Digital Commons Network^™

Contemporary Homozygous Familial Hypercholesterolemia In The United States: Insights From The Cascade Fh Registry, Marina Cuchel, Paul C. Lee, Lisa C. Hudgins, P. Barton Duell, Zahid Ahmad, Seth J. Baum, Macrae F. Linton, Sarah D. De Ferranti, Christie M. Ballantyne, John A. Larry, Linda C. Hemphill, Iris Kindt, Samuel S. Gidding, Seth S. Martin, Patrick M. Moriarty, Paul P. Thompson, James A. Underberg, John R. Guyton, Rolf L. Andersen, David J. Whellan, Irwin Benuck, John P. Kane, Kelly Myers, William Howard, David Staszak, Allison Jamison, Mary C. Card, Mafalda Bourbon, Joana R. Chora, Daniel J. Rader, Joshua W. Knowles, Katherine Wilemon, Mary P. Mcgowan

Division of Cardiology Faculty Papers

Background

Homozygous familial hypercholesterolemia (HoFH) is a rare, treatment‐resistant disorder characterized by early‐onset atherosclerotic and aortic valvular cardiovascular disease if left untreated. Contemporary information on HoFH in the United States is lacking, and the extent of underdiagnosis and undertreatment is uncertain.

Methods and Results

Data were analyzed from 67 children and adults with clinically diagnosed HoFH from the CASCADE (Cascade Screening for Awareness and Detection) FH Registry. Genetic diagnosis was confirmed in 43 patients. We used the clinical characteristics of genetically confirmed patients with HoFH to query the Family Heart Database, a US anonymized payer health database, to estimate the …

A Geospatial Approach To Identify Patterns Of Antibiotic Susceptibility At A Neighborhood Level In Wisconsin, United States, Laurel Legenza, Kyle Mcnair, Song Gao, James P Lacy, Brooke J Olson, Thomas R Fritsche, Lucas T Schulz, Samantha Lamuro, Frances Spray-Larson, Tahmeena Siddiqui, Warren E Rose

Faculty, Staff and Student Publications

The global threat of antimicrobial resistance (AMR) varies regionally. This study explores whether geospatial analysis and data visualization methods detect both clinically and statistically significant variations in antibiotic susceptibility rates at a neighborhood level. This observational multicenter geospatial study collected 10 years of patient-level antibiotic susceptibility data and patient addresses from three regionally distinct Wisconsin health systems (UW Health, Fort HealthCare, Marshfield Clinic Health System [MCHS]). We included the initial Escherichia coli isolate per patient per year per sample source with a patient address in Wisconsin (N = 100,176). Isolates from U.S. Census Block Groups with less than 30 isolates …

State-Level Macro-Economic Factors Moderate The Association Of Low Income With Brain Structure And Mental Health In U.S. Children, David G Weissman, Mark L Hatzenbuehler, Mina Cikara, Deanna M Barch, Katie A Mclaughlin

2020-Current year OA Pubs

Macrostructural characteristics, such as cost of living and state-level anti-poverty programs relate to the magnitude of socioeconomic disparities in brain development and mental health. In this study we leveraged data from the Adolescent Brain and Cognitive Development (ABCD) study from 10,633 9-11 year old youth (5115 female) across 17 states. Lower income was associated with smaller hippocampal volume and higher internalizing psychopathology. These associations were stronger in states with higher cost of living. However, in high cost of living states that provide more generous cash benefits for low-income families, socioeconomic disparities in hippocampal volume were reduced by 34%, such that …

Pornography Use Among Young Adults In The United States, Samantha Smith, Jamie Lesueur

Ballard Brief

Pornography exists in many forms across the internet including pictures, videos, audio, written materials, video games, and social media posts. A majority of the US population has intentionally viewed pornography before, with an even larger majority of US young adults viewing pornography regularly. Despite the widespread use of and support for pornography, viewing sexually explicit media can have many negative consequences. For example, pornography use has been shown to correlate with decreased sex-life satisfaction, lack of positive self-image, and increased chances of divorce. Research also shows that both pornography viewers and pornography actors are likely to experience emotional health consequences. …

Heterogeneity Of Treatment Effects Of Hydrocortisone By Risk Of Bronchopulmonary Dysplasia Or Death Among Extremely Preterm Infants In The National Institute Of Child Health And Human Development Neonatal Research Network Trial: A Secondary Analysis Of A Randomized Clinical Trial, Samuel J. Gentle, Matthew A. Rysavy, Lei Li, Matthew M. Laughon, Ravi M. Patel, Erik A. Jensen, Susan Hintz, Namasivayam Ambalavanan, Waldemar A. Carlo, Kristi Watterberg, National Institute Of Child Health And Human Development Neonatal Research Network

Pediatrics Research and Scholarship

IMPORTANCE: Extremely preterm infants who develop bronchopulmonary dysplasia (BPD) are at a higher risk for adverse pulmonary and neurodevelopmental outcomes. In the National Institute of Child Health and Human Development Neonatal Research Network (NICHD NRN) Hydrocortisone Trial, hydrocortisone neither reduced rates of BPD or death nor increased rates of neurodevelopmental impairment (NDI) or death.

OBJECTIVE: To determine whether estimated risk for grades 2 to 3 BPD or death is associated with the effect of hydrocortisone on the composite outcomes of (1) grades 2 to 3 BPD or death and (2) moderate or severe NDI or death.

DESIGN, SETTING, AND PARTICIPANTS: …

Consumers' Perceptions Of Digital Privacy In The United States And Japan, Destiny Randle

Whittier Scholars Program

The purpose of my study is to explore the contours of contemporary consumer privacy protections derived from legislation, regulations and publicly available company policies as a way to get a better understanding of how consumer data is protected. A few examples ranging from company-based consumer protection in the United States to data breaches in Japan will be explored and examined. Finally, this paper includes a comparative survey of consumer perceptions and concerns related to personal data privacy in the U.S. and Japan. As a way to assess the degree to which digital privacy and personal data breaches have adversely influenced …

A Scoping Review Of The Impact Of Solitary Confinement On Self-Harm And Suicide Among Adults In U.S. Prisons, Jessica Diana Puebla

Social Work Theses - Archive

Solitary confinement is a widespread issue that impacts the most vulnerable individuals in our country. The U.S. uses solitary confinement more frequently and for longer periods of time compared to other countries though its use has not proven to be an effective intervention in prisons. Solitary confinement limits the individual’s ability to connect with peers, friends, and family as visits are restricted, thus impacting their mental health. This thesis aimed to understand the impact of solitary confinement of self-harm and suicide among adults in U.S. prisons; This thesis also attempted to shed light on the theoretical lenses that were stated …

Lonergan’S Concept Of Conversion: A Path To Antiracism, Laura Boysen-Aragon

Say Something Theological: The Student Journal of Theological Studies

Racism is Christian America’s original sin. Our country’s foundation was built with the hands of more than ten million kidnapped and enslaved persons. The Catholic Church was complicit as enslavers and beneficiaries of enslaved labor as well as the marginalizing of Black Catholics. Given the limited attention that has been given to these origin stories in our country and our church, it is unsurprising that systems of racism perpetuate today. Catholic theologian and ethicist Bryan Massingale provides a definition of racism as an ethos that lives on in U.S. society. Since the murder of George Floyd, a heightened awareness of …

Difference In Smoking Patterns And Quitting Status Between Premium And Non-Premium Cigar Users After Two Years Of Follow Up In Us Adults: Findings From The Population Assessment Of Tobacco And Health (Path) Study, 2016-2019, Sarah Valencia

Dissertations and Theses (Open Access)

Previous studies have described the demographics, purchasing behaviors, trends in frequencies of cigar use, and quitting status among cigar poly users, however, there has not been a study that evaluates differences in demographic characteristics and quitting status for premium and non-premium U.S. adult cigar users. This study used secondary data analyses of the Population Assessment of Tobacco and Health (PATH) Study public-use files dataset for adult traditional cigar users in wave 4 (2016-2018) and wave 5 (2018-2019). Traditional cigars were classified as premium or non-premium at wave 4 (2016-2018) using the brand and price per stick of cigar that was …

A Protocol For A Cluster Randomized Trial Of Care Delivery Models To Improve The Quality Of Smoking Cessation And Shared Decision Making For Lung Cancer Screening, Lisa M Lowenstein, Ya-Chen Tina Shih, Jennifer Minnix, Maria A Lopez-Olivo, Kristin G Maki, George Kypriotakis, Viola B Leal, Sanjay S Shete, James Fox, Shawn P Nishi, Paul M Cinciripini, Robert J Volk

Faculty, Staff and Student Publications

BACKGROUND: Patients eligible for lung cancer screening (LCS) are those at high risk of lung cancer due to their smoking histories and age. While screening for LCS is effective in lowering lung cancer mortality, primary care providers are challenged to meet beneficiary eligibility for LCS from the Centers for Medicare & Medicaid Services, including a patient counseling and shared decision-making (SDM) visit with the use of patient decision aid(s) prior to screening.

METHODS: We will use an effectiveness-implementation type I hybrid design to: 1) identify effective, scalable smoking cessation counseling and SDM interventions that are consistent with recommendations, can be …

Population Genetics Among Rhipicephalus Sanguineus Ticks In The Lower Rio Grande Valley, Bianca Liana Guerra

Theses and Dissertations

Rhipicephalus sanguineus is a common tick species in the lower Rio Grande Valley of both human and veterinary concern. Two lineages of R. sanguineus have been described across the United States known as the tropical and temperate lineage. Both lineages can be differentiated morphologically, genetically, biologically, and by vector competence. The species name for both lineages has not been well established therefore this thesis will utilize their widely used identification. Both lineages have been identified in Texas. While the distribution of these lineages has been well-defined in some regions across the world, recent studies have observed sympatric populations in certain …

From “Cowardice” To “Shellshock”: The Definition And Treatment Of Mental Health In The United States Marine Corps During The Age Of The Great War, Itzel Marquez

Theses and Dissertations

The aim of my master’s thesis is to study how the United States’ Marine Corps recognized, defined, and treated mental health issues during the Great War and how this translated into the treatment of Marines by their peers and commanding officers. Similar to other countries that fought in the Great War, also referred to as World War I, the United States witnessed intense discussions about the psychological effects of war. The question of whether and how modern warfare affected troops’ mental health was addressed by all branches of the United States’ military. Yet, the issue of mental health in the …

Successes And Failures Of War And The Shifting Landscape: An Analysis Of The Dynamic Relationship Between The Elements Of The Clausewitzian Trinity, Hannah Crosby

Senior Honors Theses

In his writing On War, Carl von Clausewitz explained the nonlinear nature of war and the inevitable chaos that occurs during times of conflict. Fundamental to his theory of war is the Clausewitzian Trinity, comprised of three elements: the people, the military, and the government. In the text, he emphasized the intrinsic relationship of these variables, observing that political objectives are the original motives for war. As such, the inherent values of the people will have a direct impact on the success of any war. In an examination of various military conflicts since the time of World War II, …

Childhood Obesity In The United States, Emma Stohl

Ballard Brief

Childhood obesity has been a problem in the United States for decades. The rate of childhood obesity has tripled since the 1970s. As of 2023, 1 in 5 children in the US are obese, with this number rising yearly. Childhood obesity is exacerbated by the lifestyle of children, where their attention is consumed by technology use at the expense of consuming nutritious foods and participating in physical activities. The lack of physical education in schools influences children’s health education and is partly responsible for childhood obesity. Genetics also play a role in childhood obesity depending on the characteristics of a …

Impacts Of Climate Change In The United States, Nathan Thompson

Ballard Brief

While every country both contributes to and feels the effects of climate change, the United States' heavy influence and high rates of contribution make this problem even more acute domestically. Climate change is primarily driven by human emission of greenhouse gases through the burning of fossil fuels and from mass-scale agriculture. Because climate change can be a polarizing issue, passing legislation to slow the harmful contributing factors has proven difficult. The effects of climate change have worsened in the past few decades, with increased instances of wildfires and extreme shifts in weather patterns. These negative consequences disproportionately affect vulnerable people …

The Underreporting And Dismissal Of Sexual Assault Cases Against Women In The United States, Jacey Passmore

Ballard Brief

Sexual assault is a highly prevalent yet rarely addressed issue within the United States. It is considered the most underreported and dismissed crime. There are a plethora of variables contributing to the underreporting and dismissal of sexual assault cases. The most prevalent factor appears to be the various understandings of sexual assault. The United States has no standard definition of rape or consent due to rape myths, victim blaming, disproportionately high perceptions of baseless allegations, and high-profile cases that are unrepresentative of the more common details of sexual assault. Other major contributing factors include knowing the perpetrator, victims’ pre-existing and …

An Exploration Of Online Doctoral Students And The Ways They Cultivate Connections, Shannon Reynolds

Theses and Dissertations

According to the United States Department of Education, 42.4% of postbaccalaureate students participated in online distance education during Fall of 2019. These numbers increased because of the Covid-19 pandemic of March 2020. The pandemic not only created a severe social and economic disruption, but it also disrupted all levels of education. This study examines exclusively online students enrolled with traditional face-to-face students and faculty. Understanding the impact of the pandemic, faculty and administrators can gain insights into how online learning can be adapted to meet the unique needs of advanced learners. The pandemic has forced many universities to move their …

The Social Vulnerability Index As A Risk Stratification Tool For Health Disparity Research In Cancer Patients: A Scoping Review, Tiffaney Tran, Morgan A Rousseau, David P Farris, Cici Bauer, Kelly C Nelson, Hung Q Doan

Faculty, Staff and Student Publications

PURPOSE: The social vulnerability index (SVI), developed by the Centers for Disease Control and Prevention, is a novel composite measure encompassing multiple variables that correspond to key social determinants of health. The objective of this review was to investigate innovative applications of the SVI to oncology research and to employ the framework of the cancer care continuum to elucidate further research opportunities.

METHODS: A systematic search for relevant articles was performed in five databases from inception to 13 May 2022. Included studies applied the SVI to analyze outcomes in cancer patients. Study characteristics, patent populations, data sources, and outcomes were …

Chronic Overlapping Pain Conditions And Long-Term Opioid Treatment, Maria Ukhanova, Robert W Voss, Miguel Marino, Nathalie Huguet, Steffani R Bailey, Daniel M Hartung, Jean O'Malley, Irina Chamine, John Muench

Faculty, Staff and Student Publications

OBJECTIVES: One in 5 people in the United States lives with chronic pain. Many patients with chronic pain experience a subset of specific co-occurring pain conditions that may share a common pain mechanism and that have been designated as chronic overlapping pain conditions (COPCs). Little is known about chronic opioid prescribing patterns among patients with COPCs in primary care settings, especially among socioeconomically vulnerable patients. This study aims to evaluate opioid prescribing among patients with COPCs in US community health centers and to identify individual COPCs and their combinations that are associated with long-term opioid treatment (LOT).

STUDY DESIGN: Retrospective …

What Is The Importance Of Social Work Involvement In Hospice Care Transitions For Ill Children And Their Families, Natalie Rodas, Guillermina Morales

Electronic Theses, Projects, and Dissertations

Thousands of children who face terminal illnesses die annually in the United States, 10% of those children and their families have hospice care services available. Through this study, the importance of social work involvement in hospice care transitions for ill children and their families were examined. Due to the scarcity of social work in hospice care settings, this study helped amplify research on the importance of social workers in hospice care for ill children and their families. The study consisted of individual interviews held via Zoom with medical social workers that have experience working in pediatric hospice care. The individual …

Refugee Advocacy Organizations: Factors That Influence Success In The United States And Ireland, Caleb Elkington-Stauss

Accounting Undergraduate Honors Theses

This thesis is a comparative study of refugee advocacy organizations in Ireland and in the United States. The goal is to research and study some of the best practices that refugee support organizations utilize and report how these two countries address the ever-growing refugee crisis. This study assesses the applications and operations in both organizations and determines how these practices contribute to the fulfillment of their missions. This better understanding of the strengths and struggles experienced by these organizations will support the development of a model and framework for successful social welfare initiatives. Within this thesis, the social initiatives in …

Comprehensive Literature Review: Assessing The Impact Of Covid-19 Policies, School Closures And Social Distancing, On The Mental Health Of School Age Children, Fatuma A. Hassan

Capstone Experience: Master of Public Health

Mental health is vital to the well-being of all individuals, especially children. COVID-19 unveiled a significant public health issue with poor mental health during the pandemic. There is limited literature about the mental health implications of COVID-19 policies for children and adolescents and preventive strategies for future pandemics. This comprehensive literature review seeks to further investigate the mental health impacts of school shutdowns and social distancing, which were nonpharmaceutical strategies, on school-aged children, 5-18 years old, and propose recommendations for public health officials to mitigate the mental health impacts for future pandemics. Additionally, the review aims to highlight the potential …

The Effects Of Natural Epigenetic Therapies In 3d Ovarian Cancer And Patient-Derived Tumor Explants: New Avenues In Regulating The Cancer Secretome, Aya Mohr-Sasson, Jigal Haas, Michal Sivan, Yoni Zehori, Rina Hemi, Raoul Orvieto, Arnon Afek, Jaron Rabinovici

Faculty, Staff and Student Publications

KEY MESSAGE: Menstruation of adolescent girls might be influenced by Covid-19 mRNA vaccine, however, the ovarian reserve estimated by AMH is not compromised.

BACKGROUND: Recent studies have suggested that the acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine causes menstrual abnormalities which led to concerns regarding its influence on the reproductive system. This study aims to investigate the influence of the SARS-CoV-2 mRNA vaccine on gynecologic well-being and future fertility of adolescent girls.

METHODS: This is a prospective cohort study conducted at a university affiliated medical center between June and July 2021. Adolescent girls aged 12-16 years who were vaccinated …

Secondary Validation Of An Ovarian Cancer-Specific Comorbidity Index In A Us Population, Chelsey Vranes, Hui Zhao, Mette Calundann Noer, Shuangshuang Fu, Charlotte C Sun, Ross Harrison, Pedro T Ramirez, Claus Kim Høgdall, Sharon H Giordano, Larissa A Meyer

Faculty, Staff and Student Publications

Objectives: The Ovarian Cancer Comorbidity Index (OCCI) is an age-specific index developed and previously found to be more predictive of overall and cancer-specific survival than the Charlson Comorbidity Index (CCI). The objective was to perform secondary validation of the OCCI in a US population.

Methods: A cohort of ovarian cancer patients undergoing primary or interval cytoreductive surgery from January 2005 to January 2012 was identified in SEER-Medicare. OCCI scores were calculated with the regression coefficients determined from the original developmental cohort for five comorbidities. Cox regression analyses were used to calculate associations between the OCCI risk groups and 5-year overall …

Critical Review Of Oncologic Medical Malpractice Claims Against Orthopaedic Surgeons, William Davis, Shravya Kichena, Michael D Eckhoff, Benjamin R Childs, Rajiv Rajani, Matthew E Wells, Sean P Kelly

Faculty, Staff and Student Publications

INTRODUCTION: The purpose of this study was to determine the most common allegations for malpractice litigation brought against orthopaedic surgeons for oncologic matters and the resulting verdicts.

METHODS: The Westlaw Legal research database was queried for malpractice cases filed against orthopaedic surgeons for oncologic matters in the United States after 1980. Plaintiff demographics, state of filing, allegations, and outcomes of lawsuits were recorded and reported accordingly.

RESULTS: A total of 36 cases met the inclusion and exclusion criteria and were subsequently included in the final analysis. The overall rate of cases filed remained consistent through the past four decades and …

Heterogeneity Of Treatment Effects Of Hydrocortisone By Risk Of Bronchopulmonary Dysplasia Or Death Among Extremely Preterm Infants In The National Institute Of Child Health And Human Development Neonatal Research Network Trial: A Secondary Analysis Of A Randomized Clinical Trial, Samuel J Gentle, Matthew A Rysavy, Lei Li, Matthew M Laughon, Ravi M Patel, Erik A Jensen, Susan Hintz, Namasivayam Ambalavanan, Waldemar A Carlo, Kristi Watterberg, National Institute Of Child Health And Human Development Neonatal Research Network

Faculty, Staff and Student Publications

IMPORTANCE: Extremely preterm infants who develop bronchopulmonary dysplasia (BPD) are at a higher risk for adverse pulmonary and neurodevelopmental outcomes. In the National Institute of Child Health and Human Development Neonatal Research Network (NICHD NRN) Hydrocortisone Trial, hydrocortisone neither reduced rates of BPD or death nor increased rates of neurodevelopmental impairment (NDI) or death.

OBJECTIVE: To determine whether estimated risk for grades 2 to 3 BPD or death is associated with the effect of hydrocortisone on the composite outcomes of (1) grades 2 to 3 BPD or death and (2) moderate or severe NDI or death.

DESIGN, SETTING, AND PARTICIPANTS: …

Association Of Cumulative Colorectal Surgery Hospital Costs, Readmissions, And Emergency Department/Observation Stays With Insurance Type, Michael A Jacobs, Jasmine C Tetley, Jeongsoo Kim, Susanne Schmidt, Bradley B Brimhall, Virginia Mika, Chen-Pin Wang, Laura S Manuel, Paul Damien, Paula K Shireman

Faculty, Staff and Student Publications

Background/purpose: Medicare's Hospital Readmission Reduction Program disproportionately penalizes safety-net hospitals (SNH) caring for vulnerable populations. This study assessed the association of insurance type with 30-day emergency department visits/observation stays (EDOS), readmissions, and cumulative costs in colorectal surgery patients.

Methods: Retrospective inpatient cohort study using the National Surgical Quality Improvement Program (2013-2019) with cost data in a SNH. The odds of EDOS and readmissions and cumulative variable (index hospitalization and all 30-day EDOS and readmissions) costs were modeled adjusting for frailty, case status, presence of a stoma, and open versus laparoscopic surgery.

Results: The cohort had 245 private, 195 Medicare, and …

Gender Bias In Antidepressant Direct-To-Consumer Pharmaceutical Advertising, Leila K Asadi, Asim A Shah

Faculty, Staff and Students Publications

Background: Direct to consumer pharmaceutical advertising (DTCPA) may have significant impacts on public perception of diseases and treatments. Our objective was to examine whether DTCPA for antidepressants disproportionately portray and hence target women in the United States.

Methods: DTCPA for branded medications for depression, psoriasis and diabetes were analyzed to determine the gender of the main "patient" portrayed, as well as the content of the disease depiction.

Results: DTCPA for antidepressants included only women in 82% of ads, only men in 10.1% of ads, and both genders in 7.8% of ads. There were significantly higher representations of women versus men …

Impact Of The 2018 Unos Heart Transplant Policy Changes On Patient Outcomes, Neil S Maitra, Samuel J Dugger, Isabel C Balachandran, Andrew B Civitello, Prateeti Khazanie, Joseph G Rogers

Faculty, Staff and Students Publications

In 2018, the United Network for Organ Sharing implemented a 6-tier allocation policy to replace the prior 3-tier system. Given increasing listings of critically ill candidates for heart transplantation and lengthening waitlist times, the new policy aimed to better stratify candidates by waitlist mortality, shorten waiting times for high priority candidates, add objective criteria for common cardiac conditions, and further broaden sharing of donor hearts. There have been significant shifts in cardiac transplantation practices and patient outcomes following the implementation of the new policy, including changes in listing practices, waitlist time and mortality, transplant donor characteristics, post-transplantation outcomes, and mechanical …

Commentary: Sponsoring Scholarship: Mountains Moved By The American Association For Thoracic Surger, Bryan M Burt

Faculty, Staff and Students Publications

No abstract provided.