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Differential Methylation Patterns In Lean And Obese Non-Alcoholic Steatohepatitis-Associated Hepatocellular Carcinoma, Emma Hymel, Kurt W. Fisher, Evi A. Farazi

Journal Articles: Epidemiology

BACKGROUND: Nonalcoholic fatty liver disease affects about 24% of the world's population and may progress to nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma (HCC). While more common in those that are obese, NASH-HCC can develop in lean individuals. The mechanisms by which HCC develops and the role of epigenetic changes in the context of obesity and normal weight are not well understood.

METHODS: In this study, we used previously generated mouse models of lean and obese HCC using a choline deficient/high trans-fat/fructose/cholesterol diet and a choline supplemented/high trans-fat/fructose/cholesterol diet, respectively, to evaluate methylation differences in HCC progression in lean versus …

Primary Care Provider Education On Behavioral Interventions For Management Of Adult, Rose Chinasa Kajuru

Walden Dissertations and Doctoral Studies

The high prevalence of obesity continues to pose significant health challenges globally. According to the U.S. Preventive Service Task Force, obesity affects more than 35% of men and 40% of women in the United States. The national annual cost of medical care related to obesity is estimated at $147 to $210 billion. Intensive behavioral interventions in adults with obesity can lead to clinically sufficient improvements. The project aimed to determine if the current evidence-based clinical guideline of behavioral weight loss interventions to prevent obesity-related morbidity and mortality in adults would improve primary care providers’ knowledge of adult obesity management. The …

The Role Of Health And Diet In The Development Of Metabolic Syndrome Stratified By Race, Sex, And Age, Michael D. Harada

Walden Dissertations and Doctoral Studies

Obesity is now recognized as a disease in need of treatment by the medical profession and is associated with other chronic diseases including hypertension, hyperglycemia, hypertriglyceridemia, insulin-resistance, and reduced levels of high density lipoproteins. Metabolic syndrome (MetS) occurs when a combination of at least three of these chronic conditions are comorbid with each other. The purpose of this quantitative cross-sectional study was to find significant health and nutritional predictors of MetS status across race, sex, and age. The evolutionary mismatch hypothesis and health belief model provided the framework for this study. Data were collected from 2,303 participants from the 2015-2016 …

Body Satisfaction And Self-Efficacy As A Predictor For Obesity Among African American College Women, Sacha Nicole Morris-Dorsey

Walden Dissertations and Doctoral Studies

African American women have the highest rates of obesity when compared to any ethnic group in the United States, and the rates of obesity among this population are expected to continue to increase. In this study, social cognitive theory was used to predict the connection between body satisfaction, self-efficacy, and obesity in 18–24-year-old African American women attending college. The data were analyzed using multiple regression, while controlling for demographic variables, to determine if body satisfaction (Body-Esteem Scale for Adolescents and Adults) and self-efficacy (The Eating Self-Efficacy Scale) predicted obesity among African American women in college. Thirty-three participants completed the survey. …

Obesity's Impact Among Asian Americans In Southern California, Alyssa Mae Sunga Carlos

Walden Dissertations and Doctoral Studies

Obesity continues to be an important public health issue in the United States, especially among minority populations. However, one minority group experiences the lowest obesity rate: Asian Americans. As a result, there is not much research available involving the impact of obesity and weight gain among this population. The purpose of this basic qualitative exploratory study was to improve the understanding of obesity’s impact on the Asian American population, specifically in Southern California, whose goals were to lose weight and become more informed about obesity’s impact on health. The study consisted of three main research questions. Twenty-five participants were interviewed …

Nutrition And Physical Exercise Prevention Strategies To Reduce Obesity During The Covid-19 Pandemic, Carmesha Vajill Carter

Walden Dissertations and Doctoral Studies

Obesity has reached an epidemic level of 75 million obese adults and 15 million obese children in the United States. The research problem addressed in this study is the lack of information on how obese people manage their weight-loss strategies to prevent or reduce obesity during shut-in place restrictions for the COVID-19 Pandemic. This study included the Prochaska and DiClemente Trans-Theoretical Model of Behavioral Change and the Stage of Change Theory. The phenomenon approach using phenomenology described participants' lived experiences of being obese. The researcher completed data collection and evaluation among sixteen participants using email questionnaires to analyze participant's responses …

Mothers' Perceptions Of Their Children's Weight: Opportunity For Health Promotion In Kuwait, Abdullah Al-Taiar, Nawal Alqaoud, Reem Sharaf-Alddin, Muge Akpinar-Elci

Community & Environmental Health Faculty Publications

Background: Mothers’ perceptions of their children’s weight remain mostly unknown in oil-rich countries of the Middle East.

Aims: To compare maternal perceptions of their children’s weight with actual body weight.

Methods: We used the Kuwait nutritional surveillance data for 5 consecutive years (2015-2019) (N = 5119), which were collected through face-to-face interviews with mothers of children aged 2-5 years attending vaccination centres.

Results: Of the 5119 mothers in the study, 163 (3.18%) and 332 (6.48%) had obese or overweight children, respectively. Among 4624 mothers who had normal weight children, 1350 (29.20%) perceived their children’s weight as …

Obesity: Understanding And Achieving A Healthy Weight, George A. Bray, Catherine M. Champagne

Population and Public Health Science Faculty Publications

Obesity is a chronic, relapsing, stigmatized disease process that is increasing in prevalence, affecting both adults and children. It is the result of a small positive energy imbalance from too much food or too little activity. These underlying causes are influenced by many environmental factors. The food we eat is more than “calories,” and focusing on calories alone may not be as productive as focusing on patterns of eating and the role of sugar and fat in the diet. Obesity increases the risk of many diseases and shortens life span, and weight loss provides benefits in reducing health risks and …

The Complicated Relationship Between Dieting, Dietary Restraint, Caloric Restriction, And Eating Disorders: Is A Shift In Public Health Messaging Warranted?, Tiffany M. Stewart, Corby K. Martin, Donald A. Williamson

Clinical Research Faculty Publications

The origins of theories specifying dietary restraint as a cause of eating disorders can be traced to the 1970s. This paper will present an overview of the origins of dietary restraint theories and a brief historical review of evidence will be summarized. Recent research will be presented, including the results from the CALERIE Phase 1 study, as well as CALERIE Phase 2, which were NIH-sponsored randomized controlled trials. CALERIE 2 provided a test of the effect of two years of caloric restriction (CR) on the development of eating disorder syndromes and symptoms in comparison to a control group that did …

Association Of Night-Time Screen-Viewing With Adolescents’ Diet, Sleep, Weight Status, And Adiposity, Chelsea L. Kracht, Jordan Gracie Wilburn, Stephanie T. Broyles, Peter T. Katzmarzyk, Amanda E. Staiano

Population and Public Health Science Faculty Publications

Night-time screen-viewing (SV) contributes to inadequate sleep and poor diet, and subse-quently excess weight. Adolescents may use many devices at night, which can provide additional night-time SV. Purpose: To identify night-time SV patterns, and describe differences in diet, sleep, weight status, and adiposity between patterns in a cross-sectional and longitudinal manner. Methods: Adolescents (10–16 y) reported devices they viewed at night and completed food recalls. Accelerome-try, anthropometrics, and imaging were conducted to measure sleep, weight status, and adiposity, respectively. Latent class analysis was performed to identify night-time SV clusters. Linear regression analysis was used to examine associations between clusters with …

Lived Experience Of Albanian Migrants Who Became Obese After Moving To The United States, Briseida Xhelaj

Walden Dissertations and Doctoral Studies

The problem of obesity is significant in the United States, and more information is needed about the factors that increase the risk for obesity among migrant populations like Albanian Americans. The purpose of this study was to discover the lived experience of Albanian migrants who became obese after moving to the United States. This study was guided by the social ecological model. The research questions were used to examine how individual, relationship, community, and societal level factors impacted lifestyle changes and obesity for Albanian American migrants after moving to the United States. This qualitative study involved the use of a …

Potential Impact Of Socioeconomic Status On Complications Associated With Obesity In Adult Women In The United States., Cassidy Taylor

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Abstract

The purpose of this project is to determine whether there is an association between socioeconomic factors and complications of obesity in adult women in the United States based on the national 2020 Behavioral Risk Factor Surveillance System (BRFSS) data.

Dependent variables were categorized as complications associated with obesity in adult, obese women. BRFSS items that referenced objective measures regarding chronic obesity-related complications included items such as diabetes, heart disease, arthritis, and breast cancer diagnosis. Two measures relating to participants’ socioeconomic status were also used as independent variables. BRFSS items that referenced objective measures regarding socioeconomic status are educational attainment, …

Childhood Obesity Interventions In The Republic Of Trinidad And Tobago: A Qualitative Study Exploring Government Policies And Their Implementation By Health Practitioners, Phyllis Woolford

Dissertations

Because of the rising prevalence of childhood obesity and overweight in the Republic of Trinidad and Tobago, and the observation that efforts to address the problem were showing disappointing results, this study seeks to explore the experiences and views of policymakers, health practitioners, and parents of overweight and obese children, in order to inform leaders and policy makers regarding the current interventions.

Method

A qualitative research case study methodology is the research design used, which, with my research questions, I considered would best uncover knowledge and provide perspectives that would provide an increased understanding of the issues arising from the …

Project Spraoi: The Implementation And Outcomes Of A Process Evaluation Of A School-Based Health Promotion Intervention, Yvonne Larrissa O’Byrne

Theses

Large multi-site school-based interventions are challenging to implement and difficult to evaluate due to the complex adaptive nature of schools as a research setting. This study focused on implementing a comprehensive process evaluation of a multicomponent primary school-based health promotion called Project Spraoi (PS), alongside intervention delivery, to aid the translation of outcomes and understand the moderating role of contextual factors on intervention delivery. PS is led by a physical activity (PA) specialist known as an Energizer and aims to improve children’s PA levels and reduce sedentary time by delivering 20 minutes extra daily moderate to vigorous PA (MVPA) during …

Implementation Of Farmers Markets In Bell County, Kentucky, Rachael Schmetzer

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

This proposal addresses the link between food insecurity and obesity through the implementation of farmers markets in Bell County, Kentucky as a way to increase access and consumption of fruits and vegetables in this rural, low-income community.

Evaluation Of Cardiovascular Changes In Patients With Gastric Wall Fat Halo Sign, Ali̇ Küpeli̇, Eser Bulut, Edhem Ünver, Gürkan Danişan

Turkish Journal of Medical Sciences

Background/aim: This study aims to investigate the relationship between gastric wall fat halo sign and potentially associated cardiovascular disease (CVD) in thoracic computed tomography (CT). Materials and methods: Between October 2020 and January 2021, 62 patients with gastric wall fat halo sign and 62 controls were evaluated with thorax CT. Patient's height, weight, body mass index (BMI), sex, age, comorbidities, laboratory parameters, diameters of cardiac axes, aorta and pulmonary artery; aorta and coronary artery calcium scores were recorded for the two groups. Results: No significant differences were found in sex, age, height, body weight or BMI between the two groups …

Decreasing Physical Inactivity Among Adolescents, Anthony W. Ware

Walden Dissertations and Doctoral Studies

AbstractAdolescents in the United States have become complacent about being involved in an adequate amount of physical activity and consuming a healthy diet. This has led to adolescents having health issues such as overweight status and obesity. The U.S. Department of Health and Human Services Centers for Disease Control and Prevention made recommendations for adolescents to maintain an adequate level of physical activity and to consume a healthy diet. In this study I hypothesized that students who were surveyed in the 2017 Youth Risk Behavior Survey who practiced both physical activity and healthy diet recommendations together would have a lower …

Stories Of Adults Experiencing Overweight Or Obesity With Histories Of Childhood Adversities, Megan Propps

Walden Dissertations and Doctoral Studies

More than half the population in and outside of the United States experience childhood adversity, which is associated with the risk of developing obesity and overweight problems across the life span. In the United States, overweight affects 73.6% of adults, obesity affects 42.5% of adults, and both are considered a major public health concern. With this qualitative study, 18 adults with early life adversities were explored as to how experience weight loss treatment within their primary care. This narrative inquiry was designed to answer the research questions intended to explore physical health, mental health, and socio-environmental aspects of their stories, …

Nursing Staff Education Project To Improve Diabetic Patients' Glycemic Control, Valerie R. Gaston

Walden Dissertations and Doctoral Studies

Diabetes is a chronic disease affecting more than 34.2 million people in the United States. The International Diabetes Federation predicted by the year 2045 an estimated 700 million people will have diabetes. In the clinic project site, the practice problem involved the increasing clinician’s knowledge about Type 2 diabetes mellitus (T2DM) with improved glycemic control through self-care management. The purpose of this project was to develop an educational training and intervention for staff to increase their knowledge of self-care management to improve glycemic control and have it validated by a panel of experts before dispersing it to the intended audience. …

Modeling The Effects Of Adverse Childhood Experiences Using A Mouse Model Of Neglect: Mechanisms Of Adiposity Expansion In Females, Jacqueline Leachman

Theses and Dissertations--Pharmacology and Nutritional Sciences

Adverse childhood experiences (ACEs) are an independent risk factor for chronic disease, including obesity and metabolic syndrome. We have previously shown that a mouse model of early life stress, maternal separation and early weaning (MSEW), exacerbates high-fat diet (HF)-induced obesity only in adult female mice. In agreement, the analysis of several cohorts of participants exposed to ACEs have shown that women are more susceptible to develop obesity than men. Therefore, the aim of this study was to investigate the link between early life stress and obesity in pre-clinical and clinical settings. Male and female MSEW mice fed 1 week a …

A Pilot Randomized Trial To Assess Motivating Operations In Delay Discounting Of Food, Breeanna Michelle Slusher

Graduate Theses/Dissertations

This pilot study addresses the impact motivating operations have on delay discounting of food in the presence of real food. Six participants were recruited and randomly assigned to three food stimuli groups (donut, vegetable, and control) and assigned to either a deprivation or non-deprivation condition within the group. Participants were asked to complete a set of questionnaires and a delay discounting task. Demographics and anthropometric measurements were obtained from each participant. The pilot study showed support for previous delay discounting research that as the delay to more nutrient dense meals increases the subjective value of the delayed reward decreases. Thus, …

Examining Sex And Race Difference In Obesity Risk Factors In Older Americans Using Genetic And Lifestyle Data In Regards, Hairui Yu

All ETDs from UAB

Obesity is a prevalent chronic condition determined by social, psychological, behavioral, and biological factors. The prevalence of obesity remains a major public health issue and has continued to rise in the United States and around the world. People who are obese face a higher risk of cardiovascular and metabolic diseases. The fat mass and obesityassociated gene (FTO) is one of the most commonly identified genes in obesity-related research. This three-paper dissertation is aimed at improving understanding of sex and race differences in obesity risk factors in older Americans from genetic (FTO SNPs) and lifestyle (diet and physical activity) perspectives, using …

Investigating The Effects Of Body Weight Fluctuations On Insulin Resistance In Adults: A Nhanes Study, Jessica Claire Burke

All Master's Theses

The aim of this study was to investigate the effects of a history of weight cycling on insulin resistance (IR) utilizing the 2015-2020 NHANES database. A value greater than 3.2 for homeostatic model assessment of insulin resistance (HOMA-IR) was used to define IR. No study to date has examined the weight cycling question since its application in the NHANES 2015-2016 cycle year. RESULTS 53% of the total 4100 participants reported weight cycling at least once and 33% of the total were classified as having IR. Prevalence of IR and obesity were highest amongst those who weight cycled 3 times or …

Implementing A Faith-Based Weight Loss Outreach Program For The Westside Community Of Jacksonville, Florida, Jonathan Peinado

Doctor of Ministry Projects

Problem

Jacksonville, Florida’s adult population has an obesity rate of 65.4% which is slightly lower than both regional and national averages (66.1%) but higher than the state average (63.2%).

Method

A faith-based weight loss program was developed for the residents of the west side of Jacksonville. The intervention incorporated behavioral, spiritual, and psychological modules. The program lasted a total of 10 weeks from beginning to end, with the main segment taking place over a 40-day (6-week) period. Participants underwent two biometric screenings, one at the beginning of the program and one at the end. They had daily health challenges such …

African American Women’S Body Image Perceptions And The Built Environment, Andrea Denise Smith

Walden Dissertations and Doctoral Studies

African American (AA) women have a 54.8% overall obesity rate in the United States. This quantitative cross-sectional study’s aim was to determine what factors may have an impact on body image perceptions of AA women in Alabama and New Jersey. A gap in research this study addressed is sociodemographic and geographic differences that may impact obesity rates among AA women. The theoretical framework used for this study was the social cognitive theory. Secondary data were obtained from the 2018 Behavioral Risk Factor Surveillance System. Linear regression (LR) analyses results showed that none of the sociodemographic variables (education level, employment status, …

Complexities And Complications Of Extreme Obesity, Haval Ali, Udit Naik, Michelle Mcdonald, Mohammad Almosa, Karen Horn, Alexis Staines, Louis Maximilian Buja

Faculty, Staff and Student Publications

Obesity is a common chronic disorder and has detrimental long-term consequences if left untreated. Herein, we report a case of a young lady who suffered from morbid obesity and many of its consequences, and we present a literature review of these complications. While the cause of obesity is multifactorial, the genetic component is particularly important in the pathophysiology of marked obesity. Resistance to Leptin is considered one of the main causes of obesity. There is a unique relationship between polycystic ovary syndrome and obesity, as observed in our case. Obesity is associated with cardiovascular and lung diseases such as heart …

Is Phentermine/Topiramate Er With Lifestyle Modifications Effective In Achieving Weight Loss In Obese Patients With Comorbidities?, Elizabeth A. Stubbs

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not “Is phentermine/topiramate ER with lifestyle modifications effective in achieving weight loss in obese patients with comorbidities?”

Study Design: A systematic review of three placebo-controlled randomized controlled trials (RCTs) published in English in 2012 or after.

Data Sources: All three studies were found by searching PubMed and were published in peer-reviewed journals. The articles were selected based on ability to answer the proposed question.

Outcome Measured: Percent weight loss was the outcome measured in all three studies. This was measured based on mean percent weight loss from …

Deletion Of Period Genes Exacerbates Diet-Induced Obesity In Female, But Not Male, Mice, Elizabeth Kantra

Theses and Dissertations--Biology

Sex differences in obesity in mice are mediated by differential responses of circadian rhythms to high-fat feeding in males and females. Other studies also showed circadian Period genes regulate diet-induced obesity in mice. In this study, we investigated the role of the Period genes in regulating sex differences in obesity. Male and female C57BL/6J wild type, Per1/2 KO, and Per1/2/3 KO mice were housed in 12L:12D and fed high-fat diet for 12 weeks. We found a striking sex difference in obesity such that disabling the Period genes exacerbated adiposity in female, but not male, mice. Increased adiposity in female Period …

Improving Nutrition Literacy In Primary Care, Kami D. Dykes

DNP Research Projects

Abstract

By the year 2030, nearly one in every two adults will have obesity (Body Mass Index [BMI] ≥30 kg/m².), and one in four adults will have severe obesity (BMI ≥35 kg/m²) (Ward et al., 2019). Equally troubling is that obesity poses a threat to the health of individuals, decreases the quality of life, shortens life expectancy, causes and worsens comorbidities, and increases all- cause mortality (Abdelaal et al., 2017). Studies have shown a link between BMI, nutritional knowledge, and dietary practices. Nutrition literacy is a newer term that refers to the complex relationship between nutrition …

Paraventricular Vitamin D Receptors Are Required For Glucose Tolerance In Males But Not Females, Jessie Beck, Silvania Da Silva Teixeira, Keisha Harrison, Gabrielle Phillips, Yanlin He, Stephanie Sisley

Faculty, Staff and Students Publications

When delivered directly into the brain, vitamin D, can improve glucose levels in male mice. Additionally, the loss of the vitamin D receptor (VDR) in male mice's paraventricular hypothalamus (PVH) results in impaired glucose tolerance. Data in humans shows that low vitamin D levels are detrimental to glucose homeostasis, an effect that may be more prominent in men. However, it is unknown if vitamin D action in the brain is required for normal glucose regulation in female mice. This study shows that in both viral and genetic models, male mice with obesity and PVH VDR loss have impaired glucose tolerance …