Digital Commons Network^™

The Performance Of Afp, Afp-3, Dcp As Biomarkers For Detection Of Hepatocellular Carcinoma (Hcc): A Phase 3 Biomarker Study In The United States, Nabihah Tayob, Fasiha Kanwal, Abeer Alsarraj, Ruben Hernaez, Hashem B El-Serag

Faculty, Staff and Students Publications

BACKGROUND & AIMS: α-fetoprotein (AFP), AFP Lens culinaris agglutinin-reactive fraction of AFP (AFP-L3), and des-gamma-carboxy prothrombin (DCP) in combination or in GALAD (Gender, Age, AFP-L3, AFP, and DCP) were tested for hepatocellular carcinoma (HCC) surveillance in retrospective cohort and case-control studies. However, there is a paucity of prospective data and no phase III biomarker studies from North American populations.

METHODS: We conducted a prospective specimen collection, retrospective blinded evaluation (PRoBE) cohort study in patients with cirrhosis enrolled in a 6-monthly surveillance with liver imaging and AFP. Blood samples were prospectively collected every 6 months and analyzed in a retrospective blinded …

Racial Injustice In Astrid Lindgren’S Kati In America, Irina I. Holden

University Libraries Faculty Scholarship

This article addresses Astrid Lindgren’s Kati in America, which was written in 1950 and translated into English in 1964. The novel reflects Lindgren’s impressions of the United States, where she traveled in 1948 on assignment for the publishing house Åhland and Åkerlund. By chance, the author of this article discovered that there is a fifteenth chapter of the book in the Russian, Polish, French, Spanish, and German translations, but which is missing in the English. This missing chapter describes the racism Lindgren’s protagonist witnesses during her visit to New Orleans. Astrid Lindgren’s depiction of racial injustice in the South …

Cost Of Failure To Achieve Textbook Outcomes: Association Of Insurance Type With Outcomes And Cumulative Cost For Inpatient Surgery, Michael A Jacobs, Jeongsoo Kim, Jasmine C Tetley, Susanne Schmidt, Bradley B Brimhall, Virginia Mika, Chen-Pin Wang, Laura S Manuel, Paul Damien, Paula K Shireman

Faculty, Staff and Student Publications

Background: Surgical outcome/cost analyses typically focus on single outcomes and do not include encounters beyond the index hospitalization.

Study design: This cohort study used NSQIP (2013-2019) data with electronic health record and cost data risk-adjusted for frailty, preoperative acute serious conditions (PASC), case status, and operative stress assessing cumulative costs of failure to achieve textbook outcomes defined as absence of 30-day Clavien-Dindo level III and IV complications, emergency department visits/observation stays (EDOS), and readmissions across insurance types (private, Medicare, Medicaid, uninsured). Return costs were defined as costs of all 30-day emergency department visits/observation stays and readmissions.

Results: Cases were performed …

Aapm Btsc Report 377: Physicist Brachytherapy Training In 2021-A Survey Of Therapeutic Medical Physics Residency Program Directors, Manik Aima, Samantha J Simiele, Susan L Richardson, Christopher S Melhus

Faculty, Staff and Student Publications

BACKGROUND: Brachytherapy (BT) was the first radiotherapeutic technique used to treat human disease and remains an essential modality in radiation oncology. A decline in the utilization of BT as a treatment modality has been observed and reported, which may impact training opportunities for medical physics residents. A survey of therapeutic medical physics residency program directors was performed as part of an assessment of the current state of BT training during residency.

METHODS: In March 2021, a survey consisting of 23 questions was designed by a working unit of the Brachytherapy Subcommittee of the American Association of Physicists in Medicine (AAPM) …

Adjuvant 5-Fluorouracil/Leucovorin, Capecitabine, And Oxaliplatin-Related Regimens For Stage Ii/Iii Colon Cancer Patients 66 Years Or Older, Emily Jones, Zhigang Duan, Thinh T Nguyen, Sharon H Giordano, Hui Zhao

Faculty, Staff and Student Publications

Adjuvant chemotherapy of leucovorin-modulated 5-fluorouracil (5-FU/LV), capecitabine, and adding oxaliplatin to 5-FU/LV or capecitabine (FLOX/OX) have been standard regimens for high-risk stage II or III colon cancer (CC). We aimed to evaluate their patterns of use, association with survival, and rate of emergency room visit (ER) or hospitalization during the treatment period. High-risk stage II or III patients aged >65 years diagnosed between 2007 and 2015, underwent colectomy, and received any of these three regimens were selected from SEER and Texas Cancer Registry (TC) linked with Medicare data. Chi-square test, Kaplan-Meier survival curves, Cox regression, and logistic regression were used …

Disparities In Mortality Among Acute Myeloid Leukemia-Related Hospitalizations, Sara Taveras Alam, Deepa Dongarwar, Elyse Lopez, Sarvari Yellapragada, Gustavo Rivero, Quillan Huang, Courtney Miler-Chism, Martha Mims, Hamisu M Salihu

Faculty, Staff and Student Publications

Racial and socioeconomic disparities have become apparent in acute myeloid leukemia (AML) outcomes. We conducted a retrospective cohort study of hospitalizations for adults with a diagnosis of AML from 2009 to 2018 in the Nationwide Inpatient Sample (NIS). We categorized patients' ages in groups of≥60 years and stratified them by reported race/ethnicity. Exposures of interest were patient sociodemographics, hospital characteristics, and Elixhauser-comorbidity Index. Outcome of interest was in-hospital death. Statistical analyses included survey logistic regression to generate adjusted odds ratios (aORs) and 95% confidence intervals (CIs) to quantify the independent associations between patient characteristics and mortality. Of 622,417 AML-related hospitalizations, …

Extremism In America: Explaining Variations In Ideologically Motivated Fatal Violence, Celinet Duran

Dissertations, Theses, and Capstone Projects

This dissertation uses data from the United States Extremist Crime Database (ECDB) to assess the nature of extremist violence between left-wing, far-right and al-Qaeda and associated movements (AQAM) inspired ideological fatal violence. It extends the empirical literature on extremist violence in three significant ways by: (1) expanding an existing database to provide a comparative component that is both timely and policy-relevant and conveys a more complete picture of the nature of domestic extremism in the U.S.; (2) systematically comparing extremist violence across the left-wing, far-right and AQAM ideologies to better assess the nuances of extremist violence; and (3) applying empirical …

Supreme Court Justice Brett Kavanaugh: 2023 Notre Dame Law Review Federal Courts Symposium, Marcus Cole, Brett Kavanaugh

2019–Present: G. Marcus Cole

Jan 26, 2023

NOTRE DAME LAW SCHOOL

U.S. Supreme Court Associate Justice Brett Kavanaugh covered a range of topics during a keynote Q&A at the 2023 Notre Dame Law Review Federal Courts Symposium, held on January 23 in the McCartan Courtroom. Justice Kavanaugh was joined by G. Marcus Cole, the Joseph A. Matson Dean and Professor of Law at Notre Dame Law School, and responded to questions from students and faculty members in the audience.

If I Were A Betting Man: Some Predictions For The Year We Have Left, Bruce Ledewitz

Newspaper Columns

Collected biweekly contributions to the Pennsylvania Capital-Star, a nonpartisan, nonprofit news site.

Comments On Advance Notice Of Proposed Rulemaking Regarding Resolution-Related Resource Requirements For Large Banking Organizations Of The Federal Reserve System And The Federal Deposit Insurance Corporation, First Republic Bank

Documents

No abstract provided.

Re: Comment Letter On The Advance Notice Of Proposed Rulemaking On Resolution-Related Resource Requirements For Large Banking Organizations Docket No. R–1786; Rin 7100–Ag44 (Board) 3064–Af86 (Fdic), Capital One, Charles Schwab, Pnc Financial Services Group, Truist Financial, U.S. Bancorp

Documents

No abstract provided.

Substrate Electronics Dominate The Rate Of Reductive Dehalogenation Promoted By The Flavin-Dependent Iodotyrosine Deiodinase, Jeffrey M Carlson, Ayzsa Tannis, Kate R Woodworth, Megan R Reynolds, Neha Shinde, Breanne Anderson, Keivon Hobeheidar, Aisha Praag, Kristen Campbell, Cynthia Carpentieri, Teri Willabus, Elizabeth Burkhardt, Elizabeth Torrone, Kevin P O'Callaghan, Kathryn Miele, Dana Meaney-Delman, Suzanne M Gilboa, Emily O'Malley Olsen, Van T Tong

Faculty, Staff and Student Publications

Despite universal prenatal syphilis screening recommendations and availability of effective antibiotic treatment, syphilis prevalence during pregnancy and the incidence of congenital syphilis have continued to increase in the United States (1,2). Concurrent increases in methamphetamine, injection drug, and heroin use have been described in women with syphilis (3). CDC used data on births that occurred during January 1, 2018-December 31, 2021, from two states (Arizona and Georgia) that participate in the Surveillance for Emerging Threats to Pregnant People and Infants Network (SET-NET) to describe the prevalence of substance use among pregnant persons with syphilis by congenital syphilis pregnancy outcome (defined …

Forgotten "People": Reviving Textualism In The Fourth Amendment, Peter C. Douglas

San Diego Law Review

For more than a century, the Supreme Court has struggled to develop a coherent and sustainable theory of the Fourth Amendment. Before the ink is dry on a new Fourth Amendment opinion, it is cabined, abrogated, or outright overruled. As one scholar has commented, the “evolution of Fourth Amendment doctrine over the past century bears a striking resemblance to Hamlet’s descent into insanity.” While the Court vacillates between “theories” of the Fourth Amendment that might bring clarity to a difficult body of constitutional law, the rights it bespeaks lie vulnerable and unprotected. This Article argues that the problem flows from …

Email Correspondence Between Vincient Arnold And The Ecb, Vincient Arnold, European Central Bank (Ecb)

Documents

No abstract provided.

Svb Q4 2022 Financial Highlights, Silicon Valley Bank

Documents

No abstract provided.

Fifty Years Of A National Program For The Treatment Of Kidney Failure, Kevin F Erickson, Melandrea Worsley, Wolfgang C Winkelmayer

Faculty, Staff and Students Publications

No abstract provided.

On Pope Benedict, Science, Faith, And His Legacy, Bruce Ledewitz

Newspaper Columns

Collected biweekly contributions to the Pennsylvania Capital-Star, a nonpartisan, nonprofit news site.

Trends And Racial/Ethnic Differences In Predictors Of Cervical Cancer Screening Among Us Women Ages 30-64 Years, Itunu O Sokale, Jane R Montealegre, Abiodun O Oluyomi, Aaron P Thrift

Faculty, Staff and Students Publications

BACKGROUND: Cervical cancer screening (CCS) participation has decreased in the United States over the last several decades, contributing to cervical cancer's sustained incidence and mortality. This study examined recent trends and racial/ethnic differences in predictors of CCS uptake among US women.

METHODS: We analyzed combined data from the 2016 to 2020 Behavioral Risk Factor Surveillance System (BRFSS) and included 235,713 women ages 30 to 64 years without a hysterectomy. We used simple linear regression to assess trends over time and multivariable logistic regression models to evaluate racial/ethnic differences in predictors of up-to-date CCS.

RESULTS: We found little change in CCS …

Family Income And Cardiovascular Disease Risk In American Adults, Abdul Mannan Khan Minhas, Vardhmaan Jain, Monica Li, Robert W Ariss, Marat Fudim, Erin D Michos, Salim S Virani, Laurence Sperling, Anurag Mehta

Faculty, Staff and Students Publications

Socioeconomic status is an overlooked risk factor for cardiovascular disease (CVD). Low family income is a measure of socioeconomic status and may portend greater CVD risk. Therefore, we assessed the association of family income with cardiovascular risk factor and disease burden in American adults. This retrospective analysis included data from participants aged ≥ 20 years from the National Health and Nutrition Examination Survey (NHANES) cycles between 2005 and 2018. Family income to poverty ratio (PIR) was calculated by dividing family (or individual) income by poverty guidelines specific to the survey year and used as a measure of socioeconomic status. The …

Investment Company Act Of 1940, United States Congress

Documents

No abstract provided.

Alcohol Consumption And Epigenetic Age Acceleration In Young Adults, Drew R Nannini, Lei Liu, Et Al.

2020-Current year OA Pubs

Alcohol is a widely consumed substance in the United States, however its effect on aging remains understudied. In this study of young adults, we examined whether cumulative alcohol consumption, i.e., alcohol years of beer, liquor, wine, and total alcohol, and recent binge drinking, were associated with four measures of age-related epigenetic changes via blood DNA methylation. A random subset of study participants in the Coronary Artery Risk Development in Young Adults Study underwent DNA methylation profiling using the Illumina MethylationEPIC Beadchip. Participants with alcohol consumption and methylation data at examination years 15 (

Examination Of Adverse Reactions After Covid-19 Vaccination Among Patients With A History Of Multisystem Inflammatory Syndrome In Children., Matthew D. Elias, Dongngan T. Truong, Matthew E. Oster, Felicia L. Trachtenberg, Xiangyu Mu, Pei-Ni Jone, Elizabeth C. Mitchell, Kirsten B. Dummer, S Kristen Sexson Tejtel, Onyekachukwu Osakwe, Deepika Thacker, Jennifer A. Su, Tamara T. Bradford, Kristin M. Burns, M Jay Campbell, Thomas J. Connors, Laura D'Addese, Daniel Forsha, Olivia H. Frosch, Therese M. Giglia, Lauren R. Goodell, Stephanie S. Handler, Keren Hasbani, Camden Hebson, Anita Krishnan, Sean M. Lang, Brian W. Mccrindle, Kimberly E. Mchugh, Lerraughn M. Morgan, R Mark Payne, Arash Sabati, Eyal Sagiv, Yamuna Sanil, Faridis Serrano, Jane W. Newburger, Audrey Dionne, Pediatric Heart Network Music Study Investigators

Manuscripts, Articles, Book Chapters and Other Papers

IMPORTANCE: Data are limited regarding adverse reactions after COVID-19 vaccination in patients with a history of multisystem inflammatory syndrome in children (MIS-C). The lack of vaccine safety data in this unique population may cause hesitancy and concern for many families and health care professionals.

OBJECTIVE: To describe adverse reactions following COVID-19 vaccination in patients with a history of MIS-C.

DESIGN, SETTING, AND PARTICIPANTS: In this multicenter cross-sectional study including 22 North American centers participating in a National Heart, Lung, and Blood Institute, National Institutes of Health-sponsored study, Long-Term Outcomes After the Multisystem Inflammatory Syndrome in Children (MUSIC), patients with a …

Large Variations In The Prices Of Urologic Procedures At Academic Medical Centers 1 Year After Implementation Of The Price Transparency Final Rule, Zeynep G Gul, Danielle R Sharbaugh, Cailey J Guercio, Daniel L Pelzman, Cameron A Jones, Emily C Hacker, Vivian I Anyaeche, Levi Bowers, Ashti M Shah, Michael G Stencel, Jonathan G Yabes, Bruce L Jacobs, Benjamin J Davies

2020-Current year OA Pubs

IMPORTANCE: Patients with urologic diseases often experience financial toxicity, defined as high levels of financial burden and concern, after receiving care. The Price Transparency Final Rule, which requires hospitals to disclose both the commercial and cash prices for at least 300 services, was implemented to facilitate price shopping, decrease price dispersion, and lower health care costs.

OBJECTIVE: To evaluate compliance with the Price Transparency Final Rule and to quantify variations in the price of urologic procedures among academic hospitals and by insurance class.

DESIGN, SETTING, AND PARTICIPANTS: This was a cross-sectional study that determined the prices of 5 common urologic …

Haitian Immigrants' Information Needs And Behaviors: Libraries, Information Professionals And Haitians In The United States, Natasha Finnegan

School of Information Student Research Journal

Haitian immigrants are a socially excluded growing demographic in the United States that deals with racism, anti-immigrant sentiment, anti-Haiti rhetoric, and language barriers. Information professionals need to understand Haitian information behavior, their cultural preferences, and barriers in order to successfully fulfill their information needs. This article examines other disciplines’ relevant and scholarly research literature on Haitian immigrants in the United States to discover their trends of information behavior and barriers so that the Library and Information Science field can create effective information pathways to support their community. Haitian immigrants turn to their families and trusted individuals for their information needs, …

An Alternative To The Independent State Legislature Doctrine, Bruce Ledewitz

Ledewitz Papers

Published scholarship collected from academic journals, law reviews, newspaper publications & online periodicals

The Openness Of Talmud, Bruce Ledewitz

Ledewitz Papers

Published scholarship collected from academic journals, law reviews, newspaper publications & online periodicals.

Machine Learning Algorithms Improve Modis Gpp Estimates In United States Croplands, D. Menefee, T. O. Lee, K. C. Flynn, J. Chen, M. Abraha, J. Baker, A. Suyker

School of Natural Resources: Faculty Publications

No abstract provided.

Institute For Public Policy & Civic Engagement Nationwide Survey, Institute For Public Policy & Civic Engagement

Public Policy Poll Results

The Sacred Heart University Institute for Public Policy & Civic Engagement leveraged a quantitative research approach to address the following areas of investigation:

• Awareness of Healthcare Sustainability, Corporate Sustainability, Environmental Sustainability, Sustainable Education, and Social Justice
• Personal alignment with Sacred Heart University’s definition for each sustainability concept
• Perceived importance and benefit of each sustainability concept
• Perceived impact on society and the community
• Demographic profile of respondents

Crafting U.S. Foreign Policy Towards China Through Congress: An Examination Of Arlen Specter & Congressional Delegations To China, Gabriel C. Kelly

Arlen Specter Center Research Fellowship

Scholars and policy analysts are currently engaged in an ongoing debate about what the United States’ relationship with the People’s Republic of China will be.[1] According to international relations scholar Bruce W. Jentleson, the People’s Republic of China (PRC) has, “…the world’s second largest economy… the third largest amount [of military spending] in the world, [and is] the world’s most populous country.”[2] Perspectives on the U.S. relationship with the PRC range from “confrontation” to “cooperation,”[3] and congressional representatives can potentially shape this debate on China through congressional delegation trips. Congressional delegation trips are an underexamined phenomenon in …

Puerto Ricans In The United States 2021, Center For Puerto Rican Studies

CUNY Centro, The Center for Puerto Rican Studies

No abstract provided.