Digital Commons Network^™

Single-Agent Mosunetuzumab Shows Durable Complete Responses In Patients With Relapsed Or Refractory B-Cell Lymphomas: Phase I Dose-Escalation Study, Lihua E Budde, Nancy L Bartlett, Et Al

2020-Current year OA Pubs

PURPOSE: Mosunetuzumab is a bispecific antibody targeting CD20 and CD3 that redirects T cells to engage and eliminate malignant B cells and is being developed for relapsed or refractory (R/R) B-cell non-Hodgkin lymphomas (B-NHLs).

METHODS: This first-in-human trial (ClinicalTrials.gov identifier: NCT02500407) evaluated the safety and tolerability and efficacy of mosunetuzumab in patients with R/R B-NHL and established the recommended phase II dose. Data from dose escalation are presented. Single-agent mosunetuzumab was administered intravenously in 3-week cycles, at full dose in cycle 1 day 1 (group A) or with ascending (step-up) doses during cycle 1 on days 1, 8, and 15 …

The Role Of Urgent Care Centers In Headache Management: A Quality Improvement Project, Mia T. Minen, Dennique Khanns, Jenny Guiracocha, Annika Ehrlich, Fawad A. Khan, Ashhar S. Ali, Marius Birlea, Niranjan N. Singh, Addie Peretz, I. V. Larry Charleston

Neurology Articles

BACKGROUND: Patients with headache often seek urgent medical care to treat pain and associated symptoms that do not respond to therapeutic options at home. Urgent Cares (UCs) may be suitable for the evaluation and treatment of such patients but there is little data on how headache is evaluated in UC settings and what types of treatments are available. We conducted a study to evaluate the types of care available for patients with headache presenting to UCs.

DESIGN: Cross-Sectional.

METHODS: Headache specialists across the United States contacted UCs to collect data on a questionnaire. Questions asked about UC staffing (e.g. number …

2022 Gray Wolf Questions And Answers, United States Fish And Wildlife Service

United States Fish and Wildlife Service: Publications

2022 Gray Wolf Questions and Answers

What does the February 10, 2022, ruling mean?

How does this ruling affect wolves in the Northern Rocky Mountains?

When does the court decision to vacate the delisting rule go into effect?

What is the legal status of gray wolves as of this ruling?

Is the Service continuing its status review of wolves in the western United States?

Is emergency listing an option for the Northern Rocky Mountain population?

Are wolf hunts going to stop as a result of the court decision?

How does this ruling affect wolves in Yellowstone National Park?

Where can …

Examining Rural-Urban Differences In Fatalism And Information Overload: Data From 12 Nci-Designated Cancer Centers, Jakob D Jensen, Jackilen Shannon, Ronaldo Iachan, Yangyang Deng, Sunny Jung Kim, Wendy Demark-Wahnefried, Babalola Faseru, Electra D Paskett, Jinxiang Hu, Robin C Vanderpool, Deann Lazovich, Jason A Mendoza, Sanjay Shete, Linda B Robertson, Rajesh Balkrishnan, Katherine J Briant, Benjamin Haaland, David A Haggstrom, Bernard F Fuemmeler, Rural Workgroup Of The Population Health Assessment In Cancer Center Catchment Areas Consortium

Faculty, Staff and Student Publications

BACKGROUND: Rural populations experience a disproportionate cancer burden relative to urban populations. One possibility is that rural populations are more likely to hold counterproductive cancer beliefs such as fatalism and information overload that undermine prevention and screening behaviors.

METHODS: Between 2016 and 2020, 12 U.S. cancer centers surveyed adults in their service areas using online and in-person survey instruments. Participants (

RESULTS: Compared with urban residents, rural residents were more likely to believe that (i) everything causes cancer (OR = 1.29; 95% CI, 1.17-1.43); (ii) prevention is not possible (OR = 1.34; 95% CI, 1.19-1.51); and (iii) there are too …

Randomized Phase Iii Bmt Ctn Trial Of Calcineurin Inhibitor-Free Chronic Graft-Versus-Host Disease Interventions In Myeloablative Hematopoietic Cell Transplantation For Hematologic Malignancies, Leo Luznik, Marcelo C Pasquini, Brent Logan, Robert J Soiffer, Juan Wu, Steven M Devine, Nancy Geller, Sergio Giralt, Helen E Heslop, Mary M Horowitz, Richard J Jones, Mark R Litzow, Adam Mendizabal, Lori Muffly, Eneida R Nemecek, Lynn O'Donnell, Richard J O'Reilly, Raquel Palencia, Johannes Schetelig, Leyla Shune, Scott R Solomon, Sumithira Vasu, Vincent T Ho, Miguel-Angel Perales

Faculty, Staff and Students Publications

PURPOSE: Calcineurin inhibitors (CNI) are standard components of graft-versus-host disease (GVHD) prophylaxis after hematopoietic cell transplantation (HCT). Prior data suggested that CNI-free approaches using donor T-cell depletion, either by ex vivo CD34 selection or in vivo post-transplant cyclophosphamide (PTCy) as a single agent, are associated with lower rates of chronic GVHD (cGVHD).

METHODS: This multicenter phase III trial randomly assigned patients with acute leukemia or myelodysplasia and an HLA-matched donor to receive CD34-selected peripheral blood stem cell, PTCy after a bone marrow (BM) graft, or tacrolimus and methotrexate after BM graft (control). The primary end point was cGVHD (moderate or …

Critical Perspectives On Our Current Moment: An Experiment In Teaching For 2020, Jane Eva Baxter Ph.D., Sarah Brown, Jenicel Carmona, Val Carnes, Zoe Espinosa, Randall Honold Ph.D., Cary Robbins, George Slad, Margaret Storey Ph.D.

Vincentian Studies

During the summer of 2020, the DePaul College of Liberal Arts and Social Sciences (LAS) offered twenty-two incoming students a special interdisciplinary online course, giving them the opportunity to learn and reflect on the crises of 2020 with faculty, staff, and one another. This article’s authors (who are the class’s faculty and students) describe the construction and execution of this course and reflect on the experience. Course topics included “the social contract; equity and justice; historical, cultural, and artistic responses to upheaval; global interconnections; and the way forward.” The course fulfilled DePaul’s mission to help students “engage questions of intellect …

Mass Incarceration, Covid-19, And Race As Exposure To Early Death, Traci Schlesinger Ph.D.

Vincentian Studies

A majority of the largest, single-site outbreaks of COVID-19 infections in the United States have been in prisons and jails since the beginning of the pandemic. These outbreaks threaten the lives and well-being of incarcerated people, correctional staff, and people who live in the communities to which incarcerated people return. This study employs both linear and logistic multivariate regression models to examine data from the UCLA’s COVID Prison Data Project, IPUMS CPS, the National Center for Health Statistics, and the Prison Policy Initiative to better understand the facility, county, and state-level predictors of COVID-19 infections and deaths in correctional facilities. …

Association Of A Longitudinal, Preclinical Ultrasound Curriculum With Medical Student Performance, David A. Haidar, Ross Kessler, Neil K. Khanna, Michael T. Cover, John C. Burkhardt, Nik Theyyunni, Ryan V. Tucker, Rob D. Huang, Elizabeth Holman, Patrick D. Bridge, Katherine A. Klein, Christopher M. Fung

Emergency Medicine Articles

INTRODUCTION: Point-of-care ultrasound (US) is used in clinical practice across many specialties. Ultrasound (US) curricula for medical students are increasingly common. Optimal timing, structure, and effect of ultrasound education during medical school remains poorly understood. This study aims to retrospectively determine the association between participation in a preclinical, longitudinal US curriculum and medical student academic performance.

METHODS: All first-year medical students at a medical school in the Midwest region of the United States were offered a voluntary longitudinal US curriculum. Participants were selected by random lottery. The curriculum consisted of five three-hour hands on-sessions with matching asynchronous content covering anatomy …

Revengence Taken: Russian Active Measures And Our Entrenched Racial Divide, Erin Berhan

University of Miami Race & Social Justice Law Review

Our racial divide has always been a national security threat. An early observer of our American project, Alexis de Tocqueville, wrote about this threat to our future union in “Democracy in America,” learned by merely travelling the young nation thirty years before our Civil War.1 Despite generations of societal and legal evolution, our nation has not overcome the wounds and disabilities that our racial divide left behind — now ripe for modern security threats. In 2019, the United States Senate Select Committee on Intelligence released Volume II of their years long investigation into Russian Active Measures of interference with our …

Coordinated Speech Therapy, Physiotherapy, And Pharmaceutical Care Telehealth For People With Parkinson Disease In Rural Communities: An Exploratory, 8-Week Cohort Study For Feasibility, Safety, And Signal Of Efficacy, Mary Jo Cooley Hidecker, Merrill R. Landers, Annalisa Piccorelli, Erin Bush, Reshmi Singh

Communication Sciences and Disorders Faculty Publications

Introduction: The potential for coordinated, multidisciplinary telehealth to help connect people with Parkinson disease (PD) in rural areas to PD specialists is crucial in optimizing care. Therefore, this study aimed to test the feasibility, safety, and signal of efficacy of a coordinated telehealth program, consisting of speech therapy, physiotherapy, and pharmaceutical care, for people with PD living in some rural US communities.

Methods: Fifteen individuals with PD living in rural Wyoming and Nevada, USA, participated in this single-cohort, 8-week pilot study. Participants were assessed before and after 8 weeks of coordinated, one-on-one telehealth using the following outcomes: (1) …

Diversity And Inclusion Or Tokens? A Qualitative Study Of Black Women Academic Nurse Leaders In The United States, Kechi Iheduru-Anderson, Florence O Okoro, Shawana S Moore

College of Nursing Faculty Papers & Presentations

Severe under-representation of Black women academic nurse leaders persists in United States higher education, and a major research gap still exists regarding experiences of these leaders, and facilitators of and barriers to their success. Our objective was to examine how race and gender influence how Black women academic nurse leaders’ function in their leadership positions, how they are perceived by their peers, and how their perception of race, gender, class, and power influences diversity, equity, and inclusion initiatives in the workplace. Critical race theory was used as a guiding theory, and the study design involved narrative inquiry followed by thematic …

On Controlling The Supreme Court: Is There A Future For American Law?, Bruce Ledewitz

Ledewitz Papers

Published scholarship collected from academic journals, law reviews, newspaper publications & online periodicals

Pilot Test Of A Quality Rating And Improvement System In Early Education Programs In Magadan Oblast, Rf, And In Minnesota, Usa, Elizabeth J. Sandell

Elementary and Literacy Education Department Publications

Quality in early childhood education matters. Scholarly research has demonstrated the critical importance of the first three years of a child’s life. The experiences and interactions children have in these early years significantly affects brain development and helps to establish the foundation for future learning. The topic of this study was to pilot test a Quality Rating and Improvement System (QRIS) in early education programs in Magadan, Russian Federation (RU) and in Mankato, Minnesota, United States of America (USA). The purpose of this study was to understand the use of a specific instrument to provide direction for the improvement of …

Barriers To Mental Health Care In The United States And Latin America, Eilis Reardon

CISLA Senior Integrative Projects

No abstract provided.

Polycentric Governance In Nebraska, U.S., For Ground And Surface Water, Theresa Jedd, Anthony B. Schutz, Mark Burbach

School of Natural Resources: Faculty Publications

This chapter describes the locally driven, but centrally coordinated, water governance model in Nebraska, U.S. It offers a snapshot of water resources and the importance of agriculture, then moves to the relevant political institutions in the state, and federal controls related to water quantity. The focus of the chapter is on the Nebraska Department of Natural Resources’ (NeDNR) and Natural Resources Districts’ (NRDs) management of surface and groundwater, which has some distinct and some overlapping authority. The main area of overlap is in addressing the connection between ground and surface water, particularly in situations when either or both are over …

Locating The Law : A Handbook For Non-Law Librarians, Elizabeth Caulfield, Southern California Association Of Law Libraries. Committee On Public Access To Legal Information.

AALL Legal Website of the Month

The Committee of the Southern California Association of Law Libraries (SCALL) made accessible a revised version of their comprehensive legal reference resource Locating the Law: A Handbook for Non-Law Librarians, 6th ed. The handbook provides ready access to a reliable legal research reference resource to assist you in reading legal citations and how to conduct legal research.

A Developing Italian Transnational Activism: Dialogues Between Italian Leftist Parties And American Political Organizations, 1935-1955, Matthew Daniel Halikias

Theses and Dissertations

This dissertation examines and explores through several case studies involving the political and intellectual significance of the development of a transnational dialogue between Italian leftist parties and American political organizations from the period before the Second World War to the Early Cold War period. An investigation of Girolamo Valenti and his actions with unions and labor-minded organizations demonstrates his activism with cultivating and establishing a strong relationship in the United States and Italy. This relationship materializes in the advocacy of relief for Italy after the Second World War, promoting for American involvements in Italian politics, and attempting to have an …

The Americanization Of A Swiss Immigrant: Interviews With Nicholas Von Rotz, Nicholas Von Rotz

Swiss American Historical Society Review

This interview was sponsored by the Association for Northern California Records and Research (as it was called at the time) at California State University, Chico, within the purview of its Oral History Program, called the Northeastern California Project. This association is now the Association for Northern California Historical Research and has granted permission for this interview to be republished by the Swiss American Historical Society.

On The Other Side Of The Tracks: Hannibal Square And Eatonville In The Interwar Years, Margaret Stewart

Honors Program Theses

The purpose of this study is to add nuance to the understanding of the Great Migration period, not only as a period of migration of North to South. The lives and migration of African Americans living in Hannibal Square and Eatonville highlight that African Americans were not just moving North. The Great Migration became more than a simple movement; it was a complex tapestry of African Americans moving where they felt the best opportunities were. This examination will stand within the bound of the early Great Migration period, from 1920 to 1940. The growth of each community will be analyzed …

What Alternative Models Are Effective In Improving Health Outcomes In Children With Obesity In The United States?, Kelsey Reineke

Theses and Graduate Projects

Background: Obesity in children has increased at an alarming rate in the past three decades and has been associated with multiple comorbidities. This literature review has been focused on pediatric obesity management research utilizing Family-Based Therapy, community-centered interventions, behavioral modifications, and implementations for management within the Primary Care setting.

Purpose: There has not been an established standard of care for children suffering from obesity. This investigation was focused on the question; What alternative models are effective in improving health outcomes in children with obesity in the United States?

Methods: A comprehensive literature review was conducted using Pub …

Examining Structural Racism As A Cause Of Health Inequities Among Pacific Island Peoples In The United States And Aotearoa New Zealand: An Exploratory Comparative Case Study, Jake Ryann Cambia Sumibcay

CGU Theses & Dissertations

Native Hawaiians and Pacific Islanders (NHPI) in the United States are known to experience profound and persistent disparities across most indicators of socioeconomic status and health when compared to the majority population. Similarly, the Indigenous Māori and Pacific peoples in Aotearoa New Zealand parallel the same experiences. Reducing disparities and improving health equity among racial/ethnic minority populations have been regarded as a national priority in both the United States and New Zealand. Improved population health data have provided insights into the social determinants of health (SDoH), which has unveiled multiple factors that contribute to health disparities, including income, education, residential …

Conjecture And Evidence: Discovering The Costs Of Contemporary American Political Ideals, Joseph C. Immormino

CGU Theses & Dissertations

This dissertation offers an adaptation of the relative political capacity (RPC) research framework to domestic American politics, enabling a quantitative examination of the relative performance of state governments during the COVID-19 pandemic. Theoretically, I examine the notion that more politically capable states will be more effective in their efforts to mitigate mortality rates, and hypothesize that, in the United States, such a relationship is conditional upon the party identification of state leadership. The premise is tested by applying a series of multiplicative interaction models to a unique dataset spanning the first two years of the pandemic. Results confirm that measures …

Ecmo: A Representative Descriptive Analysis Of 2018 Florida Billing Data, Robert F. Sparks

MUSC Theses and Dissertations

Since the inception of Extracorporeal Membrane Oxygenation (ECMO) in the early 1970’s, technological advances and increased understanding and implementation of ECMO protocols have produced exponentially better outcomes. With improved outcomes, use of ECMO has dramatically risen in the last several decades. The purpose of this study is to define the modalities of ECMO and their purposes, as well as potential complications and contraindications. Furthermore, research was conducted into determining important factors in patient outcomes such as patient characteristics, readmission rates, and success of the therapy. Patient data was scrutinized to determine if any categorical particularly affected the overall costs and …

Deep Graph Convolutional Network For Us Birth Data Harmonization, Lishan Yu, Hamisu M Salihu, Deepa Dongarwar, Luyao Chen, Xiaoqian Jiang

Faculty, Staff and Student Publications

In this paper, we developed a feasible and efficient deep-learning-based framework to combine the United States (US) natality data for the last five decades, with changing variables and factors, into a consistent database. We constructed a graph based on the property and elements of databases, including variables, and conducted a graph convolutional network (GCN) to learn the embeddings of variables on the constructed graph, where the learned embeddings implied the similarity of variables. Specifically, we devised a loss function with a slack margin and a banlist mechanism (for a random walk) to learn the desired structure (two nodes sharing more …

Factors Associated With Receiving Supplemental Nutrition Assistance Program (Snap) Among Newly Resettled Refugees In The United States, Edson Chipalo, Zainab Suntai, Simon Mwima

The Journal of Sociology & Social Welfare

In the United States, SNAP was made available to refugees in 1977, and most refugees rely heavily on SNAP to sustain themselves before becoming self-reliant. Knowledge of sociodemographic factors and chronic debilitating conditions related to receiving SNAP benefits among refugees is limited. This study aimed to examine sociodemographic factors and chronic debilitating conditions associated with receiving SNAP benefits among refugees resettled in the United States. This study used a cross-sectional, nationally representative sample (n=6,100) of the refugees who entered the U.S. between 2013 and 2017. The data were obtained from the 2018 Annual Survey of Refugees (ASR) from participants aged …

Constitutional Law—Penalizing The “Unsightly”: An Argument For The Abolishment Of Laws Criminalizing Life-Sustaining Behaviors Among The Homeless, Carli Ross

Western New England Law Review

Thousands of people across the country suffer from homelessness. Instead of funding more shelters or dealing with the lack of subsidized housing, cities have chosen to rely on the criminal justice system to regulate homeless behavior. Homeless individuals are being punished with fines and potential jail time for sleeping, sitting, gathering, and camping in public. Not only does this practice contribute to the homelessness crisis in the United States, but it also creates an additional obstacle for homeless individuals. Additionally, relying on the criminal justice system is more costly than helping homeless individuals find a permanent shelter. The Ninth Circuit …

Constitutional Law—Loyalty, Money, And Business: The New Price For A Presidential Pardon, Zachary J. Broughton

Western New England Law Review

The President of the United States, pursuant to Article II of the Constitution, has the sole power to issue pardons that free individuals of the confines and limitations of federal prosecution and conviction. In his only term as President so far, Donald Trump issued approximately 143 pardons. Several of those pardons were directed to those who attempted to interfere with the 2016 presidential election by way of lying to investigators and members of Congress and by tampering with evidence and witnesses. Many other pardons issued by President Trump were given only to those who had close ties to the Republican …

Imago Dei Interrupted : Christocentric Measures To Reintegrate American Women Into New Communities After Having Survived Commercial Sexual Exploitation, Timothy Peter Robbins

ATS Dissertations

No abstract provided.

Columbus State University Honors College: Senior Theses, Fall 2022/Spring 2023/Summer 2023, Les Anderson, Olympia Badwin, Ian Becerra, Lucy Clarke, Maya Davis, Kaylee Day, Dradley Defore, Rajvi Desai, Hannah Dickerson, Molly Foster, Andrew Holmes, Haley Johnson, Sana Khan, Nicole Kincaid, Kayleen Linge, Keenan Pasqua, Marc Pierre, Richard Rogers, Timothy Sabau, Kaitlyn Shepherd, Havahna Wilkes, Destinee Williams

Senior Theses from the Honors College

This is a collection of senior theses written by honors students at Columbus State University during the Fall 2022, Spring 2023, and Summer 2023 semesters.

Titles:

- "Mise En Scene: Healing Through a Cinematic Lense" , by Les Anderson

- "SCS22: Determining Molecular Function and Its Role in Heat Shock Protection in Saccharomyces Cerevisiae" , by Olympia Badwin

- "The Design and Activity of Novel Antimicrobial Hairpin Peptides" , Ian Becerra

- " Food Justice and Public Health: A Systematic Literature Review of Food Insecurity Prevalence among Black and Indigenous Populations Before and During COVID-19", by Maya Davis

- "The …

The Band Of American Ladies : Children’S Librarians And The Creation Of Children’S Literature In The Long 19th Century, Suzanne Stauffer

Faculty Publications

No abstract provided.