Digital Commons Network^™

Area Deprivation Index And Segregation On The Risk Of Hiv: A Us Veteran Case-Control Study, Abiodun O Oluyomi, Angela L Mazul, Yongquan Dong, Donna L White, Christine M Hartman, Peter Richardson, Wenyaw Chan, Jose M Garcia, Jennifer R Kramer, Elizabeth Chiao

Faculty, Staff and Student Publications

BACKGROUND: Preventing HIV infection remains a critically important tool in the continuing fight against HIV/AIDS. The primary aim is to evaluate the effect and interactions between a composite area-level social determinants of health measure and an area-level measure of residential segregation on the risk of HIV/AIDS in U.S. Veterans.

METHODS: Using the individual-level patient data from the U.S. Department of Veterans Affairs, we constructed a case-control study of veterans living with HIV/AIDS (VLWH) and age-, sex assigned at birth- and index date-matched controls. We geocoded patient's residential address to ascertain their neighborhood and linked their information to two measures of …

Plasma Metabolites Associated With Cognitive Function Across Race/Ethnicities Affirming The Importance Of Healthy Nutrition, Einat Granot-Hershkovitz, Shan He, Jan Bressler, Bing Yu, Wassim Tarraf, Casey M Rebholz, Jianwen Cai, Queenie Chan, Tanya P Garcia, Thomas Mosley, Bruce S Kristal, Charles Decarli, Myriam Fornage, Guo-Chong Chen, Qibin Qi, Robert Kaplan, Hector M González, Tamar Sofer

Faculty, Staff and Student Publications

INTRODUCTION: We studied the replication and generalization of previously identified metabolites potentially associated with global cognitive function in multiple race/ethnicities and assessed the contribution of diet to these associations.

METHODS: We tested metabolite-cognitive function associations in U.S.A. Hispanic/Latino adults (n = 2222) from the Community Health Study/ Study of Latinos (HCHS/SOL) and in European (n = 1365) and African (n = 478) Americans from the Atherosclerosis Risk In Communities (ARIC) Study. We applied Mendelian Randomization (MR) analyses to assess causal associations between the metabolites and cognitive function and between Mediterranean diet and cognitive function.

RESULTS: Six metabolites were consistently associated …

Considerations When Designing And Implementing Pragmatic Clinical Trials That Include Older Hispanics, Rafael Samper-Ternent, Stephanie L Silveira, Alan Stevens, Elena Volpi, Aanand D Naik

Faculty, Staff and Student Publications

Introduction: Pragmatic clinical trials (PCTs) are designed to connect researchers with clinicians to assess the real-world effectiveness and feasibility of interventions, treatments, or health care delivery strategies in routine practice. Within PCTs larger, more representative sampling is possible to improve the external validity of the research. Older adults from underrepresented groups can benefit from PCTs given their historically lower engagement in clinical research. The current article focuses on older Hispanic adults with Alzheimer disease and related dementias (ADRDs). Older Hispanic adults represent 19% of the US population and have a higher prevalence of ADRDs than Whites. We provide data from …

The Association Of Smoking And Coffee Consumption With Occurrence Of Upper Gastrointestinal Symptoms In Patients With Active Helicobacter Pylori Infection In Jazan City: A Cross-Sectional Study, Anna Palatnik, Paula Mcgee, Jennifer L Bailit, Ronald J Wapner, Michael W Varner, John M Thorp, Steve N Caritis, Mona Prasad, Alan T N Tita, George R Saade, Dwight J Rouse, Sean C Blackwell, Eunice Kennedy Shriver National Institute Of Child Health And Human Development Maternal-Fetal Medicine Units (Mfmu) Networ

Faculty, Staff and Student Publications

Objective:

To examine whether there are racial disparities in severe maternal morbidity in patients with hypertensive disorder of pregnancy (HDP).

Study Design:

Secondary analysis of an observational study of 115,502 patients who had a live birth at ≥ 20 weeks in 25 hospitals in the US from 2008 to 2011. Only patients with HDP were included in this analysis. Race and ethnicity were categorized as non-Hispanic White, non-Hispanic Black and Hispanic and were abstracted from the medical charts. Patients of other races and ethnicities were excluded. Associations were estimated between race and ethnicity and the primary outcome of severe maternal …

“It Looks Like The Future But Feels Like The Past”: Oral (Hi)Stories Of Appalachia As Covid-19 News Stories, Ashley Reid Mcgraw

Theses and Dissertations

Oral historians have often felt obligated to collect stories during disasters and crises, to preserve recollections of experiences and trauma of those affected. During the onset of COVID-19 in the United States, this surge was certainly present. Appalachia, although its boundaries are contested, has a strong association with oral histories, and thus was the focus of one project in particular: a collaboration with the Blue Ridge Public Radio and the Foxfire Appalachian Heritage Museum to collect, curate, publish, and broadcast oral histories of "local" individuals. But what does it mean to be local, in a region as broad as Appalachia? …

Exercise And Mental Health Over The Course Of A Semester, Jamie Alexis Whitney

Theses and Dissertations

Introduction and purpose: Anxiety and depression are two of the most common mental health struggles in the United States each year. There has been promising research noting the positive effects of exercise on lowering symptoms of both anxiety and depression. Anxiety and depression are highly prevalent on college campuses, especially during high stress portions of the semester. The purpose of this study was to observe the changes in mental health over the course of the semester and if exercise level mediated any of these changes in the university population. Methods: Participants scanned a QR code or followed a link to …

Overall Survival Associated With Cdk4/6 Inhibitors In Patients With Hr+/Her2- Metastatic Breast Cancer In The United States: A Seer-Medicare Population-Based Study, Ravi K Goyal, Hua Chen, Susan M Abughosh, Holly M Holmes, Sean D Candrilli, Michael L Johnson

Faculty, Staff and Student Publications

Background: Evidence on overall survival (OS) with cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors is generally limited to data from clinical trials or a few observational studies with limited generalizability to Medicare population. The aim of this study was to determine OS benefits associated with CDK4/6 inhibitors in older Medicare patients with hormone receptor (HR)-positive and human epidermal growth factor receptor-2 overexpressing (HER2-) metastatic breast cancer (MBC).

Methods: In a retrospective cohort design, female patients aged ≥65 years with diagnosis of HR+/HER2- MBC from 2015 to 2017 who initiated first-line systemic therapy within 12 months of MBC diagnosis were selected …

Paving The Road For Chimeric Antigen Receptor T Cells: American Society For Transplantation And Cellular Therapy 80/20 Task Force Consensus On Challenges And Solutions To Improving Efficiency Of Clinical Center Certification And Maintenance Of Operations For Commercially Approved Immune Effector Cell Therapies, Sarah Nikiforow, Matthew J Frigault, Noelle V Frey, Rebecca A Gardner, Krishna V Komanduri, Miguel-Angel Perales, Partow Kebriaei, Phyllis Irene Warkentin, Marcelo Pasquini, Joy Lynn Aho, Bruce L Levine, Helen E Heslop, Tracey L Hlucky, Karen Habucky, Mecide Gharibo, Madan Jagasia, Frederick L Locke

Faculty, Staff and Students Publications

As the number and type of regulatory authority-approved cellular therapies grow, clinical treatment centers face a heavy burden of duplicative documentation around initial qualification, ongoing auditing, and reporting, with overlapping requirements from each manufacturer to ensure safe use of their specific product, which in the United States are stipulated under individual Food and Drug Administration (FDA) Biologic License Applications. The American Society for Transplantation and Cellular Therapy (ASTCT) convened the 80/20 Task Force to consider challenges and potential solutions to these issues. The Task Force proposed that 80% of manufacturers' requirements for onboarding and ongoing operations of commercially available products …

Why Schwab, A Financial Giant, Got Hurt In The Regional Banks Panic, Tara Siegel Bernard

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No abstract provided.

Fact Sheet: President Biden Urges Regulators To Reverse Trump Administration Weakening Of Common-Sense Safeguards And Supervision For Large Regional Banks, United States: The White House: Biden Administration

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Metropolitan Commercial Bank Issues Updated Financial Information, Metropolitan Commercial Bank

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Jamie Dimon Reprises 2008 Role As Rescuer Of A Failing Bank, Rob Copeland, Maureen Farrell

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Dear Pandemic: A Topic Modeling Analysis Of Covid-19 Information Needs Among Readers Of An Online Science Communication Campaign., Aleksandra M Golos, Sharath Chandra Guntuku, Rachael Piltch-Loeb, Lindsey J Leininger, Amanda M Simanek, Aparna Kumar, Sandra S Albrecht, Jennifer Beam Dowd, Malia Jones, Alison M Buttenheim

College of Nursing Faculty Papers & Presentations

BACKGROUND: The COVID-19 pandemic was accompanied by an "infodemic"-an overwhelming excess of accurate, inaccurate, and uncertain information. The social media-based science communication campaign Dear Pandemic was established to address the COVID-19 infodemic, in part by soliciting submissions from readers to an online question box. Our study characterized the information needs of Dear Pandemic's readers by identifying themes and longitudinal trends among question box submissions.

METHODS: We conducted a retrospective analysis of questions submitted from August 24, 2020, to August 24, 2021. We used Latent Dirichlet Allocation topic modeling to identify 25 topics among the submissions, then used thematic analysis to …

Hearing Entitled: The Federal Regulators' Response To Recent Bank Failures, Gop Financial Services

Video

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The Federal Regulators' Response To Recent Bank Failures: Hearing Before The Committee On Financial Services: U.S. House Of Representatives: One Hundred Eighteenth Congress First Session, United States Government

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Recent Bank Failures And The Federal Regulatory Response: Hearing Before The Committee On Banking, Housing, And Urban Affairs: United States Senate: One Hundred Eighteenth Congress First Session On Examining The Recent U.S. Bank Failures And The Federal Regulators' Response, United States Government

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First Citizens Bank Announces Acquisition Of Silicon Valley Bridge Bank, N.A, First Citizens Bancshares

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Lessons From Applying The Liquidity Coverage Ratio To Silicon Valley Bank, Greg Feldberg

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The Fed’S Recent Bank Stress Tests Used Scenarios With Little Variation. None Examined Higher Interest Rates, Patrick Honohan

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First Citizens Bank Announces Acquisition Of Silicon Valley Bridge Bank, N.A., First Citizens Bank

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First–Citizens Bank & Trust Company, Raleigh, Nc, To Assume All Deposits And Loans Of Silicon Valley Bridge Bank, N.A., From The Fdic, Federal Deposit Insurance Corporation (Fdic)

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Yellen Says Treasury Is Ready To Take 'Additional Actions If Warranted' To Stabilize Banks, Christina Wilkie

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Concerning United States Constitutional War Powers, Marcus Armstrong

St. Mary's Law Journal

The United States faces a future in which the possibility of a conventional, great-power conflict is elevated. This is because of a constitutional interpretation that has altered United States constitutional war powers significantly. Specifically, the interpretation gives the president the authority to initiate and escalate war or hostilities unilaterally. In this Article, I reexamine that specific historical interpretation and find it wanting. I then offer a different historical interpretation, drawing upon other contemporary writers as well as upon historical events in order to give a more complete and nuanced understanding of the context in which the early American leaders developed …

Testimony Of Secretary Of The Treasury Janet L. Yellen Before The Financial Services And General Government Appropriations, U.S. House, Janet Yellen

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Federal Open Market Committee, Federal Reserve System: Board Of Governors

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First Republic Shares Fall As Yellen Says Not Considering 'Blanket Insurance' On Bank Deposits, Tatiana Bautzer, Chris Prentice

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Signature Event: Jane Fraser With David M. Rubenstein, Economic Club Of Washington D.C., Jane Fraser, David M. Rubenstein

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Testimony Of Secretary Of The Treasury Janet L. Yellen Before The Financial Services And General Government Appropriations Subcommittee, U.S. Senate, Janet Yellen

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Pacific Western Bank Provides Further Update And Details On Financial Strength, Pacwest Bancorp

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How The Last-Ditch Effort To Save Silicon Valley Bank Failed, Hannah Miao, Gregory Zuckerman, Ben Eisen

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No abstract provided.