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An Investigation Of Perinatal Polychlorinated Biphenyl Exposure On Body Composition And Glucose Homeostasis, Cetewayo S. Rashid

Theses and Dissertations--Nutritional Sciences

Recent advancements have uncovered environmental contributions to obesity and diabetes etiology. In fact, perinatal malnutrition resulting in low birth weight (LBW) has been shown to correlate with later life obesity and impaired glucose tolerance in aged offspring. LBW can result from a myriad of developmental perturbations including macronutrient restriction, hypoxia, maternal stress and toxin exposure.

Polychlorinated biphenyls (PCBs) are ubiquitous environmental pollutants that bioaccumulate in the food chain resulting in dietary exposure in humans. Maternal and cord blood PCB levels are inversely associated with birth weight, and recent studies indicate that perinatal exposures to PCBs contribute to gender-specific obesity development …

Business Plan: Sports Facility In Rochester, Minnesota, Nikki Scherr

Master of Arts in Sport Management

This capstone project involves the construction of a new sports facility, The Sports Hut, located in Rochester, Minnesota. The mission of The Sports Hut organization is to get kids active at a young age, which allows the opportunity for athletes to thrive in their sport and passions, while providing a place to learn and grow in a healthy environment. Although obesity can be a very complex issue, Miller, Rosenbloom and Silverstein (2004) have discovered that obesity affects more than 30% of children and can be found commonly due to the environment and lifestyle in which they group up in. It …

Novel Insights Into The Function And Regulation Of Group X Secretory Phospholipase A2, Joseph D. Layne Jr

Theses and Dissertations--Nutritional Sciences

Group X secretory phospholipase A₂ (GX sPLA₂) hydrolyzes membrane phospholipids producing free fatty acids and lysophospholipids. Previous studies from our lab suggest that mice with targeted deletion of GX sPLA₂ (GX KO) have increased age-related weight gain due to an increase in overall adiposity. Paradoxically, this increased adiposity is associated with improved age-related glucose intolerance. GX KO mice also demonstrate a reduced inflammatory response to lipopolysaccharide injection. In vitro studies indicate this phenotype may be attributable to blunted macrophage mediated inflammatory responses. Given the role of macrophages in promoting adipose tissue (AT) inflammation and metabolic dysfunction …

Impact Of Obesity On Il-12 Family Gene Expression In Insulin Responsive Tissues, Heesun Nam, Bradley S. Ferguson, Jacqueline M. Stephens, Ron F. Morrison

Faculty Publications

Mounting evidence has established a role for chronic inflammation in the development of obesity-induced insulin resistance, as genetic ablation of pro-inflammatory cytokines and chemokines elevated in obesity improves insulin signaling in vitro and in vivo. Recent evidence further highlights interleukin (IL)-12 family cytokines as prospective inflammatory mediators linking obesity to insulin resistance. In this study, we present empirical evidence demonstrating that IL-12 family related genes are expressed and regulated in insulin-responsive tissues under conditions of obesity. First, we report that respective mRNAs for each of the known members of this cytokine family are expressed within detectable ranges in WAT, skeletal …

The Impact Of Nutrition Information Delivery Methods On Restaurant Consumers' Attitudes And Behavior, Jiaqi Zhu

Open Access Theses

Zhu, Jiaqi. M.S., Purdue University, December 2013. The Impact of Nutrition Information Delivery Methods on Restaurant Consumers' Attitudes and Behavior. Major Professors: Barbara A. Almanza, Carl A. Behnke.

Obesity is a major public health threat. It not only creates challenges for those who are obese and overweight, but also brings an economic burden to the whole society. One important contributing factor for obesity is food eaten away from home, which accounts for more than 40% of American's food budget. Although chain quick-service restaurants are required by law to post calorie information on menus and menu boards, the efficacy of menu …

Participation In Immersion Weight Loss Treatment May Benefit, Not Harm, Young Adult Staff Members, Katherine Elizabeth Schaumberg

Legacy Theses & Dissertations (2009 - 2024)

American teens and young adults are at risk for developing pathological eating patterns, which can lead to eating disorders and obesity. Despite the success of weight management programs for obese individuals, some researchers caution that participation in an aggressive approach to weight management could promote the development of eating disorders. The current study evaluated the risks of following a weight management program for healthy young adults who served as staff members in immersion treatment of obesity over the course of a summer. Participants included Wellspring staff members (n = 108) along with a comparison group of young adults with similar …

Exposure To Persistent Organic Pollutants And Metabolic Diseases, Zafar Zayirovich Aminov

Legacy Theses & Dissertations (2009 - 2024)

Background: The metabolic syndrome (MetS) is a group of diseases that tend to occur together, including diabetes, hypertension, central obesity, cardiovascular disease and hyperlipidemia. Exposure to persistent organic pollutants (POPs) such as polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) have been associated with increased risk of development of several of the components of the MetS.

Using Geospatial Technologies To Characterize Relationships Between Travel Behavior, Food Availability, And Health, Warren J. Christian

Theses and Dissertations--Geography

Epidemic obesity in the U.S. has prompted exploration of causal factors related to the built environment. Recent research has noted statistical associations between the spatial accessibility of retail food sources, such as supermarkets, convenience stores, and restaurants, and individual characteristics such as weight, socioeconomic status, and race/ethnicity. These studies typically use residential proximity or neighborhood density to food sources as the measure of accessibility. Assessing food environments in this manner, however, is very limiting. Since most people travel outside of their neighborhood on a daily basis, the retail food sources available to individuals residing in the same area could vary …

The Effects Of A High Fat Diet On Mitochondrial Biogenesis And Inflammation In The Brain., Lauren Suzanne Vervaecke

Theses and Dissertations

INTRO: High fat diets (HFD) ingested over long periods of time have been shown to cause diet induced obesity leading to excessive adiposity and chronic low grade inflammation. Here we have shown how differing levels of saturated fats (SF), which are common storage fats, affect markers of inflammation and mitochondrial biogenesis. IL-1â and TNF-alpha are pro-inflammatory cytokines that have been shown to increase with a HFD, while molecular signalers, PGC-1alpha, cyt c, and SIRT1, related to mitochondrial biogenesis have been shown to decrease. Despite the risks of consuming a diet high in SF's, consumers continue to buy energy dense foods …

Associations Between Resting Metabolic Rate And Energy Storage In Young Adults, Robin Shook

Theses and Dissertations

At the most basic level obesity is the result of a chronic imbalance between energy intake and energy expenditure. However, the exact etiology is considerably more complex and may involve a variety of physiological and behavioral factors. Metabolic disturbances, including reduced fat oxidation as measured by the respiratory quotient (RQ) and reduced resting metabolic rate (RMR), have been identified as possible predictors of changes in body weight and body composition. RMR represents the largest component (60-80%) of caloric expenditure that contributes to total daily energy expenditure in humans and has high inter-person variability (±25%) but not within individuals (<±5%). The cause of this variability between individuals and the exact role of RMR and RQ in determining body weight and body composition are uncertain.

This …

The Effect Of Alpha-Cyclodextrin On Acute Blood Lipid And Glycemic Responses To A Fat Containg Meal, Evan Neil Fletcher

Wayne State University Theses

Obesity and hyperlipidemia have become major concerns in the United States over the past 30 years. Alpha-Cyclodextrin (á-CD), a naturally occurring soluble dietary fiber, has been shown to reduce dietary fat absorption and improve blood lipid levels in an animal model (mouse and rat) and in human studies. In the current double blind study, 34 healthy male and female participants were recruited to test if á-CD had any acute effect on blood lipid and glycemic responses to a fat containing meal. The participants received the á-CD on one occasion and a placebo the other to determine if there was any …

Tackling Overweight And Obesity: Does The Public Health Message Match The Science?, Katherine Hafekost, David Lawrence, Francis Mitrou, Therese O'Sullivan, Stephen R. Zubrick

Research outputs 2013

Background

Despite the increasing understanding of the mechanisms relating to weight loss and maintenance, there are currently no validated public health interventions that are able to achieve sustained long-term weight loss or to stem the increasing prevalence of obesity in the population. We aimed to examine the models of energy balance underpinning current research about weight-loss intervention from the field of public health, and to determine whether they are consistent with the model provided by basic science. EMBASE was searched for papers published in 2011 on weight-loss interventions. We extracted details of the population, nature of the intervention, and key …

Relationship Between Childhood Sexual Abuse, Weight, And Attitudes Toward Obesity In Lesbians, Amy L. Wright

LSU Master's Theses

In many professional practice settings, it is very likely that social workers will work with female clients who identify as lesbian or bisexual. These sexual minority females are more likely to be overweight or obese, have a history of childhood sexual abuse, and have more positive attitudes toward overweight and obesity than heterosexual women. In this study, the author sought to identify the relationship between childhood sexual abuse, obesity, (specifically, body mass index [BMI]), and attitudes toward obesity among lesbian and bisexual women. Eighty-five sexual minority females completed a survey. Childhood sexual abuse was found to be positively correlated with …

Lifestyle Factors, Medication Use And Risk For Ischaemic Heart Disease Hospitalisation: A Longitudinal Population-Based Study, Anthony S. Gunnell, K Einarsdottir, Daniel A. Galvao, S Joyce, S Tomlin, Vicki J. Graham, Caroline Mcintyre, Robert U. Newton, T Briffa

Research outputs 2013

Background:Lifestyle factors have been implicated in ischaemic heart disease (IHD) development however a limited number of longitudinal studies report results stratified by cardio-protective medication use.Purpose:This study investigated the influence of self-reported lifestyle factors on hospitalisation for IHD, stratified by blood pressure and/or lipid-lowering therapy.Methods:A population-based cohort of 14,890 participants aged 45+ years and IHD-free was identified from the Western Australian Health and wellbeing Surveillance System (2004 to 2010 inclusive), and linked with hospital administrative data. Adjusted hazard ratios for future IHD-hospitalisation were estimated using Cox regression.Results:Current smokers remained at higher risk for IHD-hospitalisation (adjusted HR=1.57; 95% CI: 1.22-2.03) after adjustment …

Predictors Of Successful Weight Loss Following Bariatric Surgery, Francine R. Broder

PCOM Psychology Dissertations

Obesity is a major public health problem involving both medical and quality-of-life
issues. During the past 20 years, obesity has dramatically increased and is currently at an all-time high (Centers for Disease Control and Prevention, 2011). More than two thirds of the adult population in the United States is estimated to be overweight, with over one third of the population classified as obese (National Institute of Health, 2009). While attempting to lose weight is common, calorie reduction combined with physical activity typically results in 5 to 10 % reduction of body weight over a 6-month period, yet these moderate losses …

An Ethical Justification Of Weight Loss Surgery, Amy Marie Vandyke

Electronic Theses and Dissertations

This dissertation provides an ethical justification of surgical weight loss interventions for the treatment of obesity. Situating obesity as not merely a public health concern but also fundamentally a problem of clinical medicine confronting individual patients and physicians, the dissertation argues that the time frame of public health interventions is too long for individuals presently facing obesity and its deleterious physical and social co-morbidities. It argues that failure to address weight loss on an individual level, and specifically to consider the clinical appropriateness of weight loss surgery (WLS), raises serious questions about failure to respect autonomy and promote patient welfare. …

Social Cognitive Theory Vs. Social Comparison Theory: Examining The Relationship Between Social Influence And Weight Loss, Emily Grigg

Masters Theses

This qualitative study investigated the impact of social influence on weight loss, more specifically, the internal and external elements that effect response and success of those who are trying to lose weight. The research focused on three questions: (1) How great of an influence does self-efficacy have in weight loss success? (2) How great of an influence does social comparison have in weight loss success? (3) Which factor has the largest impact on weight loss: self-efficacy, peer efficacy, or positive social support, or negative social support? Data was collected by the researcher conducting semi-structured interviews. These interview were conducted with …

The Role Of Hope And Resilience In Pediatric Obesity Intervention Outcomes, Brigitte Dawn Beale

Browse all Theses and Dissertations

Childhood obesity is a major health concern in the United States (McClanahan, Huff, & Omar, 2009). In recent years, the prevalence of pediatric obesity has stabilized. However, a substantial decrease in obesity rates has not yet occurred, nor has the gap of health disparity been closed amongst ethnic groups experiencing obesity. African-American and Hispanic youth continue to experience obesity at substantially higher rates than other ethnic groups (Robert Wood Johnson Foundation, 2012). The purpose of this study was to examine correlations between Positive Psychology constructs and pediatric obesity intervention outcomes. A single-participant research design was utilized to compare baseline outcomes …

Myeloid Cell-Specific Abca1 Deletion Does Not Worsen Insulin Resistance In Hf Dietinduced Or Genetically Obese Mouse Models, Xuewei Zhu, Soonkyu Chung, Xin Bi, Chia-Chi Chuang, Amanda L. Brown, Mingxia Liu, Jeongmin Seo, Helen Cuffe, Abraham K. Gebre, Elena Boudyguina, John S. Parks

Department of Nutrition and Health Sciences: Faculty Publications

Obesity-associated low-grade chronic inflammation plays an important role in the development of insulin resistance. The membrane lipid transporter ATP-binding cassette transporter A1 (ABCA1) promotes formation of nascent HDL particles. ABCA1 also dampens macrophage inflammation by reducing cellular membrane cholesterol and lipid raft content. We tested the hypothesis that myeloid-specific ABCA1 deletion may exacerbate insulin resistance by increasing the obesity-associated chronic low-grade inflammation. Myeloid cell-specific ABCA1 knockout (MSKO) and wild-type (WT) mice developed obesity, insulin resistance, mild hypercholesterolemia, and hepatic steatosis to a similar extent with a 45% high-fat (HF) diet feeding or after crossing into the ob/ob background. Resident peritoneal …

Making Room For A Restorative Response To Conflict: Challenging The Retributive Paradigm In American Journalism, Cynthia Duggan Mwenja

All ETDs from UAB

Reactions to current events from across the political spectrum highlight a journalistic retributive narrative framework that is ubiquitous in the American media. News articles from the childhood obesity debate support claims that journalists on both left and right interpret this story - and by implication, all stories - through a retributive cultural lens. Burke's rhetorical analysis tool, dramatism, is used to examine the rhetoric on all sides of the issue and demonstrate the common retributive aspects of the narratives, regardless of the social or political orientations of the writers and their affiliations. The retributive narrative is connected to American justice …

Obesity, Prediabetes, And Perceived Stress In Municipal Workers, Louise Camilleri O'Keefe

All ETDs from UAB

Obesity and diabetes are major contributors to morbidity and mortality in the United States. According to the American Public Health Association and Partnership for Prevention, obesity is growing faster than any other public health problem in the United States. The prevalence of diabetes has also increased significantly with an estimated 79 million Americans aged 20 years or older suffering from prediabetes. Few studies have examined the influence of perceived stress on obesity and prediabetes among working adults. Investigations are needed to examine factors that can contribute to higher health care costs for both employees and employers. The aims of this …

Obesity Is An Independent Predictor Of Breastfeeding Initiation When Socioeconomic Status Is Controlled For, Annemarie Bennett, Daniel Mccartney, John Kearney

Articles

Breastfeeding initiation rates vary across Europe, with rates as low as 56%(1) in Ireland and rates in excess of 90%(2) in the Nordic countries. A host of factors, including demographic, social, psychological and physical factors, influence the initiation, intensity and duration of breastfeeding. The extent to which modifiable factors influence breastfeeding initiation should be ascertained in order to prioritise support services for breastfeeding. Obesity is a known modifiable factor which inhibits breastfeeding initiation. This study aimed to determine the extent to which obesity inhibits breastfeeding initiation while controlling for socioeconomic status and other confounding factors. The Infant Cohort dataset from …

Prevalence Of Overweight And Obesity In Classic Rett Syndrome., Kathrine Clova Grigsby

All ETDs from UAB

Introduction: Rett syndrome (RTT) is a genetic, neurodevelopmental disorder that displays high incidence of growth failure, variations in body composition, feeding/gastrointestinal complications, and undernutrition. The ongoing Rare Diseases Clinical Research Network (RDNCRN) Rett Syndrome Natural History Research Project has yielded observations regarding the less recognized occurrence of overnutrition in adult females with classic Rett syndrome. The purpose of this study was the determine the prevalence of overweight/obesity in children and young adults with classic Rett syndrome, the percent overweight and obese among adults with classic Rett syndrome, and to determine if the prevalence of overnutrition increases after the puberty years …

Socioeconomic Status, Social Relationships, And Higher Weight Status, Anthony David Campbell

All ETDs from UAB

This thesis serves two main research objectives. The first objective is to examine the extent to which higher weight status is patterned by indicators of socioeconomic status. The second objective is to explore the involvement of social relationships in the association between socioeconomic status and weight status. I use a theoretical framework incorporating aspects of fundamental cause theory and insights from the literature on social relationships and health. Data for this study were obtained from the 2003-2008 National Health and Nutrition Examination Survey (n = 3,957). The analytic sample focused on Black and White respondents over the age of 40. …

Apparent Change In Obesity-Mortality Associations: Methodological Issues In Survival Analyses With Censored Outcomes, Tapan Shirish Mehta

All ETDs from UAB

Analyses of the National Health and Nutrition Examination Survey (NHANES) have suggested that the mortality rate (MR) associated with obesity has decreased over calendar time. However, there has been conflicting evidence about the apparent change in the obesity-MR over calendar time. This dissertation investigates some of the empirical and methodological issues involved in assessing the longitudinal change in the obesity-mortality associations. In the first manuscript, Obesity and Mortality: Are the Risks Declining? Evidence from Multiple Prospective Studies in the U.S., a multiple longitudinal design is proposed and implemented to evaluate whether the obesity-mortality associations have declined over calendar time after …

Linking Obesity To Colorectal Cancer: Recent Insights Into Plausible Biological Mechanisms, Catherine Guffey

Theses and Dissertations

Obesity has emerged as a leading environmental risk factor for the development of CRC. However, the mechanisms underlying this relationship have not yet been fully explained. Recent literature has focused on 1) inflammatory processes, 2) adipokines, and 3) estrogen. Obesity-enhanced inflammation is largely orchestrated by increases in adipose tissue macrophages leading to the secretion of TNF-alpha, MCP-1, and IL-6, all of which are linked to CRC. Adiponectin is decreased with obesity and has been reported to be negatively associated with CRC, while leptin, which is increased, is positively associated with the disease. Estrogen has been shown to influence CRC, although …

Bmi At Diagnosis And Its Association With Markers Of Hiv Disease Progression And Cardiovascular Disease Risk., Kelly Deshon Johnson

Theses and Dissertations

Highly active antiretroviral treatment (HAART) has transformed the state of human immunodeficiency virus (HIV) from acute to chronic. As a result, the long-term effect of HAART has caused weight gain among HIV-infected individuals, leading to an increased prevalence of overweight and obesity. Increased Body Mass Index (BMI) has been associated with adverse health outcomes in non-HIV and HIV populations, yet among HIV-infected individuals, a higher BMI at diagnosis offers a slower progression from HIV to AIDS. Pre-HAART, studies reported that obese HIV-infected individuals have higher increases in CD4 count over time. However post-HAART, some report that overweight HIV-infected individuals with …

An Investigation Into The Influence Of Dietary Saturated Fat And Quercetin Supplementation On Adiposity, Macrophage Behavior, Inflammation, And Non-Alcoholic Fatty-Liver Disease, Reilly Enos

Theses and Dissertations

The overall objective of this dissertation was to examine the degree to which manipulation of the saturated fat content of a high-fat diet influenced obesity-related outcomes as well as to see if the naturally-occurring flavonoid, quercetin, could attenuate the resulting obesity and related metabolic and inflammatory side effects. Specifically, these studies examined 1) the influential role of saturated fat on macrophage function, inflammation, and other obesity-related comorbidities, including non-alcoholic fatty-liver disease, and 2) the potential benefits of quercetin supplementation. Overall, results from these studies suggest that adiposity, macrophage behavior, inflammation, insulin resistance, and non-alcoholic fatty-liver disease progression can be greatly …

The Relationship Between Socioeconomic Status And Body Mass Index On Vitamin D Levels In African American Women With And Without Diabetes Living In Areas With Abundant Sunshine, Shani Vann Davis

USF Tampa Graduate Theses and Dissertations

OBJECTIVE: To examine the relationships between socioeconomic status (SES), body mass index (BMI), and vitamin D levels in African American (AA) women living in areas with abundant sunshine; and to explore if diabetes moderates these relationships.

SIGNIFICANCE: More AA's live in poverty, and experience obesity, diabetes, and chronic disease compared to other groups. Eighty percent of AA women are overweight or obese, and rates of type 2 diabetes is highest in this group. Minority race, obesity, and diabetes increase risks for low vitamin D, and are associated with p

DESIGN AND METHOD: A cross-sectional descriptive research design was used to …

The Strong Black Woman, Depression, And Emotional Eating, Michelle Renee Offutt

USF Tampa Graduate Theses and Dissertations

Abstract

Eighty percent of all black women are overweight or obese which can lead to greatly increased morbidity and mortality, increasing healthcare costs and loss of healthy years of life. While multiple factors may contribute to obesity in black women, the cultural persona of the Strong Black Woman (SBW), an ideology that promotes unflagging toughness and denial of self-needs, may be the basis for behaviors that contribute to steady state obesity in this group. The purpose of this study was to investigate the relationships between the SBW persona, depression, and emotional eating.

Two predominately black churches in Florida were approached …