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American And Brazilian Children With Primary Urolithiasis: Similarities And Disparities., Maria Goretti Moreira Guimarães Penido, Marcelo De Sousa Tavares, Milena Maria Moreira Guimarães, Tarak Srivastava, Uri S. Alon Jan 2014

American And Brazilian Children With Primary Urolithiasis: Similarities And Disparities., Maria Goretti Moreira Guimarães Penido, Marcelo De Sousa Tavares, Milena Maria Moreira Guimarães, Tarak Srivastava, Uri S. Alon

Manuscripts, Articles, Book Chapters and Other Papers

Objectives. Considering the differences in location, socioeconomic background, and cultural background, the aim of this study was to try to identify possible factors associated with the increased incidence of urolithiasis by comparing American and Brazilian children with stones.
Methods. Data of 222 American and 190 Brazilian children with urolithiasis were reviewed including age, gender, body mass index, imaging technique used (ultrasound and computed tomography), and 24-hour urine volume and chemistries.
Results. There were no differences between age and gender at diagnosis. Brazilian children were leaner but in no population did obesity rate exceed that of the general population. Ultrasound was …


Allocating Responsibility For Health Care Decisions Under The United States Affordable Care Act, Wendy K. Mariner Jan 2014

Allocating Responsibility For Health Care Decisions Under The United States Affordable Care Act, Wendy K. Mariner

Faculty Scholarship

This article summarizes the major elements of the ACA's insurance reforms and how they affect responsibility for making decisions about the health care that people receive. A key example of the difficulty of allocating decision making responsibility is the effort to define a minimum benefit package for insurance plans, called essential health benefits. While the ACA should achieve its goal of near-universal access to care, it leaves in place a multiplicity of processes and decision-makers for determining individual treatment. As a result, decisions about what care is provided are likely to remain, much as they are today, divided among government …


Students' Perspectives Of Ngo Service-Learning Experiences: A Case Study Of Operation Smile, Suzanne B. Unger, Shana Pribesh, Linda Bol, Daniel Dickerson Jan 2014

Students' Perspectives Of Ngo Service-Learning Experiences: A Case Study Of Operation Smile, Suzanne B. Unger, Shana Pribesh, Linda Bol, Daniel Dickerson

Educational Leadership & Workforce Development Faculty Publications

Past research demonstrated both strong and questionable benefits to students participating in domestic service-learning. However, we know little about high school and college students' perspectives of service-learning while working with nonprofit, non-governmental (NGO) agencies that serve international populations. This qualitative, exploratory study aims to determine how students perceive their lives are impacted as a result of their service-learning experiences at Operation Smile. Data were collected from two focus groups comprised of high school and university youth. Results indicated service-learning in an international setting positively influences areas of personal growth, career choice, and future philanthropic participation. It also affects level of …


Student Debt And Declining Retirement Savings, William Elliott, Michal Grinstein-Weiss, Ilsung Nam Nov 2013

Student Debt And Declining Retirement Savings, William Elliott, Michal Grinstein-Weiss, Ilsung Nam

Center for Social Development Research

In this study, the authors use the Survey of Consumer Finances (SCF) to determine whether student loan debt is associated with retirement savings. They find that the median 2009 retirement savings amount for households with no outstanding student loan debt ($55,000) is nearly twice as high as it is for households with outstanding student loan debt ($25,000). Further, multivariate statistics indicate that a household with a four-year college graduate, outstanding student loan debt, and median retirement savings ($80,983) in 2007 incurred a loss of 52% of those retirement savings in 2009 contrasted with household with a similar household with no …


Is Student Debt Compromising Homeownership As A Wealth-Building Tool?, William Elliott, Michal Grinstein-Weiss, Ilsung Nam Nov 2013

Is Student Debt Compromising Homeownership As A Wealth-Building Tool?, William Elliott, Michal Grinstein-Weiss, Ilsung Nam

Center for Social Development Research

In this study, the authors use 2007–2009 Survey of Consumer Finance longitudinal data to examine if having student loans affected home equity during the Great Recession. We find that median 2009 home equity ($90,000) for households with no outstanding student loan debt is twice as high as that of households with outstanding student loan debt ($45,000). Further, multivariate statistics reveal that a household with a college graduate, median 2007 home equity, and student loan debt had $54,334 (40%) less home equity in 2009 than a household with a college graduate, median home equity, and no college debt. The main policy …


Recommendations For High-Priority Research On Cancer-Related Fatigue In Children And Adults., Andrea M. Barsevick, Michael R. Irwin, Pamela Hinds, Andrew Miller, Ann Berger, Paul Jacobsen, Sonia Ancoli-Israel, Bryce B Reeve, Karen Mustian, Ann O'Mara, Jin-Shei Lai, Michael Fisch, David Cella Oct 2013

Recommendations For High-Priority Research On Cancer-Related Fatigue In Children And Adults., Andrea M. Barsevick, Michael R. Irwin, Pamela Hinds, Andrew Miller, Ann Berger, Paul Jacobsen, Sonia Ancoli-Israel, Bryce B Reeve, Karen Mustian, Ann O'Mara, Jin-Shei Lai, Michael Fisch, David Cella

Department of Medical Oncology Faculty Papers

Over the past decades, some scientific progress has been made in understanding and treating cancer-related fatigue (CRF). However, three major problems have limited further progress: lack of agreement about measurement, inadequate understanding of the underlying biology, and problems in the conduct of clinical trials for CRF. This commentary reports the recommendations of a National Cancer Institute Clinical Trials Planning Meeting and an ongoing National Cancer Institute working group to address these problems so that high-priority research and clinical trials can be conducted to advance the science of CRF and its treatment. Recommendations to address measurement issues included revising the current …


Clinical Inertia In Type 2 Diabetes: A Retrospective Analysis Of Pharmacist-Managed Diabetes Care Vs. Usual Medical Care, Felix K. Yam, Aimee G. Adams, Holly Divine, Douglas Steinke, Mikael D. Jones Oct 2013

Clinical Inertia In Type 2 Diabetes: A Retrospective Analysis Of Pharmacist-Managed Diabetes Care Vs. Usual Medical Care, Felix K. Yam, Aimee G. Adams, Holly Divine, Douglas Steinke, Mikael D. Jones

Pharmacy Practice and Science Faculty Publications

Background: Evidence suggests that patients with type 2 diabetes (T2DM) suffer from a high rate of “clinical inertia” or “recognition of the problem but failure to act.”

Objective: The aim of this study is to quantify the rate of clinical inertia between two models of care: Pharmacist-Managed Diabetes Clinic (PMDC) vs. Usual Medical Care (UMC).

Methods: Patients in a university based medical clinic with type 2 diabetes (T2DM) were analyzed in this retrospective cohort study. Patients were exposed to either PMDC or UMC. The difference in days to intervention in response to suboptimal laboratory values and time …


Seed For Oklahoma Kids: Experimental Test Of A Policy Innovation In A Full Population, Lisa Reyes Mason, Yunju Nam, Margaret Clancy, Michael Sherraden Oct 2013

Seed For Oklahoma Kids: Experimental Test Of A Policy Innovation In A Full Population, Lisa Reyes Mason, Yunju Nam, Margaret Clancy, Michael Sherraden

Center for Social Development Research

The Center for Social Development at Washington University in St. Louis has implemented an ambitious policy demonstration: SEED for Oklahoma Kids (SEED OK). This initiative uses multiple research methods, including a scientific experiment in a full population, to test a policy innovation. The innovation is providing a Child Development Account (CDA) to all children at birth. In SEED OK, randomly selected newborn children in Oklahoma received a college savings account “seeded” with a $1,000 initial deposit, plus additional components of the SEED OK intervention. This case study describes the multiyear process of designing and implementing SEED OK and sheds light …


A Comparison Of Growth Rates In Premature Infants In Tucamàn, Argentina And The United States: A Secondary Data Analysis, Emily Sear, Joann Abegglen Sep 2013

A Comparison Of Growth Rates In Premature Infants In Tucamàn, Argentina And The United States: A Secondary Data Analysis, Emily Sear, Joann Abegglen

Journal of Undergraduate Research

Extrauterine growth, or growth outside the womb following birth, is a serious challenge and concern in premature neonates. Preterm infants have low birth weights simply because they have not reached full growth and development at the time of birth.


Population Cancer Risks Associated With Coal Mining: A Systematic Review, Wiley D. Jenkins, W. Jay Christian, Georgia Mueller, K. Thomas Robbins Jul 2013

Population Cancer Risks Associated With Coal Mining: A Systematic Review, Wiley D. Jenkins, W. Jay Christian, Georgia Mueller, K. Thomas Robbins

Epidemiology and Environmental Health Faculty Publications

BACKGROUND: Coal is produced across 25 states and provides 42% of US energy. With production expected to increase 7.6% by 2035, proximate populations remain at risk of exposure to carcinogenic coal products such as silica dust and organic compounds. It is unclear if population exposure is associated with increased risk, or even which cancers have been studied in this regard.

METHODS: We performed a systematic review of English-language manuscripts published since 1980 to determine if coal mining exposure was associated with increased cancer risk (incidence and mortality).

RESULTS: Of 34 studies identified, 27 studied coal mining as an occupational exposure …


Assessment Of The Dining Environment On And Near The Campuses Of Fifteen Post-Secondary Institutions, Tanya M. Horacek, Maria B. Erdman, Carol Byrd-Bredbenner, Gale Carey, Sarah E. Colby, Geoffrey W Greene, Wen Guo, Kendra Kattelmann, Melissa D. Olfert, Jennifer Walsh, Adrienne A. White Jul 2013

Assessment Of The Dining Environment On And Near The Campuses Of Fifteen Post-Secondary Institutions, Tanya M. Horacek, Maria B. Erdman, Carol Byrd-Bredbenner, Gale Carey, Sarah E. Colby, Geoffrey W Greene, Wen Guo, Kendra Kattelmann, Melissa D. Olfert, Jennifer Walsh, Adrienne A. White

Health and Nutritional Sciences Faculty Publications

OBJECTIVE: The present study evaluated the restaurant and dining venues on and near post-secondary campuses varying in institution size.
DESIGN: The Nutrition Environment Measures Survey for Restaurants (NEMS-R) was modified to evaluate restaurants as fast food, sit down and fast casual; and campus dining venues as dining halls, student unions and snack bar/cafe´s. ANOVA with post hoc Tukey’s B and T tests were used to distinguish differences between dining venues and associated institutions by size.
SETTING: The study was conducted at fifteen US post-secondary institutions, 2009–2011.
SUBJECTS: Data presented are from a sample of 175 restaurants and sixty-eight on-campus dining …


In-Depth Interviews With State Public Health Practitioners On The United States National Physical Activity Plan, Kelly R Evenson, Sara B Satinsky, Cheryl Valko, Jeanette Gustat, Isobel Healy, Jill S Litt, Steven P Hooker, Hannah L Reed, Nancy Tompkins Jan 2013

In-Depth Interviews With State Public Health Practitioners On The United States National Physical Activity Plan, Kelly R Evenson, Sara B Satinsky, Cheryl Valko, Jeanette Gustat, Isobel Healy, Jill S Litt, Steven P Hooker, Hannah L Reed, Nancy Tompkins

Faculty & Staff Scholarship

No abstract provided.


Investigating Barriers To Celiac Disease Diagnosis And Patient Wellbeing In The U.S. : A Comparative Study Of The United States And Italy, Medelaine Dickinson Jan 2013

Investigating Barriers To Celiac Disease Diagnosis And Patient Wellbeing In The U.S. : A Comparative Study Of The United States And Italy, Medelaine Dickinson

Honors Capstones

This study compared awareness of and attitudes toward celiac disease (CD) among American and Italian medical professionals, patients, and the general public in order to better understand and identify barriers to celiac disease diagnosis and patient wellbeing in the United States. Although the U.S. prevalence of the disease is somewhat higher than in Italy, the rate of diagnosis in the United States is significantly lower. One of the biggest differences between the two countries is awareness level (Guandalini, 2012 & Fasano, 2001). Factors that impact awareness are an important topic for study because of the strong relationship between awareness level …


Identifying Environmental Health Priorities In Underserved Populations: A Study Of Rural Versus Urban Communities, M. C. Bernhard, M. B. Evans, S. T. Kent, E. Johnson, S. L. Threadgill, S. M. Becker Jan 2013

Identifying Environmental Health Priorities In Underserved Populations: A Study Of Rural Versus Urban Communities, M. C. Bernhard, M. B. Evans, S. T. Kent, E. Johnson, S. L. Threadgill, S. M. Becker

Community & Environmental Health Faculty Publications

Objectives- Understanding and effectively addressing persistent health disparities in minority communities requires a clear picture of members' concerns and priorities. This study was intended to engage residents in urban and rural communities in order to identify environmental health priorities. Specific emphasis was placed on how the communities: defined the term environment; their perceptions of environmental exposures as affecting their health; specific priorities in their communities; and differences in urban versus rural populations.

Study design- A community-engaged approach was used to develop and implement focus groups and compare environmental health priorities in urban versus rural communities.

Methods- A total of eight …


Daughters Of Charity: Women, Religious Mission, And Hospital Care In Los Angeles, 1856-1927, Kristine Ashton Gunnell Jan 2013

Daughters Of Charity: Women, Religious Mission, And Hospital Care In Los Angeles, 1856-1927, Kristine Ashton Gunnell

Vincentian Digital Books

A captivating story, culled from extensive historical research, documents how ingenuity, determination, and faith enabled mission-driven Daughters of Charity to establish, develop, and provide healthcare in Los Angeles. This work contains multiple examples of their flexibility to overcome barriers of culture, religion, language, and scarce resources in the context of frontier politics but without comprise of their faith-based mission of service to persons in need.


Untangling Cultural Differences In Behavioral, Physiological, And Psychological Symptoms Of Dementia And Alzheimer’S Disease, John S. Avant Jan 2013

Untangling Cultural Differences In Behavioral, Physiological, And Psychological Symptoms Of Dementia And Alzheimer’S Disease, John S. Avant

Calvert Undergraduate Research Awards

According to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR; 4th ed. Revised; American Psychiatric Association) and (BPSD) there are many behavioral, physiological, and psychological issues that have been correlated with the progression of the Alzheimer’s disease and other dementias. Examples of these issues include; emotional regulation problems, variations in eating behavior, and an advancing decline in memory. Though certain symptoms of the disease seem to be widely universal, current literature shows that a number of disparities do exist. There are several differences between and within populations suffering from Alzheimer’s disease and dementia that are influenced by various …


Elevated Cardiovascular Risk Among Adults With Obstructive And Restrictive Airway Functioning In The United States: A Cross-Sectional Study Of The National Health And Nutrition Examination Survey From 2007-2010, Earl S. Ford, Anne G. Wheaton, David M. Mannino, Letitia Presley-Cantrell, Chaoyang Li, Janet B. Croft Dec 2012

Elevated Cardiovascular Risk Among Adults With Obstructive And Restrictive Airway Functioning In The United States: A Cross-Sectional Study Of The National Health And Nutrition Examination Survey From 2007-2010, Earl S. Ford, Anne G. Wheaton, David M. Mannino, Letitia Presley-Cantrell, Chaoyang Li, Janet B. Croft

Preventive Medicine and Environmental Health Faculty Publications

BACKGROUND: Reasons for the excess risk for cardiovascular disease among people with chronic obstructive pulmonary disease remain unclear. Our objective was to examine the cardiovascular risk profile for adults with obstructive and restrictive impairments of lung functioning in a representative sample of adults from the United States.

METHODS: We used data from adults aged 20-79 years who participated in the National Health and Nutrition Examination Survey from 2007 to 2010 and had a pulmonary function test. The severity of obstructive impairment was defined by adapting the Global Initiative for Chronic Obstructive Lung Disease criteria.

RESULTS: Among 7249 participants, 80.9% had …


Technology Transfer Laws Governing Federally Funded Research And Development, James V. Lacy, Bradford C. Brown, Michael R. Rubin Nov 2012

Technology Transfer Laws Governing Federally Funded Research And Development, James V. Lacy, Bradford C. Brown, Michael R. Rubin

Pepperdine Law Review

No abstract provided.


Lowther, Charles Ernest, B. 1951 (Sc 649), Manuscripts & Folklife Archives Jun 2012

Lowther, Charles Ernest, B. 1951 (Sc 649), Manuscripts & Folklife Archives

Manuscript Collection Finding Aids

Finding aid and scan (Click on "additional files" below) for Manuscripts Small Collection 649. Photocopies of letters written to Charles Ernest Lowther, of Nortonville, Kentucky, and a history student at Western Kentucky University, from various members of the U.S. Congress in reply to Lowther’s letter regarding the Nixon-Cox incident.


Early Childhood Special Education In Norway And The United States: A Meta-Synthesis, Julia Brainerd Jun 2012

Early Childhood Special Education In Norway And The United States: A Meta-Synthesis, Julia Brainerd

Special Education Masters Program Theses

This meta-synthesis investigates various aspects of early childhood special education in Norway and the U.S. Both countries strive to provide services for young children with disabilities in inclusive settings. However, the differences in policy, levels of governmental regulation and involvement, local organization of service delivery, and provision of social benefits shape very different realities for children with disabilities, their families, and their service providers in Norway and the U.S. This inquiry of 43 articles addresses such issues as overall quality of services and support available to children with disabilities and their families, qualifications of personnel who work with children with …


Socioeconomic Factors That Lead To Latino Male Students Leaving School Before Graduating, Joseph C. D'Agostino May 2012

Socioeconomic Factors That Lead To Latino Male Students Leaving School Before Graduating, Joseph C. D'Agostino

Education

Students of color make up a predominant number of learners that leave high school before graduating (National Center for Education Research, 2009). I selected to study Latino males to narrow the scope of my research. The literature I reviewed pointed directly at socioeconomics as one of the primary factors. I feel there are more specific factors involved for many of the individuals impacted. I used a qualitative approach and utilized an anonymous survey and individual interviews to pinpoint some of these factors. The findings from my research further supported that socioeconomics were a leading factor. My data and literature review …


Grandparents, Great Parents: Negotiating The Role Transition To Custodial Grandparent, Leanne Alaine Burnett May 2012

Grandparents, Great Parents: Negotiating The Role Transition To Custodial Grandparent, Leanne Alaine Burnett

Communication

An ever increasing number of grandparents in the United States are taking on the responsibility for providing primary care for their grandchildren. Focus group interviews conducted in two urban communities in Alaska were the basis of this study examining how grandparents negotiate the role transition as they become custodial grandparents. Role theory was used to inform the analysis of the data. The two major themes which emerged suggested these transitions were effected by role conflict and role timing. The grandparents participating in the study indicated that involvement in peer support groups helped them to more successfully negotiate this difficult role …


Quality Improvement Of Diabetic Care At A Resident Clinic, Carmi Santos Punzalan, Md, Sarah Rutherford, Md, Andrew Lerner, Md, Tasha Kouvatsos, Md, Sneha Thakkar, Md, Melissa Klein, Md, David Manoff, Md, Cecilia Kelly, Md, Dina Halegoua, Md, Gregory Kane, Md May 2012

Quality Improvement Of Diabetic Care At A Resident Clinic, Carmi Santos Punzalan, Md, Sarah Rutherford, Md, Andrew Lerner, Md, Tasha Kouvatsos, Md, Sneha Thakkar, Md, Melissa Klein, Md, David Manoff, Md, Cecilia Kelly, Md, Dina Halegoua, Md, Gregory Kane, Md

The Medicine Forum

Our objective was to develop a quality improvement project on diabetes mellitus at our internal medicine residency clinic. Residents developed projects aimed at improving an aspect of diabetic care. Continuity of care, achievement of clinical targets, no-show rates, patient knowledge of diabetes, and preventive care were evaluated. Our data was obtained with a questionnaire and a retrospective review of medical records. A different provider was scheduled about every 1.78 visit. The no-show rate was 25.4%. About half of patients identified goal hgbA1c and BPs, and 35% and 60% achieved their hgbA1c and SBP goals respectively. Nearly all of the charts …


Persistent Severe Hyperkalemia In A Patient With Normal Renal Function, Michael L. Tobin, Md May 2012

Persistent Severe Hyperkalemia In A Patient With Normal Renal Function, Michael L. Tobin, Md

The Medicine Forum

Case Report

A 75-year-old female with a past medical history significant for hypertension, hyperlipidemia, and colon cancer, status post colectomy with ileostomy, presented to the Methodist Hospital emergency room with muscular low back pain, which began a few hours prior, after abruptly bending over. Upon arrival to the hospital, she had no other complaints and noted that the back pain was starting to resolve without intervention.

In triage, her heart rate was measured at 38 beats per minute (BPM) with her other vital signs within normal limits. Her electrocardiogram (EKG) was read as a junctional rhythm with a rate of …


Not Your Typical Case Of Ascites: Pancreatic Ascites In A Patient With Cirrhosis And Pancreatic Duct Leak, Philip Montemuro, Md, Abhik Roy, Md May 2012

Not Your Typical Case Of Ascites: Pancreatic Ascites In A Patient With Cirrhosis And Pancreatic Duct Leak, Philip Montemuro, Md, Abhik Roy, Md

The Medicine Forum

Case

A 55-year-old male with a history of hepatic cirrhosis secondary to Hepatitis C and alcohol abuse presented to an outside hospital with progressive abdominal pain and distension. The patient initially complained of “punching” right upper quadrant and epigastric abdominal pain that was 10/10 in intensity and non-radiating. Although the pain had started one to two days prior to presentation, the patient had been experiencing several weeks of increasing abdominal distension. He reported drinking eight 40oz beers daily for over 40 years, and he felt that the abdominal pain improved slightly with cessation of alcohol use. The patient complained of …


Mother Knows Best: The Rhetorical Persona Of Michelle Obama And The "Let's Move" Campaign, Monika Bertaki May 2012

Mother Knows Best: The Rhetorical Persona Of Michelle Obama And The "Let's Move" Campaign, Monika Bertaki

UNLV Theses, Dissertations, Professional Papers, and Capstones

Some first ladies are often condemned for being too involved with the presidents' power in politics while other first ladies find themselves condemned for the lack of involvement. First ladies, it seems, are damned if they do and damned if they don't. Consequently, Michelle Obama faces rhetorical problems that in some respects are similar to those of previous first ladies and in other respects are quite different. Along with the criticisms encountered by previous presidential wives, Obama faces the stereotypes African American women have endured since the inception of the nation. Michelle Obama's "Let's Move" campaign serves as a rhetorical …


Demographics Of Entrants: Sisters Of Charity Of St. Joseph’S, 1809–1849 And Daughters Of Charity, Province Of The United States, 1850–1909, Betty Ann Mcneil D.C. Apr 2012

Demographics Of Entrants: Sisters Of Charity Of St. Joseph’S, 1809–1849 And Daughters Of Charity, Province Of The United States, 1850–1909, Betty Ann Mcneil D.C.

Vincentian Studies

A project began in 2002 to develop a database tracking all the admissions to the Sisters of Charity of Saint Joseph’s (1809–1849) and the Daughters of Charity (1850–1909) in the United States. This article explains how the project was conducted, what sources were used, and what the study’s major findings were. The database encompassed many different demographics: family backgrounds, birthplaces, and age of entrants, their marital and/or convert status, their years of entrance, and whether they had relatives in the community. Military service, withdrawals, transfers, separations, and burial places were also tracked.


Beyond Bailouts: Federal Tools For Preventing State Budget Crises, Brian D. Galle, Kirk J. Stark Apr 2012

Beyond Bailouts: Federal Tools For Preventing State Budget Crises, Brian D. Galle, Kirk J. Stark

Indiana Law Journal

More than two years after the official end of the Great Recession, state governments still face significant budget deficits that cannot be addressed without further drastic spending cuts or substantial revenue increases. The structural origins of the ongoing state fiscal crisis are well known. Excessively procyclical revenue structures, combined with spending obligations that increase with economic downturns, have resulted in a budget dynamic for the states that is not sustainable over the long term. The consensus solution to this problem is for states to save money during boom times (via budget stabilization or “rainy day” funds) and to draw on …


Framing The College Debate : Insights On Obama's Rhetoric Through The Capabilities Approach, Caitlin M. Manak Apr 2012

Framing The College Debate : Insights On Obama's Rhetoric Through The Capabilities Approach, Caitlin M. Manak

Honors Theses

President Obama has proposed that the United States increase the number of college graduates by 8 million by 2020 in order to raise national educational standards and to engage in global competition. Obama’s policies and rhetoric frequently describe “education as a pathway to success” and “education as a pathway to jobs,” but fail to emphasize its comprehensive, intrinsic values. America’s national discussion on education needs to shift away from framing higher education merely as pathway to the workforce, and should focus instead on education as a vital part of a well-lived life. To fulfill social justice under the capabilities approach, …


Fibrinogen, Chronic Obstructive Pulmonary Disease (Copd) And Outcomes In Two United States Cohorts, Deepa Valvi, David M. Mannino, Hana Müllerova, Ruth Tal-Singer Mar 2012

Fibrinogen, Chronic Obstructive Pulmonary Disease (Copd) And Outcomes In Two United States Cohorts, Deepa Valvi, David M. Mannino, Hana Müllerova, Ruth Tal-Singer

Preventive Medicine and Environmental Health Faculty Publications

BACKGROUND: Fibrinogen is a marker of systemic inflammation and may be important in the pathogenesis and progression of chronic obstructive pulmonary disease (COPD).

METHODS: We used baseline data from Atherosclerosis Risk in Communities and Cardiovascular Health Studies to determine the relation between fibrinogen levels and COPD and to examine how fibrinogen levels at baseline affected outcomes of death, development of COPD, lung function decline, and COPD-hospitalizations.

RESULTS: Our study sample included 20,192 subjects, of whom 2995 died during the follow-up period. The mean fibrinogen level was 307.6 mg/dL and 10% of the sample had levels >393.0 mg/dL. Subjects with Stage …