minton, 2020). While this reflects a decline from previous years, prison populations reversed course in 2022, increasing by 2% nationwide, with 36 states and federal facilities reporting higher inmate counts (Nellis, 2024). Since 1973, policy shifts have fueled the rise of mass incarceration (Nellis, 2021; O’Brien, 2020). According to the Pew Center, the United States remains a global outlier, holding 5% of the world’s population, but incarcerates 25% of the 9 million …


Knowing One's Place At The Table: Taste As A Means Of Othering In The American Colonies, 1700-1775, Nicholas Harp Dec 2025

Knowing One's Place At The Table: Taste As A Means Of Othering In The American Colonies, 1700-1775, Nicholas Harp

Master's Theses or Doctor of Nursing Practice

This thesis began as an inquiry into a simple question. How did people in the American colonies talk about the food that they ate? This question led to a fascinating look into the social dynamics of the people living in eighteenth century America. Their own personal writings demonstrate how they understood their place in society through the food that they ate. Moreover, they often wrote about the way that other people ate in ways that alienated or discriminated against different ethnic groups. A look into the secondary historiography revealed that other historians had noticed this trend. However, very few addressed …


Coming To The American Vincentian Mission In 1818: The Second Journey, John E. Rybolt C.M. Dec 2025

Coming To The American Vincentian Mission In 1818: The Second Journey, John E. Rybolt C.M.

Vincentian Studies

Three letters from Francesco Cellini, a Vincentian novice, and his confrere, Filippo Borgna, a Vincentian student with vows, are given or summarized here. In 1818, Cellini and Borgna made an eighty-eight-day voyage from Livorno, Italy, to the United States. Cellini wrote an account to a friend in Rome, and Borgna largely copied this in his letter, perhaps to ensure that one of their texts would survive the trip back to Italy. These are the only known detailed records of the Vincentians’ second journey to the US and reinforce records kept by Felix De Andreis and Joseph Rosati, who came two …


The Impact Of The 2008 Financial Crisis On Crime And Cybercrime In The United States, Rashed Adel Alsuwaidi Dec 2025

The Impact Of The 2008 Financial Crisis On Crime And Cybercrime In The United States, Rashed Adel Alsuwaidi

Theses

This thesis will examine how the traditional crime and cy- were affected by the 2008 financial crisis. United States are also experiencing a rise in crime between 2005 and 2012. Based on the FBI data at the national level. The Internet Crime Complaint Center (IC3), Uniform Crime Reports and important economic indicators. The study, which involves tors, including unemployment, GDP, rates of foreclosures, and mortgage rates, is a combination. correlationbased interpretation supported by exploratory descriptive trend analysis. model-fit checks. The results indicate that contrary to the conventional expectations, violent and property crime also maintained their long-term reduction during the period …


The Civic Oath At Saint-Lazare, 1790, John E. Rybolt C.M. Dec 2025

The Civic Oath At Saint-Lazare, 1790, John E. Rybolt C.M.

Vincentian Studies

This study presents the French text, English translation, historical context, and a brief analysis of the speech given at Saint-Lazare on the civic oath-taking in support of the 1790 revolutionary government in France, which every adult citizen had to do publicly. At Saint-Lazare, a group of Vincentians and their neighbors assembled in the motherhouse’s chapel for the oath. This very rare and virtually unknown document is in Richardson Library’s special collections at DePaul University in Chicago. Oath-taking was a way of replacing royal legal authority before assemblies of citizens had been formed. By the time of this oath on 7 …


Three Additional Texts From Felix De Andreis, John E. Rybolt C.M. Dec 2025

Three Additional Texts From Felix De Andreis, John E. Rybolt C.M.

Vincentian Studies

Three texts add to our knowledge of the work of Felix De Andreis (1778–1820), the founding superior of the Congregation of the Mission in the United States. These have recently come to light. Two are originals, and the third is a copy. They are given in the original languages and in English, with introduction and commentary. The first is an “Indian grammar” with the Lord’s Prayer and catechism by Felix De Andreis, written circa 1817. According to David J. Costa, a scholar in Native American linguistics, it “provide[s] us with the only source of data that is clearly transitional between …


Louis William Valentine Dubourg: His First Years As Bishop Of Louisiana, John E. Rybolt C.M. Dec 2025

Louis William Valentine Dubourg: His First Years As Bishop Of Louisiana, John E. Rybolt C.M.

Vincentian Studies

Louis William Valentine Dubourg, a priest of the Society of Saint Sulpice, invited the Vincentians to establish a seminary for his diocese of Louisiana. Part of his fundraising efforts to support these and other works was this booklet, The Notice sur l’état actuel de la Mission de la Louisiane (Notice Concerning the Current State of the Mission of Louisiana). Printed in 1820, it circulated widely in Europe and was corrected, updated, and reprinted twice in 1822. Transcriptions given here illuminate differences between the editions. The booklet’s author is anonymous but is probably Charles de la Croix, the bishop’s secretary. The …


Short-Term Preeclampsia Prediction: Cutoff Variations For Sflt-1/Plgf In U.S. Patients With Or Without Hypertensive Disorders, Yaxin Li, Kristen Cagino, Jim Yee, Caroline Andy, Dajana Borova, Ayush Shah, Isla Racine, Tracy Grossman, Zhen Zhao Dec 2025

Short-Term Preeclampsia Prediction: Cutoff Variations For Sflt-1/Plgf In U.S. Patients With Or Without Hypertensive Disorders, Yaxin Li, Kristen Cagino, Jim Yee, Caroline Andy, Dajana Borova, Ayush Shah, Isla Racine, Tracy Grossman, Zhen Zhao

Student Papers, Posters & Projects

BACKGROUND: Preeclampsia (PE) is a complex disorder with significant maternal and fetal risks. The soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) ratio shows promise as a diagnostic tool, but its adoption in the U.S. remains limited due to the lack of accessible testing platforms, U.S.-based studies, and evidence-based implementation guidelines.

PATIENTS/MATERIALS AND METHODS: We conducted a cohort study to evaluate the sFlt-1/PlGF ratio for predicting PE within two weeks among pregnant individuals ≥18 years, ≥20 weeks gestation. Serum samples were obtained from routine prenatal visits or triage evaluations. sFlt-1/PlGF ratios were measured using Roche Elecsys assays, and …


Fludarabine Lymphodepletion Exposure Is Associated With Toxicities After Idecabtagene-Vicleucel In Relapsed/Refractory Multiple Myeloma: Real-World Experience From The Us Myeloma Immunotherapy Consortium, Karen Sweiss, Charlotte Wagner, Eric Anto, Tom Greene, Ryan Sun, Rebecca Gonzalez, Omar Castaneda Puglianini, Ciara Freeman, Filip Ionescu, Krina Patel, Christopher Ferreri, Mahmoud Gaballa, Leyla Shune, Joseph Mcguirk, Surbhi Sidana, Vanna Hovanky, Jack Khouri, Shahzad Raza, Faiz Anwer, Danai Dima, Hamza Hashmi, James Davis, Aimaz Afrough, Gurbakhash Kaur, Larry Anderson, Peter Forsberg, Megan Herr, Doris K Hansen, Mehmet Hakan Kocoglu, Douglas Sborov Dec 2025

Fludarabine Lymphodepletion Exposure Is Associated With Toxicities After Idecabtagene-Vicleucel In Relapsed/Refractory Multiple Myeloma: Real-World Experience From The Us Myeloma Immunotherapy Consortium, Karen Sweiss, Charlotte Wagner, Eric Anto, Tom Greene, Ryan Sun, Rebecca Gonzalez, Omar Castaneda Puglianini, Ciara Freeman, Filip Ionescu, Krina Patel, Christopher Ferreri, Mahmoud Gaballa, Leyla Shune, Joseph Mcguirk, Surbhi Sidana, Vanna Hovanky, Jack Khouri, Shahzad Raza, Faiz Anwer, Danai Dima, Hamza Hashmi, James Davis, Aimaz Afrough, Gurbakhash Kaur, Larry Anderson, Peter Forsberg, Megan Herr, Doris K Hansen, Mehmet Hakan Kocoglu, Douglas Sborov

Faculty, Staff and Student Publications

Background: Idecabtagene vicleucel (ide-cel) is a BCMA-directed CAR-T associated with high response rates in relapsed/refractory multiple myeloma (RRMM), yet responses are not durable and most patients experience toxicities. Fludarabine (Flu) is a key component of lymphodepletion but exhibits significant pharmacokinetic (PK) variability.

Objective: Given Flu exposure (AUC) predicts outcomes after CD19-directed CAR-T, we hypothesized it would predict outcomes after ide-cel. Our objective was to determine the association between fludarabine AUC and clinical outcomes after standard-of-care (SOC) ide-cel.

Study design: RRMM patients receiving ide-cel from 10 US Multiple Myeloma Immunotherapy Consortium centers were retrospectively analyzed. A population PK approach using cumulative …


A Contemporary Guide To An International Aortic Super-Fellowship For Surgical Trainees And Surgeons In The United States, Roberto G. Aru, Adam W. Beck, Stéphan Haulon Dec 2025

A Contemporary Guide To An International Aortic Super-Fellowship For Surgical Trainees And Surgeons In The United States, Roberto G. Aru, Adam W. Beck, Stéphan Haulon

Department of Surgery Faculty Papers

Fenestrated and branched technology for endovascular aortic repair of the thoracoabdominal aorta and aortic arch has evolved significantly over the last decade. The spectrum of these devices is largely available outside the United States (US), while patient-specific company manufactured devices are limited to ten sites in the US, with ongoing expanding use of market-approved off-the-shelf devices. The necessary environment for appropriate education to ensure safe dissemination of these technologies is limited, and the current centralization of both device availability and skillsets affects trainee education. In order to refine their endovascular treatment algorithm and planning/implantation skillsets at these multidisciplinary aortic centers, …


Short-Term Preeclampsia Prediction: Cutoff Variations For Sflt-1/Plgf In U.S. Patients With Or Without Hypertensive Disorders, Yaxin Li, Kristen Cagino, Jim Yee, Caroline Andy, Dajana Borova, Ayush Shah, Isla Racine, Tracy B Grossman, Zhen Zhao Dec 2025

Short-Term Preeclampsia Prediction: Cutoff Variations For Sflt-1/Plgf In U.S. Patients With Or Without Hypertensive Disorders, Yaxin Li, Kristen Cagino, Jim Yee, Caroline Andy, Dajana Borova, Ayush Shah, Isla Racine, Tracy B Grossman, Zhen Zhao

Faculty, Staff and Student Publications

Background: Preeclampsia (PE) is a complex disorder with significant maternal and fetal risks. The soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) ratio shows promise as a diagnostic tool, but its adoption in the U.S. remains limited due to the lack of accessible testing platforms, U.S.-based studies, and evidence-based implementation guidelines.

Patients/materials and methods: We conducted a cohort study to evaluate the sFlt-1/PlGF ratio for predicting PE within two weeks among pregnant individuals ≥18 years, ≥20 weeks gestation. Serum samples were obtained from routine prenatal visits or triage evaluations. sFlt-1/PlGF ratios were measured using Roche Elecsys assays, and …


Developing Consensus For A More Provider-Friendly Next-Generation Sequencing Molecular Biomarker Report: A Joint Consensus Recommendation Of The Association For Molecular Pathology And College Of American Pathologists, Jane Gibson, Hanadi El Achi, Dana Altenburger, Noah Brown, Amy S Clark, Joshua Coleman, Rajyasree Emmadi, Amber M Fussell, Meera Hameed, Danielle Jordan, Jennifer Laudadio, Anthony Provenzano, Robyn L Temple-Smolkin, Christopher G Suciu Dec 2025

Developing Consensus For A More Provider-Friendly Next-Generation Sequencing Molecular Biomarker Report: A Joint Consensus Recommendation Of The Association For Molecular Pathology And College Of American Pathologists, Jane Gibson, Hanadi El Achi, Dana Altenburger, Noah Brown, Amy S Clark, Joshua Coleman, Rajyasree Emmadi, Amber M Fussell, Meera Hameed, Danielle Jordan, Jennifer Laudadio, Anthony Provenzano, Robyn L Temple-Smolkin, Christopher G Suciu

Faculty, Staff and Student Publications

Despite the increasing availability of next-generation sequencing (NGS) gene panel analysis for cancers, published reports suggest underutilization of testing, citing the shortage of credentialed professionals available to assist with the interpretation of test results among the key barriers. Obtaining a multidisciplinary consensus regarding a shared best practice NGS molecular biomarker reporting section template may facilitate introduction and/or increased testing for institutions that adopt similar report structures by improving report effectiveness and efficiency for both health care providers and laboratory professionals, leading to improved patient care. To address this challenge, the Association for Molecular Pathology convened a multidisciplinary collaborative expert working …


Real-World Disease Burden And Health Care Resource Utilization For Patients With Barth Syndrome, Lindsay Marjoram, Yonglin Huang, Mary Kay Koenig, Bruce H Cohen, Eric Anderson Dec 2025

Real-World Disease Burden And Health Care Resource Utilization For Patients With Barth Syndrome, Lindsay Marjoram, Yonglin Huang, Mary Kay Koenig, Bruce H Cohen, Eric Anderson

Faculty, Staff and Student Publications

Background: Barth syndrome (BTHS) is an ultra-rare, X-linked genetic disorder for which there is limited economic data. Because compiling such data that target rare indications is difficult, we assessed real-world data to increase understanding of the cost of BTHS based on disease burden and health care resource utilization (HCRU).

Methods: A search of the published medical literature identified individual case studies and registry data used to assess the burden of disease and potential costs associated with BTHS, including the potential ability of developing treatments to positively impact those costs. In addition, a claims database analysis was conducted to assess HCRU …


Adherence To Breast Cancer Screening Guidelines Among Age-Eligible Us Women: Findings From Nhis 2021, Monalisa Chandra, Joël Fokom Domgue, Robert Yu, Sanjay Shete Dec 2025

Adherence To Breast Cancer Screening Guidelines Among Age-Eligible Us Women: Findings From Nhis 2021, Monalisa Chandra, Joël Fokom Domgue, Robert Yu, Sanjay Shete

Faculty, Staff and Student Publications

Background: Despite the proven benefits of early breast cancer detection in reducing mortality, adherence to breast cancer screening guidelines in the United States is suboptimal. In this study, we assessed the prevalence and factors associated with adherence to breast cancer screening guidelines.

Methods: Using nationally representative data from the National Health Interview Survey 2021, we included breast cancer screening-eligible women (aged 50-74). Descriptive statistics and population-weighted multivariable logistic regression were employed to examine breast cancer screening adherence per the United States Preventive Services Task Force guidelines, and its determinants in this population.

Results: Of the 6814 screening-eligible women included in …


Trends In Hospital Resource Use For Children With Complex Chronic Conditions., Nathaniel D. Bayer, Matthew Hall, Maria Osipovich, John M. Morrison, Christian D. Pulcini, Jana C. Leary, Joanna E. Thomson, Tamara D. Simon, Dennis Z. Kuo, Jeffrey D. Colvin, Eyal Cohen, Jay G. Berry Dec 2025

Trends In Hospital Resource Use For Children With Complex Chronic Conditions., Nathaniel D. Bayer, Matthew Hall, Maria Osipovich, John M. Morrison, Christian D. Pulcini, Jana C. Leary, Joanna E. Thomson, Tamara D. Simon, Dennis Z. Kuo, Jeffrey D. Colvin, Eyal Cohen, Jay G. Berry

Manuscripts, Articles, Book Chapters and Other Papers

IMPORTANCE: Despite a small prevalence, children with complex chronic conditions (CCCs) use substantial inpatient resources.

OBJECTIVE: To assess national trends in hospital discharges, bed days, and hospital charges for children with and without CCCs in the US from 2000 to 2022.

DESIGN, SETTING, AND PARTICIPANTS: This retrospective, repeated cross-sectional study used hospital discharge data from the Kids' Inpatient Database (KID) from the years 2000, 2003, 2006, 2009, 2012, 2016, 2019, and 2022 for US children aged 0 to 18 years, excluding uncomplicated newborn discharges.

EXPOSURE: Presence of 0, 1, 2, or 3 or more CCCs.

MAIN OUTCOMES AND MEASURES: Trends …


Evaluating Energy Transition Winners And Losers: Are Algae Biofuels Desirable, Feasible, And Viable?, Michelle M. Arnold Dec 2025

Evaluating Energy Transition Winners And Losers: Are Algae Biofuels Desirable, Feasible, And Viable?, Michelle M. Arnold

All Graduate Theses and Dissertations, Fall 2023 to Present

Climate change, environmental degradation, finite resources, and the uneven distribution of energy access all points to an urgent need for a global energy transition. But making that transition responsibly requires more than enthusiasm for “green” solutions—it demands careful evaluation of which energy sources are truly worth investing in. This dissertation develops a practical decision-making framework to help policymakers, scientists, and the public answer three foundational questions about any new energy technology: Is it desirable? Is it feasible? Is it viable? By systematically weighing public narratives, biophysical constraints, and patterns of innovation, the framework aims to prevent wasted time, funding, and …


Telemedicine Preexposure Prophylaxis Prescribing From A Large Online Us Company, Aaron J Siegler, Shi Hao Ernest Koh, Tristan Schukraft, Simon Mazzoni, Edwin Corbin-Gutierrez, Rupa R Patel, Patrick S Sullivan, Wenting Huang Dec 2025

Telemedicine Preexposure Prophylaxis Prescribing From A Large Online Us Company, Aaron J Siegler, Shi Hao Ernest Koh, Tristan Schukraft, Simon Mazzoni, Edwin Corbin-Gutierrez, Rupa R Patel, Patrick S Sullivan, Wenting Huang

2020-Current year OA Pubs

IMPORTANCE: HIV preexposure prophylaxis (PrEP) is highly effective in HIV prevention; telemedicine is a promising avenue for delivering PrEP care.

OBJECTIVE: To explore telemedicine delivery of PrEP care (telePrEP) by the largest telePrEP company in the US.

DESIGN, SETTING, AND PARTICIPANTS: This retrospective, single-arm cohort study used health record data of patients receiving telePrEP from MISTR LLC, a for-profit telehealth company, from November 27, 2018, to March 5, 2025. Patient characteristics and AIDSVu data were assessed to determine levels of PrEP use nationally. Retention in care was assessed for persons initiating PrEP in 2020, 2021, and 2022. Data were analyzed …


Modeling Reemergence Of Vaccine-Eliminated Infectious Diseases Under Declining Vaccination In The United States, Mathew V Kiang, Kate M Bubar, Yvonne Maldonado, Peter J Hotez, Nathan C Lo Dec 2025

Modeling Reemergence Of Vaccine-Eliminated Infectious Diseases Under Declining Vaccination In The United States, Mathew V Kiang, Kate M Bubar, Yvonne Maldonado, Peter J Hotez, Nathan C Lo

Faculty, Staff and Students Publications

(Abstracted from JAMA 2025;333(24):2176-2187) The development of childhood vaccine protocols has led to the elimination of many infectious diseases from the United States, including measles, rubella, diphtheria, and polio, by maintaining herd immunity. In recent years, especially since the COVID-19 pandemic, vaccination rates have declined due to policy changes, misinformation, distrust, and broader societal shifts.