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The Characteristics Of Borrelia Hermsii Infection In Human Hematopoeitic Stem Cell-Engrafted Mice Mirror Those Of Human Relapsing Fever, Raja Vuyyuru, Hongqi Liu, Tim Manser, Kishore Alugupalli

Department of Microbiology and Immunology Faculty Papers

Rodents are natural reservoirs for a variety of species of Borrelia that cause relapsing fevers in humans. The murine model of this disease recapitulates many of the clinical manifestations of the human disease and has revealed that T cell-independent antibody responses are required to resolve the bacteremic episodes. However, it is not clear whether such protective humoral responses are mounted in humans.

The Role Of Mer In Apoptotic Cell Clearance In The Germinal Center, Tahsin N. Khan, Eric B. Wong, Ziaur S.M. Rahman, Phd

Department of Microbiology and Immunology Faculty Papers

Germinal centers (GCs) are specialized micro-environments that generate high affinity Ab-forming cells (AFCs) and memory B cells. Many B cells undergo apoptosis during clonal selection in GCs. The TAM (Tyro-3, Axl, and Mer) family receptor tyrosine kinases, including Mer, facilitate macrophage clearance of apoptotic cells. We previously showed that tingible body macrophages (TBMφs) in GCs express Mer. We observed that apoptotic cells (ACs) accumulated in GCs of mice deficient in Mer (Mer-/-), after immunization with T-dependent Ag. Accumulation of ACs in GCs of Mer-/- mice resulted in significantly increased AFCs, GCs, and Th1-skewed IgG2c Ab responses. We report here that …

Predictors Of Appropriate Defibrillator Therapies- A Single Center Analysis, Rina R. Shah, Ratika Gupta, Carrie Stackhouse, Robin Ward, Behzad B. Pavri

Division of Cardiology Faculty Papers

Discussion:

• Although differences in HR and the JT interval were statistically significant in patients who received appropriate shock vs. those who did not, these differences are not clinically meaningful
• We did not identify any clinical predictors of early vs. late ICD shocks
• These data suggest that we may not be able to improve on current guidelines for patient selection for ICD implantation.

Participatory Research At Pathways To Housing-Pa: A Consumer Perspective, Patways To Housing Consumer Health Research Team And Department Of Family And Community Medicine

Department of Family & Community Medicine Presentations and Grand Rounds

Research Question: How does housing affect healthcare decision making?

Methods: 11 Clients took part in a 9-week project focused on health. Using qualitative methodology, weekly meetings were recorded, transcribed, then analyzed resulting in the development of thematic findings.

Characterization Of The Drosophila Slowpoke Binding Protein (Slob) Promoter, Amanda L. Sheldon, Lauren Manderfield, Irwin B. Levitan

Farber Institute for Neuroscience Faculty Papers

Drosophila SLOWPOKE (SLO) is a voltage and calcium dependent, large conductance potassium channel important for action potential repolarization, neuronal excitability, neurotransmitter release, and hormone secretion. SLO binding protein (SLOB) binds to and modulates SLO activity. We have shown previously that modulation of SLO by SLOB has profound effects on SLO channel currents, synaptic transmisison, and metabolism. Multiple isoforms of SLOB exist and are encoded by multiple transcripts; the isoforms are named based on their predicted protein molecular weights, in kilodaltons. In the Drosophila brain, SLOB57/51 proteins are expressed especially prominently in insulin producing neurons of the pars intercerebralis, while SLOB71/65 …

The Prevalence Of Cervico-Arterial Dissection In Sub-Arachnoid Hemorrhage In The United States, Ali Seifi, Md, Fred Rincon, Md, Msc, Mitchell Maltenfort, Phd, Pascal Jabbour, Md, Rodney Bell, Md, Michael Moussouttas, Md

Department of Neurology Faculty Papers

Objectives: In this study, we sought to determine the prevalence of cervico-arterial dissection in aubarachnoid hemorrhage (SAH) using a large administrative database.

Surgical Management Of Fungal Vertebral Osteomyelitis, Benjamin M. Zussman, Bs, David L. Penn, Ms, James S. Harrop, Md

JHN Journal

Fungal vertebral osteomyelitis (FVO) is an uncommon but aggressive disease that may cause spinal instability, neurological insult, and possible death. Little data about treatment strategies and patient outcomes exist. A retrospective review of medical and surgical management with follow-up of this disease was performed.

Bevacizumab: A Controversial Agent Against High-Grade Gliomas, Sussan Salas, Md, Miguel Guzman, Md, Kevin Judy, Md

JHN Journal

Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor in adults. Despite the current regimen of surgical resection with subsequent external beam radiotherapy and temozolomide, mean survival is 14.6 months and 2-year survival is 26%. GBM is a highly vascular tumor, a result of its increased expression of vascular endothelial growth factor (VEGF) compared to other brain tumors. VEGF promotes endothelial cell proliferation, and is thought to have a pivotal role during tumor progression. Multiple treatment modalities have targeted VEGF and VEGF receptors (VEGFTs) due to their essential roles in the regulation of angiogenic processes. Bevacizumab is a …

Macrophages And Neutrophils From Humans And Mice Kill Larval Strongyloides Stercoralis During Innate Immunity, Sandra Bonne-Annee, Laura A. Kerepesi, Jessica A. Hess Ligas, David Abraham, Phd

Department of Microbiology and Immunology Faculty Papers

The parasitic nematode Strongyloides stercoralis (Ss) infects 30-100 million people worldwide, yet little is known about the immune response in humans. Previous studies on innate immunity to Ss in mice have demonstrated a role for eosinophils, neutrophils (PMN) and complement activation in the protective immune response.

Baseline Monitoring Of Standard Health Indicators In A Formerly Homeless Population, Lara Carson Weinstein, Md, Mph, Marianna Lanoue, Phd, Elizabeth Collins, Bs

Department of Family & Community Medicine Presentations and Grand Rounds

Research Question: What are the rates of baseline health status indicators recording at Pathways to Housing (PTH) using select recommended measures from the National Association of State Mental Health Program Directors (NASMHPD) and the Healthcare Effectiveness Data Information Set (HEDIS)?

How do health indicators compare between clients receiving direct clinical care in the integrated care program vs non-integrated care clients?

Individual Agency, Community Capacity Building, And Chronic Illness Care: Using Participatory Methods To Implement The Stanford Chronic Disease Self Management Program In A Housing First Program, Lara Carson Weinstein, Md, Mph, Abbie Santana, Msph, Carolyn Armour, Cornelius Crossan, James Lawson, Karen Webb

Department of Family & Community Medicine Presentations and Grand Rounds

Research questions:

Is a standardized chronic disease self management program (CDSMP) experienced as a valuable intervention by Pathways' consumers?

What is the impact of collaborative inquiry into health program development on participant's critical agency?

Expression Of Cancer Stem Cell Biomarkers In Male Breast Cancer, Ping Gong, Md, Juan P. Palazzo, Md

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Male breast cancer is an uncommon disease, representing <1% of all breast cancer diagnoses. The prognostic factors and expression of molecular markers in male breast carcinomas are similar to female cancer. Cancer stem cell (CSC)s have been associated with tumor aggressiveness and drug resistance. CSCs are characterized by CD44 and/or ALDH1 expression. We investigated their expression in male breast cancer.

The Grizzly, October 27, 2011, Liz Kilmer, Nick Pane, Robert Kelley, Dave Muoio, Lisa Jobe, Sabrina Mcgettigan, Sarah Bollert, Rosie Clark, Stacy Shapiro, Emily Fogel, James Noebels, Marina Mccann, Victoria Cameron, Shane Eachus, Satchel Summers

Ursinus College Grizzly Newspaper, 1978 to Present

New U Fair Welcomes 40+ Vendors • String Ensemble to Make Debut Tomorrow • IT Department Hosts Tech Expo • Internship Profile: Rebecca Kamm • UCARE Community Week • Saturday Night Fun with the Nerf Club • PostSecret Comes to Ursinus College • Opinions: Graduation Change Irritates Students; Campus Safety is a Necessity, Not a Luxury • Roller Hockey Team Resurrected at Ursinus • Stortz and Narang Lead Bears into Cross Country Championships • Senior Spotlight: Jess Porcelan, Women's Soccer

The Grizzly, October 13, 2011, Liz Kilmer, Nick Pane, Hilary Gibbs, Satchel Summers, Lisa Jobe, James Noebels, Connor Gregory, Ron Stranix, Jordan Demcher, Sabrina Mcgettigan, Kyu Chul Shin, Sophie Zander, Dave Muoio, Victoria Cameron

Ursinus College Grizzly Newspaper, 1978 to Present

UCARE Draws More Blood, Donors • "Ursinus is Talking About" Author Speaks on Novel • Annual Security and Fire Safety Report Released • Alcohol-Related Hospitalizations Rise, Confuse Administration • Berman Exhibit Honors Muhlenberg Family • Ursinus GSA Provides "Genuine Acceptance" for All • UC's Dr. Clouser Lectures on Birds' Habitats • Renaissance Band Takes Students Back in Time • Opinion: New Law in Alabama Intrudes on Citizens; Tips to Avoiding the Feared "Freshman 15" • UC Water Polo Stresses Fun Over Seriousness • Men's Soccer Gears Up for the Stretch Run • UC Rugby Making Bigger Commitment

International Evidence On Medical Spending., Robert D. Lieberthal, Phd

College of Population Health Lectures, Presentations, Workshops

The 46th Actuarial Research Conference, Poster session I, University of Connecticut, Storrs, CT. August 11, 2011.

Poster conclusions:

• U.S. spending is high.
• Long tailed medical linked insurance may be easier to write in the U.S.
• U.S. healthcare cost curve is not outrageous.
• Average spending
• Low volatility

Poster is associated with this paper: http://jdc.jefferson.edu/healthpolicyfaculty/45/

International Evidence On Medical Spending., Robert D. Lieberthal, Phd

College of Population Health Lectures, Presentations, Workshops

Presented for the American Statistical Association Health Policy Statistics Section.9th International Conference on Health Policy Statistics, Cleveland, OH.

14 PowerPoint slides

Presentation associated with this paper: http://jdc.jefferson.edu/healthpolicyfaculty/45/.

The Grizzly, October 6, 2011, Liz Kilmer, Nick Pane, Hilary Gibbs, Lisa Jobe, Marina Mccann, Connor Gregory, Sarah Bollert, Lauren Goldstein, Lauren Tedesco, Jordan Demcher, Robert Kelley, Jacquelyn Heikel, Victoria Cameron, Jenna Yaich, Rosie Clark

Ursinus College Grizzly Newspaper, 1978 to Present

Fong, CPPC Developing Strategic Plan • Study Abroad Undergoes Major Changes, Relocation • Art Department Sponsors Trip to New York City • Residence Life Sponsors First-Ever "Sexual Olympics" • Senior Spends Summer Researching Parkinson's • International Film Festival: A Glimpse Into Other Cultures • Wismer on Wheels Offers Helping Hand • Club Promotes Suicide Awareness • Anti-anxiety Group Aims to Relieve Stress • UC Club Soccer Kicks Off First Full Season • UC Fencing Club Looking to Increase its Numbers • Coach Profile: Mark Feinberg, Swimming

Strategies For Financing Healthcare Costs Over The Long Term., Robert D. Lieberthal, Phd

College of Population Health Lectures, Presentations, Workshops

Presented for the American Statistical Association Health Policy Statistics Section. 9th International Conference on Health Policy Statistics, Poster session I, Cleveland, OH.

Funding to support this work came from AHRQ grant R36 HS018835-01.

Policy Implications:

-Health insurance companies should use a broad, diversified investment portfolio as their optimal investment strategy -Insurance regulators should be focused on longer term lines of health insurance

High Frequency Evidence On Variation In Spending Growth., Robert D. Lieberthal, Phd

College of Population Health Lectures, Presentations, Workshops

Presented for the American Statistical Association Health Policy Statistics Section. 9th International Conference on Health Policy Statistics, Poster session I, Cleveland, OH.

Policy Implications:

• Health insurance regulation should include compensation for taking on riskier groups.
• Health programs should focus on changing needs for risk management versus health management throughout the life cycle.

Funding to support this work came from AHRQ grant R36 HS018835-01.

Elizabeth Blackwell, Md Nation's First Female Physician, Michael Angelo, Matt Varrato

50 and Forward: Posters

Poster highlights British-born Elizabeth Blackwell (1821-1910) and important years for Jefferson Medical College and women (1849, 1850, 1869, 1891 and 1894.

United States Medicine, Women And Jefferson Medical College, Michael Angelo, Matt Varrato

50 and Forward: Posters

Poster with timeline from 1824 to 2008 highlighting contributions to Medicine by women in the United States and Jefferson Medical College.

Flexner Report: Medical Schools Are Evaluated, Michael Angelo, Matt Varrato

50 and Forward: Posters

Poster highlighting the Flexner Report, Jefferson Medical College and contributions of women including Lolita Pannell, PhD, Sonia Schorr, Elizabeth M. Bogardus, MD, Vera (Easling) Dettweiler, MD and Evelyn D. Schmidt, MD.

Leah Lowenstein, Md Nation's First Female Dean Of A Co-Ed Medical School (1981), Michael Angelo, Matt Varrato

50 and Forward: Posters

Poster highlighting Leah Lowenstein, MD the nation's first female Dean of a co-ed medical school. Though last to admit female students, Jefferson Medical College was the first co-educational medical school to appoint a woman as dean.

Ursinus Magazine, Fall 2011, Wendy Greenberg, Kathryn Campbell, Ellen Labrecque, Bobby Fong, Gerald Edelman, Erika Compton, Joseph H. Melrose, Joseph F. Pirro

Ursinus Magazine, 1995–Present

Dr. Fong speaks on the future of Ursinus • Pre-Law Center begins at Ursinus • New faces on court and field • Good night Irene: A rainy move-in • Let's dance: Visiting artists will teach • Math and Computer Science Department professor awarded grant • Do you blog? • Dr. Fong receives 2011 Pioneer Award • Fond farewells • Focus of international math conference is disease control • Noise of change on campus • The Philip and Muriel Berman Museum of Art exhibitions on view • Friends old and new celebrated Alumni & Reunions Weekend • Mapping the mind • …

Validating The Pridit Method For Determining Hospital Quality With Outcomes Data., Robert D. Lieberthal, Phd, Dominique Comer, Pharmd, Katherine O’Connell, Bs

College of Population Health Lectures, Presentations, Workshops

Presented for The 46th Actuarial Research Conference, University of Connecticut, Storrs, CT.

15 PowerPoint slides

International Evidence On Medical Spending Risk., Robert D. Lieberthal, Phd

College of Population Health Lectures, Presentations, Workshops

Presented for the American Risk and Insurance Association. 2011 ARIA Annual Meeting, San Diego, CA.

20 PowerPoint slides.

Presentation is associated with the paper: http://jdc.jefferson.edu/healthpolicyfaculty/45/

Department Of Radiology-Annual Executive Summary Report-July 1, 2010 To June 30, 2011, Vijay M. Rao, Md

Department of Radiology Administrative Documents and Reports

90 page Department of Radiology Annual Executive Summary Report, July 1, 2010 to June 30, 2011, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States.

Tables of Contents:

Department of Radiology

Chairman, Vice Chairmen 1

Divisions and Directors 1

Committees and Chairmen 1

Radiology Department Faculty Rank 2

Faculty with Secondary Appointments 3

Clinical Divisions 4

Radiology Residents and Fellows 5

Department Organizational Chart 6

Department Administration Chart 7

State of the Department 8

Appendix I: Publications Journal Articles 22

Books and Book Chapters 30

Abstracts 33

Appendix II: Formal Scientific Presentations 44

Appendix III: Honors, Editorial Activities, Service to Regional …

Slides: The Costs And Benefits Of Best Management Practices: Insights From The Marcellus Shale, Timothy J. Considine

Best Management Practices (BMPs): What? How? And Why? (May 26)

Presenter: Timothy J. Considine, School of Energy Resources, Department of Economics and Finance, University of Wyoming

15 slides

Academic Detailing To Increase Colorectal Cancer Screening By Primary Care Practices In Appalachian Pennsylvania, William J. Curry, Eugene J. Lengerich, Brenda C. Kluhsman, Marie A. Graybill, Jason Z. Liao, Eric W. Schaefer, Angela M. Spleen, Mark B. Dignan

Internal Medicine Faculty Publications

BACKGROUND: In the United States, colorectal cancer (CRC) is the third most frequently diagnosed cancer and second leading cause of cancer death. Screening is a primary method to prevent CRC, yet screening remains low in the U.S. and particularly in Appalachian Pennsylvania, a largely rural area with high rates of poverty, limited health care access, and increased CRC incidence and mortality rates. Receiving a physician recommendation for CRC screening is a primary predictor for patient adherence with screening guidelines. One strategy to disseminate practice-oriented interventions is academic detailing (AD), a method that transfers knowledge or methods to physicians, nurses or …

Compromise And Release Settlements In Workers' Compensation: Final Report, H. Allan Hunt, Peter S. Barth

Reports

No abstract provided.